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Shigellosis - Shigella boydii serotype 4 (strain Sb227)
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Model information |
Identifier: |
BMID000000000501 |
Format: |
SBML L3 V1
(Layout, Qualitative Models)
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Submission: |
17 May 2012 14:06:28 UTC |
Last modified: |
08 Dec 2012 01:49:58 UTC |
Published: |
19 May 2012 23:49:21 UTC
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Notes |
Model of “Shigellosis” in “Shigella boydii Sb227”
Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestinal epithelium by exploiting epithelial-cell functions and circumventing the host innate immune response. During basolateral entry into the host-cell cytoplasm, Shigella deliver a subset of effectors into the host cells through the type III secretion system. The effectors induce membrane ruffling through the stimulation of the Rac1-WAVE-Arp2/3 pathway, enabling bacterial entry into the epithelial cells. During multiplication within the cells, Shigella secrete another subset of effectors. VirG induces actin polymerization at one pole of the bacteria, allowing the bacteria to spread intracellularly and to infect adjacent cells. OspF, OspG and IpaH(9.8) downregulate the production of proinflammatory cytokines such as IL-8, helping bacteria circumvent the innate immune response.
This model has been automatically generated by KEGGtranslator
V2.3.0 (KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Wrzodek C, Dräger A, Zell A. Bioinformatics
. 2011, 27
:2314-2315) using information coming from the KEGG PATHWAY Database ( original pathway
).
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication
for more information.
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