Uhlén2017 - TCGA-05-4249-01A - Lung Adenocarcinoma (male, 68 years)

  public model
Model Identifier
MODEL1707110024
Short description

This is a whole genome metabolism model of a male patient diagnosed at the age of 68 years with Lung Adenocarcinoma affecting the patient's lung.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-05-4249-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110024.

Other models with the same disease include MODEL1707110025 MODEL1707110026 MODEL1707110027 MODEL1707110028 MODEL1707110029 MODEL1707110030 MODEL1707110031 MODEL1707110032 MODEL1707110033 MODEL1707110034 MODEL1707110035 MODEL1707110036 MODEL1707110037 MODEL1707110038 MODEL1707110039 MODEL1707110040 MODEL1707110041 MODEL1707110042 MODEL1707110043 MODEL1707110044 MODEL1707110045 MODEL1707110046 MODEL1707110047 MODEL1707110048 MODEL1707110049 MODEL1707110050 MODEL1707110051 MODEL1707110622 MODEL1707110623 MODEL1707110624 MODEL1707110644 MODEL1707110645 MODEL1707110646 MODEL1707110647 MODEL1707110648 MODEL1707110649 MODEL1707110650 MODEL1707110651 MODEL1707110652 MODEL1707110715 MODEL1707110716 MODEL1707110717 MODEL1707110718 MODEL1707110719 MODEL1707110720 MODEL1707110721 MODEL1707110722 MODEL1707110723 MODEL1707110724 MODEL1707110725 MODEL1707110726 MODEL1707110727 MODEL1707110728 MODEL1707110729 MODEL1707110730 MODEL1707110731 MODEL1707110732 MODEL1707110733 MODEL1707110734 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To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V3)
Related Publication
  • A pathology atlas of the human cancer transcriptome.
  • Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , PubMed ID: 28818916
  • School of Biotechnology, AlbaNova University Center, KTH-Royal Institute of Technology, Stockholm, Sweden.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Contributors
Adil Mardinoglu

Metadata information


Curation status
Non-curated

Name Description Size Actions

Model files

MODEL1707110024.xml Patient derived genome scale metabolic model for Lung Adenocarcinoma 10.99 MB Preview | Download

Additional files

Lung Adenocarcinoma.zip All 'Lung Adenocarcinoma' models 112.56 MB Preview | Download

  • Model originally submitted by : Adil Mardinoglu
  • Submitted: 17-Aug-2017 16:54:26
  • Last Modified: 07-Jan-2020 17:42:37
Revisions
  • Version: 3 public model Download this version
    • Submitted on: 07-Jan-2020 17:42:37
    • Submitted by: Adil Mardinoglu
    • With comment: Import of 'Uhlén2017 - TCGA-05-4249-01A - Lung Adenocarcinoma (male, 68 years)'.
  • Version: 2 public model Download this version
    • Submitted on: 17-Aug-2017 16:54:13
    • Submitted by: Adil Mardinoglu
    • With comment: Current version of Uhlén2017 - TCGA-05-4249-01A - Lung Adenocarcinoma (male, 68 years)
  • Version: 1 public model Download this version
    • Submitted on: 17-Aug-2017 16:54:26
    • Submitted by: Adil Mardinoglu
    • With comment: Original import of MODEL1707110024.xml.origin
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