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BIOMD0000000156 - Zatorsky2006_p53_Model5


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Reference Publication
Publication ID: 16773083
Geva-Zatorsky N, Rosenfeld N, Itzkovitz S, Milo R, Sigal A, Dekel E, Yarnitzky T, Liron Y, Polak P, Lahav G, Alon U.
Oscillations and variability in the p53 system.
Mol. Syst. Biol. 2006; 2: 2006.0033
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.  [more]
Original Model: BIOMD0000000156.origin
Submitter: Harish Dharuri
Submission ID: MODEL0076384106
Submission Date: 14 Jan 2008 21:33:20 UTC
Last Modification Date: 20 Mar 2014 16:28:50 UTC
Creation Date: 10 Jan 2008 17:38:04 UTC
Encoders:  Harish Dharuri
   Vijayalakshmi Chelliah
set #1
bqmodel:isDerivedFrom PubMed 15725723
set #2
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
set #3
bqbiol:isPartOf KEGG Pathway p53 signaling pathway - Homo sapiens (human)
Gene Ontology DNA damage response, signal transduction by p53 class mediator
set #4
bqbiol:hasTaxon Taxonomy Homo sapiens
set #5
bqbiol:occursIn Brenda Tissue Ontology MCF-7 cell

The model reproduces time profile of p53 and Mdm2 as depicted in Fig 6B of the paper for Model 5. Results obtained using MathSBML.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Publication ID: 16773083 Submission Date: 14 Jan 2008 21:33:20 UTC Last Modification Date: 20 Mar 2014 16:28:50 UTC Creation Date: 10 Jan 2008 17:38:04 UTC
Mathematical expressions
p53 production Mdm2 dependent p53 degradation p53 dependent Mdm2 precursor production Mdm2 synthesis from precursor
Mdm2 degradation      
Physical entities
Compartments Species
cell p53 Mdm2 precursor Mdm2
Global parameters
psi alpha_x alpha_xy beta_y
alpha_y alpha_0 Theta  
Reactions (5)
 p53 production  → [p53];  
 Mdm2 dependent p53 degradation [p53] → ;   {Mdm2}
 p53 dependent Mdm2 precursor production  → [precursor Mdm2];   {p53}
 Mdm2 synthesis from precursor [precursor Mdm2] → [Mdm2];  
 Mdm2 degradation [Mdm2] ↔ ;  
 cell Spatial dimensions: 3.0  Compartment size: 1.0
Compartment: cell
Initial concentration: 0.02
Compartment: cell
Initial concentration: 0.2
   precursor Mdm2
Compartment: cell
Initial concentration: 0.5
Global Parameters (7)
Value: 1.0
Value: 3.7
Value: 1.5
Value: 0.9
Value: 1.1
Value: 2.0
Representative curation result(s)
Representative curation result(s) of BIOMD0000000156

Curator's comment: (updated: 11 Jan 2008 22:26:32 GMT)

Plot corresponds to Fig 6B for model 5. Simulation result obtained using MathSBML.