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Phosphonate and phosphinate metabolism - Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
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Model information |
Identifier: |
BMID000000063650 |
Format: |
SBML L3 V1
(Layout)
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Submission: |
18 May 2012 05:09:26 UTC |
Last modified: |
10 Dec 2012 01:24:41 UTC |
Published: |
19 May 2012 23:49:21 UTC
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Notes |
Model of “Phosphonate and phosphinate metabolism” in “Klebsiella pneumoniae subsp. pneumoniae MGH 78578”
Natural products containing carbon-phosphorous bonds, so-called C-P compounds, are derivatives of phosphonate and phosphinate with substitution of alkyl group for hydrogen of phosphorus-hydrogen bonds. C-P compounds have been found in many organisms, but only protists and bacteria, mostly Actinobacteria, have biosynthetic capacity. A common reaction in the biosynthetic pathway is C-P bond forming reaction from phosphoenolpyruvate (PEP) to phosphonopyruvate (PnPy) catalyzed by PEP phosphomutase. 2-Aminoethylphosphonate (AEP) is the most abundant C-P compound in the natural world. AEP derivatives include phosphonoprotein, phosphonoglycan, and phosphonolipid. Other known C-P compounds are bioactive substances used in medicine (antibiotics) and agriculture (herbicide) such as fosfomycin, FR-33289, rhizocticin, and bialaphos.
This model has been automatically generated by KEGGtranslator
V2.2.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics
. 2011, 27
:2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway
).
The missing kinetic equations were added by SBMLsqueezer
.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication
for more information.
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