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EBI Dbfetch
ID BX842576; SV 1; linear; genomic DNA; STD; PRO; 348264 BP.
XX
AC BX842576; AL021006; AL021184; AL022000; Z73419; Z73902; Z75555; Z77137;
AC Z77164; Z77826; Z79701; Z80108; Z81011; Z83862; Z95844;
XX
DT 21-NOV-2003 (Rel. 77, Created)
DT 23-OCT-2008 (Rel. 97, Last updated, Version 5)
XX
DE Mycobacterium tuberculosis H37Rv complete genome; segment 5/13
XX
KW complete genome.
XX
OS Mycobacterium tuberculosis H37Rv
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
XX
RN [1]
RX DOI; 10.1038/31159.
RX PUBMED; 9634230.
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Sqares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence";
RL Nature 393(6685):537-544(1998).
XX
RN [2]
RX PUBMED; 12368430.
RA Camus J.C., Pryor M.J., Medigue C., Cole S.T.;
RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv";
RL Microbiology (Reading, Engl.) 148(Pt 10):2967-2973(2002).
XX
RN [3]
RP 1-348264
RA Parkhill J.;
RT ;
RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases.
RL Submitted on behalf of the Mycobacterium tuberculosis sequencing and
RL mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton,
RL Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut
RL Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
RL parkhill@sanger.ac.uk
XX
DR EMBL-CON; AL123456.
DR RFAM; RF01118; PK-G12rRNA.
DR SILVA-LSU; BX842576.
DR SILVA-SSU; BX842576.
XX
CC Notes:
CC Details of M. tuberculosis sequencing at the Sanger Centre
CC are available on the World Wide Web.
CC (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/)
XX
FH Key Location/Qualifiers
FH
FT source 1..348264
FT /organism="Mycobacterium tuberculosis H37Rv"
FT /strain="H37Rv"
FT /mol_type="genomic DNA"
FT /db_xref="taxon:83332"
FT CDS 170..1159
FT /transl_table=11
FT /gene="mdh"
FT /locus_tag="Rv1240"
FT /product="PROBABLE MALATE DEHYDROGENASE MDH"
FT /function="INVOLVED IN THE CONVERSION OF MALATE TO
FT OXALOACETATE [CATALYTIC ACTIVITY: (S)-malate + NAD+ =
FT oxaloacetate + NADH]."
FT /EC_number="1.1.1.37"
FT /note="Rv1240, (MTV006.12), len: 329 aa. Probable mdh,
FT Malate dehydrogenase (EC 1.1.1.37). Most similar to
FT P50917|MDH_MYCLE MALATE DEHYDROGENASE from Mycobacterium
FT leprae (329 aa), FASTA scores: opt: 1887, E(): 0, (89.1%
FT identity in 329 aa overlap). Contains PS00068 Malate
FT dehydrogenase active site signature. BELONGS TO THE LDH
FT FAMILY. MDH SUBFAMILY. TBparse score is 0.867."
FT /db_xref="GOA:P0A5J6"
FT /db_xref="InterPro:IPR001236"
FT /db_xref="InterPro:IPR001252"
FT /db_xref="InterPro:IPR001557"
FT /db_xref="InterPro:IPR010945"
FT /db_xref="InterPro:IPR015955"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5J6"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA15896.1"
FT /translation="MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIE
FT PALQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSDLLE
FT ANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNR
FT AISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLFHAEVAGKNAAEVVNDQAWIEDEFIP
FT TVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLI
FT SSFPVTTKGGNWTIVSGLEIDEFSRGRIDKSTAELADERSAVTELGLI"
FT misc_feature 635..673
FT /note="PS00068 Malate dehydrogenase active site signature"
FT CDS 1235..1495
FT /transl_table=11
FT /locus_tag="Rv1241"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1241, (MTV006.13), len: 86 aa. Conserved
FT hypothetical protein, member of family of 16 hypothetical
FT Mycobacterium tuberculosis proteins including:
FT Rv2871|Q10799|YS71_MYCTU HYPOTHETICAL 13.2 kDa PROTEIN CY2
FT (124 aa), FASTA scores: opt: 172, E(): 9.5e-06, (37.2%
FT identity in 86 aa overlap); Rv2132, Rv3321c, etc. TBparse
FT score is 0.875."
FT /db_xref="UniProtKB/TrEMBL:O50456"
FT /protein_id="CAA15897.1"
FT /translation="MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQ
FT EQYRLEPHESAVRSGLDLAGFNKLADELEDEALLDATRRAR"
FT CDS 1492..1923
FT /transl_table=11
FT /locus_tag="Rv1242"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1242, (MTV006.14), len: 143 aa. Conserved
FT hypothetical protein, member of family of 14 hypothetical
FT Mycobacterium tuberculosis proteins including:
FT Rv2872|Q10800|YS72_MYCTU (147 aa), FASTA scores: opt: 226,
FT E(): 2.7e-09, (32.1% identity in 137 aa overlap); Rv0749,
FT Rv0277c, Rv2530c, etc. TBparse score is 0.893."
FT /db_xref="InterPro:IPR006226"
FT /db_xref="UniProtKB/TrEMBL:O50457"
FT /protein_id="CAA15898.1"
FT /translation="MIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALF
FT GFLRIATSARVLAAPLPTADAIAYVREWLSQPNVDLLTAGPRHLDIALGLLDKLGTASH
FT LTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE"
FT CDS complement(1946..3634)
FT /transl_table=11
FT /gene="PE_PGRS23"
FT /locus_tag="Rv1243c"
FT /product="PE-PGRS FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1243c, (MTV006.15c), len: 562 aa. Member of the
FT Mycobacterium tuberculosis PE family, PGRS subfamily of
FT gly-rich proteins (see Brennan & Delogu 2002). TBparse
FT score is 0.875."
FT /db_xref="InterPro:IPR000084"
FT /db_xref="UniProtKB/TrEMBL:Q79FQ7"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55374.1"
FT /translation="MEYLIAAQDVLVAAAADLEGIGSALAAANRAAEAPTTGLLAAGAD
FT EVSAAIASLFSGNAQAYQALSAQAAAFHQQFVRALSSAAGSYAAAEAANASPMQAVLDV
FT VNGPTQLLLGRPLIGDGANGGPGQNGGDGGLLYGNGGNGGSSSTPGQPGGRGGAAGLIG
FT NGGAGGAGGPGANGGAGGNGGWLYGNGGLGGNGGAATQIGGNGGNGGHGGNAGLWGNGG
FT AGGAGAAGAAGANGQNPVSHQVTHATDGADGTTGPDGNGTDAGSGSNAVNPGVGGGAGG
FT IGGDGTNLGQTDVSGGAGGDGGDGANFASGGAGGNGGAAQSGFGDAVGGNGGAGGNGGA
FT GGGGGLGGAGGSANVANAGNSIGGNGGAGGNGGIGAPGGAGGAGGNANQDNPPGGNSTG
FT GNGGAGGDGGVGASADVGGAGGFGGSGGRGGLLLGTGGAGGDGGVGGDGGIGAQGGSGG
FT NGGNGGIGADGMANQDGDGGDGGNGGDGGAGGAGGVGGNGGTGGAGGLFGQSGSPGSGA
FT AGGLGGAGGNGGAGGGGGTGFNPGAPGDPGTQGATGANGQHGLNG"
FT CDS 3814..4674
FT /transl_table=11
FT /gene="lpqZ"
FT /locus_tag="Rv1244"
FT /product="PROBABLE LIPOPROTEIN LPQZ"
FT /function="UNKNOWN"
FT /note="Rv1244, (MTV006.16), len: 286 aa. Probable
FT lipoprotein lpqZ, equivalent toU15180|MLU1518042 protein
FT u1756x from Mycobacterium leprae (228 aa), FASTA scores:
FT opt: 1039, E(): 0, (72.5% identity in 229 aa overlap).
FT Similar to Mycobacterium tuberculosis hypothetical protein
FT Rv3759c. Contains PS00013 Prokaryotic membrane lipoprotein
FT lipid attachment site. TBparse score is 0.878."
FT /db_xref="GOA:O50459"
FT /db_xref="InterPro:IPR007210"
FT /db_xref="UniProtKB/TrEMBL:O50459"
FT /protein_id="CAA15900.1"
FT /translation="MRITRILALLLAVLLAVSGVAGCSADTGDRHPELVVGSTPDSEAM
FT LLAAIYVAALRSYGFAAHAETAADPVAKLDSGAFTVVPAFTGQMLQTLQPDASVRSDAQ
FT VYRAIVSALPEGIAAGDYTTAAEDKPALVVTQSTAKAWGGGDLSELPSHCRGLLVGRVA
FT GAHTPAAVGPCRLPAPREFRNDATMFAALRAGQLVAAWTTTADPDIPADLIMLTDGKPA
FT LIRAENIVPLYRRNALTERQLLAVNEVAGVLDTTALIGMRRQVAAGADPAAVAAGWLAE
FT HPLGR"
FT misc_feature 3850..3882
FT /note="PS00013 Prokaryotic membrane lipoprotein lipid
FT attachment site"
FT CDS complement(4755..5585)
FT /transl_table=11
FT /locus_tag="Rv1245c"
FT /product="PROBABLE SHORT-CHAIN TYPE
FT DEHYDROGENASE/REDUCTASE"
FT /function="UNKNOWN; SUPPOSED INVOLVED IN CELLULAR
FT METABOLISM."
FT /EC_number="1.-.-.-"
FT /note="Rv1245c, (MTV006.17c), len: 276 aa. Probable
FT short-chain dehydrogenase/reductase (EC 1.-.-.-),
FT equivalent to NP_301801.1|NC_002677 short chain alcohol
FT dehydrogenase from Mycobacterium leprae (277 aa). Also
FT highly similar to various dehydrogenases and
FT oxidoreductases e.g. NP_250228.1|NC_002516 probable
FT short-chain dehydrogenase from Pseudomonas aeruginosa (295
FT aa); NP_421969.1|NC_002696 short chain dehydrogenase family
FT protein from Caulobacter crescentus (278 aa); etc. Also
FT highly similar to others from Mycobacterium tuberculosis
FT e.g. Rv3085|MTV013.06 PROBABLE SHORT-CHAIN TYPE
FT DEHYDROGENASE/REDUCTASE (276 aa), FASTA scores: opt: 368,
FT E(): 1.2e-16, (35.3% identity in 224 aa overlap);
FT Rv3057c|MTCY22D7.24 PUTATIVE SHORT CHAIN ALCOHOL
FT DEHYDROGENASE/REDUCTASE (287 aa), FASTA scores: opt: 471,
FT E(): 1.3e-21, (32.4% identity in 281 aa overlap); etc.
FT Contains PS00061 Short-chain dehydrogenases/reductases
FT family signature. BELONGS TO THE SHORT-CHAIN
FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is
FT 0.871."
FT /db_xref="GOA:O50460"
FT /db_xref="HSSP:1A27"
FT /db_xref="HSSP:1FDW"
FT /db_xref="InterPro:IPR002198"
FT /db_xref="InterPro:IPR002347"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="UniProtKB/TrEMBL:O50460"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA15901.1"
FT /translation="MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTDGLAD
FT TEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTGDIEVSQF
FT KDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLFSAPGQAAYNSAKFAVR
FT GFTEALRQEMALAGHPVKVTTVHPGGVKTAIARNATAAEGLDQAELAETFDKRVAHLSP
FT QRAAQIILTGVAKNKARVLVGVDAKVLDLVVRLTGSGYQRIFPIITGRLIPRPR"
FT misc_feature complement(5076..5162)
FT /note="PS00061 Short-chain alcohol dehydrogenase family
FT signature"
FT CDS complement(5642..5935)
FT /transl_table=11
FT /locus_tag="Rv1246c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1246c, (MTV006.18c), len: 97 aa. Conserved
FT hypothetical protein, highly similar to Rv2866|MTV003.12
FT hypothetical Mycobacterium tuberculosis protein (87 aa),
FT FASTA scores: opt: 290, E(): 3.9e-24, (54.1% identity in 85
FT aa overlap)."
FT /db_xref="InterPro:IPR007712"
FT /db_xref="UniProtKB/TrEMBL:O50461"
FT /protein_id="CAA15902.1"
FT /translation="MSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRL
FT GKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEIIHIARRSASYRMNPCRPR"
FT CDS complement(5932..6201)
FT /transl_table=11
FT /locus_tag="Rv1247c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1247c, (MTV006.19c), len: 89 aa. Conserved
FT hypothetical protein, some similarity to hypothetical
FT proteins including Mycobacterium tuberculosis proteins
FT Rv2865|MTV003.11 (93 aa), FASTA scores: opt: 249, E():
FT 5.4e-13, (44.2% identity in 86 aa overlap);
FT Rv0268|Z86089|P95225 (169 aa) opt: 125, E(): 0.0089, (41.8%
FT identity in 55 aa overlap); etc. and Escherichia coli
FT AE000293|ECAE0002933 (92 aa), FASTA scores: opt: 127, E():
FT 0.0038, (29.3% identity in 82 aa overlap). TBparse score is
FT 0.905."
FT /db_xref="InterPro:IPR003756"
FT /db_xref="InterPro:IPR006442"
FT /db_xref="UniProtKB/TrEMBL:O50462"
FT /protein_id="CAA15903.1"
FT /translation="MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDL
FT ASIEETLEVLRTPGASEAIREGLADVAAGRFVSNDEIRNRYTAR"
FT CDS complement(6314..9958)
FT /transl_table=11
FT /gene="sucA"
FT /locus_tag="Rv1248c"
FT /product="PROBABLE 2-OXOGLUTARATE DEHYDROGENASE SUCA
FT (Alpha-ketoglutarate dehydrogenase)"
FT /function="THE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX
FT CATALYZES THE OVERALL CONVERSION OF 2-OXOGLUTARATE TO
FT SUCCINYL-CoA & CO(2). IT CONTAINS MULTIPLE COPIES OF 3
FT ENZYMATIC COMPONENTS:2-OXOGLUTARATE DEHYDROGENASE (E1),
FT DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE (E2) AND LIPOAMIDE
FT DEHYDROGENASE (E3) [CATALYTIC ACTIVITY: 2-oxoglutarate +
FT lipoamide = S-succinyldihydrolipoamide + CO2]"
FT /EC_number="1.2.4.2"
FT /note="Rv1248c, (MTV006.20c), len: 1214 aa. Probable sucA,
FT 2-oxoglutarate dehydrogenase (EC 1.2.4.2), highly similar
FT to several but closest to D84102 Corynebacterium glutamicum
FT (1257 aa), FASTA scores: opt: 4418, E(): 0, (59.4% identity
FT in 1223 aa overlap). TBparse score is 0.882."
FT /db_xref="GOA:O50463"
FT /db_xref="InterPro:IPR001017"
FT /db_xref="InterPro:IPR001078"
FT /db_xref="InterPro:IPR005475"
FT /db_xref="InterPro:IPR011603"
FT /db_xref="UniProtKB/Swiss-Prot:O50463"
FT /protein_id="CAA15904.1"
FT /translation="MYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAE
FT RAAAAAPQAPPKPADTAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSAS
FT LEVPTATSVRAVPAKLLIDNRIVINNQLKRTRGGKISFTHLLGYALVQAVKKFPNMNRH
FT YTEVDGKPTAVTPAHTNLGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRR
FT ARDGKLTTEDFAGVTISLTNPGTIGTVHSVPRLMPGQGAIIGVGAMEYPAEFQGASEER
FT IAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHELLLSDGFWDEVFRELSIPYLPVRW
FT STDNPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWD
FT LDRVFKVDGFAGAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVK
FT PTVAQQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDE
FT VVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFG
FT DNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAF
FT AGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIF
FT HVNGDDPEACVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDT
FT KRGARKSYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHGVQPSESVESDQ
FT MIPAGLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGKIDWAFGELL
FT ALGSLVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKF
FT LVYDSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQL
FT SNVVLLLPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQ
FT RPLIVFTPKSMLRHKAAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLY
FT YELAARKAKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPR
FT FGLELPELLPDKLAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFG"
FT CDS complement(10151..10939)
FT /transl_table=11
FT /locus_tag="Rv1249c"
FT /product="POSSIBLE MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1249c, (MTV006.21c), len: 262 aa. Possible
FT membrane protein. Start uncertain. TBparse score is 0.899."
FT /db_xref="UniProtKB/TrEMBL:O50464"
FT /protein_id="CAA15905.1"
FT /translation="MSARRIRSWKRFDNRSANAAEPDPQLAGTGGRPKVSTRALAQVIE
FT RSSRIQGPAAQAYVARLRRAHPGASPAKIVAKLEKRFLSVVTASGAAVGAAATLPGIGT
FT LAAWFAAAGEVVVFLEATALFVLALASVHAIPLDHRERRRALVLAVLVGDNTTAVADLL
FT GPGRTSGGWVSETMASLPLPAISSLNSRMLKYVVKRFALKRGALMFGKLVPMGIGAIIG
FT AIGNRLVGKKLVRNARSAFGTPPARWPVTLHVLPTVRDAS"
FT CDS 11136..12875
FT /transl_table=11
FT /locus_tag="Rv1250"
FT /product="PROBABLE DRUG-TRANSPORT INTEGRAL MEMBRANE
FT PROTEIN"
FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF DRUG
FT ACROSS THE MEMBRANE (EXPORT): DRUG RESISTANCE BY AN EXPORT
FT MECHANISM (CONFERES RESISTANCE TO TOXIC COMPOUNDS BY
FT REMOVING THEM FOR THE CELLS). RESPONSIBLE FOR THE
FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE."
FT /note="Rv1250, (MTV006.22), len: 579 aa. Probable
FT drug-transport integral membrane protein, member of major
FT facilitator superfamily (MFS), highly similar to several
FT including P39886|TCMA_STRGA TETRACENOMYCIN C RESISTANCE
FT PROTEIN from Streptomyces glaucescens (538 aa), FASTA
FT scores: opt: 847, E(): 0, (32.9% identity in 517 aa
FT overlap); etc. Also similar to MTCY20B11.14c|Rv3239C from
FT Mycobacterium tuberculosis (1048 aa), FASTA scores: opt:
FT 629, E(): 6.7e-13, (31.9% identity in 423 aa overlap).
FT TBparse score is 0.921."
FT /db_xref="GOA:O50465"
FT /db_xref="InterPro:IPR004638"
FT /db_xref="InterPro:IPR011701"
FT /db_xref="InterPro:IPR016196"
FT /db_xref="UniProtKB/TrEMBL:O50465"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA15906.1"
FT /translation="MTTAIRRAAGSSYFRNPWPALWAMMVGFFMIMLDSTVVAIANPTI
FT MAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLGDRFGPKNLYLIGLGVFTVASLGCGLS
FT SGAGMLIAARVVQGVGAGLLTPQTLSTITRIFPAHRRGVALGAWGTVASVASLVGPLAG
FT GALVDSMGWEWIFFVNVPVGVIGLILAAYLIPALPHHPHRFDWFGVGLSGAGMFLIVFG
FT LQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNAREPLIPLEVFNDRNFSLSNLRIAI
FT IAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGGVLAPFVGMIIDRSHPLCVLG
FT FGFSVLAIAMTWLLCEMAPGTPIWRLVLPFIALGVAGAFVWSPLTVTATRNLRPHLAGA
FT SSGVFNAVRQLGAVLGSASMAAFMTSRIAAEMPGGVDALTGPAGQDATVLQLPEFVREP
FT FAAAMSQSMLLPAFVALFGIVAALFLVDFTGAAVAKEPLPESDGDADDDDYVEYILRRE
FT PEEDCDTQPLRASRPAAAAASRSGAGGPLAVSWSTSAQGMPPGPPGRRAWQADTESTAP
FT SAL"
FT CDS complement(12778..16197)
FT /transl_table=11
FT /locus_tag="Rv1251c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1251c, (MTV006.23c), len: 1139 aa. Conserved
FT hypothetical protein, showing some similarity in C-terminal
FT region with other proteins from eukaryotes and bacteria
FT e.g. NP_142121.1 hypothetical protein from Pyrococcus
FT horikoshii (1188 aa); and some similarity to GTP-binding
FT proteins e.g. P23249|MV10_MOUSE PUTATIVE GTP-BINDING
FT PROTEIN (1004 aa), FASTA scores: opt: 228, E(): 1.7e-06,
FT (27.7% identity in 560 aa overlap). Contains PS00017
FT ATP/GTP-binding site motif A (P-loop). TBparse score is
FT 0.906."
FT /db_xref="GOA:O50466"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR019993"
FT /db_xref="UniProtKB/TrEMBL:O50466"
FT /protein_id="CAA15907.1"
FT /translation="MFVTGDSIVYSASDLAAAARCQYALLREFDAKLGRGPAVAVDDEL
FT MARAAVLGSAHEGRRLDQLRHEFGDAVAIIGRPAYTPAGLAAAADATRRAIANHAPVVY
FT QAAMFDGRFVGFADFLIRDGHRYRVADTKLARSPTVTALLQLAAYADALVHSGVPVAAD
FT AELELGDGTIVRYRVGELIPVYRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQC
FT TERLRASDDLLLVGGMRVRQRDKLLEAGITTIAELADHTAPVPGLTTNALGKLTAQAKL
FT QIRQRDTGAPQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQWGLEYLFGVLEA
FT GRAGVFRPLWAHDRTAERQALTDFLAIVARRRRRHPNMHIYHYAPYEKTALLRLVGRYG
FT IGEDDVDDLLRNGVLVDLYPLVRKSIRVGTDSFSLKALEPLYLGTQPRSGDVTTAADSI
FT NSYARYCELRAAGRIDEAATVLKEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQP
FT VPDADPIDDGDSLASVLSKFTGDAAAGERTPEQTAVALLAAARGYHRREDKPFWWAHFD
FT RLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTGELARGDLNGNVFALY
FT EPPAPPGMTDNPDRRAAGPAAVVETDDPTVPTEVVIVERTGSDGNTFQQLPFALAPGPP
FT VPTTALRESIESTAAAVASGSPQLPSTALMDVLLRRPPRTRSGAALPRSSDPVTDIAAA
FT ALDLDSSYLAVHGPPGTGKTYTAARVIAELVTEHAWRIGVVAQSHATVENLLEGVISAG
FT LDPGQVAKKPHDHTAGRWQSIDGSQYTEFIRDTAGCVIGGTAWDFANGNRVPKASLDLL
FT VIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPEPVDTSALSWLVDGQHTL
FT PDERGYFLDRSYRMHPAVCAAVSALSYEGRLCSHTERTAVRRLDGYPPGVHTRGVHHKG
FT NSIESPEEAEAILAELRQLLGSPWTDEHGTRPLAASDVLVLAPYNAQVALVRRRLASAG
FT LGGADGVRVGTVDKFQGGQAPVVFISMTASSADDVPRGISFLLNRNRLNVAVSRAQYAA
FT VIVRSELLTQYLPATPDGLVDLGAFLGLTSTS"
FT misc_feature complement(13879..13902)
FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT CDS complement(16253..16861)
FT /transl_table=11
FT /gene="lprE"
FT /locus_tag="Rv1252c"
FT /product="PROBABLE LIPOPROTEIN LPRE"
FT /function="UNKNOWN"
FT /note="Rv1252c, (MTCY50.30), len: 202 aa. Probable
FT lipoprotein lprE, some similarity to Mycobacterium
FT tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa), FASTA
FT scores: E(): 7e-05, (29.5% identity in 200 aa overlap).
FT Contains possible N-terminal signal sequence and
FT appropriately positioned prokaryotic lipoprotein lipid
FT attachment site (PS00013)."
FT /db_xref="GOA:P65312"
FT /db_xref="UniProtKB/Swiss-Prot:P65312"
FT /protein_id="CAB00900.1"
FT /translation="MPGVWSPPCPTTPRVGVVAALVAATLTGCGSGDSTVAKTPEATPS
FT LSTAHPAPPSSEPSPPSATAAPPSNHSAAPVDPCAVNLASPTIAKVVSELPRDPRSEQP
FT WNPEPLAGNYNECAQLSAVVIKANTNAGNPTTRAVMFHLGKYIPQGVPDTYGFTGIDTS
FT QCTGDTVALTYASGIGLNNVVKFRWNGGGVELIGNTTGG"
FT CDS 16927..18618
FT /transl_table=11
FT /gene="deaD"
FT /locus_tag="Rv1253"
FT /product="PROBABLE COLD-SHOCK DEAD-BOX PROTEIN A HOMOLOG
FT DEAD (ATP-dependent RNA helicase deaD homolog)"
FT /function="HAS A HELIX-DESTABILIZING ACTIVITY"
FT /note="Rv1253, (MTCY50.29c), len: 563 aa. Probable Dead,
FT Cold-shock DEAD-box protein A homolog, similar to many e.g.
FT DEAD_ECOLI|P23304 Escherichia coli (646 aa), FASTA scores:
FT opt: 1490, E(): 0, (46.7% identity in 578 aa overlap);
FT similar to Mycobacterium tuberculosis Rv3211. Contains
FT PS00017 ATP/GTP-binding site motif A, PS00039 DEAD-box
FT subfamily ATP-dependent helicases signature. BELONGS TO THE
FT DEAD BOX FAMILY HELICASE."
FT /db_xref="GOA:Q11039"
FT /db_xref="InterPro:IPR000629"
FT /db_xref="InterPro:IPR001650"
FT /db_xref="InterPro:IPR005580"
FT /db_xref="InterPro:IPR011545"
FT /db_xref="InterPro:IPR014001"
FT /db_xref="InterPro:IPR014014"
FT /db_xref="InterPro:IPR014021"
FT /db_xref="UniProtKB/Swiss-Prot:Q11039"
FT /protein_id="CAB00899.1"
FT /translation="MAFPEYSPAASAATFADLQIHPRVLRAIGDVGYESPTAIQAATIP
FT ALMAGSDVVGLAQTGTGKTAAFAIPMLSKIDITSKVPQALVLVPTRELALQVAEAFGRY
FT GAYLSQLNVLPIYGGSSYAVQLAGLRRGAQVVVGTPGRMIDHLERATLDLSRVDFLVLD
FT EADEMLTMGFADDVERILSETPEYKQVALFSATMPPAIRKLSAKYLHDPFEVTCKAKTA
FT VAENISQSYIQVARKMDALTRVLEVEPFEAMIVFVRTKQATEEIAEKLRARGFSAAAIS
FT GDVPQAQRERTITALRDGDIDILVATDVAARGLDVERISHVLNYDIPHDTESYVHRIGR
FT TGRAGRSGAALIFVSPRELHLLKAIEKATRQTLTEAQLPTVEDVNTQRVAKFADSITNA
FT LGGPGIELFRRLVEEYEREHDVPMADIAAALAVQCRGGEAFLMAPDPPLSRRNRDQRRD
FT RPQRPKRRPDLTTYRVAVGKRHKIGPGAIVGAIANEGGLHRSDFGQIRIGPDFSLVELP
FT AKLPRATLKKLAQTRISGVLIDLRPYRPPDAARRHNGGKPRRKHVG"
FT misc_feature 17095..17118
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature 17407..17433
FT /note="PS00039 DEAD-box subfamily ATP-dependent helicases
FT signature"
FT CDS 18615..19766
FT /transl_table=11
FT /locus_tag="Rv1254"
FT /product="PROBABLE ACYLTRANSFERASE"
FT /function="CATALYZES THE ACYLATION OF THE MYCAMINOSE SUGAR
FT DURING MIDECAMYCIN BIOSYNTHESIS"
FT /EC_number="2.3.1.-"
FT /note="Rv1254, (MTCY50.28c), len: 383 aa. Probable
FT Acyltransferase (EC 2.3.1.-), similar to G927228
FT midecamycin 4-0-propionyl transferase (fragment) (388 aa),
FT FASTA scores, opt: 305, E(): 5.6e-14, (28.4% identity in
FT 377 aa overlap). Also similar to other Mycobacterium
FT tuberculosis acyltransferases e.g. Rv0111, Rv0228, etc.
FT Contains PS00881 Protein splicing signature."
FT /db_xref="GOA:Q11064"
FT /db_xref="InterPro:IPR002656"
FT /db_xref="UniProtKB/TrEMBL:Q11064"
FT /protein_id="CAB00898.1"
FT /translation="MTLPKERAAQGGLERIAHVDRVASLTGIRAVAALLVVGTHAAYTT
FT GKYTHGYWGLMSSRMEIGVPIFFVLSGFLLFRPWVKSAATGGPPPSLSRYAWHRVRRIM
FT PAYTVTVLLAYLVYHFRTAGPNPGHTWVGLFRNLTLTQIYTDGYLGAFLHQGLTQMWSL
FT AVEVAFYLALPALAYLLLVLVCRRRWQPRLLLATMAGLTMISPAWLILVHNTHWMPDGA
FT RLWLPTYLAWFVGGMMLAVLAAMGVRCYAFVAIPLAVICYFIVSTPIAGAPTTSPTALA
FT EALVKTAFYAVIAVLAVAPLALGDQGWYAQLLASRPMVFLGEISYEIFLIHLVTMEIAM
FT VDVLGYRVYTSSMVNLCLVTLVLTIPLAWLLHRFTRVQGDRPS"
FT misc_feature 19242..19259
FT /note="PS00881 Protein splicing signature"
FT CDS complement(19735..20343)
FT /transl_table=11
FT /locus_tag="Rv1255c"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT /note="Rv1255c, (MTCY50.27), len: 202 aa. Possible
FT regulatory protein, similar to others e.g.
FT ACRR_ECOLI|P34000 potential acrab operon repressor from E.
FT coli (215 aa), FASTA scores: opt: 128, E(): 0.25, (42.1%
FT identity in 57 aa overlap). Helix turn helix motif present
FT at aa 36-57 (+5.48 SD)."
FT /db_xref="GOA:Q11063"
FT /db_xref="InterPro:IPR001647"
FT /db_xref="InterPro:IPR009057"
FT /db_xref="InterPro:IPR012287"
FT /db_xref="UniProtKB/Swiss-Prot:Q11063"
FT /protein_id="CAB00897.1"
FT /translation="MAGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAAG
FT CSRATLYRYFDSREALRTAYVHRETRRLGREIMVKIADVVEPAERLLVSITTTLRMVRD
FT NPALAAWFTTTRPPIGGEMAGRSEVIAALAAAFLNSLGPDDPTTVERRARWVVRMLTSL
FT LMFPGRDEADERAMIAEFVVPIVTPASAAARKAGHPGPE"
FT CDS complement(20343..21560)
FT /transl_table=11
FT /gene="cyp130"
FT /locus_tag="Rv1256c"
FT /product="PROBA BLE CYTOCHROME P450 130 CYP130"
FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE
FT MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY
FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND
FT XENOBIOTICS."
FT /EC_number="1.14.-.-"
FT /note="Rv1256c, (MT1295, MTCY50.26), len: 405 aa. Probable
FT cyp130, cytochrome P450 (EC 1.14.-.-), similar to other
FT cytochromes P-450 e.g. S51594 cytochrome P450 mycG from
FT Micromonospora griseorubida (397 aa); T36526 probable
FT cytochrome P450 hydroxylase from Streptomyces coelicolor
FT (411 aa); CPXK_SACER|P33271|107B1 CYTOCHROME P450 from
FT Saccharopolyspora erythraea (405 aa), FASTA scores: opt:
FT 639, E(): 2.7e-33, (33.2% identity in 391 aa overlap); etc.
FT Also similar to others from Mycobacterium tuberculosis e.g.
FT Rv0766c|MTCY369.11c CYTOCHROME P450 (402 aa); etc. Contains
FT PS00086 Cytochrome P450 cysteine heme-iron ligand
FT signature. BELONGS TO THE CYTOCHROME P450 FAMILY."
FT /db_xref="GOA:Q11062"
FT /db_xref="InterPro:IPR001128"
FT /db_xref="InterPro:IPR002397"
FT /db_xref="InterPro:IPR017972"
FT /db_xref="PDB:2UUQ"
FT /db_xref="PDB:2UVN"
FT /db_xref="PDB:2WGY"
FT /db_xref="PDB:2WH8"
FT /db_xref="PDB:2WHF"
FT /db_xref="UniProtKB/Swiss-Prot:Q11062"
FT /protein_id="CAB00896.1"
FT /translation="MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEYD
FT YYVLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLV
FT SRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPEEDW
FT TQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVG
FT ADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPDAVE
FT ELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRC
FT PRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSV
FT PFRVTS"
FT misc_feature complement(20493..20522)
FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand
FT signature"
FT CDS complement(21674..23041)
FT /transl_table=11
FT /locus_tag="Rv1257c"
FT /product="PROBABLE OXIDOREDUCTASE"
FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT METABOLISM"
FT /EC_number="1.-.-.-"
FT /note="Rv1257c, (MTCY50.25), len: 455 aa. Probable
FT oxidoreductase (EC 1.-.-.-), similar to e.g.
FT GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa),
FT FASTA scores: E(): 0, (38.9% identity in 458 aa overlap).
FT Similar to Mycobacterium tuberculosis oxidoreductases e.g.
FT Rv3107c"
FT /db_xref="GOA:Q11061"
FT /db_xref="InterPro:IPR004113"
FT /db_xref="InterPro:IPR006094"
FT /db_xref="InterPro:IPR016164"
FT /db_xref="InterPro:IPR016166"
FT /db_xref="InterPro:IPR016167"
FT /db_xref="UniProtKB/TrEMBL:Q11061"
FT /protein_id="CAB00895.1"
FT /translation="MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAII
FT RPRRTEEVQTVLRWASANQVPVVTRGAGSGLSGGATALDGGIVLSTEKMRDITVDPVTR
FT TAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTGDYV
FT LGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPAQNASSIV
FT VASFGSVQAAVDAVLGVTGRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLVAGSDE
FT RGRAATEDAAVMAAVFAENGAIDVFSTDDPDEGEAFIAARRFAIPAVESKGALLLEDVG
FT VPLPALGELVTGIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLERAHLAYGEI
FT MDLAVGLGGTITGEHGVGRLKRPWLAGYLGPDVLALNQRIKQALDPQGILNPGSAI"
FT CDS complement(23038..24297)
FT /transl_table=11
FT /locus_tag="Rv1258c"
FT /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT
FT PROTEIN"
FT /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF
FT UNDETERMINATED SUBSTRATE (POSSIBLY MACROLIDE) ACROSS THE
FT MEMBRANE (EXPORT). RESPONSIBLE FOR THE TRANSLOCATION OF THE
FT UNDETERMINATED SUBSTRATE ACROSS THE MEMBRANE."
FT /note="Rv1258c, MTCY50.24, len: 419 aa. Probable conserved
FT integral membrane transport (efflux) protein, possibly
FT member of major facilitator superfamily (MFS), highly
FT similar to O32859|TAP PROTEIN multidrug-resistance efflux
FT pump from Mycobacterium fortuitum (409 aa), FASTA scores:
FT E(): 0, (68.4% identity in 408 aa overlap). Contains
FT PS00216 Sugar transport proteins signature 1."
FT /db_xref="GOA:P64783"
FT /db_xref="InterPro:IPR011701"
FT /db_xref="InterPro:IPR016196"
FT /db_xref="UniProtKB/Swiss-Prot:P64783"
FT /protein_id="CAB00894.1"
FT /translation="MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQAS
FT IVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVL
FT VLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGL
FT MIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNL
FT RVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVL
FT AIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRA
FT AQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPA
FT LRELDLAPQADIDRPVGSAQ"
FT misc_feature complement(24064..24114)
FT /note="PS00216 Sugar transport proteins signature 1"
FT CDS 24296..25195
FT /transl_table=11
FT /locus_tag="Rv1259"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1259, (MTCY50.23c), len: 299 aa. Conserved
FT hypothetical protein. Similar to AL109732|SC7H2.04
FT hypothetical protein from Streptomyces coelicolor (237 aa),
FT FASTA scores: opt: 870, E(): 0, (57.1% identity in 231 aa
FT overlap)."
FT /db_xref="InterPro:IPR005122"
FT /db_xref="UniProtKB/Swiss-Prot:P64785"
FT /protein_id="CAB00912.1"
FT /translation="MNIAAESSAKPVWGPPNFCAAAARMQDVRVLMHPKTGRAFRSPVE
FT PGSGWPGDPATPQTPVAADAAQVSALAGGAGSICELNALISVCRACPRLVSWREEVAVV
FT KRRAFADQPYWGRPVPGWGSKRPRLLILGLAPAAHGANRTGRMFTGDRSGDQLYAALHR
FT AGLVNSPVSVDAADGLRANRIRITAPVRCAPPGNSPTPAERLTCSPWLNAEWRLVSDHI
FT RAIVALGGFAWQVALRLAGASGTPKPRFGHGVVTELGAGVRLLGCYHPSQQNMFTGRLT
FT PTMLDDIFREAKKLAGIE"
FT CDS 25197..26315
FT /transl_table=11
FT /locus_tag="Rv1260"
FT /product="PROBABLE OXIDOREDUCTASE"
FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT METABOLISM."
FT /EC_number="1.-.-.-"
FT /note="Rv1260, (MTCY50.22c), len: 372 aa. Probable
FT oxidoreductase (EC 1.-.-.-), highly similar to
FT E1245747|AL021411 putative oxidoreductase SC7H1.18 from
FT Streptomyces coelicolor (397 aa), FASTA scores: E():
FT 1.4e-29, (45.9% identity in 355 aa overlap); also some
FT similarity to G912582 FAD binding protein homologue from
FT Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245,
FT E(): 2e-09, (27.5% identity in 251 aa overlap);
FT PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537
FT aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity
FT in 360 aa overlap); TETX_BACFR|Q01911 tetracycline
FT resistance protein (388 aa), FASTA scores: opt: 183, E():
FT 3e-05, (22.8% identity in 373 aa overlap). Also similar to
FT Mycobacterium tuberculosis hypothetical proteins Rv0575c
FT and Rv1751."
FT /db_xref="GOA:Q11058"
FT /db_xref="InterPro:IPR002938"
FT /db_xref="InterPro:IPR003042"
FT /db_xref="UniProtKB/Swiss-Prot:Q11058"
FT /protein_id="CAB00893.1"
FT /translation="MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV
FT RGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTESTPTGGPVNSPDIELLR
FT DDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFERAAAREFDLVIGADGLHSNVR
FT RLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARNNTEARAALA
FT FMDTELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWSR
FT GRVALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAGDDYQLGFANYHAEFHGFVER
FT NQWLVSDNIPGGAPIPQEEFERIVHSITIKDY"
FT CDS complement(26441..26890)
FT /transl_table=11
FT /locus_tag="Rv1261c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1261c, (MTCY50.21), len: 149 aa. Conserved
FT hypothetical protein, similar to Mycobacterium tuberculosis
FT hypothetical proteins e.g. Rv1558|MTCY48.07c (39.2%
FT identity in 125 aa overlap); Rv3547 and Rv3178."
FT /db_xref="InterPro:IPR004378"
FT /db_xref="UniProtKB/Swiss-Prot:P64787"
FT /protein_id="CAB00892.1"
FT /translation="MDISRWLERHVGVQLLRLHDAIYRGTNGRIGHRIPGAPPSLLLHT
FT TGAKTSQPRTTSLTYARDGDAYLIVASKGGDPRSPGWYHNLKANPDVEINVGPKRFGVT
FT AKPVQPHDPDYARLWQIVNENNANRYTNYQSRTSRPIPVVVLTRR"
FT CDS complement(26895..27329)
FT /transl_table=11
FT /locus_tag="Rv1262c"
FT /product="HYPOTHETICAL HIT-LIKE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1262c, (MTCY50.20), len: 144 aa. Hypothetical
FT HIT-like protein, similar to Q04344|HIT_YEAST hit1 protein
FT (orf u) (144 aa), FASTA scores: opt: 306, E(): 3e-14, (35.9
FT % identity in 142 aa overlap); also similar to
FT YHIT_MYCGE|P47378 hypothetical 15.6 kDa protein (141 aa),
FT FASTA scores: opt: 250, E(): 1.6e-10, (35.5% identity in
FT 107 aa overlap); and YHIT_MYCLE|P49774 hypothetical 17.0
FT kDa protein hit-like (155 aa), FASTA scores: opt: 196, E():
FT 7e-07, (30.6% identity in 144 aa overlap). Similar to other
FT proteins from Mycobacterium tuberculosis e.g. Rv2613c,
FT Rv0759c. Contains PS00892 HIT family signature. BELONGS TO
FT THE HIT FAMILY."
FT /db_xref="GOA:Q11066"
FT /db_xref="InterPro:IPR001310"
FT /db_xref="InterPro:IPR011146"
FT /db_xref="InterPro:IPR011151"
FT /db_xref="InterPro:IPR019808"
FT /db_xref="UniProtKB/Swiss-Prot:Q11066"
FT /protein_id="CAB00913.1"
FT /translation="MPCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRH
FT TVDLTDTPPEALADMVAIGQRIARAARATKLADATHIAINDGRAAFQTVFHVHLHVLPP
FT RNGDKLSVAKGMMLRRDPDREATGRILREALAQQDAAAQD"
FT misc_feature complement(27030..27077)
FT /note="PS00892 HIT family signature"
FT CDS 27388..28776
FT /transl_table=11
FT /gene="amiB2"
FT /locus_tag="Rv1263"
FT /product="PROBABLE AMIDASE AMIB2 (AMINOHYDROLASE)"
FT /function="INVOLVED IN CELLULAR METABOLISM, ACTIVE ON 2- to
FT 6- CARBON ALIPHATIC AMIDES AND ON MANY AROMATIC AMIDES
FT [CATALYTIC ACTIVITY : A MONOCARBOXYLIC ACID AMIDE + H(2)O =
FT A MONOCARBOXYLATE + NH(3)]."
FT /EC_number="3.5.1.4"
FT /note="Rv1263, (MTCY50.19c), len: 462 aa. Probable amiB2,
FT amidase (EC 3.5.1.4). Similar to G1001278 hypothetical 54.3
FT kDa protein (506 aa), FASTA scores: opt: 767, E(): 7.6e-40,
FT (32.8% identity in 461 aa overlap), also similar to G580673
FT rhodococcus enantiose lective amidase gene (462 aa), FASTA
FT scores, opt: 668, E(): 7.4e-34, (33.5% identity in 484 aa
FT overlap) also to NYLA_PSES8|P13398
FT 6-aminohexanoate-cyclic-dimer hydrolase (492 aa), FASTA
FT scores opt: 543, E(): 3.1e-26, (33.5% identity in 493 aa
FT overlap). Also similar to MTCY274.19c (33.5% identity in
FT 427 aa overlap). Similar to other putative amidases in M.
FT tuberculosis; Rv2363, Rv2888c, etc. Contains PS00017
FT ATP/GTP-binding site motif A. BELONGS TO THE AMIDASE
FT FAMILY."
FT /db_xref="GOA:P63492"
FT /db_xref="InterPro:IPR000120"
FT /db_xref="InterPro:IPR020556"
FT /db_xref="UniProtKB/Swiss-Prot:P63492"
FT /protein_id="CAB00891.1"
FT /translation="MDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERLDSHLRA
FT YRVVQFDRARAEAEAAQQRLDAGERLPLLGVPIAIKDDVDIAGEVTTYGSAGHGPAATS
FT DAEVVRRLRAAGAVIIGKTNVPELMIMPFTESLAFGATRNPWCLNRTPGGSSGGSAAAV
FT AAGLAPVALGSDGGGSIRIPCTWCGLFGLKPQRDRISLEPHDGAWQGLSVNGPIARSVM
FT DAALLLDATTTVPGPEGEFVAAAARQPGRLRIALSTRVPTPLPVRCGKQELAAVHQAGA
FT LLRDLGHDVVVRDPDYPASTYANYLPRFFRGISDDADAQAHPDRLEARTRAIARLGSFF
FT SDRRMAALRAAEVVLSSRIQSIFDDVDVVVTPGAATGPSRIGAYQRRGAVSTLLLVVQR
FT VPYFQVWNLTGQPAAVVPWDFDGDGLPMSVQLVGRPYDEATLLALAAQIESARPWAHRR
FT PSVS"
FT misc_feature 27733..27756
FT /note="PS00017 ATP/GTP-binding site motif A"
FT CDS 28851..30044
FT /transl_table=11
FT /locus_tag="Rv1264"
FT /product="ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE)
FT (ADENYLATE CYCLASE)"
FT /function="POSSIBLY INVOLVED IN cAMP SYNTHESIS [CATALYTIC
FT ACTIVITY: ATP = 3',5'-CYCLIC AMP + DIPHOSPHATE]."
FT /EC_number="4.6.1.1"
FT /note="Rv1264, (MTCY50.18c), len: 397 aa. Adenylate cyclase
FT (EC 4.6.1.1) (function proven experimentally: see Linder et
FT al., 2002), showing some similarity to other adenylate
FT cyclases e.g. CYAA_BRELI|P27580 (403 aa), FASTA scores,
FT opt: 270, E(): 1.3e-10, (29.3% identity in 317 aa overlap);
FT etc. Similar to other putative cyclases in M. tuberculosis
FT e.g. Rv2212, Rv1647. The C terminus seems to code for a
FT catalytic domain belonging to a subfamily of adenylyl
FT cyclase isozymes (mostly found in Gram-positive bacteria).
FT The N terminus seems to be a potential novel regulator of
FT adenylyl cyclase activity (autoinhibitory domain). BELONGS
FT TO THE ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY."
FT /db_xref="GOA:Q11055"
FT /db_xref="InterPro:IPR001054"
FT /db_xref="PDB:1Y10"
FT /db_xref="PDB:1Y11"
FT /db_xref="PDB:2EV1"
FT /db_xref="PDB:2EV2"
FT /db_xref="PDB:2EV3"
FT /db_xref="PDB:2EV4"
FT /db_xref="UniProtKB/Swiss-Prot:Q11055"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB00890.1"
FT /translation="MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEI
FT RATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHM
FT RADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDI
FT AKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFAD
FT LVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTV
FT LKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVR
FT EALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP"
FT CDS 30217..30897
FT /transl_table=11
FT /locus_tag="Rv1265"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN. SEEMS TO BE EXPRESSED DURING MACROPHAGE
FT INFECTION."
FT /note="Rv1265, (MTCY50.17c), len: 226 aa. Hypothetical
FT unknown protein (see citation below)."
FT /db_xref="UniProtKB/Swiss-Prot:P64789"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB00889.1"
FT /translation="MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMHG
FT RRYGRPGGWQQAQQPDASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLESPE
FT EESAARASGRVSRFRDETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVPVMT
FT RLKQPERQVLDTLVDAGVARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLRAQGP
FT DLPA"
FT CDS complement(30917..32797)
FT /transl_table=11
FT /gene="pknH"
FT /locus_tag="Rv1266c"
FT /product="PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN
FT KINASE H PKNH (PROTEIN KINASE H) (STPK H)"
FT /function="INVOLVED IN SIGNAL TRANSDUCTION (VIA
FT PHOSPHORYLATION). THOUGHT TO BE INVOLVED IN ARABINAN
FT METABOLISM, PHOSPHORYLATING PERHAPS EMBR|Rv1267c [CATALYTIC
FT ACTIVITY: ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN]."
FT /EC_number="2.7.1.-"
FT /note="Rv1266c, (MTCY50.16), len: 626 aa. Probable pknH,
FT transmembrane serine/threonine-protein kinase (EC 2.7.1.-)
FT (see citation below), similar to many e.g.
FT PKN1_MYXXA|P33973 pkn1 (693 aa), FASTA scores: opt: 611,
FT E(): 1.4e- 14, (29.7% identity in 492 aa overlap); etc.
FT Contains PS00107 Protein kinases ATP-binding region
FT signature; PS00108 Serine/Threonine protein kinases
FT active-site signature. Contains Hank's kinase subdomain.
FT BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.
FT Experimental studies show evidence of
FT auto-phosphorylation."
FT /db_xref="GOA:Q11053"
FT /db_xref="InterPro:IPR000719"
FT /db_xref="InterPro:IPR008271"
FT /db_xref="InterPro:IPR011009"
FT /db_xref="InterPro:IPR017441"
FT /db_xref="InterPro:IPR017442"
FT /db_xref="UniProtKB/Swiss-Prot:Q11053"
FT /protein_id="CAB00914.1"
FT /translation="MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVK
FT LMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSV
FT LKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRDDFAYLVDFGIASA
FT TTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYALACVLHECLTGAPPYRADSAGT
FT LVSSHLMGPIPQPSAIRPGIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQ
FT DHAADILRRSQESTLPAPPKPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPA
FT QPGPAGQRPGPTGQPSWAPNSGPMPASGPTPTPQYYQGGGWGAPPSGGPSPWAQTPRKT
FT NPWPLVAGAAAVVLVLVLGAIGIWIAIRPKPVQPPQPVAEERLSALLLNSSEVNAVMGS
FT SSMQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHW
FT VNQAVVAFPTADKARAFVQTSADKWKNCAGKTVTVTNKAKTYRWTFADVKGSPPTITVI
FT DTQEGAEGWECQRAMSVANNVVVDVNACGYRITNQAGQIAAKIVDKVNKE"
FT misc_feature complement(32357..32395)
FT /note="PS00108 Serine/Threonine protein kinases active-site
FT signature"
FT misc_feature complement(32663..32734)
FT /note="PS00107 Protein kinases ATP-binding region
FT signature"
FT CDS complement(33138..34304)
FT /transl_table=11
FT /gene="embR"
FT /locus_tag="Rv1267c"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN EMBR"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM. THOUGHT
FT TO REGULATE THE BIOSYNTHESIS OF THE MYCOBACTERIAL CELL WALL
FT ARABINAN AND RESISTANCE TO ETHAMBUTOL (Emb;
FT dextro-2,2'-(ethylenediimino)-di-1-butanol), REGULATING
FT EMBA|Rv3794 AND EMBB|Rv3795."
FT /note="Rv1267c, (MT1305, MTCY50.15), len: 388 aa. Probable
FT embR, regulatory protein (see citation below), similar to
FT many e.g. AFSR_STRCO|P25941 regulatory protein AfsR from
FT Streptomyces coelicolor (993 aa), FASTA scores: opt: 489,
FT E(): 1e-25, (33.5% identity in 361 aa overlap); etc.
FT BELONGS TO THE AFSR/DNRI/REDD FAMILY OF REGULATORS."
FT /db_xref="GOA:P66799"
FT /db_xref="InterPro:IPR000253"
FT /db_xref="InterPro:IPR001867"
FT /db_xref="InterPro:IPR005158"
FT /db_xref="InterPro:IPR008984"
FT /db_xref="InterPro:IPR011991"
FT /db_xref="InterPro:IPR016032"
FT /db_xref="PDB:2FEZ"
FT /db_xref="PDB:2FF4"
FT /db_xref="UniProtKB/Swiss-Prot:P66799"
FT /protein_id="CAB00888.1"
FT /translation="MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVIN
FT RNRPVGVDALITALWEEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLS
FT IPDNTCDLGRFVAEKTAGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFA
FT TALVEDKVLAHTAKAEAEIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQS
FT DALGAYRRVKTTLADDLGIDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRT
FT MASGQQAVAYLHDIASGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYV
FT INDLRSSNGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT"
FT CDS complement(34615..35313)
FT /transl_table=11
FT /locus_tag="Rv1268c"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1268c, (MTCY50.14), len: 232 aa. Hypothetical
FT unknown protein, probably secreted protein : contains
FT possible signal peptide sequence (score 7.9 at residue
FT 28)."
FT /db_xref="GOA:P64791"
FT /db_xref="InterPro:IPR000169"
FT /db_xref="UniProtKB/Swiss-Prot:P64791"
FT /protein_id="CAB00911.1"
FT /translation="MTTSKIATAFKTATFALAAGAVALGLASPADAAAGTMYGDPAAAA
FT KYWRQQTYDDCVLMSAADVIGQVTGREPSERAIIKVAQSTPSVVHPGSIYTKPADAEHP
FT NSGMGTSVADIPTLLAHYGVDAVITDEDHATATGVATGMAALEQYLGSGHAVIVSINAE
FT MIWGQPVEETDSAGNPRSDHAVVVTGVDTENGIVHLNDSGTPTGRDEQIPMETFVEAWA
FT TSHDFMAVTT"
FT CDS complement(35536..35910)
FT /transl_table=11
FT /locus_tag="Rv1269c"
FT /product="CONSERVED PROBABLE SECRETED PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1269c, (MTCY50.13), len: 124 aa. Conserved
FT probable exported protein with putative N-terminal signal
FT sequence. Similar to Mycobacterium tuberculosis protein
FT Rv1813c|Y0DU_MYCTU|Q50620 hypothetical protein cy1a11.30
FT (137 aa), FASTA scores: E(): 9e-21, (41.6% identity in 137
FT aa overlap)."
FT /db_xref="InterPro:IPR017909"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5E1"
FT /protein_id="CAB00910.1"
FT /translation="MTTMITLRRRFAVAVAGVATAAATTVTLAPAPANAADVYGAIAYS
FT GNGSWGRSWDYPTRAAAEATAVKSCGYSDCKVLTSFTACGAVAANDRAYQGGVGPTLAA
FT AMKDALTKLGGGYIDTWACN"
FT CDS complement(35971..36705)
FT /transl_table=11
FT /gene="lprA"
FT /locus_tag="Rv1270c"
FT /product="POSSIBLE LIPOPROTEIN LPRA"
FT /function="UNKNOWN"
FT /note="Rv1270c, (MTCY50.12), len: 244 aa. Possible lprA,
FT lipoprotein. Similar to O32852|AJ000500 lipoprotein from
FT Mycobacterium bovis (236 aa), fasta scores: E(): 5.2e-23,
FT (35.1% identity in 245 aa overlap). Similar to M.
FT tuberculosis lipoproteins: Rv1368, Rv1411c, Rv2945c.
FT Contains probable N-terminal signal sequence."
FT /db_xref="GOA:Q11049"
FT /db_xref="InterPro:IPR009830"
FT /db_xref="UniProtKB/Swiss-Prot:Q11049"
FT /protein_id="CAB00915.1"
FT /translation="MKHPPCSVVAAATAILAVVLAIGGCSTEGDAGKASDTAATASNGD
FT AAMLLKQATDAMRKVTGMHVRLAVTGDVPNLRVTKLEGDISNTPQTVATGSATLLVGNK
FT SEDAKFVYVDGHLYSDLGQPGTYTDFGNGASIYNVSVLLDPNKGLANLLANLKDASVAG
FT SQQADGVATTKITGNSSADDIATLAGSRLTSEDVKTVPTTVWIASDGSSHLVQIQIAPT
FT KDTSVTLTMSDWGKQVTATKPV"
FT CDS complement(36918..37259)
FT /transl_table=11
FT /locus_tag="Rv1271c"
FT /product="CONSERVED HYPOTHETICAL SECRETED PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1271c, (MTCY50.11), len: 113 aa. Conserved
FT hypothetical exported protein with potential N-terminal
FT signal sequence. Similar to Mycobacterium tuberculosis
FT hypothetical proteins Rv1804c, Rv1810, Rv0622, etc."
FT /db_xref="InterPro:IPR007969"
FT /db_xref="UniProtKB/Swiss-Prot:P64793"
FT /protein_id="CAB00909.1"
FT /translation="MLSPLSPRIIAAFTTAVGAAAIGLAVATAGTAGANTKDEAFIAQM
FT ESIGVTFSSPQVATQQAQLVCKKLASGETGTEIAEEVLSQTNLTTKQAAYFVVDATKAY
FT CPQYASQLT"
FT CDS complement(37367..39262)
FT /transl_table=11
FT /locus_tag="Rv1272c"
FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE
FT ATP-BINDING PROTEIN ABC TRANSPORTER"
FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE
FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO
FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE
FT SUBSTRATE ACROSS THE MEMBRANE."
FT /note="Rv1272c, (MTCY50.10), len: 631 aa. Probable
FT drugs-transport transmembrane ATP-binding protein ABC
FT transporter (see citation below), similar to e.g.
FT Y015_MYCGE|P47261 hypothetical ABC transporter mg015m from
FT Mycoplasma genitalium (589 aa), FASTA scores: opt: 1054,
FT E(): 0, (34.3% identity in 522 aa overlap); etc. Contains
FT PS00017 ATP/GTP-binding site motif A (P-loop); and PS00211
FT ABC transporters family signature. BELONGS TO THE
FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS),
FT MSBA SUBFAMILY."
FT /db_xref="GOA:P63397"
FT /db_xref="InterPro:IPR001140"
FT /db_xref="InterPro:IPR003439"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR011527"
FT /db_xref="InterPro:IPR017871"
FT /db_xref="InterPro:IPR017940"
FT /db_xref="UniProtKB/Swiss-Prot:P63397"
FT /protein_id="CAB00908.1"
FT /translation="MTAPPGARPRAASPPPNMRSRDFWGSAARLVKRLAPQRRLSIAVI
FT TLGIAGTTIGVIVPRILGHATDLLFNGVIGRGLPGGITKAQAVASARARGDNTFADLLS
FT GMNVVPGQGVDFAAVERTLALALALYLAAALMIWAQARLLNLTVQKTMVRLRTDVEDKV
FT HRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTISQLVTSILTMVAVLAMMVSISGLL
FT ALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRLNAHLEETYSGFTVVKTFGHQAAA
FT RERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGYVAVAVAGGLQVATGQITLGSIQ
FT AFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLDEPEESPEPEPELPNLTGRVEF
FT EHVNFAYLPGTPVIRDLSLVAEPGSTVAIVGPTGAGKTTLVNLLMRFYEIGSGRILIDG
FT VDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAYGRPEATTDEIVEAARAAHVDRFVN
FT TLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQLLILDEATSSVDTRTELLIQRAM
FT RELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERGNHAELLARRGVYYQMTRA"
FT misc_feature complement(37619..37663)
FT /note="PS00211 ABC transporters family signature"
FT misc_feature complement(37952..37975)
FT /note="PS00017 ATP/GTP-binding site motif A"
FT CDS complement(39259..41007)
FT /transl_table=11
FT /locus_tag="Rv1273c"
FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE
FT ATP-BINDING PROTEIN ABC TRANSPORTER"
FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE
FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO
FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE
FT SUBSTRATE ACROSS THE MEMBRANE."
FT /note="Rv1273c, (MTCY50.09), len: 582 aa. Probable
FT drugs-transport transmembrane ATP-binding protein ABC
FT transporter (see citation below), similar to e.g.
FT YWJA_BACSU|P45861 hypothetical abc transporter from B.
FT subtilis (575 aa), FASTA scores: opt: 810, E(): 0, (27.0%
FT identity in 578 aa overlap); etc. Contains PS00136 Serine
FT proteases, subtilase family, aspartic acid active site; 2 x
FT PS00211 ABC transporters family signature; and PS00017
FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE
FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS),
FT MSBA SUBFAMILY."
FT /db_xref="GOA:P0A4W4"
FT /db_xref="InterPro:IPR001140"
FT /db_xref="InterPro:IPR003439"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR011527"
FT /db_xref="InterPro:IPR017871"
FT /db_xref="InterPro:IPR017940"
FT /db_xref="UniProtKB/Swiss-Prot:P0A4W4"
FT /protein_id="CAB00907.1"
FT /translation="MLLALLRQHIRPYRRLVAMLMMLQLVSTLASLYLPTVNAAIVDDG
FT VAKGDTATIVRLGAVMLGVTGLQVLCAIGAVYLGSRTGAGFGRDLRSAMFEHIITFSER
FT ETARFGAPTLLTRSTNDVRQILFLVQMTATVLVTAPIMCVGGIIMAIHQEAALTWLLLV
FT SVPILAVANYWIISHMLPLFRRMQSLIDGINRVMRDQLSGVRVVRAFTREGYERDKFAQ
FT ANTALSNAALSAGNWQALMLPVTTLTINASSVALIWFGGLRIDSGQMQVGSLIAFLSYF
FT AQILMAVLMATMTLAVLPRASVCAERITEVLSTPAALGNPDNPKFPTDGVTGVVRLAGA
FT TFTYPGADCPVLQDISLTARPGTTTAIVGSTGSGKSTLVSLICRLYDVTAGAVLVDGID
FT VREYHTERLWSAIGLVPQRSYLFSGTVADNLRYGGGPDQVVTEQEMWEALRVAAADGFV
FT QTDGLQTRVAQGGVNFSGGQRQRLAIARAVIRRPAIYVFDDAFSALDVHTDAKVHASLR
FT QVSGDATIIVVTQRISNAAQADQVIVVDNGKIVGTGTHETLLADCPTYAEFAASQSLSA
FT TVGGVG"
FT misc_feature complement(39544..39588)
FT /note="PS00211 ABC transporters family signature"
FT misc_feature complement(39880..39903)
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature complement(40270..40314)
FT /note="PS00211 ABC transporters family signature"
FT misc_feature complement(40858..40893)
FT /note="PS00136 Serine proteases, subtilase family, aspartic
FT acid active site"
FT CDS 41154..41711
FT /transl_table=11
FT /gene="lprB"
FT /locus_tag="Rv1274"
FT /product="POSSIBLE LIPOPROTEIN LPRB"
FT /function="UNKNOWN"
FT /note="Rv1274, (MTCY50.08c), len: 185 aa. Possible lprB,
FT lipoprotein; contains possible N-terminal signal sequence
FT and appropriately positioned prokaryotic lipoprotein lipid
FT attachment site (PS00013) . Some similarity to Rv1275."
FT /db_xref="GOA:Q11045"
FT /db_xref="UniProtKB/Swiss-Prot:Q11045"
FT /protein_id="CAB00906.1"
FT /translation="MRRKVRRLTLAVSALVALFPAVAGCSDSGDNKPGATIPSTPANAE
FT GRHGPFFPQCGGVSDQTVTELTRVTGLVNTAKNSVGCQWLAGGGILGPHFSFSWYRGSP
FT IGRERKTEELSRASVEDINIDGHSGFIAIGNEPSLGDSLCEVGIQFSDDFIEWSVSFSQ
FT KPFPLPCDIAKELTRQSIANSK"
FT CDS 41708..42250
FT /transl_table=11
FT /gene="lprC"
FT /locus_tag="Rv1275"
FT /product="POSSIBLE LIPOPROTEIN LPRC"
FT /function="UNKNOWN"
FT /note="Rv1275, (MTCY50.07c), len: 180 aa. Possible lprC,
FT lipoprotein; contains possible N-terminal signal sequence
FT and appropriately positioned prokaryotic lipoprotein lipid
FT attachment site (PS00013). Some similarity to Rv1274."
FT /db_xref="UniProtKB/TrEMBL:O86337"
FT /protein_id="CAB00916.1"
FT /translation="MRRVLVGAAALITALLVLTGCTKSISGTAVKAGGAGVPRNNNSQE
FT RYPNLLKECEVLTTDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQGS
FT LSNERKVAEGLKYQVETRAIQGVDSIVMRTGDPNGACGVASDAAGVVGWWVNPQAPGID
FT ACGQAIKLMELTLATNA"
FT CDS complement(42395..42871)
FT /transl_table=11
FT /locus_tag="Rv1276c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1276c, (MTCY50.06), len: 158 aa. Conserved
FT hypothetical protein, similar to AL096844|SCI28.03
FT hypothetical protein from Streptomyces coelicolor (172 aa),
FT FASTA scores: opt: 385, E(): 3.3e-19, (43.5% identity in
FT 161 aa overlap). Some similarity to P76502|SIXA_ECOLI
FT PHOSPHOHISTIDINE PHOSPHATASE SIXA (161 aa), FASTA scores:
FT opt: 146, E(): 0.0047, (31.9% identity in 116 aa overlap).
FT BELONGS TO THE SIXA FAMILY OF PHOSPHATASES."
FT /db_xref="GOA:Q11043"
FT /db_xref="InterPro:IPR013078"
FT /db_xref="UniProtKB/Swiss-Prot:Q11043"
FT /protein_id="CAB00905.1"
FT /translation="MRHAKSAYPDGIADHDRPLAPRGIREAGLAGGWLRANLPAVDAVL
FT CSTATRARQTLAHTGIDAPARYAERLYGAAPGTVIEEINRVGDNVTTLLVVGHEPTTSA
FT LAIVLASISGTDAAVAERISEKFPTSGIAVLRVAGHWADVEPGCAALVGFHVPR"
FT CDS 43121..44374
FT /transl_table=11
FT /locus_tag="Rv1277"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1277, (MTCY50.05c), len: 417 aa. Conserved
FT hypothetical protein, some similarity to
FT 3914967|O68033|SBCD_RHOCA EXONUCLEASE SBCD HOMOLOG from
FT Rhodobacter capsulatus (405 aa). May be sbcD protein (see
FT Mizrahi & Andersen 1998)"
FT /db_xref="GOA:Q50699"
FT /db_xref="InterPro:IPR004843"
FT /db_xref="InterPro:IPR014577"
FT /db_xref="UniProtKB/TrEMBL:Q50699"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB00917.1"
FT /translation="MSPRPGPAGRGPAPCRCADLHSLCVDSHALRRDGMRFLHTADWQL
FT GMTRHFLAGDAQPRYSAARRDAVAGLKALAADVGAEFVVVAGDVFEHNQLAPQIVGQSL
FT EAMRVIGLPVYLLPGNHDPLDASSVYTSTLFRAERPDNVVVLDRAGVHEVRPGVQIVAA
FT PWRSKAPTTDPVAEVLAGLPTDAAIRLLVAHGGVDALDPDHDKPSLIRLAALDDALTRQ
FT AIHYVALGDKHSLTQVGSSGRVWYSGAPEVTNFDDVEPDPGHVLVVDIDESDPRHPVTV
FT DARRIGRWRFVTLHHQVDTSRDIADLDLNLDLMTDKDRTVVRLALTGSLTVTDRAALDT
FT CLDKYARLFAWLGLWERHTDLAVIPVDAEFTDLGIGGFAAAAVDELVATARGGDDESAV
FT DAQAALALLLRLADRGAA"
FT CDS 44371..46998
FT /transl_table=11
FT /locus_tag="Rv1278"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1278, (MTCY50.04c), len: 875. Hypothetical unknown
FT protein, possible coiled-coil regions, contains PS00017
FT ATP/GTP-binding site motif A."
FT /db_xref="UniProtKB/Swiss-Prot:P64795"
FT /protein_id="CAB00904.1"
FT /translation="MKLHRLALTNYRGIAHRDVEFPDHGVVVVCGANEIGKSSMVEALD
FT LLLEYKDRSTKKEVKQVKPTNADVGSEVIAEISSGPYRFVYRKRFHKRCETELTVLAPR
FT REQLTGDEAHERVRTMLAETVDTELWHAQRVLQAASTAAVDLSGCDALSRALDLAAGDD
FT AALSGTESLLIERIEAEYARYFTPTGRPTGEWSAAVSRLAAAEAAVADCAAAVAEVDDG
FT VRRHTELTEQVAELSQQLLAHQLRLEAARVAAEKIAAITDDAREAKLIATAAAATSGAS
FT TAAHAGRLGLLTEIDTRTAAVVAAEAKARQAADEQATARAEAEACDAALTEATQVLTAV
FT RLRAESARRTLDQLADCEEADRLAARLARIDDIEGDRDRVCAELSAVTLTEELLSRIER
FT AAAAVDRGGAQLASISAAVEFTAAVDIELGVGDQRVSLSAGQSWSVTATGPTEVKVPGV
FT LTARIVPGATALDFQAKYAAAQQELADALAAGEVADLAAARSADLCRRELLSRRDQLTA
FT TLAGLCGDEQVDQLRSRLEQLCAGQPAELDLVSTDTATARAELDAVEAARIAAEKDCET
FT RRQIAAGAARRLAETSTRATVLQNAAAAESAELGAAMTRLACERASVGDDELAAKAEAD
FT LRVLQTAEQRVIDLADELAATAPDAVAAELAEAADAVELLRERHDEAIRALHEVGVELS
FT VFGTQGRKGKLDAAETEREHAASHHARVGRRARAARLLRSVMARHRDTTRLRYVEPYRA
FT ELHRLGRPVFGPSFEVEVDTDLRIRSRTLDDRTVPYECLSGGAKEQLGILARLAGAALV
FT AKEDAVPVLIDDALGFTDPERLAKMGEVFDTIGADGQVIVLTCSPTRYGGVKGAHRIDL
FT DAIQ"
FT misc_feature 44461..44484
FT /note="PS00017 ATP/GTP-binding site motif A"
FT CDS 47019..48605
FT /transl_table=11
FT /locus_tag="Rv1279"
FT /product="PROBABLE DEHYDROGENASE FAD flavoprotein GMC
FT oxidoreductase"
FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT METABOLISM, PROBABLY ELECTRON-TRANSFER-LINKED."
FT /EC_number="1.1.-.-"
FT /note="Rv1279, (MTCY50.03c), len: 528 aa. Probable
FT dehydrogenase, FAD flavoprotein GMC oxidoreductase (EC
FT 1.1.-.-), similar to several e.g. dBETA_ECOLI|P17444
FT choline dehydrogenase from Escherichia coli (556 aa), FASTA
FT scores, opt: 1047, E(): 0, (37.7% identity in 541 aa
FT overlap). Similar to Rv0697 putative Mycobacterium
FT tuberculosis GMC oxidoreductase. Contains PS00623 GMC
FT oxidoreductases signature 1, and PS00624 GMC
FT oxidoreductases signature 2. BELONGS TO THE GMC
FT OXIDOREDUCTASES FAMILY."
FT /db_xref="GOA:P64263"
FT /db_xref="InterPro:IPR000172"
FT /db_xref="InterPro:IPR007867"
FT /db_xref="InterPro:IPR012132"
FT /db_xref="UniProtKB/Swiss-Prot:P64263"
FT /protein_id="CAB00903.1"
FT /translation="MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFI
FT GVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVRGFASDYD
FT EWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWL
FT AAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATAT
FT RVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDID
FT TVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLISYLLRRRGMLTSNVGEAYGF
FT VRSRPELKLPDLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAK
FT PVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELA
FT LATCSHTLYHPMGTCRMGSDEASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVL
FT IGEKAADLIRS"
FT misc_feature 47259..47330
FT /note="PS00623 GMC oxidoreductases signature 1"
FT misc_feature 47784..47828
FT /note="PS00624 GMC oxidoreductases signature 2"
FT CDS complement(48622..50397)
FT /transl_table=11
FT /gene="oppA"
FT /locus_tag="Rv1280c"
FT /product="PROBABLE PERIPLASMIC OLIGOPEPTIDE-BINDING
FT LIPOPROTEIN OPPA"
FT /function="INVOLVED IN ACTIVE TRANSPORT OF OLIGOPEPTIDE
FT ACROSS THE MEMBRANE (IMPORT). THIS PROTEIN IS A COMPONENT
FT OF THE OLIGOPEPTIDE PERMEASE, A BINDING PROTEIN-DEPENDENT
FT TRANSPORT SYSTEM; IT BINDS PEPTIDES UP TO FIVE AMINO ACIDS
FT LONG WITH HIGH AFFINITY."
FT /note="Rv1280c, (MTCY50.02), len: 591 aa. Probable oppA,
FT oligopeptide-binding lipoprotein component of peptide
FT transport system (see citation below), sharing some
FT similarity to other periplasmic solute binding proteins
FT e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding
FT protein from Salmonella typhimurium (542 aa), FASTA scores:
FT E(): 5.1e-05, (22.1% identity in 458 aa overlap); etc. Also
FT similar to Rv1166 and Rv2585c from Mycobacterium
FT tuberculosis. Has possible N-terminal signal sequence and
FT prokaryotic lipoprotein lipid attachment site (PS00013).
FT BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING
FT PROTEIN FAMILY 5."
FT /db_xref="GOA:P66771"
FT /db_xref="InterPro:IPR000914"
FT /db_xref="UniProtKB/Swiss-Prot:P66771"
FT /protein_id="CAB00902.1"
FT /translation="MADRGQRRGCAPGIASALRASFQGKSRPWTQTRYWAFALLTPLVV
FT AMVLTGCSASGTQLELAPTADRRAAVGTTSDINQQDPATLQDGGNLRLSLTDFPPNFNI
FT LHIDGNNAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTRTAPQVVTYTINPEAV
FT WSDGTPITWRDIASQIHAISGADKAFEIASSSGAERVASVTRGVDDRQAVVTFAKPYAE
FT WRGMFAGNGMLLPASMTATPEAFNKGQLDGPGPSAGPFVVSALDRTAQRIVLTRNPRWW
FT GARPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAARTKGISIRRAPGPSWY
FT HFTLNGAPGSILADKALRLAIAKGIDRYTIARVAQYGLTSDPVPLNNHVFVAGQDGYQD
FT NSGVVAYNPEQAKRELDALGWRRSGAFREKDGRQLVIRDLFYDAQSTRQFAQIAQHTLA
FT QIGVKLELQAKSGSGFFSDYVNVGAFDIAQFGWVGDAFPLSSLTQIYASDGESNFGKIG
FT SPQIDAAIERTLAELDPGKARALANQVDELIWAEGFSLPLTQSPGTVAVRSTLANFGAT
FT GLADLDYTAIGFMRR"
FT CDS complement(50390..52228)
FT /transl_table=11
FT /gene="oppD"
FT /locus_tag="Rv1281c"
FT /product="PROBABLE OLIGOPEPTIDE-TRANSPORT ATP-BINDING
FT PROTEIN ABC TRANSPORTER OPPD"
FT /function="INVOLVED IN ACTIVE TRANSPORT OF OLIGOPEPTIDE
FT ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR ENERGY
FT COUPLING TO THE TRANSPORT SYSTEM."
FT /note="Rv1281c, (MTCY50.01), len: 612 aa. Probable oppD,
FT oligopeptide-transport ATP-binding protein ABC transporter
FT (see citation below), similar to others e.g.
FT DPPD_BACSU|P26905 dipeptide transport ATP-binding protein
FT from Bacillus subtilis (335 aa), FASTA scores: opt: 983,
FT E(): 0, (48.6% identity in 319 aa overlap); etc. Contains 2
FT x PS00017 ATP/GTP-binding site motif A (P-loop); 2 x
FT PS00211 ABC transporters family signature.BELONGS TO THE
FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)."
FT /db_xref="GOA:P63395"
FT /db_xref="InterPro:IPR003439"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR010066"
FT /db_xref="InterPro:IPR013563"
FT /db_xref="InterPro:IPR017871"
FT /db_xref="UniProtKB/Swiss-Prot:P63395"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB00901.1"
FT /translation="MSPLLEVTDLAVTFRTDGDPVTAVRGISYRVEPGEVVAMVGESGS
FT GKSAAAMAVVGLLPEYAQVRGSVRLQGTELLGLADNAMSRFRGKAIGTVFQDPMSALTP
FT VYTVGDQIAEAIEVHQPRVGKKAARRRAVELLDLVGISQPQRRSRAFPHELSGGERQRV
FT VIAIAIANDPDLLICDEPTTALDVTVQAQILDVLKAARDVTGAGVLIITHDLGVVAEFA
FT DRALVMYAGRVVESAGVNDLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAPPSLAG
FT LAPGCPFAPRCPLVIDECLTAEPELLDVATDHRAACIRTELVTGRSAADIYRVKTEARP
FT AALGDASVVVRVRHLVKTYRLAKGVVLRRAIGEVRAVDGISLELRQGRTLGIVGESGSG
FT KSTTLHEILELAAPQSGSIEVLGTDVATLGTAERRSLRRDIQVVFQDPVASLDPRLPVF
FT DLIAEPLQANGFGKNETHARVAELLDIVGLRHGDASRYPAEFSGGQKQRIGIARALALQ
FT PKILALDEPVSALDVSIQAGIINLLLDLQEQFGLSYLFVSHDLSVVKHLAHQVAVMLAG
FT TVVEQGDSEEVFGNPKHEYTRRLLGAVPQPDPARRG"
FT misc_feature complement(50687..50731)
FT /note="PS00211 ABC transporters family signature"
FT misc_feature complement(51026..51049)
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature complement(51722..51766)
FT /note="PS00211 ABC transporters family signature"
FT misc_feature complement(52085..52108)
FT /note="PS00017 ATP/GTP-binding site motif A"
FT CDS complement(52225..53100)
FT /transl_table=11
FT /gene="oppC"
FT /locus_tag="Rv1282c"
FT /product="PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE
FT PROTEIN ABC TRANSPORTER OPPC"
FT /function="INVOLVED IN ACTIVE TRANSPORT OF OLIGOPEPTIDE
FT ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE
FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE."
FT /note="Rv1282c, (MTCY373.01c-MTCY3H3.01), len: 291 aa.
FT Probable oppC, oligopeptide-transport integral membrane
FT protein ABC transporter (see citation below), similar to
FT other integral membrane proteins e.g. OPPC_ECOLI|P77664
FT oligopeptide transport system permease from Escherichia
FT coli (302 aa), FASTA scores: E(): 4.6e-33, (40.7% identity
FT in 275 aa overlap); etc. Also similar to Rv3664c|DPPC
FT probable peptide-transport integral membrane protein from
FT Mycobacterium tuberculosis."
FT /db_xref="GOA:P66964"
FT /db_xref="InterPro:IPR000515"
FT /db_xref="UniProtKB/Swiss-Prot:P66964"
FT /protein_id="CAB01002.1"
FT /translation="MTEFASRRTLVVRRFLRNRAAVASLAALLLLFVSAYALPPLLPYS
FT YDDLDFNALLQPPGTKHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAVISTGIAATVGA
FT ISGYFGGWRDRTLMWVVDLLLVVPSFILIAIVTPRTKNSANIMFLVLLLAGFGWMISSR
FT MVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVAAAILAETGL
FT SFLGFGIQPPDVSLGTLIADGTASATAFPWVFLFPASILVLILVCANLTGDGLRDALDP
FT ASRSLRRGVR"
FT CDS complement(53097..54074)
FT /transl_table=11
FT /gene="oppB"
FT /locus_tag="Rv1283c"
FT /product="PROBABLE OLIGOPEPTIDE-TRANSPORT INTEGRAL MEMBRANE
FT PROTEIN ABC TRANSPORTER OPPB"
FT /function="INVOLVED IN ACTIVE TRANSPORT OF OLIGOPEPTIDE
FT ACROSS THE MEMBRANE (IMPORT). RESPONSIBLE FOR THE
FT TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE."
FT /note="Rv1283c, (MTCY373.02c), len: 325 aa. Probable oppB,
FT oligopeptide-transport integral membrane protein ABC
FT transporter (see citation below), similar to other integral
FT membrane proteins e.g. DPPB_ECOLI|P37316 dipeptide
FT transport system permease protein from Escherichia coli
FT (339 aa), FASTA scores: opt: 402, E(): 3.4e-20, (31.0%
FT identity in 345 aa overlap); etc. Also similar to
FT Rv3665c|DppB probable peptide-transport integral membrane
FT protein from Mycobacterium tuberculosis. Contains PS00402
FT Binding-protein-dependent transport systems inner membrane
FT comp signature."
FT /db_xref="GOA:P66966"
FT /db_xref="InterPro:IPR000515"
FT /db_xref="UniProtKB/Swiss-Prot:P66966"
FT /protein_id="CAA97749.1"
FT /translation="MTRYLARRLLNYLVLLALASFLTYCLTSLAFSPLESLMQRSPRPP
FT QAVIDAKAHDLGLDRPILARYANWVSHAVRGDFGTTITGQPVGTELGRRIGVSLRLLVV
FT GSVFGTVAGVVIGAWGAIRQYRLSDRVMTTLALLVLSTPTFVVANLLILGALRVNWAVG
FT IQLFDYTGETSPGVAGGVWDRLGDRLQHLILPSLTLALAAAAGFSRYQRNAMLDVLGQD
FT FIRTARAKGLTRRRALLKHGLRTALIPMATLFAYGVAGLVTGAVFVEKIFGWHGMGEWM
FT VRGISTQDTNIVAAITVFSGAVVLLAGLLSDVIYAALDPRVRVS"
FT misc_feature complement(53343..53429)
FT /note="PS00402 Binding-protein-dependent transport systems
FT inner membrane comp signature."
FT CDS 54281..54772
FT /transl_table=11
FT /locus_tag="Rv1284"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1284, (MTCY373.03), len: 163 aa. Conserved
FT hypothetical protein, similar to AL109663|SC4A10.26
FT hypothetical protein from Streptomyces coelicolor (167 aa),
FT FASTA scores: opt: 567, E(): 1.5e-32, (53.4% identity in
FT 163 aa overla); shows some similarity to hypothetical
FT protein from Methanobacterium thermoautotrophicum. Weak
FT similarity to carbonic anhydrases e.g.
FT U51624|MTU516242|P17582 Methanothermobacter
FT thermautotrophicus (171 aa), FASTA score: opt: 305, E(): 1
FT .2e-14, (35.2% identity in 165 aa overlap)."
FT /db_xref="GOA:P64797"
FT /db_xref="InterPro:IPR001765"
FT /db_xref="PDB:1YLK"
FT /db_xref="UniProtKB/Swiss-Prot:P64797"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97750.1"
FT /translation="MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRM
FT LGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRA
FT IQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
FT "
FT CDS 54866..55864
FT /transl_table=11
FT /gene="cysD"
FT /locus_tag="Rv1285"
FT /product="PROBABLE SULFATE ADENYLYLTRANSFERASE SUBUNIT 2
FT CYSD"
FT /function="INVOLVED IN SULFATE ACTIVATION PATHWAY. FIRST
FT STEP IN THE SULFATE ACTIVATION PATHWAY. THIS REACTION
FT OCCURS EARLY IN THE REDUCTIVE BRANCH OF THE CYSTEINE
FT BIOSYNTHETIC PATHWAY [CATALYTIC ACTIVITY :ATP + SULFATE =
FT DIPHOSPHATE + ADENYLYLSULFATE]"
FT /EC_number="2.7.7.4"
FT /note="Rv1285, (MTCY373.04), len: 332 aa. Probable cysD,
FT sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) (see
FT Wooff et al., 2002), homology suggests start site at aa 24
FT or 28, similar to e.g. CYSD_ECOLI|P21156 sulfate adenylate
FT transferase subunit 2 from Escherichia coli (302 aa), FASTA
FT score: opt: 973, E():0, (52.5% identity in 303 aa overlap).
FT Also similar to Mycobacterium tuberculosis Rv2392,
FT 3'-phosphoadenylylsulfate reductase. BELONGS TO THE PAPS
FT REDUCTASE FAMILY. CYSD SUBFAMILY. Thought to be
FT differentially expressed within host cells (see Triccas et
FT al., 1999)."
FT /db_xref="GOA:P65670"
FT /db_xref="InterPro:IPR002500"
FT /db_xref="InterPro:IPR011784"
FT /db_xref="InterPro:IPR014729"
FT /db_xref="UniProtKB/Swiss-Prot:P65670"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97751.1"
FT /translation="MAITINMVNPTGFIRYEDVEQEAMTSDVTVGPAPGQYQLSHLRLL
FT EAEAIHVIREVAAEFERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGHNFDE
FT VIATRDELVAAAGVRLVVASVQDDIDAGRVVETIPSRNPIQTVTLLRAIRENQFDAAFG
FT GARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEF
FT DIWSYIGAEQVRLPSIYFAHRRKVFQRDGMLLAVHRHMQPRADEPVFEATVRFRTVGDV
FT TCTGCVESSASTVAEVIAETAVARLTERGATRADDRISEAGMEDRKRQGYF"
FT CDS 55864..57708
FT /transl_table=11
FT /gene="cysN"
FT /locus_tag="Rv1286"
FT /product="PROBABLE BIFUNCTIONAL ENZYME CYSN/CYSC: SULFATE
FT ADENYLTRANSFERASE (SUBUNIT 1) + ADENYLYLSULFATE KINASE"
FT /function="ATP SULFURYLASE MAY BE THE GTPASE, REGULATING
FT ATP SULFURYLASE ACTIVITY [CATALYTIC ACTIVITY 1: ATP +
FT SULFATE = DIPHOSPHATE + ADENYLYLSULFATE] AND APS KINASE
FT CATALYZES THE SYNTHESIS OF ACTIVATED SULFATE [CATALYTIC
FT ACTIVITY 2: ATP + ADENYLYLSULFATE = ADP + 3'-
FT PHOSPHOADENYLYLSULFATE]. FIRST AND SECOND STEPS IN THE
FT SULFATE ACTIVATION PATHWAY. THESE REACTIONS OCCURS EARLY IN
FT THE REDUCTIVE BRANCH OF THE CYSTEINE BIOSYNTHETIC PATHWAY."
FT /EC_number="2.7.7.4"
FT /EC_number="2.7.1.25"
FT /note="Rv1286, (MTCY373.05), len: 614 aa. Probable
FT cysN/cysC bifunctional enzyme, sulfate adenylyltransferase
FT subunit 1 (EC 2.7.7.4) and Adenylylsulfate kinase (EC
FT 2.7.1.25) (see Wooff et al., 2002), similar to
FT CYSN_ECOLI|P23845 sulfate adenylate transferase subunit 1
FT from Escherichia coli (475 aa), FASTA scores: opt: 1291,
FT E():0, (50.2% identity in 428 aa overlap). Contains 2 x
FT PS00017 ATP/GTP-binding site motif A, PS00301 GTP-binding
FT elongation factors signature."
FT /db_xref="GOA:Q10600"
FT /db_xref="InterPro:IPR000795"
FT /db_xref="InterPro:IPR002891"
FT /db_xref="InterPro:IPR004161"
FT /db_xref="InterPro:IPR009000"
FT /db_xref="InterPro:IPR009001"
FT /db_xref="InterPro:IPR011779"
FT /db_xref="UniProtKB/Swiss-Prot:Q10600"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97752.1"
FT /translation="MTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVEQTSKD
FT RGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGAS
FT TAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVLAVNKMDLLGWDQEKFDAIRDEFH
FT AFAARLDVQDVTSIPISALHGDNVVTKSDQTPWYEGPSLLSHLEDVYIAGDRNMVDVRF
FT PVQYVIRPHTLEHQDHRSYAGTVASGVMRSGDEVVVLPIGKTTRITAIDGPNGPVAEAF
FT PPMAVSVRLADDIDISRGDMIARTHNQPRITQEFDATVCWMADNAVLEPGRDYVVKHTT
FT RTVRARIAGLDYRLDVNTLHRDKTATALKLNELGRVSLRTQVPLLLDEYTRNASTGSFI
FT LIDPDTNGTVAAGMVLRDVSARTPSPNTVRHRSLVTAQDRPPRGKTVWFTGLSGSGKSS
FT VAMLVERKLLEKGISAYVLDGDNLRHGLNADLGFSMADRAENLRRLSHVATLLADCGHL
FT VLVPAISPLAEHRALARKVHADAGIDFFEVFCDTPLQDCERRDPKGLYAKARAGEITHF
FT TGIDSPYQRPKNPDLRLTPDRSIDEQAQEVIDLLESSS"
FT misc_feature 55894..55917
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature 56035..56082
FT /note="PS00301 GTP-binding elongation factors signature"
FT misc_feature 57211..57234
FT /note="PS00017 ATP/GTP-binding site motif A"
FT CDS 57762..58247
FT /transl_table=11
FT /locus_tag="Rv1287"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1287, (MTCY373.06), len: 161 aa. Conserved
FT hypothetical protein, similar to VJEB family of proteins
FT e.g. FASTA score: P44675|Y379_HAEIN HYPOTHETICAL PROTEIN
FT HI0379 (150 aa), FASTA scores: opt: 213, E(): 2.5e-08,
FT (30.0% identity in 130 aa overlap) and YJEB_ECOLI|P21498
FT hypothetical 15.6 kDa protein in pura-vacb (141 aa), opt:
FT 167, E(): 9.5e-06, (25.0% identity in 136 aa overlap).
FT BELONGS TO THE UPF0074 (RFF2) FAMILY."
FT /db_xref="GOA:P67159"
FT /db_xref="InterPro:IPR000944"
FT /db_xref="UniProtKB/Swiss-Prot:P67159"
FT /protein_id="CAA97753.1"
FT /translation="MRMSAKAEYAVRAMVQLATAASGTVVKTDDLAAAQGIPPQFLVDI
FT LTNLRTDRLVRSHRGREGGYELARPGTEISIADVLRCIDGPLASVRDIGLGDLPYSGPT
FT TALTDVWRALRASMRSVLEETTLADVAGGALPEHVAQLADDYRAQESTRHGASRHGD"
FT CDS 58305..59675
FT /transl_table=11
FT /locus_tag="Rv1288"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1288, (MTCY373.07), len: 456 aa. Conserved
FT hypothetical protein, some similarity to A85B_MYCTU|P31952
FT antigen 85-b precursor (85b) (325 aa), FASTA scores: opt:
FT 199, E(): 2.7e-06, (24.7% identity in 279 aa overlap). Also
FT similar to Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (related
FT to antigen 85 complex) from Corynebacterium glutamicum (657
FT aa), FASTA scores: opt: 280, E(): 1.9e-10, (26.4% identity
FT in 352 aa overlap). SEEMS TO CONTAIN 3 LYSM REPEATS"
FT /db_xref="GOA:Q10614"
FT /db_xref="InterPro:IPR000801"
FT /db_xref="InterPro:IPR002482"
FT /db_xref="InterPro:IPR018392"
FT /db_xref="UniProtKB/Swiss-Prot:Q10614"
FT /protein_id="CAA97754.1"
FT /translation="MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVG
FT QRLIMPDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMPDF
FT TRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGFGLR
FT IVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQDFRT
FT FDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIEANFRT
FT YAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAV
FT LDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFDSVNETQVL
FT AGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGAAAERAD"
FT CDS 59724..60356
FT /transl_table=11
FT /locus_tag="Rv1289"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1289, (MTCY373.08), len: 210 aa. Hypothetical
FT unknown protein."
FT /db_xref="UniProtKB/Swiss-Prot:P64799"
FT /protein_id="CAA97755.1"
FT /translation="MCVSVGESVAQSLQQWDRKLWDVAMLHACNAVDETGRKRYPTLGV
FT GTRFRTALRDSLDIYGVMATPGVDLEKTRFPVGVRSDLLPDKRPDIADVLYGIHRWLHG
FT HADESSVEFEVSPYVNASAALRIANDGKIQLPKSAILGLLAVAVFAPENKGEVIPPDYQ
FT LSWYDHVFFISVWWGWQDHFREIVNVDRASLVALDFGDLWNGWTPVG"
FT CDS complement(60439..62004)
FT /transl_table=11
FT /locus_tag="Rv1290c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN VIRULENCE."
FT /note="Rv1290c, (MTCY373.09c), len: 521 aa. Conserved
FT hypothetical protein (see citation below), similar to
FT AL031013|SC8A6.09 hypothetical protein from Streptomyces
FT coelicolor (443 aa), FASTA scores: opt: 371, E(): 9.5e-17,
FT (28.3% identity in 446 aa overlap)."
FT /db_xref="GOA:P0A5E3"
FT /db_xref="InterPro:IPR018723"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5E3"
FT /protein_id="CAA97756.1"
FT /translation="MLQRSLGVNGRKLAMSARSAKRERKNASTAASKCYVVPPSARGWV
FT HAYSVTATSMLNRRKAILDYLQGAVWVLPTFGVAIGLGSGAVLSMIPVKSGTLIDKLMF
FT QGTPGDARGVLIVVSATMITTIGIVFSLTVLSLQIASSQFSVRLLRTFLRDVPNQVVLA
FT IFACTFAYSTGGLHTVGEHRDGGAFIPKVAVTGSLALAFVSIAALIYFLHHLMHSIQID
FT TIMDKVRLRTLGLVDQLYPESDTADRQVETPPSPPADAVPLLAPHSGYLQTVDVDDIAE
FT LAAASRYTALLVTFVGDYVTAGGLLGWCWRRGTAPGAPGSDFPQRCLRHVHIGFERTLQ
FT QDIRFGLRQMVDIALRALSPALNDPYTAIQVVHHLSAVESVLASRALPDDVRRDRAGEL
FT LFWLPYPSFATYLHVGCAQIRRYGSREPLVLTALLQLLSAVAQNCVDPSRRVAVQTQIA
FT LVVRAAQREFADESDRAMVLGAAARATEVVERPGTLAPPPSTFGQVAAAQAAASTIRSA
FT DRDG"
FT CDS 62015..62329
FT /transl_table=11
FT /locus_tag="Rv1290A"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1290A, len: 104 aa. Hypothetical unknown protein,
FT equivalent to AAK45590 from Mycobacterium tuberculosis
FT strain CDC1551 (122 aa) but shorter 18 aa."
FT /db_xref="UniProtKB/TrEMBL:Q79FQ6"
FT /protein_id="CAE55375.1"
FT /translation="MLALHGLSEGVSGSGGSGGRWGAGEVLEGARIGVIADGVSCFPTK
FT ADCRRIRGVPVFDGYTRMVARLMGSLAVLRSVSIPKGYRDFGFGSLRAVAPKNCPDVSG
FT "
FT CDS complement(62456..62791)
FT /transl_table=11
FT /locus_tag="Rv1291c"
FT /product="CONSERVED HYPOTHETICAL SECRETED PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1291c, (MTCY373.10c), len: 111 aa. Conserved
FT hypothetical secreted protein, similar to others in
FT Mycobacterium tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU
FT HYPOTHETICAL 11.6 kDa PROTEIN (113 aa), FASTA score: opt:
FT 246, E(): 1.7e-09, (40.0% identity in 110 aa overlap);
FT Rv1804c, Rv1810, Rv0622, etc."
FT /db_xref="InterPro:IPR007969"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5E5"
FT /protein_id="CAA97761.1"
FT /translation="MFTRRFAASMVGTTLTAATLGLAALGFAGTASASSTDEAFLAQLQ
FT ADGITPPSAARAIKDAHAVCDALDEGHSAKAVIKAVAKATGLSAKGAKTFAVDAASAYC
FT PQYVTSS"
FT tRNA complement(63150..63222)
FT /gene="tRNA-Arg(CCG)"
FT /product="transfer RNA-Arg(CCG)"
FT /anticodon=(pos:63187..63189,aa:Arg)
FT CDS 63336..64988
FT /transl_table=11
FT /gene="argS"
FT /locus_tag="Rv1292"
FT /product="PROBABLE ARGINYL-TRNA SYNTHETASE ARGS (ARGRS)
FT (Arginine--tRNA ligase)"
FT /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC
FT ACTIVITY: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate
FT + L-arginyl-tRNA(Arg)]."
FT /EC_number="6.1.1.19"
FT /note="Rv1292, (MTCY373.12), len: 550 aa. Probable argS,
FT Arginyl-tRNA synthetase (EC 6.1.1.19), highly similar to
FT SYR_MYCLE|P45840 Mycobacterium leprae (550 aa), FASTA
FT scores: opt: 3115, E(): 0, (84.9% identity in 550 aa
FT overlap). Contains PS00178 Aminoacyl-transfer RNA
FT synthetases class-I signature. BELONGS TO CLASS-I
FT AMINOACYL-TRNA SYNTHETASE FAMILY."
FT /db_xref="GOA:P67569"
FT /db_xref="InterPro:IPR001278"
FT /db_xref="InterPro:IPR001412"
FT /db_xref="InterPro:IPR005148"
FT /db_xref="InterPro:IPR008909"
FT /db_xref="InterPro:IPR009080"
FT /db_xref="InterPro:IPR014729"
FT /db_xref="InterPro:IPR015945"
FT /db_xref="UniProtKB/Swiss-Prot:P67569"
FT /protein_id="CAA97757.1"
FT /translation="MTPADLAELLKATAAAVLAERGLDASALPQMVTVERPRIPEHGDY
FT ASNLAMQLAKKVGTNPRELAGWLAEALTKVDGIASAEVAGPGFINMRLETAAQAKVVTS
FT VIDAGHSYGHSLLLAGRKVNLEFVSANPTGPIHIGGTRWAAVGDALGRLLTTQGADVVR
FT EYYFNDHGAQIDRFANSLIAAAKGEPTPQDGYAGSYITNIAEQVLQKAPDALSLPDAEL
FT RETFRAIGVDLMFDHIKQSLHEFGTDFDVYTHEDSMHTGGRVENAIARLRETGNIYEKD
FT GATWLRTSAFGDDKDRVVIKSDGKPAYIAGDLAYYLDKRQRGFDLCIYMLGADHHGYIA
FT RLKAAAAAFGDDPATVEVLIGQMVNLVRDGQPVRMSKRAGTVLTLDDLVEAIGVDAARY
FT SLIRSSVDTAIDIDLALWSSASNENPVYYVQYAHARLSALARNAAELALIPDTNHLELL
FT NHDKEGTLLRTLGEFPRVLETAASLREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEQP
FT TDLHTARLALCQATRQVIANGLAIIGVTAPERM"
FT misc_feature 63729..63758
FT /note="PS00178 Aminoacyl-transfer RNA synthetases class-I
FT signature"
FT CDS 64985..66328
FT /transl_table=11
FT /gene="lysA"
FT /locus_tag="Rv1293"
FT /product="PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP
FT DECARBOXYLASE)"
FT /function="INVOLVED IN BIOSYNTHESIS OF LYSINE (LAST STEP)
FT [CATALYTIC ACTIVITY : MESO-2,6-DIAMINOHEPTANEDIOATE =
FT L-LYSINE + CO(2)]."
FT /EC_number="4.1.1.20"
FT /note="Rv1293, (MTCY373.13), len: 447 aa. Probable lysA,
FT diaminopimelate decarboxylase (EC 4.1.1.20) (see citation
FT below), almost identical to DCDA_MYCTU|P31848. Contains
FT PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P
FT attachment site, PS00879 Orn/DAP/Arg decarboxylases family
FT 2 signature 2. BELONGS TO FAMILY 2 OF ORNITHINE, DAP, AND
FT ARGININE DECARBOXYLASES."
FT /db_xref="GOA:P0A5M4"
FT /db_xref="InterPro:IPR000183"
FT /db_xref="InterPro:IPR002986"
FT /db_xref="InterPro:IPR009006"
FT /db_xref="PDB:1HKV"
FT /db_xref="PDB:1HKW"
FT /db_xref="PDB:2O0T"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5M4"
FT /protein_id="CAA97758.1"
FT /translation="MNELLHLAPNVWPRNTTRDEVGVVCIAGIPLTQLAQEYGTPLFVI
FT DEDDFRSRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGELAVALHA
FT SFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVLVRLT
FT VGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVD
FT GFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAELAAKLGT
FT IVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMS
FT DNIRTALYGAQYDVRLVSRVSDAPPVPARLVGKHCESGDIIVRDTWVPDDIRPGDLVAV
FT AATGAYCYSLSSRYNMVGRPAVVAVHAGNARLVLRRETVDDLLSLEVR"
FT misc_feature 65189..65245
FT /note="PS00878 Orn/DAP/Arg decarboxylases family 2
FT pyridoxal-P attachment site"
FT misc_feature 65732..65764
FT /note="PS00879 Orn/DAP/Arg decarboxylases family 2
FT signature 2"
FT CDS 66332..67657
FT /transl_table=11
FT /gene="thrA"
FT /locus_tag="Rv1294"
FT /product="PROBABLE HOMOSERINE DEHYDROGENASE THRA"
FT /function="INVOLVED IN THE CONVERSION OF L-ASPARTATE TO
FT HOMOSERINE (THIRD STEP). HOMOSERINE PARTICIPATES IN THE
FT BIOSYNTHESIS OF THREONINE AND THEN ISOLEUCINE AND IN THE
FT BIOSYNTHESIS OF METHIONINE [CATALYTIC ACTIVITY :
FT L-HOMOSERINE + NAD(P)(+) = L-ASPARTATE 4-SEMIALDEHYDE +
FT NAD(P)H.]"
FT /EC_number="1.1.1.3"
FT /note="Rv1294, (MTCY373.14), len: 441 aa. Probable thrA
FT (hom), homoserine dehydrogenase (EC 1.1.1.3), highly
FT similar to DHOM_MYCLE|P46806 from Mycobacterium leprae (441
FT aa), FASTA scores: opt: 2437, E():0, (89.5% identity in 438
FT aa overlap). Contains PS00017 ATP/GTP-binding site motif A;
FT PS01042 Homoserine dehydrogenase signature. BELONGS TO THE
FT HOMOSERINE DEHYDROGENASE FAMILY."
FT /db_xref="GOA:P63629"
FT /db_xref="InterPro:IPR001342"
FT /db_xref="InterPro:IPR002912"
FT /db_xref="InterPro:IPR005106"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="InterPro:IPR016204"
FT /db_xref="InterPro:IPR019811"
FT /db_xref="UniProtKB/Swiss-Prot:P63629"
FT /protein_id="CAA97759.1"
FT /translation="MPGDEKPVGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLRG
FT IGVRRVTTDRGVPIELLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSVVT
FT ANKALLATSTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGT
FT TNYILSAMDSTGADYASALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTA
FT DDVYREGITKVTPADFGSAHALGCTIKLLSICERITTDEGSQRVSARVYPALVPLSHPL
FT AAVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPRESKY
FT AQLPVAPMGFIETRYYVSMNVADKPGVLSAVAAEFAKREVSIAEVRQEGVVDEGGRRVG
FT ARIVVVTHLATDAALSETVDALDDLDVVQGVSSVIRLEGTGL"
FT misc_feature 66611..66634
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature 66884..66952
FT /note="PS01042 Homoserine dehydrogenase signature"
FT CDS 67654..68736
FT /transl_table=11
FT /gene="thrC"
FT /locus_tag="Rv1295"
FT /product="PROBABLE THREONINE SYNTHASE THRC"
FT /function="INVOLVED IN THREONINE BIOSYNTHESIS [CATALYTIC
FT ACTIVITY : O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE +
FT PHOSPHATE]"
FT /EC_number="4.2.3.1"
FT /note="Rv1295, (MTCY373.15), len: 360 aa. Probable thrC,
FT threonine synthase (EC 4.2.99.2) (see Parish et al., 1999),
FT highly similar to THRC_MYCLE|P45837 Mycobacterium leprae
FT (360 aa), FASTA scores: opt: 2202, E(): 0, (93.9% identity
FT in 359 aa overlap). Contains PS00165 Serine/threonine
FT dehydratases pyridoxal-phosphate attachment site."
FT /db_xref="GOA:P66902"
FT /db_xref="InterPro:IPR000634"
FT /db_xref="InterPro:IPR001926"
FT /db_xref="InterPro:IPR004450"
FT /db_xref="PDB:2D1F"
FT /db_xref="UniProtKB/Swiss-Prot:P66902"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97760.1"
FT /translation="MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAAT
FT NLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAAYA
FT ARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVN
FT SVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPR
FT MLGTQAAGAAPLVLGEPVSHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEIL
FT AAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDM
FT PSVSPVPVDPVAVVEKLGLA"
FT misc_feature 67831..67872
FT /note="PS00165 Serine/threonine dehydratases
FT pyridoxal-phosphate attachment site"
FT CDS 68954..69904
FT /transl_table=11
FT /gene="thrB"
FT /locus_tag="Rv1296"
FT /product="PROBABLE HOMOSERINE KINASE THRB"
FT /function="THREONINE BIOSYNTHESIS FROM ASPARATE (FOURTH
FT STEP) [CATALYTIC ACTIVITY : ATP + L-HOMOSERINE = ADP +
FT O-PHOSPHO-L-HOMOSERINE]."
FT /EC_number="2.7.1.39"
FT /note="Rv1296, (MTCY373.16), len: 316 aa. Probable thrB,
FT homoserine kinase (EC 2.7.1.39) (see citation below),
FT highly similar to KHSE_MYCLE|P45836 from Mycobacterium
FT leprae (314 aa), FASTA scores, opt: 1657, E(): 0, (82.0%
FT identity in 311 aa overlap). Contains PS00639 Eukaryotic
FT thiol (cysteine) proteases histidine active site, and
FT PS00627 GHMP kinases putative ATP-binding domain."
FT /db_xref="GOA:P65224"
FT /db_xref="InterPro:IPR000870"
FT /db_xref="InterPro:IPR006203"
FT /db_xref="InterPro:IPR006204"
FT /db_xref="InterPro:IPR013750"
FT /db_xref="InterPro:IPR014721"
FT /db_xref="InterPro:IPR020568"
FT /db_xref="UniProtKB/Swiss-Prot:P65224"
FT /protein_id="CAA97729.1"
FT /translation="MVTQALLPSGLVASAVVAASSANLGPGFDSVGLALSLYDEIIVET
FT TDSGLTVTVDGEGGDQVPLGPEHLVVRAVQHGLQAAGVSAAGLAVRCRNAIPHSRGLGS
FT SAAAVVGGLAAVNGLVVQTDSSPSSDAELIQLASEFEGHPDNAAAAVLGGAVVSWTDHS
FT GDRPNYSAVSLRLHPDIRLFTAIPEQRSSTAETRVLLPAQVSHDDARFNVSRAALLVVA
FT LTERPDLLMAATEDLLHQPQRAAAMTASAEYLRLLRRHNVAAALSGAGPSLIALSTDSE
FT LPTDAVEFGAAKGFAVTELTVGEAVRWSPTVRVPG"
FT misc_feature 69173..69205
FT /note="PS00639 Eukaryotic thiol (cysteine) proteases
FT histidine active site"
FT misc_feature 69239..69274
FT /note="PS00627 GHMP kinases putative ATP-binding domain"
FT CDS 70161..71969
FT /transl_table=11
FT /gene="rho"
FT /locus_tag="Rv1297"
FT /product="PROBABLE TRANSCRIPTION TERMINATION FACTOR RHO
FT HOMOLOG"
FT /function="FACILITATES TRANSCRIPTION TERMINATION BY A
FT MECHANISM THAT INVOLVES RHO BINDING TO THE NASCENT RNA,
FT ACTIVATION OF RHO'S RNA-DEPENDENT ATPASE ACTIVITY, AND
FT RELEASE OF THE MRNA FROM THE DNA TEMPLATE"
FT /note="Rv1297, (MTCY373.17), len: 602 aa. Probable rho,
FT transcription termination factor homolog, highly similar to
FT many e.g. RHO_MYCLE|P45835 Mycobacterium leprae (610 aa),
FT FASTA scores: (81.5% identity in 612 aa overlap). CONTAINS
FT 1 RNA RECOGNITION MOTIF (RRM)."
FT /db_xref="GOA:P66028"
FT /db_xref="InterPro:IPR000194"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR004665"
FT /db_xref="InterPro:IPR011112"
FT /db_xref="InterPro:IPR011113"
FT /db_xref="InterPro:IPR011129"
FT /db_xref="UniProtKB/Swiss-Prot:P66028"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97730.1"
FT /translation="MTDTDLITAGESTDGKPSDAAATDPPDLNADEPAGSLATMVLPEL
FT RALANRAGVKGTSGMRKNELIAAIEEIRRQANGAPAVDRSAQEHDKGDRPPSSEAPATQ
FT GEQTPTEQIDSQSQQVRPERRSATREAGPSGSGERAGTAADDTDNRQGGQQDAKTEERG
FT TDAGGDQGGDQQASGGQQARGDEDGEARQGRRGRRFRDRRRRGERSGDGAEAELREDDV
FT VQPVAGILDVLDNYAFVRTSGYLPGPHDVYVSMNMVRKNGMRRGDAVTGAVRVPKEGEQ
FT PNQRQKFNPLVRLDSINGGSVEDAKKRPEFGKLTPLYPNQRLRLETSTERLTTRVIDLI
FT MPIGKGQRALIVSPPKAGKTTILQDIANAITRNNPECHLMVVLVDERPEEVTDMQRSVK
FT GEVIASTFDRPPSDHTSVAELAIERAKRLVEQGKDVVVLLDSITRLGRAYNNASPASGR
FT ILSGGVDSTALYPPKRFLGAARNIEEGGSLTIIATAMVETGSTGDTVIFEEFKGTGNAE
FT LKLDRKIAERRVFPAVDVNPSGTRKDELLLSPDEFAIVHKLRRVLSGLDSHQAIDLLMS
FT QLRKTKNNYEFLVQVSKTTPGSMDSD"
FT CDS 72120..72362
FT /transl_table=11
FT /gene="rpmE"
FT /locus_tag="Rv1298"
FT /product="PROBABLE 50S RIBOSOMAL PROTEIN L31 RPME"
FT /function="INVOLVED IN TRANSLATION"
FT /note="Rv1298, (MTCY373.18), len: 80 aa. Probable rpmE, 50s
FT ribosomal protein L31, highly similar to many e.g.
FT RL31_MYCLE|P45834 50s ribosomal protein L31 from
FT Mycobacterium leprae (84 aa), FASTA scores: opt: 490, E():
FT 5.5e-28, (89.6% identity in 77 aa overlap). Contains
FT PS01143 Ribosomal protein L31 signature. BELONGS TO THE
FT L31P FAMILY OF RIBOSOMAL PROTEINS."
FT /db_xref="GOA:P66187"
FT /db_xref="InterPro:IPR002150"
FT /db_xref="UniProtKB/Swiss-Prot:P66187"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97731.1"
FT /translation="MKSDIHPAYEETTVVCGCGNTFQTRSTKPGGRIVVEVCSQCHPFY
FT TGKQKILDSGGRVARFEKRYGKRKVGADKAVSTGK"
FT misc_feature 72231..72269
FT /note="PS01143 Ribosomal protein L31 signature"
FT CDS 72452..73525
FT /transl_table=11
FT /gene="prfA"
FT /locus_tag="Rv1299"
FT /product="PROBABLE PEPTIDE CHAIN RELEASE FACTOR 1 PRFA
FT (RF-1)"
FT /function="PEPTIDE CHAIN RELEASE FACTOR 1 DIRECTS THE
FT TERMINATION OF TRANSLATION IN RESPONSE TO THE PEPTIDE CHAIN
FT TERMINATION CODONS UAG AND UAA"
FT /note="Rv1299, (MTCY373.19), len: 357 aa. Probable prfA,
FT peptide chain release factor 1 (rf-1), highly similar to
FT many e.g. RF1_MYCLE|P45833 peptide chain release factor 1
FT (rf-1) from Mycobacterium leprae (357 aa), FASTA scores:
FT opt: 2047, E(): 0, (89.3% identity in 356 aa overlap); also
FT similar to Mycobacterium tuberculosis Rv3105c, prfB peptide
FT chain release factor 2. Contains PS00745 Prokaryotic-type
FT class I peptide chain release factors signature. BELONGS TO
FT THE PROKARYOTIC AND MITOCHONDRIAL RELEASE FACTORS FAMILY."
FT /db_xref="GOA:P66016"
FT /db_xref="InterPro:IPR000352"
FT /db_xref="InterPro:IPR004373"
FT /db_xref="InterPro:IPR005139"
FT /db_xref="UniProtKB/Swiss-Prot:P66016"
FT /protein_id="CAA97732.1"
FT /translation="MTQPVQTIDVLLAEHAELELALADPALHSNPAEARRVGRRFARLA
FT PIVATHRKLTSARDDLETARELVASDESFAAEVAALEARVGELDAQLTDMLAPRDPHDA
FT DDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWAVTVLDETTSDLGGYKDATLAIA
FT SKADTPDGVWSRMKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVGQVQIDESD
FT LRIDVFRSSGKGGQGVNTTDSAVRITHLPTGIVVTCQNERSQLQNKTRALQVLAARLQA
FT MAEEQALADASADRASQIRTVDRSERIRTYNFPENRITDHRIGYKSHNLDQVLDGDLDA
FT LFDALSAADKQSRLRQS"
FT misc_feature 73136..73186
FT /note="PS00745 Prokaryotic-type class I peptide chain
FT release factors signature"
FT CDS 73522..74499
FT /transl_table=11
FT /gene="hemK"
FT /locus_tag="Rv1300"
FT /product="PROBABLE HEMK PROTEIN HOMOLOG HEMK"
FT /function="POSSIBLY INVOLVED IN THE OXIDATION OF
FT PROTOPORPHYRINOGEN INTO PROTOPORPHYRIN IX"
FT /EC_number="2.1.1.-"
FT /note="Rv1300, (MTCY373.20), len: 325 aa. Probable hemK
FT protein homolog (EC 2.1.1.-), homology suggests translation
FT may start at aa 22, highly similar to many e.g.
FT HEMK_MYCLE|P45832 Mycobacterium leprae (288 aa), FASTA
FT scores: opt: 936, E(): 0, (76.7% identity in 189 aa
FT overlap). BELONGS TO THE HEMK FAMILY OF MODIFICATION
FT METHYLASES."
FT /db_xref="GOA:Q10602"
FT /db_xref="InterPro:IPR002052"
FT /db_xref="InterPro:IPR004556"
FT /db_xref="InterPro:IPR007848"
FT /db_xref="UniProtKB/Swiss-Prot:Q10602"
FT /protein_id="CAA97733.1"
FT /translation="MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARC
FT DAEQLAAHLAGTDRGRLPLFEPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLH
FT VGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALAQHRANLGLKARIIG
FT IDDSDCALDYARRNAAGTPVELVRADVTTPRLLPELDGQVDLMVSNPPYIPDAAVLEPE
FT VAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLF
FT VDVQARKDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR"
FT repeat_region 73542..73584
FT /note="43 bp Mycobacterial Interspersed Repetitive Unit,
FT Class III"
FT repeat_region 74410..74461
FT /note="52 bp Mycobacterial Interspersed Repetitive Unit,
FT Class III"
FT repeat_region 74462..74514
FT /note="53 bp Mycobacterial Interspersed Repetitive Unit,
FT Class II"
FT CDS 74515..75168
FT /transl_table=11
FT /locus_tag="Rv1301"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1301, (MTCY373.21), len: 217 aa. Conserved
FT hypothetical protein, highly similar to YRFE_MYCLE|P45831
FT hypothetical 22.7 kDa protein in rfe-hemk intergenic
FT region, (220 aa), FASTA scores: opt: 1168, E(): 0, (82.8%
FT identity in 215 aa overlap). Contains PS01147 Hypothetical
FT SUA5/yciO/yrdC family signature. BELONGS TO THE
FT SUA5/YRDC/YCIO/YWLC FAMILY."
FT /db_xref="InterPro:IPR004388"
FT /db_xref="InterPro:IPR006070"
FT /db_xref="InterPro:IPR017945"
FT /db_xref="UniProtKB/Swiss-Prot:Q10618"
FT /protein_id="CAA97734.1"
FT /translation="MTETFDCADPEQRSRGIVSAVGAIKAGQLVVMPTDTVYGIGADAF
FT DSSAVAALLSAKGRGRDMPVGVLVGSWHTIEGLVYSMPDGARELIRAFWPGALSLVVVQ
FT APSLQWDLGDAHGTVMLRMPLHPVAIELLREVGPMAVSSANISGHPPPVDAEQARSQLG
FT DHVAVYLDAGPSEQQAGSTIVDLTGATPRVLRPGPVSTERIAEVLGVDAASLFG"
FT misc_feature 74599..74637
FT /note="PS01147 Hypothetical SUA5/yciO/yrdC family
FT signature"
FT CDS 75252..76466
FT /transl_table=11
FT /gene="rfe"
FT /locus_tag="Rv1302"
FT /standard_name="wecA"
FT /product="PROBABLE UNDECAPAPRENYL-PHOSPHATE
FT ALPHA-N-ACETYLGLUCOSAMINYLTRANSFERASE RFE (UDP-GlcNAc
FT TRANSFERASE)"
FT /function="THOUGHT TO BE INVOLVED IN AG BIOSYNTHESIS. MAY
FT BE THE TUNICAMYCIN SENSITIVE TRANSFERASE THAT CATALYZES THE
FT SYNTHESIS OF GLCNAC-PYROPHOSPHORYLUNDECAPRENOL (LIPID I),
FT THE FIRST LIPID-LINKED INTERMEDIATE INVOLVED IN ECA
FT SYNTHESIS."
FT /EC_number="2.4.1.-"
FT /note="Rv1302, (MTCY373.22), len: 404 aa. Probable rfe
FT (alternate gene name: wecA), undecaprenyl-phosphate
FT alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-) (see
FT citation below), equivalent to RFE_MYCLE|P45830
FT Mycobacterium leprae (398 aa), FASTA scores, opt: 2285,
FT E(): 0, (89.2% identity in 398 aa overlap)."
FT /db_xref="GOA:Q10606"
FT /db_xref="InterPro:IPR000715"
FT /db_xref="InterPro:IPR018481"
FT /db_xref="UniProtKB/Swiss-Prot:Q10606"
FT /protein_id="CAA97735.1"
FT /translation="MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITY
FT FATGPVRMLASRLGAVAYPRERDVHVTPTPRMGGLAMFLGIVGAVFLASQLPALTRGFV
FT YSTGMPAVLVAGAVIMGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPVGG
FT VGTIVLDQASSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHG
FT GDVLYYPPAVISVVLAGACLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQ
FT NAYGARDVFALLSPFLLVVAVMFVPMLDLLLAIVRRTRAGRSAFSPDKMHLHHRLLQIG
FT HSHRRVVLIIYLWVGIVAFGAASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYY
FT DPDLD"
FT CDS 76723..77208
FT /transl_table=11
FT /locus_tag="Rv1303"
FT /product="CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1303, (MTCY373.23), len: 161 aa. Conserved
FT hypothetical transmembrane protein, highly similar to
FT P53431|Y02N_MYCLE hypothetical Mycobacterium leprae protein
FT (153 aa), FASTA score: opt: 636, E():0, (69.8% identity in
FT 149 aa overlap)."
FT /db_xref="GOA:P64801"
FT /db_xref="InterPro:IPR008413"
FT /db_xref="UniProtKB/Swiss-Prot:P64801"
FT /protein_id="CAA97736.1"
FT /translation="MTTPAQDAPLVFPSVAFRPVRLFFINVGLAAVAMLVAGVFGHLTV
FT GMFLGLGLLLGLLNALLVRRSAESITAKEHPLKRSMALNSASRLAIITILGLIIAYIFR
FT PAGLGVVFGLAFFQVLLVATTALPVLKKLRTATEEPVATYSSNGQTGGSEGRSASDD"
FT CDS 77201..77953
FT /transl_table=11
FT /gene="atpB"
FT /locus_tag="Rv1304"
FT /product="PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6)"
FT /function="KEY COMPONENT OF THE PROTON CHANNEL; IT MAY PLAY
FT A DIRECT ROLE IN THE TRANSLOCATION OF PROTONS (H+) ACROSS
FT THE MEMBRANE"
FT /EC_number="3.6.3.14"
FT /note="Rv1304, (MTCY373.24), len: 250 aa. Probable atpB,
FT ATP synthase A chain (EC 3.6.3.14), highly similar to
FT ATP6_MYCLE|P45829 Mycobacterium leprae (251 aa), FASTA
FT scores: opt: 1382, E(): 0, (84.0% identity in 250 aa
FT overlap). Contains PS00449 ATP synthase A subunit
FT signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1)
FT - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON
FT CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3),
FT GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN
FT SUBUNITS: A, B AND C. BELONGS TO THE ATPASE A CHAIN
FT FAMILY."
FT /db_xref="GOA:P63654"
FT /db_xref="InterPro:IPR000568"
FT /db_xref="UniProtKB/Swiss-Prot:P63654"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97737.1"
FT /translation="MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAF
FT YLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIGMRIAPFVLPLAVTIFVFILISNWL
FT AVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKLLKG
FT HVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLF
FT VGAIQAFIFALLTILYFSQAMELEEEHH"
FT misc_feature 77744..77773
FT /note="PS00449 ATP synthase a subunit signature"
FT CDS 78002..78247
FT /transl_table=11
FT /gene="atpE"
FT /locus_tag="Rv1305"
FT /product="PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING
FT PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN)"
FT /function="THIS IS ONE OF THE THREE CHAINS OF THE
FT NONENZYMATIC COMPONENT (CF(0) SUBUNIT) OF THE ATPASE
FT COMPLEX."
FT /EC_number="3.6.3.14"
FT /note="Rv1305, (MTCY373.25), len: 81 aa. Probable atpE, ATP
FT synthase C chain (EC 3.6.3.14), highly similar to
FT P45828|ATPL_MYCLE Mycobacterium leprae (92.6% identity in
FT 81 aa overlap). Contains PS00605 ATP synthase C subunit
FT signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1)
FT - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON
FT CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3),
FT GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN
FT SUBUNITS: A, B AND C. BELONGS TO THE ATPASE C CHAIN
FT FAMILY."
FT /db_xref="GOA:P63691"
FT /db_xref="InterPro:IPR000454"
FT /db_xref="InterPro:IPR002379"
FT /db_xref="InterPro:IPR005953"
FT /db_xref="InterPro:IPR020537"
FT /db_xref="UniProtKB/Swiss-Prot:P63691"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97738.1"
FT /translation="MDPTIAAGALIGGGLIMAGGAIGAGIGDGVAGNALISGVARQPEA
FT QGRLFTPFFITVGLVEAAYFINLAFMALFVFATPVK"
FT misc_feature 78119..78184
FT /note="PS00605 ATP synthase c subunit signature"
FT CDS 78278..78793
FT /transl_table=11
FT /gene="atpF"
FT /locus_tag="Rv1306"
FT /product="PROBABLE ATP SYNTHASE B CHAIN ATPF"
FT /function="THIS IS ONE OF THE THREE CHAINS OF THE
FT NONENZYMATIC COMPONENT (CF(0) SUBUNIT) OF THE ATPASE
FT COMPLEX."
FT /EC_number="3.6.3.14"
FT /note="Rv1306, (MTCY373.26), len: 171 aa. Probable atpF,
FT ATP synthase B chain (EC 3.6.3.14), highly similar to
FT ATPF_MYCLE P45827 (170 aa), FASTA scores, opt: 802, E(): 0,
FT (79.5% identity in 171 aa overlap). SUBUNIT: F-TYPE ATPASES
FT HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) -
FT THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS:
FT ALPHA(3), BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0)
FT HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE
FT B CHAIN FAMILY."
FT /db_xref="GOA:P63656"
FT /db_xref="InterPro:IPR002146"
FT /db_xref="UniProtKB/Swiss-Prot:P63656"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97739.1"
FT /translation="MGEVSAIVLAASQAAEEGGESSNFLIPNGTFFVVLAIFLVVLAVI
FT GTFVVPPILKVLRERDAMVAKTLADNKKSDEQFAAAQADYDEAMTEARVQASSLRDNAR
FT ADGRKVIEDARVRAEQQVASTLQTAHEQLKRERDAVELDLRAHVGTMSATLASRILGVD
FT LTASAATR"
FT CDS 78800..80140
FT /transl_table=11
FT /gene="atpH"
FT /locus_tag="Rv1307"
FT /product="PROBABLE ATP SYNTHASE DELTA CHAIN ATPH"
FT /function="THIS PROTEIN SEEMS TO BE PART OF THE STALK THAT
FT LINKS CF(0) TO CF(1). IT EITHER TRANSMITS CONFORMATIONAL
FT CHANGES FROM CF(0) INTO CF(1) OR IS IMPLICATED IN PROTON
FT CONDUCTION [CATALYTIC ACTIVITY : ATP + H(2)O + H(+)(IN) =
FT ADP + PHOSPHATE + H(+)(OUT)]"
FT /EC_number="3.6.3.14"
FT /note="Rv1307, (MTCY373.27), len: 446 aa. Probable atpH,
FT ATP synthase delta chain (EC 3.6.3.14). This protein is
FT much longer than that of other bacterial delta chains, the
FT C-terminal region is homologous to delta chains while the
FT N-terminal region is similar to B/B' subunits e.g.
FT ATPD_STRLI|P50008 ATP synthase delta chain from
FT Streptomyces lividans (273 aa), FASTA scores: opt: 505,
FT E(): 5.4e-23, (35.0% identity in 277 aa overlap); and
FT ATPF_HAEIN|P43720 ATP synthase B chain (EC 3.6.1.34) from
FT Haemophilus influenzae (156 aa), FASTA scores: opt: 216,
FT E(): 1.2e-06, (26.1% identity in 153 aa overlap). SUBUNIT:
FT F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC
FT CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS
FT FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1),
FT EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C.
FT BELONGS TO THE ATPASE DELTA CHAIN FAMILY."
FT /db_xref="GOA:P0A500"
FT /db_xref="InterPro:IPR000711"
FT /db_xref="InterPro:IPR002146"
FT /db_xref="UniProtKB/Swiss-Prot:P0A500"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97740.1"
FT /translation="MSTFIGQLFGFAVIVYLVWRFIVPLVGRLMSARQDTVRQQLADAA
FT AAADRLAEASQAHTKALEDAKSEAHRVVEEARTDAERIAEQLEAQADVEAERIKMQGAR
FT QVDLIRAQLTRQLRLELGHESVRQARELVRNHVADQAQQSATVDRFLDQLDAMAPATAD
FT VDYPLLAKMRSASRRALTSLVDWFGTMAQDLDHQGLTTLAGELVSVARLLDREAVVTRY
FT LTVPAEDATPRIRLIERLVSGKVGAPTLEVLRTAVSKRWSANSDLIDAIEHVSRQALLE
FT LAERAGQVDEVEDQLFRFSRILDVQPRLAILLGDCAVPAEGRVRLLRKVLERADSTVNP
FT VVVALLSHTVELLRGQAVEEAVLFLAEVAVARRGEIVAQVGAAAELSDAQRTRLTEVLS
FT RIYGHPVTVQLHIDAALLGGLSIAVGDEVIDGTLSSRLAAAEARLPD"
FT CDS 80185..81834
FT /transl_table=11
FT /gene="atpA"
FT /locus_tag="Rv1308"
FT /product="PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA"
FT /function="PRODUCES ATP FROM ADP IN THE PRESENCE OF A
FT PROTON GRADIENT ACROSS THE MEMBRANE. THE ALPHA CHAIN IS A
FT REGULATORY SUBUNIT [CATALYTIC ACTIVITY:ATP + H(2)O +
FT H(+)(IN) = ADP + PHOSPHATE + H(+)(OUT)]"
FT /EC_number="3.6.3.14"
FT /note="Rv1308, (MTCY373.28), len: 549 aa. Probable atpA,
FT ATP synthase alpha chain (EC 3.6.3.14), highly similar to
FT ATPA_MYCLE|P45825 from Mycobacterium leprae (558 aa), FASTA
FT scores: opt: 3233, E(): 0, (90.3% identity in 547 aa
FT overlap). Contains PS00017 ATP/GTP-binding site motif A,
FT PS00152 ATP synthase alpha and beta subunits signature.
FT SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE
FT CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL.
FT CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1),
FT DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B
FT AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY."
FT /db_xref="GOA:P63673"
FT /db_xref="InterPro:IPR000194"
FT /db_xref="InterPro:IPR000793"
FT /db_xref="InterPro:IPR004100"
FT /db_xref="InterPro:IPR005294"
FT /db_xref="InterPro:IPR017458"
FT /db_xref="InterPro:IPR018118"
FT /db_xref="InterPro:IPR020003"
FT /db_xref="UniProtKB/Swiss-Prot:P63673"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97741.1"
FT /translation="MAELTIPADDIQSAIEEYVSSFTADTSREEVGTVVDAGDGIAHVE
FT GLPSVMTQELLEFPGGILGVALNLDEHSVGAVILGDFENIEEGQQVKRTGEVLSVPVGD
FT GFLGRVVNPLGQPIDGRGDVDSDTRRALELQAPSVVHRQGVKEPLQTGIKAIDAMTPIG
FT RGQRQLIIGDRKTGKTAVCVDTILNQRQNWESGDPKKQVRCVYVAIGQKGTTIAAVRRT
FT LEEGGAMDYTTIVAAAASESAGFKWLAPYTGSAIAQHWMYEGKHVLIIFDDLTKQAEAY
FT RAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDDLGGGSLTGLPIIETKANDISAY
FT IPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQ
FT YRELEAFAAFASDLDAASKAQLERGARLVELLKQPQSQPMPVEEQVVSIFLGTGGHLDS
FT VPVEDVRRFETELLDHMRASEEEILTEIRDSQKLTEEAADKLTEVIKNFKKGFAATGGG
FT SVVPDEHVEALDEDKLAKEAVKVKKPAPKKKK"
FT misc_feature 80698..80721
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature 81280..81309
FT /note="PS00152 ATP synthase alpha and beta subunits
FT signature"
FT CDS 81841..82758
FT /transl_table=11
FT /gene="atpG"
FT /locus_tag="Rv1309"
FT /product="PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG"
FT /function="PRODUCES ATP FROM ADP IN THE PRESENCE OF A
FT PROTON GRADIENT ACROSS THE MEMBRANE. THE GAMMA CHAIN IS
FT BELIEVED TO BE IMPORTANT IN REGULATING ATPASE ACTIVITY AND
FT THE FLOW OF PROTONS THROUGH THE CF(0) COMPLEX."
FT /EC_number="3.6.3.14"
FT /note="Rv1309, (MTCY373.29), len: 305 aa. Probable atpG,
FT ATP synthase gamma chain (EC 3.6.3.14), highly similar to
FT ATPG_MYCLE|P45824 ATP synthase gamma chain from
FT Mycobacterium leprae (298 aa), FASTA scores: opt: 1579,
FT E():0, (83.9% identity in 305 aa overlap). Contains PS00153
FT ATP synthase gamma subunit signature. SUBUNIT: F-TYPE
FT ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND
FT CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE
FT SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1),
FT EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C.
FT BELONGS TO THE ATPASE GAMMA CHAIN FAMILY."
FT /db_xref="GOA:P63671"
FT /db_xref="InterPro:IPR000131"
FT /db_xref="UniProtKB/Swiss-Prot:P63671"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97742.1"
FT /translation="MAATLRELRGRIRSAGSIKKITKAQELIATSRIARAQARLESARP
FT YAFEITRMLTTLAAEAALDHPLLVERPEPKRAGVLVVSSDRGLCGAYNANIFRRSEELF
FT SLLREAGKQPVLYVVGRKAQNYYSFRNWNITESWMGFSEQPTYENAAEIASTLVDAFLL
FT GTDNGEDQRSDSGEGVDELHIVYTEFKSMLSQSAEAHRIAPMVVEYVEEDIGPRTLYSF
FT EPDATMLFESLLPRYLTTRVYAALLESAASELASRQRAMKSATDNADDLIKALTLMANR
FT ERQAQITQEISEIVGGANALAEAR"
FT misc_feature 82699..82740
FT /note="PS00153 ATP synthase gamma subunit signature"
FT CDS 82798..84258
FT /transl_table=11
FT /gene="atpD"
FT /locus_tag="Rv1310"
FT /product="PROBABLE ATP SYNTHASE BETA CHAIN ATPD"
FT /function="PRODUCES ATP FROM ADP IN THE PRESENCE OF A
FT PROTON GRADIENT ACROSS THE MEMBRANE. THE BETA CHAIN IS THE
FT CATALYTIC SUBUNIT [CATALYTIC ACTIVITY : ATP + H(2)O +
FT H(+)(IN) = ADP + PHOSPHATE + H(+)(OUT)]"
FT /EC_number="3.6.3.14"
FT /note="Rv1310, (MTCY373.30), len: 486 aa. Probable atpD,
FT ATP synthase beta chain (EC 3.6.3.14), highly similar to
FT ATPB_MYCLE|P45823 Mycobacterium leprae (485 aa), FASTA
FT score: opt: 2916, E(): 0, (92.6% identity in 484 aa
FT overlap). Contains PS00017 ATP/GTP-binding site motif A,
FT PS00152 ATP synthase alpha and beta subunits signature.
FT SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE
FT CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL.
FT CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1),
FT DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B
FT AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY."
FT /db_xref="GOA:P63677"
FT /db_xref="InterPro:IPR000194"
FT /db_xref="InterPro:IPR000793"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR004100"
FT /db_xref="InterPro:IPR005722"
FT /db_xref="InterPro:IPR018118"
FT /db_xref="InterPro:IPR020003"
FT /db_xref="UniProtKB/Swiss-Prot:P63677"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97743.1"
FT /translation="MTTTAEKTDRPGKPGSSDTSGRVVRVTGPVVDVEFPRGSIPELFN
FT ALHAEITFESLAKTLTLEVAQHLGDNLVRTISLQPTDGLVRGVEVIDTGRSISVPVGEG
FT VKGHVFNALGDCLDEPGYGEKFEHWSIHRKPPAFEELEPRTEMLETGLKVVDLLTPYVR
FT GGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELAEANVLK
FT DTALVFGQMDEPPGTRMRVALSALTMAEWFRDEQGQDVLLFIDNIFRFTQAGSEVSTLL
FT GRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDA
FT TTELSRAVFSKGIFPAVDPLASSSTILDPSVVGDEHYRVAQEVIRILQRYKDLQDIIAI
FT LGIDELSEEDKQLVNRARRIERFLSQNMMAAEQFTGQPGSTVPVKETIEAFDRLCKGDF
FT DHVPEQAFFLIGGLDDLAKKAESLGAKL"
FT misc_feature 83308..83331
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature 83860..83889
FT /note="PS00152 ATP synthase alpha and beta subunits
FT signature"
FT CDS 84272..84637
FT /transl_table=11
FT /gene="atpC"
FT /locus_tag="Rv1311"
FT /product="PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC"
FT /function="PRODUCES ATP FROM ADP IN THE PRESENCE OF A
FT PROTON GRADIENT ACROSS THE MEMBRANE [CATALYTIC ACTIVITY :
FT ATP + H(2)O + H(+)(IN) = ADP + PHOSPHATE + H(+)(OUT)]"
FT /EC_number="3.6.3.14"
FT /note="Rv1311, (MTCY373.31), len: 121 aa. Probable atpC,
FT ATP synthase epsilon chain (EC 3.6.3.14), highly similar to
FT ATPE_MYCLE|P45822 Mycobacterium leprae (124 aa), FASTA
FT scores: opt: 682, E(): 5.4e-40, (87.6% identity in 121 aa
FT overlap). SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1)
FT - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON
FT CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3),
FT GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN
FT SUBUNITS: A, B AND C. BELONGS TO THE ATPASE EPSILON CHAIN
FT FAMILY."
FT /db_xref="GOA:P63662"
FT /db_xref="InterPro:IPR001469"
FT /db_xref="InterPro:IPR020546"
FT /db_xref="InterPro:IPR020547"
FT /db_xref="UniProtKB/Swiss-Prot:P63662"
FT /protein_id="CAA97744.1"
FT /translation="MAELNVEIVAVDRNIWSGTAKFLFTRTTVGEIGILPRHIPLVAQL
FT VDDAMVRVEREGEKDLRIAVDGGFLSVTEEGVSILAESAEFESEIDEAAAKQDSESDDP
FT RIAARGRARLRAVGAID"
FT CDS 84645..85088
FT /transl_table=11
FT /locus_tag="Rv1312"
FT /product="CONSERVED HYPOTHETICAL SECRETED PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1312, (MTCY373.32), len: 147 aa. Conserved
FT hypothetical secreted protein with potential N-terminal
FT signal sequence. Highly similar to P53432|Y02W_MYCLE
FT hypothetical Mycobacterium leprae protein (147 aa), FASTA
FT score: opt: 884, E(): 0, (88.4% identity in 147 aa
FT overlap). N-terminus hydrophobic."
FT /db_xref="GOA:Q10620"
FT /db_xref="InterPro:IPR019675"
FT /db_xref="UniProtKB/Swiss-Prot:Q10620"
FT /protein_id="CAA97745.1"
FT /translation="MSAPMIGMVVLVVVLGLAVLALSYRLWKLRQGGTAGIMRDIPAVG
FT GHGWRHGVIRYRGGEAAFYRLSSLRLWPDRRLSRRGVEIISRRAPRGDEFDIMTDEIVV
FT VELCDSTQDRRVGYEIALDRGALTAFLSWLESRPSPRARRRSM"
FT repeat_region 85100..85118
FT /note="19 bp inverted repeat, GCAGACGCAAAAGCCCCCA, at the
FT left end of IS1557"
FT repeat_region complement(85100..86608)
FT /mobile_element="insertion sequence:IS1557-2"
FT /note="IS1557-2, len: 1509 bp. Insertion sequence IS1557."
FT CDS complement(85128..86462)
FT /transl_table=11
FT /locus_tag="Rv1313c"
FT /product="POSSIBLE TRANSPOSASE"
FT /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE
FT INSERTION ELEMENT IS1557."
FT /note="Rv1313c, (MTCY373.33c), len: 444 aa. Possible IS1557
FT transposase, similar to several transposases e.g.
FT U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium
FT DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3%
FT identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase
FT for insertion sequence element IS1001 from Bordetella
FT parapertussis (406 aa), FASTA scores: opt: 254, E():
FT 3.3e-10, (24.9% identity in 402 aa overlap). Also similar
FT to putative Mycobacterium tuberculosis transposases, Rv3798
FT and Rv0741."
FT /db_xref="GOA:Q10621"
FT /db_xref="InterPro:IPR002560"
FT /db_xref="UniProtKB/Swiss-Prot:Q10621"
FT /protein_id="CAA97746.1"
FT /translation="MRNVRLFRALLGVDKRTVIEDIEFEEDDAGDGARVIARVRPRSAV
FT LRRCGRCGRKASWYDRGAGLRQWRSLDWGTVEVFLEAEAPRVNCPTHGPTVVAVPWARH
FT HAGHTYAFDDTVAWLAVACSKTAVCELMRIAWRTVGAIVARVWADTEKRIDRFANLRRI
FT GIDEISYKRHHRYLTVVVDHDSGRLVWAAPGHDKATLGLFFDALGAERAAQITHVSADA
FT ADWIADVVTERCPDAIQCADPFHVVAWATEALDVERRRAWNDARAIARTEPKWGRGRPG
FT KNAAPRPGRERARRLKGARYALWKNPEDLTERQSAKLAWIAKTDPRLYRAYLLKESLRH
FT VFSVKGEEGKQALDRWISWAQRCRIPVFVELAARIKRHRVAIDAALDHGLSQGLIESTN
FT TKIRLLTRIAFGFRSPQALIALAMLTLAGHRPTLPGRHNHPQISQ"
FT repeat_region complement(86590..86608)
FT /note="19 bp inverted repeat, GCAGACGCGAAAGCCCCCA, at the
FT right end of IS1557. Single base difference at 3-end."
FT CDS complement(86628..87209)
FT /transl_table=11
FT /locus_tag="Rv1314c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1314c, (MTCY373.34c), len: 193 aa. Conserved
FT hypothetical protein, highly similar to P53523|Y02Y_MYCLE
FT hypothetical Mycobacterium leprae protein (191 aa), FASTA
FT score: opt:1019, E(): 0, (81.2% identity in 191 aa
FT overlap). Some similarity with YDHW_CITFR|P45515
FT hypothetical 19.8 kDa protein in dhar-dhat intergenic
FT region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13,
FT (37.6% identity in 178 aa overlap). Also similar to
FT hypothetical protein AE002007|AE002007_3 Deinococcus
FT radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19,
FT (42.4% identity in 172 aa overlap)."
FT /db_xref="GOA:P64803"
FT /db_xref="InterPro:IPR002779"
FT /db_xref="InterPro:IPR016030"
FT /db_xref="InterPro:IPR017858"
FT /db_xref="PDB:2G2D"
FT /db_xref="UniProtKB/Swiss-Prot:P64803"
FT /protein_id="CAA97747.1"
FT /translation="MAVHLTRIYTRTGDDGTTGLSDMSRVAKTDARLVAYADCDEANAA
FT IGAALALGHPDTQITDVLRQIQNDLFDAGADLSTPIVENPKHPPLRIAQSYIDRLEGWC
FT DAYNAGLPALKSFVLPGGSPLSALLHVARTVVRRAERSAWAAVDAHPEGVSVLPAKYLN
FT RLSDLLFILSRVANPDGDVLWRPGGDRTAS"
FT CDS 87278..88534
FT /transl_table=11
FT /gene="murA"
FT /locus_tag="Rv1315"
FT /product="PROBABLE UDP-N-ACETYLGLUCOSAMINE
FT 1-CARBOXYVINYLTRANSFERASE MURA"
FT /function="INVOLVED IN CELL WALL FORMATION; PEPTIDOGLYCAN
FT BIOSYNTHESIS. ADDS ENOLPYRUVYL TO UDP-N-ACETYLGLUCOSAMINE
FT [CATALYTIC ACTIVITY: PHOSPHOENOLPYRUVATE + UDP-N-ACETYL-D-
FT GLUCOSAMINE = PHOSPHATE +
FT UDP-N-ACETYL-3-O-(1-CARBOXYVINYL)-D-GLUCOSAMINE]"
FT /EC_number="2.5.1.7"
FT /note="Rv1315, (MTCY373.35-MTCY149.01), len: 418 aa.
FT Probable murA, UDP-N-acetylglucosamine
FT 1-carboxyvinyltransferase (EC 2.5.1.7) (see Belanger &
FT Inamine 2000), highly similar to many e.g.
FT MURA_MYCLE|P45821 (418 aa), FASTA scores: opt: 2495, E():
FT 0, (96.2% identity in 396 aa overlap). BELONGS TO THE EPSP
FT SYNTHASE FAMILY. MURA SUBFAMILY."
FT /db_xref="GOA:P0A5L2"
FT /db_xref="InterPro:IPR001986"
FT /db_xref="InterPro:IPR005750"
FT /db_xref="InterPro:IPR013792"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5L2"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA97748.1"
FT /translation="MAERFVVTGGNRLSGEVAVGGAKNSVLKLMAATLLAEGTSTITNC
FT PDILDVPLMAEVLRGLGATVELDGDVARITAPDEPKYDADFAAVRQFRASVCVLGPLVG
FT RCKRARVALPGGDAIGSRPLDMHQAGLRQLGAHCNIEHGCVVARAETLRGAEIQLEFPS
FT VGATENILMAAVVAEGVTTIHNAAREPDVVDLCTMLNQMGAQVEGAGSPTMTITGVPRL
FT HPTEHRVIGDRIVAATWGIAAAMTRGDISVAGVDPAHLQLVLHKLHDAGATVTQTDASF
FT RVTQYERPKAVNVATLPFPGFPTDLQPMAIALASIADGTSMITENVFEARFRFVEEMIR
FT LGADARTDGHHAVVRGLPQLSSAPVWCSDIRAGAGLVLAGLVADGDTEVHDVFHIDRGY
FT PLFVENLVSLGAEIERVCC"
FT rRNA 88803..90339
FT /gene="rrs"
FT /product="ribosomal RNA 16S"
FT /note="rrs (alternate gene name: rrnS), len: 1537 nt. 16s
FT rRNA gene."
FT rRNA 90615..93752
FT /gene="rrl"
FT /product="ribosomal RNA 23S"
FT /note="rrl, len: 3138 nt. 23S rRNA gene (approximate
FT coordinates)."
FT rRNA 93856..93970
FT /gene="rrf"
FT /product="ribosomal RNA 5S"
FT /note="rrf, len: 115 nt. 5S rRNA gene. Identical to
FT Em_ba:MT5SRR, D10035 M.tuberculosis 5S rRNA."
FT CDS complement(94091..94588)
FT /transl_table=11
FT /gene="ogt"
FT /locus_tag="Rv1316c"
FT /product="PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE
FT METHYLTRANSFERASE OGT (6-O-methylguanine-DNA
FT methyltransferase)
FT (O-6-methylguanine-DNA-alkyltransferase)"
FT /function="REPAIR OF ALKYLATED GUANINE IN DNA BY
FT STOICHIOMETRICALLY TRANSFERRING THE ALKYL GROUP AT THE O-6
FT POSITION TO A CYSTEINE RESIDUE IN THE ENZYME. THIS IS A
FT SUICIDE REACTION: THE ENZYME IS IRREVERSIBLY INACTIVATED
FT [CATALYTIC ACTIVITY : DNA (CONTAINING 6-O-METHYLGUANINE) +
FT [PROTEIN]-L-CYSTEINE = DNA (WITHOUT 6-O-METHYLGUANINE) +
FT PROTEIN S-METHYL-L-CYSTEINE.]"
FT /EC_number="2.1.1.63"
FT /note="Rv1316c, (MTCY130.01c), len: 165 aa. Probable ogt,
FT methylated-dna--protein-cysteine methytransferase (EC
FT 2.1.1.63) (see citation below), similar to many e.g.
FT OGT_HAEIN|P44687 Haemophilus influenzae (190 aa), FASTA
FT scores: opt: 405, E(): 6.5e-20, (41.9% identity in 155 aa
FT overlap). Contains PS00374 Methylated-DNA--protein-cysteine
FT methyltransferase active site."
FT /db_xref="GOA:P0A696"
FT /db_xref="InterPro:IPR001497"
FT /db_xref="InterPro:IPR008332"
FT /db_xref="InterPro:IPR011991"
FT /db_xref="InterPro:IPR014048"
FT /db_xref="UniProtKB/Swiss-Prot:P0A696"
FT /protein_id="CAA98103.1"
FT /translation="MIHYRTIDSPIGPLTLAGHGSVLTNLRMLEQTYEPSRTHWTPDPG
FT AFSGAVDQLNAYFAGELTEFDVELDLRGTDFQQRVWKALLTIPYGETRSYGEIADQIGA
FT PGAARAVGLANGHNPIAIIVPCHRVIGASGKLTGYGGGINRKRALLELEKSRAPADLTL
FT FD"
FT misc_feature complement(94199..94219)
FT /note="PS00374 Methylated-DNA--protein-cysteine
FT methyltransferase active site"
FT CDS complement(94585..96075)
FT /transl_table=11
FT /gene="alkA"
FT /locus_tag="Rv1317c"
FT /standard_name="ada"
FT /product="PROBABLE ADA REGULATORY PROTEIN ALKA (Regulatory
FT protein of adaptative response)
FT (Methylated-DNA--protein-cysteine methyltransferase)
FT (O-6-methylguanine-DNA alkyltransferase)
FT (O-6-methylguanine-DNA methyltransferase) (3-methyladenine
FT DNA glycosylase II)"
FT /function="INVOLVED IN DAMAGE REVERSAL AND IN BASE EXCISION
FT REPAIR. THE METHYLATED ADA PROTEIN ACTS AS A POSITIVE
FT REGULATOR OF ITS OWN SYNTHESIS, AS WELL AS THAT OF OTHER
FT PROTEINS. THE TRANSCRIPTION-ACTIVATING FUNCTION OF THE ADA
FT PROTEIN RESIDES IN ITS N-TERMINUS. REPAIR OF ALKYLATED
FT GUANINE IN DNA BY STOICHIOMETRICALLY TRANSFERRING THE ALKYL
FT GROUP AT THE O-6 POSITION TO A CYSTEINE RESIDUE IN THE
FT ENZYME. THIS IS A SUICIDE REACTION: THE ENZYME IS
FT IRREVERSIBLY INACTIVATED. CAN ALSO REPAIR O-4-METHYLTHYMINE
FT [CATALYTIC ACTIVITY: DNA (CONTAINING 6-O-METHYLGUANINE) +
FT [PROTEIN]-L-CYSTEINE = DNA (WITHOUT 6-O-METHYLGUANINE) +
FT PROTEIN S-METHYL-L-CYSTEINE]"
FT /EC_number="2.1.1.63"
FT /note="Rv1317c, (MTCY130.02c), len: 496 aa. Probable alkA
FT (alternate gene name: ada), regulatory protein (EC
FT 2.1.1.63) (see citation below), similar to
FT 3MG2_ECOLI|P04395 dna-3-methyladenine glycosidase II from
FT Escherichia coli (282 aa), FASTA scores, opt: 437, E():
FT 8.6e-22, (32.8% identity in 293 aa overlap), also similar
FT to other ada proteins e.g. ADA_SALTY|P26189 Salmonella
FT typhimurium (352 aa), FASTA scores: E(): 5.3e-08, (35.9%
FT identity in 156 aa overlap). Contains PS00041 Bacterial
FT regulatory proteins, araC family signature."
FT /db_xref="GOA:Q10630"
FT /db_xref="InterPro:IPR000005"
FT /db_xref="InterPro:IPR003265"
FT /db_xref="InterPro:IPR003583"
FT /db_xref="InterPro:IPR004026"
FT /db_xref="InterPro:IPR009057"
FT /db_xref="InterPro:IPR010316"
FT /db_xref="InterPro:IPR011257"
FT /db_xref="InterPro:IPR012287"
FT /db_xref="InterPro:IPR012294"
FT /db_xref="InterPro:IPR018060"
FT /db_xref="InterPro:IPR018062"
FT /db_xref="UniProtKB/Swiss-Prot:Q10630"
FT /protein_id="CAA98104.1"
FT /translation="MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFA
FT RNVRFLPTAAAAQGEGFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDRDGVS
FT GLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNLPFGDVAFAAGFSS
FT IRQFNDTVRLACDGTPTALRARAAARFESATASAGTVSLRLPVRAPFAFEGVFGHLAAT
FT AVPGCEEVRDGAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLD
FT LDADPEAIVEALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAG
FT RLVAAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLVL
FT DAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLGLRLAAKKLGLPAQRR
FT ALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQEKIA"
FT misc_feature complement(95539..95667)
FT /note="PS00041 Bacterial regulatory proteins, araC family
FT signature"
FT CDS complement(96156..97781)
FT /transl_table=11
FT /locus_tag="Rv1318c"
FT /product="POSSIBLE ADENYLATE CYCLASE (ATP
FT PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)"
FT /function="THOUGHT TO PLAY AN ESSENTIAL ROLES IN REGULATION
FT OF CELLULAR METABOLISM BY CATALYSING THE SYNTHESIS OF A
FT SECOND MESSENGER, CAMP [CATALYTIC ACTIVITY: ATP =
FT 3',5'-CYCLIC AMP + PYROPHOSPHATE]."
FT /EC_number="4.6.1.1"
FT /note="Rv1318c, (MTCY130.03c), len: 541 aa. Possible
FT adenylate cyclase (EC 4.6.1.1). Some similarity at the
FT c-terminus to CYAA_RHIME|P19485 adenylate cyclase from
FT Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E():
FT 2.5e-11, (28.8% identity in 184 aa overlap); similar to
FT other mycbacterium tuberculosis putative adenylate cyclases
FT e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505,
FT E(): 0, (71.0% identity in 534 aa overlap), also similar to
FT Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423, E():
FT 0, (68.7% identity in 534 aa overlap). N-terminus is
FT hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY."
FT /db_xref="GOA:P63527"
FT /db_xref="InterPro:IPR001054"
FT /db_xref="InterPro:IPR003660"
FT /db_xref="UniProtKB/Swiss-Prot:P63527"
FT /protein_id="CAA98105.1"
FT /translation="MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRR
FT RRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALA
FT LGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGL
FT INNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMV
FT VWLLGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTAT
FT PVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGR
FT EVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDR
FT HHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQV
FT IAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGR
FT HVKLRGHDQPVRLAKPVGLTKPRR"
FT CDS complement(97851..99458)
FT /transl_table=11
FT /locus_tag="Rv1319c"
FT /product="POSSIBLE ADENYLATE CYCLASE (ATP
FT PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)"
FT /function="THOUGHT TO PLAY AN ESSENTIAL ROLES IN REGULATION
FT OF CELLULAR METABOLISM BY CATALYSING THE SYNTHESIS OF A
FT SECOND MESSENGER, CAMP [CATALYTIC ACTIVITY: ATP =
FT 3',5'-CYCLIC AMP + PYROPHOSPHATE]."
FT /EC_number="4.6.1.1"
FT /note="Rv1319c, (MTCY130.04c), len: 535 aa. Possible
FT adenylate cyclase (EC 4.6.1.1). Some similarity at the
FT C-terminus to CYAA_RHIME|P19485 adenylate cyclase from
FT Rhizobium meliloti (193 aa), FASTA scores: opt: 254, E():
FT 2.4e-10, (33.3% identity in 144 aa overlap); similar to
FT other mycbacterium tuberculosis putative adenylate cyclases
FT e.g. Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2505,
FT E(): 0, (71.0% identity in 534 aa overlap);
FT Rv1320c|MTCY130.05c (567 aa), FASTA scores: opt: 2354, E():
FT 0, (66.3% identity in 534 aa overlap). N-terminus is
FT hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY."
FT /db_xref="GOA:P0A4Y2"
FT /db_xref="InterPro:IPR001054"
FT /db_xref="InterPro:IPR003660"
FT /db_xref="UniProtKB/Swiss-Prot:P0A4Y2"
FT /protein_id="CAA98106.1"
FT /translation="MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSR
FT RWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALA
FT IGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYG
FT LANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTM
FT TVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTA
FT APVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVG
FT REVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVD
FT RHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQ
FT IVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLG
FT ETVTLRGHEQPTRLAVPT"
FT CDS complement(99471..101174)
FT /transl_table=11
FT /locus_tag="Rv1320c"
FT /product="POSSIBLE ADENYLATE CYCLASE (ATP
FT PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE)"
FT /function="THOUGHT TO PLAY AN ESSENTIAL ROLES IN REGULATION
FT OF CELLULAR METABOLISM BY CATALYSING THE SYNTHESIS OF A
FT SECOND MESSENGER, cAMP. MAY BE INVOLVED IN VIRULENCE
FT [CATALYTIC ACTIVITY: ATP = 3',5'-CYCLIC AMP +
FT PYROPHOSPHATE]."
FT /EC_number="4.6.1.1"
FT /note="Rv1320c, (MTCY130.05c), len: 567 aa. Possible
FT adenylate cyclase (EC 4.6.1.1) (see Rindi et al., 1999).
FT Some similarity at the C-terminus to CYAA_RHIME|P19485
FT adenylate cyclase from Rhizobium meliloti (193 aa), FASTA
FT scores: opt: 277, E(): 2e-12, (34.0% identity in 156 aa
FT overlap); similar to other mycbacterium tuberculosis
FT putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541
FT aa), FASTA scores: opt: 2423, E(): 0, (68.7% identity in
FT 534 aa overlap); Rv1319c|MTCY130.04c (535 aa), FASTA
FT scores: opt: 2354, E(): 0, (66.3% identity in 534 aa
FT overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL
FT CYCLASE CLASS-3 FAMILY."
FT /db_xref="GOA:Q10633"
FT /db_xref="InterPro:IPR001054"
FT /db_xref="InterPro:IPR003660"
FT /db_xref="UniProtKB/Swiss-Prot:Q10633"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA98107.1"
FT /translation="MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRM
FT RRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFI
FT LGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGL
FT ANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTML
FT VWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTAT
FT PVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGR
FT EVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNH
FT HRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQV
FT VAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGE
FT TVTLRGHDQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD"
FT CDS 101236..101916
FT /transl_table=11
FT /locus_tag="Rv1321"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1321, (MTCY130.06), len: 226 aa. Conserved
FT hypothetical protein. Equivalent to P53524|YD21_MYCLE
FT hypothetical protein from Mycobacterium leprae (201 aa),
FT FASTA scores: opt: 1144, E(): 0, (87.6% identity in 193 aa
FT overlap). Some similarity to hypothetical proteins from
FT other organisms e.g. Y225_METJA|Q57678 Methanococcus
FT jannaschii (263 aa), FASTA scores: E(): 6.5e-05, (25.0%
FT identity in 212 aa overlap)."
FT /db_xref="InterPro:IPR002793"
FT /db_xref="UniProtKB/Swiss-Prot:Q10634"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA98085.1"
FT /translation="MSRVRLVIAQCTVDYIGRLTAHLPSARRLLLFKADGSVSVHADDR
FT AYKPLNWMSPPCWLTEESGGQAPVWVVENKAGEQLRITIEGIEHDSSHELGVDPGLVKD
FT GVEAHLQALLAEHIQLLGEGYTLVRREYMTAIGPVDLLCSDERGGSVAVEIKRRGEIDG
FT VEQLTRYLELLNRDSVLAPVKGVFAAQQIKPQARILATDRGIRCLTLDYDTMRGMDSGE
FT YRLF"
FT CDS 101939..102235
FT /transl_table=11
FT /locus_tag="Rv1322"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1322, (MTCY130.07), len: 98 aa. Conserved
FT hypothetical protein."
FT /db_xref="UniProtKB/Swiss-Prot:P64805"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA98086.1"
FT /translation="MARRRKPLHRQRPEPPSWALRRVEAGPDGHEYEVRPVAAARAVKT
FT YRCPGCDHEIRSGTAHVVVWPTDLPQAGVDDRRHWHTPCWANRATRGPTRKWT"
FT CDS complement(102270..102728)
FT /transl_table=11
FT /locus_tag="Rv1322A"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1322A, len: 152 aa. Conserved hypothetical
FT protein, similar to proteins from Mycobacterium leprae and
FT Streptomyces coelicolor e.g. AL583921_2|ML1157 from M.
FT leprae strain TN (155 aa), FASTA scores: opt: 771, E():
FT 5.1e-43, (75.3% identity in 154 aa overlap); and AL137242_2
FT from Streptomyces coelicolor (146 aa), FASTA scores: opt:
FT 404, E(): 2e-19, (43.165% identity in 139 aa overlap)."
FT /db_xref="GOA:Q8VK36"
FT /db_xref="HSSP:1JC5"
FT /db_xref="InterPro:IPR004360"
FT /db_xref="InterPro:IPR017515"
FT /db_xref="UniProtKB/TrEMBL:Q8VK36"
FT /protein_id="CAE55376.1"
FT /translation="MMTTDQVHARHMLATSLVTGLDHVGIAVADLDVAIEWYHDHLGMI
FT LVHEEINDDQGIREALLAVPGSAAQIQLMAPLDESSVIAKFLDKRGPGIQQLACRVSDL
FT DAMCRRLRSQGVRLVYETARRGTANSRINFIHPKDAGGVLIELVEPAP"
FT CDS 102819..103988
FT /transl_table=11
FT /gene="fadA4"
FT /locus_tag="Rv1323"
FT /product="PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA4
FT (ACETOACETYL-CoA THIOLASE)"
FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID
FT DEGRADATION [CATALYTIC ACTIVITY: 2 ACETYL-CoA = CoA +
FT ACETOACETYL-COA]."
FT /EC_number="2.3.1.9"
FT /note="Rv1323, (MTCY130.08), len: 389 aa. Probable fadA4,
FT acetyl-CoA acetyltransferase (EC 2.3.1.9), equivalent to
FT THIL_MYCLE|P46707 possible acetyl-CoA C-acetyltransferase
FT from Mycobacterium leprae (393 aa), FASTA scores: opt:
FT 2218, E(): 0, (87.0% identity in 392 aa overlap). Also
FT highly similar to others e.g. CAB70629.1|AL137242 probable
FT acetoacetyl-CoA thiolase from Streptomyces coelicolor (401
FT aa); T51772 acetyl-CoA C-acetyltransferase (EC 2.3.1.9)
FT [validated] from Alcaligenes latus (392 aa); etc. Some
FT homologies indicate ATA start codon. Contains PS00098
FT Thiolases acyl-enzyme intermediate signature, PS00737
FT Thiolases signature 2, and PS00099 Thiolases active site.
FT BELONGS TO THE THIOLASE FAMILY."
FT /db_xref="GOA:P66926"
FT /db_xref="InterPro:IPR002155"
FT /db_xref="InterPro:IPR016038"
FT /db_xref="InterPro:IPR016039"
FT /db_xref="InterPro:IPR020610"
FT /db_xref="InterPro:IPR020613"
FT /db_xref="InterPro:IPR020615"
FT /db_xref="InterPro:IPR020616"
FT /db_xref="InterPro:IPR020617"
FT /db_xref="UniProtKB/Swiss-Prot:P66926"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA98087.1"
FT /translation="MIVAGARTPIGKLMGSLKDFSASELGAIAIKGALEKANVPASLVE
FT YVIMGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSGIDAIALADQLIRAREFD
FT VVVAGGQESMTKAPHLLMNSRSGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQRNDV
FT DMFTRSEQDEYAAASHQKAAAAWKDGVFADEVIPVNIPQRTGDPLQFTEDEGIRANTTA
FT AALAGLKPAFRGDGTITAGSASQISDGAAAVVVMNQEKAQELGLTWLAEIGAHGVVAGP
FT DSTLQSQPANAINKALDREGISVDQLDVVEINEAFAAVALASIRELGLNPQIVNVNGGA
FT IAVGHPLGMSGTRITLHAALQLARRGSGVGVAALCGAGGQGDALILRAG"
FT misc_feature 103056..103112
FT /note="PS00098 Thiolases acyl-enzyme intermediate
FT signature"
FT misc_feature 103821..103871
FT /note="PS00737 Thiolases signature 2"
FT misc_feature 103926..103967
FT /note="PS00099 Thiolases active site"
FT CDS 104118..105032
FT /transl_table=11
FT /locus_tag="Rv1324"
FT /product="POSSIBLE THIOREDOXIN"
FT /function="THIOREDOXIN PARTICIPATES IN VARIOUS REDOX
FT REACTIONS THROUGH THE REVERSIBLE OXIDATION OF ITS ACTIVE
FT CENTER DITHIOL, TO A DISULFIDE, & CATALYZES
FT DITHIOL-DISULFIDE EXCHANGE REACTIONS"
FT /EC_number="1.-.-.-"
FT /note="Rv1324, (MTCY130.09), len: 304 aa. Possible
FT thioredoxin (EC 1.-.-.-), similar to several e.g.
FT U00014|Q49716 TRXA from Mycobacterium leprae (255 aa),
FT FASTA scores: opt: 1014, E(): 0, (69.7% identity in 228 aa
FT overlap); THIO_RHOSH|P08058 TrxA from Rhodobacter
FT sphaeroides (105 aa), FASTA scores: opt 196, E(): 1.9e-06,
FT (33.0% identity in 103 aa overlap). Contains PS00339
FT Aminoacyl-transfer RNA synthetases class-II signature 2."
FT /db_xref="GOA:P64807"
FT /db_xref="InterPro:IPR012335"
FT /db_xref="InterPro:IPR012336"
FT /db_xref="InterPro:IPR013766"
FT /db_xref="InterPro:IPR015467"
FT /db_xref="InterPro:IPR017936"
FT /db_xref="UniProtKB/Swiss-Prot:P64807"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA98088.1"
FT /translation="MTRPRPPLGPAMAGAVDLSGIKQRAQQNAAASTDADRALSTPSGV
FT TEITEANFEDEVIVRSDEVPVVVLLWSPRSEVCVDLLDTLSGLAAAAKGKWSLASVNVD
FT VAPRVAQIFGVQAVPTVVALAAGQPISSFQGLQPADQLSRWVDSLLSATAGKLKGAASS
FT EESTEVDPAVAQARQQLEDGDFVAARKSYQAILDANPGSVEAKAAIRQIEFLIRATAQR
FT PDAVSVADSLSDDIDAAFAAADVQVLNQDVSAAFERLIALVRRTSGEERTRVRTRLIEL
FT FELFDPADPEVVAGRRNLANALY"
FT misc_feature 104874..104903
FT /note="PS00339 Aminoacyl-transfer RNA synthetases class-II
FT signature 2"
FT CDS complement(105111..106922)
FT /transl_table=11
FT /gene="PE_PGRS24"
FT /locus_tag="Rv1325c"
FT /product="PE-PGRS FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1325c, (MTCY130.10c), len: 603 aa. Member of the
FT Mycobacterium tuberculosis PE family, PGRS subfamily of
FT ala-, gly-rich proteins (see Brennan & Delogu 2002),
FT similar to many e.g. YQ04_MYCTU|P71933 hypothetical 63.1
FT kDa glycine-rich protein (778 aa), FASTA scores: E(): 0,
FT (52.3% identity in 724 aa overlap)."
FT /db_xref="InterPro:IPR000084"
FT /db_xref="UniProtKB/Swiss-Prot:Q10637"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55377.1"
FT /translation="MSFVIAAPETLVRAASDLANIGSTLGAANAAALGPTTELLAAGAD
FT EVSAAIASLFAAHGQAYQAVSAQMSAFHAQFVQTFTAGAGAYASAEAAAAAPLEGLLNI
FT VNTPTQLLLGRPLIGNGANGAPGTGQAGGAGGLLYGNGGAGGSGAPGQAGGPGGAAGLF
FT GNGGAGGAGGDGPGNGAAGGAGGAGGLLFGSGGAGGPGGVGNTGTGGLGGDGGAAGLFG
FT AGGIGGAGGPGFNGGAGGAGGRSGLFEVLAAGGAGGTGGLSVNGGTGGTGGTGGGGGLF
FT SNGGAGGAGGFGVSGSAGGNGGTGGDGGIFTGNGGTGGTGGTGTGNQLVGGEGGAGGAG
FT GNAGILFGAGGIGGTGGTGLGAPDPGGTGGKGGVGGIGGAGALFGPGGAGGTGGFGASS
FT ADQMAGGIGGSGGSGGAAKLIGDGGAGGTGGDSVRGAAGSGGTGGTGGLIGDGGAGGAG
FT GTGIEFGSVGGAGGAGGNAAGLSGAGGAGGAGGFGETAGDGGAGGNAGLLNGDGGAGGA
FT GGLGIAGDGGNGGKGGKAGMVGNGGDGGAGGASVVANGGVGGSGGNATLIGNGGNGGNG
FT GVGSAPGKGGAGGTAGLLGLNGSPGLS"
FT CDS complement(107074..109269)
FT /transl_table=11
FT /gene="glgB"
FT /locus_tag="Rv1326c"
FT /product="PROBABLE 1,4-ALPHA-GLUCAN BRANCHING ENZYME GLGB
FT (GLYCOGEN BRANCHING ENZYME)"
FT /function="INVOLVED IN GLYCOGEN BIOSYNTHESIS (CYTOPLASMIC
FT POLYSACCHARIDES) (THIRD STEP) [CATALYTIC ACTIVITY :
FT FORMATION OF 1,6-GLUCOSIDIC LINKAGES OF GLYCOGEN]."
FT /EC_number="2.4.1.18"
FT /note="Rv1326c, (MTCY130.11c), len: 731 aa. Probable glgB,
FT 1,4-alpha-glucan branching enzyme (EC 2.4.1.18), similar to
FT others e.g. GLGB_ECOLI|P07762 Escherichia coli (728 aa),
FT FASTA scores: opt: 2330, E(): 0, (48.7% identity in 719 aa
FT overlap). Similar to other Mycobacterium tuberculosis
FT putative alpha-glucan branching enzymes Rv1562c, Rv1563c.
FT BELONGS TO FAMILY 13 OF GLYCOSYL HYDROLASES, ALSO KNOWN AS
FT THE ALPHA-AMYLASE FAMILY."
FT /db_xref="GOA:Q10625"
FT /db_xref="InterPro:IPR004193"
FT /db_xref="InterPro:IPR006047"
FT /db_xref="InterPro:IPR006048"
FT /db_xref="InterPro:IPR006407"
FT /db_xref="InterPro:IPR013780"
FT /db_xref="InterPro:IPR013781"
FT /db_xref="InterPro:IPR013783"
FT /db_xref="InterPro:IPR014756"
FT /db_xref="InterPro:IPR017853"
FT /db_xref="UniProtKB/Swiss-Prot:Q10625"
FT /protein_id="CAA98090.1"
FT /translation="MSRSEKLTGEHLAPEPAEMARLVAGTHHNPHGILGAHEYDDHTVI
FT RAFRPHAVEVVALVGKDRFSLQHLDSGLFAVALPFVDLIDYRLQVTYEGCEPHTVADAY
FT RFLPTLGEVDLHLFAEGRHERLWEVLGAHPRSFTTADGVVSGVSFAVWAPNAKGVSLIG
FT EFNGWNGHEAPMRVLGPSGVWELFWPDFPCDGLYKFRVHGADGVVTDRADPFAFGTEVP
FT PQTASRVTSSDYTWGDDDWMAGRALRNPVNEAMSTYEVHLGSWRPGLSYRQLARELTDY
FT IVDQGFTHVELLPVAEHPFAGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQAGIGVIV
FT DWVPAHFPKDAWALGRFDGTPLYEHSDPKRGEQLDWGTYVFDFGRPEVRNFLVANALYW
FT LQEFHIDGLRVDAVASMLYLDYSRPEGGWTPNVHGGRENLEAVQFLQEMNATAHKVAPG
FT IVTIAEESTPWSGVTRPTNIGGLGFSMKWNMGWMHDTLDYVSRDPVYRSYHHHEMTFSM
FT LYAFSENYVLPLSHDEVVHGKGTLWGRMPGNNHVKAAGLRSLLAYQWAHPGKQLLFMGQ
FT EFGQRAEWSEQRGLDWFQLDENGFSNGIQRLVRDINDIYRCHPALWSLDTTPEGYSWID
FT ANDSANNVLSFMRYGSDGSVLACVFNFAGAEHRDYRLGLPRAGRWREVLNTDATIYHGS
FT GIGNLGGVDATDDPWHGRPASAVLVLPPTSALWLTPA"
FT CDS complement(109277..111382)
FT /transl_table=11
FT /gene="glgE"
FT /locus_tag="Rv1327c"
FT /product="PROBABLE GLUCANASE GLGE"
FT /function="UNKNOWN; PROBABLY INVOLVED IN POLYSACCHARIDES
FT DEGRADATION."
FT /note="Rv1327c, (MTCY130.12c), len: 701 aa. Probable glgE,
FT glucanase, similar to AF172946|AF172946_2 putative
FT glucanase GlgE from Mycobacterium smegmatis (697 aa), FASTA
FT scores: opt: 3816, E(): 0, (78.5% identity in 692 aa
FT overlap). Similar to putative alpha-amylases e.g. Q9L1K2
FT Streptomyces coelicolor (675 aa), FASTA scores: opt: 2243,
FT E(): 7.4e-132, (54.2% identity in 684 aa overlap). Start
FT changed since original submission (-36) based on similarity
FT to GlgE of Mycobacterium smegmatis; previous start at
FT position 1494531."
FT /db_xref="GOA:P63531"
FT /db_xref="InterPro:IPR006047"
FT /db_xref="InterPro:IPR013781"
FT /db_xref="InterPro:IPR017853"
FT /db_xref="UniProtKB/Swiss-Prot:P63531"
FT /protein_id="CAA98091.2"
FT /translation="MSGRAIGTETEWWVPGRVEIDDVAPVVSCGVYPAKAVVGEVVPVS
FT AAVWREGHEAVAATLVVRYLGVRYPHLTDRPRARVLPTPSEPQQRVKPLLIPMTSGQEP
FT FVFHGQFTPDRVGLWTFRVDGWGDPIHTWRHGLIAKLDAGQGETELSNDLLVGAVLLER
FT AATGVPRGLRDPLLAAAAALRTPGDPVTRTALALTPEIEELLADYPLRDLVTRGEQFGV
FT WVDRPLARFGAWYEMFPRSTGGWDDDGNPVHGTFATAAAELPRIAGMGFDVVYLPPIHP
FT IGKVHRKGRNNSPTAAPTDVGSPWAIGSDEGGHDTVHPSLGTIDDFDDFVSAARDLGME
FT VALDLALQCAPDHPWAREHRQWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPEGLYDE
FT VLRVVQHWVNHGVKFFRVDNPHTKPPNFWAWLIAQVKTVDPDVLFLSEAFTPPARQYGL
FT AKLGFTQSYSYFTWRTTKWELTEFGNQIAELADYRRPNLFVNTPDILHAVLQHNGPGMF
FT AIRAVLAATMSPAWGMYCGYELFEHRAVREGSEEYLDSEKYELRPRDFASALDQGRSLQ
FT PFITRLNIIRRLHPAFQQLRTIHFHHVDNDALLAYSKFDPATGDCVLVVVTLNAFGPEE
FT ATLWLDMAALGMEDYDRFWVRDEITGEEYQWGQANYIRIDPARAVAHIINMPAVPYESR
FT NTLLRRR"
FT CDS 111521..114112
FT /transl_table=11
FT /gene="glgP"
FT /locus_tag="Rv1328"
FT /product="PROBABLE GLYCOGEN PHOSPHORYLASE GLGP"
FT /function="PHOSPHORYLASE IS AN IMPORTANT ALLOSTERIC ENZYME
FT IN CARBOHYDRATE METABOLISM. ENZYMES FROM DIFFERENT SOURCES
FT DIFFER IN THEIR REGULATORY MECHANISMS AND IN THEIR NATURAL
FT SUBSTRATES. HOWEVER, ALL KNOWN PHOSPHORYLASES SHARE
FT CATALYTIC AND STRUCTURAL PROPERTIES [CATALYTIC ACTIVITY :
FT {(1,4)-ALPHA-D-GLUCOSYL}(N) + PHOSPHATE =
FT {(1,4)-ALPHA-D-GLUCOSYL}(N-1) + ALPHA-D-GLUCOSE
FT 1-PHOSPHATE]."
FT /EC_number="2.4.1.1"
FT /note="Rv1328, (MTCY130.13), len: 863 aa. Probable glgP,
FT glycogen phosphorylase (EC 2.4.1.1), similar to many e.g.
FT PHSG_HAEIN|P45180 glycogen phosphorylase from Haemophilus
FT influenzae (821 aa), FASTA scores: E(): 6.9e-08, (25.6%
FT identity in 675 aa overlap). BELONGS TO THE GLYCOGEN
FT PHOSPHORYLASE FAMILY."
FT /db_xref="GOA:Q10639"
FT /db_xref="InterPro:IPR000811"
FT /db_xref="InterPro:IPR011834"
FT /db_xref="UniProtKB/Swiss-Prot:Q10639"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA98092.1"
FT /translation="MKALRRFTVRAHLPERLAALDQLSTNLRWSWDKPTQDLFAAIDPA
FT LWEQCGHDPVALLGAVNPARLDELALDAEFLGALDELAADLNDYLSRPLWYQEQQDAGV
FT AAQALPTGIAYFSLEFGVAEVLPNYSGGLGILAGDHLKSASDLGVPLIAVGLYYRSGYF
FT RQSLTADGWQHETYPSLDPQGLPLRLLTDANGDPVLVEVALGDNAVLRARIWVAQVGRV
FT PLLLLDSDIPENEHDLRNVTDRLYGGDQEHRIKQEILAGIGGVRAIRAYTAVEKLTPPE
FT VFHMNEGHAGFLGIERIRELVTDAGLDFDTALTVVRSSTVFTTHTPVPAGIDRFPLEMV
FT QRYVNDQRGDGRSRLLPGLPADRIVALGAEDDPAKFNMAHMGLRLAQRANGVSLLHGRV
FT SRAMFNELWAGFDPDEVPIGSVTNGVHAPTWAAPQWLQLGRELAGSDSLREPVVWQRLH
FT QVDPAHLWWIRSQLRSMLVEDVRARLRQSWLERGATDAELGWIATAFDPNVLTVGFARR
FT VPTYKRLTLMLRDPDRLEQLLLDEQRPIQLIVAGKSHPADDGGKALIQQVVRFADRPQV
FT RHRIAFLPNYDMSMARLLYWGCDVWLNNPLRPLEACGTSGMKSALNGGLNLSIRDGWWD
FT EWYDGENGWEIPSADGVADENRRDDLEAGALYDLLAQAVAPKFYERDERGVPQRWVEMV
FT RHTLQTLGPKVLASRMVRDYVEHYYAPAAQSFRRTAGAQFDAARELADYRRRAEEAWPK
FT IEIADVDSTGLPDTPLLGSQLTLTATVRLAGLRPNDVTVQGVLGRVDAGDVLMDPVTVE
FT MAHTGTGDGGYEIFSTTTPLPLAGPVGYTVRVLPRHPMLAASNELGLVTLA"
FT CDS complement(114152..116146)
FT /transl_table=11
FT /gene="dinG"
FT /locus_tag="Rv1329c"
FT /product="PROBABLE ATP-DEPENDENT HELICASE DING"
FT /function="PROBABLE HELICASE INVOLVED IN DNA REPAIR AND
FT PERHAPS ALSO REPLICATION."
FT /note="Rv1329c, (MTCY130.14c), len: 664 aa. Probable dinG,
FT ATP-dependent helicase (see citation below), similar to
FT several e.g. DING_HAEIN|P44680 probable ATP-dependent
FT helicase ding from Haemophilus influenzae (640 aa), FASTA
FT scores: opt: 685, E(): 2.3e-38, (32.8% identity in 644 aa
FT overlap). Contains PS00017 ATP/GTP-binding site motif A."
FT /db_xref="GOA:P64314"
FT /db_xref="InterPro:IPR006555"
FT /db_xref="InterPro:IPR011545"
FT /db_xref="InterPro:IPR014001"
FT /db_xref="InterPro:IPR014013"
FT /db_xref="UniProtKB/Swiss-Prot:P64314"
FT /protein_id="CAA98093.1"
FT /translation="MSESVSMSVPELLAIAVAALGGTRRRGQQEMAAAVAHAFETGEHL
FT VVQAGTGTGKSLAYLVPAIIRALCDDAPVVVSTATIALQRQLVDRDLPQLVDSLTNALP
FT RRPKFALLKGRRNYLCLNKIHNSVTASDHDDERPQEELFDPVAVTALGRDVQRLTAWAS
FT TTVSGDRDDLKPGVGDRSWSQVSVSARECLGVARCPFGSECFSERARGAAGLADVVVTN
FT HALLAIDAVAESAVLPEHRLLVVDEAHELADRVTSVAAAELTSATLGMAARRITRLVDP
FT KVTQRLQAASATFSSAIHDARPGRIDCLDDEMATYLSALRDAASAARSAIDTGSDTTTA
FT SVRAEAGAVLTEISDTASRILASFAPAIPDRSDVVWLEHEDNHESARAVLRVAPLSVAE
FT LLATQVFARATTVLTSATLTIGGSFDAMATAWGLTADTPWRGLDVGSPFQHAKSGILYV
FT AAHLPPPGRDGSGSAEQLTEIAELITAAGGRTLGLFSSMRAARAATEAMRERLSTPVLC
FT QGDDSTSTLVEKFTADAATSLFGTLSLWQGVDVPGPSLSLVLIDRIPFPRPDDPLLSAR
FT QRAVAARGGNGFMTVAASHAALLLAQGSGRLLRRVTDRGVVAVLDSRMATARYGEFLRA
FT SLPPFWQTTNATQVRAALRRLARADAKAH"
FT misc_feature complement(115979..116002)
FT /note="PS00017 ATP/GTP-binding site motif A"
FT CDS complement(116170..117516)
FT /transl_table=11
FT /locus_tag="Rv1330c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1330c, (MTCY130.15c), len: 448 aa. Conserved
FT hypothetical protein, similar to others and also several
FT nicotinate phosphoribosyltransferases e.g. O32090 YUEK
FT PROTEIN from Bacillus subtilis (490 aa), FASTA scores: E():
FT 8.6e-22, (37.9% identity in 369 aa overlap). Also similar
FT to Mycobacterium tuberculosis Rv0573c|MTV039.11c (38.0%
FT identity in 437 aa overlap). Start changed since original
FT submission based on similarity; previous start at position
FT 1500740 (-61 aa)."
FT /db_xref="GOA:Q10641"
FT /db_xref="InterPro:IPR006405"
FT /db_xref="InterPro:IPR007229"
FT /db_xref="InterPro:IPR015977"
FT /db_xref="UniProtKB/Swiss-Prot:Q10641"
FT /protein_id="CAA98094.2"
FT /translation="MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPT
FT TFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFR
FT GDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGR
FT PLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHG
FT GPTELAERAAFRAQVEALGPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVL
FT ARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVY
FT KLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTL
FT PLVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA"
FT CDS 117618..117923
FT /transl_table=11
FT /locus_tag="Rv1331"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1331, (MTCY130.16), len: 101 aa. Conserved
FT hypothetical protein, highly similar to U00014|ML014
FT B1549_C2_207 from Mycobacterium leprae (94 aa), FASTA
FT scores: opt: 573, E(): 2.9e-40, (90.3% identity in 93 aa
FT overlap). Similar to AL096852|SCE19A_16 hypothetical
FT protein from Streptomyces coelicolor (105 aa), FASTA
FT scores: opt: 377, E(): 2.9e-22, (60.0% identity in 105 aa
FT overlap)."
FT /db_xref="GOA:P67647"
FT /db_xref="InterPro:IPR003769"
FT /db_xref="InterPro:IPR014719"
FT /db_xref="UniProtKB/Swiss-Prot:P67647"
FT /protein_id="CAA98095.1"
FT /translation="MAVVSAPAKPGTTWQRESAPVDVTDRAWVTIVWDDPVNLMSYVTY
FT VFQKLFGYSEPHATKLMLQVHNEGKAVVSAGSRESMEVDVSKLHAAGLWATMQQDR"
FT CDS 117883..118539
FT /transl_table=11
FT /locus_tag="Rv1332"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM."
FT /note="Rv1332, (MTCY130.17), len: 218 aa. Possible
FT regulatory protein, high similarity to ML014|U00014 M.
FT leprae B1549_C3_236 (222 aa), FASTA scores: opt: 1158, E():
FT 0, (75.6% identity in 221 aa overlap). Helix turn helix
FT motif fram aa 8-29 (+3.03 SD)."
FT /db_xref="InterPro:IPR018561"
FT /db_xref="UniProtKB/Swiss-Prot:P64809"
FT /protein_id="CAA98096.1"
FT /translation="MPPVCGRRCSRTGEIRGYSGSIVRRWKRVETRDGPRFRSSLAPHE
FT AALLKNLAGAMIGLLDDRDSSSPSDELEEITGIKTGHAQRPGDPTLRRLLPDFYRPDDL
FT DDDDPTAVDGSESFNAALRSLHEPEIIDAKRVAAQQLLDTVPDNGGRLELTESDANAWI
FT AAVNDLRLALGVMLEIGPRGPERLPGNHPLAAHFNVYQWLTVLQEYLVLVLMGSR"
FT CDS 118556..119590
FT /transl_table=11
FT /locus_tag="Rv1333"
FT /product="PROBABLE HYDROLASE"
FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT METABOLISM"
FT /EC_number="3.-.-.-"
FT /note="Rv1333, (MTCY130.18), len: 344 aa. Possible
FT hydrolase (EC 3.-.-.-), similar to Q57326|D26094 endo-type
FT 6-aminohexanoate oligomer hydrolase (355 aa), fasta scores:
FT E(): 1.4e-10, (31.9% identity in 339 aa overlap).
FT Equivalent to P53425|YD33_MYCLE HYPOTHETICAL 36.1 KD
FT PROTEIN B154 Mycobacterium leprae (362 aa), FASTA scores:
FT opt: 1735, E(): 0, (76.7% identity in 352 aa overlap)."
FT /db_xref="GOA:P64811"
FT /db_xref="InterPro:IPR005321"
FT /db_xref="InterPro:IPR016117"
FT /db_xref="UniProtKB/Swiss-Prot:P64811"
FT /protein_id="CAA98097.1"
FT /translation="MNSITDVGGIRVGHYQRLDPDASLGAGWACGVTVVLPPPGTVGAV
FT DCRGGAPGTRETDLLDPANSVRFVDALLLAGGSAYGLAAADGVMRWLEEHRRGVAMDSG
FT VVPIVPGAVIFDLPVGGWNCRPTADFGYSACAAAGVDVAVGTVGVGVGARAGALKGGVG
FT TASATLQSGVTVGVLAVVNAAGNVVDPATGLPWMADLVGEFALRAPPAEQIAALAQLSS
FT PLGAFNTPFNTTIGVIACDAALSPAACRRIAIAAHDGLARTIRPAHTPLDGDTVFALAT
FT GAVAVPPEAGVPAALSPETQLVTAVGAAAADCLARAVLAGVLNAQPVAGIPTYRDMFPG
FT AFGS"
FT CDS 119598..120038
FT /transl_table=11
FT /locus_tag="Rv1334"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1334, (MTCY130.19), len: 146 aa. Conserved
FT hypothetical protein, similar to AL096852|SCE19A_13
FT hypothetical protein from Streptomyces coelicolor (140 aa),
FT Fasta scores: opt: 579, E(): 0, (65.0% identity in 140 aa
FT overlap); and Q54330|M29166 MEC+ from Streptomyces
FT kasugaensis (115 aa), FASTA scores; E(): 7.6e-33, (56.9%
FT identity in 109 aa overlap)."
FT /db_xref="InterPro:IPR000555"
FT /db_xref="UniProtKB/Swiss-Prot:P64813"
FT /protein_id="CAA98098.1"
FT /translation="MLLRKGTVYVLVIRADLVNAMVAHARRDHPDEACGVLAGPEGSDR
FT PERHIPMTNAERSPTFYRLDSGEQLKVWRAMEDADEVPVVIYHSHTATEAYPSRTDVKL
FT ATEPDAHYVLVSTRDPHRHELRSYRIVDGAVTEEPVNVVEQY"
FT CDS 120060..120341
FT /transl_table=11
FT /locus_tag="Rv1335"
FT /product="9.5 KDA CULTURE FILTRATE ANTIGEN CFP10A"
FT /function="UNKNOWN"
FT /note="Rv1335, (MT1376.1, MTCY130.20), len: 93 aa. 9.5 kDa
FT culture filtrate antigen cfp10A (see citation below).
FT Similar to hypothetical proteins from other organisms e.g.
FT P74060|D90911 Synechocystis (109 aa), FASTA scores: E():
FT 2.3e-20, (49.5% identity in 93 aa overlap)."
FT /db_xref="GOA:P0A646"
FT /db_xref="InterPro:IPR003749"
FT /db_xref="InterPro:IPR012675"
FT /db_xref="InterPro:IPR016155"
FT /db_xref="PDB:3DWG"
FT /db_xref="PDB:3DWM"
FT /db_xref="UniProtKB/Swiss-Prot:P0A646"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA98099.1"
FT /translation="MNVTVSIPTILRPHTGGQKSVSASGDTLGAVISDLEANYSGISER
FT LMDPSSPGKLHRFVNIYVNDEDVRFSGGLATAIADGDSVTILPAVAGG"
FT CDS 120351..121322
FT /transl_table=11
FT /gene="cysM"
FT /locus_tag="Rv1336"
FT /product="PROBABLE CYSTEINE SYNTHASE B CYSM (CSASE B)
FT (O-acetylserine sulfhydrylase B) (O-acetylserine
FT (Thiol)-lyase B)"
FT /function="INVOLVED IN CYSTEINE BIOSYNTHESIS [CATALYTIC
FT ACTIVITY : O3-ACETYL-L-SERINE + H(2)S = L-CYSTEINE +
FT ACETATE]"
FT /EC_number="2.5.1.47"
FT /note="Rv1336, (MTCY130.21), len: 323 aa. Probable cysM,
FT cysteine synthase B (EC 4.2.99.8), similar to many e.g.
FT CYSM_ECOLI|P16703 Escherichia coli (303 aa), FASTA scores:
FT opt: 720, E(): 4.6e-40, (41.1% identity in 302 aa overlap).
FT Also similar to other Mycobacterium tuberculosis cysteine
FT synthase subunits e.g. Rv1077, Rv2334, Rv0848, etc.
FT Contains PS00901 Cysteine synthase/cystathionine
FT beta-synthase P-phosphate attachment site. BELONGS TO THE
FT CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY."
FT /db_xref="GOA:P63873"
FT /db_xref="InterPro:IPR001216"
FT /db_xref="InterPro:IPR001926"
FT /db_xref="InterPro:IPR005856"
FT /db_xref="PDB:3DKI"
FT /db_xref="PDB:3DWG"
FT /db_xref="PDB:3DWI"
FT /db_xref="PDB:3FGP"
FT /db_xref="UniProtKB/Swiss-Prot:P63873"
FT /protein_id="CAA98100.1"
FT /translation="MTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRN
FT PTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMPEN
FT TSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDSHYC
FT GTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYALRNM
FT DEGFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGAL
FT AAGERADIALVVADAGWKYLSTGAYAGSLDDAETALEGQLWA"
FT misc_feature 120468..120524
FT /note="PS00901 Cysteine synthase/cystathionine
FT beta-synthase P-phosphate attachment site"
FT CDS 121313..122035
FT /transl_table=11
FT /locus_tag="Rv1337"
FT /product="PROBABLE INTEGRAL MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1337, (MTCY130.22), len: 240 aa. Probable integral
FT membrane protein. Highly similar to P53426 hypothetical
FT protein B1549_C3_240 from M.leprae (251); and P74553|D90916
FT hypothetical protein from Synechocystis sp. (198 aa), FASTA
FT scores: E(): 2.3e-25, (43.6% identity in 181 aa overlap)."
FT /db_xref="GOA:P64815"
FT /db_xref="InterPro:IPR002610"
FT /db_xref="UniProtKB/Swiss-Prot:P64815"
FT /protein_id="CAA98101.1"
FT /translation="MGMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTILT
FT FVALLYLVELIDQLSGSRLDVNGIRPLKTDGLWGVIFAPLLHANWHHLMANTIPLLVLG
FT FLMTLAGLSRFVWATAIIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLLVFG
FT LFVRKGWDIVIGLVVLFVYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLLSAPE
FT RKARALKRAGARSGHPKL"
FT CDS 122032..122847
FT /transl_table=11
FT /gene="murI"
FT /locus_tag="Rv1338"
FT /product="PROBABLE GLUTAMATE RACEMASE MURI"
FT /function="INVOLVED IN PEPTIDOGLYCAN BIOSYNTHESIS. PROVIDES
FT THE (R)-GLUTAMIC ACID REQUIRED FOR CELL WALL BIOSYNTHESIS
FT [CATALYTIC ACTIVITY : L-GLUTAMATE = D-GLUTAMATE]"
FT /EC_number="5.1.1.3"
FT /note="Rv1338, (MTCY130.23), len: 271 aa. Probable murI,
FT glutamate racemase (EC 5.1.1.3), highly similar to many
FT e.g. MURI_MYCLE|P46705 (272 aa), FASTA scores: opt: 1559,
FT E(): 0, (88.9% identity in 271 aa overlap). Contains
FT PS00924 Aspartate and glutamate racemases signature 2."
FT /db_xref="GOA:P63635"
FT /db_xref="InterPro:IPR001920"
FT /db_xref="InterPro:IPR004391"
FT /db_xref="InterPro:IPR015942"
FT /db_xref="InterPro:IPR018187"
FT /db_xref="UniProtKB/Swiss-Prot:P63635"
FT /protein_id="CAA98102.1"
FT /translation="MNSPLAPVGVFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYG
FT PLTIPEIRAHALAIGDDLVGRGVKALVIACNSASSACLRDARERYQVPVVEVILPAVRR
FT AVAATRNGRIGVIGTRATITSHAYQDAFAAARDTEITAVACPRFVDFVERGVTSGRQVL
FT GLAQGYLEPLQRAEVDTLVLGCTHYPLLSGLIQLAMGENVTLVSSAEETAKEVVRVLTE
FT IDLLRPHDAPPATRIFEATGDPEAFTKLAARFLGPVLGGVQPVHPSRIH"
FT misc_feature 122572..122604
FT /note="PS00924 Aspartate and glutamate racemases signature
FT 2"
FT CDS 122874..123695
FT /transl_table=11
FT /locus_tag="Rv1339"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1339, (MTCY130.24), len: 273 aa. Conserved
FT hypothetical protein, highly similar to Y211_MYCLE|P50474
FT hypothetical protein b1549_c2_211 from Mycobacterium leprae
FT (284 aa), FASTA scores: opt: 1672, E(): 0, (86.2% identity
FT in 276 aa overlap). Also similar to AL096852|SCE19A.08
FT hypothetical protein from Streptomyces coelicolor (250 aa),
FT FASTA scores: opt: 630, E(): 0, (42.2% identity in 256 aa
FT overlap). Similar to M. tuberculosis hypothetical proteins
FT Rv3796, Rv2407."
FT /db_xref="GOA:P66873"
FT /db_xref="InterPro:IPR001279"
FT /db_xref="UniProtKB/Swiss-Prot:P66873"
FT /protein_id="CAA99972.1"
FT /translation="MRRCIPHRCIGHGTVVSVRITVLGCSGSVVGPDSPASGYLLRAPH
FT TPPLVIDFGGGVLGALQRHADPASVHVLLSHLHADHCLDLPGLFVWRRYHPSRPSGKAL
FT LYGPSDTWSRLGAASSPYGGEIDDCSDIFDVHHWADSEPVTLGALTIVPRLVAHPTESF
FT GLRITDPSGASLAYSGDTGICDQLVELARGVDVFLCEASWTHSPKHPPDLHLSGTEAGM
FT VAAQAGVRELLLTHIPPWTSREDVISEAKAEFDGPVHAVVCDETFEVRRAG"
FT CDS 123712..124491
FT /transl_table=11
FT /gene="rphA"
FT /locus_tag="Rv1340"
FT /product="PROBABLE RIBONUCLEASE RPHA (RNase PH) (tRNA
FT nucleotidyltransferase)"
FT /function="RNase PH IS A PHOSPHOROLYTIC EXORIBONUCLEASE
FT THAT REMOVES NUCLEOTIDE RESIDUES FOLLOWING THE -CCA
FT TERMINUS OF tRNA AND ADDS NUCLEOTIDES TO THE ENDS OF RNA
FT MOLECULES BY USING NUCLEOSIDE DIPHOSPHATES AS SUBSTRATES
FT [CATALYTIC ACTIVITY: {TRNA}(N+1) + PHOSPHATE = {TRNA}(N) +
FT A NUCLEOSIDE DIPHOSPHATE]."
FT /EC_number="2.7.7.56"
FT /note="Rv1340, (MTCY130.25), len: 259 aa. Probable rphA,
FT Ribonuclease ph (EC 2.7.7.56), highly similar to others
FT e.g. RNPH_MYCLE|P37939 Mycobacterium leprae (259 aa), FASTA
FT scores: opt: 1524, E(): 0, (88.8% identity in 259 aa
FT overlap). BELONGS TO THE RNASE PH FAMILY."
FT /db_xref="GOA:Q10628"
FT /db_xref="InterPro:IPR001247"
FT /db_xref="InterPro:IPR002381"
FT /db_xref="InterPro:IPR015847"
FT /db_xref="InterPro:IPR018336"
FT /db_xref="InterPro:IPR020568"
FT /db_xref="PDB:3B4T"
FT /db_xref="UniProtKB/Swiss-Prot:Q10628"
FT /protein_id="CAA99973.1"
FT /translation="MSKREDGRLDHELRPVIITRGFTENPAGSVLIEFGHTKVLCTASV
FT TEGVPRWRKATGLGWLTAEYAMLPSATHSRSDRESVRGRLSGRTQEISRLIGRSLRACI
FT DLAALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLSAAGKLSDPRPLSCAIA
FT AVSVGVVDGRIRVDLPYEEDSRAEVDMNVVATDTGTLVEIQGTGEGATFARSTLDKLLD
FT MALGACDTLFAAQRDALALPYPGVLPQGPPPPKAFGT"
FT repeat_region 124488..124538
FT /note="51 bp Mycobacterial Interspersed Repetitive Unit,
FT Class II"
FT CDS 124530..125144
FT /transl_table=11
FT /locus_tag="Rv1341"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1341, (MTCY130.26), len: 204 aa. Conserved
FT hypothetical protein, some similarity to P52061|YGGV_ECOLI
FT HYPOTHETICAL PROTEIN yggV (197 aa), FASTA scores: opt: 521,
FT E(): 7.9e-27, (46.0% identity in 200 aa overlap).
FT Equivalent to ML014|U00014 hypothetical protein
FT B1549_C2_213 from Mycobacterium leprae (285 aa), FASTA
FT scores: opt: 1073, E(): 0, (83.0% identity in 206 aa
FT overlap)."
FT /db_xref="GOA:P64307"
FT /db_xref="InterPro:IPR002637"
FT /db_xref="UniProtKB/Swiss-Prot:P64307"
FT /protein_id="CAA99974.1"
FT /translation="MALVTKLLVASRNRKKLAELRRVLDGAGLSGLTLLSLGDVSPLPE
FT TPETGVTFEDNALAKARDAFSATGLASVADDSGLEVAALGGMPGVLSARWSGRYGDDAA
FT NTALLLAQLCDVPDERRGAAFVSACALVSGSGEVVVRGEWPGTIAREPRGDGGFGYDPV
FT FVPYGDDRTAAQLSPAEKDAVSHRGRALALLLPALRSLATG"
FT CDS complement(125141..125503)
FT /transl_table=11
FT /locus_tag="Rv1342c"
FT /product="CONSERVED MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1342c, (MTCY02B10.06c), len: 120 aa. Conserved
FT membrane protein. Highly similar to G466926|P54133
FT hypothetical protein B1549_F2_59 from Mycobacterium leprae
FT (119 aa), FASTA scores, opt: 544, E(): 1.9e-29, (68.3 %
FT identity in 120 aa overlap)."
FT /db_xref="GOA:P0A5E7"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5E7"
FT /protein_id="CAE55378.1"
FT /translation="MTAPETPAAQHAEPAIAVERIRTALLGYRIMAWTTGLWLIALCYE
FT IVVRYVVKVDNPPTWIGVVHGWVYFTYLLLTLNLAVKVRWPLGKTAGVLLAGTIPLLGI
FT VVEHFQTKEIKARFGL"
FT CDS complement(125500..125880)
FT /transl_table=11
FT /gene="lprD"
FT /locus_tag="Rv1343c"
FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRD"
FT /function="UNKNOWN"
FT /note="Rv1343c, (MTCY02B10.07c), len: 126 aa. Probable
FT lprD, conserved lipoprotein, highly similar to G466928
FT Mycobacterium leprae protein B1549_F3_106 (126 aa), FASTA
FT scores, opt: 704, E(): 7.5e-36, (78.4 % identity in 125 aa
FT overlap). Has N-terminal signal sequence and appropriately
FT positioned prokaryotic lipoprotein attachment site.
FT Contains PS00013 Prokaryotic membrane lipoprotein lipid
FT attachment site."
FT /db_xref="GOA:Q11013"
FT /db_xref="UniProtKB/Swiss-Prot:Q11013"
FT /protein_id="CAA99976.1"
FT /translation="MSTTRRRRPALIALVIIATCGCLALGWWQWTRFQSTSGTFQNLGY
FT ALQWPLFAWFCVYAYRNFVRYEETPPQPPTGGAAAEIPAGLLPERPKPAQQPPDDPVLR
FT EYNAYLAELAKDDARKQNRTTA"
FT CDS 125925..126245
FT /transl_table=11
FT /locus_tag="Rv1344"
FT /product="PROBABLE ACYL CARRIER PROTEIN (ACP)"
FT /function="THOUGHT TO BE INVOLVED IN DE NOVO FATTY ACID
FT BIOSYNTHESIS; THIS PROTEIN IS THE CARRIER OF THE GROWING
FT FATTY ACID CHAIN IN FATTY ACID BIOSYNTHESIS"
FT /note="Rv1344, (MTCY02B10.08), len: 106 aa. Possible acyl
FT carrier protein, similar to others e.g. ACP_RHIME|P19372
FT Rhizobium meliloti (77 aa), FASTA scores: opt: 117, E():
FT 0.03, (29.9% identity in 67 aa overlap) and
FT ACP_SYNY3|P20804 acyl carrier protein (acp) from
FT Synechocystis sp (77 aa), FASTA scores: E(): 7.1e-05,
FT (34.8% identity in 66 aa overlap). Also similar to Rv2244
FT and Rv0033 from Mycobacterium tuberculosis."
FT /db_xref="GOA:P63452"
FT /db_xref="InterPro:IPR006163"
FT /db_xref="InterPro:IPR009081"
FT /db_xref="UniProtKB/Swiss-Prot:P63452"
FT /protein_id="CAA99977.1"
FT /translation="MWRYPLSTRLALPNTPGVASFAMTSSPSTVSTTLLSILRDDLNID
FT LTRVTPDARLVDDVGLDSVAFAVGMVAIEERLGVALSEEELLTCDTVGELEAAIAAKYR
FT DE"
FT CDS 126238..127803
FT /transl_table=11
FT /gene="fadD33"
FT /locus_tag="Rv1345"
FT /product="POSSIBLE POLYKETIDE SYNTHASE FADD33"
FT /function="UNKNOWN, BUT POSSIBLY INVOLVED IN LIPID
FT DEGRADATION."
FT /note="Rv1345, (MTCY02B10.09), len: 521 aa. Possible
FT fadD33, polyketide synthase, similar to N-terminus of
FT T34918 polyketide synthase from Streptomyces coelicolor
FT (2297 aa); and PKSJ_BACSU|P40806 putative polyketide
FT biosynthesis protein from Bacillus subtilis (557 aa), FASTA
FT scores: opt: 537, E(): 8.2e-27, (27.1% identity in 468 aa
FT overlap). Also similar to other proteins from Mycobacterium
FT tuberculosis eg Rv1013|MTCI237.30|MTCY10G2.36c|pks16
FT PUTATIVE POLYKETIDE SYNTHASE (544 aa); etc."
FT /db_xref="GOA:P0A4X8"
FT /db_xref="InterPro:IPR000873"
FT /db_xref="InterPro:IPR020845"
FT /db_xref="UniProtKB/Swiss-Prot:P0A4X8"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA99978.1"
FT /translation="MSELAAVLTRSMQASAGDLMVLDRETSLWCRHPWPEVHGLAESVA
FT AWLLDHDRPAAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGANDQRWADATLTRF
FT LGIGVRTVLSQGSYLARLRSVDTAGVTIGDLSTAAHTNRSATPVASEGPAVLQGTAGST
FT GAPRTAILSPGAVLSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLAFVLSAALAGAPLW
FT LAPTTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARRVSEVDLGALRVTLNGGE
FT PVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPVPGIGLLADRVIDGSGAHK
FT HAVLGNPIPGMEVRISCGDQAAGNASREIGEIEIRGASMMAGYLGQQPIDPDDWFATGD
FT LGYLGAGGLVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDRSTRPG
FT LVVAAEFRGPDEANARAELIQRVASECGIVPSDVVFVSPGSLPRTSSGKLRRLAVRRSL
FT EMAD"
FT CDS 127803..128963
FT /transl_table=11
FT /gene="fadE14"
FT /locus_tag="Rv1346"
FT /product="POSSIBLE ACYL-CoA DEHYDROGENASE FADE14"
FT /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION."
FT /EC_number="1.3.99.-"
FT /note="Rv1346, (MTCY02B10.10), len: 386 aa. Possible
FT fadE14, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to
FT many e.g. NP_251579.1|NC_002516 probable acyl-CoA
FT dehydrogenase from Pseudomonas aeruginosa (386 aa);
FT NP_036951.1|NM_012819|ACDL_RAT|P15650 acyl Coenzyme A
FT dehydrogenase (long chain) from Rattus norvegicus (430 aa),
FT FASTA scores: opt: 414, E(): 1.2e-18, (26.1% identity in
FT 376 aa overlap); etc."
FT /db_xref="GOA:P63431"
FT /db_xref="InterPro:IPR006090"
FT /db_xref="InterPro:IPR006091"
FT /db_xref="InterPro:IPR009075"
FT /db_xref="InterPro:IPR009100"
FT /db_xref="InterPro:IPR013764"
FT /db_xref="UniProtKB/Swiss-Prot:P63431"
FT /protein_id="CAA99979.1"
FT /translation="MTAGSDLDDFRGLLAKAFDERVVAWTAEAEAQERFPRQLIEHLGV
FT CGVFDAKWATDARPDVGKLVELAFALGQLASAGIGVGVSLHDSAIAILRRFGKSDYLRD
FT ICDQAIRGAAVLCIGASEESGGSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMV
FT VARSVDHDPTSRHGNVAVVAVPAAQVSVQTPYRKVGAGPLDTAAVCIDTWVPADALVAR
FT AGTGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQALRLRMA
FT DLQARVDLLRYALHGIAEQGRLELRTAAAVKVTAARLGEEVISECMHIFGGAGYLVDET
FT TLGKWWRDMKLARVGGGTDEVLWELVAAGMTPDHDGYAAVVGASKA"
FT CDS complement(128930..129562)
FT /transl_table=11
FT /locus_tag="Rv1347c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1347c, (MTCY02B10.11c), len: 210 aa. Conserved
FT hypothetical protein, some similarity to the C-terminus of
FT malonyl-coenzyme A carboxylases e.g. G545170
FT malonyl-coenzyme A carboxylase (417 aa), FASTA scores: opt:
FT 392, E(): 4.9 e-20, (35.6% identity in 174 aa overlap)."
FT /db_xref="GOA:P64819"
FT /db_xref="InterPro:IPR016181"
FT /db_xref="InterPro:IPR019432"
FT /db_xref="PDB:1YK3"
FT /db_xref="UniProtKB/Swiss-Prot:P64819"
FT /protein_id="CAA99980.1"
FT /translation="MTKPTSAGQADDALVRLARERFDLPDQVRRLARPPVPSLEPPYGL
FT RVAQLTDAEMLAEWMNRPHLAAAWEYDWPASRWRQHLNAQLEGTYSLPLIGSWHGTDGG
FT YLELYWAAKDLISHYYDADPYDLGLHAAIADLSKVNRGFGPLLLPRIVASVFANEPRCR
FT RIMFDPDHRNTATRRLCEWAGCKFLGEHDTTNRRMALYALEAPTTAA"
FT tRNA 129685..129768
FT /gene="tRNA-Leu(TAG)"
FT /product="transfer RNA-Leu(TAG)"
FT /anticodon=(pos:129719..129721,aa:Leu)
FT CDS 130004..132583
FT /transl_table=11
FT /locus_tag="Rv1348"
FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE
FT ATP-BINDING PROTEIN ABC TRANSPORTER"
FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE
FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO
FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE
FT SUBSTRATE ACROSS THE MEMBRANE."
FT /note="Rv1348, (MTCY02B10.12), len: 859 aa. Probable
FT drugs-transport transmembrane protein ATP binding protein
FT ABC transporter (see citation below), similar to
FT HMT1_SCHPO|Q02592 heavy metal tolerance protein precursor
FT from Schizosaccharomyces pombe (830 aa), FASTA scores: opt:
FT 806, E(): 5.1e-39, (32.9% identity in 504 aa overlap); etc.
FT Also similar to MTCY02B10.13 from Mycobacterium
FT tuberculosis, FASTA score: (31.9% identity in 576 aa
FT overlap). Contains PS00017 ATP/GTP-binding site motif A
FT (P-loop), and PS00211 ABC transporters family signature.
FT BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC
FT TRANSPORTERS)."
FT /db_xref="GOA:P63391"
FT /db_xref="InterPro:IPR001140"
FT /db_xref="InterPro:IPR003439"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR007037"
FT /db_xref="InterPro:IPR011527"
FT /db_xref="InterPro:IPR013113"
FT /db_xref="InterPro:IPR017871"
FT /db_xref="InterPro:IPR017927"
FT /db_xref="InterPro:IPR017938"
FT /db_xref="InterPro:IPR017940"
FT /db_xref="UniProtKB/Swiss-Prot:P63391"
FT /protein_id="CAA99981.1"
FT /translation="MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQD
FT AEAEPAAWLRFWFPDPNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWARTV
FT KPGATIAVMSLMGSSRFDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYLEQH
FT DDNDTLIPLAKHPRLRVRWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVRVRLR
FT DEFGFPKSEIHAQAYWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGSWRAQA
FT ASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLVSGAGAHRLFTVGFAAVGL
FT LGTGALLAAALTLWLHVIDARFARALRLRLLSKLSRLPLGWFTSRGSGSIKKLVTDDTL
FT ALHYLVTHAVPDAVAAVVAPVGVLVYLFVVDWRVALVLFGPVLVYLTITSSLTIQSGPR
FT IVQAQRWAEKMNGEAGSYLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTL
FT MDLATRPATFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRTG
FT LLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVPVIQDVSLTLRP
FT GTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIRSLAADELYTRVGFVLQEAQ
FT LVHGTAAENIALAVPDAPAEQVQVAAREAQIHDRVLRLPDGYDTVLGANSGLSGGERQR
FT LTIARAILGDTPVLILDEATAFADPESEYLVQQALNRLTRDRTVLVIAHRLHTITRADQ
FT IVVLDHGRIVERGTHEELLAAGGRYCRLWDTGQGSRVAVAAAQDGTR"
FT misc_feature 131930..131953
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature 132239..132283
FT /note="PS00211 ABC transporters family signature"
FT CDS 132580..134319
FT /transl_table=11
FT /locus_tag="Rv1349"
FT /product="PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE
FT ATP-BINDING PROTEIN ABC TRANSPORTER"
FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT DRUGS ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE
FT BY AN EXPORT MECHANISM. RESPONSIBLE FOR ENERGY COUPLING TO
FT THE TRANSPORT SYSTEM AND FOR THE TRANSLOCATION OF THE
FT SUBSTRATE ACROSS THE MEMBRANE."
FT /note="Rv1349, (MTCY02B10.13), len: 579 aa. Probable
FT drugs-transport transmembrane ATP binding protein ABC
FT transporter (see citation below), most similar to
FT YWJA_BACSU|P45861 hypothetical ABC transporter from
FT Bacillus subtilis (575 aa), FASTA scores: opt: 721, E():
FT 1.8e-35, (28.9% identity in 567 aa overlap); etc. Also
FT similar to MTCY02B10.12 from Mycobacterium tuberculosis,
FT FASTA score: (31.9% identity in 576 aa overlap). Contains
FT PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211
FT ABC transporters family signature. BELONGS TO THE
FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)."
FT /db_xref="GOA:P63393"
FT /db_xref="InterPro:IPR003439"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR011527"
FT /db_xref="InterPro:IPR017871"
FT /db_xref="InterPro:IPR017940"
FT /db_xref="UniProtKB/Swiss-Prot:P63393"
FT /protein_id="CAA99982.1"
FT /translation="MIRTWIALVPNDHRARLIGFALLAFCSVVARAVGTVLLVPLMAAL
FT FGEAPQRAWLWLGWLSAATVAGWVLDAVTARIGIELGFAVLNHTQHDVADRLPVVRLDW
FT FTAENTATARQAIAATGPELVGLVVNLVTPLTSAILLPAVIALALLPISWQLGVAALAG
FT VPLLLGALWASAAFARRADTAADKANTALTERIIEFARTQQALRAARRVEPARSLVGNA
FT LASQHTATMRLLGMQIPGQLLFSIASQLALIVLAGTTAALTITGTLTVPEAIALIVVMV
FT RYLEPFTAVSELAPALESTRATLGRIGSVLTAPVMVAGSGTWRDGAVVPRIEFDDVAFG
FT YDGGSGPVLDGVSFCLQPGTTTAIVGPSGCGKSTILALIAGLHQPTRGRVLIDGTDVAT
FT LDARAQQAVCSVVFQHPYLFHGTIRDNVFAADPGASDDQFAQAVRLARVDELIARLPDG
FT ANTIVGEAGSALSGGERQRVSIARALLKAAPVLLVDEATSALDAENEAAVVDALAADPR
FT SRTRVIVAHRLASIRHADRVLFVDDGRVVEDGSISELLTAGGRFSQFWRQQHEAAEWQI
FT LAE"
FT misc_feature 133675..133698
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature 133987..134031
FT /note="PS00211 ABC transporters family signature"
FT CDS 134448..135191
FT /transl_table=11
FT /gene="fabG2"
FT /locus_tag="Rv1350"
FT /product="PROBABLE 3-OXOACYL-[ACYL-CARRIER PROTEIN]
FT REDUCTASE FABG2 (3-KETOACYL-ACYL CARRIER PROTEIN
FT REDUCTASE)"
FT /function="INVOLVED IN THE FATTY ACID BIOSYNTHESIS PATHWAY
FT (FIRST REDUCTION STEP) [CATALYTIC ACTIVITY:
FT (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ =
FT 3-oxoacyl-[acyl-carrier protein] + NADPH]."
FT /EC_number="1.1.1.100"
FT /note="Rv1350, (MTCY02B10.14), len: 247 aa. Probable fabG2,
FT 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100),
FT highly similar to many e.g. NP_350157.1|NC_003030
FT 3-ketoacyl-acyl carrier protein reductase from Clostridium
FT acetobutylicum (249 aa); NP_229523.1|NC_000853
FT 3-oxoacyl-(acyl carrier protein) reductase from Thermotoga
FT maritima (246 aa); AAC44307.1|U59433 3-ketoacyl-acyl
FT carrier protein reductase from Bacillus subtilis (246 aa);
FT etc. Contains PS00061 Short-chain dehydrogenases/reductases
FT family signature. BELONGS TO THE SHORT-CHAIN
FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY."
FT /db_xref="GOA:P66781"
FT /db_xref="InterPro:IPR002198"
FT /db_xref="InterPro:IPR002347"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="UniProtKB/Swiss-Prot:P66781"
FT /protein_id="CAA99983.1"
FT /translation="MASLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEATE
FT VAAKRLGGDDVALAVRCDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDATMRTMTE
FT EQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAAKAGIV
FT GMTKAAAKELAHLGIRVNAIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASV
FT AVFLASDLSSYMTGTVLDVTGGRFI"
FT misc_feature 134871..134957
FT /note="PS00061 Short-chain alcohol dehydrogenase family
FT signature"
FT CDS 135188..135517
FT /transl_table=11
FT /locus_tag="Rv1351"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1351, (MTCY02B10.15), len: 109 aa. Hypothetical
FT unknown protein."
FT /db_xref="UniProtKB/Swiss-Prot:P64821"
FT /protein_id="CAA99984.1"
FT /translation="MTPRSLPRYGNSSRRKSFPMHRPSNVATATRKKSSIGWVLLACSV
FT AGCKGIDTTEFILGRAGAFELAVRAAQHRHRYLTMVNVGRAPPRRCRTVCMAATDTPRN
FT IRLNG"
FT CDS 135720..136091
FT /transl_table=11
FT /locus_tag="Rv1352"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1352, (MTCY02B10.16), len: 123 aa. Conserved
FT hypothetical protein, some similarity to Rv1906c|MTCY180.12
FT hypothetical protein from Mycobacterium tuberculosis (156
FT aa), FASTA scores: E(): 4e-05, (36.2% identity in 116 aa
FT overlap)."
FT /db_xref="UniProtKB/Swiss-Prot:P64823"
FT /protein_id="CAA99985.1"
FT /translation="MARTLALRASAGLVAGMAMAAITLAPGARAETGEQFPGDGVFLVG
FT TDIAPGTYRTEGPSNPLILVFGRVSELSTCSWSTHSAPEVSNENIVDTNTSMGPMSVVI
FT PPTVAAFQTHNCKLWMRIS"
FT CDS complement(136157..136942)
FT /transl_table=11
FT /locus_tag="Rv1353c"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1353c, (MTCY02B10.17c), len: 261 aa. Probable
FT transcriptional regulatory protein, similar to
FT TER1_ECOLI|P03038 tetracycline repressor protein class A
FT from Escherichia coli (216 aa), FASTA scores, opt: 231,
FT E(): 1.6e-08, (31.3% identity in 211 aa overlap). Helix
FT turn helix motif present at aa 3859 (+3.59 SD). BELONGS TO
FT THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS."
FT /db_xref="GOA:P67434"
FT /db_xref="InterPro:IPR001647"
FT /db_xref="InterPro:IPR004111"
FT /db_xref="InterPro:IPR009057"
FT /db_xref="InterPro:IPR011075"
FT /db_xref="InterPro:IPR012287"
FT /db_xref="InterPro:IPR015893"
FT /db_xref="UniProtKB/Swiss-Prot:P67434"
FT /protein_id="CAA99986.1"
FT /translation="MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGKH
FT LGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFAD
FT NPVLCDLILIRAALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVV
FT LDRLSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILD
FT HAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR"
FT CDS complement(136962..138833)
FT /transl_table=11
FT /locus_tag="Rv1354c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1354c, (MTCY02B10.18c), len: 623 aa. Conserved
FT hypothetical protein, similar to many hypothetical proteins
FT e.g. the C-terminus of G1001455 Synechocystis sp. (1244
FT aa), FASTA scores: opt: 933, E(): 0, (36.8% identity in 462
FT aa overlap); also similar to Rv1357c|MTCY02B10.21c (34.0%
FT identity in 253 aa overlap)."
FT /db_xref="InterPro:IPR000160"
FT /db_xref="InterPro:IPR001633"
FT /db_xref="InterPro:IPR003018"
FT /db_xref="UniProtKB/Swiss-Prot:P64825"
FT /protein_id="CAA99987.1"
FT /translation="MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLG
FT VDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEPLVFR
FT PEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTI
FT ATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALFLDLD
FT RLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPL
FT AERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSV
FT AIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTR
FT GLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTG
FT GFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGY
FT SAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAA
FT RILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS"
FT CDS complement(138842..140989)
FT /transl_table=11
FT /gene="moeY"
FT /locus_tag="Rv1355c"
FT /product="POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY"
FT /function="INVOLVED IN BIOSYNTHESIS OF A DEMOLYBDO COFACTOR
FT (MOLYBDOPTERIN), NECESSARY FOR MOLYBDOENZYMES. PLAYS A ROLE
FT IN THE ACTIVATION OF THE SMALL SUBUNIT OF THE MOLYBDOPTERIN
FT CONVERTING FACTOR (MOAD)"
FT /note="Rv1355c, (MTCY02B10.19c), len: 715 aa. Possible
FT moeY, Molybdopterin biosynthesis protein, very weak
FT similarity to MOEB_ECOLI|P12282 molybdopterin biosynthesis
FT moeb protein (249 aa), FASTA scores, opt: 180, E():
FT 8.5e-05, (29.3% identity in 174 aa overlap)."
FT /db_xref="GOA:Q11025"
FT /db_xref="InterPro:IPR000594"
FT /db_xref="InterPro:IPR009036"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="UniProtKB/Swiss-Prot:Q11025"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA99988.1"
FT /translation="MTIPHEGGSTGILVLRDDDHDDVLVLDRLRSDPSIEFVDRFAEQL
FT AGVRRLLPQPDPDLLEEAKRWAYYPWRRMVVAILGLRGFRAVRLDRNRHLITAEEQRAL
FT HALRVGVVGLSAGHAIAYTLAAEGACGTLRLADFDKIELSNLNRVPVGVFDIGLNKAMI
FT AARRIAELDPYLAVDLVTSGLSPESVDEFLDGLDVVIEECDSLDIKVILRQAACARGVP
FT VLMATSDRGLVDVERYDVEPGRPIFHGLLGDIDADKLCGLTTKDKVPHVLNILDCQELS
FT ARCAASMIEVDQTLWGWPQLAGDIWVGAATVAEAVRRIGLGEPLESGRVRVDVSAALDR
FT LDQPPMPSRGNGWLLESVPPTAPAEPQPTSEIVAQAAIRAPSGGNVQPWHVVAKQHSLT
FT IRLAPEHTSAMDIAFRGSAVAVGAAMFNARVAAAAHRVLGSVEFDESQPDSPLQATMHF
FT GRGDDPSLAALYRPMLLRTTNRHHGMPGHVHPATVELLTNTAAAEGARLQLLLSRNEID
FT RAATILAAADRIRYLTPRLHEEMMSELRWPGDPSLDAGIDVRSLELDSGELRVLDILRR
FT SDVVARLAQWDCGTALEDNTNERVSASSALAIVYVDGATLTDFARGGSAMQAVWIVAQQ
FT HGLAVQPMSPIFLYARGRHDLDQASPHFAAQLHRLQLDFRELVKPGKEGHEVLIFRLFH
FT APPPSVCSRRRVRHAIPEPHR"
FT CDS complement(140986..141777)
FT /transl_table=11
FT /locus_tag="Rv1356c"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1356c, (MTCY02B10.20c), len: 263 aa. Hypothetical
FT unknown protein."
FT /db_xref="UniProtKB/Swiss-Prot:P64827"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA99989.1"
FT /translation="MLIAGYLTDWRIMTTAQLRPIAPQKLHFSENLSVWVSDAQCRLVV
FT SQPALDPTLWNTYLQGALRAYSKHGVECTLDLDAISDGSDTQLFFAAIDIGGDVVGGAR
FT VIGPLRSADDSHAVVEWAGNPGLSAVRKMINDRAPFGVVEVKSGWVNSDAQRSDAIAAA
FT LARALPLSMSLLGVQFVMGTAAAHALDRWRSSGGVIAARIPAAAYPDERYRTKMIWWDR
FT RTLANHAEPKQLSRMLVESRKLLRDVEALSATTAATAGAEQ"
FT CDS complement(142250..143173)
FT /transl_table=11
FT /locus_tag="Rv1357c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1357c, (MTCY02B10.21c), len: 307 aa. Conserved
FT hypothetical protein, similar to members of the
FT YEGE/YHJK/YJCC family e.g. Y4LL_RHISN|P55552 hypothetical
FT protein Y4ll from Rhizobium sp. (827 aa), FASTA scores:
FT E(): 0, (37.7% identity in 257 aa overlap), also similar to
FT Rv1354c|MTCY02B10.18c (34.0% identity in 253 aa overlap).
FT BELONGS TO THE YEGE/YHDA/YHJK/YJCC FAMILY."
FT /db_xref="GOA:P64829"
FT /db_xref="InterPro:IPR001633"
FT /db_xref="UniProtKB/Swiss-Prot:P64829"
FT /protein_id="CAA99962.1"
FT /translation="MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWAD
FT SDRDQVNTRHYLSTSMRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTLLP
FT GRFIDRAENNGLMVPLTAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVL
FT VEGVLGETGLPAHALQLELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAY
FT LPRLPVDVVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQAA
FT RLRAFGCKAAQGWHFAKALPVDFFRE"
FT CDS 143569..147048
FT /transl_table=11
FT /locus_tag="Rv1358"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1358, (MTCY02B10.22), len: 1159 aa. Probable
FT transcriptional regulatory protein, some similarity to
FT AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces
FT coelicolor (993 aa), FASTA scores: opt: 210, E(): 5.5e-06,
FT (27.5% identity in 739 aa overlap). Similar also to
FT Rv0890C|MTCY31.18c (65.5% identity in 884 aa overlap) and
FT to Rv1359|MTCY02B10.23 (43.7% identity in 197 aa overlap).
FT Contains PS00017 ATP/GTP-binding site motif A, PS00622
FT Bacterial regulatory proteins, luxR family signature. Helix
FT turn helix motif present at aa 1116-1137, (Score 1291,
FT +3.59 SD)."
FT /db_xref="GOA:Q11028"
FT /db_xref="HSSP:1FSE"
FT /db_xref="InterPro:IPR000792"
FT /db_xref="InterPro:IPR001054"
FT /db_xref="InterPro:IPR011991"
FT /db_xref="InterPro:IPR016032"
FT /db_xref="UniProtKB/TrEMBL:Q11028"
FT /protein_id="CAA99963.1"
FT /translation="MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQ
FT IARTGHMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTRLNEL
FT AADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIACALELQLSTLAPMR
FT PRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDLVIDQLPANTWLT
FT DVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEVQ
FT EVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALG
FT LIDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSRES
FT IGVTGEVTWVVPSLSPANEAIQLFTERARLVQPNFEIVADNFDAVSEICRRLDGMPLAI
FT ELAAARLRSLSPNEIANSLDDRFRLLTGGARSTVQRQQTLRASMDWSYALLTDTERILF
FT RRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLL
FT ETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEIDNLRA
FT AFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDNHLVPAGVWARAL
FT AEKVILKAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVACGCGSGCDTEAAQ
FT PYFAEAIELARAINDEWTLSQIDYWQVVGIFISGQPIPLRAAAEQARELADSIGNRFVS
FT RQCRLFACLAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIGDSAA
FT RTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAIEASEASWDLRNQHNVVTAHH
FT ELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARVAIAQDELGKARDDAHAA
FT VACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGY
FT EAATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKI
FT VKLVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST"
FT misc_feature 144448..144471
FT /note="PS00017 ATP/GTP-binding site motif A"
FT misc_feature 146908..146991
FT /note="PS00622 Bacterial regulatory proteins, luxR family
FT signature"
FT CDS 147130..147882
FT /transl_table=11
FT /locus_tag="Rv1359"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1359, (MTCY02B10.23), len: 250 aa. Probable
FT transcriptional regulatory protein, similar to
FT Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and
FT to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap)."
FT /db_xref="GOA:Q11029"
FT /db_xref="InterPro:IPR001054"
FT /db_xref="UniProtKB/Swiss-Prot:Q11029"
FT /protein_id="CAA99964.1"
FT /translation="MFMALRAPMLERMNGLHTDDAPVNWLERRGGRLTSRRRVTLLHAG
FT VEHPMRLWGVQSEAITAAMVLSRKVSAIIAGHCGVRLVDQGVGDGFVAAFAHASDAVAC
FT ALELHQAPLSPIVLRIGIHTGEAQLVDERIYAGATMNLAAELRDLAHGGQTVMSGATED
FT AVLGRLPMRAWLIGLRPMEGSPEGHNFPQSQRIAQLCHPNLRNTFPPLRMRIADASGIP
FT YVGRILVNVQVVPHWEGGCAAAGMVLAG"
FT CDS 148305..149327
FT /transl_table=11
FT /locus_tag="Rv1360"
FT /product="PROBABLE OXIDOREDUCTASE"
FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT METABOLISM."
FT /EC_number="1.-.-.-"
FT /note="Rv1360, (MTCY02B10.24), len: 340 aa. Probable
FT oxidoreductase (EC 1.-.-.-). Similar to Q49598|G1002714
FT coenzyme F420-dependent n5,
FT n10-methylenetetrahydromethanopterin reductase from
FT Methanopyrus kandleri (349 aa), FASTA scores: opt: 264,
FT E(): 4.4e-11, (26.3% identity in 323 aa overlap)."
FT /db_xref="InterPro:IPR011251"
FT /db_xref="InterPro:IPR019919"
FT /db_xref="UniProtKB/Swiss-Prot:P64831"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA99965.1"
FT /translation="MGGARRLKLDGSIPNQLARAADAAVALERNGFDGGWTAEASHDPF
FT LPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWDLQTYSKGRLILGLGTQIRPHIEK
FT RFSMPWGHPARRMREFVAALRAIWLAWQDGTKLCFEGEFYTHKIMTPMFTPEPQPYPVP
FT RVFIAAVGEAMTEMCGEVADGHLGHPMVSKRYLTEVSVPALLRGLARSGRDRSAFEVSC
FT EVMVATGADDAELAAACTATRKQIAFYGSTPAYRKVLEQHGWGDLHPELHRLSKLGEWE
FT AMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDRVLPIFMAASQECINAALQDFRR
FT "
FT CDS complement(149400..150590)
FT /transl_table=11
FT /gene="PPE19"
FT /locus_tag="Rv1361c"
FT /standard_name="mtb39b"
FT /product="PPE FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1361c, (MTCY02B10.25c), len: 396 aa. PPE19
FT (alternate gene name: mtb39b). Member of the Mycobacterium
FT tuberculosis PPE family of glycine-rich proteins, highly
FT similar to many e.g. Rv1196|MTCI364.08|PPE18, FASTA scores:
FT E(): 0, (84.9% identity in 397 aa overlap); MTCY274.23c
FT (42.3% identity in 416 aa overlap); etc. Contains PS00501
FT Signal peptidases I serine active site. Note that
FT expression of Rv1361c was demonstrated in lysates by
FT immunodetection (see Dillon et al., 1999)."
FT /db_xref="InterPro:IPR000030"
FT /db_xref="UniProtKB/Swiss-Prot:Q11031"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55379.1"
FT /translation="MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAASA
FT FQSVVWGLTTGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGL
FT TVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATAT
FT EALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFD
FT QLSELWKAISPHLSPLSNIVSMLNNHVSMTNSGVSMASTLHSMLKGFAPAAAQAVETAA
FT QNGVQAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARA
FT LPLTSLTSAAQTAPGHMLGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG"
FT misc_feature complement(149805..149828)
FT /note="PS00501 Signal peptidases I serine active site"
FT CDS complement(150905..151567)
FT /transl_table=11
FT /locus_tag="Rv1362c"
FT /product="POSSIBLE MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1362c, (MTCY02B10.26c), len: 220 aa. Possible
FT membrane protein, similar to Mycobacterium tuberculosis
FT hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9%
FT identity in 216 aa overlap), Rv0177, Rv1973, Rv1972, etc."
FT /db_xref="GOA:Q11032"
FT /db_xref="UniProtKB/Swiss-Prot:Q11032"
FT /protein_id="CAA99967.1"
FT /translation="MTDDVRDVNTETTDATEVAEIDSAAGEAGDSATEAFDTDSATEST
FT AQKGQRHRDLWRMQVTLKPVPVILILLMLISGGATGWLYLEQYRPDQQTDSGAARAAVA
FT AASDGTIALLSYSPDTLDQDFATARSHLAGDFLSYYDQFTQQIVAPAAKQKSLKTTAKV
FT VRAAVSELHPDSAVVLVFVDQSTTSKDSPNPSMAASSVMVTLAKVDGNWLITKFTPV"
FT CDS complement(151564..152349)
FT /transl_table=11
FT /locus_tag="Rv1363c"
FT /product="POSSIBLE MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1363c, (MTCY02B10.27c), len: 261 aa. Possible
FT membrane protein, similar to Mycobacterium tuberculosis
FT hypothetical proteins Rv1362c|MTCY02B10.26c (25.9% identity
FT in 216 aa overlap ); Rv1972|MTV051.10 and Rv0177 etc."
FT /db_xref="GOA:Q11033"
FT /db_xref="UniProtKB/Swiss-Prot:Q11033"
FT /protein_id="CAA99968.1"
FT /translation="MAETTEPPSDAGTSQADAMALAAEAEAAEAEALAAAARARARAAR
FT LKREALAMAPAEDENVPEEYADWEDAEDYDDYDDYEAADQEAARSASWRRRLRVRLPRL
FT STIAMAAAVVIICGFTGLSGYIVWQHHEATERQQRAAAFAAGAKQGVINMTSLDFNKAK
FT EDVARVIDSSTGEFRDDFQQRAADFTKVVEQSKVVTEGTVNATAVESMNEHSAVVLVAA
FT TSRVTNSAGAKDEPRAWRLKVTVTEEGGQYKMSKVEFVP"
FT CDS complement(152640..154601)
FT /transl_table=11
FT /locus_tag="Rv1364c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1364c, (MTCY02B10.28c), len: 653 aa. Conserved
FT hypothetical protein, some similarity to RSBU_BACSU|P40399
FT sigma factor sibg regulation protein from Bacillus subtilis
FT (335 aa), FASTA scores: opt: 224, E(): 2e-07, (25.8%
FT identity in 244 aa overlap)."
FT /db_xref="GOA:Q11034"
FT /db_xref="InterPro:IPR000014"
FT /db_xref="InterPro:IPR000700"
FT /db_xref="InterPro:IPR001610"
FT /db_xref="InterPro:IPR001932"
FT /db_xref="InterPro:IPR002645"
FT /db_xref="InterPro:IPR003594"
FT /db_xref="InterPro:IPR010822"
FT /db_xref="InterPro:IPR013656"
FT /db_xref="UniProtKB/Swiss-Prot:Q11034"
FT /protein_id="CAE55380.1"
FT /translation="MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAY
FT RGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEER
FT YFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQ
FT ALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAV
FT MSQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGH
FT PPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEA
FT STAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAP
FT TPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDV
FT SKGIVVAAALAGDGNVRASVIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGT
FT TATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQ
FT IAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLS
FT LVQLPVVGADTEDIFAQE"
FT CDS complement(154740..155126)
FT /transl_table=11
FT /gene="rsfA"
FT /locus_tag="Rv1365c"
FT /product="ANTI-ANTI-SIGMA FACTOR RSFA (ANTI-SIGMA FACTOR
FT ANTAGONIST) (REGULATOR OF SIGMA F A)"
FT /function="REGULATES NEGATIVELY Rv3287c|RSBW|USFX.
FT REGULATED BY REDOX POTENTIAL."
FT /note="Rv1365c, (MTCY02B10.29c), len: 128 aa. rsfA,
FT anti-anti-sigma factor (see citation below), similar to
FT other Mycobacterium tuberculosis proteins e.g.
FT Rv2638|MTCY441.08 (148 aa), FASTA scores: E(): 0, (53.6%
FT identity in 125 aa overlap); Rv1904, Rv3687c. Weak
FT similarity to putative anti-anti-sigma factors e.g.
FT AF134889|AF134889_1 Streptomyces coelicolor (113 aa), FASTA
FT scores: opt: 137, E(): 0.004, (26.0% identity in 100 aa
FT overlap)."
FT /db_xref="GOA:Q11035"
FT /db_xref="InterPro:IPR002645"
FT /db_xref="InterPro:IPR003658"
FT /db_xref="UniProtKB/Swiss-Prot:Q11035"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA99970.1"
FT /translation="MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTWQ
FT DLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHEAERCRRRGVDVRLVSRDRAVAR
FT IIHACGYGDVLPVHPTTESALSAT"
FT CDS 155347..156168
FT /transl_table=11
FT /locus_tag="Rv1366"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1366, (MTCY02B10.30), len: 273 aa. Hypothetical
FT unknown protein."
FT /db_xref="GOA:P64833"
FT /db_xref="InterPro:IPR007685"
FT /db_xref="UniProtKB/Swiss-Prot:P64833"
FT /protein_id="CAA99971.1"
FT /translation="MVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYA
FT EVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKSQDTLLAKLRRRPYLQLNTIQDIAG
FT VRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVEIQI
FT RTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHE
FT AEWQHCAEIEYPGQRAMALGEASKNKATVLATTKFRLERAINEAESAGGGG"
FT CDS complement(156469..157602)
FT /transl_table=11
FT /locus_tag="Rv1367c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN (POSSIBLY INVOLVED IN CELL WALL
FT BIOSYNTHESIS)."
FT /note="Rv1367c, (MTCY02B12.01c,MTCY02B10.31c), len: 377 aa.
FT Conserved hypothetical protein. Some similarity to
FT penicillin binding proteins e.g. PBPE_BACSU|P32959
FT penicillin-binding protein 4* (pbp 4*) from Bacillus
FT subtilis (451 aa), FASTA scores: E(): 6.9e-06, (23.6%
FT identity in 373 aa overlap). Similar to AL031107|SC5A7.06
FT hypothetical protein from Streptomyces coelicolor (409 aa),
FT FASTA scores: opt: 675, E(): 0, (40.4% identity in 339 aa
FT overlap)."
FT /db_xref="InterPro:IPR001466"
FT /db_xref="InterPro:IPR012338"
FT /db_xref="UniProtKB/Swiss-Prot:Q11037"
FT /protein_id="CAB02645.1"
FT /translation="MVWQREKLLQVNEIGYRDIDAGVPMQRDTLFRIASMTKPVTVAAA
FT MSLVDEGKLALRDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAY
FT GFSVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYSHAIDVLGVIVSRIED
FT APLYQIIDERVLGPAGMTDTGFYVSADAQRRAATMYRLDEQDRLRHDVMGPPHVTPPSF
FT CNAGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHSFLGAP
FT FWVGRGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLYLIQHC
FT PDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL"
FT CDS 157977..158762
FT /transl_table=11
FT /gene="lprF"
FT /locus_tag="Rv1368"
FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRF"
FT /function="UNKNOWN"
FT /note="Rv1368, (MTCY02B12.02), len: 261 aa. Probable lprF,
FT conserved lipoprotein; similar to Mycobacterium
FT tuberculosis hypothetical lipoproteins e.g.
FT Rv1270c|Y08C_MYCTU|Q11049 hypothetical 26.4 kDa protein
FT cy50.12. (257 aa), FASTA scores: opt: 286, E(): 5.3e-11,
FT (26.3% identity in 270 aa overlap), also
FT Rv1411c|MTCY21B4.28c, (32.8% identity in 253 aa overlap)
FT and Rv2945c. Contains possible N-terminal signal sequence
FT and appropriately positioned prokaryotic lipoprotein lipid
FT attachment site (PS00013). BELONGS TO THE LPPX/LPRAFG
FT FAMILY OF LIPOPROTEINS."
FT /db_xref="GOA:P65314"
FT /db_xref="InterPro:IPR009830"
FT /db_xref="UniProtKB/Swiss-Prot:P65314"
FT /protein_id="CAB02646.1"
FT /translation="MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTT
FT ASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNG
FT QAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLG
FT AVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNA
FT STPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG"
FT repeat_region 158906..158908
FT /note="3 bp direct repeat, CGG, at 3' end of IS6110 target
FT sequence"
FT repeat_region complement(158909..160263)
FT /mobile_element="insertion sequence:IS6110-2"
FT /note="IS6110-2, len: 1355 bp. Almost identical to
FT Insertion sequence IS986 element."
FT CDS complement(158951..159835)
FT /transl_table=11
FT /locus_tag="Rv1369c"
FT /product="PROBABLE TRANSPOSASE"
FT /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE
FT INSERTION ELEMENT IS6110."
FT /note="Rv1369c, (MTCY02B12.03c), len: 294 aa. Probable
FT transposase subunit for IS6110, identical from aa 69 to
FT TRA9_MYCTU|P19774 putative transposase for insertion
FT sequence."
FT /db_xref="GOA:P0C5G8"
FT /db_xref="InterPro:IPR001584"
FT /db_xref="InterPro:IPR012337"
FT /db_xref="UniProtKB/Swiss-Prot:P0C5G8"
FT /protein_id="CAB02647.1"
FT /translation="MRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEH
FT ISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPA
FT TARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMAT
FT SMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSS
FT YDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELE
FT AAYYAQRQRPAAG"
FT CDS complement(159886..160212)
FT /transl_table=11
FT /locus_tag="Rv1370c"
FT /product="PROBABLE TRANSPOSASE"
FT /function="POSSIBLY REQUIRED FOR THE TRANSPOSITION OF THE
FT INSERTION ELEMENT IS6110."
FT /note="Rv1370c, (MTCY02B12.04c), len: 108 aa. Probable
FT transposase subunit for IS6110, highly similar to G309867
FT IS401 transposase subunit (107 aa), FASTA scores: opt: 325,
FT E(): 2.7e-1 6, (52.9% identity in 102 aa overlap)."
FT /db_xref="GOA:P0C5G9"
FT /db_xref="InterPro:IPR002514"
FT /db_xref="UniProtKB/Swiss-Prot:P0C5G9"
FT /protein_id="CAB02648.1"
FT /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG
FT CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD
FT RPAR"
FT repeat_region 160264..160266
FT /note="3 bp direct repeat, CGG, at 5' end of IS6110 target
FT sequence"
FT CDS 160316..161785
FT /transl_table=11
FT /locus_tag="Rv1371"
FT /product="PROBABLE CONSERVED MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1371, (MTCY02B12.05), len: 489 aa. Probable
FT membrane protein. Weak similarity to delta 5 fatty acid
FT desaturases e.g. AB022097|AB022097_1 Dictyostelium
FT discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052,
FT (22.4% identity in 438 aa overlap); and Homo sapiens."
FT /db_xref="GOA:P71799"
FT /db_xref="HSSP:1ICC"
FT /db_xref="InterPro:IPR001199"
FT /db_xref="InterPro:IPR005804"
FT /db_xref="UniProtKB/TrEMBL:P71799"
FT /protein_id="CAB02649.1"
FT /translation="MTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWISK
FT HPGGAFFIGRTKNRDITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPAFL
FT FKDDFNSWRDTPKYRFDDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVGYFA
FT VQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNYVALS
FT LVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMAIRIVD
FT VFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQFVATLW
FT VSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVIGNRYVDCFLSAGLSSHRVH
FT HVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDRLPRLCRKYLLTPSRQAKER
FT HWGFVREHCSPAALKASASYVVAGFVGIGSV"
FT CDS 161782..162963
FT /transl_table=11
FT /locus_tag="Rv1372"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1372, (MTCY02B12.06), len: 393 aa. Conserved
FT hypothetical protein, similar to several chalcone synthases
FT e.g. CHS2_GERHY|P48391 chalcone synthase 2 from gerbra
FT hybrid (402 aa), FASTA scores: opt: 511, E(): 7e-26, (28.4%
FT identity in 380 aa overlap). Also similar to Mycobacterium
FT tuberculosis hypothetical chalcone synthases, Rv1665,
FT Rv1660."
FT /db_xref="GOA:Q7D8I1"
FT /db_xref="InterPro:IPR001099"
FT /db_xref="InterPro:IPR011141"
FT /db_xref="InterPro:IPR012328"
FT /db_xref="InterPro:IPR016038"
FT /db_xref="InterPro:IPR016039"
FT /db_xref="PDB:1TED"
FT /db_xref="PDB:1TEE"
FT /db_xref="UniProtKB/TrEMBL:Q7D8I1"
FT /protein_id="CAE55381.1"
FT /translation="MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRR
FT VVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRD
FT RMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSP
FT SISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHS
FT LFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENL
FT PGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDV
FT LARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR"
FT CDS 162969..163949
FT /transl_table=11
FT /locus_tag="Rv1373"
FT /product="GLYCOLIPID SULFOTRANSFERASE"
FT /function="INVOLVED IN SULFATION: ACTIVITY TOWARDS TYPICAL
FT CERAMIDE GLYCOLIPIDS AND TREHALOSE GLYCOLIPIDS."
FT /EC_number="2.8.2.-"
FT /note="Rv1373, (MTCY02B12.07), len: 326 aa. Glycolipid
FT sulfotransferase (EC 2.8.2.-) (see citation below); slight
FT similarity to sulfotransferases e.g. SUOE_CAVPO|P49887
FT estrogen sulfotransferase from Cavia porcellus (Guinea pig)
FT (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054,
FT (24.5% identity in 294 aa overlap)."
FT /db_xref="GOA:P71801"
FT /db_xref="InterPro:IPR000863"
FT /db_xref="UniProtKB/Swiss-Prot:P71801"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02651.1"
FT /translation="MNSEHPMTDRVVYRSLMADNLRWDALQLRDGDIIISAPSKSGLTW
FT TQRLVSLLVFDGPDLPGPLSTVSPWLDQTIRPIEEVVATLDAQQHRRFIKTHTPLDGLV
FT LDDRVSYICVGRDPRDAAVSMLYQSANMNEDRMRILHEAVVPFHERIAPPFAELGHARS
FT PTEEFRDWMEGPNQPPPGIGFTHLKGIGTLANILHQLGTVWVRRHLPNVALFHYADYQA
FT DLAGELLRPARVLGIAATRDRARDLAQYATLDAMRSRASEIAPNTTDGIWHSDERFFRR
FT GGSGDWQQFFTEAEHLRYYHRINQLAPPDLLAWAHEGRRGYDPAN"
FT CDS complement(164029..164487)
FT /transl_table=11
FT /locus_tag="Rv1374c"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1374c, (MTCY02B12.08c), len: 152 aa. Hypothetical
FT unknown protein."
FT /db_xref="UniProtKB/TrEMBL:P71802"
FT /protein_id="CAB02652.2"
FT /translation="MVTSVADENVASRIASWGTGPAPDPRLDYAHAHLKGRRGRSPARP
FT NAPIGARSFAVGRKICRVERFTLLEHGFVGHALHRVPCAGLVALVMSACSLAVCREVGN
FT YAQRRVGRFAFFEQTFVRHALTPRCSRTDSKTSYTQLNRICKFPPHWV"
FT CDS 164789..166108
FT /transl_table=11
FT /locus_tag="Rv1375"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1375, (MTCY02B12.09), len: 439 aa. Conserved
FT hypothetical protein, similar to hypothetical proteins from
FT several organisms e.g. Q52871|U39409 Rhizobium
FT leguminosarum (420 aa), FASTA scores: E(): 2e-30, (34.4%
FT identity in 378 aa overlap)."
FT /db_xref="InterPro:IPR003776"
FT /db_xref="UniProtKB/Swiss-Prot:P71803"
FT /protein_id="CAB02636.1"
FT /translation="MTGRRLARFPAFRAGVAQDDDVGSTLSQGSTTGVLSGPNWSYWPS
FT RVLGSADPTTIAHRHGTHRITSPDETWLALQPFLAPAGITGVADVTWLDCLGIPTVQAV
FT RPASLTLSVSQGKAASYRAAQVSAVMESLEGWHAENVTADLWSATARDLEADLTYDPAQ
FT LRHRPGSLYHAGVKLDWMVATTLLTGRRTWVPWTAVLVNVATRDCWEPPMFEMDTTGLA
FT SGNCYDEATLHALYEVMERHSVAAAVAGETMFEVPTDDVAGSDSAHLVEMIRDAGDDVD
FT LARIDVWDGYYCFAAELTSATLEVTFGGFGLHHDPNVALSRAITEAAQSRITAISGARE
FT DLPSAIYHRFGRVHTYAKARKTSLRLNRARPTPWRVPDVDSLPELVASAATAVANRSGT
FT EPLAVVCDFADACVPVVKVLAPGLVLSSASPMRTPLQEAE"
FT CDS 166105..167598
FT /transl_table=11
FT /locus_tag="Rv1376"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1376, (MTCY02B12.10), len: 497 aa. Conserved
FT hypothetical protein, some similarity to hypothetical
FT proteins from several organisms e.g. Q52872|U39409
FT Rhizobium leguminosarum (247 aa), FASTA scores: E():
FT 2.1e-12, (34.7% identity in 219 aa overlap)."
FT /db_xref="InterPro:IPR012924"
FT /db_xref="InterPro:IPR016845"
FT /db_xref="UniProtKB/TrEMBL:P71804"
FT /protein_id="CAB02637.1"
FT /translation="MTACGRIVVTAGPTISAADIRSVVPDAEVAPPIAFGQALSYDLRS
FT GDTLLIVDGLFFQQPSVRHKELLTLMADGVRVVGSSSMGALRAAELHPFGMEGYGWVFE
FT SYRDGVLEADDEVGVVHGDADDGYPVFVDALVNMRHTLARAVATGVVCSELAERIIETA
FT RATPFTMRTWARLLSEVGAPDQRGLAAQLRSLRVDVKHADALLALRQLGQRPRVEPLRP
FT GPPPTVWSRRWRQRWAPPTSVAASADHGESFVDVTDLEVLSFLSVSSVDYWAYRPALQQ
FT VAAWYWTLKHPEQSGSVGERAARAVAEVASEGYGRALEFIAYRYALATGIIDETGFPEA
FT VAAHWLTTEERHGLGNDPISISARVITRTLFVVRLLPAIDHFLDLLRKDSRLPRWRAMA
FT AHALCKRDDLARQKPHLNLGRPDPTQLKRLFGARWGTQVNRIELARRGLMTEDAFYAAA
FT TPFAVAAVDDQLPRIEVGTLGPAPLSADVPERHFDFGSV"
FT CDS complement(167536..168174)
FT /transl_table=11
FT /locus_tag="Rv1377c"
FT /product="PUTATIVE TRANSFERASE"
FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT METABOLISM"
FT /EC_number="2.-.-.-"
FT /note="Rv1377c, (MTCY02B12.11c), len: 212 aa. Putative
FT transferase (EC 2.-.-.-), similar to YQEM_BACSU|P54458
FT hypothetical 28.3 kDa protein from Bacillus subtilis (247
FT aa), FASTA scores: opt: 221, E(): 7.6e-08, (30.6% identity
FT in 144 aa overlap); some similarity to methyltransferases,
FT also similar to Mycobacterium tuberculosis hypothetical
FT proteins Rv0560c, Rv3699, and Rv2675c (~ 39.1% identity in
FT 197 aa overlap)."
FT /db_xref="GOA:P71805"
FT /db_xref="HSSP:1UFK"
FT /db_xref="InterPro:IPR013216"
FT /db_xref="UniProtKB/TrEMBL:P71805"
FT /protein_id="CAB02638.1"
FT /translation="MPGIDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTGGWV
FT HGDVLDIGCGLGDNAIYLARNGYQVTGLDISPTALTTAKRRASDAGVDVKFAVGDATKL
FT TGYTGAFDTVIDCGMFHCLDDDGKRSYAASVHRATRPGATLLLSCFSNAMPPDEEWPRS
FT TVSEQTLRDVLGGAGWDIESLEPATVRRELDGTEVEMAFWNVRAQRRGS"
FT CDS complement(168185..169612)
FT /transl_table=11
FT /locus_tag="Rv1378c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN. THOUGHT TO BE REGULATED BY
FT Rv2720|LEXA."
FT /note="Rv1378c, (MTCY02B12.12c), len: 475 aa. Conserved
FT hypothetical protein, similar to other Mycobacterium
FT tuberculosis hypothetical proteins e.g. Rv3074|MTCY22D7.07C
FT (424 aa), FASTA scores: E(): 0, (73.0% identity in 429 aa
FT overlap)."
FT /db_xref="InterPro:IPR003615"
FT /db_xref="UniProtKB/TrEMBL:P71806"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02639.1"
FT /translation="MGNLDLLLRLSGRIVKGCRPLGSVALARCGPAVRWPRWPRPAILE
FT HMFDLVSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEADAGVP
FT ARRRGRGVASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALEVGRLSEWRATLIVR
FT ESACLDVEDRRALDAELCADMSALDGMGDARIAAAARAIAYRLDAQAVVERAARAETER
FT TVTIRPAPDTMTWVTALLPVARGVSVYAALKRAADTTFDDRTRGQVMADTLVERVTGQP
FT AEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVADTRSRATLRRL
FT YRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMPYCDAPIRHRDHAQPHHRGGPTT
FT ATNGLGSCERCNYVKEAPGWRVSTDTDETGRHTAEFTTPTGMYYHCTAPPLPGPLEIDV
FT SQVEARIGVALTHLHAA"
FT CDS 169611..170192
FT /transl_table=11
FT /gene="pyrR"
FT /locus_tag="Rv1379"
FT /product="PROBABLE PYRIMIDINE OPERON REGULATORY PROTEIN
FT PYRR"
FT /function="BINDS TO THE CONSERVED SEQUENCE IN THE PYR
FT OPERON MRNA AND DISRUPTS THE ANTITERMINATOR, PERMITTING
FT TERMINATOR HAIRPIN FORMATION AND PROMOTING TRANSCRIPTION
FT TERMINATION"
FT /note="Rv1379, (MTCY02B12.13), len: 193 aa. Probable pyrR,
FT pyrimidine operon regulatory protein, similar to
FT PYRR_BACCL|P41007 pyrimidine operon regulatory protein from
FT Bacillus caldolyticus (179 aa), FASTA scores: opt: 544,
FT E(): 1.1e-30, (54.2% identity in 179 aa overlap)."
FT /db_xref="GOA:P65941"
FT /db_xref="InterPro:IPR000836"
FT /db_xref="PDB:1W30"
FT /db_xref="UniProtKB/Swiss-Prot:P65941"
FT /protein_id="CAB02640.1"
FT /translation="MGAAGDAAIGRESRELMSAADVGRTISRIAHQIIEKTALDDPVGP
FT DAPRVVLLGIPTRGVTLANRLAGNITEYSGIHVGHGALDITLYRDDLMIKPPRPLASTS
FT IPAGGIDDALVILVDDVLYSGRSVRSALDALRDVGRPRAVQLAVLVDRGHRELPLRADY
FT VGKNVPTSRSESVHVRLREHDGRDGVVISR"
FT CDS 170189..171148
FT /transl_table=11
FT /gene="pyrB"
FT /locus_tag="Rv1380"
FT /product="PROBABLE ASPARTATE CARBAMOYLTRANSFERASE PYRB
FT (ATCase) (Aspartate transcarbamylase)"
FT /function="INVOLVED IN PYRIMIDINE BIOSYNTHESIS (SECOND
FT STEP) [CATALYTIC ACTIVITY : CARBAMOYL PHOSPHATE +
FT L-ASPARTATE = PHOSPHATE + N-CARBAMOYL-L-ASPARTATE]"
FT /EC_number="2.1.3.2"
FT /note="Rv1380, (MTCY02B12.14), len: 319 aa. Probable pyrB,
FT aspartate carbamoyltransferase (EC 2.1.3.2), similar to
FT many e.g. PYRB_BACCL|P41008 aspartate carbamoyltransferase
FT from Bacillus caldolyticus (308 aa), FASTA scores, opt:
FT 639, E(): 7.3e-36, (39.5% identity in 311 aa overlap).
FT Contains PS00097 Aspartate and ornithine
FT carbamoyltransferases signature. BELONGS TO THE
FT ATCASES/OTCASES FAMILY."
FT /db_xref="GOA:P65613"
FT /db_xref="InterPro:IPR002082"
FT /db_xref="InterPro:IPR006130"
FT /db_xref="InterPro:IPR006131"
FT /db_xref="InterPro:IPR006132"
FT /db_xref="UniProtKB/Swiss-Prot:P65613"
FT /protein_id="CAB02641.1"
FT /translation="MTPRHLLTAADLSRDDATAILDDADRFAQALVGRDIKKLPTLRGR
FT TVVTMFYENSTRTRVSFEVAGKWMSADVINVSAAGSSVGKGESLRDTALTLRAAGADAL
FT IIRHPASGAAHLLAQWTGAHNDGPAVINAGDGTHEHPTQALLDALTIRQRLGGIEGRRI
FT VIVGDILHSRVARSNVMLLDTLGAEVVLVAPPTLLPVGVTGWPATVSHDFDAELPAADA
FT VLMLRVQAERMNGGFFPSVREYSVRYGLTERRQAMLPGHAVVLHPGPMVRGMEITSSVA
FT DSSQSAVLQQVSNGVQVRMAVLFHVLVGAQDAGKEGAA"
FT misc_feature 170339..170362
FT /note="PS00097 Aspartate and ornithine
FT carbamoyltransferases signature"
FT CDS 171145..172437
FT /transl_table=11
FT /gene="pyrC"
FT /locus_tag="Rv1381"
FT /product="PROBABLE DIHYDROOROTASE PYRC (DHOase)"
FT /function="INVOLVED IN PYRIMIDINE BIOSYNTHESIS (THIRD STEP)
FT [CATALYTIC ACTIVITY: (S)-DIHYDROOROTATE + H(2)O =
FT N-CARBAMOYL-L-ASPARTATE]"
FT /EC_number="3.5.2.3"
FT /note="Rv1381, (MTCY02B12.15), len: 430 aa. Probable pyrC,
FT dihydroorotase (EC 3.5.2.3), similar to many e.g.
FT PYRC_BACCL|P46538 (40.5% identity in 395 aa overlap).
FT Contains PS00483 Dihydroorotase signature 2. BELONGS TO THE
FT DHOASE FAMILY. SUBFAMILY 2."
FT /db_xref="GOA:P71809"
FT /db_xref="InterPro:IPR002195"
FT /db_xref="InterPro:IPR004722"
FT /db_xref="InterPro:IPR006680"
FT /db_xref="InterPro:IPR011059"
FT /db_xref="UniProtKB/Swiss-Prot:P71809"
FT /protein_id="CAB02642.1"
FT /translation="MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDAT
FT GHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDH
FT VWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRR
FT ALEYATGLGVLIAQHAEEPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLARD
FT AGARVHICHASAAGTVEILKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLR
FT EASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVA
FT PGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSA
FT NTPFESMSLPATVTATLLRGKVTARDGKIRA"
FT misc_feature 172048..172083
FT /note="PS00483 Dihydroorotase signature 2"
FT CDS 172434..172931
FT /transl_table=11
FT /locus_tag="Rv1382"
FT /product="PROBABLE EXPORT OR MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1382, (MTCY02B12.16), len: 165 aa. Possible
FT exported or membrane protein, hydrophobic domain at
FT N-terminus."
FT /db_xref="UniProtKB/TrEMBL:P71810"
FT /protein_id="CAB02643.1"
FT /translation="MNSGTLAGSLIFAAVLVMLIAVLARLMMRGWRRRSERQAELLGDL
FT PDVPEHVSSATVTTRGLYVGATLSPAWNERVTVGDLGYRSKAVLTRYPSGIMVERARAQ
FT PIWIPTESIAAIRMERGVAGKVVAGIGILAIRWRLPSGTEIDVGFRADNRDEYQEWLEE
FT PV"
FT CDS 172928..174058
FT /transl_table=11
FT /gene="carA"
FT /locus_tag="Rv1383"
FT /product="PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN
FT CARA (Carbamoyl-phosphate synthetase glutamine chain)"
FT /function="INVOLVED IN BOTH ARGININE AND PYRIMIDINE
FT BIOSYNTHESIS [CATALYTIC ACTIVITY : 2 ATP + L-GLUTAMINE +
FT CO(2) + H(2)O = 2 ADP + PHOSPHATE + GLUTAMATE + CARBAMOYL
FT PHOSPHATE]"
FT /EC_number="6.3.5.5"
FT /note="Rv1383, (MTCY02B12.17), len: 376 aa. Probable carA,
FT Carbamoyl-phosphate synthase small chain (EC 6.3.5.5),
FT similar to many e.g. CARA_ECOLI|P00907 carbamoyl-phosphate
FT synthase small chain from Escherichia coli (382 aa), FASTA
FT scores: opt: 796, E(): 0, (45.5% identity in 382 aa
FT overlap). Contains PS00442 Glutamine amidotransferases
FT class-I active site. THE GATASE DOMAIN BELONGS TO TYPE-1
FT GLUTAMINE AMIDOTRANSFERASES. SUBUNIT: COMPOSED OF TWO
FT CHAINS; THE SMALL (OR GLUTAMINE) CHAIN PROMOTES THE
FT HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS USED BY THE
FT LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE CARBAMOYL
FT PHOSPHATE."
FT /db_xref="GOA:P71811"
FT /db_xref="InterPro:IPR000991"
FT /db_xref="InterPro:IPR001317"
FT /db_xref="InterPro:IPR002474"
FT /db_xref="InterPro:IPR006220"
FT /db_xref="InterPro:IPR006274"
FT /db_xref="InterPro:IPR011702"
FT /db_xref="InterPro:IPR017926"
FT /db_xref="UniProtKB/Swiss-Prot:P71811"
FT /protein_id="CAB02644.1"
FT /translation="MSKAVLVLEDGRVFTGRPFGATGQALGEAVFSTGMSGYQETLTDP
FT SYHRQIVVATAPQIGNTGWNGEDSESRGERIWVAGYAVRDPSPRASNWRATGTLEDELI
FT RQRIVGIAGIDTRAVVRHLRSRGSMKAGVFSDGALAEPADLIARVRAQQSMLGADLAGE
FT VSTAEPYVVEPDGPPGVSRFTVAALDLGIKTNTPRNFARRGIRCHVLPASTTFEQIAEL
FT NPHGVFLSNGPGDPATADHVVALTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGH
FT RGINIPVVDHATGRVAVTAQNHGFALQGEAGQSFATPFGPAVVSHTCANDGVVEGVKLV
FT DGRAFSVQYHPEAAAGPHDAEYLFDQFVELMAGEGR"
FT misc_feature 173690..173725
FT /note="PS00442 Glutamine amidotransferases class-I active
FT site"
FT CDS 174058..177405
FT /transl_table=11
FT /gene="carB"
FT /locus_tag="Rv1384"
FT /product="PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN
FT CARB (Carbamoyl-phosphate synthetase ammonia chain)"
FT /function="INVOLVED IN BOTH ARGININE AND PYRIMIDINE
FT BIOSYNTHESIS [CATALYTIC ACTIVITY : 2 ATP + L-GLUTAMINE +
FT CO(2) + H(2)O = 2 ADP + PHOSPHATE + GLUTAMATE + CARBAMOYL
FT PHOSPHATE.]"
FT /EC_number="6.3.5.5"
FT /note="Rv1384, (MTCY02B12.18-MTCY21B4.01), len: 1115 aa.
FT Probable carB, Carbamoyl-phosphate synthase large chain (EC
FT 6.3.5.5), similar to many e.g. CARB_ECOLI|P00968 E. coli
FT (1072 aa), FASTA scores: E(): 0, (52.3% identity in 1118 aa
FT overlap). Contains two PS00867 Carbamoyl-phosphate synthase
FT subdomain signature 2 and PS00866
FT Carbamoyl-phosphatesynthase subdomain signature 1. SUBUNIT:
FT COMPOSED OF TWO CHAINS; THE SMALL (OR GLUTAMINE) CHAIN
FT PROMOTES THE HYDROLYSIS OF GLUTAMINE TO AMMONIA, WHICH IS
FT USED BY THE LARGE (OR AMMONIA) CHAIN TO SYNTHESIZE
FT CARBAMOYL PHOSPHATE."
FT /db_xref="GOA:P57689"
FT /db_xref="InterPro:IPR005479"
FT /db_xref="InterPro:IPR005480"
FT /db_xref="InterPro:IPR005481"
FT /db_xref="InterPro:IPR005483"
FT /db_xref="InterPro:IPR006275"
FT /db_xref="InterPro:IPR011607"
FT /db_xref="InterPro:IPR011761"
FT /db_xref="InterPro:IPR013816"
FT /db_xref="InterPro:IPR013817"
FT /db_xref="InterPro:IPR016185"
FT /db_xref="UniProtKB/Swiss-Prot:P57689"
FT /protein_id="CAE55382.1"
FT /translation="MPRRTDLHHVLVIGSGPIVIGQACEFDYSGTQACRVLRAEGLQVS
FT LVNSNPATIMTDPEFADHTYVEPITPAFVERVIAQQAERGNKIDALLATLGGQTALNTA
FT VALYESGVLEKYGVELIGADFDAIQRGEDRQRFKDIVAKAGGESARSRVCFTMAEVRET
FT VAELGLPVVVRPSFTMGGLGSGIAYSTDEVDRMAGAGLAASPSANVLIEESIYGWKEFE
FT LELMRDGHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAILREVG
FT VDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEI
FT VNDITGETPACFEPTLDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFVEAL
FT GKVMRSLETTRAGFWTAPDPDGGIEEALTRLRTPAEGRLYDIELALRLGATVERVAEAS
FT GVDPWFIAQINELVNLRNELVAAPVLNAELLRRAKHSGLSDHQIASLRPELAGEAGVRS
FT LRVRLGIHPVYKTVDTCAAEFEAQTPYHYSSYELDPAAETEVAPQTERPKVLILGSGPN
FT RIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETVSTDYDTADRLYFEPLTFEDVLEV
FT YHAEMESGSGGPGVAGVIVQLGGQTPLGLAHRLADAGVPIVGTPPEAIDLAEDRGAFGD
FT LLSAAGLPAPKYGTATTFAQARRIAEEIGYPVLVRPSYVLGGRGMEIVYDEETLQGYIT
FT RATQLSPEHPVLVDRFLEDAVEIDVDALCDGAEVYIGGIMEHIEEAGIHSGDSACALPP
FT VTLGRSDIAKVRKATEAIAHGIGVVGLLNVQYALKDDVLYVLEANPRASRTVPFVSKAT
FT AVPLAKACARIMLGATIAQLRAEGLLAVTGDGAHAARNAPIAVKEAVLPFHRFRRADGA
FT AIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAQGTVFVSVANRDKRSLVFP
FT VKRLADLGFRVLATEGTAEMLRRNGIPCDDVRKHFEPAQPGRPTMSAVDAIRAGEVNMV
FT INTPYGNSGPRIDGYEIRSAAVAGNIPCITTVQGASAAVQGIEAGIRGDIGVRSLQELH
FT RVIGGVER"
FT misc_feature 174961..174984
FT /note="PS00867 Carbamoyl-phosphate synthase subdomain
FT signature 2"
FT misc_feature 176227..176271
FT /note="PS00866 Carbamoyl-phosphate synthase subdomain
FT signature 1"
FT misc_feature 176614..176637
FT /note="PS00867 Carbamoyl-phosphate synthase subdomain
FT signature 2"
FT CDS 177402..178226
FT /transl_table=11
FT /gene="pyrF"
FT /locus_tag="Rv1385"
FT /product="PROBABLE OROTIDINE 5'-PHOSPHATE DECARBOXYLASE
FT PYRF (OMP decarboxylase) (OMPdecase)"
FT /function="INVOLVED IN THE BIOSYNTHESIS OF PYRIMIDINES
FT [CATALYTIC ACTIVITY : OROTIDINE 5'-PHOSPHATE = UMP +
FT CO(2)]"
FT /EC_number="4.1.1.23"
FT /note="Rv1385, (MTCY21B4.02), len: 274 aa. Probable pyrF,
FT orotidine 5'-phosphate decarboxylase (EC 4.1.1.23),
FT identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274
FT aa). Contains PS00156 Orotidine 5'-phosphate decarboxylase
FT active site. BELONGS TO THE OMP DECARBOXYLASE FAMILY."
FT /db_xref="GOA:P0A5M6"
FT /db_xref="InterPro:IPR001754"
FT /db_xref="InterPro:IPR011060"
FT /db_xref="InterPro:IPR011995"
FT /db_xref="InterPro:IPR013785"
FT /db_xref="InterPro:IPR018089"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5M6"
FT /protein_id="CAB02190.1"
FT /translation="MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFC
FT DICVRAFADFAVVKPQVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMS
FT AYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNA
FT AADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQG
FT GRPEALGGLGGAASSQLLPAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV"
FT misc_feature 177669..177710
FT /note="PS00156 Orotidine 5'-phosphate decarboxylase active
FT site"
FT CDS 178421..178729
FT /transl_table=11
FT /gene="PE15"
FT /locus_tag="Rv1386"
FT /product="PE FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1386, (MTCY21B4.03), len: 102 aa. Member of
FT Mycobacterium tuberculosis PE family (see Brennan & Delogu
FT 2002), similar to many e.g. G913039 ORF 3' OF PGRS TANDEM
FT REPEAT (polymorphic GC-rich sequence) (100 aa), FASTA
FT scores: opt: 149, E(): 0.0013, (31.5% identity in 92 aa
FT overlap); also similar to Q49943|U1756A (99 aa) (34.7%
FT identity in 95 aa overlap) and G466937|U1620K (100 aa)
FT (36.2% identity in 69 aa overlap)."
FT /db_xref="InterPro:IPR000084"
FT /db_xref="UniProtKB/Swiss-Prot:P0A682"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55383.1"
FT /translation="MTLRVVPESLAGASAAIEAVTARLAAAHAAAAPFIAAVIPPGSDS
FT VSVCNAVEFSVHGSQHVAMAAQGVEELGRSGVGVAESGASYAARDALAAASYLSGGL"
FT CDS 178726..180345
FT /transl_table=11
FT /gene="PPE20"
FT /locus_tag="Rv1387"
FT /product="PPE FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1387, (MTCY21B4.04), len: 539 aa. Member of
FT Mycobacterium tuberculosis PPE family of proteins, similar
FT to many e.g. Y05F_MYCTU|Q10892 hypothetical 46.9 kd protein
FT cy251.15 (463 aa), FASTA scores: E(): 4.2e-26, (37.7%
FT identity in 531 aa overlap); similar also to MTCY274.23c
FT (37.5% identity in 168 aa overlap). Contains PS00343
FT Gram-positive cocci surface proteins 'anchoring'
FT hexapeptide."
FT /db_xref="InterPro:IPR000030"
FT /db_xref="UniProtKB/Swiss-Prot:Q7D8H6"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55384.1"
FT /translation="MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQYAEAAS
FT EVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMAAQQHVVIEAYTAAVE
FT LMPTQVELAANQIKLAVLVATNFFGINTIPIAINEAEYVEMWVRAATTMATYSTVSRSA
FT LSAMPHTSPPPLILKSDELLPDTGEDSDEDGHNHGGHSHGGHARMIDNFFAEILRGVSA
FT GRIVWDPVNGTLNGLDYDDYVYPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFLL
FT YVVVVDLPTHIAQIATWLGQYPQLLSAALTGVIAHLGAITGLAGLSGLSAIPSAAIPAV
FT VPELTPVAAAPPMLAVAGVGPAVAAPGMLPASAPAPAAAAGATAAGPTPPATGFGGFPP
FT YLVGGGGPGIGFGSGQSAHAKAAASDSAAAESAAQASARAQARAARRGRSAAKARGHRD
FT EFVTMDMGFDAAAPAPEHQPGARASDCGAGPIGFAGTVRKEAVVKAAGLTTLAGDDFGG
FT GPTMPMMPGTWTHDQGVFDEHR"
FT misc_feature 179272..179289
FT /note="PS00343 Gram-positive cocci surface proteins
FT 'anchoring' hexapeptide"
FT CDS 180651..181223
FT /transl_table=11
FT /gene="mihF"
FT /locus_tag="Rv1388"
FT /product="PUTATIVE INTEGRATION HOST FACTOR MIHF"
FT /function="UNKNOWN"
FT /note="Rv1388, (MTCY21B4.05), len: 190 aa. Putative mihF,
FT integration host factor. Almost identical to, but longer
FT than, P96802|U75344 Mycobacterium smegmatis integration
FT host factor (mIHF) for mycobacteriophage L5 (105 aa), FASTA
FT scores: E(): 0, (96.1% identity in 102 aa overlap)."
FT /db_xref="UniProtKB/TrEMBL:P71658"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02193.1"
FT /translation="MLGNTIHVPCQPCRHGHGAPSRGLRGRPADRWPVARATPTLHVCP
FT QNQGVGLDFVRKPEYGRLRWPAYPAGTNNDRLISMRDGGIVALPQLTDEQRAAALEKAA
FT AARRARAELKDRLKRGGTNLTQVLKDAESDEVLGKMKVSALLEALPKVGKVKAQEIMTE
FT LEIAPTRRLRGLGDRQRKALLEKFGSA"
FT CDS 181358..181984
FT /transl_table=11
FT /gene="gmk"
FT /locus_tag="Rv1389"
FT /product="PROBABLE GUANYLATE KINASE GMK"
FT /function="ESSENTIAL FOR RECYCLING GMP AND INDIRECTLY, CGMP
FT [CATALYTIC ACTIVITY : ATP + GMP = ADP + GDP]"
FT /EC_number="2.7.4.8"
FT /note="Rv1389, (MTCY21B4.06), len: 208 aa. Probable gmk,
FT guanylate kinase (EC 2.7.4.8), similar to e.g.
FT KGUA_ECOLI|P24234 guanylate kinase from Escherichia coli
FT (207 aa), FASTA scores: opt: 424, E(): 6.6e-20, (35.9%
FT identity in 184 aa overlap). Contains PS00017
FT ATP/GTP-binding site motif A (P-loop), PS00856 Guanylate
FT kinase signature. BELONGS TO THE GUANYLATE KINASE FAMILY."
FT /db_xref="GOA:P0A5I4"
FT /db_xref="InterPro:IPR008144"
FT /db_xref="InterPro:IPR008145"
FT /db_xref="InterPro:IPR017665"
FT /db_xref="InterPro:IPR020590"
FT /db_xref="PDB:1S4Q"
FT /db_xref="PDB:1Z8F"
FT /db_xref="PDB:1ZNW"
FT /db_xref="PDB:1ZNX"
FT /db_xref="PDB:1ZNY"
FT /db_xref="PDB:1ZNZ"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5I4"
FT /protein_id="CAB02172.1"
FT /translation="MSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERI
FT PNLHFSVSATTRAPRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQ
FT PVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETADVI
FT QRRLDTARIELAAQGDFDKVVVNRRLESACAELVSLLVGTAPGSP"
FT misc_feature 181439..181462
FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT misc_feature 181520..181573
FT /note="PS00856 Guanylate kinase signature"
FT CDS 182050..182382
FT /transl_table=11
FT /gene="rpoZ"
FT /locus_tag="Rv1390"
FT /product="PROBABLE DNA-DIRECTED RNA POLYMERASE (OMEGA
FT CHAIN) RPOZ (TRANSCRIPTASE OMEGA CHAIN) (RNA POLYMERASE
FT OMEGA SUBUNIT)"
FT /function="PROMOTES RNA POLYMERASE ASSEMBLY. LATCHES THE
FT N-AND C-TERMINAL REGIONS OF THE BETA' SUBUNIT THEREBY
FT FACILTATING ITS INTERACTION WITH THE BETA AND ALPHA
FT SUBUNITS (BY SIMILARITY) [CATALYTIC ACTIVITY: N nucleoside
FT triphosphate = N diphosphate + {RNA}N]."
FT /EC_number="2.7.7.6"
FT /note="Rv1390, (MTCY21B4.07), len: 110 aa. Probable rpoZ,
FT DNA-directed RNA polymerase omega chain (EC 2.7.7.6).
FT BELONGS TO THE RNA POLYMERASE OMEGA CHAIN FAMILY."
FT /db_xref="GOA:P66721"
FT /db_xref="InterPro:IPR003716"
FT /db_xref="InterPro:IPR006110"
FT /db_xref="UniProtKB/Swiss-Prot:P66721"
FT /protein_id="CAB02173.1"
FT /translation="MSISQSDASLAAVPAVDQFDPSSGASGGYDTPLGITNPPIDELLD
FT RVSSKYALVIYAAKRARQINDYYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHADLL
FT EHTEGE"
FT CDS 182398..183654
FT /transl_table=11
FT /gene="dfp"
FT /locus_tag="Rv1391"
FT /product="PROBABLE DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN
FT HOMOLOG DFP"
FT /function="FLAVOPROTEIN AFFECTING SYNTHESIS OF DNA AND
FT PANTOTHENATE METABOLISM"
FT /note="Rv1391, (MTCY21B4.08), len: 418 aa. Probable dfp,
FT DNA/pantothenate metabolism flavoprotein homolog , similar
FT to many e.g. DFP_ECOLI|P24285 Escherichia coli (430 aa),
FT FASTA scores: opt: 763, E(): 0, (40.2% identity in 408 aa
FT overlap)."
FT /db_xref="GOA:P67733"
FT /db_xref="InterPro:IPR003382"
FT /db_xref="InterPro:IPR005252"
FT /db_xref="InterPro:IPR007085"
FT /db_xref="UniProtKB/Swiss-Prot:P67733"
FT /protein_id="CAB02174.1"
FT /translation="MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTES
FT ALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRA
FT DDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSG
FT AGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQG
FT YAVARVAAQRGADVTLIAGHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAA
FT AVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAET
FT GDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKT
FT LMASRIVDAIVTFLAGCSS"
FT CDS 183782..184993
FT /transl_table=11
FT /gene="metK"
FT /locus_tag="Rv1392"
FT /product="PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE METK
FT (MAT) (AdoMet synthetase) (Methionine adenosyltransferase)"
FT /function="Involved in the activated Methyl cycle.
FT Catalyzes the formation of S-adenosylmethionine from
FT methionine and ATP. The overall synthetic reaction is
FT composed of two sequential steps, AdoMet formation and the
FT subsequent tripolyphosphate hydrolysis which occurs prior
FT to release of AdoMet from the enzyme. [CATALYTIC ACTIVITY :
FT ATP + L-METHIONINE + H(2)O = PHOSPHATE + DIPHOSPHATE +
FT S-ADENOSYL-L-METHIONINE]"
FT /EC_number="2.5.1.6"
FT /note="Rv1392, (MTCY21B4.09), len: 403 aa. Probable metK,
FT S-adenosylmethionine synthetase (EC 2.5.1.6), similar to
FT many e.g. METK_STAAU|P50307 Staphylococcus aureus (397 aa),
FT FASTA scores: opt: 1484, E(): 0, (58.0% identity in 400 aa
FT overlap). Contains PS00376 S-adenosylmethionine synthetase
FT signature 1, PS00377 S-adenosylmethionine synthetase
FT signature 2. BELONGS TO THE ADOMET SYNTHETASE FAMILY."
FT /db_xref="GOA:P77899"
FT /db_xref="InterPro:IPR002133"
FT /db_xref="UniProtKB/Swiss-Prot:P77899"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02194.1"
FT /translation="MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVE
FT TLVTTGQVHVVGEVTTSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIGIGAQ
FT SPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELMPLPIALAHRLSRR
FT LTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVVISTQHAADIDLEKTLDPDIREK
FT VLNTVLDDLAHETLDASTVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGG
FT AFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTET
FT EDPVKIEKAIGEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDL
FT KRAI"
FT misc_feature 184172..184189
FT /note="PS00376 S-adenosylmethionine synthetase signature 1"
FT misc_feature 184616..184642
FT /note="PS00377 S-adenosylmethionine synthetase signature 2"
FT CDS complement(185066..186544)
FT /transl_table=11
FT /locus_tag="Rv1393c"
FT /product="PROBABLE MONOXYGENASE"
FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT METABOLISM"
FT /EC_number="1.14.13.-"
FT /note="Rv1393c, (MTCY21B4.10c), len: 492 aa. Probable
FT monooxygenase (EC 1.14.13.-), similar to others e.g.
FT CYMO_ACISP|P12015 cyclohexanone monooxygenase (EC
FT 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA scores:
FT E(): 0, (33.0% identity in 473 aa overlap); also to
FT Rv3083|MTCY31.20|E241788 hypothetical 55.0 kDa protein from
FT Mycobacterium tuberculosis (495 aa) (36.3% identity in 490
FT aa overlap); and Rv0565c, Rv3854c, Rv3049c, Rv0892."
FT /db_xref="GOA:P71662"
FT /db_xref="InterPro:IPR002937"
FT /db_xref="InterPro:IPR013027"
FT /db_xref="UniProtKB/TrEMBL:P71662"
FT /protein_id="CAB02175.1"
FT /translation="MMPDYHALIVGAGFSGIGAAIKLDRAGFSDYLVVEAGDGVGGTWH
FT WNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYGIRSRIRLNTKV
FT LAAEFDDEHSLWRVQTDPGGEITARFLISACGILTVPKLPDIDGVDSFEGVTMHTARWD
FT HTQDLTGKRVGIIGTGASAVQVIPEMAPIVSHLTVFQRTPIWCFPKFDVPLPTAVRWAM
FT RIPGGKAVHRLLSQAFVEATFPIAAHYFAVFPLAKHMESAGRRYLRQQVHDPVVREQLT
FT PRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTDGASHEIDVLVLATGF
FT KVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPGYPNFFTVFGPYGYVGSSYF
FT ALIETQAHHIIRCLKRARRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSY
FT YFDKNGDVPLRPTTTVEAYWRSRRFDLGDYRISS"
FT CDS complement(186541..187926)
FT /transl_table=11
FT /gene="cyp132"
FT /locus_tag="Rv1394c"
FT /product="PROBABLE CYTOCHROME P450 132 CYP132"
FT /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE
FT MONOOXYGENASES. IT OXIDIZES A VARIETY OF STRUCTURALLY
FT UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND
FT XENOBIOTICS."
FT /EC_number="1.14.-.-"
FT /note="Rv1394c, (MT1439, MTCY21B4.11c), len: 461 aa.
FT Probable cyp132, cytochrome P450 132 (EC 1.14.-.-). Some
FT similarity to others e.g. CP4B_HUMAN|P13584 human
FT cytochrome p450 (511 aa), FASTA scores: opt: 486, E():
FT 7.4e-21, (28.6% identity in 423 aa overlap); etc. Contains
FT PS00086 Cytochrome P450 cysteine heme-iron ligand
FT signature. MAY BELONG TO THE CYTOCHROME P450 FAMILY."
FT /db_xref="GOA:P77900"
FT /db_xref="InterPro:IPR001128"
FT /db_xref="InterPro:IPR002401"
FT /db_xref="InterPro:IPR017972"
FT /db_xref="InterPro:IPR017973"
FT /db_xref="UniProtKB/Swiss-Prot:P77900"
FT /protein_id="CAE55385.1"
FT /translation="MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGSD
FT ITRFRCAGRRFVSISHPDYVDHVLHEARLKYVKSDEYGPIRATAGLNLLTDEGDSWARH
FT RGALNSTFARRHLRGLVGLMIDPIADVTAARVPGAQFDMHQSMVETTLRVVANALFSQD
FT FGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLREMQEI
FT TLTLDRAINSVIDRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGHETTAN
FT AMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSVWI
FT IAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPTDRPRCAY
FT LPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRPKHGVHVIG
FT RRR"
FT misc_feature complement(186694..186723)
FT /note="PS00086 Cytochrome P450 cysteine heme-iron ligand
FT signature"
FT CDS 188004..189038
FT /transl_table=11
FT /locus_tag="Rv1395"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1395, (MTCY21B4.12), len: 344 aa. Probable
FT transcriptional regulatory protein (see citation below),
FT similar to many e.g. URER_PROMI|Q02458 urease operon
FT transcriptional activator from Proteus mirabilis (293 aa),
FT FASTA scores: E():1.5e-08, (41.7% identity in 84 aa
FT overlap); YHIX_ECOLI|P37639 hypothetical transcriptional
FT regulatory protein from Escherichia coli (274 aa), FASTA
FT scores: opt: 238, E(): 3.5e-09, (27.3% identity in 249 aa
FT overlap); and G296916|X68281 POSSIBLE VIRULENCE-REGULATING
FT protein from Mycobacterium tuberculosis (339 aa), FASTA
FT scores: opt: 228, E(): 1.9e-08, (27.0% identity in 278 aa
FT overlap). Helix turn helix motif present, aa 261-282 (+4.68
FT SD). BELONGS TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL
FT REGULATORS. 3' part corrected since first submission (-14
FT aa)."
FT /db_xref="GOA:P68913"
FT /db_xref="InterPro:IPR000005"
FT /db_xref="InterPro:IPR009057"
FT /db_xref="InterPro:IPR012287"
FT /db_xref="InterPro:IPR018060"
FT /db_xref="InterPro:IPR020449"
FT /db_xref="UniProtKB/Swiss-Prot:P68913"
FT /protein_id="CAE55386.1"
FT /translation="MGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPADL
FT DDPDAVVGALDEITAVRRLLARLPDDAGIGIDVGSRFALTHFGLFGFAVMSCGTLRELL
FT TIAMRYFALTTMHVDITLFETADDCLVELDASHLPADVRGFFIERDIAGIIATTTSFAL
FT PLAAKYADQVSAELAVDAELLRPLLELVPVHDVAFGRAHNRVHFPRAMFDEPLPQADRH
FT TLEMCIAQCDVLMQRNERRRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRLA
FT EEGTSFRALLGEARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYGVAPSEY
FT SRRG"
FT CDS complement(189084..190814)
FT /transl_table=11
FT /gene="PE_PGRS25"
FT /locus_tag="Rv1396c"
FT /product="PE-PGRS FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1396c, (MTCY21B4.13c), len: 576 aa. Member of the
FT Mycobacterium tuberculosis PE family, PGRS subfamily of
FT gly-rich proteins (see Brennan & Delogu 2002), strong
FT similarity to many e.g. glycine rich protein
FT MTCY130.10C|E245019 (603 aa), FASTA scores: opt: 1945, E():
FT 0, (57.5% identity in 619 aa overlap). Contains PS00017
FT ATP/GTP-binding site motif A, similar to other PGRS-type
FT sequences."
FT /db_xref="InterPro:IPR000084"
FT /db_xref="UniProtKB/TrEMBL:P71664"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55387.1"
FT /translation="MSFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAAGAD
FT EVSAAVAALFSGHAQTYQALRTQAAAFHQQIVQTLTSTAGAYASAEAANVEQQLLGAIN
FT APTMALLGRPLIGHGADGAPGTGQAGGAGGILYGNGGNGGSGATGQAGGAGGAAGLIGH
FT GGAGGLGGTGASGGAGGAGGWLWGNGGAGGNGGVGVAGDPGGVGGAGGAGGAAGLWGSG
FT GSGGTGGQGGVGGGKSGDGGTGGIGGAGGGGGWLHGDGGAGGHGGQGGTGVSSGGNGGA
FT GGTGGDGRGLSGSGGAGGRGGQTGVGGKVGENNFGGAGGAGGTGGLIGNGGAGGNGGQG
FT AISGAGGAGGNAWLIGDGGAGGNGGDIRGQGGGAGGAGGAGGQLIGNGGTGGAGGTVTS
FT PNGLGGAGGAGGSAGLIGHGGTGGAGGHSAQGPDGNGGIGGAGGAGGNGGQLYGTGGTG
FT GTGGKGGDGFGVFGKGGAGGTGGRGGAAGLIGDAGTGGTGGKGGTAGEDGTGGNGGTGG
FT NGGAAVLIGNGGGGGAGGNGGAGNDGTPGNGGGGGVGGTGGTLFGQPGQPGPPGQPGPA
FT "
FT misc_feature complement(190101..190124)
FT /note="PS00017 ATP/GTP-binding site motif A"
FT CDS complement(191069..191470)
FT /transl_table=11
FT /locus_tag="Rv1397c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1397c, (MTCY21B4.14c), len: 133 aa. Conserved
FT hypothetical protein, similar to Mycobacterium tuberculosis
FT protein MTCY159.08C|Rv2548 (125 aa), FASTA scores: E():
FT 2.3e-14, (42.4% identity in 125 aa overlap)."
FT /db_xref="InterPro:IPR002716"
FT /db_xref="UniProtKB/TrEMBL:P71665"
FT /protein_id="CAB02178.1"
FT /translation="MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGG
FT MRTAERREVWRLLASFRVQPATEVIARRAGDMMRRYRRSHNRIGLGDYLIAATADVQDL
FT QLATLNVWHFPMFEQLKPPFAVPGHRPRA"
FT CDS complement(191467..191724)
FT /transl_table=11
FT /locus_tag="Rv1398c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1398c, (MTCY21B4.15c), len: 85 aa. Conserved
FT hypothetical protein, similar to Mycobacterium tuberculosis
FT proteins Rv2547|MTCY159.09C (85 aa), FASTA scores: E():
FT 0.0035, (37.1% identity in 62 aa overlap); Rv0581, Rv2871,
FT Rv1241, etc."
FT /db_xref="GOA:P64835"
FT /db_xref="InterPro:IPR002145"
FT /db_xref="UniProtKB/Swiss-Prot:P64835"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02179.1"
FT /translation="MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDD
FT LASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQVWRATS"
FT CDS complement(191807..192766)
FT /transl_table=11
FT /gene="lipH"
FT /locus_tag="Rv1399c"
FT /product="PROBABLE LIPASE LIPH"
FT /function="UNKNOWN, BUT SUPPOSED INVOLVED IN LIPID
FT METABOLISM"
FT /EC_number="3.1.-.-"
FT /note="Rv1399c, (MTCY21B4.16c), len: 319 aa. Possible LipH,
FT lipase (EC 3.1.-.-), most similar to G695278 lipase like
FT enzyme from Ralstonia eutropha (364 aa), FASTA scores: opt:
FT 648, E(): 4.4e-34, (37.3% identity in 327 aa ov erlap),
FT similar to Mycobacterium tuberculosis hypothetical lipases
FT e.g. Rv2284, Rv2485c, Rv1426c, etc."
FT /db_xref="GOA:P71667"
FT /db_xref="HSSP:1JJI"
FT /db_xref="InterPro:IPR013094"
FT /db_xref="UniProtKB/TrEMBL:P71667"
FT /protein_id="CAB02180.1"
FT /translation="MTEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTP
FT PELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDNLPVVVYYHGGGWSLGGLDTHDPVA
FT RAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAGDSA
FT GGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAW
FT YVPGLDISDHTMLPTTLAPGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVE
FT LSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA"
FT CDS complement(192791..193753)
FT /transl_table=11
FT /gene="lipI"
FT /locus_tag="Rv1400c"
FT /product="PROBABLE LIPASE LIPH"
FT /function="UNKNOWN, BUT POSSIBLY INVOLVED IN LIPID
FT METABOLISM"
FT /EC_number="3.1.-.-"
FT /note="Rv1400c, (MTCY21B4.17c), len: 320 aa. Possible lipI,
FT lipase (EC 3.1.-.-), most similar to G695278 lipase like
FT enzyme (364 aa), FASTA sscores: opt: 611, E(): 3.5e-30,
FT (36.6% identity in 352 aa overlap); similar to M.
FT tuberculosis hypothetical lipases e.g. Rv1399c|MTCY21B4.16c
FT (58.1% identical in 315 aa overlap); Rv1426c, Rv2284, etc."
FT /db_xref="GOA:P71668"
FT /db_xref="HSSP:1JJI"
FT /db_xref="InterPro:IPR002168"
FT /db_xref="InterPro:IPR013094"
FT /db_xref="UniProtKB/TrEMBL:P71668"
FT /protein_id="CAB02181.1"
FT /translation="MPSLDNTADEKPAIDPILLKVLDAVPFRLSIDDGIEAVRQRLRDL
FT PRQPVHPELRVVDLAIDGPAGPIGTRIYWPPTCPDQAEAPVVLYFHGGGFVMGDLDTHD
FT GTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAATRWVAEHGRQVGADLGRIAVAG
FT DSAGGTIAAVIAQRARDMGGPPIVFQLLWYPSTLWDQSLPSLAENADAPILDVKAIAAF
FT SRWYAGEIDLHNPPAPMAPGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAAAGVPV
FT EVHNAQTLVHGYVGYAGVVPAATEATNRGLVALRVVLHG"
FT CDS 193887..194489
FT /transl_table=11
FT /locus_tag="Rv1401"
FT /product="POSSIBLE MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1401, (MTCY21B4.18), len: 200 aa. Possible
FT membrane protein."
FT /db_xref="GOA:P64837"
FT /db_xref="InterPro:IPR012506"
FT /db_xref="UniProtKB/Swiss-Prot:P64837"
FT /protein_id="CAB02195.1"
FT /translation="MLQPAFKASMAVLLAAAAVAHPIGRERRWLVPALLLSATGDWLLA
FT IPWWTWAFVFGLGAFLLAHLCFIGALLPLARQAAPSRGRVAAVVAMCVASAGLLVWFWP
FT HLGKDNLTIPVTVYIVALSAMVCTALLARLPTIWTAVGAVCFAASDSMIGIGRFILGNE
FT ALAVPIWWSYAAAEILITAGFFFGREVPDNAAAPTDS"
FT CDS 194570..196537
FT /transl_table=11
FT /gene="priA"
FT /locus_tag="Rv1402"
FT /product="PUTATIVE PRIMOSOMAL PROTEIN N' PRIA (Replication
FT factor Y)"
FT /function="RECOGNIZES A SPECIFIC HAIRPIN SEQUENCE ON PHIX
FT SSDNA; THIS STRUCTURE IS THEN RECOGNIZED AND BOUND BY
FT PROTEINS PRIB AND PRIC. FORMATION OF THE PRIMOSOME PROCEEDS
FT WITH THE SUBSEQUENT ACTIONS OF DNAB, DNAC, DNAT AND
FT PRIMASE. PRIA THEN FUNCTIONS AS A HELICASE WITHIN THE
FT PRIMOSOME"
FT /note="Rv1402, (MTCY21B4.19), len: 655 aa. Putative priA,
FT primosomal protein N'. Similar to e.g. PRIA_ECOLI|P17888
FT primosomal protein N' (replication factor Y) (732 aa),
FT FASTA scores, opt: 386, E(): 1.3e-16, (27.6% identity in
FT 711 aa overlap). Compared to other bacterial priA, it has a
FT very divergent helicase domain. BELONGS TO THE HELICASE
FT FAMILY. PRIA SUBFAMILY."
FT /db_xref="GOA:P0A5A5"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5A5"
FT /protein_id="CAB02196.1"
FT /translation="MLSVPHLDRDFDYLVPAEHSDDAQPGVRVRVRFHGRLVDGFVLER
FT RSDSDHHGKLGWLDRVVSPEPVLTTEIRRLVDAVAARYAGTRQDVLRLAVPARHARVER
FT EITTAPGRPVVAPVDPSGWAAYGRGRQFLAALADSRAARAVWQALPGELWADRFAEAAA
FT QTVRAGRTVLAIVPDQRDLDTLWQAATALVDEHSVVALSAGLGPEARYRRWLAALRGSA
FT RLVIGTRSAVFAPLSELGLVMVWADADDSLAEPRAPYPHAREVAMLRAHQARCAALIGG
FT YARTAEAHALVRSGWAHDVVAPRPEVRARSPRVVALDDSGYDDARDPAARTARLPSIAL
FT RAARSALQSGAPVLVQVPRRGYIPSLACGRCRAIARCRSCTGPLSLQGAGSPGAVCRWC
FT GRVDPTLRCVRCGSDVVRAVVVGARRTAEELGRAFPGTAVITSAGDTLVPQLDAGPALV
FT VATPGAEPRAPGGYGAALLLDSWALLGRQDLRAAEDALWRWMTAAALVRPRGAGGVVTV
FT VAESSIPTVQSLIRWDPVGHAEAELAARTEVGLPPSVHIAALDGPAGTVTALLEAARLP
FT DPDRLQADLLGPVDLPPGVRRPAGIPADAPVIRMLLRVCREQGLELAASLRRGIGVLSA
FT RQTRQTRSLVRVQIDPLHIG"
FT CDS complement(196555..197379)
FT /transl_table=11
FT /locus_tag="Rv1403c"
FT /product="PUTATIVE METHYLTRANSFERASE"
FT /function="CAUSES METHYLATION"
FT /EC_number="2.1.1.-"
FT /note="Rv1403c, (MTCY21B4.20c), len: 274 aa. Putative
FT methyltransferase (EC 2.1.1.-), similar to
FT PMTA_RHOSH|Q05197 phosphatidylethanolamine
FT m-methyltransferase (203 aa), FASTA scores: opt: 217, E():
FT 1.1e-07, (37.1% identity in 105 aa overlap); similar to
FT Rv1405c|MTCY21B4.22c (59.3% identity in 273 aa overlap) and
FT to Rv1523, Rv2952, etc."
FT /db_xref="GOA:P64839"
FT /db_xref="InterPro:IPR013216"
FT /db_xref="UniProtKB/Swiss-Prot:P64839"
FT /protein_id="CAB02182.1"
FT /translation="MTVYTPTSERQAPATTHRQMWALGDYAAIAEELLAPLGPILVSTS
FT GIRRGDRVLDVAAGSGNVSIPAAMAGAHVTASDLTPELLRRAQARAAAAGLELGWREAN
FT AEALPFSAGEFDAVLSTIGVMFAPRHQRTADELARVCRRGGKISTLNWTPEGFYGKLLS
FT TIRPYRPTLPAGAPHEVWWGSEDYVSGLFRDHVSDIRTRRGSLTVDRFGCPDECRDYFK
FT NFYGPAINAYRSIADSPECVATLDAEITELCREYLCDGVMQWEYLIFTARKC"
FT CDS 197548..198030
FT /transl_table=11
FT /locus_tag="Rv1404"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1404, (MTCY21B4.21), len: 160 aa. Probable
FT transcriptional regulatory protein, some similarity to
FT MARR_ECOLI|P27245 multiple antibiotic resistance protein
FT from Escherichia coli (125 aa), FASTA scores: opt: 136,
FT E(): 0.004, (35.1% identity in 74 aa overlap)."
FT /db_xref="GOA:P71672"
FT /db_xref="InterPro:IPR000835"
FT /db_xref="InterPro:IPR011991"
FT /db_xref="PDB:2NYX"
FT /db_xref="UniProtKB/TrEMBL:P71672"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02183.1"
FT /translation="MMPTEYPATAEESVDVITDALLTASRLLVAISAHSIAQVDENITI
FT PQFRTLVILSNHGPINLATLATLLGVQPSATGRMVDRLVGAELIDRLPHPTSRRELLAA
FT LTKRGRDVVRQVTEHRRTEIARIVEQMAPAERHGLVRALTAFTEAGGEPDARYEIE"
FT CDS complement(198102..198926)
FT /transl_table=11
FT /locus_tag="Rv1405c"
FT /product="PUTATIVE METHYLTRANSFERASE"
FT /function="CAUSES METHYLATION"
FT /EC_number="2.1.1.-"
FT /note="Rv1405c, (MTCY21B4.22c), len: 274 aa. Putative
FT methyltransferase (EC 2.1.1.-), most similar to
FT PMTA_RHOSH|Q05197 phosphatidylethanolamine
FT m-methyltransferase (203 aa), FASTA scores: opt: 219, E():
FT 2.6e-07, (29.9% identity in 144 aa overlap); similar to
FT Rv1403c|MTCY21B4.20c (59.3% identity in 273 aa overlap),
FT Rv1523, Rv2952, etc."
FT /db_xref="GOA:P64841"
FT /db_xref="InterPro:IPR013216"
FT /db_xref="UniProtKB/Swiss-Prot:P64841"
FT /protein_id="CAB02184.1"
FT /translation="MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGPILVAAA
FT GIGPGVRVLDVAAGSGNISLPAAKTGATVISTDLTPELLQRSQARAAQQGLTLQYQEAN
FT AQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRPGGTIGVISWTCEGFFGRMLA
FT TIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFDTAQAVHDYFK
FT NNYGPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSDGVMEWEYLLLTAEKR"
FT CDS 199123..200061
FT /transl_table=11
FT /gene="fmt"
FT /locus_tag="Rv1406"
FT /product="PROBABLE METHIONYL-TRNA FORMYLTRANSFERASE FMT"
FT /function="MODIFY THE FREE AMINO GROUP OF THE AMINOACYL
FT MOIETY OF METHIONYL-TRNA(FMET). THE FORMYL GROUP APPEARS TO
FT PLAY A DUAL ROLE IN THE INITIATOR IDENTITY OF
FT N-FORMYLMETHIONYL-TRNA BY:(I) PROMOTING ITS RECOGNITION BY
FT IF2 AND (II) IMPAIRING ITS BINDING TO EFTU-GTP. [CATALYTIC
FT ACTIVITY : 10-FORMYLTETRAHYDROFOLATE + L-METHIONYL-TRNA +
FT H(2)O = TETRAHYDROFOLATE + N-FORMYLMETHIONYL-TRNA]"
FT /EC_number="2.1.2.9"
FT /note="Rv1406, (MTCY21B4.23), len: 312 aa. Probable fmt,
FT methionyl-tRNA formyltransferase (EC 2.1.2.9), similar to
FT many e.g. FMT_ECOLI|P23882 Escherichia coli (314 aa), FASTA
FT scores: opt: 616, E(): 6.7e-31, (39.3% identity in 303 aa
FT overlap). BELONGS TO THE FMT FAMILY."
FT /db_xref="GOA:P64134"
FT /db_xref="InterPro:IPR002376"
FT /db_xref="InterPro:IPR005793"
FT /db_xref="InterPro:IPR005794"
FT /db_xref="InterPro:IPR011034"
FT /db_xref="InterPro:IPR015518"
FT /db_xref="UniProtKB/Swiss-Prot:P64134"
FT /protein_id="CAB02185.1"
FT /translation="MRLVFAGTPEPALASLRRLIESPSHDVIAVLTRPDAASGRRGKPQ
FT PSPVAREAAERGIPVLRPSRPNSAEFVAELSDLAPECCAVVAYGALLGGPLLAVPPHGW
FT VNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPIYGVVTEVIQPTDTAG
FT DLLKRLAVSGAALLSTTLDGIADQRLTPRPQPADGVSVAPKITVANARVRWDLPAAVVE
FT RRIRAVTPNPGAWTLIGDLRVKLGPVHLDAAHRPSKPLPPGGIHVERTSVWIGTGSEPV
FT RLGQIQPPGKKLMNAADWARGARLDLAARAT"
FT CDS 200058..201431
FT /transl_table=11
FT /gene="fmu"
FT /locus_tag="Rv1407"
FT /product="PROBABLE FMU PROTEIN (SUN PROTEIN)"
FT /function="UNKNOWN"
FT /note="Rv1407, (MTCY21B4.24), len: 457 aa. Probable fmu
FT protein, similar to SUN_ECOLI|P36929 sun protein (fmu
FT protein) from Escherichia coli (429 aa), FASTA scores: E():
FT 2.5e-20, (30.6% identity in 451 aa overlap)."
FT /db_xref="GOA:P71675"
FT /db_xref="InterPro:IPR001678"
FT /db_xref="InterPro:IPR006027"
FT /db_xref="InterPro:IPR018314"
FT /db_xref="UniProtKB/Swiss-Prot:P71675"
FT /protein_id="CAB02186.1"
FT /translation="MTPRSRGPRRRPLDPARRAAFETLRAVSARDAYANLVLPALLAQR
FT GIGGRDAAFATELTYGTCRARGLLDAVIGAAAERSPQAIDPVLLDLLRLGTYQLLRTRV
FT DAHAAVSTTVEQAGIEFDSARAGFVNGVLRTIAGRDERSWVGELAPDAQNDPIGHAAFV
FT HAHPRWIAQAFADALGAAVGELEAVLASDDERPAVHLAARPGVLTAGELARAVRGTVGR
FT YSPFAVYLPRGDPGRLAPVRDGQALVQDEGSQLVARALTLAPVDGDTGRWLDLCAGPGG
FT KTALLAGLGLQCAARVTAVEPSPHRADLVAQNTRGLPVELLRVDGRHTDLDPGFDRVLV
FT DAPCTGLGALRRRPEARWRRQPADVAALAKLQRELLSAAIALTRPGGVVLYATCSPHLA
FT ETVGAVADALRRHPVHALDTRPLFEPVIAGLGEGPHVQLWPHRHGTDAMFAAALRRLT"
FT CDS 201456..202154
FT /transl_table=11
FT /gene="rpe"
FT /locus_tag="Rv1408"
FT /product="PROBABLE RIBULOSE-PHOSPHATE 3-EPIMERASE RPE (PPE)
FT (R5P3E) (Pentose-5-phosphate 3-epimerase)"
FT /function="INVOLVED IN THE CALVIN CYCLE [CATALYTIC ACTIVITY
FT : D-RIBULOSE 5-PHOSPHATE = D-XYLULOSE 5- PHOSPHATE]"
FT /EC_number="5.1.3.1"
FT /note="Rv1408, (MTCY21B4.25), len: 232 aa. Probable rpe,
FT ribulose-phosphate 3-epimerase (EC 5.1.3.1), similar to
FT many e.g. CXEC_ALCEU|P40117 (241 aa), FASTA scores: opt:
FT 638, E(): 1.5e-34, (48.3% identity in 234 aa overlap); and
FT RPE_ECOLI|P32661 ribulose-phosphate 3-epimerase (225 aa),
FT FASTA scores: E(): 0, (46.2% identity in 221 aa overlap).
FT Contains PS01085 Ribulose-phosphate 3-epimerase family
FT signature 1. BELONGS TO THE RIBULOSE-PHOSPHATE 3-EPIMERASE
FT FAMILY."
FT /db_xref="GOA:P65760"
FT /db_xref="InterPro:IPR000056"
FT /db_xref="InterPro:IPR011060"
FT /db_xref="InterPro:IPR013785"
FT /db_xref="UniProtKB/Swiss-Prot:P65760"
FT /protein_id="CAB02187.1"
FT /translation="MSLMAGSTGGPLIAPSILAADFARLADEAAAVNGADWLHVDVMDG
FT HFVPNLTIGLPVVESLLAVTDIPMDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPV
FT GVARDIRAAGAKAGISVKPGTPLEPYLDILPHFDTLLVMSVEPGFGGQRFIPEVLSKVR
FT AVRKMVDAGELTILVEIDGGINDDTIEQAAEAGVDCFVAGSAVYGADDPAAAVAALRRQ
FT AGAASLHLSL"
FT misc_feature 201567..201611
FT /note="PS01085 Ribulose-phosphate 3-epimerase family
FT signature 1"
FT misc_feature 201867..201941
FT /note="PS01086 Ribulose-phosphate 3-epimerase family
FT signature 2"
FT CDS 202151..203170
FT /transl_table=11
FT /gene="ribG"
FT /locus_tag="Rv1409"
FT /standard_name="ribD"
FT /product="PROBABLE BIFUNCTIONAL riboflavin biosynthesis
FT protein RIBG : Diaminohydroxyphosphoribosylaminopyrimidine
FT deaminase (Riboflavin-specific deaminase) +
FT 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP
FT reductase)"
FT /function="INVOLVED IN RIBOFLAVIN BIOSYNTHESIS (AT THE
FT SECOND AND THIRD STEPS). CONVERTS
FT 2,5-DIAMINO-6-(RIBOSYLAMINO)-4(3H)-PYRIMIDINONE
FT 5'-PHOSPHATE INTO
FT 5-AMINO-6-(RIBOSYLAMINO)-2,4(1H,3H)-PYRIMIDINEDIONE
FT 5'-PHOSPHATE [CATALYTIC ACTIVITY 1:
FT 2,5-DIAMINO-6-HYDROXY-4-(5-PHOSPHORIBOSYLAMINO)PYRIMIDINE +
FT H(2)O = 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NH(3)]
FT [CATALYTIC ACTIVITY 2:
FT 5-AMINO-6-(5-PHOSPHORIBITYLAMINO)URACIL + NADP(+) =
FT 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NADPH]."
FT /EC_number="3.5.4.26"
FT /EC_number="1.1.1.193"
FT /note="Rv1409, (MTCY21B4.26), len: 339 aa. Probable ribG
FT (alternate gene name: ribD), bifunctional riboflavin
FT biosynthesis protein, including
FT diaminohydroxyphosphoribosylaminopyrimidine deaminase and
FT 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC
FT 3.5.4.26 and 1.1.1.193), similar to many e.g.
FT RIBD_ECOLI|P25539 riboflavin-specific deaminase from
FT Escherichia coli (367 aa), FASTA scores: E(): 0, (39.8%
FT identity in 364 aa overlap); etc. Contains PS00903 Cytidine
FT and deoxycytidylate deaminases zinc-binding region
FT signature. IN THE N-TERMINAL SECTION; BELONGS TO THE
FT CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. IN THE
FT C-TERMINAL SECTION; BELONGS TO THE HTP REDUCTASE FAMILY."
FT /db_xref="GOA:P71677"
FT /db_xref="InterPro:IPR002125"
FT /db_xref="InterPro:IPR002734"
FT /db_xref="InterPro:IPR004794"
FT /db_xref="InterPro:IPR011549"
FT /db_xref="InterPro:IPR016192"
FT /db_xref="InterPro:IPR016193"
FT /db_xref="UniProtKB/Swiss-Prot:P71677"
FT /protein_id="CAB02188.1"
FT /translation="MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIV
FT GAGGTEPAGGDHAEVVALRRAGGLAAGAIVVVTMEPCNHYGKTPPCVNALIEARVGTVV
FT YAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKYATS
FT IDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAP
FT QQPLRVVVGKRDIPPEARVLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAF
FT LRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR"
FT misc_feature 202319..202435
FT /note="PS00903 Cytidine and deoxycytidylate deaminases
FT zinc-binding region signature"
FT CDS complement(203167..204723)
FT /transl_table=11
FT /locus_tag="Rv1410c"
FT /standard_name="P55"
FT /product="AMINOGLYCOSIDES/TETRACYCLINE-TRANSPORT INTEGRAL
FT MEMBRANE PROTEIN"
FT /function="INVOLVED IN TRANSPORT OF AMINOGLYCOSIDES AND
FT TETRACYCLINE ACROSS THE MEMBRANE (EXPORT): DRUG RESISTANCE
FT BY AN EXPORT MECHANISM (CONFERES RESISTANCE TO TOXIC
FT COMPOUNDS BY REMOVING THEM FOR THE CELLS). RESPONSIBLE FOR
FT THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE."
FT /note="Rv1410c, (MTCY21B4.27c), len: 518 aa.
FT Aminoglycoside/tetracycline-transport integral membrane
FT protein (see citation below), member of major facilitator
FT superfamily (MFS), similar to others e.g. AC22_STRCO|P46105
FT probable actinorhodin transporter from Streptomyces
FT coelicolor (578 aa), FASTA scores: opt: 442, E(): 4.9e-21,
FT (28.5% identity in 466 aa overlap); etc. Contains PS00216
FT Sugar transport proteins signature 1. Could be termed P55.
FT Note that the Rv1410c-Rv1411c operon seems transcribed from
FT two promoters in Mycobacterium bovis BCG (see Bigi et al.,
FT 2000)."
FT /db_xref="GOA:P71678"
FT /db_xref="InterPro:IPR005829"
FT /db_xref="InterPro:IPR011701"
FT /db_xref="InterPro:IPR016196"
FT /db_xref="UniProtKB/TrEMBL:P71678"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02189.1"
FT /translation="MRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMNSVGIPINQLH
FT RITWIVTMYLLGYIAAMPLLGRASDRFGRKLMLQVSLAGFIIGSVVTALAGHFGDFHML
FT IAGRTIQGVASGALLPITLALGADLWSQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWL
FT LHDWRDVFWINVPLTAIAMVMIHFSLPSHDRSTEPERVDLVGGLLLALALGLAVIGLYN
FT PNPDGKHVLPDYGAPLLVGALVAAVAFFGWERFARTRLIDPAGVHFRPFLSALGASVAA
FT GAALMVTLVDVELFGQGVLQMDQAQAAGMLLWFLIALPIGAVTGGWIATRAGDRAVAFA
FT GLLIAAYGYWLISHWPVDLLADRHNILGLFTVPAMHTDLVVAGLGLGLVIGPLSSATLR
FT VVPSAQHGIASAAVVVARMTGMLIGVAALSAWGLYRFNQILAGLSAAIPPNASLLERAA
FT AIGARYQQAFALMYGEIFTITAIVCVFGAVLGLLISGRKEHADEPEVQEQPTLAPQVEP
FT L"
FT misc_feature complement(204481..204531)
FT /note="PS00216 Sugar transport proteins signature 1"
FT CDS complement(204729..205439)
FT /transl_table=11
FT /gene="lprG"
FT /locus_tag="Rv1411c"
FT /standard_name="P27"
FT /product="PROBABLE CONSERVED LIPOPROTEIN LPRG"
FT /function="UNKNOWN"
FT /note="Rv1411c, (MTCY21B4.28c), len: 236. Probable lprG
FT (alternate gene name: P27), conserved lipoprotein, similar
FT to Mycobacterium tuberculosis hypothetical lipoproteins
FT e.g. Rv1270c|MTCY50.12 (35.1% identity in 245 aa overlap);
FT Rv1368, Rv2945c. Contains N-terminal signal sequence and
FT appropriately positioned prokaryotic lipoprotein lipid
FT attachment site (PS00013). Note that the Rv1410c-Rv1411c
FT operon seems transcribed from two promoters in
FT Mycobacterium bovis BCG (see Bigi et al., 2000)."
FT /db_xref="GOA:P0A5I8"
FT /db_xref="InterPro:IPR009830"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5I8"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02197.1"
FT /translation="MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLV
FT EEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADF
FT VVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQ
FT NTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLS
FT KWGEKVQVTKPPVS"
FT CDS 205524..206129
FT /transl_table=11
FT /gene="ribC"
FT /locus_tag="Rv1412"
FT /product="PROBABLE RIBOFLAVIN SYNTHASE ALPHA CHAIN RIBC
FT (RIBE)"
FT /function="INVOLVED IN RIBOFLAVIN SYNTHESIS. RIBOFLAVIN
FT SYNTHASE IS A BIFUNCTIONAL ENZYME COMPLEX CATALYZING THE
FT FORMATION OF RIBOFLAVIN FROM 5-AMINO-6-(1'-D)-
FT RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE AND
FT L-3,4-DIHYDROHY-2- BUTANONE-4-PHOSPHATE VIA
FT 6,7-DIMETHYL-8-LUMAZINE. THE ALPHA SUBUNIT CATALYZES THE
FT DISMUTATION OF 6,7-DIMETHYL-8-LUMAZINE TO RIBOFLAVIN AND
FT 5-AMINO-6-(1'-D)-RIBITYL-AMINO-2,4(1H,3H)-
FT PYRIMIDINEDIONE."
FT /EC_number="2.5.1.9"
FT /note="Rv1412, (MTCY21B4.29), len: 201 aa. Probable ribC
FT (ribE), Riboflavin synthase alpha chain (EC 2.5.1.9),
FT strong similarity to e.g. RISA_ACTPL|P50854 (215 aa), FASTA
FT scores: opt: 586, E(): 1.8e-33, (50.8% identity in 197 aa
FT overlap). Contains 2 x PS00693 Riboflavin synthase alpha
FT chain family signature."
FT /db_xref="GOA:P65327"
FT /db_xref="InterPro:IPR001783"
FT /db_xref="InterPro:IPR017938"
FT /db_xref="UniProtKB/Swiss-Prot:P65327"
FT /protein_id="CAB02162.1"
FT /translation="MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNG
FT VCLTVVDVLPDGQFTADVMAETLNRSNLGELRPGSRVNLERAAALGSRLGGHIVQGHVD
FT ATGEIVARCPSEHWEVVRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFEVSL
FT IPTTRELTTLGSAAVGTRVNLEVDVVAKYVERLMRSAG"
FT misc_feature 205740..205778
FT /note="PS00693 Riboflavin synthase alpha chain family
FT signature"
FT misc_feature 206040..206078
FT /note="PS00693 Riboflavin synthase alpha chain family
FT signature"
FT CDS 206343..206858
FT /transl_table=11
FT /locus_tag="Rv1413"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1413, (MTCY21B4.30), len: 171 aa. Conserved
FT hypothetical protein, similar to part of
FT AB010956|AB010956_1 metal-activated pyridoxal enzyme from
FT Arthrobacter sp. (379 aa), FASTA scores: opt: 187, E():
FT 0.00026, (29.0% identity in 162 aa overlap)."
FT /db_xref="InterPro:IPR001608"
FT /db_xref="UniProtKB/Swiss-Prot:P64843"
FT /protein_id="CAB02198.1"
FT /translation="MATIGEVEVFVDHGADDVFITYPLWIGTRQADRLRQLADRARIAV
FT GAGTAEGASNTGARLADAAGAIDVLIEIDSGHHRSGVRAEQVLEVAHAVGEAGLHLVGV
FT FTFPGHSYAPGKPGEAGEQERRALNDAANALVAVGFPISCRSGGSTPTALLTAADGASE
FT TSRRLCAR"
FT CDS 206848..207249
FT /transl_table=11
FT /locus_tag="Rv1414"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1414, (MTCY21B4.31), len: 133 aa. Conserved
FT hypothetical protein, similar to C-terminal part of
FT AB010956|AB010956_1 novel metal-activated pyridoxal enzyme
FT from Arthrobacter sp. (379 aa), FASTA scores: opt: 163,
FT E(): 0.00063, (32.1% identity in 112 aa overlap). Rv1413 is
FT similar to N-terminal part of same enzyme suggesting
FT possible frameshift. Sequence has been checked and no
FT errors found, it is identical in Mycobacterium bovis strain
FT AF2122/97 and in Mycobacterium tuberculosis CDC1551."
FT /db_xref="UniProtKB/Swiss-Prot:P64845"
FT /protein_id="CAB02163.1"
FT /translation="MLGDAQQLELGRCAPADIALTVAATVVSRQDCRSGLRRIVLDCGS
FT KILGSDRPAWATGFGRLIDHADARIAALSEHHATVVWPDDAPLPPVGTRLRVIPNHVCL
FT TTNLVDDVAVVRDATLIDRWKVAARGKNH"
FT CDS 207354..208631
FT /transl_table=11
FT /gene="ribA2"
FT /locus_tag="Rv1415"
FT /product="PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 :
FT GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone
FT 4-phosphate synthase (DHBP synthase)"
FT /function="INVOLVED IN RIBOFLAVIN BIOSYNTHESIS [CATALYTIC
FT ACTIVITY : GTP + 3 H(2)O = FORMATE +
FT 2,5-DIAMINO-6-HYDROXY-4-(5-PHOSPHORIBOSYLAMINO)PYRIMIDINE +
FT DIPHOSPHATE]."
FT /EC_number="3.5.4.25"
FT /note="Rv1415, (MTCY21B4.33), len: 428 aa. Probable ribA2,
FT Riboflavin biosynthesis protein (EC 3.5.4.25), similar to
FT many e.g. GCH2_BACSU|P17620 Bacillus subtilis (398 aa),
FT FASTA scores: opt: 1388, E(): 0, (55.4% identity in 399 aa
FT overlap). Also similar to second Mycobacterium tuberculosis
FT gtp cyclohydrolase Rv1940|ribA1 (353 aa). IN THE N-TERMINAL
FT SECTION; BELONGS TO THE DHBP SYNTHASE FAMILY. IN THE
FT C-TERMINAL SECTION; BELONGS TO THE GTP CYCLOHYDROLASE II
FT FAMILY."
FT /db_xref="GOA:P0A5V0"
FT /db_xref="InterPro:IPR000422"
FT /db_xref="InterPro:IPR000926"
FT /db_xref="InterPro:IPR016299"
FT /db_xref="InterPro:IPR017945"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5V0"
FT /protein_id="CAB02199.1"
FT /translation="MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEM
FT VAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGIGTGISASD
FT RATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAI
FT CEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHG
FT EFRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQL
FT DAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARD
FT YGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRD
FT KLGHDLAGLDDFHESVHLPGEFGGAL"
FT CDS 208646..209110
FT /transl_table=11
FT /gene="ribH"
FT /locus_tag="Rv1416"
FT /product="PROBABLE RIBOFLAVIN SYNTHASE BETA CHAIN RIBH
FT (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase)
FT (Lumazine synthase)"
FT /function="RIBOFLAVIN SYNTHASE IS A BIFUNCTIONAL ENZYME
FT COMPLEX INVOLVED IN RIBOFLAVIN SYNTHESIS. RIBOFLAVIN
FT SYNTHASE CATALYZES THE FORMATION OF RIBOFLAVIN FROM
FT 5-AMINO-6-(1'-D)- RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE
FT AND L-3,4-DIHYDROHY-2- BUTANONE-4-PHOSPHATE VIA
FT 6,7-DIMETHYL-8-LUMAZINE. THE BETA SUBUNIT CATALYZES THE
FT CONDENSATION OF 5-AMINO-6-(1'-D)-RIBITYL-
FT AMINO-2,4(1H,3H)-PYRIMIDINEDIONE WITH
FT L-3,4-DIHYDROHY-2-BUTANONE- 4-PHOSPHATE YIELDING
FT 6,7-DIMETHYL-8-LUMAZINE."
FT /EC_number="2.5.1.9"
FT /note="Rv1416, (MTCY21B4.34), len: 154 aa. Probable ribH,
FT riboflavin synthase beta chain (EC 2.5.1.9), similar to
FT many e.g. RISB_ECOLI|P25540 Escherichia coli (156 aa),
FT FASTA scores: opt: 330, E(): 1.8e-15, (44.1% identity in
FT 145 aa overlap). Note alternative GTG start possible
FT overlapping the stop codon of Rv1415|MTCY21B4.33. BELONGS
FT TO THE DMRL SYNTHASE FAMILY."
FT /db_xref="GOA:P66034"
FT /db_xref="InterPro:IPR002180"
FT /db_xref="PDB:1W19"
FT /db_xref="PDB:1W29"
FT /db_xref="PDB:2C92"
FT /db_xref="PDB:2C94"
FT /db_xref="PDB:2C97"
FT /db_xref="PDB:2C9B"
FT /db_xref="PDB:2C9D"
FT /db_xref="PDB:2VI5"
FT /db_xref="UniProtKB/Swiss-Prot:P66034"
FT /protein_id="CAB02164.1"
FT /translation="MPDLPSLDASGVRLAIVASSWHGKICDALLDGARKVAAGCGLDDP
FT TVVRVLGAIEIPVVAQELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDSST
FT PIANGVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLRELRAHS"
FT CDS 209107..209571
FT /transl_table=11
FT /locus_tag="Rv1417"
FT /product="POSSIBLE CONSERVED MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1417, (MTCY21B4.35), len: 154 aa. Possible
FT conserved membrane protein, similar to others e.g.
FT AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA
FT scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa
FT overlap)."
FT /db_xref="GOA:P64847"
FT /db_xref="InterPro:IPR019692"
FT /db_xref="UniProtKB/Swiss-Prot:P64847"
FT /protein_id="CAB02165.1"
FT /translation="MTAAPNDWDVVLRPHWTPLFAYAAAFLIAVAHVAGGLLLKVGSSG
FT VVFQTADQVAMGALGLVLAGAVLLFARPRLRVGSAGLSVRNLLGDRIVGWSEVIGVSFP
FT GGSRWARIDLADDEYIPVMAIQAVDKDRAVAAMDTVRSLLARYRPDLCAR"
FT CDS 209596..210282
FT /transl_table=11
FT /gene="lprH"
FT /locus_tag="Rv1418"
FT /product="PROBABLE LIPOPROTEIN LPRH"
FT /function="UNKNOWN"
FT /note="Rv1418, (MTCY21B4.36), len: 228 aa. Probable lprH,
FT lipoprotein. Contains N-terminal signal sequence and
FT appropriately positioned prokaryotic lipoprotein lipid
FT attachment site (PS00013)."
FT /db_xref="GOA:P65316"
FT /db_xref="UniProtKB/Swiss-Prot:P65316"
FT /protein_id="CAB02166.1"
FT /translation="MACLGRPGCRGWAGASLVLVVVLALAACTESVAGRAMRATDRSSG
FT LPTSAKPARARDLLLQDGDRAPFGQVTQSRVGDSYFTSAVPPECSAALLFKGSPLRPDG
FT SSDHAEAAYNVTGPLPYAESVDVYTNVLNVHDVVWNGFRDVSHCRGDAVGVSRAGRSTP
FT MRLRYFATLSDGVLVWTMSNPRWTCDYGLAVVPHAVLVLSACGFKPGFPMAEWASKRRA
FT QLDSQV"
FT CDS 210462..210935
FT /transl_table=11
FT /locus_tag="Rv1419"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1419, (MTCY21B4.37), len: 157 aa. Hypothetical
FT unknown protein."
FT /db_xref="GOA:P64849"
FT /db_xref="InterPro:IPR000772"
FT /db_xref="InterPro:IPR008997"
FT /db_xref="UniProtKB/Swiss-Prot:P64849"
FT /protein_id="CAB02167.1"
FT /translation="MGELRLVGGVLRVLVVVGAVFDVAVLNAGAASADGPVQLKSRLGD
FT VCLDAPSGSWFSPLVINPCNGTDFQRWNLTDDRQVESVAFPGECVNIGNALWARLQPCV
FT NWISQHWTVQPDGLVKSDLDACLTVLGGPDPGTWVSTRWCDPNAPDQQWDSVP"
FT CDS 210999..212939
FT /transl_table=11
FT /gene="uvrC"
FT /locus_tag="Rv1420"
FT /product="PROBABLE EXCINUCLEASE ABC (SUBUNIT C-NUCLEASE)
FT UVRC"
FT /function="INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC
FT EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE
FT EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS
FT PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). ATTACHES
FT TO THE UVRA-UVRB COMPLEX, DISPLACING UVRA, AND THE DAMAGED
FT DNA STRAND IS NICKED ON BOTH SIDES OF THE DAMAGED SITE"
FT /note="Rv1420, (MTCY21B4.38), len: 646 aa. Probable uvrC,
FT excinuclease ABC, subunit C; nuclease (see citations
FT below), similar to many e.g. UVRC_PSEFL|P32966 Pseudomonas
FT fluorescens (607 aa), fasta scores: opt: 738, E(): 8.4e-39,
FT (36.6% identity in 629 aa overlap). BELONGS TO THE UVRC
FT FAMILY."
FT /db_xref="GOA:P67426"
FT /db_xref="InterPro:IPR000305"
FT /db_xref="InterPro:IPR000445"
FT /db_xref="InterPro:IPR001162"
FT /db_xref="InterPro:IPR001943"
FT /db_xref="InterPro:IPR003583"
FT /db_xref="InterPro:IPR004791"
FT /db_xref="InterPro:IPR009055"
FT /db_xref="InterPro:IPR010994"
FT /db_xref="UniProtKB/Swiss-Prot:P67426"
FT /protein_id="CAB02168.1"
FT /translation="MPDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTS
FT YFADVASLAPRTRQLVTTAAKVEWTVVGTEVEALQLEYTWIKEFDPRFNVRYRDDKSYP
FT VLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVFKR
FT HRQIDRPCLLGYIDKCSAPCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAA
FT EQLDFERAARLRDDLSALKRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRV
FT RGQRGWIVEKPGEPGDSGIQLVEQFLTQFYGDQAALDDAADESANPVPREVLVPCLPSN
FT AEELASWLSGLRGSRVVLRVPRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAAL
FT QSIQDSLGLADAPLRIECVDVSHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGR
FT SDDVACIAEVTRRRFLRHLRDQSDPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAV
FT IDELGVTDVAVIGLAKRLEEVWVPSEPDPIIMPRNSEGLYLLQRVRDEAHRFAITYHRS
FT KRSTRMTASALDSVPGLGEHRRKALVTHFGSIARLKEATVDEITAVPGIGVATATAVHD
FT ALRPDSSGAAR"
FT CDS 212936..213841
FT /transl_table=11
FT /locus_tag="Rv1421"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1421, (MTCY21B4.39), len: 301 aa. Conserved
FT hypothetical protein, similar to many hypothetical proteins
FT e.g. YHBJ_ECOLI|P33995 hypothetical 32.5 kd protein from
FT Escherichia coli (284 aa), FASTA scores: opt: 648, E():
FT 6.3e-36, (38.7% identity in 282aa overlap)."
FT /db_xref="GOA:P67106"
FT /db_xref="InterPro:IPR005337"
FT /db_xref="UniProtKB/Swiss-Prot:P67106"
FT /protein_id="CAB02169.1"
FT /translation="MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVA
FT DNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFM
FT EASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLR
FT DSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPA
FT VRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMG
FT LLRSDQQLSVRALHRDLGRE"
FT CDS 213838..214866
FT /transl_table=11
FT /locus_tag="Rv1422"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1422, (MTCY21B4.40), len: 342 aa. Conserved
FT hypothetical protein, similar to many hypothetical proteins
FT e.g. YAMB_THETU|P38541 Thermoanaerobacterium
FT thermosulfurigenes (323 aa), FASTA scores: opt: 519, E():
FT 1.6e-25, (33.1% identity in 320 aa overlap); and
FT AF106003|AF106003_3 Streptomyces coelicolor (363 aa), FASTA
FT scores: opt: 1047, E(): 0, (54.5% identity in 308 aa
FT overlap)."
FT /db_xref="InterPro:IPR002882"
FT /db_xref="InterPro:IPR010119"
FT /db_xref="UniProtKB/Swiss-Prot:P71691"
FT /protein_id="CAB02170.1"
FT /translation="MTDGIVALGGGHGLYATLSAARRLTPYVTAVVTVADDGGSSGRLR
FT SELDVVPPGDLRMALAALASDSPHGRLWATILQHRFGGSGALAGHPIGNLMLAGLSEVL
FT ADPVAALDELGRILGVKGRVLPMCPVALQIEADVSGLEADPRMFRLIRGQVAIATTPGK
FT VRRVRLLPTDPPATRQAVDAIMAADLVVLGPGSWFTSVIPHVLVPGLAAALRATSARRA
FT LVLNLVAEPGETAGFSVERHLHVLAQHAPGFTVHDIIIDAERVPSEREREQLRRTATML
FT QAEVHFADVARPGTPLHDPGKLAAVLDGVCARDVGASEPPVAATQEIPIDGGRPRGDDA
FT WR"
FT CDS 214863..215840
FT /transl_table=11
FT /gene="whiA"
FT /locus_tag="Rv1423"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIA"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1423, (MTCY21B4.41-MTCY493.31c), len: 325 aa.
FT Putative whiA, transcriptional regulator, probably
FT equivalent to AL035591|SCC54.10 whiA protein from
FT Streptomyces coelicolor (328 aa), FASTA scores: opt: 1505,
FT E(): 0, (70.4% identity in 324 aa overlap). Also some
FT similarity to O06975|YVCL hypothetical protein from
FT Bacillus subtilis (316 aa), FASTA scores: E(): 1.8e-0 8,
FT (25.7% identity in 304 aa overlap)."
FT /db_xref="GOA:P71692"
FT /db_xref="InterPro:IPR003802"
FT /db_xref="InterPro:IPR018478"
FT /db_xref="UniProtKB/Swiss-Prot:P71692"
FT /protein_id="CAB02171.1"
FT /translation="MTTDVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVGGRVVVEA
FT ELDLGSIARRLRKEIFELYGYTAVVHVLSASGIRKSTRYVLRVANDGEALARQTGLLDM
FT RGRPVRGLPAQVVGGSIDDAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGA
FT ARRLGVGAKAREVRGADRVVVRDGEAIGALLTRMGAQDTRLVWEERRLRREVRATANRL
FT ANFDDANLRRSARAAVAAAARVERALEILGDTVPEHLASAGKLRVEHRQASLEELGRLA
FT DPPMTKDAVAGRIRRLLSMADRKAKVDGIPDTESVVTPDLLEDA"
FT CDS complement(215850..216611)
FT /transl_table=11
FT /locus_tag="Rv1424c"
FT /product="POSSIBLE MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1424c, (MTCY21B4.42c,MTCY493.30), len: 253 aa.
FT Possible membrane protein, contains PS00402
FT Binding-protein-dependent transport systems inner membrane
FT comp signature."
FT /db_xref="UniProtKB/Swiss-Prot:P64851"
FT /protein_id="CAB09246.1"
FT /translation="MTVVPGAPSRPASAVSRPSYRQCVQASAQTSARRYSFPSYRRPPA
FT EKLVFPVLLGILTLLLSACQTASASGYNEPRGYDRATLKLVFSMDLGMCLNRFTYDSKL
FT APSRPQVVACDSREARIRNDGFHANAPSCMRIDYELITQNHRAYYCLKYLVRVGYCYPA
FT VTTPGKPPSVLLYAPSACDESLPSPRVATALVPGTRSANREFSRFVVTEIKSLGAGGRC
FT DSASVSLQPPEEIEGPAIPPASSQLVCVAPK"
FT misc_feature complement(216360..216446)
FT /note="PS00402 Binding-protein-dependent transport systems
FT inner membrane comp signature"
FT CDS 216615..217994
FT /transl_table=11
FT /locus_tag="Rv1425"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1425, (MTCY21B4.43,MTCY493.29c), len: 459 aa.
FT Conserved hypothetical protein, similar to many M.
FT tuberculosis hypothetical proteins e.g. Rv3740c, Rv3734c,
FT Rv1760, etc."
FT /db_xref="InterPro:IPR004255"
FT /db_xref="InterPro:IPR014292"
FT /db_xref="UniProtKB/Swiss-Prot:P71694"
FT /protein_id="CAB09245.1"
FT /translation="MKRLSSVDAAFWSAETAGWHMHVGALAICDPSDAPEYSFQRLREL
FT IIERLPEIPQLRWRVTGAPLGLDRPWFVEDEELDIDFHIRRIGVPAPGGRRELEELVGR
FT LMSYKLDRSRPLWELWVIEGVEGGRIATLTKMHHAIVDGVSGAGLGEILLDITPEPRPP
FT QQETVGFVGFQIPGLERRAIGALINVGIMTPFRIVRLLEQTVRQQIAALGVAGKPARYF
FT EAPKTRFNAPVSPHRRVTGTRVELARAKAVKDAFGVKLNDVVLALVAGAARQYLQKRDE
FT LPAKPLIAQIPVSTRSEETKADVGNQVSSMTASLATHIEDPAKRLAAIHESTLSAKEMA
FT KAPSAHQIMGLTETTPPGLLQLAARAYTASGLSHNLAPINLVVSNVPGPPFPLYMAGAR
FT LDSLVPLGPPVMDVALNITCFSYQDYLDFGLVTTPEVANDIDEMADAIEPALAELERAA
FT E"
FT CDS complement(218016..219278)
FT /transl_table=11
FT /gene="lipO"
FT /locus_tag="Rv1426c"
FT /product="PROBABLE ESTERASE LIPO"
FT /function="UNKNOWN, BUT SUPPOSED INVOLVED IN LIPID
FT METABOLISM"
FT /EC_number="3.1.-.-"
FT /note="Rv1426c, (MTCY493.28), len: 420 aa. Possible Lipo,
FT esterase (EC 3.1.-.-), similar to several Mycobacterium
FT tuberculosis hypothetical lipases and esterases e.g.
FT Rv1399c, Rv2284, etc. Also similar in central region to
FT AAAD_HUMAN|P22760 human arylacetamide deacetylase (398 aa),
FT FASTA scores: opt:210, E(): 7.6e-07, (29.3% identity in 191
FT aa overlap)."
FT /db_xref="GOA:O06832"
FT /db_xref="InterPro:IPR002018"
FT /db_xref="InterPro:IPR013094"
FT /db_xref="UniProtKB/TrEMBL:O06832"
FT /protein_id="CAB09244.1"
FT /translation="MRFRRMARPRPLTRAAVELLNAANGLRPLSGSGYSTVLAFWLGWP
FT TSEVPGVYLGASVLDALRRGRRGDFGGLKGKAALALTAAAWVILAVIRYRGATTPGPVL
FT EAGLTEQLGPDYAKELATLPTEPMRSRGRNLPLRTAMARRRYVETTNVVCYGPYGRANL
FT ADIWRRRDLPRDAKAPVLVQVPGGAWVLGWRRPQAYPLMSHLAARGWVCVSLNYRVSPR
FT HTWPDHIVDVKRALAWVKENIAAYGGDPNFVAISGGSAGGHLCALAALTPNDPRFQPGF
FT EQVDTSVAAAVPVYGRYDWFTTDAPGRREFVGLLETFVVKRKFSTHRDIFVDASPIHHV
FT RADAPPFFVLHGRHDSLIPVAEAHAFVEELRAVSKSPVAYADLPHAQHAFDVFGSPRAH
FT HTAEAVARFLSWVYATNPPAT"
FT CDS complement(219278..220885)
FT /transl_table=11
FT /gene="fadD12"
FT /locus_tag="Rv1427c"
FT /product="POSSIBLE LONG-CHAIN-FATTY-ACID--CoA LIGASE FADD12
FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)"
FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID
FT DEGRADATION."
FT /EC_number="6.2.1.-"
FT /note="Rv1427c, (MTCY493.27), len: 535 aa. Possible fadD12,
FT long-chain-fatty-acid-CoA synthetase (EC 6.2.1.-), similar
FT to many e.g. NP_302632.1|NC_002677 acyl-CoA synthase from
FT Mycobacterium leprae (548 aa); AAD01929.2|AF031419 putative
FT long-chain-fatty-acid--CoA ligase from Pseudomonas putida
FT (565 aa); NP_419782.1|NC_002696 putative
FT long-chain-fatty-acid--CoA ligase from Caulobacter
FT crescentus (530 aa); PC60_YEAST|P38137 yeast
FT peroxisomal-coenzyme A synthetase (543 aa), FASTA scores:
FT opt: 507, E(): 2.9e-25, (30.4% identity in 365 aa overlap).
FT Also similar to many M. tuberculosis proteins e.g.
FT MTCY06A4.14 (44.8% identity in 525 aa overlap). Contains
FT PS00455 Putative AMP-binding domain signature. BELONGS TO
FT THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY."
FT /db_xref="GOA:O06831"
FT /db_xref="HSSP:1LCI"
FT /db_xref="InterPro:IPR000873"
FT /db_xref="InterPro:IPR020845"
FT /db_xref="UniProtKB/TrEMBL:O06831"
FT /protein_id="CAB09257.1"
FT /translation="MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAGF
FT AGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAGPPRVVGIMCRNHRGFVD
FT ALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVYDEEFSATVDRALAEKPQATRI
FT VAWTDEDHDLTVEKLVAAHAGRRPEHTGSHGKVILLTSGTTGTPKGARHSGGGIGTLKA
FT ILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRRRFDPEATLDLIDRHHAT
FT GLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPDVVIAFMDQFGDVIYNNYN
FT ATEAGMIATATPADLRTAPDTAGRPAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDG
FT YTSGAAKDFHAGFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPD
FT VAEAAVIGVDDQQYGQRLAAFVVLKPGVSATPETLKQHVRDNLANYKVPRDIAVLDELP
FT RGITGKILRTELQSRVGS"
FT misc_feature complement(220262..220297)
FT /note="PS00455 Putative AMP-binding domain signature"
FT CDS complement(220889..221716)
FT /transl_table=11
FT /locus_tag="Rv1428c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1428c, (MTCY493.26), len: 275 aa. Conserved
FT hypothetical protein, some similarity to hypothetical
FT proteins from Mycobacterium tuberculosis e.g.
FT Rv0502|YV29_MYCTU|Q11167 (358 aa), FASTA scores: opt: 355,
FT E(): 5e-16, (32.6% identity in 273 aa overlap); and
FT Rv1920."
FT /db_xref="GOA:O06830"
FT /db_xref="InterPro:IPR002123"
FT /db_xref="InterPro:IPR016676"
FT /db_xref="UniProtKB/TrEMBL:O06830"
FT /protein_id="CAB09256.1"
FT /translation="MSETDSPGNGDDAGIGDIGKFDPGLTQRLISVLRPVLKTYHRSQV
FT HGLDSFPPGGALVVANHSGGMFPMDVPVFSVDFYDKFGYDRPVYTLSHDILFMGLTGDL
FT FRRTGYIRATRENAAKALRSGGVVVVFPGGDYDAYRPTFAENVIDFNGRKGYVSTAVEA
FT GVPIVPAVSIGGQESQLYLSRGTWLARRLGLKRLLRSDILPISFGFPFGFSAAIPPNLP
FT LPAKIVMQVLDPINLTKQFGEDPDVDAVDEHVRSVMQQALNDLAAKRRFPILG"
FT CDS 221835..223103
FT /transl_table=11
FT /locus_tag="Rv1429"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1429, (MTCY493.25c), len: 422 aa. Conserved
FT hypothetical protein, some similarity to transcriptional
FT regulator proteins e.g. CDAR_ECOLI|P37047 Carbohydrate
FT diacid regulator from Escherichia coli (391 aa), FASTA
FT scores: opt: 210, E(): 3e-06, (27.7% identity in 296 aa
FT overlap). Also similar to Mycobacterium tuberculosis
FT hypothetical proteins Rv2370c, Rv1194c, Rv1453, Rv2242, and
FT Rv1186c."
FT /db_xref="UniProtKB/TrEMBL:O06829"
FT /protein_id="CAB09255.1"
FT /translation="MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMA
FT DLWRASITENFVTAVHYLDRDTPQSLVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHA
FT RFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQ
FT QQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAG
FT ELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVGD
FT GLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGD
FT LSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDA
FT AFRVQMALEVCRWMAPAVLRAKQ"
FT CDS 223343..224929
FT /transl_table=11
FT /gene="PE16"
FT /locus_tag="Rv1430"
FT /product="PE FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1430, (MTCY493.24c), len: 528 aa. Member of the
FT Mycobacterium tuberculosis PE family of proteins (see
FT citation below), e.g. Y0D4_MYCTU|Q50594 (55.9% identity in
FT 127 aa overlap). The C-terminus shows similarity to
FT Q49633|LEPB1170_F3_112 hypothetical Mycobacterium leprae
FT protein (391 aa), FASTA scores: opt: 342, E(): 1.2e-13,
FT (29.8% identity in 292 aa overlap). Possible TMhelix aa
FT 500-522."
FT /db_xref="InterPro:IPR000084"
FT /db_xref="InterPro:IPR013228"
FT /db_xref="UniProtKB/TrEMBL:Q7D8G5"
FT /protein_id="CAE55388.1"
FT /translation="MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAAD
FT EVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVDTAATG
FT ASELGSGGRTALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWTGI
FT PSLTYDQSVAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAPS
FT PDQLSFVLLGNPNNPNGGILARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYDGFADF
FT PKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIVLPVSSPDTNTTYILLPNEDLPL
FT LQPLRGIVPEPLLDLIEPDLRAIIELGYDRTGYADVPTPAALFPVHIDPIAVPPQIGAA
FT IGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVL
FT PILVEGPGALVTADTHYLVDAIQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAA
FT VAILTGQDFPV"
FT CDS 225040..226809
FT /transl_table=11
FT /locus_tag="Rv1431"
FT /product="CONSERVED MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1431, (MTCY493.23c), len: 589 aa. Conserved
FT membrane protein, shows strong similarity to another M.
FT tuberculosis hypothetical protein Rv1132|MTCY22G8.21 (48.2%
FT identity in 585 aa overlap)."
FT /db_xref="UniProtKB/TrEMBL:O06827"
FT /protein_id="CAB09253.1"
FT /translation="MGFLKPDLPDVDHDTWLTQPRRTRLQVVTRDWVEHGFGTPYAVYL
FT LYLTKIAVYVAAGAAIISLNPGLGGLSRIGDWWTQPIVYQKVIVFTLLFEVLGFGCGSG
FT PLTGRFWPPIGGFLYWLRPNTIRLPAWPDKVPFTQGDTRTVVDVALYAIVLIGGVWALL
FT SPGSPGPGGTPVTAAGDVGLINPVLVVPTIVALGVLGLRDKTIFLAARGEHYWLKLFVF
FT FFPFTDQIAAFKIIMLCLWWGAATSKLNHHFPYVVAVMTSNNALLRSRVFNPIKHLLYR
FT DHANDLRPSWLPKLMAHGGGTTAEFLVPGILVLVADGHPWRWFLIGFMVLFHLNILSNL
FT PMGVPLEWNVFFIFSLCYLFGHYGAITATDLRSPLLLAIVIAVVAVVIMGNLLPEKISF
FT LPAMRYYAGNWATSIWCFRGDAEATMETSVVKSSALVVNQLAKLYDGATAEIMTDKVAA
FT FRAMHTHGRALNGLLPRALDDEAHYRIREGEIVAGPLVGWNFGEGHLHNEQLVAAVQRR
FT CNFADGDLRVIILEGQPIHVQKQWYRIVDAKTGLFEAGYVTVEDMLSRQPWPEPGDEFP
FT VHVTTQRGTPSKP"
FT CDS 226806..228227
FT /transl_table=11
FT /locus_tag="Rv1432"
FT /product="PROBABLE DEHYDROGENASE"
FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT METABOLISM"
FT /EC_number="1.-.-.-"
FT /note="Rv1432, (MTCY493.22c), len: 473 aa. Probable
FT dehydrogenase (EC 1.-.-.-), shows strong simlarity to
FT P49_STRLI|P06108 p49 protein from Streptomyces lividans
FT (469 aa), FASTA scores: opt: 1362, E(): 0, (44.9% identity
FT in 474 aa overlap); and weak simlarity to other
FT dehydrogenases."
FT /db_xref="GOA:O06826"
FT /db_xref="InterPro:IPR006076"
FT /db_xref="InterPro:IPR013027"
FT /db_xref="UniProtKB/TrEMBL:O06826"
FT /protein_id="CAB09252.1"
FT /translation="MTTAVVVGAGPNGLAAAIHLARHGVDVQVLEARDTIGGGARSGEL
FT TVPGVIHDHCSAFHPLGVGSPFWAAIDLQRYGLTWKWPDVDCAHPLDDGTAGVLYRSIE
FT ATAAGLGPDGKRWQRAVGDLAAGFDELAEDLLRPVLNMPRHPIRLARFGPRAALPATAM
FT ARRFHTERARALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSITKAL
FT AAALDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTRINRSYRRYRA
FT GSSAFKVDFAIEGDVGWTNPDCRRAGTVHLGGTFAEIADTERQRAQGTMVQRPFVLVGQ
FT QYLADPSRSVGNINPIWAYAHVPFGYTGDATAAVIDQIERFAPGFRDRIVATVSTSTTE
FT LQTYNRNFIGGDIIGGANDRLQVIFRPRVAVDPYAIGVPGVYLCSQSAPPGAGIHGLCG
FT YHAAESALRWLRKRR"
FT CDS 228391..229206
FT /transl_table=11
FT /locus_tag="Rv1433"
FT /product="POSSIBLE CONSERVED EXPORTED PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1433, (MTCY493.21c), len: 271 aa. Possible
FT exported protein with N-terminal signal sequence, highly
FT similar to Q49706 hypothetical protein from Mycobacterium
FT leprae (271 aa), FASTA scores: opt: 1341, E(): 0, (68.3%
FT identity in 271 aa overlap). Also shows similarity to M.
FT tuberculosis lipoprotein Rv2518c|MTV009.03c lppS (408 aa)
FT (40.0% identity in 230 aa overlap); and others e.g.
FT Rv0116c, Rv0192, Rv2518c, Rv0483."
FT /db_xref="InterPro:IPR005490"
FT /db_xref="UniProtKB/TrEMBL:O06825"
FT /protein_id="CAB09251.1"
FT /translation="MRAVFGCAIAVVGIAGSVVAGPADIHLVAAKQSYGFAVASVLPTR
FT GQVVGVAHPVVVTFSAPITNPANRHAAERAVEVKSTPAMTGKFEWLDNDVVQWVPDRFW
FT PAHSTVELSVGSLSSDFKTGPAVVGVASISQHTFTVSIDGVEEGPPPPLPAPHHRVHFG
FT EDGVMPASMGRPEYPTPVGSYTVLSKERSVIMDSSSVGIPVDDPDGYRLSVDYAVRITS
FT RGLYVHSAPWALPALGLENVSHGCISLSREDAEWYYNAVDIGDPVIVQE"
FT CDS 229213..229350
FT /transl_table=11
FT /locus_tag="Rv1434"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1434, (MTCY493.20c), len: 45 aa. Hypothetical
FT unknown protein."
FT /db_xref="UniProtKB/TrEMBL:O06824"
FT /protein_id="CAB09250.1"
FT /translation="MRASPAERVDGAYAGAGPHTQSVLEEDQRQRAPAGAEAEGPGRTG
FT "
FT CDS complement(229299..229907)
FT /transl_table=11
FT /locus_tag="Rv1435c"
FT /product="Probable conserved Proline, Glycine, Valine-rich
FT secreted protein"
FT /function="UNKNOWN"
FT /note="Rv1435c, (MTCY493.19), len: 202 aa. Probable
FT conserved Pro-, Gly-, Val-rich secreted protein (see
FT citation below) with a N-terminal signal sequence. Similar
FT at C-terminus to AF017099|AF017099_1 Mycobacterium
FT tuberculosis pGB1 (87 aa), FASTA scores: opt: 550, E():
FT 2.3e-17, (97.7% identity in 86 aa overlap). Shows some
FT similarity to N-terminus of CPN_DROME|Q02910 calphotin.
FT drosophila melanogaster (865 aa), FASTA scores: opt: 266,
FT E(): 2.5e-05, (37.2% identity in 191 aa overlap). Contains
FT at least five 7 aa imperfect repeats. Also shows similarity
FT to other Mycobacterium tuberculosis proteins e.g.
FT MTCI237.20c (34.7% identity in 193 aa overlap), MTCI65.25c
FT (36.9% identity in 160 aa overlap) and MTCI65.24c (34.2%
FT identity in 196 aa overlap)."
FT /db_xref="UniProtKB/TrEMBL:O06823"
FT /protein_id="CAB09249.1"
FT /translation="MTLMAIVNRFNIKVIAGAGLFAAAIALSPDAAADPLMTGGYACIQ
FT GMAGDAPVAAGDPVAAGGPAAAGACSAALTDMAGVPFVAPGPVPAAAPVPIGAPVPIPG
FT APVPIPGAPVPIPGGPVPIPGAPVPVPAVPAPVIPVGTPLIALGPVLAGAPGDGVVSAP
FT IIGMSGVKDALTDPAPAGGPVPGQPVLPGPSASAPAGAR"
FT repeat_region complement(229515..229535)
FT /note="21 bp imperfect direct repeat 5,
FT GGCGCACCGGTACCGGTACCC"
FT repeat_region complement(229536..229556)
FT /note="21 bp imperfect direct repeat 4,
FT GGCGGACCGGTACCGATACCG"
FT repeat_region complement(229557..229577)
FT /note="21 bp imperfect direct repeat 3,
FT GGCGCACCGGTACCAATCCCC"
FT repeat_region complement(229578..229598)
FT /note="21 bp imperfect direct repeat 2,
FT GGCGCACCGGTACCGATACCG"
FT repeat_region complement(229599..229619)
FT /note="21 bp imperfect direct repeat 1,
FT GGCGCACCGGTACCAATCCCT"
FT CDS 230264..231283
FT /transl_table=11
FT /gene="gap"
FT /locus_tag="Rv1436"
FT /product="PROBABLE GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE
FT GAP (GAPDH)"
FT /function="INVOLVED IN SECOND PHASE OF GLYCOLYSIS (FIRST
FT STEP) [CATALYTIC ACTIVITY: D-GLYCERALDEHYDE 3-PHOSPHATE +
FT PHOSPHATE + NAD(+) = 3-PHOSPHO-D-GLYCEROYL PHOSPHATE +
FT NADH.]"
FT /EC_number="1.2.1.12"
FT /note="Rv1436, (MTCY493.18c), len: 339 aa. Probable gap,
FT Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12),
FT highly similar to many e.g. G3P_MYCLE|P46713 Mycobacterium
FT leprae (339 aa), FASTA scores: opt: 1933, E():0, (89.1%
FT identity in 339 aa overlap). Contains PS00071
FT Glyceraldehyde 3-phosphate dehydrogenase active site.
FT BELONGS TO THE GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE
FT FAMILY."
FT /db_xref="GOA:P64178"
FT /db_xref="InterPro:IPR000173"
FT /db_xref="InterPro:IPR006424"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="InterPro:IPR020828"
FT /db_xref="InterPro:IPR020829"
FT /db_xref="InterPro:IPR020830"
FT /db_xref="InterPro:IPR020831"
FT /db_xref="InterPro:IPR020832"
FT /db_xref="UniProtKB/Swiss-Prot:P64178"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB09248.1"
FT /translation="MTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNST
FT LAHLLKFDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVVVEST
FT GLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTTNCL
FT APLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAI
FT GLVMPQLKGKLDGYALRVPIPTGSVTDLTVDLSTRASVDEINAAFKAAAEGRLKGILKY
FT YDAPIVSSDIVTDPHSSIFDSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL"
FT misc_feature 230729..230752
FT /note="PS00071 Glyceraldehyde 3-phosphate dehydrogenase
FT active site"
FT CDS 231286..232524
FT /transl_table=11
FT /gene="pgk"
FT /locus_tag="Rv1437"
FT /product="PROBABLE PHOSPHOGLYCERATE KINASE PGK"
FT /function="INVOLVED IN THE SECOND PHASE OF GLYCOLYSIS
FT (SECOND STEP) [CATALYTIC ACTIVITY : ATP +
FT 3-PHOSPHO-D-GLYCERATE = ADP + 3-PHOSPHO-D-GLYCEROYL
FT PHOSPHATE]"
FT /EC_number="2.7.2.3"
FT /note="Rv1437, (MTCY493.17c), len: 412 aa. Probable pgk,
FT Phosphoglycerate kinase (EC 2.7.2.3), highly similar to
FT many e.g. PGK_MYCLE|P46712 Mycobacterium leprae (416 aa),
FT FASTA scores: opt: 2153, E(): 0, (80.4% identity in 414 aa
FT overlap). Contains PS00111 Phosphoglycerate kinase
FT signature. BELONGS TO THE PHOSPHOGLYCERATE KINASE FAMILY."
FT /db_xref="GOA:P65700"
FT /db_xref="InterPro:IPR001576"
FT /db_xref="InterPro:IPR015824"
FT /db_xref="InterPro:IPR015901"
FT /db_xref="InterPro:IPR015911"
FT /db_xref="UniProtKB/Swiss-Prot:P65700"
FT /protein_id="CAB09247.1"
FT /translation="MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASA
FT PTLKALLDADAKVVVAAHLGRPKDGPDPTLSLAPVAVALGEQLGRHVQLAGDVVGADAL
FT ARAEGLTGGDILLLENIRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVVHRK
FT QASVYDIATLLPHYAGTLVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATK
FT ADSIVIGGGMCFTFLAAQGFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFA
FT ADSPPQTVDVGAVPNGLMGLDIGPGSIKRFSTLLSNAGTIFWNGPMGVFEFPAYAAGTR
FT GVAEAIVAATGKGAFSVVGGGDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGI
FT EVLSREQPTGGVL"
FT misc_feature 232255..232278
FT /note="PS00111 Phosphoglycerate kinase signature"
FT CDS 232521..233306
FT /transl_table=11
FT /gene="tpi"
FT /locus_tag="Rv1438"
FT /product="PROBABLE TRIOSEPHOSPHATE ISOMERASE TPI (TIM)"
FT /function="PLAYS AN IMPORTANT ROLE IN SEVERAL METABOLIC
FT PATHWAYS [CATALYTIC ACTIVITY : D-GLYCERALDEHYDE 3-PHOSPHATE
FT = GLYCERONE PHOSPHATE]"
FT /EC_number="5.3.1.1"
FT /note="Rv1438, (MTCY493.16c), len: 261 aa. Probable tpi
FT (tpiA), Triosephosphate isomerase (EC 5.3.1.1), highly
FT similar to many e.g. TPIS_MYCLE|P46711 Mycobacterium leprae
FT (261 aa), FASTA scores: opt: 1456, E(): 0, (83.9% identity
FT in 261 aa overlap). Contains PS00171 Triosephosphate
FT isomerase active site. BELONGS TO THE TRIOSEPHOSPHATE
FT ISOMERASE FAMILY."
FT /db_xref="GOA:P66940"
FT /db_xref="InterPro:IPR000652"
FT /db_xref="InterPro:IPR013785"
FT /db_xref="InterPro:IPR020861"
FT /db_xref="PDB:3GVG"
FT /db_xref="UniProtKB/Swiss-Prot:P66940"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB09268.1"
FT /translation="MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIP
FT PFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERR
FT TYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQ
FT IGSVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAK
FT NVGDIVAQDDVDGGLVGGASLDGEHFATLAAIAAGGPLP"
FT misc_feature 233028..233060
FT /note="PS00171 Triosephosphate isomerase active site"
FT CDS complement(233918..234343)
FT /transl_table=11
FT /locus_tag="Rv1439c"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1439c, (MTCY493.15), len: 141 aa. Hypothetical
FT unknown protein."
FT /db_xref="UniProtKB/TrEMBL:O06820"
FT /protein_id="CAB09267.1"
FT /translation="MQMSASNAFVEGFADFWKAPSPDRLTDHLHPDVVLVRPLSPPRHG
FT LGAAQREFTRILGLLPDLHGEVDRWSQAGDVVFIEFRLIARLGSEVVEWPVVDRFLLRG
FT DKAVERVSYFDSLPLLIKVVKHPSAWRGWLTTMRSRA"
FT CDS 234794..235027
FT /transl_table=11
FT /gene="secG"
FT /locus_tag="Rv1440"
FT /product="PROBABLE PROTEIN-EXPORT MEMBRANE PROTEIN
FT (TRANSLOCASE SUBUNIT) SECG"
FT /function="INVOLVED IN PROTEIN EXPORT. PARTICIPATES IN A
FT EARLY EVENT OF PROTEIN TRANSLOCATION."
FT /note="Rv1440, (MTCY493.14c), len: 77 aa. Probable secG,
FT protein-export membrane protein (translocase subunit) (see
FT citation below), similar to many e.g. P38388|SECG_MYCLE
FT PROBABLE PROTEIN-EXPORT MEMBRANE (77 aa), FASTA scores:
FT opt: 450, E(): 6.7e-24, (96.1% identity in 77 aa overlap).
FT Start changed since original submission (-40 aa). PART OF
FT THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH
FT COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638,
FT SECF|Rv2586c, SECG AND SECY|Rv0732."
FT /db_xref="GOA:P66791"
FT /db_xref="InterPro:IPR004692"
FT /db_xref="UniProtKB/Swiss-Prot:P66791"
FT /protein_id="CAB09266.2"
FT /translation="MELALQITLIVTSVLVVLLVLLHRAKGGGLSTLFGGGVQSSLSGS
FT TVVEKNLDRLTLFVTGIWLVSIIGVALLIKYR"
FT CDS complement(235166..236641)
FT /transl_table=11
FT /gene="PE_PGRS26"
FT /locus_tag="Rv1441c"
FT /product="PE-PGRS FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1441c, (MTCY493.13), len: 491 aa. Member of the
FT Mycobacterium tuberculosis PE family, PGRS subfamily of
FT gly-rich proteins (see Brennan & Delogu 2002), similar to
FT Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa
FT protein (498 aa), fasta scores: opt: 1625, E(): 0, (55.2%
FT identity in 518 aa overlap)."
FT /db_xref="InterPro:IPR000084"
FT /db_xref="UniProtKB/TrEMBL:Q79FP3"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55389.1"
FT /translation="MSNVMVVPGMLSAAAADVASIGAALSAANGAAAPTTAGVLAAGAD
FT EVSAAIASLFSGYARDYQALSAQMARFHQQFVQALTASVGSYAAAEAANASPLQALEQQ
FT VLAAINAPTQTLLGRPLIGNGADGLPGQNGGAGGLLWGNGGNGGAGDAAHPNGGNGGDA
FT GMFGNGGAGGAGYSPAAGTGAAGGAGGAGGAGGWLSGNGGAGGNGGTGASGADGGGGLP
FT PVPASPGGNGGGGDAGGAAGMFGTGGAGGTGGDGGAGGAGDSPNSGANGARGGDGGNGA
FT AGGAGGRLFGNGGAGGNGGTAGQGGDGGTALGAGGIGGDGGTGGAGGTGGTAGIGGSSA
FT GAGGAGGDGGAGGTGGGSSMIGGKGGTGGNGGVGGTGGASALTIGNGSSAGAGGAGGAG
FT GTGGTGGYIESLDGKGQAGNGGNGGNGAAGGAGGGGTGAGGNGGAGGNGGDGGPSQGGG
FT NPGFGGDGGTGGPGGVGVPDGIGGANGAQGKHG"
FT CDS 236748..239048
FT /transl_table=11
FT /gene="bisC"
FT /locus_tag="Rv1442"
FT /product="PROBABLE BIOTIN SULFOXIDE REDUCTASE BISC (BDS
FT reductase) (BSO reductase)"
FT /function="THIS ENZYME MAY SERVE AS A SCAVENGER, ALLOWING
FT THE CELL TO UTILIZE BIOTIN SULFOXIDE AS A BIOTIN SOURCE"
FT /EC_number="1.-.-.-"
FT /note="Rv1442, (MTCY493.12c), len: 766 aa. Probable bisC,
FT Biotin sulfoxide reductase (EC 1.-.-.-), similar to
FT BISC_ECOLI|P20099 biotin sulfoxide reductase from
FT Escherichia coli (739 aa), FASTA scores: opt: 1271, E():0,
FT (40.2% identity in 744 aa overlap)."
FT /db_xref="GOA:O06817"
FT /db_xref="HSSP:1EU1"
FT /db_xref="InterPro:IPR006656"
FT /db_xref="InterPro:IPR006657"
FT /db_xref="InterPro:IPR006658"
FT /db_xref="InterPro:IPR009010"
FT /db_xref="UniProtKB/TrEMBL:O06817"
FT /protein_id="CAB09264.1"
FT /translation="MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAPQLQNLPGAV
FT RHRSRIANPAVRRGWLQHGPGPSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAI
FT YGSSYGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAALFEALA
FT ETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRYRARGGRLVSVSPLR
FT DDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERY
FT LLGLDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMA
FT ATLAAMLGQIGLPGGGFGHGYSSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQ
FT RPGQRLAYNGRLLELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMA
FT KHADIVVPTTTSFERDDFAASKTNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQ
FT FTEGRSAREWLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAH
FT PLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLHLIANQPRTRLH
FT SQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRVFNDRGACLAGVVIDDGLRP
FT KVVQLSTGAWFDPADPRDPDSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGE
FT LPPVRAHEPPRLA"
FT CDS complement(239164..239649)
FT /transl_table=11
FT /locus_tag="Rv1443c"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1443c, (MTCY493.11), len: 161 aa. Hypothetical
FT unknown protein."
FT /db_xref="InterPro:IPR019587"
FT /db_xref="UniProtKB/TrEMBL:O06816"
FT /protein_id="CAB09263.1"
FT /translation="MVGYAEPVLIERQSVVAAPAEQVWQRVVTPEGINDELRPWMTMSV
FT PRGAKGMTVDTVPIGAPIGRAWLRLFGVLPFDYDRLSIAELEPGRRFREDSTMLSMRQW
FT QHERTVTPEGDTKTIVRDRITFQTRAGLRFAAPLIAAGLRALFGHRHRRLQRHFAQG"
FT CDS complement(240244..240654)
FT /transl_table=11
FT /locus_tag="Rv1444c"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1444c, (MTCY493.10), len: 136 aa. Hypothetical
FT unknown protein."
FT /db_xref="UniProtKB/TrEMBL:O06815"
FT /protein_id="CAB09262.1"
FT /translation="MTVMADRSGRPAPVRRRMKTLTQAALNADKTVEQVEDVLDGLGKT
FT MAELNSSLSQLNSTVERLEDGLDHLEGTLHSLDDLAKRLIVLVEPVEAIVDRIDYIVSL
FT GETVMSPLSVTEHAVRGVLDRLRNRTVHEPTN"
FT CDS complement(240671..241414)
FT /transl_table=11
FT /gene="devB"
FT /locus_tag="Rv1445c"
FT /product="PROBABLE 6-PHOSPHOGLUCONOLACTONASE DEVB (6PGL)"
FT /function="INVOLVED IN PENTOSE PHOSPHATE PATHWAY.
FT HYDROLYSIS OF 6-PHOSPHOGLUCONOLACTONE TO 6-
FT PHOSPHOGLUCONATE. [CATALYTIC ACTIVITY :
FT 6-PHOSPHO-D-GLUCONO-1,5-LACTONE + H(2)O = 6-
FT PHOSPHO-D-GLUCONATE]"
FT /EC_number="3.1.1.31"
FT /note="Rv1445c, (MTCY493.09), len: 247 aa. Possible devB
FT (PGL), 6-phosphogluconolactonase (EC 3.1.1.31), belongs to
FT a different family to the upstream gene zwf2. Similar to
FT e.g. DEVB_ANASP|P46016 putative glucose-6-phosphate
FT 1-dehydrogenase (239 aa), FASTA scores: opt: 439, E():
FT 2.6e-20, (34.0% identity in 247 aa overlap). BELONGS TO THE
FT GLUCOSAMINE/GALACTOSAMINE-6-PHOSPHATE ISOMERASE FAMILY.
FT 6-PHOSPHOGLUCONOLACTONASE SUBFAMILY."
FT /db_xref="GOA:P63338"
FT /db_xref="InterPro:IPR005900"
FT /db_xref="InterPro:IPR006148"
FT /db_xref="PDB:3ICO"
FT /db_xref="UniProtKB/Swiss-Prot:P63338"
FT /protein_id="CAB09261.1"
FT /translation="MSSSIEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGN
FT GIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQVHP
FT MAASDGDFGGDLDAAALAYEQVLAASAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAV
FT LESTRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSV
FT PAAGAVGRQNTLWLLDRDAAAKLPS"
FT CDS complement(241411..242322)
FT /transl_table=11
FT /gene="opcA"
FT /locus_tag="Rv1446c"
FT /product="PUTATIVE OXPP CYCLE PROTEIN OPCA"
FT /function="MAY BE INVOLVED IN THE FUNCTIONAL ASSEMBLY OF
FT GLUCOSE 6-PHOSPHATE DEHYDROGENASE"
FT /note="Rv1446c, (MTCY493.08), len: 303 aa. Putative opcA,
FT OxPP cycle protein. Highly similar to S72774 B1496_F1_30
FT protein from Mycobacterium leprae (265 aa), FASTA scores:
FT opt: 1056, E(): 0, (70.3% identity in 239 aa overlap). Also
FT similar to OPCA_NOSS2|P48971 putative oxppcycle protein
FT opca from Nostoc punctiforme (465 aa), fasta scores: opt:
FT 177, E(): 7.3e-05, (23.4% identity in 321 aa overlap). AIDS
FT IN G6PD ACTIVITY."
FT /db_xref="InterPro:IPR004555"
FT /db_xref="InterPro:IPR019297"
FT /db_xref="UniProtKB/TrEMBL:O06813"
FT /protein_id="CAB09260.1"
FT /translation="MIVDLPDTTTTAVNKKLDELREKIGAVAMGRVLTLIIAPDSEAML
FT EESIEAANDASHEHPSRIIVTMRGDPYADRPRLDAQLRVGADAGAGEFVVLRLSGPLAG
FT HADSVVIPFLLPDIPVVAWWPDIAPAVPAQDALGKLAIRRITDATNAIDPLSAIKSRLA
FT GYGAGDTDLAWSRITYWRALLTSAVDQPRHEPIESALVSGLKTEPALDVLAGWLASRIE
FT GPVRRAVGELKVELVRNSETIVLSRPQEGITATLTRTGKPDALVPLARRVTGECLAEDL
FT RRLDPDEIYCAALEGIKKVQYR"
FT repeat_region complement(242323..242375)
FT /note="53 bp Mycobacterial Interspersed Repetitive Unit,
FT Class II"
FT CDS complement(242375..243919)
FT /transl_table=11
FT /gene="zwf2"
FT /locus_tag="Rv1447c"
FT /product="PROBABLE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE ZWF2
FT (G6PD)"
FT /function="INVOLVED IN PENTOSE PHOSPHATE PATHWAY [CATALYTIC
FT ACTIVITY : D-GLUCOSE 6-PHOSPHATE + NADP(+) = D-GLUCONO-
FT 1,5-LACTONE 6-PHOSPHATE + NADPH]"
FT /EC_number="1.1.1.49"
FT /note="Rv1447c, (MTCY493.07), len: 514 aa. Probable zwf2
FT (ZWF), Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49),
FT highly similar to many e.g. G6PD_SYNY3|P73411 Synechocystis
FT sp. (509 aa), FASTA scores: opt: 1578, E(): 0, (46.8%
FT identity in 509 aa overlap). Also similar to M.
FT tuberculosis Rv1121, zwf glucose-6-phosphate
FT 1-dehydrogenase. Contains PS00069 Glucose-6-phosphate
FT dehydrogenase active site. Mycobacterium tuberculosis has
FT two genes for ZWF. This one looks like a classical ZWF.
FT BELONGS TO THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE FAMILY."
FT /db_xref="GOA:P0A584"
FT /db_xref="InterPro:IPR001282"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="InterPro:IPR019796"
FT /db_xref="UniProtKB/Swiss-Prot:P0A584"
FT /protein_id="CAB09259.1"
FT /translation="MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKV
FT MPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEG
FT FRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLAR
FT PQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFA
FT NQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEP
FT VSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTT
FT ETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNA
FT MVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEP
FT SLFPVNAEVELAWEILDPALEHWAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP"
FT misc_feature complement(243287..243307)
FT /note="PS00069 Glucose-6-phosphate dehydrogenase active
FT site"
FT CDS complement(243916..245037)
FT /transl_table=11
FT /gene="tal"
FT /locus_tag="Rv1448c"
FT /product="PROBABLE TRANSALDOLASE TAL"
FT /function="TRANSALDOLASE IS IMPORTANT FOR THE BALANCE OF
FT METABOLITES IN THE PENTOSE-PHOSPHATE PATHWAY [CATALYTIC
FT ACTIVITY : SEDOHEPTULOSE 7-PHOSPHATE + D-GLYCERALDEHYDE
FT 3-PHOSPHATE = D-ERYTHROSE 4-PHOSPHATE + D-FRUCTOSE
FT 6-PHOSPHATE]"
FT /EC_number="2.2.1.2"
FT /note="Rv1448c, (MTCY493.06), len: 373 aa. Probable tal,
FT Transaldolase (EC 2.2.1.2), highly similar to many e.g.
FT TAL_MYCLE|P55193 transaldolase from Mycobacterium leprae
FT (375 aa), FASTA scores: opt: 1891, E(): 0, (78.6% identity
FT in 370 aa overlap). BELONGS TO THE TRANSALDOLASE FAMILY."
FT /db_xref="GOA:O06812"
FT /db_xref="InterPro:IPR001585"
FT /db_xref="InterPro:IPR004732"
FT /db_xref="InterPro:IPR013785"
FT /db_xref="InterPro:IPR014634"
FT /db_xref="InterPro:IPR018225"
FT /db_xref="UniProtKB/Swiss-Prot:O06812"
FT /protein_id="CAB09258.1"
FT /translation="MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVGV
FT TTNPSIFQKALSEGHTYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDSDG
FT VDGRVSIEVDPRLAHETEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAEGIS
FT VNVTLIFSVQRYREVMDAYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRLDRIG
FT SRQALELRGQAGVANARLAYATYREVFEDSDRYRSLKVDGARVQRPLWASTGVKNPDYS
FT DTLYVTELVAPHTVNTMPEKTIDAVADHGVIQGDTVTGTASDAQAVFDQLGAIGIDLTD
FT VFAVLEEEGVRKFEASWNELLQETRAHLDTAAQ"
FT CDS complement(245054..247156)
FT /transl_table=11
FT /gene="tkt"
FT /locus_tag="Rv1449c"
FT /product="PROBABLE TRANSKETOLASE TKT (TK)"
FT /function="This enzyme, together with transaldolase,
FT provides a link between the glycolytic and
FT pentose-phosphate pathways. It catalyzes the reversible
FT transfer of a two-carbon ketol unit from xylulose
FT 5-phosphate to an aldose receptor [CATALYTIC ACTIVITY:
FT Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate =
FT D-ribose 5-phosphate + D-xylulose 5-phosphate]"
FT /EC_number="2.2.1.1"
FT /note="Rv1449c, (MTCY493.05), len: 700 aa. Probable tkt,
FT Transketolase (EC 2.2.1.1). Highly similar to several e.g.
FT TKT_MYCLE|P46708 transketolase (tk) from Mycobacterium
FT leprae (699 aa), FASTA scores: opt: 4216, E(): 0, (89.1%
FT identity in 700 aa overlap). Start site chosen by homology.
FT Contains PS00801 Transketolase signature 1. BELONGS TO THE
FT TRANSKETOLASE FAMILY. Thought to be differentially
FT expressed within host cells (see Triccas et al., 1999)."
FT /db_xref="GOA:O06811"
FT /db_xref="InterPro:IPR005474"
FT /db_xref="InterPro:IPR005475"
FT /db_xref="InterPro:IPR005476"
FT /db_xref="InterPro:IPR005478"
FT /db_xref="InterPro:IPR009014"
FT /db_xref="InterPro:IPR015941"
FT /db_xref="InterPro:IPR020826"
FT /db_xref="UniProtKB/Swiss-Prot:O06811"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB09272.1"
FT /translation="MTTLEEISALTRPRHPDYWTEIDSAAVDTIRVLAADAVQKVGNGH
FT PGTAMSLAPLAYTLFQRTMRHDPSDTHWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELS
FT DIESLRTWGSKTPGHPEFRHTPGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPG
FT ASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDRNQISIEDDTNIALCED
FT TAARYRAYGWHVQEVEGGENVVGIEEAIANAQAVTDRPSFIALRTVIGYPAPNLMDTGK
FT AHGAALGDDEVAAVKKIVGFDPDKTFQVREDVLTHTRGLVARGKQAHERWQLEFDAWAR
FT REPERKALLDRLLAQKLPDGWDADLPHWEPGSKALATRAASGAVLSALGPKLPELWGGS
FT ADLAGSNNTTIKGADSFGPPSISTKEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTR
FT AYGGTFLQFSDYMRPAVRLAALMDIDTIYVWTHDSIGLGEDGPTHQPIEHLSALRAIPR
FT LSVVRPADANETAYAWRTILARRNGSGPVGLILTRQGVPVLDGTDAEGVARGGYVLSDA
FT GGLQPGEEPDVILIATGSEVQLAVAAQTLLADNDILARVVSMPCLEWFEAQPYEYRDAV
FT LPPTVSARVAVEAGVAQCWHQLVGDTGEIVSIEHYGESADHKTLFREYGFTAEAVAAAA
FT ERALDN"
FT misc_feature complement(247004..247066)
FT /note="PS00801 Transketolase signature 1"
FT CDS complement(247595..251584)
FT /transl_table=11
FT /gene="PE_PGRS27"
FT /locus_tag="Rv1450c"
FT /product="PE-PGRS FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1450c, (MTCY493.04), len: 1329 aa. Member of the
FT Mycobacterium tuberculosis PE family, PGRS subfamily of
FT gly-rich proteins (see citation below), similar to
FT Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa
FT protein (603 aa), fasta scores: opt: 2112, E(): 0, (56.5%
FT identity in 630 aa overlap)."
FT /db_xref="InterPro:IPR000084"
FT /db_xref="UniProtKB/TrEMBL:Q79FP2"
FT /protein_id="CAE55390.1"
FT /translation="MSLVIVAPETVAAAALDVARIGSSIGAANAAAAGSTTSVLAAGAD
FT EVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLEHN
FT VLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGILWGNGGAGGSGAPGQVGGAGGA
FT AGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGV
FT GGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGGAAGLL
FT GVGGHGGAGGHGAEGVAGAAGEDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAGGAGGAG
FT GVGGTGGAGGAGFSRALIVAGDNGGDPGAGGAGGTGGAGSTIGAHGAAGASPTSGGNGG
FT AGGNGAHFSSGGKAGGNGGAGGAGGLVGNGGAGGAGGNGAPGAPPSGGDPNGGGGGAGG
FT AGGKGGDGGAQAGDGGAGGAGGKGGNGGNGATGATGLNGLGAGADGTDGGKGGNGGAGG
FT GGGAGGQGGKALAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDNGGDGVGGNGG
FT NGGSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGANATVAGGAGGAGGKGG
FT NGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGAGGAGGAGGRGGDFGGDGG
FT TGGAGGNGANGANATTPGAKGGDGGHGGPGAQGGNGGQGGPGGLAGNLFGQNGIQGVGG
FT SGGKGGAGGLAGDGGNGANGNFAFGDGNGGHGGNGGNPGAGGQGGSGGAGSTPGAKGAH
FT GFTPTSGGDGGDGGNGGNSQVVGGNGGDGGNGGNGGSAGTGGNGGRGGDGAFGGMSANA
FT TNPGENGPNGNPGGNGGAGGAGGAGLNGGNGGAGGNGGLGGFGGNGAAGANGVAVGAPG
FT QPGGAGGHGGAGGNGGAGGNGGQGVVSDGAGGAGGAGGDGGAPGDGANGGNGQGAGAFA
FT GGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGGHGAASGGNGGP
FT GGHGGNGGNGGTGANGGNGGIGGTGGAGSTGAKGVLGTNEGDGGDGGRGGNGGRGGNGG
FT QGLTGAGGNGGTGGTPGNGGNGGNGASGDLVTSPGDGGGGGRGGDAGRGGDAGLGGSSG
FT PGGTPGDWGTGGTGGTGGTGGQGANGGLTGGRGGTGGNGGNGNTGGTGGAGGTGGTGHN
FT GSQPGMGGNGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAGPFGTGTGGTGGHGGQGG
FT GGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGFGGLGGGEFV"
FT repeat_region complement(250488..251747)
FT /note="1260 bp imperfect direct repeat 2, first copy at
FT 1637133..1638392"
FT CDS 251986..252912
FT /transl_table=11
FT /gene="ctaB"
FT /locus_tag="Rv1451"
FT /product="PROBABLE CYTOCHROME C OXIDASE ASSEMBLY FACTOR
FT CTAB"
FT /function="THOUGHT TO BE INVOLVED IN AEROBIC RESPIRATION."
FT /note="Rv1451, (MTCY493.03c), len: 308 aa. Probable ctaB,
FT cytochrome C oxidase assembly factor, and integral membrane
FT protein. Highly similar to several Mycobacterium leprae
FT proteins e.g. Q49685 CYOE cytochrome O ubiquinol oxidase
FT assembly factor (300 aa), FASTA scores: opt: 1636, E(): 0,
FT (82.7% identity in 307 aa overlap); NP_301495.1|NC_002677
FT putative protoheme IX farnesyltransferase (321 aa);
FT NP_301495.1|NC_002677 putative protoheme IX
FT farnesyltransferase (321 aa)."
FT /db_xref="GOA:O06809"
FT /db_xref="InterPro:IPR000537"
FT /db_xref="InterPro:IPR006369"
FT /db_xref="UniProtKB/Swiss-Prot:O06809"
FT /protein_id="CAB09270.1"
FT /translation="MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLL
FT ADRGAIHPLLMLNTLVGGMMAAAGANTLNCVADADIDKVMKRTARRPLAREAVPTRNAL
FT ALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMP
FT VMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQV
FT TKQILIYTWLTVAATLVLALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRL
FT FLQSNNYLAVVFCALAVDSVIALPTLH"
FT CDS complement(252961..255186)
FT /transl_table=11
FT /gene="PE_PGRS28"
FT /locus_tag="Rv1452c"
FT /product="PE-PGRS FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1452c, (MTCY493.02), len: 741 aa. Member of the
FT Mycobacterium tuberculosis PE family, PGRS subfamily of
FT gly-rich proteins (see citation below), similar to
FT Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa
FT protein (603 aa), fasta scores: opt: 2090, E(): 0, (56.3%
FT identity in 641 aa overlap)."
FT /db_xref="InterPro:IPR000084"
FT /db_xref="UniProtKB/TrEMBL:Q79FP1"
FT /protein_id="CAE55391.1"
FT /translation="MSLVIVTPETVAAAASDVARIGSSIGVANSAAAGSTTSVLAAGAD
FT EVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLEHN
FT VLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGILWGNGGAGGSGAPGQVGGAGGA
FT AGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGV
FT GGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGGAAGLL
FT GVGGHGGAGGHGAEGVAGAAGEDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAGGAGGAG
FT GVGGTGGAGGAGFSRALIVAGDNGGDGGNGGMGGAGGAGGPGGAGGLISLLGGQGAGGA
FT GGTGGAGGVGGDRGAGGPGNQAFNAGAGGAGGHGGDPGAGGAGGTGGAGSITGAQGAIG
FT ATPTSGGNGGAGGNGANATTAGTNGANGGPGGHGGLVGNGGAGGNGANGAAGTNASDSG
FT AVGGKGNSGGNGGQGGAGGDGGTLAGNGGAGGTGGRGADGGLGGSGAEGANATTAGERG
FT QDGGKGGNGGVGGTGGNAVAPGANGGHGGNGGNPGFSGAGGLGGLSGDGVTRAAQGATP
FT DFADTGGKGGNGGNGANAVAPGGTGASGGAGGNAGAGGKGGENIIGDGGGGNGGAGGKG
FT GAGTLLGLTVFGDNGGAGVLGDSTDPDGSGGAGGAGGAGGAGGDPTI"
FT repeat_region complement(254090..255349)
FT /note="1260 bp imperfect direct repeat 1, second copy at
FT 1633531..1634790"
FT CDS 255338..256603
FT /transl_table=11
FT /locus_tag="Rv1453"
FT /product="POSSIBLE TRANSCRIPTIONAL ACTIVATOR PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1453, (MTCY493.01c), len: 421 aa. Possible
FT transcriptional activator, similar to Q50018 putative
FT transcriptional activator trx from Mycobacterium leprae
FT (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity
FT in 500 aa overlap). Also highly similar to Mycobacterium
FT tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,
FT and to the further upstream ORF's Rv1429|MTCY493.25c (28.1%
FT identity in 335 aa overlap). Start changed since first
FT submission (-11 aa)."
FT /db_xref="UniProtKB/TrEMBL:O06807"
FT /protein_id="CAB09273.2"
FT /translation="MALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIAA
FT DPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALDIY
FT RIGQNVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEFVDTTLAGITTEMQLERDKLT
FT RDVPAERRKIVQLLIDGAPISREHAEARLGYPLDRSHTAAVIWGDQAQGDHSHLDRVAD
FT AFGHAGGCPHPLVVVAGAATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATAPGIEG
FT FRRSHRDALTTARMIIRLESPHRVAFFTDVEMVALLTENAEGADDFIQRTLGNLESASP
FT ALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALEAQ
FT QWREKPTSDPPAKKESNGTKMR"
FT CDS complement(256631..257617)
FT /transl_table=11
FT /gene="qor"
FT /locus_tag="Rv1454c"
FT /product="PROBABLE QUINONE REDUCTASE QOR (NADPH:quinone
FT reductase) (Zeta-crystallin homolog protein)"
FT /function="Catalyzes the one electron reduction of certain
FT quinones [CATALYTIC ACTIVITY: NADPH + quinone = NADP+ +
FT semiquinone]"
FT /EC_number="1.6.5.5"
FT /note="Rv1454c, (MTV007.01c), len: 328 aa. Probable qor,
FT quinone oxidoreductase (EC 1.6.5.5), simiar to
FT U87282|RCU87282_2 quinone oxidoreductase from Rhodobacter
FT capsulatus (323 aa), FASTA scores: opt: 849, E(): 0, (44.7%
FT identity in 329 aa overlap). Also similar to MTCY180.06
FT Hypothetical protein from Mycobacterium tuberculosis (334
FT aa), FASTA scores: opt: 430, E(): 2e-14, (32.3% identity in
FT 350 aa overlap). TBparse score is 0.887. Contains PS01162
FT Quinone oxidoreductase / zeta-crystallin signature."
FT /db_xref="GOA:O53146"
FT /db_xref="HSSP:1QOR"
FT /db_xref="InterPro:IPR002085"
FT /db_xref="InterPro:IPR011032"
FT /db_xref="InterPro:IPR013149"
FT /db_xref="InterPro:IPR013154"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="UniProtKB/TrEMBL:O53146"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA15984.1"
FT /translation="MHAIEVTETGGPGVLRHVDQPQPQPGHGELLIKAEAIGVNFIDTY
FT FRSGQYPRELPFVIGSEVCGTVEAVGPGVTAADTAISVGDRVVSASANGAYAEFCTAPA
FT SLTAKVPDDVTSEVAASALLKGLTAHYLLKSVYPVKRGDTVLVHAGAGGVGLILTQWAT
FT HLGVRVITTVSTAEKAKLSKDAGADVVLDYPEDAWQFAGRVRELTGGTGVQAVYDGVGA
FT TTFDASLASLAVRGTLALFGAASGPVPPVDPQRLNAAGSVYLTRPSLFHFTRTGEEFSW
FT RAAELFDAIGSEAITVAVGGRYPLADALRAHQDLEARKTVGSVVLLP"
FT misc_feature complement(257138..257191)
FT /note="PS01162 Quinone oxidoreductase / zeta-crystallin
FT signature"
FT CDS 257637..258500
FT /transl_table=11
FT /locus_tag="Rv1455"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1455, (MTV007.02), len: 287 aa. Conserved
FT hypothetical protein, some similarity from aa 80-160 to
FT Z99125|MLCL536.35c hypothetical Mycobacterium leprae
FT protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08,
FT (51.3% identity in 78 aa overlap). TBparse score is 0.915."
FT /db_xref="UniProtKB/TrEMBL:O53147"
FT /protein_id="CAA15985.1"
FT /translation="MKLARPDVFHPRVVLAGWPQQPAGDGDDAGLVAALRHRGLHAGWL
FT SWDDPEIVHADLVILRATRDYPARLDEFLAWTTRVANLLNSRPVVAWNVERRYLRDLMD
FT RGVPTVPGEVYVPGEPVRLPRKGQVFVGPTIGTGTRRCSARFAAEFVAQLHAAGQAVLV
FT QPGGSGDETVLVFLGGEPSHAFTKQADTWRQTEPDFEIWDVGAAAVAGAAAQVGVDPGE
FT LLYARAHITGGSRDPRLLELQLVDPSLGWQWLDPDIRNLAQRDFALCVQSALERLGLGP
FT FSHRRP"
FT CDS complement(258450..259382)
FT /transl_table=11
FT /locus_tag="Rv1456c"
FT /product="PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT
FT INTEGRAL MEMBRANE ABC TRANSPORTER"
FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT ANTIBIOTIC ACROSS THE MEMBRANE (EXPORT): UNIDENTIFIED
FT ANTIBIOTIC RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE
FT FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE
FT MEMBRANE."
FT /note="Rv1456c, (MTV007.03c), len: 310 aa. Possible
FT unidentified antibiotic-transport integral membrane protein
FT ABC transporter (see citation below), equivalent to
FT Z99125|MLCL536.34 from Mycobacterium leprae (311 aa), FASTA
FT scores: opt: 1607, E(): 0, (83.3% identity in 300 aa
FT overlap). TBparse score is 0.886."
FT /db_xref="GOA:O53148"
FT /db_xref="InterPro:IPR003780"
FT /db_xref="UniProtKB/TrEMBL:O53148"
FT /protein_id="CAA15986.1"
FT /translation="MPYDRAVSPSLRVQRVIAAIVILTQGGIAVTGAIVRVTASGLGCP
FT TWPQCFPGSFTPVVVAEVPRVHQAVEFGNRMVTFAVVIAAALAVLVVTRARRRTEVLAY
FT AWLMPVSTVVQAMIGGITVRTGLLWWTVAIHLLASMTMVWLAVLLYVKIGQPDDGVVHE
FT LVVSPLRALTALSALNLAAVLVTGTLVTAAGPHAGDRSPSRTVPRLKVEITTLVHMHSS
FT LLVAYLALLIGLGFGLLAVGATRAILVRLAVLLALVATQAAVGTTQYFTGVPAALVAIH
FT VAGAAAVTAATAALWASMGERAQPQPLQR"
FT CDS complement(259494..260279)
FT /transl_table=11
FT /locus_tag="Rv1457c"
FT /product="PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT
FT INTEGRAL MEMBRANE ABC TRANSPORTER"
FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT ANTIBIOTIC ACROSS THE MEMBRANE (EXPORT): UNIDENTIFIED
FT ANTIBIOTIC RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE
FT FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE
FT MEMBRANE."
FT /note="Rv1457c, (MTV007.04c), len: 261 aa. Possible
FT unidentified antibiotic-transport integral membrane protein
FT ABC transporter (see citation below), equivalent to
FT Z99125|MLCL536.32 from Mycobacterium leprae (265 aa), FASTA
FT scores: opt: 1415, E(): 0, (83.1% identity in 260 aa
FT overlap). TBparse score is 0.877."
FT /db_xref="GOA:O86349"
FT /db_xref="InterPro:IPR004377"
FT /db_xref="InterPro:IPR013525"
FT /db_xref="UniProtKB/TrEMBL:O86349"
FT /protein_id="CAA15987.1"
FT /translation="MTQTNRPAFPAGTFSPDPRPNAVPLMLAAQFSLELKLLLRNGEQL
FT LLTMFIPITLLVGLTLLPMGSFGHNRAATFVPVIMALAVISTAFTGQAIAVAFDRRYGA
FT LKRLGATPLPVWGIIAGKSLAVVAVVFLQAIILGAIGFALGWRPALTALTLGAGIIALG
FT TAGFAALGLLLGGTLRAEIVLAVANLMWFVFAGFGALTLESNVIPTAFKWVARVTPSGA
FT LTEALSQAMTVSVDWFGIVVLAVWGALAALAALRWFRFT"
FT CDS complement(260276..261217)
FT /transl_table=11
FT /locus_tag="Rv1458c"
FT /product="PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT
FT ATP-BINDING PROTEIN ABC TRANSPORTER"
FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT ANTIBIOTIC ACROSS THE MEMBRANE (EXPORT): UNIDENTIFIED
FT ANTIBIOTIC RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE
FT FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM."
FT /note="Rv1458c, (MTV007.05c), len: 313 aa. Possible
FT unidentified antibiotic-transport ATP-binding protein ABC
FT transporter (see citation below), equivalent to
FT Z99125|MLCL536.31 from Mycobacterium leprae (315 aa), FASTA
FT scores: opt: 1812, E(): 0, (88.0% identity in 308 aa
FT overlap). Similar to AF027770|AF027770_7 ABC-type
FT transporter in FxbA region in Mycobacterium smegmatis (284
FT aa), FASTA scores: opt: 1412, E(): 0, (85.1% identity in
FT 248 aa overlap). Contains PS00017 ATP/GTP-binding site
FT motif A (P-loop) and PS00211 ABC transporters family
FT signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN
FT FAMILY (ABC TRANSPORTERS). TBparse score is 0.874."
FT /db_xref="GOA:O53149"
FT /db_xref="HSSP:1JI0"
FT /db_xref="InterPro:IPR003439"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR017871"
FT /db_xref="UniProtKB/TrEMBL:O53149"
FT /protein_id="CAA15988.1"
FT /translation="MNRAPDTPEVVLRLRGVCKRYGSITAVSNLDLDVHDAEVMALLGP
FT NGAGKTTTVEMCEGFVRPDAGSIEVLGLDPITDNARLRARIGVMLQGGGGYPAARAGEM
FT LDLVASYAANPLDPHWLLDTLGLTEAARTTYRRLSGGQQQRLALACALVGRPQLVFLDE
FT PTAGMDAHARVLVWELIDALRRDGVTVVLTTHHLKEAEELADRLVIIDHGVTVAAGTPA
FT ELMRSGAKDQLRFTAPPRLDLSLLASALPEGYQATELTPGEYLVEGPVDPQVLATVTAW
FT CAQIDVLATDMRVEQRSLEDVFLDLTGRKLRQ"
FT misc_feature complement(260762..260806)
FT /note="PS00211 ABC transporters family signature"
FT misc_feature complement(261065..261088)
FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT repeat_region complement(261218..261270)
FT /note="53 bp Mycobacterial Interspersed Repetitive Unit,
FT Class II"
FT repeat_region complement(261271..261321)
FT /note="51 bp Mycobacterial Interspersed Repetitive Unit,
FT Class II"
FT CDS complement(261320..263095)
FT /transl_table=11
FT /locus_tag="Rv1459c"
FT /product="POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1459c, (MTV007.06c), len: 591 aa. Possible
FT conserved integral membrane protein, equivalent to
FT MLCL536.30|Z99125 hypothetical protein from Mycobacterium
FT leprae (593 aa), FASTA scores: opt: 1670, E(): 0, (78.6%
FT identity in 585 aa overlap). Also similar to M.
FT tuberculosis protein Rv2174|MTV021.07 (33.1% identity in
FT 523 aa overlap)."
FT /db_xref="UniProtKB/TrEMBL:O53150"
FT /protein_id="CAA15989.1"
FT /translation="MAARHHTLSWSIASLHGDEQAVGAPLTTTELTALARTRLFGATGT
FT VLMAIGALGAGARPVVQDPTFGVRLLNLPSRIQTVSLTMTTTGAVMMALAWLMLGRFTL
FT GRRRMSRGKLDRTLLLWMLPLLIAPPMYSKDVYSYLAQSEIGRDGLDPYRVGPASGLGL
FT GHVFTLSVPSLWRETPAPYGPLFLWIGRGISSLTGENIVAAVLCHRLVVLIGVTLIVWA
FT TPRLAQRCGVAEVSALWLGAANPLLIMHLVAGIHNEALMLGLMLTGVEFALRGLDMANT
FT PRPSPETWRLGPATIRASRRPELGASPRAGASRAVKPRPEWGPLAMLLAGSILITLSSQ
FT VKLPSLLAMGFVTTVLAYRWGGNLRALLLAAAVMASLTLAIMAILGWASGLGFGWINTL
FT GTANVVRSWMSPPTLLALGTGHVGILLGLGDHTTAVLSLTRAIGVLIITVMVCWLLLAV
FT LRGRLHPIGGLGVALAVTVLLFPVVQPWYLLWAIIPLAAWATRPGFRVAAILATLIVGI
FT FGPTANGDRFALFQIVDATAASAIIVILLIALTYTRLPWRPLAAEQVVTAAESASKTPA
FT TRRPTAAPDAYADST"
FT CDS 263143..263949
FT /transl_table=11
FT /locus_tag="Rv1460"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1460, (MTV007.07), len: 268 aa. Probable
FT transcriptional regulatory protein. Equivalent to
FT Z99125|MLCL536.29c hypothetical protein from Mycobacterium
FT leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6%
FT identity in 250 aa overlap). Possible helix-turn-helix
FT motif between aa 68 - 89. Start changed since original
FT submission. TBparse score is 0.904."
FT /db_xref="InterPro:IPR013196"
FT /db_xref="UniProtKB/TrEMBL:O53151"
FT /protein_id="CAA15990.2"
FT /translation="MTSTTLPHRASLVDRSTEFCHTDVVKIPAVSTTVPAAVSDGHTRR
FT AIVRLLLESGSITAGEIGDRLGLSAAGVRRHLDALIEAGDAEASAAAPWQQVGRGRPAK
FT RYRLTAAGRAKLDHSYDDLASAAMRQLREIGGEEAVRTFARRRIDAILADVAPADGPDD
FT AALEAAAERIATALSKAGYVATTTRVGGPIHGVQICQHHCPVSHVAEEFPELCETEQQA
FT MAEVLGTHVQRLATIVNGDCACTTHVPLSPAPSPRPPATSTEGASR"
FT CDS 263946..266486
FT /transl_table=11
FT /locus_tag="Rv1461"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1461, (MTV007.08), len: 846 aa. Conserved
FT hypothetical protein. Equivalent of spliced protein from
FT Mycobacterium leprae MLCL536.28c len: 869. Residues 1-253
FT represent N-extein, and 613-846 the C-extein. The intein
FT present from residues 254 - 612 is different in sequence
FT and site of the insertion from the one present in
FT MLCL536.28c. FASTA scores: Z99125|MLCL536_23 Mycobacterium
FT leprae cosmid L536 (869 aa), opt: 1498 E(): 0, (54.1%
FT identity in 917 aa overlap). The mature protein is similar
FT to Z99120|BSUB0017_150 hypothetical Bacillus subtilis
FT protein (465 aa), FASTA scores: opt:1053, E(): 0, (34.8%
FT identity in 821 aa overlap). The intein shows some
FT similarity to inteins from U67548|MJU67548_6 Methanococcus
FT jannaschii (895 aa), FASTA scores: opt: 181, E(): 0.00023,
FT (25.2% identity in 274 aa overlap). TBparse score is
FT 0.913."
FT /db_xref="GOA:P67125"
FT /db_xref="InterPro:IPR000825"
FT /db_xref="InterPro:IPR003586"
FT /db_xref="InterPro:IPR003587"
FT /db_xref="InterPro:IPR004042"
FT /db_xref="InterPro:IPR006141"
FT /db_xref="InterPro:IPR006142"
FT /db_xref="InterPro:IPR010231"
FT /db_xref="UniProtKB/Swiss-Prot:P67125"
FT /protein_id="CAA15991.1"
FT /translation="MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGAN
FT AQRGLSEAVVRDISAKKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVR
FT STEKQAASWDDLPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGV
FT IFLDTDTGLREHPDIFKEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQA
FT YFRINTENMGQFERTLIIADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTG
FT HDGRPHRVTAVQVRDLDGELFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWK
FT AEVNSTKLRSAEPRWIAAKDVAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHAC
FT LTNGCESLIFSFHSDEFEYVEDVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAM
FT RDNVGIGSSNKKLSDLLMRQDETFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAF
FT QLQSILARLGHYATVELRRPGGPGVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFA
FT VPIKKRAVREAHEPVYNLDVENPDSYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHA
FT RVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEV
FT LSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSS
FT VKCDALLVDTVSRSDTYPYVDIREDDVTMGHEATVSKVSENQLFYLMSRGLTEDEAMAM
FT VVRGFVEPIAKELPMEYALELNRLIELQMEGAVG"
FT CDS 266483..267676
FT /transl_table=11
FT /locus_tag="Rv1462"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1462, (MTV007.09), len: 397 aa. Conserved
FT hypothetical protein. Equivalent to MLCL536.27c|Z99125
FT hypothetical protein from Mycobacterium leprae (392 aa),
FT FASTA scores: opt: 2059, E(): 0, (80.4% identity in 392 aa
FT overlap). Also similar to nearby Mycobacterium tuberculosis
FT hypothetical protein Rv1461. TBparse score is 0.873."
FT /db_xref="GOA:O53153"
FT /db_xref="InterPro:IPR000825"
FT /db_xref="InterPro:IPR011542"
FT /db_xref="UniProtKB/Swiss-Prot:O53153"
FT /protein_id="CAA15992.1"
FT /translation="MTAPGLTAAVEGIAHNKGELFASFDVDAFEVPHGRDEIWRFTPLR
FT RLRGLHDGSARATGSATITVSERPGVYTQTVRRGDPRLGEGGVPTDRVAAQAFSSFNSA
FT TLVTVERDTQVVEPVGITVTGPGEGAVAYGHLQVRIEELGEAVVVIDHRGGGTYADNVE
FT FVVDDAARLTAVWIADWADNTVHLSAHHARIGKDAVLRHVTVMLGGDVVRMSAGVRFCG
FT AGGDAELLGLYFADDGQHLESRLLVDHAHPDCKSNVLYKGALQGDPASSLPDAHTVWVG
FT DVLIRAQATGTDTFEVNRNLVLTDGARADSVPNLEIETGEIVGAGHASATGRFDDEQLF
FT YLRSRGIPEAQARRLVVRGFFGEIIAKIAVPEVRERLTAAIEHELEITESTEKTTVS"
FT CDS 267673..268473
FT /transl_table=11
FT /locus_tag="Rv1463"
FT /product="PROBABLE CONSERVED ATP-BINDING PROTEIN ABC
FT TRANSPORTER"
FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT
FT ACROSS THE MEMBRANE. RESPONSIBLE FOR ENERGY COUPLING TO THE
FT TRANSPORT SYSTEM."
FT /note="Rv1463, (MTV007.10), len: 266 aa. Probable conserved
FT ATP-binding protein ABC transporter, equivalent to
FT Z99125|MLCL536.26c putative ABC transporter ATP-binding
FT protein from Mycobacterium leprae (260 aa), FASTA scores:
FT opt: 1444, E(): 0, (86.0% identity in 267 aa overlap). Very
FT similar to U38804|PPU38804_55 ATP-DEPENDENT TRANSPORTER
FT YCF16 from PORPHYRA PURPUREA chloroplast (251 aa), FASTA
FT scores: opt: 822, E(): 0, (52.4% identity in 248 aa
FT overlap); and similar to others. Contains PS00017
FT ATP/GTP-binding site motif A (P-loop). BELONGS TO THE
FT ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).
FT TBparse score is 0.872."
FT /db_xref="GOA:O53154"
FT /db_xref="InterPro:IPR003439"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR010230"
FT /db_xref="UniProtKB/TrEMBL:O53154"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA15993.1"
FT /translation="MTILEIKDLHVSVENPAEADHEIPILRGVDLTVKSGETHALMGPN
FT GSGKSTLSYAIAGHPKYHVTSGTITLDGADVLAMSIDERARAGLFLAMQYPVEVPGVSM
FT SNFLRSAATAIRGEPPKLRHWVKEVKAAMAALDIDPAFAERSVNEGFSGGEKKRHEILQ
FT LELLKPKIAILDETDSGLDVDALRVVSEGVNRYAESQHGGILLITHYTRILRYIHPEYV
FT HVFVGGRIVESGGSELADELDQNGYVRFSPASGRYPHQPAPTGA"
FT misc_feature 267799..267822
FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT CDS 268475..269728
FT /transl_table=11
FT /gene="csd"
FT /locus_tag="Rv1464"
FT /product="PROBABLE CYSTEINE DESULFURASE CSD"
FT /function="CATALYZES THE REMOVAL OF ELEMENTAL SULFUR AND
FT SELENIUM ATOMS FROM L-CYSTEINE, L-CYSTINE,
FT L-SELENOCYSTEINE, AND L-SELENOCYSTINE TO PRODUCE L-ALANINE"
FT /EC_number="4.4.1.-"
FT /note="Rv1464, (MTV007.11), len: 417 aa. Probable csd,
FT cysteine desulfurase (EC 4.4.1.- ). Equivalent to
FT Q49690|MLCL536.25C cysteine desulfurase from Mycobacterium
FT leprae (418 aa), FASTA scores: opt: 2333, E(): 0, (85.4%
FT identity in 417 aa overlap); and similar to cysteine
FT desulfurase from other organisms. Also similar to M.
FT tuberculosis proteins Rv3025c|ISCS and Rv3778c. Contains
FT PS00595 Aminotransferases class-V pyridoxal-phosphate
FT attachment site. TBparse score is 0.881. BELONGS TO CLASS-V
FT OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. CSD
FT SUBFAMILY."
FT /db_xref="GOA:P63516"
FT /db_xref="InterPro:IPR000192"
FT /db_xref="InterPro:IPR010970"
FT /db_xref="InterPro:IPR015421"
FT /db_xref="InterPro:IPR015424"
FT /db_xref="InterPro:IPR020578"
FT /db_xref="UniProtKB/Swiss-Prot:P63516"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA15994.1"
FT /translation="MTASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQV
FT LDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTKNATEALN
FT LVSYVLGDSRFERAVGPGDVIVTTELEHHANLIPWQELARRTGATLRWYGVTDDGRIDL
FT DSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHEL
FT GVDFAAFSGHKMLGPNGIGVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFE
FT AGTPMTSQVVGLAAAARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDR
FT GSPVAFVVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNTADE
FT VDRLVAGVRRSRHFFGRA"
FT misc_feature 269150..269203
FT /note="PS00595 Aminotransferases class-V
FT pyridoxal-phosphate attachment site"
FT CDS 269725..270213
FT /transl_table=11
FT /locus_tag="Rv1465"
FT /product="POSSIBLE NITROGEN FIXATION RELATED PROTEIN"
FT /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR
FT METABOLISM."
FT /note="Rv1465, (MTV007.12), len: 162 aa. Possible nitrogen
FT fixation related protein. Equivalent to Z99125|MLCL536.24c
FT nitrogen fixation protein NIFU from Mycobacterium leprae
FT (165 aa), FASTA scores: opt: 870, E(): 0, (81.8% identity
FT in 165 aa overlap). Also similar to
FT O32163|Z99120|NIFU_BACSU NifU-like protein from Bacillus
FT subtilis (147 aa), FASTA scores: opt: 354, E(): 4.1e-17,
FT (38.3% identity in 141 aa overlap) and to AL096839|SCC22.02
FT hypothetical protein from Streptomyces coelicolor (156 aa),
FT FASTA scores: opt: 569, E(): 1.2e-31, (56.3% identity in
FT 158 aa overlap). TBparse score is 0.898."
FT /db_xref="GOA:O53156"
FT /db_xref="InterPro:IPR002871"
FT /db_xref="InterPro:IPR011341"
FT /db_xref="UniProtKB/TrEMBL:O53156"
FT /protein_id="CAA15995.1"
FT /translation="MTLRLEQIYQDVILDHYKHPQHRGLREPFGAQVYHVNPICGDEVT
FT LRVALSEDGTRVTDVSYDGQGCSISQAATSVLTEQVIGQRVPRALNIVDAFTEMVSSRG
FT TVPGDEDVLGDGVAFAGVAKYPARVKCALLGWMAFKDALAQASEAFEEVTDERNQRTG"
FT CDS 270188..270535
FT /transl_table=11
FT /locus_tag="Rv1466"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1466, (MTV007.13), len: 115 aa. Conserved
FT hypothetical protein. Equivalent to Z99125|MLCL536.23c
FT hypothetical protein from Mycobacterium leprae (115 aa),
FT FASTA scores: opt: 648, E(): 0, (81.7% identity in 115 aa
FT overlap). Similar to ORF's downstream of sigma factors in
FT Streptococcus mutans and Streptococcus pneumoniae e.g.
FT O06451 ORF3 downstream of RpoD (SPDNAGCPO) (109 aa).
FT Alternative TTG start possible at 13757 then avoids overlap
FT with MTV007.12. TBparse score is 0.837."
FT /db_xref="InterPro:IPR002744"
FT /db_xref="UniProtKB/TrEMBL:O53157"
FT /protein_id="CAA16008.1"
FT /translation="MSETSAPAEELLADVEEAMRDVVDPELGINVVDLGLVYGLDVQDG
FT DEGTVALIDMTLTSAACPLTDVIEDQSRSALVGSGLVDDIRINWVWNPPWGPDKITEDG
FT REQLRALGFTV"
FT CDS complement(270630..272459)
FT /transl_table=11
FT /gene="fadE15"
FT /locus_tag="Rv1467c"
FT /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE15"
FT /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION."
FT /EC_number="1.3.99.-"
FT /note="Rv1467c, (MTV007.14c), len: 609 aa. Probable fadE15,
FT acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to
FT NP_302639.1|NC_002677 acyl-CoA dehydrogenase from
FT Mycobacterium leprae (611 aa). Also highly similar to many
FT e.g. T36481 probable acyl-CoA dehydrogenase (fragment) from
FT Streptomyces coelicolor (491 aa) (has its N-terminus very
FT shorter); NP_384640.1|NC_003047 PUTATIVE ACYL-CoA
FT DEHYDROGENASE PROTEIN from Sinorhizobium meliloti (598 aa);
FT ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain
FT specific) from Megasphaera elsdenii (383 aa), FASTA scores:
FT E(): 2e-12, (25.4% identity in 410 aa overlap); etc. Also
FT highly similar to fadE5|Rv0244c|MTV034.10c ACYL-CoA
FT DEHYDROGENASE from Mycobacterium tuberculosis (611 aa); and
FT similar to other proteins from Mycobacterium tuberculosis.
FT TBparse score is 0.892."
FT /db_xref="GOA:O53158"
FT /db_xref="InterPro:IPR006090"
FT /db_xref="InterPro:IPR006091"
FT /db_xref="InterPro:IPR009075"
FT /db_xref="InterPro:IPR009100"
FT /db_xref="InterPro:IPR013764"
FT /db_xref="InterPro:IPR013786"
FT /db_xref="UniProtKB/TrEMBL:O53158"
FT /protein_id="CAA15996.1"
FT /translation="MGHYIANVRDLEFNLLEVLDIGAVLGTGRYSDLDVDTVRTILAEA
FT ARLAEGPIAESFGYADRNPPVFDPNTHSISVPDELAKTVQAIKEAGWWRLGLAEEIGGM
FT PAPPPLAWAVNEMIYCANPSACFFNLGPVLAQSLYIEGNDEQRRWAAEGVQRGWQATMV
FT LTEPDAGSDVGAGRTKAFEQPDGTWHIEGVKRFISGGDVGNTAENIFHLVLARPEGAGP
FT GTKGLSLFYVPNYLFDPDTFELGARNGVYVTGLEHKMGLKSSPTCELTFGGADVPAVGY
FT LVGGVHNGIAQMFTVIEHARMTIGVKSAGTLSTGYLNALAFAKERVQGADLTQMTDKTA
FT PRVTIMHHPDVRRSLMTQKAYAEGLRALYLYAAAHQDDAVAQRVSGADHDMAHRVDDLL
FT LPIVKGVGSERAYEILTESLQTLGGSGFLVDYPLEQYIRDAKIDSLYEGTTAIQALDFF
FT FRKIVRDHGKALQFVLAQVTHTVENIDPSLKPQAELLRTALDDITAMTGALTGYLMSAA
FT QHSSDIYKVGLGSVRYLLAVGDLLIGWRLLVLAGVAHAALADGPSQNDEAFYRGKIAVA
FT AFFAKNMLPKLTGVRSVIENIDDDIMRVPEDAF"
FT CDS complement(272566..273678)
FT /transl_table=11
FT /gene="PE_PGRS29"
FT /locus_tag="Rv1468c"
FT /product="PE-PGRS FAMILY PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1468c, (MTV007.15c), len: 370 aa. Member of the
FT Mycobacterium tuberculosis PE family, PGRS subfamily of
FT gly-rich proteins (see citation below). TBparse score is
FT 0.856."
FT /db_xref="InterPro:IPR000084"
FT /db_xref="UniProtKB/TrEMBL:Q79FP0"
FT /protein_id="CAE55392.1"
FT /translation="MSFVVANTEFVSGAAGNLARLGSMISAANSAAAAQTTAVAAAGAD
FT EVSAAVAALFGAHGQTYQVLSAQAAAFHSQFVQALSGGAQAYAAAEATNFGPLQPLFDV
FT INAPTLALLNRPLIGNGADGTAANPNGQAGGLLIGNGGNGFSPAAGPGGNGGAAGLLGH
FT GGNGGVGALGANGGAGGTGGWLFGNGGAGGNSGGGGGAGGIGGSAVLFGAGGAGGISPN
FT GMGAGGSGGNGGLFFGNGGAGASSFLGGGGAGGRAFLFGDGGAGGAALSAGSAGRGGDA
FT GFFYGNGGAGGSGAGGASSAHGGAGGQAGLFGNGGEGGDGGALGGNGGNGGNAQLIGNG
FT GDGGDGGGAGAPGLGGRGGLLLGLPGANGT"
FT CDS 273920..275893
FT /transl_table=11
FT /gene="ctpD"
FT /locus_tag="Rv1469"
FT /product="PROBABLE CATION TRANSPORTER P-TYPE ATPASE D CTPD"
FT /function="CATION-TRANSPORTING ATPASE; POSSIBLY CATALYZES
FT THE TRANSPORT OF A CATION (POSSIBLY CADMIUM) WITH THE
FT HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O +
FT CATION(IN) = ADP + PHOSPHATE + CATION(OUT)]."
FT /EC_number="3.6.3.-"
FT /note="Rv1469, (MTV007.16), len: 657 aa. Probable ctpD,
FT cation-transporting P-type ATPase D (transmembrane protein)
FT (EC 3.6.3.-), highly similar to others e.g. T35947 probable
FT cation-transporting ATPase from Streptomyces coelicolor
FT (638 aa); NP_442633.1|NC_000911 cation-transporting ATPase
FT (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (642
FT aa), FASTA scores: opt: 1438, E(): 0, (41.9% identity in
FT 592 aa overlap); NP_389268.1|NC_000964 protein similar to
FT heavy metal-transporting ATPase from Bacillus subtilis (637
FT aa); etc. Also highly similar to others from Mycobacterium
FT tuberculosis e.g. Rv3743c|MTV025.091c|CTPJ (660 aa).
FT Contains PS00154 E1-E2 ATPases phosphorylation site.
FT BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2
FT ATPASES), SUBFAMILY IB. TBparse score is 0.907."
FT /db_xref="GOA:P63685"
FT /db_xref="InterPro:IPR001366"
FT /db_xref="InterPro:IPR001757"
FT /db_xref="InterPro:IPR005834"
FT /db_xref="InterPro:IPR006404"
FT /db_xref="InterPro:IPR006416"
FT /db_xref="InterPro:IPR008250"
FT /db_xref="InterPro:IPR018303"
FT /db_xref="UniProtKB/Swiss-Prot:P63685"
FT /protein_id="CAA15997.1"
FT /translation="MTLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVAL
FT LLFLAGLVAQLNGAPEAMWWTLYLACYLAGGWGSAWAGAQALRNKALDVDLLMIAAAVG
FT AVAIGQIFDGALLIVIFATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSERVVA
FT ASELVVGDRVVVRPGDRIPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGTVNGS
FT GVLHLVVTRDPSQTVVARIVELVADASATKAKTQLFIEKIEQRYSLGMVAATLALIVIP
FT LMFGADLRPVLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVVERLAD
FT TSIVALDKTGTLTRGIPRLASVAPLDPNVVDARRLLQLAAAAEQSSEHPLGRAIVAEAR
FT RRGIAIPPAKDFRAVPGCGVHALVGNDFVEIASPQSYRGAPLAELAPLLSAGATAAIVL
FT LDGVAIGVLGLTDQLRPDAVESVAAMAALTAAPPVLLTGDNGRAAWRVARNAGITDVRA
FT ALLPEQKVEVVRNLQAGGHQVLLVGDGVNDAPAMAAARAAVAMGAGADLTLQTADGVTI
FT RDELHTIPTIIGLARQARRVVTVNLAIAATFIAVLVLWDLFGQLPLPLGVVGHEGSTVL
FT VALNGMRLLTNRSWRAAASAAR"
FT misc_feature 274958..274978
FT /note="PS00154 E1-E2 ATPases phosphorylation site"
FT CDS 275937..276311
FT /transl_table=11
FT /gene="trxA"
FT /locus_tag="Rv1470"
FT /product="PROBABLE THIOREDOXIN TRXA"
FT /function="THIOREDOXIN PARTICIPATES IN VARIOUS REDOX
FT REACTIONS THROUGH THE REVERSIBLE OXIDATION OF ITS ACTIVE
FT CENTER DITHIOL, TO A DISULFIDE, & CATALYZES
FT DITHIOL-DISULFIDE EXCHANGE REACTIONS"
FT /EC_number="1.-.-.-"
FT /note="Rv1470, (MTV007.17), len: 124 aa. Probable trxA,
FT thioredoxin (EC 1.-.-.-), similar to many e.g.
FT P12243|THI1_SYNP7 THIOREDOXIN 1 from Synechococcus sp. (106
FT aa), FASTA scores: opt: 201, E(): 9.2e-08, (35.4% identity
FT in 99 aa overlap); etc. Highly similar to downstream ORF
FT Rv1471|trxB1 probable thioredoxin from Mycobacterium
FT tuberculosis (123 aa), FASTA scores: opt: 402, E(): 0,
FT (54.4% identity in 114 aa overlap). TBparse score is 0.925.
FT Warning: note that Rv3914|MT4033|MTV028.05|trxC can be
FT alternatively named trxA."
FT /db_xref="GOA:O53161"
FT /db_xref="HSSP:1NSW"
FT /db_xref="InterPro:IPR012335"
FT /db_xref="InterPro:IPR012336"
FT /db_xref="InterPro:IPR013766"
FT /db_xref="InterPro:IPR015467"
FT /db_xref="InterPro:IPR017936"
FT /db_xref="UniProtKB/TrEMBL:O53161"
FT /protein_id="CAA15998.1"
FT /translation="MTTRDLTAAYFQQTISANSNVLVYFWAPLCAPCDLFTPTYEASSR
FT KHFDVVHGKVNIETEKDLASIAGVKLLPTLMAFKKGKLVFKQAGIANPAIMDNLVQQLR
FT AYTFKSPAGEGIGPGTKTSS"
FT CDS 276327..276698
FT /transl_table=11
FT /gene="trxB1"
FT /locus_tag="Rv1471"
FT /standard_name="trxB"
FT /product="PROBABLE THIOREDOXIN TRXB1"
FT /function="THIOREDOXIN PARTICIPATES IN VARIOUS REDOX
FT REACTIONS THROUGH THE REVERSIBLE OXIDATION OF ITS ACTIVE
FT CENTER DITHIOL, TO A DISULFIDE, & CATALYZES
FT DITHIOL-DISULFIDE EXCHANGE REACTIONS."
FT /EC_number="1.-.-.-"
FT /note="Rv1471, (MTV007.18), len: 123 aa. Probable trxB1,
FT thioredoxin (EC 1.-.-.-), similar to many bacterial
FT thioredoxins e.g. P33636|THI2_ECOLI from Escherichia coli
FT (139 aa), FASTA scores: opt: 290, E(): 1.8e-13, (44.3%
FT identity in 97 aa overlap); etc. Highly similar to
FT Rv1470|TrxA probable thioredoxin from Mycobacterium
FT tuberculosis (124 aa), FASTA scores: opt: 402, E():
FT 1.2e-32, (54.4% identity in 114 aa overlap). Contains
FT PS00194 Thioredoxin family active site. BELONGS TO THE
FT THIOREDOXIN FAMILY. TBparse score is 0.882. Note that
FT previously known as trxB."
FT /db_xref="GOA:Q7D8E1"
FT /db_xref="HSSP:1KEB"
FT /db_xref="InterPro:IPR005746"
FT /db_xref="InterPro:IPR006662"
FT /db_xref="InterPro:IPR012335"
FT /db_xref="InterPro:IPR012336"
FT /db_xref="InterPro:IPR013766"
FT /db_xref="InterPro:IPR015467"
FT /db_xref="InterPro:IPR017936"
FT /db_xref="InterPro:IPR017937"
FT /db_xref="UniProtKB/TrEMBL:Q7D8E1"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55393.1"
FT /translation="MTTRDLTAAQFNETIQSSDMVLVDYWASWCGPCRAFAPTFAESSE
FT KHPDVVHAKVDTEAERELAAAAQIRSIPTIMAFKNGKLLFNQAGALPPAALESLVQQLK
FT AYEVEAGEATTQNGRAQQA"
FT misc_feature 276390..276446
FT /note="PS00194 Thioredoxin family active site"
FT CDS 276720..277577
FT /transl_table=11
FT /gene="echA12"
FT /locus_tag="Rv1472"
FT /product="POSSIBLE ENOYL-CoA HYDRATASE ECHA12 (ENOYL
FT HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)"
FT /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING
FT SPECIFIC COMPONENTS (BY SIMILARITY) [CATALYTIC ACTIVITY:
FT (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]."
FT /EC_number="4.2.1.17"
FT /note="Rv1472, (MTV007.19), len: 285 aa. Possible echA12,
FT enoyl-CoA hydratase (EC 4.2.1.17), highly similar to
FT P53526|ECHH_MYCLE|NP_301896.1|NC_002677 possible enoyl-CoA
FT hydratase/isomerase from Mycobacterium leprae (294 aa),
FT FASTA scores: opt: 1265, E(): 0, (72.0% identity in 271 aa
FT overlap). Also similar to others e.g. CAA66096.1|X97452
FT enoyl-CoA isomerase from Escherichia coli strain K12 (262
FT aa); CAC44593.1|AL596162 putative enoyl-CoA hydratase from
FT Streptomyces coelicolor (275 aa); etc. Also similar to
FT others from Mycobacterium tuberculosis e.g.
FT ECHA16|Rv2831|MTCY16B7.11c (249 aa), FASTA scores: opt:
FT 232, E(): 1.3e-15, (33.8% identity in 204 aa overlap); etc.
FT TBparse score is 0.916."
FT /db_xref="GOA:O53163"
FT /db_xref="InterPro:IPR001753"
FT /db_xref="InterPro:IPR018376"
FT /db_xref="UniProtKB/Swiss-Prot:O53163"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA16000.1"
FT /translation="MPHRCAAQVVAGYRSTVSLVLVEHPRPEIAQITLNRPERMNSMAF
FT DVMVPLKEALAQVSYDNSVRVVVLTGAGRGFSPGADHKSAGVVPHVENLTRPTYALRSM
FT ELLDDVILMLRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSAYFRAAGINNGLTAS
FT ELGLSYLLPRAIGSSRAFEIMLTGRDVSAEEAERIGLVSRQVPDEQLLDACYAIAARMA
FT GFSRPGIELTKRTLWSGLDAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQRAPVF
FT TDDT"
FT misc_feature 277083..277145
FT /note="PS00166 Enoyl-CoA hydratase/isomerase signature"
FT CDS 277613..279241
FT /transl_table=11
FT /locus_tag="Rv1473"
FT /product="PROBABLE MACROLIDE-TRANSPORT ATP-BINDING PROTEIN
FT ABC TRANSPORTER"
FT /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF
FT MACROLIDE ACROSS THE MEMBRANE (EXPORT). MACROLIDE
FT ANTIBIOTICS RESISTANCE BY AN EXPORT MECHANISM. RESPONSIBLE
FT FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM."
FT /note="Rv1473, (MTV007.20), len: 542 aa. Possible
FT macrolide-transport ATP-binding protein ABC transporter
FT (see citation below), possibly in EF-3 subfamily. Similar
FT to many ABC-transporters e.g. D90909_48|YHES_HAEIN from
FT Synechocystis sp. strain PCC6803 (574 aa), FASTA scores:
FT opt: 870, E(): 0, (33.3% identity in 525 aa overlap);
FT P44808|YHES_HAEIN from Haemophilus influenzae (638 aa),
FT FASTA scores: opt: 706, E(): 0, (33.7% identity in 517 aa
FT overlap); etc. Contains two PS00017 ATP/GTP-binding site
FT motif A (P-loop), and two PS00211 ABC transporter family
FT signatures. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN
FT FAMILY (ABC TRANSPORTERS). TBparse score is 0.888."
FT /db_xref="GOA:O53164"
FT /db_xref="HSSP:1US8"
FT /db_xref="InterPro:IPR003439"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR017871"
FT /db_xref="UniProtKB/TrEMBL:O53164"
FT /protein_id="CAA16001.1"
FT /translation="MITATDLEVRAGARILLAPDGPDLRVQPGDRIGLVGRNGAGKTTT
FT LRILAGEVEPYAGSVTRAGEIGYLPQDPKVGDLDVLARDRVLSARGLDVLLTDLEKQQA
FT LMAEVADEDERDRAIRRYGQLEERFVALGGYGAESEAGRICASLGLPERVLTQRLRTLS
FT GGQRRRVELARILFAASESGAGNSTTLLLDEPTNHLDADSLGWLRDFLRLHTGGLVVIS
FT HNVDLVADVVNKVWFLDAVRGQVDVYNMGWQRYVDARATDEQRRIRERANAERKAAALR
FT AQAAKLGAKATKAVAAQNMLRRADRMMAALDEERVADKVARIKFPTPAACGRTPLVANG
FT LGKTYGSLEVFTGVDLAIDRGSRVVILGLNGAGKTTLLRLLAGVEQPDTGVLEPGYGLR
FT IGYFAQEHDTLDNDATVWENVRHAAPDAGEQDLRGLLGAFMFTGPQLEQPAGTLSGGEK
FT TRLALAGLVASTANVLLLDEPTNNLDPASREQVLDALRSYRGAVVLVTHDPGAAAALGP
FT QRVVLLPDGTEDYWSDEYRDLIELA"
FT misc_feature 277718..277741
FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT misc_feature 278096..278140
FT /note="PS00211 ABC transporters family signature"
FT misc_feature 278714..278737
FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
FT misc_feature 278969..279013
FT /note="PS00211 ABC transporters family signature"
FT CDS 279338..279529
FT /transl_table=11
FT /locus_tag="Rv1473A"
FT /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1473A, len: 63 aa. Possible transcriptional
FT regulator, CDS predicted by GC plot. Similar to
FT SCI8.24c|AL132644_24 putative transcriptional regulator
FT from Streptomyces coelicolor (73 aa), FASTA scores: opt:
FT 210, E(): 1.5e-08, (56.15% identity in 57 aa overlap)."
FT /db_xref="UniProtKB/TrEMBL:Q8VK14"
FT /protein_id="CAE55394.1"
FT /translation="MRKSKKTRDQLLRELRNAYEGGASIRNLAATTGRSYGSIHSMLRE
FT SGTTMRGRGGPNRRSRPR"
FT CDS complement(279598..280161)
FT /transl_table=11
FT /locus_tag="Rv1474c"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1474c, (MTV007.21c), len: 187 aa. Probable
FT transcription regulator, equivalent to AF0021|AF002133_1
FT transcriptional regulator from Mycobacterium avium strain
FT GIR10 (82 aa), FASTA scores: opt: 490, E(): 6.7e-26, (92.5%
FT identity in 80 aa overlap). Also similar to
FT Q59431|UIDR_ECOLI UID OPERON REPRESSOR (GUS OPERON) from
FT Escherichia coli (196 aa), FASTA scores: opt: 192, E():
FT 5.8e-06, (28.5% identity in 172 aa overlap). BELONGS TO THE
FT TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Helix turn
FT helix motif predicted at aa 33-54 (+3.40 SD)."
FT /db_xref="GOA:O53165"
FT /db_xref="HSSP:1BJY"
FT /db_xref="InterPro:IPR001647"
FT /db_xref="InterPro:IPR009057"
FT /db_xref="InterPro:IPR012287"
FT /db_xref="UniProtKB/TrEMBL:O53165"
FT /protein_id="CAA16002.1"
FT /translation="MPKVSEDHLAARRRQILDGARRCFAEYGYDKATVRRLEQAIGMSR
FT GAIFHHFRDKDALFFALAREDTERMAAVASREGLIGVMRDMLAAPDQFDWLATRLEIAR
FT KLRNDPDFSRGWAERSAELAAATTDRLRRQKQANRVRDDVPSDVLRCYLDLVLDGLLAR
FT LASGEDPQRLAAVLDLVENSVRRS"
FT CDS complement(280172..283003)
FT /transl_table=11
FT /gene="acn"
FT /locus_tag="Rv1475c"
FT /product="PROBABLE IRON-REGULATED ACONITATE HYDRATASE ACN
FT (Citrate hydro-lyase) (Aconitase)"
FT /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE [CATALYTIC
FT ACTIVITY: Citrate = cis-aconitate + H2O]"
FT /EC_number="4.2.1.3"
FT /note="Rv1475c, (MTV007.22c), len: 943 aa. Probable acn,
FT iron-regulated aconitate hydratase (EC 4.2.1.3), similar to
FT many e.g. P70920|ACON_BRAJA ACONITATE HYDRATASE from
FT Bradyrhizobium japonicum (906 aa), FASTA scores: opt:1912,
FT E(): 0, (54.8% identity in 958 aa overlap); closest to
FT AF0021|AF002133_2 Mycobacterium avium strain GIR10 (961
FT aa), FASTA scores: opt: 5072, E(): 0, (82.8% identity in
FT 943 aa overlap). NOTE ACONITASE HAS AN ACTIVE (4FE-4S) AND
FT AN INACTIVE (3FE-4S) FORMS. THE ACTIVE (4FE-4S) CLUSTER IS
FT PART OF THE CATALYTIC SITE THAT INTERCONVERTS CITRATE,
FT CIS-ACONITASE, AND ISOCITRATE. TBparse score is 0.889."
FT /db_xref="GOA:O53166"
FT /db_xref="HSSP:1AMJ"
FT /db_xref="InterPro:IPR000573"
FT /db_xref="InterPro:IPR001030"
FT /db_xref="InterPro:IPR006249"
FT /db_xref="InterPro:IPR015928"
FT /db_xref="InterPro:IPR015931"
FT /db_xref="InterPro:IPR015932"
FT /db_xref="InterPro:IPR015934"
FT /db_xref="InterPro:IPR015937"
FT /db_xref="InterPro:IPR018136"
FT /db_xref="UniProtKB/TrEMBL:O53166"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA16003.1"
FT /translation="MTSKSVNSFGAHDTLKVGEKSYQIYRLDAVPNTAKLPYSLKVLAE
FT NLLRNEDGSNITKDHIEAIANWDPKAEPSIEIQYTPARVVMQDFTGVPCIVDLATMREA
FT IADLGGNPDKVNPLAPADLVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQG
FT AFDDFKVVPPGTGIVHQVNIEYLASVVMTRDGVAYPDTCVGTDSHTTMVNGLGVLGWGV
FT GGIEAEAAMLGQPVSMLIPRVVGFRLTGEIQPGVTATDVVLTVTEMLRQHGVVGKFVEF
FT YGEGVAEVPLANRATLGNMSPEFGSTAAIFPIDEETIKYLRFTGRTPEQVALVEAYAKA
FT QGMWHDPKHEPEFSEYLELNLSDVVPSIAGPKRPQDRIALAQAKSTFREQIYHYVGNGS
FT PDSPHDPHSKLDEVVEETFPASDPGQLTFANDDVATDETVHSAAAHADGRVSNPVRVKS
FT DELGEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVEKGLTSKPWVKTTIAPGS
FT QVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISKAVNDNDLSVTAVLSG
FT NRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFDFQTQPLGQDKDGKNVFLRDIWPSQ
FT QDVSDTIAAAINQEMFTRNYADVFKGDDRWRNLPTPSGNTFEWDPNSTYVRKPPYFEGM
FT TAKPEPVGNISGARVLALLGDSVTTDHISPAGAIKPGTPAARYLDEHGVDRKDYNSFGS
FT RRGNHEVMIRGTFANIRLRNQLLDDVSGGYTRDFTQPGGPQAFIYDAAQNYAAQHIPLV
FT VFGGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGMGVIPLQFPEGKSASS
FT LGLDGTEVFDITGIDVLNDGKTPKTVCVQATKGDGATIEFDAVVRIDTPGEADYYRNGG
FT ILQYVLRNILKSG"
FT CDS 283161..283721
FT /transl_table=11
FT /locus_tag="Rv1476"
FT /product="POSSIBLE MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1476, (MTV007.23), len: 186 aa. Possibly membrane
FT protein, TMhelix 138-60. TBparse score is 0.926."
FT /db_xref="UniProtKB/TrEMBL:O53167"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAA16004.1"
FT /translation="MTGPYFPQTIPFLPSYIPQDVDMTAVKAEVAALGVSAPPAATPGL
FT LEVVQHARDEGIDLKIVLLDHNPPNDTPLRDIATVVGADYSDATVLVLSPNYVGSYSTQ
FT YPRVTLEAGEDHSKTGNPVQSAQNFVHELSTPEFPWSALTIVLLIGVLAAAVGARLMQL
FT RGRRSATSTDAAPGAGDDLNQGV"
FT CDS 283947..285365
FT /transl_table=11
FT /locus_tag="Rv1477"
FT /product="HYPOTHETICAL INVASION PROTEIN"
FT /function="UNKNOWN, BUT SUPPOSED INVOLVED IN VIRULENCE"
FT /note="Rv1477, (MTV007.24), len: 472 aa. Hypothetical
FT Invasion protein. Possibly exported protein with unusually
FT long signal sequence. The last 277 residues are nearly
FT identical to those of AF0060|AF006054_1 hypothetical
FT invasion protein INV1 from Mycobacterium tuberculosis (277
FT aa), FASTA scores: opt: 1833, E(): 0, (98.2% identity in
FT 277 aa overlap); also very similar to AF0021|AF002133_4
FT invasin 1 protein from Mycobacterium avium (273 aa), FASTA
FT scores: opt: 1452, E(): 0, (78.1% identity in 279 aa
FT overlap). Similar to Rv1566c|MTCY336.37|Z95586
FT Mycobacterium tuberculosis cosmid (230 aa), FASTA scores:
FT opt: 528, E(): 4.4e-20, (52.0% identity in 150 aa overlap);
FT and weakly similar to p60 proteins of Listeria spp
FT throughout its length e.g. M80351|LISIAPB_1 Listeria
FT monocytogenes iap-related protein (478 aa), FASTA scores:
FT opt: 251, E(): 8e-06, (24.4% identity in 487 aa overlap).
FT C-terminal domain highly similar to next orf
FT Rv1478|MTV007.25."
FT /db_xref="InterPro:IPR000064"
FT /db_xref="UniProtKB/TrEMBL:O53168"
FT /protein_id="CAA16005.1"
FT /translation="MRRNRRGSPARPAARFVRPAIPSALSVALLVCTPGLATADPQTDT
FT IAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVSQRAVKD
FT ANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAAKTLSASSQAVMANLQ
FT RARTERVNTESAARLAKQKADKAAADAKASQDAAVAALTETRRKFDEQREEVQRLAAER
FT DAAQARLQAARLVAWSSEGGQGAPPFRMWDPGSGPAGGRAWDGLWDPTLPMIPSANIPG
FT DPIAVVNQVLGISATSAQVTANMGRKFLEQLGILQPTDTGITNAPAGSAQGRIPRVYGR
FT QASEYVIRRGMSQIGVPYSWGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLP
FT HYSGSQYNLGRKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVR
FT TAGMTPYVVRYIEY"
FT CDS 285376..286101
FT /transl_table=11
FT /locus_tag="Rv1478"
FT /product="HYPOTHETICAL INVASION PROTEIN"
FT /function="UNKNOWN, BUT SUPPOSED INVOLVED IN VIRULENCE"
FT /note="Rv1478, (MTV007.25), len: 241 aa. Hypothetical
FT Invasion protein. Possibly exported protein, nearly
FT identical to AF0060|AF006054_2 hypothetical invasion
FT protein INV2 of Mycobacterium tuberculosis (240 aa), FASTA
FT scores: opt: 1509, E(): 0, (95.0% identity in 241 aa
FT overlap); very similar to AF0021|AF002133_5 hypothetical
FT invasion protein INV2 from Mycobacterium avium (244 aa),
FT FASTA scores: opt: 1269, E():0, (78.0% identity in 246 aa
FT overlap). Also similar to Mycobacterium tuberculosis
FT protein MTCY336.37 and weakly similar to C-terminal segment
FT of p60 proteins of Listeria spp.e.g. Q01836|P60_LISIN
FT PROTEIN P60 PRECURSOR (481 aa), FASTA scores: opt: 241,
FT E():4e-07, (37.7% identity in 122 aa overlap). Highly
FT similar to C-terminal domain of preceeding ORF
FT Rv1477|MTV007.24 (472 aa), FASTA scores: opt: 864, E(): 0,
FT (60.1% identity in 213 aa overlap). TBparse score is
FT 0.910."
FT /db_xref="InterPro:IPR000064"
FT /db_xref="UniProtKB/TrEMBL:O53169"
FT /protein_id="CAA16006.1"
FT /translation="MRHTRFHPIKLAWITAVVAGLMVGVATPADAEPGQWDPTLPALVS
FT AGAPGDPLAVANASLQATAQATQTTLDLGRQFLGGLGINLGGPAASAPSAATTGASRIP
FT RANARQAVEYVIRRAGSQMGVPYSWGGGSLQGPSKGVDSGANTVGFDCSGLVRYAFAGV
FT GVLIPRFSGDQYNAGRHVPPAEAKRGDLIFYGPGGGQHVTLYLGNGQMLEASGSAGKVT
FT VSPVRKAGMTPFVTRIIEY"
FT CDS 286240..287373
FT /transl_table=11
FT /gene="moxR1"
FT /locus_tag="Rv1479"
FT /standard_name="moxR"
FT /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
FT MOXR1"
FT /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM"
FT /note="Rv1479, (MTV007.26), len: 377 aa. Probable moxR1,
FT transcriptional regulatory protein, similar to
FT X96434|BBGIDBMOX_2 moxR regulator from Borrelia burgdorferi
FT (329 aa), FASTA scores: opt: 850, E():0, (43.5% identity in
FT 317 aa overlap); and P. denitrificans. Highly similar to
FT MoxR homologs of Mycobacterium tuberculosis and
FT Mycobacterium avium (but these both differ at C-terminus)
FT e.g. Rv3692, Rv3164c, and AF0021|AF002133_6 Mycobacterium
FT avium strain GIR10 (309 aa), FASTA scores: opt: 1181, E():
FT 0, (83.7% identity in 227 aa overlap). Also similar to
FT O33173|AF006054 MoxR fragment from Mycobacterium
FT tuberculosis (211 aa), FASTA scores: opt: 1305, E(): 0,
FT (94.3% identity in 212 aa overlap). TBparse score is 0.889.
FT Note that previously known as moxR."
FT /db_xref="GOA:Q79FN7"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="InterPro:IPR011703"
FT /db_xref="InterPro:IPR016366"
FT /db_xref="UniProtKB/TrEMBL:Q79FN7"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55395.1"
FT /translation="MTSAGGFPAGAGGYQTPGGHSASPAHEAPPGGAEGLAAEVHTLER
FT AIFEVKRIIVGQDQLVERMLVGLLSKGHVLLEGVPGVAKTLAVETFARVVGGTFSRIQF
FT TPDLVPTDIIGTRIYRQGREEFDTELGPVVANFLLADEINRAPAKVQSALLEVMQERHV
FT SIGGRTFPMPSPFLVMATQNPIEHEGVYPLPEAQRDRFLFKINVGYPSPEEEREIIYRM
FT GVTPPQAKQILSTGDLLRLQEIAANNFVHHALVDYVVRVVFATRKPEQLGMNDVKSWVA
FT FGASPRASLGIIAAARSLALVRGRDYVIPQDVIEVIPDVLRHRLVLTYDALADEISPEI
FT VINRVLQTVALPQVNAVPQQGHSVPPVMQAAAAASGR"
FT CDS 287370..288323
FT /transl_table=11
FT /locus_tag="Rv1480"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1480, (MTV007.27,MTCY227.01), len: 317 aa.
FT Conserved hypothetical protein, last 110 aa residues
FT correspond to first 110 aa of YS01_MYCAV|O07394
FT hypothetical 18.7 kDa Mycobacterium avium protein MAV169
FT (169 aa), FASTA scores: opt: 642, E(): 0, (84.2% identity
FT in 114 aa overlap). Also similar to Mycobacterium
FT tuberculosis hypothetical proteins Rv3163c and Rv3693.
FT TBparse score is 0.886."
FT /db_xref="InterPro:IPR002035"
FT /db_xref="InterPro:IPR002881"
FT /db_xref="UniProtKB/Swiss-Prot:P64853"
FT /protein_id="CAA16010.1"
FT /translation="MTESKAPAVVHPPSMLRGDIDDPKLAAALRTLELTVKQKLDGVLH
FT GDHLGLIPGPGSEPGESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVVDM
FT SASLDFGTACCEKRDLAVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQHQHT
FT MLRTIATMPQAPAGVRGDLAVAIDALRRPERRRGMAVIISDFLGPINWMRPLRAIAARH
FT EVLAIEVLDPRDVELPDVGDVVLQDAESGVVREFSIDPALRDDFARAAAAHRADVARTI
FT RGCGAPLLSLRTDRDWLADIVRFVASRRRGALAGHQ"
FT CDS 288334..289341
FT /transl_table=11
FT /locus_tag="Rv1481"
FT /product="PROBABLE MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1481, (MTCY277.02), len: 335 aa. Probable membrane
FT protein, highly similar to YS02_MYCAV|O07395 hypothetical
FT 36.1 kDa protein mav335 from Mycobacterium avium (335 aa),
FT FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa
FT overlap). Similar to AF116251|AF116251_1 BatA protein from
FT Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E():
FT 2e-12, (26.5% identity in 340 aa overlap)."
FT /db_xref="GOA:P64855"
FT /db_xref="InterPro:IPR002035"
FT /db_xref="UniProtKB/Swiss-Prot:P64855"
FT /protein_id="CAA16011.1"
FT /translation="MTLPLLGPMTLSGFAHSWFFLFLFVVAGLVALYILMQLARQRRML
FT RFANMELLESVAPKRPSRWRHVPAILLVLSLLLFTIAMAGPTHDVRIPRNRAVVMLVID
FT VSQSMRATDVEPSRMVAAQEAAKQFADELTPGINLGLIAYAGTATVLVSPTTNREATKN
FT ALDKLQFADRTATGEAIFTALQAIATVGAVIGGGDTPPPARIVLFSDGKETMPTNPDNP
FT KGAYTAARTAKDQGVPISTISFGTPYGFVEINDQRQPVPVDDETMKKVAQLSGGNSYNA
FT ATLAELRAVYSSLQQQIGYETIKGDASVGWLRLGALALALAALAALLINRRLPT"
FT CDS complement(289414..290256)
FT /transl_table=11
FT /locus_tag="Rv1482c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1482c, (MTCY277.03c), len: 280 aa. Conserved
FT hypothetical protein, highly similar to O07396|AF002133
FT Mycobacterium avium protein MAV346 (346 aa), FASTA scores:
FT E(): 0, (65.2% identity in 342 aa overlap); slight
FT similarity to GRPE_ECOLI|P09372 heat shock protein from E.
FT coli (197 aa), FASTA scores: opt: 139, E(): 0.012, (28.3%
FT identity in 159 aa overlap). Similar to Mycobacterium
FT tuberculosis hypothetical proteins Rv3517, Rv3555c,
FT Rv3714c, Rv1073, etc. Start changed since first submission
FT (-59 aa)."
FT /db_xref="UniProtKB/TrEMBL:P71763"
FT /protein_id="CAB02032.2"
FT /translation="MTDPFLGSEALAAGVLTPYELRSRYVALHKDVYVPQGVELTAQLR
FT AKALWLRSRRRGVLAGYSASAFHGAKWIDADLPAAIIDTNRRRAPGLQVWEERIEPDEI
FT CVIEGMRVTTPERTALDLTSRFPLDPAVAAVDALIQATDLKVADVEPLIERYRGRRGMK
FT AARAALDLVDGGAQSPKETWLRLLLIRAGFPRPQTQIAVRNEWGWAEAHLDMGWQDIKV
FT AAEYDGDHHLTSRYHYRKDILRHEKVQHRYGWIVVRVVAEDHPADIIRRVGEARAFRA"
FT CDS 290397..291140
FT /transl_table=11
FT /gene="fabG1"
FT /locus_tag="Rv1483"
FT /standard_name="mabA"
FT /product="3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1
FT (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID
FT BIOSYNTHESIS A PROTEIN)"
FT /function="INVOLVED IN THE FATTY ACID BIOSYNTHESIS PATHWAY
FT (FIRST REDUCTION STEP) (MYCOLIC ACID BIOSYNTHESIS); REDUCES
FT KASA/KASB PRODUCTS [CATALYTIC ACTIVITY:
FT (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ =
FT 3-oxoacyl-[acyl-carrier protein] + NADPH]."
FT /EC_number="1.1.1.100"
FT /note="Rv1483, (MTCY277.04), len: 247 aa. fabG1 (alternate
FT gene name: mabA), 3-oxoacyl-[acyl-carrier protein]
FT reductase (EC 1.1.1.100) (see citations below), equivalent
FT to O07399|FABG_MYCAV 3-OXOACYL-[ACYL-CARRIER PROTEIN]
FT REDUCTASE from Mycobacterium avium (255 aa);
FT P71534|FABG_MYCSM 3-OXOACYL-[ACYL-CARRIER PROTEIN]
FT REDUCTASE from Mycobacterium smegmatis (255 aa); and
FT NP_302228.1|NC_002677 3-oxoacyl-[ACP] reductase (aka MabA)
FT from Mycobacterium leprae (253 aa). Also highly similar to
FT many e.g. T36779 probable 3-oxacyl-(acyl-carrier-protein)
FT reductase from Streptomyces coelicolor (234 aa);
FT FABG_ECOLI|P25716|NP_415611.1|NC_000913
FT 3-oxoacyl-[acyl-carrier-protein] reductase from Escherichia
FT coli strain K12 (244 aa), FASTA scores: opt: 664, E():
FT 6.8e-35, (44.4% identity in 241 aa overlap); etc. Contains
FT PS00061 Short-chain dehydrogenases/reductases family
FT signature. BELONGS TO THE SHORT-CHAIN
FT DEHYDROGENASES/REDUCTASES (SDR) FAMILY."
FT /db_xref="GOA:P0A5Y4"
FT /db_xref="InterPro:IPR002198"
FT /db_xref="InterPro:IPR002347"
FT /db_xref="InterPro:IPR011284"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="PDB:1UZL"
FT /db_xref="PDB:1UZM"
FT /db_xref="PDB:1UZN"
FT /db_xref="PDB:2NTN"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5Y4"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02033.1"
FT /translation="MTATATEGAKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAVT
FT HRGSGAPKGLFGVECDVTDSDAVDRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEK
FT FEKVINANLTGAFRVAQRASRSMQRNKFGRMIFIGSVSGSWGIGNQANYAASKAGVIGM
FT ARSIARELSKANVTANVVAPGYIDTDMTRALDERIQQGALQFIPAKRVGTPAEVAGVVS
FT FLASEDASYISGAVIPVDGGMGMGH"
FT misc_feature 290814..290900
FT /note="PS00061 Short-chain alcohol dehydrogenase family
FT signature"
FT CDS 291159..291968
FT /transl_table=11
FT /gene="inhA"
FT /locus_tag="Rv1484"
FT /product="NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN]
FT REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)"
FT /function="THIS ISOZYME IS INVOLVED IN MYCOLIC ACID
FT BIOSYNTHESIS. SECOND REDUCTIVE STEP IN FATTY ACID
FT BIOSYNTHESIS. INVOLVED IN THE RESISTANCE AGAINST THE
FT ANTITUBERCULOSIS DRUGS ISONIAZID AND ETHIONAMIDE [CATALYTIC
FT ACTIVITY: ACYL-[ACYL-CARRIER PROTEIN] + NAD(+) =
FT TRANS-2,3-DEHYDROACYL-[ACYL-CARRIER PROTEIN] + NADH]."
FT /EC_number="1.3.1.9"
FT /note="Rv1484, (MTCY277.05), len: 269 aa. inhA,
FT NADH-dependent enoyl-[acyl-carrier-protein] reductase (EC
FT 1.3.1.9) (see citations below). Identical to
FT INHA_MYCTU|P46533 enoyl-[acyl-carrier-protein] reductase
FT from Mycobacterium tuberculosis and G1155270 Mycobacterium
FT bovis enoyl acp reductase. SOME SIMILARITY TO THE
FT SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY."
FT /db_xref="GOA:P0A5Y6"
FT /db_xref="InterPro:IPR002198"
FT /db_xref="InterPro:IPR014358"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="PDB:1BVR"
FT /db_xref="PDB:1ENY"
FT /db_xref="PDB:1ENZ"
FT /db_xref="PDB:1P44"
FT /db_xref="PDB:1P45"
FT /db_xref="PDB:1ZID"
FT /db_xref="PDB:2AQ8"
FT /db_xref="PDB:2AQH"
FT /db_xref="PDB:2AQI"
FT /db_xref="PDB:2AQK"
FT /db_xref="PDB:2B35"
FT /db_xref="PDB:2B36"
FT /db_xref="PDB:2B37"
FT /db_xref="PDB:2H7I"
FT /db_xref="PDB:2H7L"
FT /db_xref="PDB:2H7M"
FT /db_xref="PDB:2H7N"
FT /db_xref="PDB:2H7P"
FT /db_xref="PDB:2H9I"
FT /db_xref="PDB:2IDZ"
FT /db_xref="PDB:2IE0"
FT /db_xref="PDB:2IEB"
FT /db_xref="PDB:2IED"
FT /db_xref="PDB:2NSD"
FT /db_xref="PDB:2NTJ"
FT /db_xref="PDB:2NV6"
FT /db_xref="PDB:2PR2"
FT /db_xref="PDB:3FNE"
FT /db_xref="PDB:3FNF"
FT /db_xref="PDB:3FNG"
FT /db_xref="PDB:3FNH"
FT /db_xref="UniProtKB/Swiss-Prot:P0A5Y6"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02034.1"
FT /translation="MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLR
FT LIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMG
FT INPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTV
FT AKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGW
FT DQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL"
FT CDS 291974..293008
FT /transl_table=11
FT /gene="hemZ"
FT /locus_tag="Rv1485"
FT /product="FERROCHELATASE HEMZ (PROTOHEME FERRO-LYASE) (HEME
FT SYNTHETASE)"
FT /function="INVOLVED IN PROTOHEME BIOSYNTHESIS (LAST STEP).
FT CATALYZES THE INSERTION OF FERROUS IRON INTO PROTOPORPHYRIN
FT IX TO FORM PROTOHEME [CATALYTIC ACTIVITY : PROTOPORPHYRIN +
FT FE(2+) = PROTOHEME + 2 H(+)]."
FT /EC_number="4.99.1.1"
FT /note="Rv1485, (MTCY277.06), len: 344 aa. hemZ,
FT ferrochelatase (EC 4.99.1.1) (see citation below), similar
FT to many e.g. HEMZ_BACSU|P32396 ferrochelatase from Bacillus
FT subtilus (310 aa), FASTA scores: opt:490, E(): 2e-24,
FT (30.2% identity in 295 aa overlap); etc. BELONGS TO THE
FT FERROCHELATASE FAMILY."
FT /db_xref="GOA:P0A576"
FT /db_xref="InterPro:IPR001015"
FT /db_xref="InterPro:IPR019772"
FT /db_xref="UniProtKB/Swiss-Prot:P0A576"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02035.1"
FT /translation="MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHY
FT LHFGGVSPINGINRTLIAELEAQQELPVYFGNRNWEPYVEDAVTAMRDNGVRRAAVFAT
FT SAWSGYSSCTQYVEDIARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAATVRG
FT DARLVFTAHSIPTAADRRCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPW
FT LEPDVTDQLTGLAGAGINAVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTP
FT NADPRFARLARGLIDELRYGRIPARVSGPDPVPGCLSSINGQPCRPPHCVASVSPARPS
FT AGSP"
FT CDS complement(292974..293840)
FT /transl_table=11
FT /locus_tag="Rv1486c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1486c, (MTCY277.07c), len: 288 aa. Conserved
FT hypothetical protein, highly similar to YS07_MYCAV|O07402
FT hypothetical 33.5 kDa protein mav321 from Mycobacterium
FT avium (320 aa), FASTA scores: opt: 1217, E(): 0, (71.1%
FT identity in 315 aa overlap). Weak similarity to
FT AL079332|SCI5.07 hypothetical protein from Streptomyces
FT coelicolor (259 aa), FASTA scores: opt: 131, E(): 0.29,
FT (32.3% identity in 279 aa overlap). Start changed since
FT original submission."
FT /db_xref="UniProtKB/Swiss-Prot:P71766"
FT /protein_id="CAB02036.2"
FT /translation="MWCPSVSLSIWANAWLAGKAAPDDVLDALSLWAPTQSVAAYDAVA
FT AGHTGLPWPDVHDAGTVSLLQTLRAAVGRRRLRGTINVVLPVPGDVRGLAAGTQFEHDA
FT LAAGEAVIVANPEDPGSAVGLVPEFSYGDVDEAAQSEPLTPELCALSWMVYSLPGAPVL
FT EHYELGDAEYALRSAVRSAAEALSTIGLGSSDVAKPRGLVEQLLESSRQHRVPDHAPSR
FT ALRVLENAAHVDAIIAVSAGLSRLPIGTQSLSDAQRATDALRPLTAVVRSARMSAVTAI
FT LHSAWPD"
FT CDS 293898..294332
FT /transl_table=11
FT /locus_tag="Rv1487"
FT /product="CONSERVED MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1487, (MTCY277.08), len: 144 aa. Conserved
FT membrane protein. Highly similar to O07404|AF002133 MAV145
FT from Mycobacterium avium (145 aa), FASTA scores: opt: 667,
FT E(): 0, (72.5% identity in 142 aa overlap). Also similar to
FT AL079332|SCI5.05 hypothetical protein from Streptomyces
FT coelicolor (143 aa), FASTA scores: opt: 344, E(): 1.3e-15,
FT (44.8% identity in 134 aa overlap)."
FT /db_xref="InterPro:IPR002810"
FT /db_xref="UniProtKB/TrEMBL:P71767"
FT /protein_id="CAB02037.1"
FT /translation="MPVALIWLIAALVLVGAEALTGDMFLLMLGGGALAASVSSWLLAW
FT PMWADGAVFLLVSVLLLVLVRPAVRRRLTQTKGVQLGIEALEGKKAVVLGRVARDGGQV
FT KLDGQVWTARPLNDGDVFEPGDSVTVVQIDGATAVVFKDV"
FT CDS 294354..295499
FT /transl_table=11
FT /locus_tag="Rv1488"
FT /product="POSSIBLE EXPORTED CONSERVED PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1488, (MTCY277.09), len: 381 aa. Possible exported
FT conserved protein; contains possible N-terminal signal
FT sequence. Similar to YBBK_ECOLI|P77367 hypothetical protein
FT ybbK from Escherichia coli (305 aa), FASTA scores: opt:
FT 716, E(): 0, (37.1% identity in 307 aa overlap). Similar to
FT stomatin-like proteins e.g. AF065260|AF065260_1 Clostridium
FT difficile (320 aa), FASTA scores: opt: 767, E(): 0, (42.3%
FT identity in 307 aa overlap)."
FT /db_xref="GOA:P63693"
FT /db_xref="InterPro:IPR001107"
FT /db_xref="InterPro:IPR001972"
FT /db_xref="InterPro:IPR018080"
FT /db_xref="UniProtKB/Swiss-Prot:P63693"
FT /protein_id="CAB02038.1"
FT /translation="MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSR
FT TVSGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQAAV
FT YEISNYIVGVEQLTTTTLRNVVGGMTLEQTLTSRDQINAQLRGVLDEATGRWGLRVARV
FT ELRSIDPPPSIQASMEKQMKADREKRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQ
FT AAILAAEADRQSRMLRAQGERAAAYLQAQGQAKAIEKTFAAIKAGRPTPEMLAYQYLQT
FT LPEMARGDANKVWVVPSDFNAALQGFTRLLGKPGEDGVFRFEPSPVEDQPKHAADGDDA
FT EVAGWFSTDTDPSIARAVATAEAIARKPVEGSLGTPPRLTQ"
FT CDS 295509..295865
FT /transl_table=11
FT /locus_tag="Rv1489"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1489, len: 118 aa. Conserved hypothetical protein,
FT similar to hypothetical proteins from Mycobacterium avium
FT subsp. paratuberculosis and Streptomyces coelicolor e.g.
FT AJ250017_1 insertion sequence IS900, Locus 3, putative
FT invasion protein from M. paratuberculosis (138 aa), FASTA
FT scores: opt: 120, E(): 0.26, (34.375% identity in 96 aa
FT overlap); SCD6.11c|AL353815_11 possible integral membrane
FT protein from Streptomyces coelicolor (136 aa), FASTA
FT scores: opt: 106, E(): 2.2, (35.9% identity in 103 aa
FT overlap). ORF predicted by GC plot. Replaces previous
FT Rv1489c on other strand."
FT /db_xref="UniProtKB/TrEMBL:Q8VK13"
FT /protein_id="CAE55396.1"
FT /translation="MSGLTSPKTYAVLAALQAGDAVACAIPLPPIARLLDDLDVPVSVR
FT PVLPVVKAASAVGLLSVTRFPALARLTTAMLTLYFILAVGAHVRVRDRVVNAIPAASFL
FT TLFALMTAKGPERT"
FT CDS 295899..296129
FT /transl_table=11
FT /locus_tag="Rv1489A"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1489A, len: 76 aa. Conserved hypothetical protein,
FT similar to part of alpha subunit of many methylmalonyl-CoA
FT mutases (~750 aa). Size difference suggests possible gene
FT fragment although Mycobacterium tuberculosis has intact
FT methylmalonyl-CoA mutase gene. P71774|MUTB_MYCTU PROBABLE
FT METHYLMALONYL-CoA MUTASE from Mycobacterium tuberculosis
FT (750 aa), FASTA scores: opt: 258, E(): 3.2e-10, (73.35%
FT identity in 60 aa overlap). ORF predicted by GC plot."
FT /db_xref="GOA:Q8VK12"
FT /db_xref="HSSP:1REQ"
FT /db_xref="InterPro:IPR006099"
FT /db_xref="UniProtKB/TrEMBL:Q8VK12"
FT /protein_id="CAE55397.1"
FT /translation="MSVGEVEVLKVENSRVRAEQLAKLYELRSSRDRVRVDAALAELSR
FT AAAARGCAGTSGLGNNLMAPGPPHSLLGRDR"
FT CDS 296279..297586
FT /transl_table=11
FT /locus_tag="Rv1490"
FT /product="PROBABLE MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1490, (MTCY277.12), len: 435 aa. Probable membrane
FT protein."
FT /db_xref="GOA:P64857"
FT /db_xref="UniProtKB/Swiss-Prot:P64857"
FT /protein_id="CAB02040.1"
FT /translation="MSQCFAVKGIGGADQATLGSAEILVKYAQLADKRARVYVLVSTWL
FT VVWGIWHVYFVEAVFPNAILWLHYYAASYEFGFVRRGLGGELIRMLTGDHFFAGAYTVL
FT WTSITVWLIALAVVVWLILSTGNRSERRIMLALLVPVLPFAFSYAIYNPHPELFGMTAL
FT VAFSIFLTRAHTSRTRVILSTLYGLTMAVLALIHEAIPLEFALGAVLAIIVLSKNATGA
FT TRRICTALAIGPGTVSVLLLAVVGRRDIADQLCAHIPHGMVENPWAVATTPQRVLDYIF
FT GRVESHADYHDWVCEHVTPWFNLDWITSAKLVAVVGFRALFGAFLLGLLFFVATTSMIR
FT YVSAVPVRTFFAELRGNLALPVLASALLVPLFITAVDWTRWWVMITLDVAIVYILYAID
FT RPEIEQPPSRRNVQVFVCVVLVLAVIPTGSANNIGR"
FT CDS complement(298165..298923)
FT /transl_table=11
FT /locus_tag="Rv1491c"
FT /product="CONSERVED MEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1491c, (MTCY277.13c), len: 252 aa. Conserved
FT membrane protein. Similar to hypothetical proteins from
FT many organisms e.g. YDJZ_ECOLI|P76221 Escherichia coli (235
FT aa), FASTA scores: opt: 223, E():6.7 e-07, (31.7% identity
FT in 145 aa overlap); AL133252|SCE46.15 Streptomyces
FT coelicolor (249 aa), FASTA scores: opt: 378, E(): 1.5e-17,
FT (39.1% identity in 169 aa overlap). Also similar to
FT Mycobacterium tuberculosis hypothetical protein Rv0625c."
FT /db_xref="GOA:P67117"
FT /db_xref="InterPro:IPR015414"
FT /db_xref="UniProtKB/Swiss-Prot:P67117"
FT /protein_id="CAB02041.1"
FT /translation="MTAPAICNTTETVHGIATSLGAVARQASLPRIVGTVVGITVLVVV
FT ALLVPVPTAVELRDWAKSLGAWFPLAFLLVHTVVTVPPFPRTAFTLAAGLLFGSVVGVF
FT IAVVGSTASAVIAMLLVRATGWQLNSLVRRRAINRLDERLRERGWLAILSLRLIPVVPF
FT AAINYAAGASGVRILSFAWATLAGLLPGTAAVVILGDAFAGSGSPLLILVSVCTGALGL
FT TGLVYEIRNYRRQHRRMPGYDDPVREPALI"
FT CDS 299114..300961
FT /transl_table=11
FT /gene="mutA"
FT /locus_tag="Rv1492"
FT /product="PROBABLE METHYLMALONYL-CoA MUTASE SMALL SUBUNIT
FT MUTA (MCM)"
FT /function="INVOLVED IN PROPIONIC ACID FERMENTATION.
FT CATALYZES THE ISOMERIZATION OF SUCCINYL-CoA TO
FT METHYLMALONYL-CoA DURING SYNTHESIS OF PROPIONATE FROM
FT TRICARBOXYLIC ACID-CYCLE INTERMEDIATES [CATALYTIC ACTIVITY:
FT (R)-2-METHYL-3-OXOPROPANOYL-CoA = SUCCINYL- COA]"
FT /EC_number="5.4.99.2"
FT /note="Rv1492, (MTCY277.14), len: 615 aa. Probable mutA,
FT Methylmalonyl-CoA mutase small-subunit (EC 5.4.99.2),
FT strong similarity to e.g. MUTA_STRCM|Q05064
FT methylmalonyl-CoA mutase beta-subunit from Streptomyces
FT cinnamonensis (616 aa), FASTA scores: opt: 1512, E(): 0,
FT (45.9% identity in 628 aa overlap). Contains PS00213
FT Lipocalin signature, PS00544 Methylmalonyl-CoA mutase
FT signature. BELONGS TO THE METHYLMALONYL-CoA MUTASE FAMILY."
FT /db_xref="GOA:P65485"
FT /db_xref="InterPro:IPR004608"
FT /db_xref="InterPro:IPR006099"
FT /db_xref="InterPro:IPR014348"
FT /db_xref="InterPro:IPR016176"
FT /db_xref="UniProtKB/Swiss-Prot:P65485"
FT /protein_id="CAB02042.1"
FT /translation="MSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLL
FT DTQTADGFAIRALYTAFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATAD
FT TNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACDVM
FT LALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDG
FT PAFHNLGATAATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKM
FT RALRQLWARVAEVVGDPGGGAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAGVGGADT
FT VLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRL
FT ARRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPA
FT LPPGDPTSPVRRYAAGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLL
FT ASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICGTDARYRDEVADIVQAARAAGVSRV
FT YLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA"
FT misc_feature 299141..299176
FT /note="PS00213 Lipocalin signature"
FT misc_feature 300203..300280
FT /note="PS00544 Methylmalonyl-CoA mutase signature"
FT CDS 300962..303214
FT /transl_table=11
FT /gene="mutB"
FT /locus_tag="Rv1493"
FT /product="PROBABLE METHYLMALONYL-CoA MUTASE LARGE SUBUNIT
FT MUTB (MCM)"
FT /function="INVOLVED IN PROPIONIC ACID FERMENTATION.
FT CATALYZES THE ISOMERIZATION OF SUCCINYL-CoA TO
FT METHYLMALONYL-CoA DURING SYNTHESIS OF PROPIONATE FROM
FT TRICARBOXYLIC ACID-CYCLE INTERMEDIATES [CATALYTIC ACTIVITY
FT : (R)-2-METHYL-3-OXOPROPANOYL-CoA = SUCCINYL- COA.]"
FT /EC_number="5.4.99.2"
FT /note="Rv1493, (MTCY277.15), len: 750 aa. Probable mutB,
FT Methylmalonyl-CoA mutase large-subunit (EC 5.4.99.2),
FT strong similarity to e.g. MUTB_STRCM|Q05065
FT methylmalonyl-CoA mutase alpha-subunit from Streptomyces
FT cinnamonensis (733 aa), FASTA scores: opt: 3562, E(): 0,
FT (75.8% identity in 730 aa overlap). Contains PS00544
FT Methylmalonyl-CoA mutase signature. BELONGS TO THE
FT METHYLMALONYL-CoA MUTASE FAMILY."
FT /db_xref="GOA:P65487"
FT /db_xref="InterPro:IPR006098"
FT /db_xref="InterPro:IPR006099"
FT /db_xref="InterPro:IPR006158"
FT /db_xref="InterPro:IPR006159"
FT /db_xref="InterPro:IPR014348"
FT /db_xref="InterPro:IPR016176"
FT /db_xref="PDB:1SE5"
FT /db_xref="UniProtKB/Swiss-Prot:P65487"
FT /protein_id="CAB02043.1"
FT /translation="MTTKTPVIGSFAGVPLHSERAAQSPTEAAVHTHVAAAAAAHGYTP
FT EQLVWHTPEGIDVTPVYIAADRAAAEAEGYPLHSFPGEPPFVRGPYPTMYVNQPWTIRQ
FT YAGFSTAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSIL
FT DMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILKEFMV
FT RNTYIYPPKPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVD
FT YIRAGLNAGLDIDSFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAQFAPKSAKSLS
FT LRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIA
FT RNTQLVLQQESGTTRPIDPWGGSYYVEWLTHRLARRARAHIAEVAEHGGMAQAISDGIP
FT KLRIEEAAARTQARIDSGQQPVVGVNKYQVPEDHEIEVLKVENSRVRAEQLAKLQRLRA
FT GRDEPAVRAALAELTRAAAEQGRAGADGLGNNLLALAIDAARAQATVGEISEALEKVYG
FT RHRAEIRTISGVYRDEVGKAPNIAAATELVEKFAEADGRRPRILIAKMGQDGHDRGQKV
FT IATAFADIGFDVDVGSLFSTPEEVARQAADNDVHVIGVSSLAAGHLTLVPALRDALAQV
FT GRPDIMIVVGGVIPPGDFDELYAAGATAIFPPGTVIADAAIDLLHRLAERLGYTLD"
FT misc_feature 302150..302227
FT /note="PS00544 Methylmalonyl-CoA mutase signature"
FT CDS 303228..303530
FT /transl_table=11
FT /locus_tag="Rv1494"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1494, (MTCY277.16), len: 100 aa. Hypothetical
FT unknown protein."
FT /db_xref="UniProtKB/Swiss-Prot:P0A5E9"
FT /protein_id="CAB02044.1"
FT /translation="MPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAA
FT IVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYESEAERSAARARRNARQQRSAQ"
FT CDS 303527..303844
FT /transl_table=11
FT /locus_tag="Rv1495"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1495, (MTCY277.17), len: 105 aa. Conserved
FT hypothetical protein, some similarity to
FT Rv1942c|MTCY09F9.22 hypothetical protein from Mycobacterium
FT tuberculosis (109 aa) (0.7% identity in 101 aa overlap) and
FT Rv0659c, Rv1102c."
FT /db_xref="GOA:P64859"
FT /db_xref="InterPro:IPR003477"
FT /db_xref="InterPro:IPR011067"
FT /db_xref="UniProtKB/Swiss-Prot:P64859"
FT /protein_id="CAB02045.1"
FT /translation="MNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTR
FT RTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDYLGEVTPATMNKINTALATALGLPW
FT P"
FT CDS 303841..304845
FT /transl_table=11
FT /locus_tag="Rv1496"
FT /product="Possible transport system kinase"
FT /function="possibly involved in transport (possibly
FT arginine)"
FT /EC_number="2.7.-.-"
FT /note="Rv1496, (MTCY277.18), len: 334 aa. Possible
FT transport system kinase (EC 2.7.-.-). Equivalent to
FT NP_302220.1|NC_002677 putative kinase from Mycobacterium
FT leprae (327 aa). Highly similar to several transport system
FT kinases and NTPase transporters e.g.
FT P27254|ARGK_ECOLI|B2918 LAO/AO transport system kinase (EC
FT 2.7.-.-) from Escherichia coli K12 (331 aa) (see citation
FT below); NP_311815.1|NC_002695 ATPase component of two
FT convergent arginine transporter from Escherichia coli
FT O157:H7 (331 aa); etc. Also similar to YPLE_CAUCR|P37895
FT hypothetical 34.6 kDa protein in Caulobacter crescentus
FT (326 aa), FASTA scores, opt: 1125, E(): 0, (55.7% identity
FT in 316 aa overlap)."
FT /db_xref="GOA:P63577"
FT /db_xref="InterPro:IPR005129"
FT /db_xref="UniProtKB/Swiss-Prot:P63577"
FT /protein_id="CAB02046.1"
FT /translation="MMAASHDDDTVDGLATAVRGGDRAALPRAITLVESTRPDHREQAQ
FT QLLLRLLPDSGNAHRVGITGVPGVGKSTAIEALGMHLIERGHRVAVLAVDPSSTRTGGS
FT ILGDKTRMARLAVHPNAYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETVGVGQ
FT SEVAVANMVDTFVLLTLARTGDQLQGIKKGVLELADIVVVNKADGEHHKEARLAARELS
FT AAIRLIYPREALWRPPVLTMSAVEGRGLAELWDTVERHRQVLTGAGEFDARRRDQQVDW
FT TWQLVRDAVLDRVWSNPTVRKVRSELERRVRAGELTPALAAQQILEIANLTDR"
FT CDS 304898..306187
FT /transl_table=11
FT /gene="lipL"
FT /locus_tag="Rv1497"
FT /product="PROBABLE ESTERASE LIPL"
FT /function="UNKNOWN, BUT SUPPOSED INVOLVEMENT IN LIPID
FT METABOLISM"
FT /EC_number="3.1.-.-"
FT /note="Rv1497, (MTCY277.19), len: 429 aa. Probable LipL,
FT esterase (EC 3.1.-.-), very similar to Mycobacterium
FT tuberculosis hypothetical esterases and penicillin binding
FT proteins e.g. Rv1923, Rv2463, Rv3775, etc. Also similar to
FT G151214|M68491 esterase estA from Pseudomonas sp (389 aa),
FT FASTA scores: opt: 604, E(): 1e-31, (34.4% identity in 389
FT aa overlap)."
FT /db_xref="GOA:P71778"
FT /db_xref="InterPro:IPR001466"
FT /db_xref="InterPro:IPR012338"
FT /db_xref="UniProtKB/TrEMBL:P71778"
FT /protein_id="CAB02047.1"
FT /translation="MMVDTGVDHRAVSSHDGPDAGRRVFGAADPRFACVVRAFASMFPG
FT RRFGGGALAVYLDGQPVVDVWKGWADRAGWVPWSADSAPMVFSATKGMTATVIHRLADR
FT GLIDYEAPVAEYWPAFGANGKATLTVRDVMRHQAGLSGLRGATQQDLLDHVVMEERLAA
FT AVPGRLLGKSAYHALTFGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRPPADA
FT PTRVAEIIMPQDIAANAVLTCAMRRLAHRFSGGFRSMYFPGAIAAVQGEAPLLDAEIPA
FT ANGVATARALARMYGAIANGGEIDGIRFLSRELVTGLTRNRRQVLPDRNLLVPLNFHLG
FT YHGMPIGNVMPGFGHVGLGGSIGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLI
FT RQAAAQARKRGYQPVTPFGAPYSEPGAAAG"
FT CDS complement(306260..306877)
FT /transl_table=11
FT /locus_tag="Rv1498c"
FT /product="PROBABLE METHYLTRANSFERASE"
FT /function="CAUSES METHYLATION"
FT /EC_number="2.1.1.-"
FT /note="Rv1498c, (MTCY277.20c), len: 205 aa. Probable
FT methyltransferase (EC 2.1.1.-). Similar to
FT G2792343|AF040571 METHYLTRANSFERASE from AMYCOLATOPSIS
FT MEDITERRANEI (272 aa), FASTA scores: E(): 5.1e-11, (32.3%
FT identity in 124 aa overlap). Contains PS00017
FT ATP/GTP-binding site motif A."
FT /db_xref="GOA:P71779"
FT /db_xref="InterPro:IPR013216"
FT /db_xref="UniProtKB/Swiss-Prot:P71779"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02048.1"
FT /translation="MLDVGCGSGRMALPLTGYLNSEGRYAGFDISQKAIAWCQEHITSA
FT HPNFQFEVSDIYNSLYNPKGKYQSLDFRFPYPDASFDVVFLTSVFTHMFPPDVEHYLDE
FT ISRVLKPGGRCLCTYFLLNDESLAHIAEGKSAHNFQHEGPGYRTIHKKRPEEAIGLPET
FT FVRDVYGKFGLAVHEPLHYGSWSGREPRLSFQDIVIATKTAS"
FT misc_feature complement(306473..306496)
FT /note="PS00017 ATP/GTP-binding site motif A"
FT CDS complement(307091..307303)
FT /transl_table=11
FT /locus_tag="Rv1498A"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1498A, len: 70 aa. Conserved hypothetical protein,
FT highly similar to other hypothetical proteins e.g. from
FT Streptomyces coelicolor, Sinorhizobium meliloti and
FT Pseudomonas aeruginosa."
FT /db_xref="InterPro:IPR009923"
FT /db_xref="UniProtKB/TrEMBL:Q8VK10"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAE55398.1"
FT /translation="MSNHTYRVIEIVGTSPDGVDAAIQGGLARAAQTMRALDWFEVQSI
FT RGHLVDGAVAHFQVTMKVGFRLEDS"
FT CDS 307364..307762
FT /transl_table=11
FT /locus_tag="Rv1499"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1499, (MTCY277.21), len: 132 aa. Hypothetical
FT unknown protein; was initially longer but has been
FT shortened (-24 aa) owing to overlap with Rv1498A."
FT /db_xref="UniProtKB/TrEMBL:P71780"
FT /protein_id="CAB02049.2"
FT /translation="MPSGEPSTAGHFEHLPRGSFGRILSVLNAAADHHPRELLVVGIAT
FT FDQKRPAVGVDEHDPGGAATPAVVINYESRSSAGGTIGHSTTSQVACCLYQQPKRPALR
FT PTKAAATTAATTWIERVQNRRGRHSALV"
FT CDS 307807..308835
FT /transl_table=11
FT /locus_tag="Rv1500"
FT /product="PROBABLE GLYCOSYLTRANSFERASE"
FT /function="UNKNOWN"
FT /EC_number="2.-.-.-"
FT /note="Rv1500, (MTCY277.22), len: 342 aa. Probable
FT glycosyltransferase (EC 2.-.-.- ), hydrophobic domain near
FT C-terminus. Some similarity to putative
FT glycosyl-transferases from Bacillus subtilis e.g.
FT O34319|YKCC_BACSU (323 aa), opt: 490, E(): 6.1e-25, (28.85%
FT identity in 312 aa overlap) and to N-acetyl glucosamine
FT transferases. Also similar to G1001347 hypothetical 36.7
FT kDa protein (318 aa), FASTA scores: opt: 523, E(): 7.2e-26,
FT (30.6% identity in 307 aa overlap)."
FT /db_xref="GOA:P71781"
FT /db_xref="InterPro:IPR001173"
FT /db_xref="UniProtKB/TrEMBL:P71781"
FT /protein_id="CAB02014.1"
FT /translation="MRLSIVTTMYMSEPYVLEFYRRARAAADKITPDVEIIFVDDGSPD
FT AALQQAVSLLDSDPCVRVIQLSRNFGHHKAMMTGLAHATGDLVFLIDSDLEEDPALLEP
FT FYEKLISTGADVVFGCHARRPGGWLRNFGPKIHYRASALLCDPPLHENTLTVRLMTADY
FT VRSLVQHQERELSIAGLWQITGFYQVPMSVNKAWKGTTTYTFRRKVATLVDNVTSFSNK
FT PLVFIFYLGAAIFIISSSAAGYLIIDRIFFRALQAGWASVIVSIWMLGGVTIFCIGLVG
FT IYVSKVFIETKQRPYTIIRRIYGSDLTTREPSSLKTAFPAAHLSNGKRVTSEPEGLATG
FT NR"
FT CDS 308847..309668
FT /transl_table=11
FT /locus_tag="Rv1501"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1501, (MTCY277.23), len: 273 aa. Conserved
FT hypothetical protein, some similarity to
FT O06374|Rv3633|MTCY15C10.19C hypothetical protein from
FT Mycobacterium tuberculosis, FASTA scores: E(): 3.9e-10,
FT (27.5% identity in 280 aa overlap)."
FT /db_xref="InterPro:IPR008775"
FT /db_xref="UniProtKB/Swiss-Prot:P67770"
FT /protein_id="CAB02015.1"
FT /translation="MIPVKVENNTSLDQVQDALNCVGYAVVEDVLDEASLAATRDRMYR
FT VQERILTEIGKERLARAGELGVLRLMMKYDPHFFTFLEIPEVLSIVDRVLSETAILHLQ
FT NGFILPSFPPFSTPDVFQNAFHQDFPRVLSGYIASVNIMFAIDPFTRDTGATLVVPGSH
FT QRIEKPDHTYLARNAVPVQCAAGSLFVFDSTLWHAAGRNTSGKDRLAINHQFTRSFFKQ
FT QIDYVRALGDAVVLEQPARTQQLLGWYSRVVTNLDEYYQPPDKRLYRKGQG"
FT CDS 309881..310780
FT /transl_table=11
FT /locus_tag="Rv1502"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1502, (MTCY277.24), len: 299 aa. Hypothetical
FT unknown protein."
FT /db_xref="UniProtKB/Swiss-Prot:P71783"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02016.1"
FT /translation="MAWRKLGRIFAPSGELDWSRSHAALPVPEWIEGDIFRIYFSGRDG
FT QNRSSIGSVIVDLAVGGKILDIPAEPILRPGARGMFDDCGVSIGSIVRAGDTRLLYYTG
FT WNLAVTVPWKNTIGVAISEAGAPFERWSTFPVVALDERDPFSLSYPWVIQDGGTYRMWY
FT GSNLGWGEGTDEIPHVIRYAQSRDGVHWEKQDRVHIDTSGSDNSAACRPYVVRDAGVYR
FT MWFCARGAKYRIYCATSEDGLTWRQLGKDEGIDVSPDSWDSDMIEYPCVFDHRGQRFML
FT YSGDGYGRTGFGLAVLEN"
FT CDS complement(310953..>311501)
FT /transl_table=11
FT /locus_tag="Rv1503c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1503c, (MTCY277.25c), len: 182 aa. Conserved
FT hypothetical protein, similar to C-terminal region of
FT P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE BIOSYNTHESIS PROTEIN
FT from Escherichia coli (376 aa), FASTA scores: opt: 565,
FT E(): 0, (49.4% identity in 170 aa overlap); Rv1503c and
FT Rv1504c are both similar to RFFA_ECOLI but are separated by
FT a stop codon, sequence appears to be correct so possible
FT pseudogene."
FT /db_xref="GOA:Q79FN3"
FT /db_xref="InterPro:IPR000653"
FT /db_xref="InterPro:IPR015422"
FT /db_xref="InterPro:IPR015424"
FT /db_xref="UniProtKB/TrEMBL:Q79FN3"
FT /protein_id="CAB02017.1"
FT /translation="DFLLRAEILREKGTNRSRFLRNEVDKYTWQDKGSSYLPSELVAAF
FT LWAQFEEAERITRIRLDLWNRYHESFESLEQRGLLRRPIIPQGCSHNAHMYYVLLAPSA
FT DREEVLARLTSEGIGAVFHYVPLHDSPAGRRYGRTNGNLTVTNDVASRLIRLPMWVGLQ
FT EVDQSRVVEALTRILTLRA"
FT CDS complement(311502..312101)
FT /transl_table=11
FT /locus_tag="Rv1504c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1504c, (MTCY277.26c), len: 199 aa. Conserved
FT hypothetical protein, similar to N-terminal region of
FT P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE BIOSYNTHESIS PROTEIN
FT from Escherichia coli (376 aa), FASTA scores: opt: 863,
FT E(): 0, (68.0% identity in 194 aa overlap); Rv1503c and
FT Rv1504c are similar to RFFA_ECOLI but are separated by a
FT stop codon, sequence appears to be correct so possible
FT pseudogene."
FT /db_xref="GOA:Q79FN2"
FT /db_xref="HSSP:1B9H"
FT /db_xref="InterPro:IPR000653"
FT /db_xref="InterPro:IPR015421"
FT /db_xref="InterPro:IPR015424"
FT /db_xref="UniProtKB/TrEMBL:Q79FN2"
FT /protein_id="CAB02018.1"
FT /translation="MSDHKVPFNRPYMTGRELAYIAEAHSCGHLAGDGPFTRRSHAWLE
FT QQTGCRKALLTPSCTAALEMMALLLDIEEGDEVILPSYTFVSTANAFVLRGGVPVFVDI
FT RPDTLNIDETRIVDAITPRTKAIVPVHYAGVACEMDAIMKIATHHNLAVVEDAAQGAMA
FT SYRGRALGSIGDLGALSFHETKNVISGEGGALLVNS"
FT CDS complement(312238..312903)
FT /transl_table=11
FT /locus_tag="Rv1505c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1505c, (MTCY277.27c), len: 221 aa. Conserved
FT hypothetical protein, some similarity to hypothetical
FT proteins and glycosylases e.g. P71063|O08181 HYPOTHETICAL
FT 22.5 kDa PROTEIN YVFD from Bacillus subtilis (216 aa),
FT FASTA scores: E(): 2.4e-08, (25.5% identity in 196 aa
FT overlap)."
FT /db_xref="GOA:P71784"
FT /db_xref="InterPro:IPR001451"
FT /db_xref="InterPro:IPR011004"
FT /db_xref="InterPro:IPR020019"
FT /db_xref="UniProtKB/TrEMBL:P71784"
FT /protein_id="CAB02019.1"
FT /translation="MTKPLVIFGSGDIAQLAHYYFTRDSEYEVVAFTVDRDYASVSEFC
FT GLPLVAFDEVAQRFPPESHAMFVALAYAKLNGVRKEKYLAAKALGYELASYVSSHATVL
FT NDGRIGENVFLLEDNTIQPFVSIGNNVTLWSGNHIGHHSTIHDHCFLASHIVVSGGVVI
FT EEQSFIGVNATLRDHITIGSRCVVGAGALLLGDADADGVYIGTKTERRPVPSTELRKI"
FT CDS complement(312900..313400)
FT /transl_table=11
FT /locus_tag="Rv1506c"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1506c, (MTCY277.28c), len: 166 aa. Hypothetical
FT unknown protein."
FT /db_xref="GOA:P71785"
FT /db_xref="InterPro:IPR013216"
FT /db_xref="UniProtKB/TrEMBL:P71785"
FT /protein_id="CAB02020.1"
FT /translation="MRIVNAADPFSINDLGCGYGALLDYLDARGFKTDYTGIDVSPEMV
FT RAAALRFEGRANADFICAARIDREADYSVASGIFNVRLKSLDTEWCAHIEATLDMLNAA
FT SRRGFSFNCLTSYSDASKMRDDLYYADPCALFDLCKRRYSKSVALLHDYGLYEFTILVR
FT KAS"
FT CDS complement(313684..314379)
FT /transl_table=11
FT /locus_tag="Rv1507c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1507c, (MTCY277.29c), len: 231 aa. Conserved
FT hypothetical protein. Similar to AJ007747|BBR007747_6
FT Hypothetical protein BbLPS1.06 from Bordetella
FT bronchiseptica cosmid (239 aa), FASTA scores: opt: 362,
FT E(): 1.3e-17, (30.8% identity in 221 aa overlap)."
FT /db_xref="InterPro:IPR014985"
FT /db_xref="UniProtKB/Swiss-Prot:P71786"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02021.1"
FT /translation="MKKVAIVQSNYIPWRGYFDLIAFVDEFIIYDDMQYTKRDWRNRNR
FT IKTSQGLQWITVPVQVKGRFHQKIRETLIDGTDWAKAHWRALEFNYSAAAHFAEIADWL
FT APIYLEEQHTNLSLLNRRLLNAICSYLGISTRLANSWDYELADGKTERLANLCQQAAAT
FT EYVSGPSARSYVDERVFDELSIRVTWFDYDGYRDYKQLWGGFEPAVSILDLLFNVGAEA
FT PDYLRYCRQ"
FT CDS 314313..314816
FT /transl_table=11
FT /locus_tag="Rv1507A"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1507A, len: 167 aa. Hypothetical unknow protein.
FT Shows weak similarity with C-terminus of Q9XHQ7|CDA9
FT CYTIDINE DEAMINASE 9 from Arabidopsis thaliana (Mouse-ear
FT cress) (298 aa), FASTA scores: opt: 104, E(): 4.2, (33.6%
FT identity in 133 aa overlap), BLASTP scores: Score: 77,
FT Identities: 39/133 (29%), Positives: 62/133 (46%)."
FT /db_xref="UniProtKB/TrEMBL:Q8VK09"
FT /protein_id="CAE55399.1"
FT /translation="MQSGQNILAKVCNLIEQSRLSSTRCLQFRITNTSRPRQLRWSEFK
FT RFCDIFNMVLGKARMGRDPGRPVRDERRIVSCEIIASDHIGLAAARLLAKRYRGRSVSG
FT FVLMIKSASVHEIDSWSSPSVAMSIGVALCSYPHYAAARTSPPNRDWGEDTTRSRPVTG
FT LLAG"
FT CDS complement(315052..316851)
FT /transl_table=11
FT /locus_tag="Rv1508c"
FT /product="Probable membrane protein"
FT /function="UNKNOWN"
FT /note="Rv1508c, (MTCY277.30c), len: 599 aa. Probable
FT membrane protein."
FT /db_xref="UniProtKB/TrEMBL:P71787"
FT /protein_id="CAB02022.1"
FT /translation="MIPVMSARFTGFPLLPVALRHGITSGRGCGFILDVGAQRPFGNDV
FT LLSVATRKIRSRLPGDRVGNHGALLPFRAEPRRIQMKRPPEVLRGAVTASRERLWAIGS
FT QSERTLMLGTILLASVISAATAYALSQWYAVDVFSTLLVVPGDCWLDWGMNIGRHCFSD
FT YAMVAAAGIQPNPADYLISLPADYQPTAVAAWAPARIPYAIFGLPSHWLGAPRLGLICY
FT LVALTMAVISPAIWAARGARGLERVVIFVTLGAAAIPAWGVIDRGNSTGFVVPIALAYF
FT VALSRQRWGLATITVILAVLVKPQFVVLGVVLLAARQWRWAGIGITGVVVSNIAAFLLW
FT PRGFPGTIAQSIHGIIKFNSSFGGLRDPRNVSFGKALLLIPDSIKNYQSGKIPEGFLTG
FT PRTQIGFAVLVIVVVAVLALGRRIPPVMVGIVLLATATFSPADVAFYYLVFVLPIAALV
FT ARDPNGPPGAGIFDQLAAHGDRRRAVGVCVSLAVALSIVNVAVPGQPFYVPLYGQLGAK
FT GVVGTTPLVFTTVTWAPFLWLVTCVVIIVSYARKPARPHDSHNGPTRESDQDTAASTTS
FT CLPNPVEESSPRGPGPICQNYTP"
FT CDS 316823..317185
FT /transl_table=11
FT /locus_tag="Rv1508A"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1508A, len: 120 aa. Conserved hypothetical
FT protein, highly similar to central part of glycosyl
FT transferases from various mycobacteria and eubacteria e.g.
FT P71790|MTCY277.33|Rv1511 Hypothetical protein from M.
FT tuberculosis (340 aa), FASTA scores: opt: 210, E(): 2.5
FT e-09, (42.9% identity in 105 aa overlap)."
FT /db_xref="GOA:Q79FN0"
FT /db_xref="InterPro:IPR006368"
FT /db_xref="UniProtKB/TrEMBL:Q79FN0"
FT /protein_id="CAE55400.1"
FT /translation="MKRALITGITGPDGSYLAKLPLKGYVAAGSPAEVYFCWATRNYRE
FT LYGLLAVNSIWFNHESPRHGETFMTRNPAPYRGRQRGADRCADADAPAHPDRYQYWGVP
FT ASVRGVIDRAMGVCVE"
FT CDS 317169..318050
FT /transl_table=11
FT /locus_tag="Rv1509"
FT /product="HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1509, (MTCY277.31), len: 298 aa. Hypothetical
FT unknown protein."
FT /db_xref="InterPro:IPR013217"
FT /db_xref="UniProtKB/Swiss-Prot:P71788"
FT /protein_id="CAB02023.1"
FT /translation="MFALSNNLNRVNACMDGFLARIRSHVDAHAPELRSLFDTMAAEAR
FT FARDWLSEDLARLPVGAALLEVGGGVLLLSCQLAAEGFDITAIEPTGEGFGKFRQLGDI
FT VLELAAARPTIAPCKAEDFISEKRFDFAFSLNVMEHIDLPDEAVRRVSEVLKPGASYHF
FT LCPNYVFPYEPHFNIPTFFTKELTCRVMRHRIEGNTGMDDPKGVWRSLNWITVPKVKRF
FT AAKDATLTLRFHRAMLVWMLERALTDKEFAGRRAQWMVAAIRSAVKLRVHHLAGYVPAT
FT LQPIMDVRLTKR"
FT CDS 318252..319550
FT /transl_table=11
FT /locus_tag="Rv1510"
FT /product="conserved probable membrane protein"
FT /function="UNKNOWN"
FT /note="Rv1510, (MTCY277.32), len: 432 aa. Probable membrane
FT protein. Highly similar to Rv3630|MTCY15C10.22 (431 aa),
FT FASTA scores: E(): 0, (70.8% identity in 424 aa overlap)."
FT /db_xref="GOA:P71789"
FT /db_xref="UniProtKB/Swiss-Prot:P71789"
FT /protein_id="CAB02024.1"
FT /translation="MYERRHERGMCDRAVEMTDVGATAAPTGPIARGSVARVGAATALA
FT VACVYTVIYLAARDLPPACFSIFAVFWGALGIATGATHGLLQETTREVRWVRSTQIVAG
FT HRTHPLRVAGMIGTVAAVVIAGSSPLWSRQLFVEGRWLSVGLLSVGVAGFCAQATLLGA
FT LAGVDRWTQYGSLMVTDAVIRLAVAAAAVVIGWGLAGYLWAATAGAVAWLLMLMASPTA
FT RSAASLLTPGGIATFVRGAAHSITAAGASAILVMGFPVLLKVTSDQLGAKGGAVILAVT
FT LTRAPLLVPLSAMQGNLIAHFVDRRTQRLRALIAPALVVGGIGAVGMLAAGLTGPWLLR
FT VGFGPDYQTGGALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYLLGWVSATVASTLLLL
FT LPMPLETRTVIALLFGPTVGIAIHVAALARRPD"
FT CDS 320031..321053
FT /transl_table=11
FT /gene="gmdA"
FT /locus_tag="Rv1511"
FT /product="GDP-D-mannose dehydratase gmdA (GDP-mannose 4,6
FT dehydratase) (GMD)"
FT /function="unknown, probably involved in nucleotide-sugar
FT metabolism"
FT /EC_number="4.2.1.47"
FT /note="Rv1511, (MTCY277.33), len: 340 aa. Probable gmdA,
FT GDP-D-mannose dehydratase (EC 4.2.1.47), equivalent to
FT AF125999|AF125999_13 Mycobacterium avium enzyme (343 aa),
FT FASTA scores: opt: 2085, E(): 0, (89.1% identity in 338 aa
FT overlap); similar to G755218 PSEUDOMONAS AERUGINOSA
FT GDP-D-MANNOSE DEHYDRATASE (GCA) (323 aa), FASTA scores:
FT opt: 1073, E(): 0, (51.9% identity in 320 aa overlap); and
FT to S74433 GDP-D-mannose dehydratase rfbD - Syn (362 aa),
FT FASTA scores: opt: 1405, E(): 0, (63.9% identity in 327 aa
FT overlap)."
FT /db_xref="GOA:P71790"
FT /db_xref="HSSP:1DB3"
FT /db_xref="InterPro:IPR001509"
FT /db_xref="InterPro:IPR006368"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="UniProtKB/TrEMBL:P71790"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02025.1"
FT /translation="MKRALITGITGQDGSYLAELLLAKGYEVHGLIRRASTFNTSRIDH
FT LYVDPHQPGARLFLHYGDLIDGTRLVTLLSTIEPDEVYNLAAQSHVRVSFDEPVHTGDT
FT TGMGSMRLLEAVRLSRVHCRFYQASSSEMFGASPPPQNELTPFYPRSPYGAAKVYSYWA
FT TRNYREAYGLFAVNGILFNHESPRRGETFVTRKITRAVARIKAGIQSEVYMGNLDAVRD
FT WGYAPEYVEGMWRMLQTDEPDDFVLATGRGFTVREFARAAFEHAGLDWQQYVKFDQRYL
FT RPTEVDSLIGDATKAAELLGWRASVHTDELARIMVDADMAALECEGKPWIDKPMIAGRT
FT "
FT CDS 321050..322018
FT /transl_table=11
FT /gene="epiA"
FT /locus_tag="Rv1512"
FT /product="probable nucleotide-sugar epimerase epiA"
FT /function="unknown, probably involved in nucleotide-sugar
FT metabolism"
FT /note="Rv1512, (MTCY277.34), len: 322 aa. Probable epiA,
FT NUCLEOTIDE SUGAR EPIMERASE, equivalent to
FT AJ223832|MAS223832_4 from Mycobacterium avium silvaticum
FT (339 aa), FASTA scores: opt: 1821, E(): 0, (84.6% identity
FT in 318 aa overlap); and similar to WCAG_ECOLI|P32055
FT colanic acid biosynthesis protein wcaG (321 aa), FASTA
FT scores: opt: 835, E(): 0, (53.5% identity in 316 aa
FT overlap)."
FT /db_xref="GOA:P71791"
FT /db_xref="HSSP:1E6U"
FT /db_xref="InterPro:IPR001509"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="UniProtKB/TrEMBL:P71791"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB02026.1"
FT /translation="MNAHTSVGPLDRAARVYIAGHRGLVGSALLRTFAGAGFTNLLVRS
FT RAELDLTDRAATFDFVLESRPQVVIDAAARVGGILANDTYPADFLSENLQIQVNLLDAA
FT VAARVPRLLFLGSSCIYPKLAPQPIPESALLTGPLEPTNDAYAIAKIAGILAVQAVRRQ
FT HGLPWISAMPTNLYGPGDNFSPSGSHLLPALIRRYDEAKASGAPNVTNWGTGTPRRELL
FT HVDDLASACLYLLEHFDGPTHVNVGTGIDHTIGEIAEMVASAVGYSGETRWDPSKPDGT
FT PRKLLDVSVLREAGWRPSIALRDGIEATVAWYREHAGTVRQ"
FT CDS 322015..322746
FT /transl_table=11
FT /locus_tag="Rv1513"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1513, (MTCY277.35), len: 243 aa. Conserved
FT hypothetical protein, similar to hypothetical proteins from
FT several organisms e.g. AJ223833|MAP223833_3 from
FT Mycobacterium avium paratuberculosis (240 aa), FASTA
FT scores: opt: 1053 E(): 0, (66.3% identity in 243 aa
FT overlap); P74191|SLL1173 from Synechocystis (244 aa), FASTA
FT scores: opt: 276, E(): 1.1e-07, (32.2 % identity in 202 aa
FT overlap). Also highly similar to
FT P95136|Q50460|MTCY349.33c|Rv2956 from Mycobacterium
FT tuberculosis (243 aa), (70.0% identity in 237 aa overlap)."
FT /db_xref="InterPro:IPR006342"
FT /db_xref="UniProtKB/TrEMBL:P71792"
FT /protein_id="CAB02027.1"
FT /translation="MRLARRARNILRRNGIEVSRYFAELDWERNFLRQLQSHRVSAVLD
FT VGANSGQYARGLRGAGFAGRIVSFEPLPGPFAVLQRSASTDPLWECRRCALGDVDGTIS
FT INVAGNEGASSSVLPMLKRHQDAFPPANYVGAQRVPIHRLDSVAADVLRPNDIAFLKID
FT VQGFEKQVIAGGDSTVHDRCVGMQLELSFQPLYEGGMLIREALDLVDSLGFTLSGLQPG
FT FTDPRNGRMLQADGIFFRGSD"
FT CDS complement(322764..323552)
FT /transl_table=11
FT /locus_tag="Rv1514c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1514c, (MTCY277.36c), len: 262 aa. Conserved
FT hypothetical protein. Similar to other hypothetical
FT proteins, and to WCAE_ECOLI|P71239 putative colanic acid
FT biosynthesis glycosyl transferase (248 aa), FASTA scores:
FT opt: 231, E(): 4.1e-08, (33.3% identity in 210 aa overlap).
FT Also similar to Mycobacterium tuberculosis hypothetical
FT glycosyltransferase, Rv2957."
FT /db_xref="GOA:P71793"
FT /db_xref="InterPro:IPR001173"
FT /db_xref="UniProtKB/Swiss-Prot:P71793"
FT /protein_id="CAB02028.1"
FT /translation="MTSAPTVSVITISFNDLDGLQRTVKSVRAQRYRGRIEHIVIDGGS
FT GDDVVAYLSGCEPGFAYWQSEPDGGRYDAMNQGIAHASGDLLWFLHSADRFSGPDVVAQ
FT AVEALSGKGPVSELWGFGMDRLVGLDRVRGPIPFSLRKFLAGKQVVPHQASFFGSSLVA
FT KIGGYDLDFGIAADQEFILRAALVCEPVTIRCVLCEFDTTGVGSHREPSAVFGDLRRMG
FT DLHRRYPFGGRRISHAYLRGREFYAYNSRFWENVFTRMSK"
FT CDS complement(323587..324483)
FT /transl_table=11
FT /locus_tag="Rv1515c"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1515c, (MTCY277.37c), len: 298 aa. Conserved
FT hypothetical protein, similar to
FT P71805|MTCY02B12.11C|Rv1377c Hypothetical protein from
FT Mycobacterium tuberculosis, FASTA scores: E(): 1.3e-05,
FT (25.4% identity in 134 aa overlap)."
FT /db_xref="UniProtKB/TrEMBL:P71794"
FT /protein_id="CAB02029.1"
FT /translation="MSTNPGPAEGANQVMAQEHSAGAVQFTAHNVRLDDGTLTIPESSR
FT TLDESSWFISARGILETVFPGDKSHLRLADVGCLEGGYAVGFARMGFQVLGIEVRELNM
FT AACNYIKSKTNLPNLRFVHDNALNIANHGLFDTVFCCGLFYHLENPKQYLETLSSVTNK
FT LLILQTHFSIINRSDKWLRLPTTARQLTDRLLRRPAPVKFMLSAPTEHEGLPGRWFTEF
FT SDDRSFGQRDTAKWASWDNRRSFWIQREHLLQAIKDVGVDLVMEEYDNLEPSIAESLLG
FT GSYAANLRGTFIGIKTR"
FT CDS complement(324486..325496)
FT /transl_table=11
FT /locus_tag="Rv1516c"
FT /product="probable sugar transferase"
FT /function="unknown; involved in cellular metabolism."
FT /EC_number="2.-.-.-"
FT /note="Rv1516c, (MTCY277.38c), len: 336 aa. Probable sugar
FT transferase (EC 2.-.-.-), similar to AB010970|AB010970_6
FT glycosyltransferase from Streptococcus mutans (465 aa),
FT FASTA scores: opt: 388, E(): 4.1e-18, (32.7% identity in
FT 214 aa overlap), slight similarity to SPSA_BACSU|P39621
FT spore coat polysaccharide biosynthesis (256 aa), fasta
FT scores: opt: 185, E(): 6.5e-05, (26.2% identity in 187 aa
FT overlap), strong similarity to Rv1520|MTCY19G5.08c probable
FT sugar transferase from Mycobacterium tuberculosis (63.5%
FT identity in 318 aa overlap)."
FT /db_xref="GOA:P71795"
FT /db_xref="InterPro:IPR001173"
FT /db_xref="UniProtKB/TrEMBL:P71795"
FT /protein_id="CAB02030.2"
FT /translation="MSPQLCPKVSIVSTTHNQAGYARQAFDSFLDQQTDFPVEIIVADD
FT ASTDATPAIIREYAERYPHVFRPIFRTENLGLNGNLTGALSAARGEYVALCEADDYWID
FT PLKLSKQVAFLDRHPKTTVCFHPVRVIWEDGHAKDSKFPPVRVRGNLSLDALILMNFIQ
FT TNSAVYRRLERYDDIPADVMPLDWYLHVRHAVHGDIAMLPDTMAVYRRHAQGMWHNQVV
FT DPPKFWLTQGPGHAATFDAMLDLFPGDPAREELIAVMADWILRQIANVPGPEGRAALQE
FT TIARHPRIAMLALQHRGATPARRLKTQWRKLAAATPSRRGLVDVWPSRLRRGCRA"
FT CDS 325828..326592
FT /transl_table=11
FT /locus_tag="Rv1517"
FT /product="CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1517, (MTCY277.39), len: 254 aa. Conserved
FT hypothetical transmembrane protein, similar to
FT G466802|LEPB1170_F2_64 from Mycobacterium leprae (230 aa),
FT FASTA scores: opt: 282, E(): 2.2e-11, (34.1% identity in
FT 255 aa overlap). Also similar to Mycobacterium tuberculosis
FT Rv3821|MTCY409.09c (237 aa) (36.3% identity in 256 aa
FT overlap); and Rv3481c."
FT /db_xref="GOA:P71796"
FT /db_xref="UniProtKB/TrEMBL:P71796"
FT /protein_id="CAB02031.1"
FT /translation="MWTMVLLLGLGMAIDPARLGLAVVMLSRRRPMLNLFAFWVGGMVA
FT GVGIALAVLVFMRDVALAAIQGVVSAANEFREAVGILAGGRLHIVIGVIMLLLAARMVA
FT RARAQVGVPVGPVGVADGGMSALALAQRPPGLVARLEVRTQQMLQGDVVWPAFVVGVAS
FT SAPPFESVVALTVIMASGAEIGTQLGAFVVFTLLVLAVIEIPLVAYLAIPQQTQQVMLR
FT FQDWVRSNRRQISLTILIGVGFLFLYQGVTSL"
FT CDS 326601..327560
FT /transl_table=11
FT /locus_tag="Rv1518"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="unknown, possibly glycosyl transferase"
FT /note="Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa.
FT Conserved hypothetical protein, possibly glycosyl
FT transferase involved in exopolysaccharide synthesis,
FT similar to several hypothetical proteins and glycosyl
FT transferases from diverse organisms e.g. P73996|D90911 from
FT SYNECHO CYSTIS sp. (309 aa), Fasta scores: opt: 300, E():
FT 1.8e-13, (29.5% identity in 241 aa overlap)."
FT /db_xref="GOA:Q50590"
FT /db_xref="InterPro:IPR001173"
FT /db_xref="UniProtKB/Swiss-Prot:Q50590"
FT /protein_id="CAB02050.1"
FT /translation="MVPGDASSVVSVNPAKPLISVCIPMYNNGATIERCLRSILEQEGV
FT EFEIVVVDDDSSDDCAAIAATMLRPGDRLLRNEPRLGLNRNHNKCLEVARGGLIQFVHG
FT DDRLLPGALQTLSRRFEDPSVGMAFAPRRVESDDIKWQQRYGRVHTRFRKLRDRNHGPS
FT LVLQMVLHGAKENWIGEPTAVMFRRQLALDAGGFRTDIYQLVDVDFWLRLMLRSAVCFV
FT PHELSVRRHTAATETTRVMATRRNVLDRQRILTWLIVDPLSPNSVRSAAALWWIPAWLA
FT MIVEVAVLGPQRRTHLKALAPAPFREFAHARRQLPMAD"
FT CDS 327690..327959
FT /transl_table=11
FT /locus_tag="Rv1519"
FT /product="CONSERVED HYPOTHETICAL PROTEIN"
FT /function="UNKNOWN"
FT /note="Rv1519, (MTCY19G5.09c), len: 89 aa. Conserved
FT hypothetical protein, high similarity to C-terminus of
FT Q50723|MTCY78.26|Rv3402c (412 aa) (58.1% identity in 74 aa
FT overlap)."
FT /db_xref="InterPro:IPR000653"
FT /db_xref="UniProtKB/Swiss-Prot:P64861"
FT /protein_id="CAB01397.1"
FT /translation="MRCGCLACDGVLCANGPGRPRRPALTCTAVATRTLHSLATNAELV
FT ESADLTVTEDICSRIVSLPVHDHMAIADVARVVAPFGEGLARGG"
FT CDS 327985..329025
FT /transl_table=11
FT /locus_tag="Rv1520"
FT /product="probable sugar transferase"
FT /function="unknown; thought to be involved in cellular
FT metabolism."
FT /EC_number="2.-.-.-"
FT /note="Rv1520, (MTCY19G5.08c), len: 346 aa. Probable sugar
FT transferase (EC 2.-.-.-), similar to several e.g.
FT AB010970|AB010970_6 Streptococcus mutans
FT glycosyltransferase (465 aa), FASTA scores: opt: 381, E():
FT 1.2e-18, (31.7% identity in 240 aa overlap); O34234|Y07786
FT SUGAR TRANSFERASE from Vibrio cholerae (337 aa), FASTA
FT scores: opt: 214, E(): 8.4e-05, (25.9% identity in 212 aa
FT overlap). Also strongly similar to Mycobacterium
FT tuberculosis probable sugar transferase Rv1516c."
FT /db_xref="InterPro:IPR001173"
FT /db_xref="UniProtKB/Swiss-Prot:P64863"
FT /protein_id="CAB01396.1"
FT /translation="MSIVSISYNQEEYIREALDGFAAQRTEFPVEVIIADDASTDATPR
FT IIGEYAARYPQLFRPILRQTNIGVHANFKDVLSAARGEYLALCEGDDYWTDPLKLSKQV
FT KYLDRHPETTVCFHPVRVIYEDGAKDSEFPPLSWRRDLSVDALLARNFIQTNSVVYRRQ
FT PSYDDIPANVMPIDWYLHVRHAVGGEIAMLPETMAVYRRHAHGIWHSAYTDRRKFWETR
FT GHGMAATLEAMLDLVHGHREREAIVGEVSAWVLREIGKTPGRQGRALLLKSIADHPRMT
FT MLSLQHRWAQTPWRRFKRRLSTELSSLAALAYATRRRALEGRDGGYRETTSPPTGRGRN
FT VRGSHA"
FT CDS 329259..331010
FT /transl_table=11
FT /gene="fadD25"
FT /locus_tag="Rv1521"
FT /product="PROBABLE FATTY-ACID-CoA LIGASE FADD25
FT (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)"
FT /function="UNKNOWN, BUT INVOLVEMENT IN LIPID DEGRADATION."
FT /EC_number="6.2.1.-"
FT /note="Rv1521, (MTCY19G5.07), len: 583 aa. Probable fadD25,
FT fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to
FT many e.g. P71495|U75685 ACYL-CoA SYNTHASE from
FT Mycobacterium bovis (582 aa), FASTA scores: opt: 2486, E():
FT 0, (63.4% identity in 584 aa overlap);
FT NP_301232.1|NC_002677 acyl-CoA synthetase from
FT Mycobacterium leprae (579 aa); etc. Also highly similar to
FT others from Mycobacterium tuberculosis e.g. fadD24 (584
FT aa); fadD28 (580 aa); etc."
FT /db_xref="GOA:Q50586"
FT /db_xref="InterPro:IPR000873"
FT /db_xref="UniProtKB/Swiss-Prot:Q50586"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB01395.1"
FT /translation="MSVVESSLPGVLRERASFQPNDKALTFIDYERSWDGVEETLTWSQ
FT LYRRTLNLAAQLREHGSTGDRALILAPQSLDYVVSFIASLQAGIVAVPLSIPQGGAHDE
FT RTVSVFADTAPAIVLTASSVVDNVVEYVQPQPGQNAPAVIEVDRLDLDARPSSGSRSAA
FT HGHPDILYLQYTSGSTRTPAGVMVSNKNLFANFEQIMTSYYGVYGKVAPPGSTVVSWLP
FT FYHDMGFVLGLILPILAGIPAVLTSPIGFLQRPARWIQMLASNTLAFTAAPNFAFDLAS
FT RKTKDEDMEGLDLGGVHGILNGSERVQPVTLKRFIDRFAPFNLDPKAIRPSYGMAEATV
FT YVATRKAGQPPKIVQFDPQKLPDGQAERTESDGGTPLVSYGIVDTQLVRIVDPDTGIER
FT PAGTIGEIWVHGDNVAIGYWQKPEATERTFSATIVNPSEGTPAGPWLRTGDSGFLSEGE
FT LFIMGRIKDLLIVYGRNHSPDDIEATIQTISPGRCAAIAVSEHGAEKLVAIIELKKKDE
FT SDDEAAERLGFVKREVTSAISKSHGLSVADLVLVSPGSIPITTSGKIRRAQCVELYRQD
FT EFTRLDA"
FT CDS complement(331129..334569)
FT /transl_table=11
FT /gene="mmpL12"
FT /locus_tag="Rv1522c"
FT /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT
FT PROTEIN MMPL12"
FT /function="UNKNOWN. THOUGHT TO BE INVOLVED IN FATTY ACID
FT TRANSPORT."
FT /note="Rv1522c, (MTCY19G5.06), len: 1146 aa. Probable
FT mmpL12, conserved transmembrane transport protein (see
FT Tekaia et al., 1999), member of RND superfamily. Strong
FT similarity to many Mycobacterial membrane proteins e.g.
FT Q49619|G466786 putative transport protein B1170_C1_181 from
FT Mycobacterium leprae (1008 aa), FASTA scores: opt: 2418,
FT E(): 0, (51.0% identity in 1006 aa overlap); etc. Also
FT highly similar to MmpL8|MTCY48.08c|Rv3823c PROBABLE
FT CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from
FT Mycobacterium tuberculosis, FASTA score: (34.3% identity in
FT 376 aa overlap); and some similarity to
FT MmpL10|MTCY20G9|Rv1183 PROBABLE CONSERVED TRANSMEMBRANE
FT TRANSPORT PROTEIN, FASTA score: (27.2% identity in 1011 aa
FT overlap). BELONGS TO THE MMPL FAMILY."
FT /db_xref="GOA:Q50585"
FT /db_xref="InterPro:IPR000731"
FT /db_xref="InterPro:IPR004707"
FT /db_xref="InterPro:IPR004869"
FT /db_xref="UniProtKB/Swiss-Prot:Q50585"
FT /experiment="experimental evidence, no additional details
FT recorded"
FT /protein_id="CAB01394.1"
FT /translation="MARHDEAKAGGLFDRIGNFVVRWPLIVIGCWIAVAAALTLLLPTL
FT QAQAAKREQAPLPPGAPSMVLQKEMSAAFQEKIETSALLLVLLTNENGLGPADEAVYRK
FT LIENLRADTQDKISVQDFLAVPEMKELLASKDNKAWNLPITFAGDAASPETQAAFKRVA
FT AIVKQTVAGTSLTVHLSGPIATVADLTELGEKDVRIIEIGTAVSVLIILILVYRNLVTM
FT LVPLATIGASVVTAQGTLSGLAEFGLAVNMQAIVFMSAVMIGAGTDYAVFLISRYHDYV
FT RHGEKSDMAVKKALMSIGKVITASAATVAVTFLAMVFTKLEVFSAVGPAIAVAITVSLL
FT GAVTLLPAILTLTGRRGWIKPRRDLTSRMWRRSGVRIVRRSTIHLVGSLIVLVALAGCT
FT LLIRFNYDDLKTVPQHVESVKGYEAMNRHFPMNAMTPMVLFIKSPRDLRTPGALADIEM
FT MSREIAELPNIVMVRGLTRPNGEPLKETKVSFQAGEVGGKLDEATTLLEEHGGELDQLT
FT GGAHQLADALAQIRNEINGAVASSSGIVNTLQAMMDLMGGDKTIRQLENASQYVGRMRA
FT LGDNLSGTVTDAEQIATWASPMVNALNSSPVCNSDPACRTSRAQLAAIVQAQDDGLLRS
FT IRALAVTLQQTQEYQTLARTVSTLDGQLKQVVSTLKAVDGLPTKLAQMQQGANALADGS
FT AALAAGVQELVDQVKKMGSGLNEAADFLLGIKRDADKPSMAGFNIPPQIFSRDEFKKGA
FT QIFLSADGHAARYFVQSALNPATTEAMDQVNDILRVADSARPNTELEDATIGLAGVPTA
FT |