Please visit the new BioModels platform to access the latest content. This website is no longer updated and will be retired on 31 May 2019.
BioModels Database logo

BioModels Database


MODEL1606100000 - Talemi2016 - Yeast osmo-homoestasis


The following model is part of the non-curated branch of BioModels Database. While the syntax of the model has been verified, its semantics remains unchecked. Any annotation present in the models is not a product of BioModels' annotators. We are doing our best to incorporate this model into the curated branch as soon as possible. In the meantime, we display only limited metadata here. For further information about the model, please download the SBML file.

 |   |   |  Send feedback
Reference Publication
Publication ID: 27515486
Talemi SR, Tiger CF, Andersson M, Babazadeh R, Welkenhuysen N, Klipp E, Hohmann S, Schaber J.
Systems Level Analysis of the Yeast Osmo-Stat.
Sci Rep 2016; 6: 30950
Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.  [more]
Original Model: MODEL1606100000.origin
Submitter: Soheil Rastgou Talemi
Submission Date: 10 Jun 2016 08:56:21 UTC
Last Modification Date: 03 May 2017 13:14:54 UTC
Creation Date: 22 Jul 2010 09:44:09 UTC
Encoders:  Joerg Schaber
   Soheil Rastgou Talemi
Talemi2016 - Yeast osmo-homoestasis

This model is described in the article:

Talemi SR, Tiger CF, Andersson M, Babazadeh R, Welkenhuysen N, Klipp E, Hohmann S, Schaber J.
Sci Rep 2016; 6: 30950


Adaptation is an important property of living organisms enabling them to cope with environmental stress and maintaining homeostasis. Adaptation is mediated by signaling pathways responding to different stimuli. Those signaling pathways might communicate in order to orchestrate the cellular response to multiple simultaneous stimuli, a phenomenon called crosstalk. Here, we investigate possible mechanisms of crosstalk between the High Osmolarity Glycerol (HOG) and the Cell Wall Integrity (CWI) pathways in yeast, which mediate adaptation to hyper- and hypo-osmotic challenges, respectively. We combine ensemble modeling with experimental investigations to test in quantitative terms different hypotheses about the crosstalk of the HOG and the CWI pathways. Our analyses indicate that for the conditions studied i) the CWI pathway activation employs an adaptive mechanism with a variable volume-dependent threshold, in contrast to the HOG pathway, whose activation relies on a fixed volume-dependent threshold, ii) there is no or little direct crosstalk between the HOG and CWI pathways, and iii) its mainly the HOG alone mediating adaptation of cellular osmotic pressure for both hyper- as well as hypo-osmotic stress. Thus, by iteratively combining mathematical modeling with experimentation we achieved a better understanding of regulatory mechanisms of yeast osmo-homeostasis and formulated new hypotheses about osmo-sensing.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.