Mahasa2016-tumor–immune surveillance

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Model Identifier
MODEL2003040001
Short description
We present a novel mathematical model involving various immune cell populations and tumor cellpopulations. The model describes how tumor cells evolve and survive the brief encounter with theimmune system mediated by natural killer (NK) cells and the activated CD8þcytotoxic T lymphocytes(CTLs). The model is composed of ordinary differential equations describing the interactions betweenthese important immune lymphocytes and various tumor cell populations. Based on up-to-dateknowledge of immune evasion and rational considerations, the model is designed to illustrate how tu-mors evade both arms of host immunity (i.e.innate and adaptive immunity). The model predicts that(a) an influx of an external source of NK cells might play a crucial role in enhancing NK-cell immunesurveillance; (b) the host immune system alone is not fully effective against progression of tumor cells;(c) the development of immunoresistance by tumor cells is inevitable in tumor immune surveillance. Ourmodel also supports the importance of infiltrating NK cells in tumor immune surveillance, which can beenhanced by NK cell-based immunotherapeutic approaches.
Format
SBML (L2V4)
Related Publication
  • Mathematical model of tumor-immune surveillance.
  • Mahasa KJ, Ouifki R, Eladdadi A, Pillis L
  • Journal of theoretical biology , 9/ 2016 , Volume 404 , pages: 312-330 , PubMed ID: 27317864
  • DST/NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), University of Stellenbosch, Stellenbosch, South Africa. Electronic address: mahasa@aims.ac.za.
  • We present a novel mathematical model involving various immune cell populations and tumor cell populations. The model describes how tumor cells evolve and survive the brief encounter with the immune system mediated by natural killer (NK) cells and the activated CD8(+) cytotoxic T lymphocytes (CTLs). The model is composed of ordinary differential equations describing the interactions between these important immune lymphocytes and various tumor cell populations. Based on up-to-date knowledge of immune evasion and rational considerations, the model is designed to illustrate how tumors evade both arms of host immunity (i.e. innate and adaptive immunity). The model predicts that (a) an influx of an external source of NK cells might play a crucial role in enhancing NK-cell immune surveillance; (b) the host immune system alone is not fully effective against progression of tumor cells; (c) the development of immunoresistance by tumor cells is inevitable in tumor immune surveillance. Our model also supports the importance of infiltrating NK cells in tumor immune surveillance, which can be enhanced by NK cell-based immunotherapeutic approaches.
Contributors
Ahmad Zyoud

Metadata information

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Taxonomy Homo sapiens
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Curation status
Non-curated


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Model files

Mahasa2016.xml SBML L2V4 file Mahasa2016-tumor–immune surveillance_ Orignal_ Annotated 56.84 KB Preview | Download

Additional files

Mahasa2016.cps COPASI version 4.27 (Build 217) Mahasa2016-tumor–immune surveillance_ Annotated 101.86 KB Preview | Download

  • Model originally submitted by : Ahmad Zyoud
  • Submitted: 04-Mar-2020 12:34:20
  • Last Modified: 04-Mar-2020 12:34:20
Revisions
  • Version: 1 public model Download this version
    • Submitted on: 04-Mar-2020 12:34:20
    • Submitted by: Ahmad Zyoud
    • With comment: Import of Mahasa2016-tumor–immune surveillance
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