Uhlén2017 - TCGA-3C-AAAU-01A - Breast Invasive Carcinoma (female, 56 years)

  public model
Model Identifier
MODEL1707110684
Short description

This is a whole genome metabolism model of a female patient diagnosed at the age of 56 years with Breast Invasive Carcinoma affecting the patient's breast.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-3C-AAAU-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110684.

Other models with the same disease include MODEL1707110685 MODEL1707110686 MODEL1707110784 MODEL1707110976 MODEL1707110977 MODEL1707111413 MODEL1707111414 MODEL1707111415 MODEL1707111416 MODEL1707111417 MODEL1707111418 MODEL1707111419 MODEL1707111420 MODEL1707111421 MODEL1707111422 MODEL1707111423 MODEL1707111424 MODEL1707111425 MODEL1707111426 MODEL1707111427 MODEL1707111428 MODEL1707111429 MODEL1707111430 MODEL1707111431 MODEL1707111432 MODEL1707111433 MODEL1707111434 MODEL1707111435 MODEL1707111436 MODEL1707111437 MODEL1707111438 MODEL1707111439 MODEL1707111440 MODEL1707111441 MODEL1707111442 MODEL1707111443 MODEL1707111444 MODEL1707111445 MODEL1707111446 MODEL1707111447 MODEL1707111448 MODEL1707111449 MODEL1707111450 MODEL1707111451 MODEL1707111452 MODEL1707111453 MODEL1707111454 MODEL1707111455 MODEL1707111456 MODEL1707111457 MODEL1707111458 MODEL1707111459 MODEL1707111460 MODEL1707111461 MODEL1707111462 MODEL1707111463 MODEL1707111464 MODEL1707111465 MODEL1707111466 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To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V3)
Related Publication
  • A pathology atlas of the human cancer transcriptome.
  • Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , PubMed ID: 28818916
  • School of Biotechnology, AlbaNova University Center, KTH-Royal Institute of Technology, Stockholm, Sweden.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Contributors
Adil Mardinoglu

Metadata information


Curation status
Non-curated

Name Description Size Actions

Model files

MODEL1707110684.xml Patient derived genome scale metabolic model for Breast Invasive Carcinoma 11.01 MB Preview | Download

Additional files

Breast Invasive Carcinoma.zip All 'Breast Invasive Carcinoma' models 236.34 MB Preview | Download

  • Model originally submitted by : Adil Mardinoglu
  • Submitted: 17-Aug-2017 17:12:32
  • Last Modified: 07-Jan-2020 17:45:34
Revisions
  • Version: 3 public model Download this version
    • Submitted on: 07-Jan-2020 17:45:34
    • Submitted by: Adil Mardinoglu
    • With comment: Import of 'Uhlén2017 - TCGA-3C-AAAU-01A - Breast Invasive Carcinoma (female, 56 years)'.
  • Version: 2 public model Download this version
    • Submitted on: 17-Aug-2017 17:12:21
    • Submitted by: Adil Mardinoglu
    • With comment: Current version of Uhlén2017 - TCGA-3C-AAAU-01A - Breast Invasive Carcinoma (female, 56 years)
  • Version: 1 public model Download this version
    • Submitted on: 17-Aug-2017 17:12:32
    • Submitted by: Adil Mardinoglu
    • With comment: Original import of MODEL1707110684.xml.origin
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