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Sesquiterpenoid biosynthesis - Streptomyces avermitilis MA-4680


Model information
Identifier: BMID000000038530
Format: SBML L3 V1 (Layout)
Project: path2models
Categories: metabolic
Submission: 17 May 2012 22:34:45 UTC
Last modified: 10 Dec 2012 10:13:27 UTC
Published: 19 May 2012 23:49:21 UTC
isDescribedBy triterpenoid biosynthetic process Gene Ontology
isDescribedBy sesquiterpenoid biosynthetic process Gene Ontology
occursIn Streptomyces avermitilis MA-4680 Taxonomy
isDerivedFrom Sesquiterpenoid biosynthesis KEGG Pathway
Model of “Sesquiterpenoid biosynthesis” in “Streptomyces avermitilis MA-4680”
Sesquiterpenoids (C15 terpenoids) are a group of terpenoids consisting of three isoprene units. They are derive from farnesyl diphosphate (FPP) and can be cyclized to produce various skeletal structures. Sesquiterpenoid biosynthesis begins with the loss of diphosphate from FPP under the action of sesquiterpene synthesis enzymes, generating an allylic cation that is highly susceptible to intramolecular attacks. Cyclization of the farnesyl cation may take place onto either of the remaining double bonds with the result that 6-, 10-, or 11-membered rings may be formed. Many sesquiterpenoids have been isolated from plants, fungi, marine organisms, and Streptomyces species. This map shows a few examples of acyclic and cyclic sesquiterpenoids.

Graphical representation of 'Sesquiterpenoid biosynthesis (Streptomyces avermitilis MA-4680)'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.2.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
The missing kinetic equations were added by SBMLsqueezer .
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000038530 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.