Uhlén2017 - TCGA-2F-A9KO-01A - Bladder Urothelial Carcinoma (male, 64 years)

  public model
Model Identifier
MODEL1707110440
Short description

This is a whole genome metabolism model of a male patient diagnosed at the age of 64 years with Bladder Urothelial Carcinoma affecting the patient's urinary bladder.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-2F-A9KO-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110440.

Other models with the same disease include MODEL1707110441 MODEL1707110442 MODEL1707110443 MODEL1707110444 MODEL1707110793 MODEL1707110794 MODEL1707110795 MODEL1707110796 MODEL1707110797 MODEL1707110798 MODEL1707110799 MODEL1707110800 MODEL1707110801 MODEL1707110802 MODEL1707110803 MODEL1707110804 MODEL1707110805 MODEL1707110806 MODEL1707110981 MODEL1707110982 MODEL1707112917 MODEL1707112918 MODEL1707112919 MODEL1707112920 MODEL1707112921 MODEL1707113198 MODEL1707113199 MODEL1707113200 MODEL1707113201 MODEL1707113202 MODEL1707113203 MODEL1707113204 MODEL1707113205 MODEL1707113206 MODEL1707113207 MODEL1707113208 MODEL1707113209 MODEL1707113210 MODEL1707113211 MODEL1707113212 MODEL1707113213 MODEL1707113214 MODEL1707113215 MODEL1707113216 MODEL1707113218 MODEL1707113219 MODEL1707113220 MODEL1707113382 MODEL1707113383 MODEL1707113384 MODEL1707113385 MODEL1707113386 MODEL1707113387 MODEL1707113388 MODEL1707113389 MODEL1707113390 MODEL1707113391 MODEL1707113392 MODEL1707113393 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To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V3)
Related Publication
  • A pathology atlas of the human cancer transcriptome.
  • Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , PubMed ID: 28818916
  • School of Biotechnology, AlbaNova University Center, KTH-Royal Institute of Technology, Stockholm, Sweden.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Contributors
Adil Mardinoglu

Metadata information


Curation status
Non-curated

Name Description Size Actions

Model files

MODEL1707110440.xml Patient derived genome scale metabolic model for Bladder Urothelial Carcinoma 11.57 MB Preview | Download

Additional files

Bladder Urothelial Carcinoma.zip All 'Bladder Urothelial Carcinoma' models 86.00 MB Preview | Download

  • Model originally submitted by : Adil Mardinoglu
  • Submitted: 17-Aug-2017 17:05:46
  • Last Modified: 07-Jan-2020 17:32:36
Revisions
  • Version: 3 public model Download this version
    • Submitted on: 07-Jan-2020 17:32:36
    • Submitted by: Adil Mardinoglu
    • With comment: Import of 'Uhlén2017 - TCGA-2F-A9KO-01A - Bladder Urothelial Carcinoma (male, 64 years)'.
  • Version: 2 public model Download this version
    • Submitted on: 17-Aug-2017 17:05:36
    • Submitted by: Adil Mardinoglu
    • With comment: Current version of Uhlén2017 - TCGA-2F-A9KO-01A - Bladder Urothelial Carcinoma (male, 64 years)
  • Version: 1 public model Download this version
    • Submitted on: 17-Aug-2017 17:05:46
    • Submitted by: Adil Mardinoglu
    • With comment: Original import of MODEL1707110440.xml.origin
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