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BIOMD0000000088 - Maeda2006_MyosinPhosphorylation

 

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Reference Publication
Publication ID: 16923126
Maeda A, Ozaki Y, Sivakumaran S, Akiyama T, Urakubo H, Usami A, Sato M, Kaibuchi K, Kuroda S.
Ca2+ -independent phospholipase A2-dependent sustained Rho-kinase activation exhibits all-or-none response.
Genes Cells 2006 Sep; 11(9): 1071-1083
Undergraduate Program for Bioinformatics and Systems Biology, Graduate School of Information Science and Technology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.  [more]
Model
Original Model: BIOMD0000000088.xml.origin
Submitter: Yu-ichi Ozaki
Submission ID: MODEL7944007619
Submission Date: 28 Jan 2007 23:57:52 UTC
Last Modification Date: 05 Jul 2012 16:29:02 UTC
Creation Date: 30 Sep 2006 17:25:23 UTC
Encoders:  Harish Dharuri
   Hiroshi Kobayashi
set #1
bqbiol:is Gene Ontology actin cytoskeleton organization
Gene Ontology regulation of Rho protein signal transduction
bqbiol:isPartOf KEGG Pathway hsa04810
bqbiol:occursIn Taxonomy Homo sapiens
Notes

The model reproduces Fig 2B, D, F, and 2H. The dynamics correspond to a stimulus of 1 U/ml of thrombin which is equal to 0.01 uM. Phosphorylated MLC is the sum of pMLC (s359) and ppMLC (s360). A slight discrepancy in peak values of species between the figure in the paper and simulation result might be due to different initial conditions in the two sets. The model was successfully tested on MathSBML. It is possible to simulate the model on other software that do not support "Events" at this time by removing the "listOfEvents" and substituting a value of 0.01 for thrombin (s2). This does not change the model very much. With the latter format, the model was also successfully tested on Copasi.


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 16923126 Submission Date: 28 Jan 2007 23:57:52 UTC Last Modification Date: 05 Jul 2012 16:29:02 UTC Creation Date: 30 Sep 2006 17:25:23 UTC
Mathematical expressions
Reactions
A2-1.1 A1-2 A1-5.1 A1-3
A1-4 A1-6 A1-7 A2-2.1
A1-9 B1-1 B2-1.1 B2-2.1
B2-3.1 B2-1.2 B2-3.2 A2-2.2
B1-2 B1-3 B1-4 A2-1.2
A1-1 A1-8 A1-5.2 C1-2
C1-3 C1-4 C1-1 C1-5
C2-1.1 C2-2.1 C2-1.2 C2-2.2
C1-6 C1-7 C1-8 D3-1
D1-2 D1-3 D1-4 D1-6
D1-5 D1-10 D1-9 D1-8
D1-7 E1-1 E1-3 E1-5
E1-4 D2-1.2 D1-1 E1-7
E1-8 E1-9 E1-6 E1-2
D2-1.1 E2-1.1.3 E2-1.1.2 E2-1.1.1
E2-1.2.3 E2-1.2.2 E2-1.2.1 E1-10
E1-11 E1-12 E1-13 F2-1.1
F2-2.1 F2-1.2 F2-2.2 F2-3.1
F2-4.1 F2-3.2 F2-4.2 F2-14.1
F2-14.2 F2-13.1 F2-13.2 F2-11.1
F2-9.1 F2-12.1 F2-10.1 F2-11.2
F2-9.2 F2-12.2 F2-10.2 F1-1
F2-7.1 F2-8.1 F2-7.2 F2-8.2
F2-5.1.1 F2-5.2.1 F2-5.3.1 F2-5.4.1
F2-6.1.1 F2-6.2.1 F2-6.3.1 F2-6.4.1
F2-6.4.2 F2-5.4.2 F2-6.3.2 F2-5.3.2
F2-6.2.2 F2-5.2.2 F2-6.1.2 F2-5.1.2
D3-3 D3-2    
Events
event_0000001      
Physical entities
Compartments Species
Default thrombin thrombin_ligand Ca_super_2_plus__endsuper_ ext
     
cytosol thrombin_R pro_thrombinR thrombinR active
RGS Inositol sa40_degraded
thrombinR RGS GTP
G_sub_q_endsub__alpha_.GTP GDP IP3R
3IP3.IP3R p115RhoGEF Rho-kinase
RhoGAP DAG IP3
Rho_GAP Rho.GTP PIP2
PC Rho.GDP Rho_GEF
Rho_GEF_active Rho.GTP.Rho-kinase Ca_super_2_plus__endsuper_.CaM
2Ca_super_2_plus__endsuper_.CaM 3Ca_super_2_plus__endsuper_.CaM 4Ca_super_2_plus__endsuper_.CaM
MLCK MLCK.Ca_super_2_plus__endsuper_.CaM MLCK.2Ca_super_2_plus__endsuper_.CaM
MLCK.3Ca_super_2_plus__endsuper_.CaM MLCK.4Ca_super_2_plus__endsuper_.CaM PKC
PKC active1 PKC.DAG PKC active_2
PKC active_3 csa39_degraded csa36_degraded
csa35_degraded PKC active_1.CPI PKC active_2.CPI
PKC active_3.CPI CPI-17.MYPT1_PPase CPI-17.MYPT1_PPase
CPI-17 MLC MLC
Rho-kinase.MLC Rho-kinase.MLC CPI-17
Ca_super_2_plus__endsuper_ CaM G_beta__gamma__1
G_beta__gamma__2 PLC_beta_ Ca_super_2_plus__endsuper_ trunsp
Ca_super_2_plus__endsuper_ pump G_sub_12_endsub__alpha__beta__gamma__thrombinR active p115RhoGEF.GTP_alpha_
G_sub_12_endsub__alpha__beta__gamma_ G_sub_12_endsub__alpha_.GDP G_sub_12_endsub__alpha_.GTP
G_sub_q_endsub__alpha_.GDP G_sub_q_endsub__alpha__beta__gamma__thrombinR active G_sub_q_endsub__alpha__beta__gamma_
PLC_beta_.G_sub_q_endsub__alpha_.GTP 2Ca_super_2_plus__endsuper_ .Ca_super_2_plus__endsuper_ trunsp Ca_super_2_plus__endsuper_ pump.Ca_super_2_plus__endsuper_
Rho.GTP.Rho-kinase.MLC Rho.GTP.Rho-kinase.MLC MLC
MYPT1.Rho-kinase MYPT1.MLC MYPT1.MLC
MYPT1.MLC MYPT1.MLC MLCK.MLC
MLCK.MLC MYPT1.Rho-kinase MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC
MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC
MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC MLCK.Ca_super_2_plus__endsuper_.CaM.MLC
MLCK.Ca_super_2_plus__endsuper_.CaM.MLC Ca_super_2_plus__endsuper_ ext leak Ca_super_2_plus__endsuper_ int leak
PLC_beta_.G_sub_q_endsub__alpha_.GTP.Ca_super_2_plus__endsuper_ PKC.Ca_super_2_plus__endsuper_.DAG PKC.Ca_super_2_plus__endsuper_
PLC_beta_.G_sub_q_endsub_.GTP.Ca.PIP2 PLC_beta_.Ca.PIP2 PLC_beta_.Ca_super_2_plus__endsuper_
MYPT1_PPase MYPT1_PPase  
ER Ca_super_2_plus__endsuper_ store    
Reactions (110)
 
 A2-1.1 [thrombin] + [pro_thrombinR] ↔ [thrombin_R];  
 
 A1-2 [GTP] + [G_sub_12_endsub__alpha__beta__gamma__thrombinR active] → [G_sub_12_endsub__alpha_.GTP] + [G_beta__gamma__1] + [GDP] + [thrombinR];  
 
 A1-5.1 [thrombinR] → [sa40_degraded];  
 
 A1-3 [G_sub_q_endsub__alpha__beta__gamma_] + [thrombinR active] ↔ [G_sub_q_endsub__alpha__beta__gamma__thrombinR active];  
 
 A1-4 [G_sub_q_endsub__alpha__beta__gamma__thrombinR active] + [GTP] → [G_sub_q_endsub__alpha_.GTP] + [thrombinR] + [GDP] + [G_beta__gamma__2];  
 
 A1-6 [G_sub_12_endsub__alpha_.GTP] → [G_sub_12_endsub__alpha_.GDP];  
 
 A1-7 [G_beta__gamma__1] + [G_sub_12_endsub__alpha_.GDP] → [G_sub_12_endsub__alpha__beta__gamma_];  
 
 A2-2.1 [RGS] + [G_sub_q_endsub__alpha_.GTP] ↔ [RGS];  
 
 A1-9 [G_beta__gamma__2] + [G_sub_q_endsub__alpha_.GDP] → [G_sub_q_endsub__alpha__beta__gamma_];  
 
 B1-1 [G_sub_12_endsub__alpha_.GTP] + [p115RhoGEF] ↔ [p115RhoGEF.GTP_alpha_];  
 
 B2-1.1 [Rho.GDP] → [Rho.GTP];   {p115RhoGEF.GTP_alpha_}
 
 B2-2.1 [p115RhoGEF] + [Rho.GDP] ↔ [Rho_GEF];  
 
 B2-3.1 [RhoGAP] + [Rho.GTP] ↔ [Rho_GAP];  
 
 B2-1.2 [Rho_GEF] → [Rho.GTP] + [p115RhoGEF];  
 
 B2-3.2 [Rho_GAP] → [Rho.GDP] + [RhoGAP];  
 
 A2-2.2 [RGS] → [G_sub_q_endsub__alpha_.GDP] + [RGS];  
 
 B1-2 [p115RhoGEF.GTP_alpha_] → [G_sub_12_endsub__alpha_.GDP] + [p115RhoGEF];  
 
 B1-3 [Rho.GTP] → [Rho.GDP];  
 
 B1-4 [Rho-kinase] + [Rho.GTP] ↔ [Rho.GTP.Rho-kinase];  
 
 A2-1.2 [thrombin_R] → [thrombinR active] + [thrombin_ligand] + [thrombin];  
 
 A1-1 [G_sub_12_endsub__alpha__beta__gamma_] + [thrombinR active] ↔ [G_sub_12_endsub__alpha__beta__gamma__thrombinR active];  
 
 A1-8 [G_sub_q_endsub__alpha_.GTP] → [G_sub_q_endsub__alpha_.GDP];  
 
 A1-5.2 [thrombinR active] → [sa40_degraded];  
 
 C1-2 [G_sub_q_endsub__alpha_.GTP] + [PLC_beta_.Ca_super_2_plus__endsuper_] ↔ [PLC_beta_.G_sub_q_endsub__alpha_.GTP.Ca_super_2_plus__endsuper_];  
 
 C1-3 [PLC_beta_] + [G_sub_q_endsub__alpha_.GTP] ↔ [PLC_beta_.G_sub_q_endsub__alpha_.GTP];  
 
 C1-4 [Ca_super_2_plus__endsuper_] + [PLC_beta_.G_sub_q_endsub__alpha_.GTP] ↔ [PLC_beta_.G_sub_q_endsub__alpha_.GTP.Ca_super_2_plus__endsuper_];  
 
 C1-1 [PLC_beta_] + [Ca_super_2_plus__endsuper_] ↔ [PLC_beta_.Ca_super_2_plus__endsuper_];  
 
 C1-5 [PLC_beta_.G_sub_q_endsub__alpha_.GTP.Ca_super_2_plus__endsuper_] → [PLC_beta_.Ca_super_2_plus__endsuper_] + [G_sub_q_endsub__alpha_.GDP];  
 
 C2-1.1 [PLC_beta_.Ca_super_2_plus__endsuper_] + [PIP2] ↔ [PLC_beta_.Ca.PIP2];  
 
 C2-2.1 [PLC_beta_.G_sub_q_endsub__alpha_.GTP.Ca_super_2_plus__endsuper_] + [PIP2] ↔ [PLC_beta_.G_sub_q_endsub_.GTP.Ca.PIP2];  
 
 C2-1.2 [PLC_beta_.Ca.PIP2] → [IP3] + [DAG] + [PLC_beta_.Ca_super_2_plus__endsuper_];  
 
 C2-2.2 [PLC_beta_.G_sub_q_endsub_.GTP.Ca.PIP2] → [DAG] + [IP3] + [PLC_beta_.G_sub_q_endsub__alpha_.GTP.Ca_super_2_plus__endsuper_];  
 
 C1-6 [DAG] → [PC];  
 
 C1-7 [IP3] → [Inositol];  
 
 C1-8 [IP3R] + 3.0 × [IP3] ↔ [3IP3.IP3R];  
 
 D3-1 [Ca_super_2_plus__endsuper_ store] ↔ [Ca_super_2_plus__endsuper_];   {3IP3.IP3R}
 
 D1-2 [2Ca_super_2_plus__endsuper_ .Ca_super_2_plus__endsuper_ trunsp] → 2.0 × [Ca_super_2_plus__endsuper_ store] + [Ca_super_2_plus__endsuper_ trunsp];  
 
 D1-3 [CaM] + [Ca_super_2_plus__endsuper_] ↔ [Ca_super_2_plus__endsuper_.CaM];  
 
 D1-4 [Ca_super_2_plus__endsuper_.CaM] + [Ca_super_2_plus__endsuper_] ↔ [2Ca_super_2_plus__endsuper_.CaM];  
 
 D1-6 [3Ca_super_2_plus__endsuper_.CaM] + [Ca_super_2_plus__endsuper_] ↔ [4Ca_super_2_plus__endsuper_.CaM];  
 
 D1-5 [2Ca_super_2_plus__endsuper_.CaM] + [Ca_super_2_plus__endsuper_] ↔ [3Ca_super_2_plus__endsuper_.CaM];  
 
 D1-10 [4Ca_super_2_plus__endsuper_.CaM] + [MLCK] ↔ [MLCK.4Ca_super_2_plus__endsuper_.CaM];  
 
 D1-9 [3Ca_super_2_plus__endsuper_.CaM] + [MLCK] ↔ [MLCK.3Ca_super_2_plus__endsuper_.CaM];  
 
 D1-8 [2Ca_super_2_plus__endsuper_.CaM] + [MLCK] ↔ [MLCK.2Ca_super_2_plus__endsuper_.CaM];  
 
 D1-7 [Ca_super_2_plus__endsuper_.CaM] + [MLCK] ↔ [MLCK.Ca_super_2_plus__endsuper_.CaM];  
 
 E1-1 [PKC] ↔ [PKC active1];  
 
 E1-3 [PKC] + [DAG] ↔ [PKC.DAG];  
 
 E1-5 [PKC.Ca_super_2_plus__endsuper_] ↔ [PKC active_2];  
 
 E1-4 [PKC] + [Ca_super_2_plus__endsuper_] ↔ [PKC.Ca_super_2_plus__endsuper_];  
 
 D2-1.2 [Ca_super_2_plus__endsuper_ pump.Ca_super_2_plus__endsuper_] → [Ca_super_2_plus__endsuper_ pump] + [Ca_super_2_plus__endsuper_ ext];  
 
 D1-1 [Ca_super_2_plus__endsuper_ trunsp] + 2.0 × [Ca_super_2_plus__endsuper_] ↔ [2Ca_super_2_plus__endsuper_ .Ca_super_2_plus__endsuper_ trunsp];  
 
 E1-7 [PKC.Ca_super_2_plus__endsuper_] + [DAG] ↔ [PKC.Ca_super_2_plus__endsuper_.DAG];  
 
 E1-8 [PKC.Ca_super_2_plus__endsuper_.DAG] ↔ [PKC active_3];  
 
 E1-9 [PKC active_3] → [csa39_degraded];  
 
 E1-6 [PKC active_2] → [csa36_degraded];  
 
 E1-2 [PKC active1] → [csa35_degraded];  
 
 D2-1.1 [Ca_super_2_plus__endsuper_ pump] + [Ca_super_2_plus__endsuper_] ↔ [Ca_super_2_plus__endsuper_ pump.Ca_super_2_plus__endsuper_];  
 
 E2-1.1.3 [PKC active_3] + [CPI-17] ↔ [PKC active_3.CPI];  
 
 E2-1.1.2 [PKC active_2] + [CPI-17] ↔ [PKC active_2.CPI];  
 
 E2-1.1.1 [PKC active1] + [CPI-17] ↔ [PKC active_1.CPI];  
 
 E2-1.2.3 [PKC active_3.CPI] → [PKC active_3] + [CPI-17];  
 
 E2-1.2.2 [PKC active_2.CPI] → [PKC active_2] + [CPI-17];  
 
 E2-1.2.1 [PKC active_1.CPI] → [PKC active1] + [CPI-17];  
 
 E1-10 [CPI-17] → [CPI-17];  
 
 E1-11 [MYPT1_PPase] + [CPI-17] ↔ [CPI-17.MYPT1_PPase];  
 
 E1-12 [MYPT1_PPase] + [CPI-17] ↔ [CPI-17.MYPT1_PPase];  
 
 E1-13 [CPI-17.MYPT1_PPase] → [CPI-17.MYPT1_PPase];  
 
 F2-1.1 [Rho-kinase] + [MLC] ↔ [Rho-kinase.MLC];  
 
 F2-2.1 [Rho-kinase] + [MLC] ↔ [Rho-kinase.MLC];  
 
 F2-1.2 [Rho-kinase.MLC] → [MLC] + [Rho-kinase];  
 
 F2-2.2 [Rho-kinase.MLC] → [MLC] + [Rho-kinase];  
 
 F2-3.1 [Rho.GTP.Rho-kinase] + [MLC] ↔ [Rho.GTP.Rho-kinase.MLC];  
 
 F2-4.1 [Rho.GTP.Rho-kinase] + [MLC] → [Rho.GTP.Rho-kinase.MLC];  
 
 F2-3.2 [Rho.GTP.Rho-kinase.MLC] → [Rho.GTP.Rho-kinase] + [MLC];  
 
 F2-4.2 [Rho.GTP.Rho-kinase.MLC] → [Rho.GTP.Rho-kinase] + [MLC];  
 
 F2-14.1 [Rho-kinase] + [MYPT1_PPase] ↔ [MYPT1.Rho-kinase];  
 
 F2-14.2 [MYPT1.Rho-kinase] → [Rho-kinase] + [MYPT1_PPase];  
 
 F2-13.1 [Rho.GTP.Rho-kinase] + [MYPT1_PPase] ↔ [MYPT1.Rho-kinase];  
 
 F2-13.2 [MYPT1.Rho-kinase] → [Rho.GTP.Rho-kinase] + [MYPT1_PPase];  
 
 F2-11.1 [MLC] + [MYPT1_PPase] ↔ [MYPT1.MLC];  
 
 F2-9.1 [MLC] + [MYPT1_PPase] ↔ [MYPT1.MLC];  
 
 F2-12.1 [MLC] + [MYPT1_PPase] ↔ [MYPT1.MLC];  
 
 F2-10.1 [MLC] + [MYPT1_PPase] ↔ [MYPT1.MLC];  
 
 F2-11.2 [MYPT1.MLC] → [MLC] + [MYPT1_PPase];  
 
 F2-9.2 [MYPT1.MLC] → [MLC] + [MYPT1_PPase];  
 
 F2-12.2 [MYPT1.MLC] → [MLC] + [MYPT1_PPase];  
 
 F2-10.2 [MYPT1.MLC] → [MLC] + [MYPT1_PPase];  
 
 F1-1 [MYPT1_PPase] → [MYPT1_PPase];  
 
 F2-7.1 [MLC] + [MLCK] ↔ [MLCK.MLC];  
 
 F2-8.1 [MLC] + [MLCK] ↔ [MLCK.MLC];  
 
 F2-7.2 [MLCK.MLC] → [MLC] + [MLCK];  
 
 F2-8.2 [MLCK.MLC] → [MLC] + [MLCK];  
 
 F2-5.1.1 [MLC] + [MLCK.Ca_super_2_plus__endsuper_.CaM] ↔ [MLCK.Ca_super_2_plus__endsuper_.CaM.MLC];  
 
 F2-5.2.1 [MLC] + [MLCK.2Ca_super_2_plus__endsuper_.CaM] ↔ [MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC];  
 
 F2-5.3.1 [MLC] + [MLCK.3Ca_super_2_plus__endsuper_.CaM] ↔ [MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC];  
 
 F2-5.4.1 [MLC] + [MLCK.4Ca_super_2_plus__endsuper_.CaM] ↔ [MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC];  
 
 F2-6.1.1 [MLC] + [MLCK.Ca_super_2_plus__endsuper_.CaM] ↔ [MLCK.Ca_super_2_plus__endsuper_.CaM.MLC];  
 
 F2-6.2.1 [MLC] + [MLCK.2Ca_super_2_plus__endsuper_.CaM] ↔ [MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC];  
 
 F2-6.3.1 [MLC] + [MLCK.3Ca_super_2_plus__endsuper_.CaM] ↔ [MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC];  
 
 F2-6.4.1 [MLC] + [MLCK.4Ca_super_2_plus__endsuper_.CaM] ↔ [MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC];  
 
 F2-6.4.2 [MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC] → [MLC] + [MLCK.4Ca_super_2_plus__endsuper_.CaM];  
 
 F2-5.4.2 [MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC] → [MLC] + [MLCK.4Ca_super_2_plus__endsuper_.CaM];  
 
 F2-6.3.2 [MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC] → [MLC] + [MLCK.3Ca_super_2_plus__endsuper_.CaM];  
 
 F2-5.3.2 [MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC] → [MLC] + [MLCK.3Ca_super_2_plus__endsuper_.CaM];  
 
 F2-6.2.2 [MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC] → [MLC] + [MLCK.2Ca_super_2_plus__endsuper_.CaM];  
 
 F2-5.2.2 [MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC] → [MLC] + [MLCK.2Ca_super_2_plus__endsuper_.CaM];  
 
 F2-6.1.2 [MLCK.Ca_super_2_plus__endsuper_.CaM.MLC] → [MLC] + [MLCK.Ca_super_2_plus__endsuper_.CaM];  
 
 F2-5.1.2 [MLCK.Ca_super_2_plus__endsuper_.CaM.MLC] → [MLC] + [MLCK.Ca_super_2_plus__endsuper_.CaM];  
 
 D3-3 [Ca_super_2_plus__endsuper_ ext] ↔ [Ca_super_2_plus__endsuper_];   {Ca_super_2_plus__endsuper_ ext leak}
 
 D3-2 [Ca_super_2_plus__endsuper_ store] ↔ [Ca_super_2_plus__endsuper_];   {Ca_super_2_plus__endsuper_ int leak}
 
Events (1)
 
 event_0000001
thrombin = 0.01
 
   Default Spatial dimensions: 3.0  Compartment size: 1.0
 
 thrombin
Compartment: Default
Initial concentration: 0.0
 
 thrombin_ligand
Compartment: Default
Initial concentration: 0.0
 
 Ca_super_2_plus__endsuper_ ext
Compartment: Default
Initial concentration: 4000.0
Constant
 
 cytosol Spatial dimensions: 3.0  Compartment size: 1.0
 
 thrombin_R
Compartment: cytosol
Initial concentration: 0.0
 
 pro_thrombinR
Compartment: cytosol
Initial concentration: 0.42
 
 thrombinR active
Compartment: cytosol
Initial concentration: 0.0
 
 RGS
Compartment: cytosol
Initial concentration: 0.2
 
 Inositol
Compartment: cytosol
Initial concentration: 0.0
 
   sa40_degraded
Compartment: cytosol
Initial concentration: 0.0
 
 thrombinR
Compartment: cytosol
Initial concentration: 0.0
 
 RGS
Compartment: cytosol
Initial concentration: 0.0
 
 GTP
Compartment: cytosol
Initial concentration: 50.0
 
 G_sub_q_endsub__alpha_.GTP
Compartment: cytosol
Initial concentration: 0.0
 
 GDP
Compartment: cytosol
Initial concentration: 5.0
 
 IP3R
Compartment: cytosol
Initial concentration: 0.008333
 
 3IP3.IP3R
Compartment: cytosol
Initial concentration: 0.0
 
 p115RhoGEF
Compartment: cytosol
Initial concentration: 0.1
 
 Rho-kinase
Compartment: cytosol
Initial concentration: 0.042
 
 RhoGAP
Compartment: cytosol
Initial concentration: 0.1
 
 DAG
Compartment: cytosol
Initial concentration: 0.0
 
 IP3
Compartment: cytosol
Initial concentration: 0.3
 
 Rho_GAP
Compartment: cytosol
Initial concentration: 0.0
 
 Rho.GTP
Compartment: cytosol
Initial concentration: 0.0050
 
 PIP2
Compartment: cytosol
Initial concentration: 10.0
 
   PC
Compartment: cytosol
Initial concentration: 0.0
 
 Rho.GDP
Compartment: cytosol
Initial concentration: 0.09
 
 Rho_GEF
Compartment: cytosol
Initial concentration: 0.0
 
   Rho_GEF_active
Compartment: cytosol
Initial concentration: 0.0
 
 Rho.GTP.Rho-kinase
Compartment: cytosol
Initial concentration: 0.0050
 
 Ca_super_2_plus__endsuper_.CaM
Compartment: cytosol
Initial concentration: 0.3
 
 2Ca_super_2_plus__endsuper_.CaM
Compartment: cytosol
Initial concentration: 0.0
 
 3Ca_super_2_plus__endsuper_.CaM
Compartment: cytosol
Initial concentration: 0.0
 
 4Ca_super_2_plus__endsuper_.CaM
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK
Compartment: cytosol
Initial concentration: 0.69
 
 MLCK.Ca_super_2_plus__endsuper_.CaM
Compartment: cytosol
Initial concentration: 0.05
 
 MLCK.2Ca_super_2_plus__endsuper_.CaM
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.3Ca_super_2_plus__endsuper_.CaM
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.4Ca_super_2_plus__endsuper_.CaM
Compartment: cytosol
Initial concentration: 0.0
 
 PKC
Compartment: cytosol
Initial concentration: 2.0
 
 PKC active1
Compartment: cytosol
Initial concentration: 0.039823
 
 PKC.DAG
Compartment: cytosol
Initial concentration: 0.0
 
 PKC active_2
Compartment: cytosol
Initial concentration: 0.68193
 
 PKC active_3
Compartment: cytosol
Initial concentration: 0.0
 
   csa39_degraded
Compartment: cytosol
Initial concentration: 0.0
 
   csa36_degraded
Compartment: cytosol
Initial concentration: 0.0
 
   csa35_degraded
Compartment: cytosol
Initial concentration: 0.0
 
 PKC active_1.CPI
Compartment: cytosol
Initial concentration: 0.0
 
 PKC active_2.CPI
Compartment: cytosol
Initial concentration: 0.0
 
 PKC active_3.CPI
Compartment: cytosol
Initial concentration: 0.0
 
 CPI-17.MYPT1_PPase
Compartment: cytosol
Initial concentration: 0.0
 
 CPI-17.MYPT1_PPase
Compartment: cytosol
Initial concentration: 0.0
 
 CPI-17
Compartment: cytosol
Initial concentration: 0.059
 
 MLC
Compartment: cytosol
Initial concentration: 0.1
 
 MLC
Compartment: cytosol
Initial concentration: 4.3
 
 Rho-kinase.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 Rho-kinase.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 CPI-17
Compartment: cytosol
Initial concentration: 0.0
 
 Ca_super_2_plus__endsuper_
Compartment: cytosol
Initial concentration: 0.0833
 
 CaM
Compartment: cytosol
Initial concentration: 19.65
 
 G_beta__gamma__1
Compartment: cytosol
Initial concentration: 0.0
 
 G_beta__gamma__2
Compartment: cytosol
Initial concentration: 0.0
 
 PLC_beta_
Compartment: cytosol
Initial concentration: 0.57
 
 Ca_super_2_plus__endsuper_ trunsp
Compartment: cytosol
Initial concentration: 0.5
 
 Ca_super_2_plus__endsuper_ pump
Compartment: cytosol
Initial concentration: 0.1
 
 G_sub_12_endsub__alpha__beta__gamma__thrombinR active
Compartment: cytosol
Initial concentration: 0.0
 
 p115RhoGEF.GTP_alpha_
Compartment: cytosol
Initial concentration: 0.0
 
 G_sub_12_endsub__alpha__beta__gamma_
Compartment: cytosol
Initial concentration: 0.5
 
 G_sub_12_endsub__alpha_.GDP
Compartment: cytosol
Initial concentration: 0.0
 
 G_sub_12_endsub__alpha_.GTP
Compartment: cytosol
Initial concentration: 0.0
 
 G_sub_q_endsub__alpha_.GDP
Compartment: cytosol
Initial concentration: 0.0
 
 G_sub_q_endsub__alpha__beta__gamma__thrombinR active
Compartment: cytosol
Initial concentration: 0.0
 
 G_sub_q_endsub__alpha__beta__gamma_
Compartment: cytosol
Initial concentration: 0.5
 
 PLC_beta_.G_sub_q_endsub__alpha_.GTP
Compartment: cytosol
Initial concentration: 0.0
 
 2Ca_super_2_plus__endsuper_ .Ca_super_2_plus__endsuper_ trunsp
Compartment: cytosol
Initial concentration: 0.0
 
 Ca_super_2_plus__endsuper_ pump.Ca_super_2_plus__endsuper_
Compartment: cytosol
Initial concentration: 0.0
 
 Rho.GTP.Rho-kinase.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 Rho.GTP.Rho-kinase.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLC
Compartment: cytosol
Initial concentration: 0.6
 
 MYPT1.Rho-kinase
Compartment: cytosol
Initial concentration: 0.0
 
 MYPT1.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MYPT1.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MYPT1.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MYPT1.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MYPT1.Rho-kinase
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.Ca_super_2_plus__endsuper_.CaM.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 MLCK.Ca_super_2_plus__endsuper_.CaM.MLC
Compartment: cytosol
Initial concentration: 0.0
 
 Ca_super_2_plus__endsuper_ ext leak
Compartment: cytosol
Initial concentration: 0.00833
Constant
 
 Ca_super_2_plus__endsuper_ int leak
Compartment: cytosol
Initial concentration: 0.0010
Constant
 
 PLC_beta_.G_sub_q_endsub__alpha_.GTP.Ca_super_2_plus__endsuper_
Compartment: cytosol
Initial concentration: 0.0
 
 PKC.Ca_super_2_plus__endsuper_.DAG
Compartment: cytosol
Initial concentration: 0.0
 
 PKC.Ca_super_2_plus__endsuper_
Compartment: cytosol
Initial concentration: 0.094
 
 PLC_beta_.G_sub_q_endsub_.GTP.Ca.PIP2
Compartment: cytosol
Initial concentration: 0.0
 
 PLC_beta_.Ca.PIP2
Compartment: cytosol
Initial concentration: 0.08
 
 PLC_beta_.Ca_super_2_plus__endsuper_
Compartment: cytosol
Initial concentration: 0.15
 
 MYPT1_PPase
Compartment: cytosol
Initial concentration: 0.7
 
 MYPT1_PPase
Compartment: cytosol
Initial concentration: 0.4941
 
 ER Spatial dimensions: 3.0  Compartment size: 0.1
 
 Ca_super_2_plus__endsuper_ store
Compartment: ER
Initial concentration: 155.0
 
A2-1.1 (3)
 
   Km
Value: 5.0   (Units: microMolar)
Constant
 
   ratio
Value: 4.0   (Units: dimensionless)
Constant
 
   Vmax
Value: 15.0   (Units: per_sec)
Constant
 
A1-2 (1)
 
   kf
Value: 0.01   (Units: per_uM_per_sec)
Constant
 
A1-5.1 (1)
 
   kf
Value: 0.00224   (Units: per_sec)
Constant
 
A1-3 (2)
 
   kf
Value: 1.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.0060   (Units: per_sec)
Constant
 
A1-4 (1)
 
   kf
Value: 0.01   (Units: per_uM_per_sec)
Constant
 
A1-6 (1)
 
   kf
Value: 0.0133   (Units: per_sec)
Constant
 
A1-7 (1)
 
   kf
Value: 0.01   (Units: per_uM_per_sec)
Constant
 
A2-2.1 (3)
 
   Km
Value: 0.05   (Units: microMolar)
Constant
 
   ratio
Value: 23.51   (Units: dimensionless)
Constant
 
   Vmax
Value: 0.0102   (Units: per_sec)
Constant
 
A1-9 (1)
 
   kf
Value: 0.01   (Units: per_uM_per_sec)
Constant
 
B1-1 (2)
 
   kf
Value: 20.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.1   (Units: per_sec)
Constant
 
B2-1.1 (2)
 
   Km
Value: 0.015   (Units: microMolar)
Constant
 
   Vmax
Value: 0.052   (Units: per_sec)
Constant
 
B2-2.1 (3)
 
   Km
Value: 2.0   (Units: microMolar)
Constant
 
   ratio
Value: 4.0   (Units: dimensionless)
Constant
 
   Vmax
Value: 0.04   (Units: per_sec)
Constant
 
B2-3.1 (3)
 
   Km
Value: 2.83   (Units: microMolar)
Constant
 
   ratio
Value: 13.246   (Units: dimensionless)
Constant
 
   Vmax
Value: 0.993   (Units: per_sec)
Constant
 
B2-1.2 (1)
 
   Vmax
Value: 0.04   (Units: per_sec)
Constant
 
B2-3.2 (1)
 
   Vmax
Value: 0.9933   (Units: per_sec)
Constant
 
A2-2.2 (1)
 
   Vmax
Value: 0.0102   (Units: per_sec)
Constant
 
B1-2 (1)
 
   kf
Value: 0.0117   (Units: per_sec)
Constant
 
B1-3 (1)
 
   kf
Value: 3.667E-4   (Units: per_sec)
Constant
 
B1-4 (2)
 
   kf
Value: 10.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.5   (Units: per_sec)
Constant
 
A2-1.2 (1)
 
   Vmax
Value: 15.0   (Units: per_sec)
Constant
 
A1-1 (2)
 
   kf
Value: 1.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.0060   (Units: per_sec)
Constant
 
A1-8 (1)
 
   kf
Value: 0.0133   (Units: per_sec)
Constant
 
A1-5.2 (1)
 
   kf
Value: 0.00224   (Units: per_sec)
Constant
 
C1-2 (2)
 
   kf
Value: 25.201   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 1.0   (Units: per_sec)
Constant
 
C1-3 (2)
 
   kf
Value: 2.5201   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 1.0   (Units: per_sec)
Constant
 
C1-4 (2)
 
   kf
Value: 30.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 1.0   (Units: per_sec)
Constant
 
C1-1 (2)
 
   kf
Value: 3.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 1.0   (Units: per_sec)
Constant
 
C1-5 (1)
 
   kf
Value: 0.0133   (Units: per_sec)
Constant
 
C2-1.1 (3)
 
   Km
Value: 19.841   (Units: microMolar)
Constant
 
   ratio
Value: 4.0   (Units: dimensionless)
Constant
 
   Vmax
Value: 10.0   (Units: per_sec)
Constant
 
C2-2.1 (3)
 
   Km
Value: 5.0   (Units: microMolar)
Constant
 
   ratio
Value: 4.0   (Units: dimensionless)
Constant
 
   Vmax
Value: 48.0   (Units: per_sec)
Constant
 
C2-1.2 (1)
 
   Vmax
Value: 10.0   (Units: per_sec)
Constant
 
C2-2.2 (1)
 
   Vmax
Value: 48.0   (Units: per_sec)
Constant
 
C1-6 (1)
 
   kf
Value: 0.15   (Units: per_sec)
Constant
 
C1-7 (1)
 
   kf
Value: 2.5   (Units: per_sec)
Constant
 
C1-8 (2)
 
   kf
Value: 0.1   (Units: per_uM3_per_sec)
Constant
 
   kb
Value: 10.0   (Units: per_sec)
Constant
 
D3-1 (1)
 
   g
Value: 150.0   (Units: per_uM_per_sec)
Constant
 
D1-2 (1)
 
   kf
Value: 1.0   (Units: per_sec)
Constant
 
D1-3 (2)
 
   kf
Value: 10.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 50.0   (Units: per_sec)
Constant
 
D1-4 (2)
 
   kf
Value: 10.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 45.0   (Units: per_sec)
Constant
 
D1-6 (2)
 
   kf
Value: 10.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 500.0   (Units: per_sec)
Constant
 
D1-5 (2)
 
   kf
Value: 10.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 170.0   (Units: per_sec)
Constant
 
D1-10 (2)
 
   kf
Value: 10.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.01   (Units: per_sec)
Constant
 
D1-9 (2)
 
   kf
Value: 10.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.01   (Units: per_sec)
Constant
 
D1-8 (2)
 
   kf
Value: 0.1   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.45   (Units: per_sec)
Constant
 
D1-7 (2)
 
   kf
Value: 0.1   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.5   (Units: per_sec)
Constant
 
E1-1 (2)
 
   kf
Value: 1.0   (Units: per_sec)
Constant
 
   kb
Value: 50.0   (Units: per_sec)
Constant
 
E1-3 (2)
 
   kf
Value: 3.0E-4   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.1   (Units: per_sec)
Constant
 
E1-5 (2)
 
   kf
Value: 1.2705   (Units: per_sec)
Constant
 
   kb
Value: 3.5026   (Units: per_sec)
Constant
 
E1-4 (2)
 
   kf
Value: 0.3   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.5   (Units: per_sec)
Constant
 
D2-1.2 (1)
 
   Vmax
Value: 4.9   (Units: per_sec)
Constant
 
D1-1 (2)
 
   kf
Value: 30.0   (Units: per_uM2_per_sec)
Constant
 
   kb
Value: 3.0   (Units: per_sec)
Constant
 
E1-7 (2)
 
   kf
Value: 0.0040   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 8.6348   (Units: per_sec)
Constant
 
E1-8 (2)
 
   kf
Value: 1.0   (Units: per_sec)
Constant
 
   kb
Value: 0.1   (Units: per_sec)
Constant
 
E1-9 (1)
 
   kf
Value: 4.63E-5   (Units: per_sec)
Constant
 
E1-6 (1)
 
   kf
Value: 4.63E-5   (Units: per_sec)
Constant
 
E1-2 (1)
 
   kf
Value: 4.63E-5   (Units: per_sec)
Constant
 
D2-1.1 (3)
 
   Km
Value: 0.04   (Units: microMolar)
Constant
 
   ratio
Value: 4.0   (Units: dimensionless)
Constant
 
   Vmax
Value: 4.9   (Units: per_sec)
Constant
 
E2-1.1.3 (3)
 
   Km
Value: 0.0014   (Units: microMolar)
Constant
 
   ratio
Value: 4.0   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.94   (Units: per_sec)
Constant
 
E2-1.1.2 (3)
 
   Km
Value: 0.0014   (Units: microMolar)
Constant
 
   ratio
Value: 4.0   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.94   (Units: per_sec)
Constant
 
E2-1.1.1 (3)
 
   Km
Value: 0.0014   (Units: microMolar)
Constant
 
   ratio
Value: 4.0   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.94   (Units: per_sec)
Constant
 
E2-1.2.3 (1)
 
   Vmax
Value: 3.94   (Units: per_sec)
Constant
 
E2-1.2.2 (1)
 
   Vmax
Value: 3.94   (Units: per_sec)
Constant
 
E2-1.2.1 (1)
 
   Vmax
Value: 3.94   (Units: per_sec)
Constant
 
E1-10 (1)
 
   kf
Value: 0.5   (Units: per_sec)
Constant
 
E1-11 (2)
 
   kf
Value: 100.0   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.62   (Units: per_sec)
Constant
 
E1-12 (2)
 
   kf
Value: 0.01   (Units: per_uM_per_sec)
Constant
 
   kb
Value: 0.1   (Units: per_sec)
Constant
 
E1-13 (1)
 
   kf
Value: 0.5   (Units: per_sec)
Constant
 
F2-1.1 (3)
 
   Km
Value: 4.5099   (Units: microMolar)
Constant
 
   ratio
Value: 16.617   (Units: dimensionless)
Constant
 
   Vmax
Value: 1.28   (Units: per_sec)
Constant
 
F2-2.1 (3)
 
   Km
Value: 4.5099   (Units: microMolar)
Constant
 
   ratio
Value: 16.617   (Units: dimensionless)
Constant
 
   Vmax
Value: 1.28   (Units: per_sec)
Constant
 
F2-1.2 (1)
 
   Vmax
Value: 1.28   (Units: per_sec)
Constant
 
F2-2.2 (1)
 
   Vmax
Value: 1.28   (Units: per_sec)
Constant
 
F2-3.1 (3)
 
   Km
Value: 2.47   (Units: microMolar)
Constant
 
   ratio
Value: 0.4261   (Units: dimensionless)
Constant
 
   Vmax
Value: 8.66   (Units: per_sec)
Constant
 
F2-4.1 (3)
 
   Km
Value: 2.47   (Units: microMolar)
Constant
 
   ratio
Value: 0.4261   (Units: dimensionless)
Constant
 
   Vmax
Value: 8.66   (Units: per_sec)
Constant
 
F2-3.2 (1)
 
   Vmax
Value: 8.66   (Units: per_sec)
Constant
 
F2-4.2 (1)
 
   Vmax
Value: 8.66   (Units: per_sec)
Constant
 
F2-14.1 (3)
 
   Km
Value: 0.18   (Units: microMolar)
Constant
 
   ratio
Value: 0.23288   (Units: dimensionless)
Constant
 
   Vmax
Value: 1.46   (Units: per_sec)
Constant
 
F2-14.2 (1)
 
   Vmax
Value: 1.46   (Units: per_sec)
Constant
 
F2-13.1 (3)
 
   Km
Value: 0.1   (Units: microMolar)
Constant
 
   ratio
Value: 0.028278   (Units: dimensionless)
Constant
 
   Vmax
Value: 17.505   (Units: per_sec)
Constant
 
F2-13.2 (1)
 
   Vmax
Value: 17.505   (Units: per_sec)
Constant
 
F2-11.1 (3)
 
   Km
Value: 58.099   (Units: microMolar)
Constant
 
   ratio
Value: 28.795   (Units: dimensionless)
Constant
 
   Vmax
Value: 1.95   (Units: per_sec)
Constant
 
F2-9.1 (3)
 
   Km
Value: 16.0   (Units: microMolar)
Constant
 
   ratio
Value: 7.5865   (Units: dimensionless)
Constant
 
   Vmax
Value: 9.317   (Units: per_sec)
Constant
 
F2-12.1 (3)
 
   Km
Value: 58.099   (Units: microMolar)
Constant
 
   ratio
Value: 28.795   (Units: dimensionless)
Constant
 
   Vmax
Value: 1.95   (Units: per_sec)
Constant
 
F2-10.1 (3)
 
   Km
Value: 16.0   (Units: microMolar)
Constant
 
   ratio
Value: 7.5865   (Units: dimensionless)
Constant
 
   Vmax
Value: 9.317   (Units: per_sec)
Constant
 
F2-11.2 (1)
 
   Vmax
Value: 1.95   (Units: per_sec)
Constant
 
F2-9.2 (1)
 
   Vmax
Value: 9.317   (Units: per_sec)
Constant
 
F2-12.2 (1)
 
   Vmax
Value: 1.95   (Units: per_sec)
Constant
 
F2-10.2 (1)
 
   Vmax
Value: 9.317   (Units: per_sec)
Constant
 
F1-1 (1)
 
   kf
Value: 0.2   (Units: per_sec)
Constant
 
F2-7.1 (3)
 
   Km
Value: 148.08   (Units: microMolar)
Constant
 
   ratio
Value: 39.349   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-8.1 (3)
 
   Km
Value: 148.08   (Units: microMolar)
Constant
 
   ratio
Value: 39.349   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-7.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-8.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-5.1.1 (3)
 
   Km
Value: 10.019   (Units: microMolar)
Constant
 
   ratio
Value: 1.7299   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-5.2.1 (3)
 
   Km
Value: 10.019   (Units: microMolar)
Constant
 
   ratio
Value: 1.7299   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-5.3.1 (3)
 
   Km
Value: 10.019   (Units: microMolar)
Constant
 
   ratio
Value: 1.7299   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-5.4.1 (3)
 
   Km
Value: 10.019   (Units: microMolar)
Constant
 
   ratio
Value: 1.7299   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-6.1.1 (3)
 
   Km
Value: 10.019   (Units: microMolar)
Constant
 
   ratio
Value: 1.7299   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-6.2.1 (3)
 
   Km
Value: 10.019   (Units: microMolar)
Constant
 
   ratio
Value: 1.7299   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-6.3.1 (3)
 
   Km
Value: 10.019   (Units: microMolar)
Constant
 
   ratio
Value: 1.7299   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-6.4.1 (3)
 
   Km
Value: 10.019   (Units: microMolar)
Constant
 
   ratio
Value: 1.7299   (Units: dimensionless)
Constant
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-6.4.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-5.4.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-6.3.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-5.3.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-6.2.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-5.2.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-6.1.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
F2-5.1.2 (1)
 
   Vmax
Value: 3.67   (Units: per_sec)
Constant
 
D3-3 (1)
 
   g
Value: 0.01   (Units: per_uM_per_sec)
Constant
 
D3-2 (1)
 
   g
Value: 0.01   (Units: per_uM_per_sec)
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000088

Curator's comment: (updated: 24 Jan 2007 01:59:09 GMT)

Plots correspond to Fig 2B, D, F, and 2H of the paper. Results obtained from Cell Designer.

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