McLean1991 Behaviour of HIV in the presence of zidovudine

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  • Population dynamics of HIV within an individual after treatment with zidovudine.
  • McLean AR, Emery VC, Webster A, Griffiths PD
  • AIDS (London, England) , 5/ 1991 , Volume 5 , Issue 5 , pages: 485-489 , PubMed ID: 1677807
  • Laboratory of Mathematical Biology, National Institute for Medical Research, Mill Hill, UK.
  • A new mechanism is proposed for the apparent breakthrough of HIV that occurs approximately 6 months after the commencement of therapy with zidovudine (AZT). Using a simple mathematical model of the interacting population dynamics of HIV and its major host cell in the circulation (the CD4+ lymphocyte), predicted patterns of HIV plasma viraemia in the weeks following treatment with zidovudine are generated. These are in close agreement with observed patterns despite the fact that the model contains no mechanisms for the development of drug-resistant strains of virus. It is suggested that the patterns of viral abundance observed during the first 6 months after treatment may be the result of non-linearities in the interactions between HIV and CD4+ cells, and that it is only after the first post-treatment burst of viral production that drug resistance plays an important role.
Sathvik Anantakrishnan

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McLean1991_HIV.xml SBML Level 3 Version 1 model file 101.68 KB Preview | Download

Additional files

Virus and Latent.png Reproduced the plots for infected cells and the free virus from Fig. 2 of the paper 13.84 KB Preview | Download
McLean1991_HIV.cps Copasi file 100.42 KB Preview | Download
Uninfected.png Reproduced the plot for uninfected CD4+ cells from Fig. 2 of the paper 12.54 KB Preview | Download

  • Model originally submitted by : Sathvik Anantakrishnan
  • Submitted: 05-Dec-2019 11:31:55
  • Last Modified: 05-Dec-2019 11:31:55
  • Version: 1 public model Download this version
    • Submitted on: 05-Dec-2019 11:31:55
    • Submitted by: Sathvik Anantakrishnan
    • With comment: Import of McLean1991 Behaviour of HIV in the presence of zidovudine
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