Mouse Iron Distribution - Adequate iron diet (tracer)

  public model
Short description

Mouse Iron Distribution Dynamics

Dynamic model of iron distribution in mice. This model includes normal iron and radioactive labelled tracer iron species and was used for parameter estimation given the data from Lopes et al. 2010 for mice fed an adequate iron diet.


Format
SBML (L2V4)
Related Publication
  • Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient.
  • Pedro Mendes
  • BMC systems biology , 5/ 2017 , Volume 11 , Issue 1 , pages: 57
  • Center for Quantitative Medicine and Department of Cell Biology, UConn Health, Farmington, CT, 06030, USA.
  • Iron is an essential element of most living organisms but is a dangerous substance when poorly liganded in solution. The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents. Disruption of iron regulation in mammals leads to disorders such as anemia and hemochromatosis, and contributes to the etiology of several other diseases such as cancer and neurodegenerative diseases. Here we test the hypothesis that hepcidin alone is able to regulate iron distribution in different dietary regimes in the mouse using a computational model of iron distribution calibrated with radioiron tracer data.A model was developed and calibrated to the data from adequate iron diet, which was able to simulate the iron distribution under a low iron diet. However simulation of high iron diet shows considerable deviations from the experimental data. Namely the model predicts more iron in red blood cells and less iron in the liver than what was observed in experiments.These results suggest that hepcidin alone is not sufficient to regulate iron homeostasis in high iron conditions and that other factors are important. The model was able to simulate anemia when hepcidin was increased but was unable to simulate hemochromatosis when hepcidin was suppressed, suggesting that in high iron conditions additional regulatory interactions are important.
Contributors
Krishna Kumar Tiwari, Pedro Mendes

Metadata information

hasTaxon
Taxonomy Mus musculus
is
Gene Ontology iron ion homeostasis
BioModels Database MODEL1605030002
BIOMD0000000735
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
isDescribedBy
Curation status
Curated
Name Description Size Actions

Model files

Parmar2017_Adequate_tracer.xml SBML L2V4 representation of Parmar2017 - Mouse Iron Distribution - Adequate iron diet (tracer) 195.21 KB Preview | Download

Additional files

MODEL1605030002.png Auto-generated Reaction graph (PNG) 683.78 KB Preview | Download
MODEL1605030002.svg Auto-generated Reaction graph (SVG) 107.19 KB Preview | Download
MODEL1605030002-biopax2.owl Auto-generated BioPAX (Level 2) 65.83 KB Preview | Download
Parmar2017_Adequate_tracer.cps COPASI 4.24 (build196) file depicting literature figure 2 261.65 KB Preview | Download
MODEL1605030002.m Auto-generated Octave file 24.48 KB Preview | Download
Parmar2017_Adequate_tracer.sedml SEDML file 1.15 KB Preview | Download
MODEL1605030002.xpp Auto-generated XPP file 17.63 KB Preview | Download
MODEL1605030002.vcml Auto-generated VCML file 897.00 bytes Preview | Download
MODEL1605030002.sci Auto-generated Scilab file 67.00 bytes Preview | Download
MODEL1605030002-biopax3.owl Auto-generated BioPAX (Level 3) 115.00 KB Preview | Download
MODEL1605030002_urn.xml Auto-generated SBML file with URNs 177.90 KB Preview | Download

  • Model originally submitted by : Pedro Mendes
  • Submitted: May 3, 2016 8:41:26 PM
  • Last Modified: Mar 4, 2019 4:44:47 PM
Revisions
  • Version: 4 public model Download this version
    • Submitted on: Mar 4, 2019 4:44:47 PM
    • Submitted by: Krishna Kumar Tiwari
    • With comment: Automatically added model identifier BIOMD0000000735
  • Version: 2 public model Download this version
    • Submitted on: May 19, 2017 4:23:10 PM
    • Submitted by: Pedro Mendes
    • With comment: Current version of Parmar2017 - Mouse Iron Distribution - Adequate iron diet (tracer)
  • Version: 1 public model Download this version
    • Submitted on: May 3, 2016 8:41:26 PM
    • Submitted by: Pedro Mendes
    • With comment: Original import of Mouse Iron Distribution - Adequate iron diet (tracer)
Curator's comment:
(added: 04 Mar 2019, 15:58:06, updated: 04 Mar 2019, 15:58:06)
Reproduced Figure: Figure 2 of Literature. Simulation Condition: Simulation in COPASI need to be done as Tasks --> parameter Estimation --> Run (Method: Current Solution Statistics). Mode is reproduced and simulated in COPASI 4.24 (build 196) and figures are generated using Libreoffice calc.