 |
|
EBI DbfetchID AAD20946; SV 1; linear; mRNA; STD; HUM; 7554 BP. XX PA AF113003.1 XX DE Homo sapiens (human) silencing mediator of retinoic acid and thyroid DE hormone receptor alpha XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; XX FH Key Location/Qualifiers FH FT source 1..7554 FT /organism="Homo sapiens" FT /chromosome="12" FT /map="12q24" FT /mol_type="mRNA" FT /tissue_type="pituitary" FT CDS AF113003.1:2..7555 FT /codon_start=1 FT /product="silencing mediator of retinoic acid and thyroid FT hormone receptor alpha" FT /function="transcriptional co-repressor" FT /note="hSMRT alpha; longer isoform than previously FT reported" FT /db_xref="GOA:Q9Y618" FT /db_xref="HGNC:7673" FT /db_xref="InterPro:IPR017884" FT /db_xref="PDB:1KKQ" FT /db_xref="UniProtKB/Swiss-Prot:Q9Y618" FT /func_characterised="similar sequence" FT /protein_id="AAD20946.1" FT /translation="MSGSTQLVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHH FT SRDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIE FT SKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELV FT PPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESK FT HRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLI FT LYFKRRNHARKQWKQKFCQRYDQLMEALEKKVERIENNPRRRAKESKVREYYEKQFPEI FT RKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPML FT YDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFL FT ERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQ FT EEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQG FT RRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWS FT AIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEA FT AFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPS FT PHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPRRTSRAPIEPTPASEATGAPTPPPAP FT PSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAE FT EGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAE FT GGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDA FT APTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAFAAEAQKLPGDPPC FT WTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPP FT LISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSG FT VKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITY FT RGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGM FT SVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPERHSPH FT HLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPSRDLTEAYKTQAL FT GPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTPLKYDT FT GASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLKSRPGTASSSGG FT SIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTMREPTPRLQEGSLSSSKA FT SQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIP FT RGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHH FT NTATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMD FT RLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSIL FT TSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQR FT PSVLHNTGMKGIITAVEPSKPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLM FT EPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHA FT TIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPE FT GVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLP FT ESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGA FT SCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPP FT EGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKK FT QEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAII FT RKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHTLTSPGGGGKAKV FT SGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPY FT NPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE" XX SQ Sequence 7554 BP; 1646 A; 2732 C; 2228 G; 948 T; 0 other; 661659246 CRC32; atgtcgggct ccacacagct tgtggcacag acgtggaggg ccactgagcc ccgctacccg 60 ccccacagcc tttcctaccc agtgcagatc gcccggacgc acacggacgt cgggctcctg 120 gagtaccagc accactcccg cgactatgcc tcccacctgt cgccgggctc catcatccag 180 ccccagcggc ggaggccctc cctgctgtct gagttccagc ccgggaatga acggtcccag 240 gagctccacc tgcggccaga gtcccactca tacctgcccg agctggggaa gtcagagatg 300 gagttcattg aaagcaagcg ccctcggcta gagctgctgc ctgaccccct gctgcgaccg 360 tcacccctgc tggccacggg ccagcctgcg ggatctgaag acctcaccaa ggaccgtagc 420 ctgacgggca agctggaacc ggtgtctccc cccagccccc cgcacactga ccctgagctg 480 gagctggtgc cgccacggct gtccaaggag gagctgatcc agaacatgga ccgcgtggac 540 cgagagatca ccatggtaga gcagcagatc tctaagctga agaagaagca gcaacagctg 600 gaggaggagg ctgccaagcc gcccgagcct gagaagcccg tgtcaccgcc gcccatcgag 660 tcgaagcacc gcagcctggt gcagatcatc tacgacgaga accggaagaa ggctgaagct 720 gcacatcgga ttctggaagg cctggggccc caggtggagc tgccgctgta caaccagccc 780 tccgacaccc ggcagtatca tgagaacatc aaaataaacc aggcgatgcg gaagaagcta 840 atcttgtact tcaagaggag gaatcacgct cggaaacaat ggaagcagaa gttctgccag 900 cgctatgacc agctcatgga ggccttggaa aaaaaggtgg agcgcatcga aaacaacccg 960 cgccggcggg ccaaggagag caaggtgcgc gagtactacg aaaagcagtt ccctgagatc 1020 cgcaagcagc gcgagctgca ggagcgcatg cagagcaggg tgggccagcg gggcagtggg 1080 ctgtccatgt cggccgcccg cagcgagcac gaggtgtcag agatcatcga tggcctctca 1140 gagcaggaga acctggagaa gcagatgcgc cagctggccg tgatcccgcc catgctgtac 1200 gacgctgacc agcagcgcat caagttcatc aacatgaacg ggcttatggc cgaccccatg 1260 aaggtgtaca aagaccgcca ggtcatgaac atgtggagtg agcaggagaa ggagaccttc 1320 cgggagaagt tcatgcagca tcccaagaac tttggcctga tcgcatcatt cctggagagg 1380 aagacagtgg ctgagtgcgt cctctattac tacctgacta agaagaatga gaactataag 1440 agcctggtga gacggagcta tcggcgccgc ggcaagagcc agcagcaaca acagcagcag 1500 cagcagcagc agcagcagca gcagcagcag cccatgcccc gcagcagcca ggaggagaaa 1560 gatgagaagg agaaggaaaa ggaggcggag aaggaggagg agaagccgga ggtggagaac 1620 gacaaggaag acctcctcaa ggagaagaca gacgacacct caggggagga caacgacgag 1680 aaggaggctg tggcctccaa aggccgcaaa actgccaaca gccagggaag acgcaaaggc 1740 cgcatcaccc gctcaatggc taatgaggcc aacagcgagg aggccatcac cccccagcag 1800 agcgccgagc tggcctccat ggagctgaat gagagttctc gctggacaga agaagaaatg 1860 gaaacagcca agaaaggtct cctggaacac ggccgcaact ggtcggccat cgcccggatg 1920 gtgggctcca agactgtgtc gcagtgtaag aacttctact tcaactacaa gaagaggcag 1980 aacctcgatg agatcttgca gcagcacaag ctgaagatgg agaaggagag gaacgcgcgg 2040 aggaagaaga agaaagcgcc ggcggcggcc agcgaggagg ctgcattccc gcccgtggtg 2100 gaggatgagg agatggaggc gtcgggcgtg agcggaaatg aggaggagat ggtggaggag 2160 gctgaagcct tacatgcctc tgggaatgag gtgcccagag gggaatgcag tggcccagcc 2220 actgtcaaca acagctcaga caccgagagc atcccctctc ctcacactga ggccgccaag 2280 gacacagggc agaatgggcc caagccccca gccaccctgg gcgccgacgg gccaccccca 2340 ggcccaccca ccccaccacg gaggacatcc cgggccccca ttgagcccac cccggcctct 2400 gaagccaccg gagcccctac gcccccacca gcacccccat cgccctctgc acctcctcct 2460 gtggtcccca aggaggagaa ggaggaggag accgcagcag cgcccccagt ggaggagggg 2520 gaggagcaga agccccccgc ggctgaggag ctggcagtgg acacagggaa ggccgaggag 2580 cccgtcaaga gcgagtgcac ggaggaagcc gaggaggggc cggccaaggg caaggacgcg 2640 gaggccgctg aggccacggc cgagggggcg ctcaaggcag agaagaagga gggcgggagc 2700 ggcagggcca ccactgccaa gagctcgggc gccccccagg acagcgactc cagtgctacc 2760 tgcagtgcag acgaggtgga tgaggccgag ggcggcgaca agaaccggct gctgtcccca 2820 aggcccagcc tcctcacccc gactggcgac ccccgggcca atgcctcacc ccagaagcca 2880 ctggacctga agcagctgaa gcagcgagcg gctgccatcc cccccatcca ggtcaccaaa 2940 gtccatgagc ccccccggga ggacgcagct cccaccaagc cagctccccc agccccaccg 3000 ccaccgcaaa acctgcagcc ggagagcgac gcccctcagc agcctggcag cagcccccgg 3060 ggcaagagca ggagcccggc accccccgcc gacaaggagg ccttcgcagc cgaggcccag 3120 aagctgcctg gggacccccc ttgctggact tccggcctgc ccttccccgt gcccccccgt 3180 gaggtgatca aggcctcccc gcatgccccg gacccctcag ccttctccta cgctccacct 3240 ggtcacccac tgcccctggg cctccatgac actgcccggc ccgtcctgcc gcgcccaccc 3300 accatctcca acccgcctcc cctcatctcc tctgccaagc accccagcgt cctcgagagg 3360 caaataggtg ccatctccca aggaatgtcg gtccagctcc acgtcccgta ctcagagcat 3420 gccaaggccc cggtgggccc tgtcaccatg gggctgcccc tgcccatgga ccccaaaaag 3480 ctggcaccct tcagcggagt gaagcaggag cagctgtccc cacggggcca ggctgggcca 3540 ccggagagcc tgggggtgcc cacagcccag gaggcgtccg tgctgagagg gacagctctg 3600 ggctcagttc cgggcggaag catcaccaaa ggcattccca gcacacgggt gccctcggac 3660 agcgccatca cataccgcgg ctccatcacc cacggcacgc cagctgacgt cctgtacaag 3720 ggcaccatca ccaggatcat cggcgaggac agcccgagtc gcttggaccg cggccgggag 3780 gacagcctgc ccaagggcca cgtcatctac gaaggcaaga agggccacgt cttgtcctat 3840 gagggtggca tgtctgtgac ccagtgctcc aaggaggacg gcagaagcag ctcaggaccc 3900 ccccatgaga cggccgcccc caagcgcacc tatgacatga tggagggccg cgtgggcaga 3960 gccatctcct cagccagcat cgaaggtctc atgggccgtg ccatcccgcc ggagcgacac 4020 agcccccacc acctcaaaga gcagcaccac atccgcgggt ccatcacaca agggatccct 4080 cggtcctacg tggaggcaca ggaggactac ctgcgtcggg aggccaagct cctaaagcgg 4140 gagggcacgc ctccgccccc accgccctca cgggacctga ccgaggccta caagacgcag 4200 gccctgggcc ccctgaagct gaagccggcc catgagggcc tggtggccac ggtgaaggag 4260 gcgggccgct ccatccatga gatcccgcgc gaggagctgc ggcacacgcc cgagctgccc 4320 ctggccccgc ggccgctcaa ggagggctcc atcacgcagg gcaccccgct caagtacgac 4380 accggcgcgt ccaccactgg ctccaaaaag cacgacgtac gctccctcat cggcagcccc 4440 ggccggacgt tcccacccgt gcacccgctg gatgtgatgg ccgacgcccg ggcactggaa 4500 cgtgcctgct acgaggagag cctgaagagc cggccaggga ccgccagcag ctcggggggc 4560 tccattgcgc gcggcgcccc ggtcattgtg cctgagctgg gtaagccgcg gcagagcccc 4620 ctgacctatg aggaccacgg ggcacccttt gccggccacc tcccacgagg ttcgcccgtg 4680 accatgcggg agcccacgcc gcgcctgcag gagggcagcc tttcgtccag caaggcatcc 4740 caggaccgaa agctgacgtc gacgcctcgt gagatcgcca agtccccgca cagcaccgtg 4800 cccgagcacc acccacaccc catctcgccc tatgagcacc tgcttcgggg cgtgagtggc 4860 gtggacctgt atcgcagcca catccccctg gccttcgacc ccacctccat accccgcggc 4920 atccctctgg acgcagccgc tgcctactac ctgccccgac acctggcccc caaccccacc 4980 tacccgcacc tgtacccacc ctacctcatc cgcggctacc ccgacacggc ggcgctggag 5040 aaccggcaga ccatcatcaa tgactacatc acctcgcagc agatgcacca caacacggcc 5100 accgccatgg cccagcgagc tgatatgctg aggggcctct cgccccgcga gtcctcgctg 5160 gcactcaact acgctgcggg tccccgaggc atcatcgacc tgtcccaagt gccacacctg 5220 cctgtgctcg tgcccccgac accaggcacc ccagccaccg ccatggaccg ccttgcctac 5280 ctccccaccg cgccccagcc cttcagcagc cgccacagca gctccccact ctccccagga 5340 ggtccaacac acttgacaaa accaaccacc acgtcctcgt ccgagcggga gcgagaccgg 5400 gatcgagagc gggaccggga tcgggagcgg gaaaagtcca tcctcacgtc caccacgacg 5460 gtggagcacg cacccatctg gagacctggt acagagcaga gcagcggcag cagcggcagc 5520 agcggcgggg gtgggggcag cagcagccgc cccgcctccc actcccatgc ccaccagcac 5580 tcgcccatct cccctcggac ccaggatgcc ctccagcaga gacccagtgt gcttcacaac 5640 acaggcatga agggtatcat caccgctgtg gagcccagca agcccacggt cctgaggtcc 5700 acctccacct cctcacccgt tcgcccagct gccacattcc cacctgccac ccactgccca 5760 ctgggcggca ccctcgatgg ggtctaccct accctcatgg agcccgtctt gctgcccaag 5820 gaggcccccc gggtcgcccg gccagagcgg ccccgagcag acaccggcca tgccttcctc 5880 gccaagcccc cagcccgctc cgggctggag cccgcctcct cccccagcaa gggctcggag 5940 ccccggcccc tagtgcctcc tgtctctggc cacgccacca tcgcccgcac ccctgcgaag 6000 aacctcgcac ctcaccacgc cagcccggac ccgccggcgc cacctgcctc ggcctcggac 6060 ccgcaccggg aaaagactca aagtaaaccc ttttccatcc aggaactgga actccgttct 6120 ctgggttacc acggcagcag ctacagcccc gaaggggtgg agcccgtcag ccctgtgagc 6180 tcacccagtc tgacccacga caaggggctc cccaagcacc tggaagagct cgacaagagc 6240 cacctggagg gggagctgcg gcccaagcag ccaggccccg tgaagcttgg cggggaggcc 6300 gcccacctcc cacacctgcg gccgctgcct gagagccagc cctcgtccag cccgctgctc 6360 cagaccgccc caggggtcaa aggtcaccag cgggtggtca ccctggccca gcacatcagt 6420 gaggtcatca cacaggacta cacccggcac cacccacagc agctcagcgc acccctgccc 6480 gcccccctct actccttccc tggggccagc tgccccgtcc tggacctccg ccgcccaccc 6540 agtgacctct acctcccgcc cccggaccat ggtgccccgg cccgtggctc cccccacagc 6600 gaagggggca agaggtctcc agagccaaac aagacgtcgg tcttgggtgg tggtgaggac 6660 ggtattgaac ctgtgtcccc accggagggc atgacggagc cagggcactc ccggagtgct 6720 gtgtacccgc tgctgtaccg ggatggggaa cagacggagc ccagcaggat gggctccaag 6780 tctccaggca acaccagcca gccgccagcc ttcttcagca agctgaccga gagcaactcc 6840 gccatggtca agtccaagaa gcaagagatc aacaagaagc tgaacaccca caaccggaat 6900 gagcctgaat acaatatcag ccagcctggg acggagatct tcaatatgcc cgccatcacc 6960 ggaacaggcc ttatgaccta tagaagccag gcggtgcagg aacatgccag caccaacatg 7020 gggctggagg ccataattag aaaggcactc atgggtaaat atgaccagtg ggaagagtcc 7080 ccgccgctca gcgccaatgc ttttaaccct ctgaatgcca gtgccagcct gcccgctgct 7140 atgcccataa ccgctgctga cggacggagt gaccacacac tcacctcgcc aggtggcggc 7200 gggaaggcca aggtctctgg cagacccagc agccgaaaag ccaagtcccc ggccccgggc 7260 ctggcatctg gggaccggcc accctctgtc tcctcagtgc actcggaggg agactgcaac 7320 cgccggacgc cgctcaccaa ccgcgtgtgg gaggacaggc cctcgtccgc aggttccacg 7380 ccattcccct acaaccccct gatcatgcgg ctgcaggcgg gtgtcatggc ttccccaccc 7440 ccaccgggcc tccccgcggg cagcgggccc ctcgctggcc cccaccacgc ctgggacgag 7500 gagcccaagc cactgctctg ctcgcagtac gagacactct ccgacagcga gtga 7554 // |
|