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MODEL1005050000 - Salazar2009_PhotoperiodicRegulation

 

The following model is part of the non-curated branch of BioModels Database. While the syntax of the model has been verified, its semantics remains unchecked. Any annotation present in the models is not a product of BioModels' annotators. We are doing our best to incorporate this model into the curated branch as soon as possible. In the meantime, we display only limited metadata here. For further information about the model, please download the SBML file.


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Reference Publication
Publication ID: 20005809
Salazar JD, Saithong T, Brown PE, Foreman J, Locke JC, Halliday KJ, Carré IA, Rand DA, Millar AJ.
Prediction of photoperiodic regulators from quantitative gene circuit models.
Cell 2009 Dec; 139(6): 1170-1179
Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK.  [more]
Model
Original Model: Model 3 of the publication...
Submitter: Andrew J Millar
Submission Date: 05 May 2010 16:03:47 UTC
Last Modification Date: 31 Mar 2011 11:09:08 UTC
Creation Date: 31 Mar 2011 11:09:08 UTC
Encoders:
bqmodel:isDerivedFrom PubMed 16729048
PubMed 15784272
bqbiol:isVersionOf Gene Ontology circadian regulation of gene expression
bqbiol:hasTaxon Taxonomy Arabidopsis thaliana
Notes

This a model from the article:
Prediction of photoperiodic regulators from quantitative gene circuit models.
Salazar JD, Saithong T, Brown PE, Foreman J, Locke JC, Halliday KJ, Carré IA, Rand DA, Millar AJ Cell 2009 Dec; 139(6): 1170-9 20005809 ,
Abstract:
Photoperiod sensors allow physiological adaptation to the changing seasons. The prevalent hypothesis is that day length perception is mediated through coupling of an endogenous rhythm with an external light signal. Sufficient molecular data are available to test this quantitatively in plants, though not yet in mammals. In Arabidopsis, the clock-regulated genes CONSTANS (CO) and FLAVIN, KELCH, F-BOX (FKF1) and their light-sensitive proteins are thought to form an external coincidence sensor. Here, we model the integration of light and timing information by CO, its target gene FLOWERING LOCUS T (FT), and the circadian clock. Among other predictions, our models show that FKF1 activates FT. We demonstrate experimentally that this effect is independent of the known activation of CO by FKF1, thus we locate a major, novel controller of photoperiodism. External coincidence is part of a complex photoperiod sensor: modeling makes this complexity explicit and may thus contribute to crop improvement.


Note:

There are four models described in the paper. This model corresponds to model 3 (which is a combination of model 1 and model 2). The SBML file is redeveloped from Kevin S

This model is same as BIOMD0000000055 , but with revised light function.

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

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