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MODEL1011020000 - Kaizu2010_BuddingYeastCellCycle_Map


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Reference Publication
Publication ID: 20865008
Kaizu K, Ghosh S, Matsuoka Y, Moriya H, Shimizu-Yoshida Y, Kitano H.
A comprehensive molecular interaction map of the budding yeast cell cycle.
Mol. Syst. Biol. 2010 Sep; 6: 415
Department of Science and Technology, Keio University, Kanagawa, Japan.  [more]
Original Model:
Submitter: Lukas Endler
Submission Date: 02 Nov 2010 14:38:29 UTC
Last Modification Date: 27 Jul 2011 14:04:31 UTC
Creation Date: 02 Nov 2010 15:03:57 UTC
Non kinetic model: network icon.
bqbiol:isVersionOf Gene Ontology cell cycle
bqbiol:hasTaxon Taxonomy Saccharomyces cerevisiae

This is the map described in and accompanying the article:
A comprehensive molecular interaction map of the budding yeast cell cycle.
Kaizu K, Ghosh S, Matsuoka Y, Moriya H, Shimizu-Yoshida Y, Kitano H. Mol Syst Biol. 2010 Sep 21;6:415. Pmid: 20865008 ; doi: 10.1038/msb.2010.73
With the accumulation of data on complex molecular machineries coordinating cell-cycle dynamics, coupled with its central function in disease patho-physiologies, it is becoming increasingly important to collate the disparate knowledge sources into a comprehensive molecular network amenable to systems-level analyses. In this work, we present a comprehensive map of the budding yeast cell-cycle, curating reactions from ∼600 original papers. Toward leveraging the map as a framework to explore the underlying network architecture, we abstract the molecular components into three planes--signaling, cell-cycle core and structural planes. The planar view together with topological analyses facilitates network-centric identification of functions and control mechanisms. Further, we perform a comparative motif analysis to identify around 194 motifs including feed-forward, mutual inhibitory and feedback mechanisms contributing to cell-cycle robustness. We envisage the open access, comprehensive cell-cycle map to open roads toward community-based deeper understanding of cell-cycle dynamics.

This model was taken from the supplementary material of the original article ( Supplementary Data S1 ) and is best viewed with CellDesigner 4.1 and higher ( ).

Creators: Kazunari Kaizu (mail address), Samik Ghosh, Yukiko Matsuoka, Hisao Moriya, Yuki Shimizu-Yoshida, Hiroaki Kitano Creation date: Jan 2009 Last modification: 28th July 2010 Created by CellDesigner 4.1 ( Stored in CellDesigner annotated SBML Level 2 Version 4 format. (c) The Systems Biology Institute

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