McLean1991 - Behaviour of HIV in the presence of zidovudine

  public model
Model Identifier
BIOMD0000000967
Short description
A new mechanism is proposed for the apparent breakthrough of HIV that occurs approximately 6 months after the commencement of therapy with zidovudine (AZT). Using a simple mathematical model of the interacting population dynamics of HIV and its major host cell in the circulation (the CD4+ lymphocyte), predicted patterns of HIV plasma viraemia in the weeks following treatment with zidovudine are generated. These are in close agreement with observed patterns despite the fact that the model contains no mechanisms for the development of drug-resistant strains of virus. It is suggested that the patterns of viral abundance observed during the first 6 months after treatment may be the result of non-linearities in the interactions between HIV and CD4+ cells, and that it is only after the first post-treatment burst of viral production that drug resistance plays an important role.
Format
SBML (L3V1)
Related Publication
  • Population dynamics of HIV within an individual after treatment with zidovudine.
  • McLean AR, Emery VC, Webster A, Griffiths PD
  • AIDS (London, England) , 5/ 1991 , Volume 5 , Issue 5 , pages: 485-489 , PubMed ID: 1677807
  • Laboratory of Mathematical Biology, National Institute for Medical Research, Mill Hill, UK.
  • A new mechanism is proposed for the apparent breakthrough of HIV that occurs approximately 6 months after the commencement of therapy with zidovudine (AZT). Using a simple mathematical model of the interacting population dynamics of HIV and its major host cell in the circulation (the CD4+ lymphocyte), predicted patterns of HIV plasma viraemia in the weeks following treatment with zidovudine are generated. These are in close agreement with observed patterns despite the fact that the model contains no mechanisms for the development of drug-resistant strains of virus. It is suggested that the patterns of viral abundance observed during the first 6 months after treatment may be the result of non-linearities in the interactions between HIV and CD4+ cells, and that it is only after the first post-treatment burst of viral production that drug resistance plays an important role.
Contributors
Kausthubh Ramachandran, Sathvik Anantakrishnan

Metadata information

hasTaxon
Taxonomy Homo sapiens
12721
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
C3108
C16118
isDescribedBy
occursIn
Brenda Tissue Ontology helper T-lymphocyte

Curation status
Curated


Tags
Name Description Size Actions

Model files

McLean1991.xml SBML Level 3 Version 1 file of HIV behavior in the presence of Zidovudine 96.62 KB Preview | Download

Additional files

McLean1991.cps COPASI 4.29 (Build 228) file of HIV behavior in the presence of Zidovudine 103.44 KB Preview | Download
McLean1991.sedml SED-ML of HIV behavior in the presence of Zidovudine 2.86 KB Preview | Download
McLean1991.omex COMBINE archive of HIV behavior in the presence of Zidovudine 21.12 KB Preview | Download

  • Model originally submitted by : Sathvik Anantakrishnan
  • Submitted: Dec 5, 2019 11:31:55 AM
  • Last Modified: Oct 15, 2020 3:54:04 PM
Revisions
  • Version: 4 public model Download this version
    • Submitted on: Oct 15, 2020 3:54:04 PM
    • Submitted by: Kausthubh Ramachandran
    • With comment: Automatically added model identifier BIOMD0000000967
  • Version: 1 public model Download this version
    • Submitted on: Dec 5, 2019 11:31:55 AM
    • Submitted by: Sathvik Anantakrishnan
    • With comment: Import of McLean1991 Behaviour of HIV in the presence of zidovudine
Legends
: Variable used inside SBML models


Species
No records to display
Reactions
No records to display
Curator's comment:
(added: 15 Oct 2020, 15:53:43, updated: 15 Oct 2020, 15:53:43)
Fig 2 of the model is reproduced here.