View - Models of the month

Each "Model of the Month" is an article which explores the biological significance of a particular model from BioModels Database. Every article includes elements such as:

• the description of the model itself and its results
• the biological background of the model
• a brief description of the biological processes that are encoded as a mathematical model
• the biological role of each of the model elements
• the diseases that are caused due to the malfunction of these elements
• the presenters own view on the model

Direct access to the models of the month for a given year: 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012

2012

• February: BIOMD0000000328

  Bucher et al. 2011. A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes. - Christine Hoyer

• January: BIOMD0000000401, BIOMD0000000402, BIOMD0000000403

  Ayati et al. (2010). A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease. - Vijayalakshmi Chelliah

2011

• December: BIOMD0000000364

  Lee et al. (2010). A revisit to the one form kinetic model of prothrombinase. - Massimo Lai

• November: BIOMD0000000356

  Nyman et al. (2011). A Hierarchical Whole-body Modeling Approach Elucidates the Link between in Vitro Insulin Signaling and in Vivo Glucose Homeostasis. - Ishan Ajmera

• October: BIOMD0000000271, BIOMD0000000272

  Becker et al. (2010). Covering a broad dynamic range: information processing at the erythropoietin receptor. - Nick Juty

• September: BIOMD0000000069

  Fuss et al. (2006). Bistable switching and excitable behaviour in the activation of Src at mitosis. - Denis Brun

• August: BIOMD0000000239

  Jiang et al. (2007). A kinetics core model of the Glucose-simulated insulin secretion network of pancreatic beta cells. - Ishan Ajmera

• July: BIOMD0000000338, BIOMD0000000339, BIOMD0000000340

  Wajima et al. (2009), A comprehensive model for the humoral coagulation network in human. - Michael Schubert

• June: BIOMD0000000301

  Friedland et al., (2009). Synthetic gene networks that count. - Gael Jalowicki

• May: BIOMD0000000296

  Balagaddé et al., (2008). A synthetic Escherichia coli predator-prey ecosystem. - Michele Mattioni

• April: BIOMD0000000306, BIOMD0000000307, BIOMD0000000308, BIOMD0000000309, BIOMD0000000310, BIOMD0000000311, BIOMD0000000312

  Tyson et al., (2003). Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. - Lukas Endler

• March: BIOMD0000000129, BIOMD0000000130, BIOMD0000000131, BIOMD0000000132, BIOMD0000000133, BIOMD0000000134, BIOMD0000000135, BIOMD0000000136, BIOMD0000000141, BIOMD0000000142

  Izhikevich EM (2004), Which model to use for cortical spiking neurons? - Junmei Zhu

• February: BIOMD0000000270

  Schilling et al. (2009), Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. - Benedetta Frida Baldi

• January: BIOMD0000000215

  Schulz et al., (2009), Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. - Christine Hoyer

2010

• December: BIOMD0000000258

  Ortega et al. (2006), Bistability from double phosphorylation in signal transduction. Kinetic and structural requirements. - Massimo Lai

• November: BIOMD0000000249

  Restif and Grenfell (2006), Integrating life history and cross-immunity into the evolutionary dynamics of pathogens. - Lukas Endler

• August: BIOMD0000000178, BIOMD0000000267

  Lebeda et. al. (2008), Onset dynamics of type A botulinum neurotoxin-induced paralysis. - Vijayalakshmi Chelliah

• July: BIOMD0000000139, BIOMD0000000140

  Hoffmann et. al. (2002), The IkB-NF-kB Signaling Module: Temporal Control and Selective Gene Activation. - Lu Li

• June: BIOMD0000000209, BIOMD0000000210

  Chickarmane and Peterson (2008), A computational model for understanding stem cell, trophectoderm and endoderm lineage determination - Nick Juty

• May: BIOMD0000000127

  Izhikevich EM (2003), Simple model of spiking neurons - Michele Mattioni

• April: BIOMD0000000166

  Zhu et al. (2007), A theoretical study on activation of transcription factor modulated by intracellular Ca2+ oscillations - Benedetta Frida Baldi

• March: BIOMD0000000223

  Borisov et al. (2009), Systems-level interactions between insulin-EGF networks amplify mitogenic signaling - Christine Hoyer

• February: BIOMD0000000228

  Swat et al. (2004), Bifurcation analysis of the regulatory modules of the mammalian G1/S transition - Lukas Endler

• January: BIOMD0000000234

  Tham et al. (2008), A Pharmacodynamic Model for the Time Course of Tumour Shrinkage by Gemcitabine + Carboplatin in Non-Small Cell Lung Cancer Patients - Vijayalakshmi Chelliah

2009

• September: BIOMD0000000200

  Bray and Bourret (1995), Bacterial Chemotaxis - Melanie I. Stefan

• August: BIOMD0000000098, BIOMD0000000224

  Goldbeter et al. (1990), Meyer and Stryer (1991), Two Models of Calcium Spiking - Vijayalakshmi Chelliah

• July: BIOMD0000000184

  Lavrentovich and Hemkin (2008), Calcium Oscillations in Astrocytes - Michele Mattioni

• June: BIOMD0000000018

  Morrison and Allegra (1989), Folate Cycle - Lukas Endler

• May: BIOMD0000000023

  Rohwer and Botha (2001), Sucrose accumulation in sugar cane - Nick Juty

• April: BIOMD0000000201

  Goldbeter and Pourquie (2008), Somite Segmentation Clock - Melanie I. Stefan

• March: BIOMD0000000183

  Stefan et al. (2008), Allosteric Model of Calmodulin - Lu Li

• February: BIOMD0000000188, BIOMD0000000189

  Proctor and Gray (2008), The p53-Mdm2 System - Vijayalakshmi Chelliah

• January: BIOMD0000000152

  Fernandez et al. (2006), Integration of glutamate and dopamine signals - Michele Mattioni

2008

• December: BIOMD0000000105

  Proctor et al. (2007), Ubiquitin-Proteasome System - Ranjita Dutta Roy

• November: BIOMD0000000071

  Bakker et al. (2001), Glycolysis in Trypanosoma - Lukas Endler

• October: BIOMD0000000067

  Fung et al. (2005), Metabolator - Nick Juty

• September: BIOMD0000000101

  Vilar et al. (2006), TGF-β - Noriko Hiroi

• August: BIOMD0000000106

  Yang et al. (2007), Arachidonic Acid - Dominic P. Tolle

• July: BIOMD0000000039

  Marhl et al. (2000), Calcium Oscillations - Lu Li

• June: BIOMD0000000102

  Legewie et al. (2006), Apoptosis - Melanie I. Stefan

• May: BIOMD0000000085

  Maurya et al. (2005), GTPase-Cycle Module - Michele Mattioni

• April: BIOMD0000000003, BIOMD0000000004

  Goldbeter (1991), Minimal Mitotic Oscillator - Anika Oellrich

• March: BIOMD0000000107

  Novak and Tyson (1993), M-phase Control - Michele Mattioni and Judith Zaugg

• February: BIOMD0000000147

  O'Dea et al. (2007), IκB Metabolism - Dominic P. Tolle

• January: BIOMD0000000032

  Kofahl and Klipp (2004), Yeast Pheromone Pathway - Melanie I. Stefan

2007

• December: BIOMD0000000138

  Tabak et al. (2007), Dopamine - Lu Li

• November: BIOMD0000000125

  Komarova et al. (2005), Specificity in Cell Signaling - Dominic P. Tolle

• October: BIOMD0000000148

  Komarova et al. (2003), Bone Remodeling - Anika Oellrich

• September: BIOMD0000000040

  Fields and Noyes (1974), The Oregonator - Christian Knüpfer

• August: BIOMD0000000079

  Goldbeter (2006), Human Weight Cycling - Melanie I. Stefan

• July: BIOMD0000000062

  Bhartiya et al. (2004), Tryptophan Operon - Antonia Mayer

• June: BIOMD0000000026, BIOMD0000000031

  Markevich et al. (2004), MAPK - Lu Li

• May: BIOMD0000000017

  Hoefnagel et al. (2002), Metabolic Control Analysis - Dominic P. Tolle

• April: BIOMD0000000058

  Bindschadler and Sneyd (2001), Coupled Calcium Oscillators - Melanie I. Stefan

• March: BIOMD0000000001

  Edelstein (1996), Nicotinic Receptor - Nicolas Le Novère

• February: BIOMD0000000049

  Sasagawa (2005), MAPK - Lu Li

• January: BIOMD0000000064

  Teusink (2000), Glycolysis - Dominic P. Tolle

2006

• December: BIOMD0000000065

  Yildirim (2003), lac Operon - Melanie I. Stefan

• November: BIOMD0000000025

  Smolen (2002), Circadian Oscillator - Enuo He

• October: BIOMD0000000005

  Tyson (1991), Modelling Cell Division - Nicolas Le Novère

• September: BIOMD0000000020

  Hodgkin and Huxley (1952), Membrane Current in the Giant Squid Axon - Melanie I. Stefan

• August: BIOMD0000000048

  Kholodenko (1999), Epidermal Growth Factor Receptor signalling - Renaud Schiappa

• July: BIOMD0000000012

  Elowitz and Leibler (2000), The Repressilator - Dominic P. Tolle

• June: BIOMD0000000009

  Huang and Ferrell (1996), MAPK ultrasensitivity - Nicolas Le Novère