Uhlén2017 - TCGA-2F-A9KO-01A - Bladder Urothelial Carcinoma (male, 64 years)

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This is a whole genome metabolism model of a male patient diagnosed at the age of 64 years with Bladder Urothelial Carcinoma affecting the patient's urinary bladder.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-2F-A9KO-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110440.

Other models with the same disease include MODEL1707110441 MODEL1707110442 MODEL1707110443 MODEL1707110444 MODEL1707110793 MODEL1707110794 MODEL1707110795 MODEL1707110796 MODEL1707110797 MODEL1707110798 MODEL1707110799 MODEL1707110800 MODEL1707110801 MODEL1707110802 MODEL1707110803 MODEL1707110804 MODEL1707110805 MODEL1707110806 MODEL1707110981 MODEL1707110982 MODEL1707112917 MODEL1707112918 MODEL1707112919 MODEL1707112920 MODEL1707112921 MODEL1707113198 MODEL1707113199 MODEL1707113200 MODEL1707113201 MODEL1707113202 MODEL1707113203 MODEL1707113204 MODEL1707113205 MODEL1707113206 MODEL1707113207 MODEL1707113208 MODEL1707113209 MODEL1707113210 MODEL1707113211 MODEL1707113212 MODEL1707113213 MODEL1707113214 MODEL1707113215 MODEL1707113216 MODEL1707113218 MODEL1707113219 MODEL1707113220 MODEL1707113382 MODEL1707113383 MODEL1707113384 MODEL1707113385 MODEL1707113386 MODEL1707113387 MODEL1707113388 MODEL1707113389 MODEL1707113390 MODEL1707113391 MODEL1707113392 MODEL1707113393 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MODEL1707115272 MODEL1707115273 MODEL1707115274 MODEL1707115390 MODEL1707115391 MODEL1707115392 MODEL1707115393 MODEL1707115394 MODEL1707115395 MODEL1707115396 MODEL1707115397 MODEL1707115398 MODEL1707115399 MODEL1707115400 MODEL1707115401 MODEL1707115402 MODEL1707115403 MODEL1707115404 MODEL1707115442 MODEL1707115443 MODEL1707115444 MODEL1707115445 MODEL1707115446 MODEL1707115447 MODEL1707115448 MODEL1707115449 MODEL1707115450 MODEL1707115451 MODEL1707115452 MODEL1707115453 MODEL1707115454 MODEL1707115455 MODEL1707115456 MODEL1707115457 MODEL1707115458 MODEL1707115459 MODEL1707115466 MODEL1707115467 MODEL1707115572 MODEL1707115573 MODEL1707115574 MODEL1707115575 MODEL1707115781 MODEL1707115782 MODEL1707115783 MODEL1707115784 MODEL1707115785 MODEL1707115786 MODEL1707115787 MODEL1707115788 MODEL1707115789 MODEL1707115790 MODEL1707115791 MODEL1707115911 MODEL1707115912 MODEL1707115913 MODEL1707115914 MODEL1707115915 MODEL1707115985 MODEL1707116043 MODEL1707116153 MODEL1707116154 MODEL1707116197 MODEL1707116244 MODEL1707116245 MODEL1707116278 MODEL1707116279 MODEL1707116320 MODEL1707116321 MODEL1707116322 MODEL1707116323 MODEL1707116324 MODEL1707116325 MODEL1707116326 MODEL1707116327 MODEL1707116328 MODEL1707116329 MODEL1707116330 MODEL1707116331 MODEL1707116332 MODEL1707116333 MODEL1707116547 MODEL1707116548 MODEL1707116549 MODEL1707116550 MODEL1707116551 MODEL1707116552 MODEL1707116553 MODEL1707116554 MODEL1707116555 MODEL1707116556 MODEL1707116557 MODEL1707116558 MODEL1707116559 MODEL1707116560 MODEL1707116561 MODEL1707116562 MODEL1707116563 MODEL1707116564 MODEL1707116565 MODEL1707116566 MODEL1707116567 MODEL1707116568 MODEL1707116569 MODEL1707116570 MODEL1707116571 MODEL1707116572 MODEL1707116573 MODEL1707116574 MODEL1707116575 MODEL1707116576 MODEL1707116577 MODEL1707116578 MODEL1707116579 MODEL1707116580 MODEL1707116581 MODEL1707116582 MODEL1707116583 MODEL1707116584 MODEL1707116585 MODEL1707116586 MODEL1707116587 MODEL1707116633 MODEL1707116634 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To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Related Publication
  • A pathology atlas of the human cancer transcriptome.
  • Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , PubMed ID: 28818916
  • School of Biotechnology, AlbaNova University Center, KTH-Royal Institute of Technology, Stockholm, Sweden.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Adil Mardinoglu

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Model files

MODEL1707110440.xml Patient derived genome scale metabolic model for Bladder Urothelial Carcinoma 11.57 MB Preview | Download

Additional files

Bladder Urothelial Carcinoma.zip All 'Bladder Urothelial Carcinoma' models 86.00 MB Preview | Download

  • Model originally submitted by : Adil Mardinoglu
  • Submitted: Aug 17, 2017 5:05:46 PM
  • Last Modified: Jan 7, 2020 5:32:36 PM
  • Version: 3 public model Download this version
    • Submitted on: Jan 7, 2020 5:32:36 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Import of 'Uhlén2017 - TCGA-2F-A9KO-01A - Bladder Urothelial Carcinoma (male, 64 years)'.
  • Version: 2 public model Download this version
    • Submitted on: Aug 17, 2017 5:05:36 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Current version of Uhlén2017 - TCGA-2F-A9KO-01A - Bladder Urothelial Carcinoma (male, 64 years)
  • Version: 1 public model Download this version
    • Submitted on: Aug 17, 2017 5:05:46 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Original import of MODEL1707110440.xml.origin

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.

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