Nwabugwu2013 - A Tumor-Immune Mathematical Model of CD4+ T Helper Cell

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Model Identifier
MODEL2007090001
Short description
<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <p>Its a mathematical model presenting the interaction between a growing tumor and immune system. Model involves tumor cells, dendritic cell, helper Tcells, regulatory Tcells, effector cells and certain cytokines (e.g. TGFbeta, IL10, IL2 ) produced by these cells. It represent a dynamic regulation of tumor production/killing by different immune cells and cytokines. Model is derived from Tessi-Roberton 2012</p> </body> </notes>
Format
SBML (L2V4)
Related Publication
  • A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation.
  • Nwabugwu CI, Rakhra K, Felsher DW, Paik DS
  • Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference , 1/ 2013 , Volume 2013 , pages: 4529-4532 , PubMed ID: 24110741
  • Electrical Engineering Department, Stanford University, Stanford CA 94305 USA;
  • Understanding the complex dynamics between the tumor cells and the host immune system will be key to improved therapeutic strategies against cancer. We propose an ODE-based mathematical model of both the tumor and immune system and how they respond to inactivation of the driving oncogene. Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts.
Contributors
Krishna Kumar Tiwari

Metadata information

hasTaxon
Taxonomy Homo sapiens
isPropertyOf
Mathematical Modelling Ontology Ordinary differential equation model
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Non-curated


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Model files

24110741_Nwabugwu.xml SBML L2V4 file 159.26 KB Preview | Download

Additional files

24110741_Nwabugwu.cps COPASI 4.27 201.21 KB Preview | Download

  • Model originally submitted by : Krishna Kumar Tiwari
  • Submitted: 09-Jul-2020 15:11:13
  • Last Modified: 09-Jul-2020 15:11:13
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 09-Jul-2020 15:11:13
    • Submitted by: Krishna Kumar Tiwari
    • With comment: Edited model metadata online.
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