Phan2017 - innate immune in oncolytic virotherapy

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Short description
The paper describes a model on the key components for tumor–immune dynamics in multiple myeloma. Created by COPASI 4.25 (Build 207) This model is described in the article: The Role of the Innate Immune System in Oncolytic Virotherapy Tuan Anh Phan and Jianjun Paul Tian Computational and Mathematical Methods in Medicine (2017) 6587258 Abstract: The complexity of the immune responses is a major challenge in current virotherapy. This study incorporates the innate immune response into our basic model for virotherapy and investigates how the innate immunity affects the outcome of virotherapy. The viral therapeutic dynamics is largely determined by the viral burst size, relative innate immune killing rate, and relative innate immunity decay rate. The innate immunity may complicate virotherapy in the way of creating more equilibria when the viral burst size is not too big, while the dynamics is similar to the system without innate immunity when the viral burst size is big. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
Format
SBML (L3V1)
Related Publication
  • The Role of the Innate Immune System in Oncolytic Virotherapy.
  • Phan TA, Tian JP
  • Computational and mathematical methods in medicine , 1/ 2017 , Volume 2017 , pages: 6587258
  • Department of Mathematical Sciences, New Mexico State University, Las Cruces, NM 88001, USA.
  • The complexity of the immune responses is a major challenge in current virotherapy. This study incorporates the innate immune response into our basic model for virotherapy and investigates how the innate immunity affects the outcome of virotherapy. The viral therapeutic dynamics is largely determined by the viral burst size, relative innate immune killing rate, and relative innate immunity decay rate. The innate immunity may complicate virotherapy in the way of creating more equilibria when the viral burst size is not too big, while the dynamics is similar to the system without innate immunity when the viral burst size is big.
Contributors
Jinghao Men

Metadata information

hasTaxon
Taxonomy Homo sapiens
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
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isVersionOf

Curation status
Curated


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Model files

Phan2017.xml SBML L3V1 representation of oncolytic virotherapy model 62.05 KB Preview | Download

Additional files

Phan2017.cps CPS file of the model in COPASI 74.60 KB Preview | Download
Phan2017.sedml Auto-generated SEDML file 1.09 KB Preview | Download
Fig.2'.png Fig.2 immune cell count generated in the main model 22.57 KB Preview | Download

  • Model originally submitted by : Jinghao Men
  • Submitted: 11-Jul-2019 09:42:29
  • Last Modified: 11-Jul-2019 09:42:29
Revisions
  • Version: 3 public model Download this version
    • Submitted on: 11-Jul-2019 09:42:29
    • Submitted by: Jinghao Men
    • With comment: Automatically added model identifier BIOMD0000000748
Curator's comment:
(added: 11 Jul 2019, 09:42:05, updated: 11 Jul 2019, 09:42:05)
Publication figure 2 reproduced as per literature. Other figures are reproduced with different sets of parameters. Figure data is generated using COPASI 4.25 (build 197).