Uhlén2017 - TCGA-4E-A92E-01A - Uterine Corpus Endometrial Carcinoma (female, 55 years)

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This is a whole genome metabolism model of a female patient diagnosed at the age of 55 years with Uterine Corpus Endometrial Carcinoma affecting the patient's endometrium.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-4E-A92E-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110783.

Other models with the same disease include MODEL1707111003 MODEL1707111585 MODEL1707111586 MODEL1707111587 MODEL1707111588 MODEL1707111589 MODEL1707111590 MODEL1707111591 MODEL1707111592 MODEL1707111593 MODEL1707111594 MODEL1707111595 MODEL1707111596 MODEL1707111597 MODEL1707111598 MODEL1707111599 MODEL1707111600 MODEL1707111601 MODEL1707111602 MODEL1707111603 MODEL1707111604 MODEL1707111605 MODEL1707111606 MODEL1707111607 MODEL1707111608 MODEL1707111609 MODEL1707111610 MODEL1707111611 MODEL1707111612 MODEL1707111613 MODEL1707111614 MODEL1707111615 MODEL1707111616 MODEL1707111617 MODEL1707111618 MODEL1707111619 MODEL1707111620 MODEL1707112033 MODEL1707112034 MODEL1707112035 MODEL1707112036 MODEL1707112037 MODEL1707112038 MODEL1707112039 MODEL1707112040 MODEL1707112041 MODEL1707112042 MODEL1707112043 MODEL1707112044 MODEL1707112045 MODEL1707112046 MODEL1707112047 MODEL1707112048 MODEL1707112049 MODEL1707112050 MODEL1707112051 MODEL1707112052 MODEL1707112053 MODEL1707112054 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To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Related Publication
  • A pathology atlas of the human cancer transcriptome.
  • Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , PubMed ID: 28818916
  • School of Biotechnology, AlbaNova University Center, KTH-Royal Institute of Technology, Stockholm, Sweden.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Adil Mardinoglu

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Model files

MODEL1707110783.xml Patient derived genome scale metabolic model for Uterine Corpus Endometrial Carcinoma 11.12 MB Preview | Download

Additional files

Uterine Corpus Endometrial Carcinoma.zip All 'Uterine Corpus Endometrial Carcinoma' models 113.23 MB Preview | Download

  • Model originally submitted by : Adil Mardinoglu
  • Submitted: Aug 17, 2017 5:14:57 PM
  • Last Modified: Jan 7, 2020 6:02:45 PM
  • Version: 3 public model Download this version
    • Submitted on: Jan 7, 2020 6:02:45 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Import of 'Uhlén2017 - TCGA-4E-A92E-01A - Uterine Corpus Endometrial Carcinoma (female, 55 years)'.
  • Version: 2 public model Download this version
    • Submitted on: Aug 17, 2017 5:14:49 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Current version of Uhlén2017 - TCGA-4E-A92E-01A - Uterine Corpus Endometrial Carcinoma (female, 55 years)
  • Version: 1 public model Download this version
    • Submitted on: Aug 17, 2017 5:14:57 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Original import of MODEL1707110783.xml.origin

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.

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