Benary2019 - Controlling NFKB dynamics by B-TrCP

  public model
Short description
its a mathematical model studying impact of b_TrCP on NFKB nuclear dynamics. This model is derived from Lipniacki2004 (PMID:15094015).
Format
SBML (L2V4)
Related Publication
  • Controlling Nuclear NF-κB Dynamics by β-TrCP-Insights from a Computational Model.
  • Benary U, Wolf J
  • Biomedicines , 5/ 2019 , Volume 7 , Issue 2
  • Mathematical Modelling of Cellular Processes, Max Delbrück Center for Molecular Medicine, 13125 Berlin-Buch, Germany. uwe.benary@mdc-berlin.de.
  • The canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway regulates central processes in mammalian cells and plays a fundamental role in the regulation of inflammation and immunity. Aberrant regulation of the activation of the transcription factor NF-κB is associated with severe diseases such as inflammatory bowel disease and arthritis. In the canonical pathway, the inhibitor IκB suppresses NF-κB's transcriptional activity. NF-κB becomes active upon the degradation of IκB, a process that is, in turn, regulated by the β-transducin repeat-containing protein (β-TrCP). β-TrCP has therefore been proposed as a promising pharmacological target in the development of novel therapeutic approaches to control NF-κB's activity in diseases. This study explores the extent to which β-TrCP affects the dynamics of nuclear NF-κB using a computational model of canonical NF-κB signaling. The analysis predicts that β-TrCP influences the steady-state concentration of nuclear NF-κB, as well as changes characteristic dynamic properties of nuclear NF-κB, such as fold-change and the duration of its response to pathway stimulation. The results suggest that the modulation of β-TrCP has a high potential to regulate the transcriptional activity of NF-κB.
Contributors
Krishna Kumar Tiwari

Metadata information

hasTaxon
Taxonomy Mus musculus
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
C39173
GO:0034612
isPartOf
occursIn
isDescribedBy

Curation status
Curated


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Model files

Benary2019.xml SBML L2V4 file for benary2019 234.86 KB Preview | Download

Additional files

Benary2019.cps COPASI 4.24 (build 197) file for benary2019 230.93 KB Preview | Download
Benary2019.sedml SEDML file for benary2019 2.41 KB Preview | Download

  • Model originally submitted by : Krishna Kumar Tiwari
  • Submitted: Aug 13, 2019 4:29:35 PM
  • Last Modified: Aug 13, 2019 4:29:35 PM
Revisions
  • Version: 3 public model Download this version
    • Submitted on: Aug 13, 2019 4:29:35 PM
    • Submitted by: Krishna Kumar Tiwari
    • With comment: Automatically added model identifier BIOMD0000000794
Curator's comment:
(added: 13 Aug 2019, 16:29:05, updated: 13 Aug 2019, 16:29:05)
Literature figure 2A,B,C is reproduced. Simulation is done for 630 mins post TNF stimulation on a pre-simulated steady state updated system. Model encoding and simulation is done on COPASI 4.24 (Build 197). Data plotted using Microsoft excel.