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Colorectal cancer (Homo sapiens (human)) - Homo sapiens

 

Model information
Identifier: BMID000000017788
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 16:59:47 UTC
Last modified: 07 Dec 2012 23:42:14 UTC
Published: 19 May 2012 23:49:21 UTC
Annotations
occursIn Homo sapiens Taxonomy
isDerivedFrom Colorectal cancer (Homo sapiens (human)) KEGG Pathway
Notes
Model of “Colorectal cancer” in “Homo sapiens (human)”
Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and inactivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from inactivation of the DNA mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated DNA mismatch repair genes in HNPCC).

Graphical representation of 'Colorectal cancer (Homo sapiens (human))'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
Some transition were added from the BioCarta import of PID: the Pathway Interaction Database .
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000017788 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
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