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Viral myocarditis - Canis familiaris

 

Model information
Identifier: BMID000000008910
Format: SBML L3 V1 (Layout, Qualitative Models)
Project: path2models
Categories: non-metabolic
Submission: 17 May 2012 15:22:38 UTC
Last modified: 07 Dec 2012 21:53:52 UTC
Published: 19 May 2012 23:49:21 UTC
Annotations
occursIn Canis familiaris Taxonomy
isDerivedFrom Viral myocarditis KEGG Pathway
Notes
Model of “Viral myocarditis” in “Canis lupus familiaris (dog)”
Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is still considered the dominant etiological agent. Myocarditis may be caused by direct cytopathic effects of virus, a pathologic immune response to persistent virus, or autoimmunity triggered by the viral infection. The virus enters the myocyte through internalization of the coxsackie-adenoviral receptor (CAR) and its coreceptor, decay-accelerating factor (DAF). Viral proteases cleave various proteins in the host cell. One example is viral protease 2A, which cleaves eukaryote initiation factor 4G (eIF4G) and the dystrophin protein, resulting in a complete shutdown of cap-dependent RNA translation and cytoskeletal destruction in infected cardiomyocytes, respectively. CVB3 also cleaves the member of the Bcl-2 family Bid, leading to apoptosis. CVB3 infection also induces the cleavage of cyclin D protein through a proteasome-dependent pathway, leading to the host cell-growth arrest. Viral infection and necrosis of myocytes may lead to the release of intracellular antigens, resulting in activation of self-reactive T cells. CVB infection is a significant cause of dilated cardiomyopathy (DCM) as well as myocarditis. Epidemiologically, myocarditis underlies a significant portion of patients with DCM.

Graphical representation of 'Viral myocarditis (Canis lupus familiaris (dog))'
(PNG image hosted by the Kyoto Encyclopedia of Genes and Genomes, KEGG).
This model has been automatically generated by KEGGtranslator V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics . 2011, 27 :2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway ).
This model has been produced by the path2models project, it is currently hosted on BioModels Database and identified by: BMID000000008910 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
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