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EBI DbfetchID AAB69423; SV 1; linear; mRNA; STD; HUM; 3840 BP. XX PA AF016535.1 XX DE Homo sapiens (human) P-glycoprotein XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; XX FH Key Location/Qualifiers FH FT source 1..3840 FT /organism="Homo sapiens" FT /chromosome="7" FT /map="7q21.1" FT /mol_type="mRNA" FT /clone="8.1" FT /cell_line="MES-SA/DxP" FT /cell_type="drug-resistant uterine sarcoma" FT CDS AF016535.1:120..3959 FT /codon_start=1 FT /gene="mdr1" FT /product="P-glycoprotein" FT /function="transporter protein" FT /note="multidrug-resistance" FT /db_xref="GDB:120712" FT /db_xref="GOA:P08183" FT /db_xref="HGNC:40" FT /db_xref="HSSP:1MT0" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/Swiss-Prot:P08183" FT /func_characterised="similar sequence" FT /protein_id="AAB69423.1" FT /translation="MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNW FT LDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFF FT MNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWF FT DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAIS FT PVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNL FT EEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFSVLIG FT AFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFS FT YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIR FT TINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPH FT KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKAR FT KGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVE FT LENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPV FT SFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNL FT FSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGA FT LTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAG FT VVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNS FT LRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQ FT VSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPD FT IPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQW FT LRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYST FT KVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT FT CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ" XX SQ Sequence 3840 BP; 1130 A; 738 C; 957 G; 1015 T; 0 other; 104605372 CRC32; atggatcttg aaggggaccg caatggagga gcaaagaaga agaacttttt taaactgaac 60 aataaaagtg aaaaagataa gaaggaaaag aaaccaactg tcagtgtatt ttcaatgttt 120 cgctattcaa attggcttga caagttgtat atggtggtgg gaactttggc tgccatcatc 180 catggggctg gacttcctct catgatgctg gtgtttggag aaatgacaga tatctttgca 240 aatgcaggaa atttagaaga tctgatgtca aacatcacta atagaagtga tatcaatgat 300 acagggttct tcatgaatct ggaggaagac atgaccaggt atgcctatta ttacagtgga 360 attggtgctg gggtgctggt tgctgcttac attcaggttt cattttggtg cctggcagct 420 ggaagacaaa tacacaaaat tagaaaacag ttttttcatg ctataatgcg acaggagata 480 ggctggtttg atgtgcacga tgttggggag cttaacaccc gacttacaga tgatgtctcc 540 aagattaatg aaggaattgg tgacaaaatt ggaatgttct ttcagtcaat ggcaacattt 600 ttcactgggt ttatagtagg atttacacgt ggttggaagc taacccttgt gattttggcc 660 atcagtcctg ttcttggact gtcagctgct gtctgggcaa agatactatc ttcatttact 720 gataaagaac tcttagcgta tgcaaaagct ggagcagtag ctgaagaggt cttggcagca 780 attagaactg tgattgcatt tggaggacaa aagaaagaac ttgaaaggta caacaaaaat 840 ttagaagaag ctaaaagaat tgggataaag aaagctatta cagccaatat ttctataggt 900 gctgctttcc tgctgatcta tgcatcttat gctctggcct tctggtatgg gaccaccttg 960 gtcctctcag gggaatattc tattggacaa gtactcactg tattttctgt attaattggg 1020 gcttttagtg ttggacaggc atctccaagc attgaagcat ttgcaaatgc aagaggagca 1080 gcttatgaaa tcttcaagat aattgataat aagccaagta ttgacagcta ttcgaagagt 1140 gggcacaaac cagataatat taagggaaat ttggaattca gaaatgttca cttcagttac 1200 ccatctcgaa aagaagttaa gatcttgaag ggtctgaacc tgaaggtgca gagtgggcag 1260 acggtggccc tggttggaaa cagtggctgt gggaagagca caacagtcca gctgatgcag 1320 aggctctatg accccacaga ggggatggtc agtgttgatg gacaggatat taggaccata 1380 aatgtaaggt ttctacggga aatcattggt gtggtgagtc aggaacctgt attgtttgcc 1440 accacgatag ctgaaaacat tcgctatggc cgtgaaaatg tcaccatgga tgagattgag 1500 aaagctgtca aggaagccaa tgcctatgac tttatcatga aactgcctca taaatttgac 1560 accctggttg gagagagagg ggcccagttg agtggtgggc agaagcagag gatcgccatt 1620 gcacgtgccc tggttcgcaa ccccaagatc ctcctgctgg atgaggccac gtcagccttg 1680 gacacagaaa gcgaagcagt ggttcaggtg gctctggata aggccagaaa aggtcggacc 1740 accattgtga tagctcatcg tttgtctaca gttcgtaatg ctgacgtcat cgctggtttc 1800 gatgatggag tcattgtgga gaaaggaaat catgatgaac tcatgaaaga gaaaggcatt 1860 tacttcaaac ttgtcacaat gcagacagca ggaaatgaag ttgaattaga aaatgcagct 1920 gatgaatcca aaagtgaaat tgatgccttg gaaatgtctt caaatgattc aagatccagt 1980 ctaataagaa aaagatcaac tcgtaggagt gtccgtggat cacaagccca agacagaaag 2040 cttagtacca aagaggctct ggatgaaagt atacctccag tttccttttg gaggattatg 2100 aagctaaatt taactgaatg gccttatttt gttgttggtg tattttgtgc cattataaat 2160 ggaggcctgc aaccagcatt tgcaataata ttttcaaaga ttataggggt ttttacaaga 2220 attgatgatc ctgaaacaaa acgacagaat agtaacttgt tttcactatt gtttctagcc 2280 cttggaatta tttcttttat tacatttttc cttcagggtt tcacatttgg caaagctgga 2340 gagatcctca ccaagcggct ccgatacatg gttttccgat ccatgctcag acaggatgtg 2400 agttggtttg atgaccctaa aaacaccact ggagcattga ctaccaggct cgccaatgat 2460 gctgctcaag ttaaaggggc tataggttcc aggcttgctg taattaccca gaatatagca 2520 aatcttggga caggaataat tatatccttc atctatggtt ggcaactaac actgttactc 2580 ttagcaattg tacccatcat tgcaatagca ggagttgttg aaatgaaaat gttgtctgga 2640 caagcactga aagataagaa agaactagaa ggtgctggga agatcgctac tgaagcaata 2700 gaaaacttcc gaaccgttgt ttctttgact caggagcaga agtttgaaca tatgtatgct 2760 cagagtttgc aggtaccata cagaaactct ttgaggaaag cacacatctt tggaattaca 2820 ttttccttca cccaggcaat gatgtatttt tcctatgctg gatgtttccg gtttggagcc 2880 tacttggtgg cacataaact catgagcttt gaggatgttc tgttagtatt ttcagctgtt 2940 gtctttggtg ccatggccgt ggggcaagtc agttcatttg ctcctgacta tgccaaagcc 3000 aaaatatcag cagcccacat catcatgatc attgaaaaaa cccctttgat tgacagctac 3060 agcacggaag gcctaatgcc gaacacattg gaaggaaatg tcacatttgg tgaagttgta 3120 ttcaactatc ccacccgacc ggacatccca gtgcttcagg gactgagcct ggaggtgaag 3180 aagggccaga cgctggctct ggtgggcagc agtggctgtg ggaagagcac agtggtccag 3240 ctcctggagc ggttctacga ccccttggca gggaaagtgc tgcttgatgg caaagaaata 3300 aagcgactga atgttcagtg gctccgagca cacctgggca tcgtgtccca ggagcccatc 3360 ctgtttgact gcagcattgc tgagaacatt gcctatggag acaacagccg ggtggtgtca 3420 caggaagaga ttgtgagggc agcaaaggag gccaacatac atgccttcat cgagtcactg 3480 cctaataaat atagcactaa agtaggagac aaaggaactc agctctctgg tggccagaaa 3540 caacgcattg ccatagctcg tgcccttgtt agacagcctc atattttgct tttggatgaa 3600 gccacgtcag ctctggatac agaaagtgaa aaggttgtcc aagaagccct ggacaaagcc 3660 agagaaggcc gcacctgcat tgtgattgct caccgcctgt ccaccatcca gaatgcagac 3720 ttaatagtgg tgtttcagaa tggcagagtc aaggagcatg gcacgcatca gcagctgctg 3780 gcacagaaag gcatctattt ttcaatggtc agtgtccagg ctggaacaaa gcgccagtga 3840 // |
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