Benary2019 - Controlling NFKB dynamics by B-TrCP

  public model
Short description
its a mathematical model studying impact of b_TrCP on NFKB nuclear dynamics. This model is derived from Lipniacki2004 (PMID:15094015).
Related Publication
  • Controlling Nuclear NF-κB Dynamics by β-TrCP-Insights from a Computational Model.
  • Benary U, Wolf J
  • Biomedicines , 5/ 2019 , Volume 7 , Issue 2
  • Mathematical Modelling of Cellular Processes, Max Delbrück Center for Molecular Medicine, 13125 Berlin-Buch, Germany.
  • The canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway regulates central processes in mammalian cells and plays a fundamental role in the regulation of inflammation and immunity. Aberrant regulation of the activation of the transcription factor NF-κB is associated with severe diseases such as inflammatory bowel disease and arthritis. In the canonical pathway, the inhibitor IκB suppresses NF-κB's transcriptional activity. NF-κB becomes active upon the degradation of IκB, a process that is, in turn, regulated by the β-transducin repeat-containing protein (β-TrCP). β-TrCP has therefore been proposed as a promising pharmacological target in the development of novel therapeutic approaches to control NF-κB's activity in diseases. This study explores the extent to which β-TrCP affects the dynamics of nuclear NF-κB using a computational model of canonical NF-κB signaling. The analysis predicts that β-TrCP influences the steady-state concentration of nuclear NF-κB, as well as changes characteristic dynamic properties of nuclear NF-κB, such as fold-change and the duration of its response to pathway stimulation. The results suggest that the modulation of β-TrCP has a high potential to regulate the transcriptional activity of NF-κB.
Krishna Kumar Tiwari

Metadata information

Taxonomy Mus musculus
Mathematical Modelling Ontology Ordinary differential equation model

Curation status

Name Description Size Actions

Model files

Benary2019.xml SBML L2V4 file for benary2019 234.86 KB Preview | Download

Additional files

Benary2019.cps COPASI 4.24 (build 197) file for benary2019 230.93 KB Preview | Download
Benary2019.sedml SEDML file for benary2019 2.41 KB Preview | Download

  • Model originally submitted by : Krishna Kumar Tiwari
  • Submitted: Aug 13, 2019 4:29:35 PM
  • Last Modified: Aug 13, 2019 4:29:35 PM
  • Version: 3 public model Download this version
    • Submitted on: Aug 13, 2019 4:29:35 PM
    • Submitted by: Krishna Kumar Tiwari
    • With comment: Automatically added model identifier BIOMD0000000794
Curator's comment:
(added: 13 Aug 2019, 16:29:05, updated: 13 Aug 2019, 16:29:05)
Literature figure 2A,B,C is reproduced. Simulation is done for 630 mins post TNF stimulation on a pre-simulated steady state updated system. Model encoding and simulation is done on COPASI 4.24 (Build 197). Data plotted using Microsoft excel.