Group Accession SAMEG165741

Submission Title:GSE43147: Genome wide maps of ZFX binding in human leukemia cell lines
Submission Identifier:GEN-SRP017686
Submission Description:Summary: Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) maintain the undifferentiated phenotype and proliferative capacity of their respective cells of origin, hematopoietic stem/progenitor cells and immature thymocytes. The mechanisms that maintain these progenitor-like characteristics are poorly understood. We report that transcription factor Zfx is required for the development and propagation of experimental AML caused by MLL-AF9 fusion, and of T-ALL caused by Notch1 activation. In both leukemia types, Zfx activated progenitor-associated gene expression programs and prevented differentiation. Key Zfx target genes included mitochondrial enzymes Ptpmt1 and Idh2, whose overexpression partially rescued the propagation of Zfx-deficient AML. These studies identify a common mechanism that controls the cell-of-origin characteristics of acute leukemias derived from disparate lineages and transformation mechanisms. Overall Design: Analysis of genomic ZFX binding in the AML cell line NOMO-1 and the T-ALL cell line RPMI-8402
Submission Release Date:2014-02-15
Submission Update Date:2014-03-01
Submission Reference Layer:false
Databases:ENA SRA Link

URI: ;

ID: SRP017686 ;

Name: GEO; Address: ; Role: Submitter; Email: ; URI:
Group Name : Other Group
Samples in group:4
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