Araujo2016 - Positive feedback in Cdk1 signalling keeps mitotic duration short and constant

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Araujo2016 - Positive feedback in Cdk1 signalling keeps mitotic duration short and constant

This model is described in the article:

Araujo AR, Gelens L, Sheriff RS, Santos SD.
Mol. Cell 2016 Oct; 64(2): 362-375

Abstract:

Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is short and remarkably constant. Surprisingly, there is no correlation between cell-cycle length and mitotic duration, suggesting that mitosis is temporally insulated from variability in earlier cell-cycle phases. By combining live cell imaging and computational modeling, we showed that positive feedback is the molecular mechanism underlying the temporal insulation of mitosis. Perturbing positive feedback gave rise to a sluggish, variable entry and progression through mitosis and uncoupled duration of mitosis from variability in cell cycle length. We show that positive feedback is important to keep mitosis short, constant, and temporally insulated and anticipate it might be a commonly used regulatory strategy to create modularity in other biological systems.

This model is hosted on BioModels Database and identified by: BIOMD0000000657.

To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8.

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Format
SBML (L2V4)
Related Publication
  • Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events.
  • Araujo AR, Gelens L, Sheriff RS, Santos SD
  • Molecular cell , 10/ 2016 , Volume 64 , Issue 2 , pages: 362-375
  • Quantitative Cell Biology Lab, MRC-Clinical Sciences Centre (CSC), London W12 0NN, UK; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.
  • Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is short and remarkably constant. Surprisingly, there is no correlation between cell-cycle length and mitotic duration, suggesting that mitosis is temporally insulated from variability in earlier cell-cycle phases. By combining live cell imaging and computational modeling, we showed that positive feedback is the molecular mechanism underlying the temporal insulation of mitosis. Perturbing positive feedback gave rise to a sluggish, variable entry and progression through mitosis and uncoupled duration of mitosis from variability in cell cycle length. We show that positive feedback is important to keep mitosis short, constant, and temporally insulated and anticipate it might be a commonly used regulatory strategy to create modularity in other biological systems.
Contributors
Rahuman Sheriff

Metadata information

is
BioModels Database MODEL1710040001
BioModels Database BIOMD0000000657
hasTaxon
Taxonomy Homo sapiens
isDescribedBy
Mathematical Modelling Ontology Ordinary differential equation model
PubMed 27768873
PubMed 27768873
hasPart
Pathway Ontology M phase pathway
hasProperty
Curation status
Curated
  • Model originally submitted by : Rahuman Sheriff
  • Submitted: 04-Oct-2017 14:17:35
  • Last Modified: 04-Oct-2017 15:41:20
Revisions
  • Version: 3 public model Download this version
    • Submitted on: 04-Oct-2017 15:41:20
    • Submitted by: Rahuman Sheriff
    • With comment: Notes updated using online editor.
  • Version: 2 public model Download this version
    • Submitted on: 06-Oct-2017 10:21:07
    • Submitted by: Rahuman Sheriff
    • With comment: Current version of Araujo2016 - Positive feedback in Cdk1 signalling keeps mitotic duration short and constant
  • Version: 1 public model Download this version
    • Submitted on: 04-Oct-2017 14:17:35
    • Submitted by: Rahuman Sheriff
    • With comment: Original import of New Model
Curator's comment:
(added: 04 Oct 2017, 15:26:41, updated: 04 Oct 2017, 15:26:41)
Figure 7B of the reference publication has been reproduced. Simulations of the model were performed in COPASI 4.19 (Build 140). Figures are plotted using MatLab R2014b.