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BIOMD0000000602 - Stavrum2013 - Tryptophan Metabolism in Liver

 

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Reference Publication
Publication ID: 24129579
Stavrum AK, Heiland I, Schuster S, Puntervoll P, Ziegler M.
Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data.
J. Biol. Chem. 2013 Nov; 288(48): 34555-34566
From the Department of Informatics, University of Bergen, N-5008 Bergen, Norway.  [more]
Model
Original Model: BIOMD0000000602.origin
Submitter: Ines Heiland
Submission ID: MODEL1310160000
Submission Date: 16 Oct 2013 12:36:57 UTC
Last Modification Date: 29 Mar 2018 09:44:19 UTC
Creation Date: 18 Apr 2016 14:06:05 UTC
Encoders:  Vijayalakshmi Chelliah
   Ines Heiland
   Ryan Gutenkunst
   Bao Charles
   Gillette Heather
   Lichauco Katrina
   Valenzuela Piriscilla
   Grover Jeffrey
   Ahmed Nasiha
   Trujillo Joshua
   Palazzola Dominic
set #1
bqbiol:occursIn Brenda Tissue Ontology BTO:0000759
bqbiol:isVersionOf Gene Ontology tryptophan metabolic process
Gene Ontology serotonin biosynthetic process from tryptophan
bqbiol:hasTaxon Taxonomy Homo sapiens
Notes
Stavrum2013 - Tryptophan Metabolism in Liver

This model is described in the article:

Stavrum AK, Heiland I, Schuster S, Puntervoll P, Ziegler M.
J. Biol. Chem. 2013 Nov; 288(48): 34555-34566

Abstract:

Tryptophan is utilized in various metabolic routes including protein synthesis, serotonin, and melatonin synthesis and the kynurenine pathway. Perturbations in these pathways have been associated with neurodegenerative diseases and cancer. Here we present a comprehensive kinetic model of the complex network of human tryptophan metabolism based upon existing kinetic data for all enzymatic conversions and transporters. By integrating tissue-specific expression data, modeling tryptophan metabolism in liver and brain returned intermediate metabolite concentrations in the physiological range. Sensitivity and metabolic control analyses identified expected key enzymes to govern fluxes in the branches of the network. Combining tissue-specific models revealed a considerable impact of the kynurenine pathway in liver on the concentrations of neuroactive derivatives in the brain. Moreover, using expression data from a cancer study predicted metabolite changes that resembled the experimental observations. We conclude that the combination of the kinetic model with expression data represents a powerful diagnostic tool to predict alterations in tryptophan metabolism. The model is readily scalable to include more tissues, thereby enabling assessment of organismal tryptophan metabolism in health and disease.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Model
Publication ID: 24129579 Submission Date: 16 Oct 2013 12:36:57 UTC Last Modification Date: 29 Mar 2018 09:44:19 UTC Creation Date: 18 Apr 2016 14:06:05 UTC
Mathematical expressions
Reactions
IL4I1 TDO DDC_Trypta KYNU_L-Kyn
TPH1 KAT1_L-Kyn AFMID_FKyn KMO
INMT_Trypta HAAO KYNU_3HKyn DDC_5HTrp
IDO_5HTrp WARS AFMID_5HFKyn Quinolic Acid formation (spontaneous)
MAOA_Trypta Cinnavalinate formation Tryptophan_Transport Slc7a5 IDO
QPRT KYNU_FKyn AFMID_FAA NMNAT1
ACMSD MAOA_Serotonin AANAT_Serotonin KAT1_3HKyn
IDO_Serotonin INMT_MTrypta INMT_Serotonin KAT2_3HKyn
KAT3_3HKyn KAT2_L-Kyn KAT3_L-Kyn MAOB_Serotonin
MAOB_Trypta AANAT_Trypta TPH2 Tryptophan_Transport Slc7a8
Lkynr_Transporter_Slc7a5 Lkynr_Transporter_Slc7a8    
Physical entities
Compartments Species
Cytosol M_3HAA M_5HFKyn M_5HTrp
M_5HKyn M_FKyn M_L-Kyn
M_AHCys M_Ketoglutarate M_L_ALA
M_AMet M_AA M_Acms
M_Dhbpt M_Formate M_LGlu
M_3HKyn M_IndolAc M_IndolP
M_MTrypta M_Quin M_Serotonin
M_Thbpt M_tRNA M_Trp
M_Trp_tRNA M_Trypta M_AMP
M_ATP M_CO2 M_H2O2
M_H2O M_H M_NADP
M_NADPH M_NH4 M_O2
M_O2s M_PPi M_Cin
M_Kyna Trp_ex M_NaMN
M_PRPP M_FAA M_NAAD
M_Am6sa M_5HAc M_NAcSet
M_AcetylCoA M_CoA M_Xanth
M_F5HKyn M_MMTrypta M_NMSer
M_Nactrypta M_LKyn_ex  
Global parameters
scaling KAT1_E_T KAT2_E_T KAT3_E_T
KAT_Km_3HKyn KAT_Km_L-kyn AANAT_E_T AANAT_Km_Serotonin
AANAT_Km_Trypta AFMID_E_T AFMID_Km_5HFKyn AFMID_Km_FKyn
AFMID_Km_FAA DDC_E_T DDC_Km_5htrp DDC_Km_Trp
IDO_E_T IDO_Km_Trp IDO_Km_5htrp IDO_Km_Serotonin
IMNT_E_T IMNT_Km_Serotonin IMNT_Km_Trypta IMNT_Km_MTrypta
KYNU_Km_3HKyn Transporter_E_T_Slc7a8 KYNU_E_T KYNU_Km_FKyn
KYNU_Km_L-kyn Transporter_Km_L-kyn Transporter_Km_Trp_Slc7a8 Transporter_E_T_Slc7a5
Transporter_Km_Trp_Slc7a5 MAOA_E_T MAOB_E_T MAO_Km_Serotonin
MAO_Km_Trypta IDO_Km_O2 KAT_kcat_3HKyn KAT_kcat_L-kyn
Transporter_kcat_Trp Transporter_kcat_L-kyn    
Reactions (42)
 
 IL4I1 [M_Trp] + [M_H2O] + [M_O2] → [M_IndolP] + [M_NH4] + [M_H2O2];   {M_H2O} , {M_O2} , {M_Trp}
 
 TDO [M_Trp] + [M_O2] → [M_FKyn];   {M_O2} , {M_Trp}
 
 DDC_Trypta [M_Trp] → [M_Trypta] + [M_CO2];   {M_5HTrp} , {M_Trp}
 
 KYNU_L-Kyn [M_L-Kyn] + [M_H2O] → [M_AA] + [M_L_ALA];   {M_3HKyn} , {M_FKyn} , {M_L-Kyn}
 
 TPH1 [M_Thbpt] + [M_Trp] + [M_O2] → [M_5HTrp] + [M_Dhbpt] + [M_H2O];   {M_O2} , {M_Thbpt} , {M_Trp}
 
 KAT1_L-Kyn [M_L-Kyn] + [M_Ketoglutarate] → [M_Kyna] + [M_LGlu];   {M_3HKyn} , {M_L-Kyn}
 
 AFMID_FKyn [M_FKyn] + [M_H2O] → [M_Formate] + [M_L-Kyn];   {M_5HFKyn} , {M_FAA} , {M_FKyn}
 
 KMO [M_L-Kyn] + [M_O2] + [M_NADPH] + [M_H] → [M_3HKyn] + [M_NADP] + [M_H2O];   {M_L-Kyn} , {M_H} , {M_NADPH} , {M_O2}
 
 INMT_Trypta [M_AMet] + [M_Trypta] → [M_AHCys] + [M_MTrypta];   {M_MTrypta} , {M_Serotonin} , {M_Trypta}
 
 HAAO [M_3HAA] + [M_O2] → [M_Acms];   {M_Quin} , {M_AA} , {M_3HAA} , {M_O2}
 
 KYNU_3HKyn [M_3HKyn] + [M_H2O] → [M_3HAA] + [M_L_ALA];   {M_L-Kyn} , {M_FKyn} , {M_3HKyn}
 
 DDC_5HTrp [M_5HTrp] → [M_Serotonin] + [M_CO2];   {M_Trp} , {M_5HTrp}
 
 IDO_5HTrp [M_5HTrp] + [M_O2] → [M_5HFKyn];   {M_Trp} , {M_Serotonin} , {M_5HTrp} , {M_O2}
 
 WARS [M_ATP] + [M_Trp] + [M_tRNA] → [M_AMP] + [M_PPi] + [M_Trp_tRNA];   {M_ATP} , {M_tRNA} , {M_Trp}
 
 AFMID_5HFKyn [M_5HFKyn] + [M_H2O] → [M_5HKyn] + [M_Formate];   {M_FKyn} , {M_FAA} , {M_5HFKyn}
 
 Quinolic Acid formation (spontaneous) [M_Acms] → [M_Quin];   {M_Acms}
 
 MAOA_Trypta [M_Trypta] + [M_H2O] + [M_O2] → [M_IndolAc] + [M_NH4] + [M_H2O2];   {M_Serotonin} , {M_Trypta}
 
 Cinnavalinate formation 2.0 × [M_3HAA] + 4.0 × [M_O2] → [M_Cin] + 2.0 × [M_O2s] + 2.0 × [M_H2O2] + 2.0 × [M_H];   {M_3HAA} , {M_O2}
 
 Tryptophan_Transport Slc7a5 [Trp_ex] ↔ [M_Trp];   {M_LKyn_ex} , {M_L-Kyn} , {M_Trp} , {Trp_ex}
 
 IDO [M_Trp] + [M_O2] → [M_FKyn];   {M_5HTrp} , {M_Serotonin} , {M_O2} , {M_Trp}
 
 QPRT [M_H] + [M_PRPP] + [M_Quin] → [M_CO2] + [M_NaMN] + [M_PPi];   {M_H} , {M_PRPP} , {M_Quin}
 
 KYNU_FKyn [M_FKyn] + [M_H2O] → [M_FAA] + [M_L_ALA];   {M_L-Kyn} , {M_3HKyn} , {M_FKyn}
 
 AFMID_FAA [M_FAA] + [M_H2O] → [M_Formate] + [M_AA];   {M_FKyn} , {M_5HFKyn} , {M_FAA}
 
 NMNAT1 [M_ATP] + [M_H] + [M_NaMN] → [M_NAAD] + [M_PPi];   {M_ATP} , {M_H} , {M_NaMN}
 
 ACMSD [M_Acms] → [M_Am6sa] + [M_CO2];   {M_Quin} , {M_Kyna} , {M_Acms}
 
 MAOA_Serotonin [M_Serotonin] + [M_H2O] + [M_O2] → [M_5HAc] + [M_H2O2] + [M_NH4];   {M_Trypta} , {M_5HKyn} , {M_Serotonin}
 
 AANAT_Serotonin [M_AcetylCoA] + [M_Serotonin] → [M_NAcSet] + [M_CoA] + [M_H];   {M_Trypta} , {M_Serotonin}
 
 KAT1_3HKyn [M_3HKyn] + [M_Ketoglutarate] → [M_Xanth] + [M_LGlu];   {M_L-Kyn} , {M_3HKyn}
 
 IDO_Serotonin [M_Serotonin] + [M_O2] → [M_F5HKyn];   {M_5HTrp} , {M_Trp} , {M_O2} , {M_Serotonin}
 
 INMT_MTrypta [M_AMet] + [M_MTrypta] → [M_AHCys] + [M_MMTrypta];   {M_Serotonin} , {M_Trypta} , {M_MTrypta}
 
 INMT_Serotonin [M_AMet] + [M_Serotonin] → [M_AHCys] + [M_NMSer];   {M_MTrypta} , {M_Trypta} , {M_Serotonin}
 
 KAT2_3HKyn [M_3HKyn] + [M_Ketoglutarate] → [M_Xanth] + [M_LGlu];   {M_L-Kyn} , {M_3HKyn}
 
 KAT3_3HKyn [M_3HKyn] + [M_Ketoglutarate] → [M_Xanth] + [M_LGlu];   {M_L-Kyn} , {M_3HKyn}
 
 KAT2_L-Kyn [M_L-Kyn] + [M_Ketoglutarate] → [M_Kyna] + [M_LGlu];   {M_3HKyn} , {M_L-Kyn}
 
 KAT3_L-Kyn [M_L-Kyn] + [M_Ketoglutarate] → [M_Kyna] + [M_LGlu];   {M_3HKyn} , {M_L-Kyn}
 
 MAOB_Serotonin [M_Serotonin] + [M_H2O] + [M_O2] → [M_5HAc] + [M_H2O2] + [M_NH4];   {M_Trypta} , {M_5HKyn} , {M_Serotonin}
 
 MAOB_Trypta [M_Trypta] + [M_H2O] + [M_O2] → [M_IndolAc] + [M_NH4] + [M_H2O2];   {M_Serotonin} , {M_Trypta}
 
 AANAT_Trypta [M_AcetylCoA] + [M_Trypta] → [M_Nactrypta] + [M_CoA] + [M_H];   {M_Serotonin} , {M_Trypta}
 
 TPH2 [M_Thbpt] + [M_Trp] + [M_O2] → [M_5HTrp] + [M_Dhbpt] + [M_H2O];   {M_O2} , {M_Thbpt} , {M_Trp}
 
 Tryptophan_Transport Slc7a8 [Trp_ex] ↔ [M_Trp];   {M_LKyn_ex} , {M_L-Kyn} , {M_Trp} , {Trp_ex}
 
 Lkynr_Transporter_Slc7a5 [M_L-Kyn] ↔ [M_LKyn_ex];   {M_Trp} , {Trp_ex} , {M_L-Kyn} , {M_LKyn_ex}
 
 Lkynr_Transporter_Slc7a8 [M_L-Kyn] ↔ [M_LKyn_ex];   {M_Trp} , {Trp_ex} , {M_L-Kyn} , {M_LKyn_ex}
 
 Cytosol Spatial dimensions: 3.0  Compartment size: 1.0
 
 M_3HAA
Compartment: Cytosol
Initial concentration: 3.29767682642125E-6
 
 M_5HFKyn
Compartment: Cytosol
Initial concentration: 2.3285262897484E-10
 
 M_5HTrp
Compartment: Cytosol
Initial concentration: 9.86485434437397E-7
 
 M_5HKyn
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_FKyn
Compartment: Cytosol
Initial concentration: 2.18400152663056E-5
 
 M_L-Kyn
Compartment: Cytosol
Initial concentration: 0.00263243682881056
 
 M_AHCys
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_Ketoglutarate
Compartment: Cytosol
Initial concentration: 0.9999999518
Constant
 
 M_L_ALA
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_AMet
Compartment: Cytosol
Initial concentration: 0.9999999518
Constant
 
 M_AA
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_Acms
Compartment: Cytosol
Initial concentration: 1.12181722190904E-5
 
 M_Dhbpt
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_Formate
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_LGlu
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_3HKyn
Compartment: Cytosol
Initial concentration: 1.1966020248522E-5
 
 M_IndolAc
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_IndolP
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_MTrypta
Compartment: Cytosol
Initial concentration: 2.5994745417821E-9
 
 M_Quin
Compartment: Cytosol
Initial concentration: 1.78449610733141E-15
 
 M_Serotonin
Compartment: Cytosol
Initial concentration: 7.76306594979262E-8
 
 M_Thbpt
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_tRNA
Compartment: Cytosol
Initial concentration: 1.0E-5
Constant
 
 M_Trp
Compartment: Cytosol
Initial concentration: 1.20064386474403E-4
 
 M_Trp_tRNA
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_Trypta
Compartment: Cytosol
Initial concentration: 3.59090204143853E-9
 
 M_AMP
Compartment: Cytosol
Initial concentration: 0.999999951844375
Constant
 
 M_ATP
Compartment: Cytosol
Initial concentration: 0.999999951844375
Constant
 
 M_CO2
Compartment: Cytosol
Initial concentration: 0.999999951844375
Constant
 
 M_H2O2
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_H2O
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_H
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_NADP
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_NADPH
Compartment: Cytosol
Initial concentration: 0.03
Constant
 
 M_NH4
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_O2
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_O2s
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_PPi
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_Cin
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_Kyna
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 Trp_ex
Compartment: Cytosol
Initial concentration: 0.005
Constant
 
 M_NaMN
Compartment: Cytosol
Initial concentration: 9.50021481464022E-16
 
 M_PRPP
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_FAA
Compartment: Cytosol
Initial concentration: 7.14152660211118E-9
 
 M_NAAD
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_Am6sa
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_5HAc
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_NAcSet
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_AcetylCoA
Compartment: Cytosol
Initial concentration: 0.999999951844375
Constant
 
 M_CoA
Compartment: Cytosol
Initial concentration: 1.0
Constant
 
 M_Xanth
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_F5HKyn
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_MMTrypta
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_NMSer
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_Nactrypta
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
 M_LKyn_ex
Compartment: Cytosol
Initial concentration: 0.0
Constant
 
Global Parameters (42)
 
 scaling
Value: 1.0
Constant
 
 KAT1_E_T
Value: 9455.1357421875
Constant
 
 KAT2_E_T
Value: 7744.3154296875
Constant
 
 KAT3_E_T
Value: 15588.2099609375
Constant
 
 KAT_Km_3HKyn
Value: 3.8
Constant
 
 KAT_Km_L-kyn
Value: 4.7
Constant
 
 AANAT_E_T
Value: 2770.9680175781
Constant
 
 AANAT_Km_Serotonin
Value: 1.35
Constant
 
 AANAT_Km_Trypta
Value: 0.88
Constant
 
 AFMID_E_T
Value: 15820.2158203125
Constant
 
 AFMID_Km_5HFKyn
Value: 0.4
Constant
 
 AFMID_Km_FKyn
Value: 0.05
Constant
 
 AFMID_Km_FAA
Value: 0.211
Constant
 
 DDC_E_T
Value: 36074.9140625
Constant
 
 DDC_Km_5htrp
Value: 0.049
Constant
 
 DDC_Km_Trp
Value: 10.0
Constant
 
 IDO_E_T
Value: 453.4833679199
Constant
 
 IDO_Km_Trp
Value: 0.045
Constant
 
 IDO_Km_5htrp
Value: 0.02
Constant
 
 IDO_Km_Serotonin
Value: 0.1
Constant
 
 IMNT_E_T
Value: 4186.5874023438
Constant
 
 IMNT_Km_Serotonin
Value: 1.38
Constant
 
 IMNT_Km_Trypta
Value: 0.27
Constant
 
 IMNT_Km_MTrypta
Value: 0.086
Constant
 
 KYNU_Km_3HKyn
Value: 0.028
Constant
 
 Transporter_E_T_Slc7a8
Value: 2226.3728027344
Constant
 
 KYNU_E_T
Value: 56601.7578125
Constant
 
 KYNU_Km_FKyn
Value: 2.2
Constant
 
 KYNU_Km_L-kyn
Value: 0.495
Constant
 
 Transporter_Km_L-kyn
Value: 0.032
Constant
 
 Transporter_Km_Trp_Slc7a8
Value: 0.0573
Constant
 
 Transporter_E_T_Slc7a5
Value: 1961.5135498047
Constant
 
 Transporter_Km_Trp_Slc7a5
Value: 0.019
Constant
 
 MAOA_E_T
Value: 137204.8125
Constant
 
 MAOB_E_T
Value: 294114.875
Constant
 
 MAO_Km_Serotonin
Value: 0.43
Constant
 
 MAO_Km_Trypta
Value: 0.033
Constant
 
 IDO_Km_O2
Value: 0.042
Constant
 
 KAT_kcat_3HKyn
Value: 1.7
Constant
 
 KAT_kcat_L-kyn
Value: 9.76
Constant
 
 Transporter_kcat_Trp
Value: 1.3
Constant
 
 Transporter_kcat_L-kyn
Value: 1.3
Constant
 
IL4I1 (4)
 
   E_T
Value: 2046.74
Constant
 
   Ka
Value: 6.5
Constant
 
   Kb
Value: 1.2
Constant
 
   kcat
Value: 1.0
Constant
 
TDO (4)
 
   E_T
Value: 943912.0
Constant
 
   Ka
Value: 0.222
Constant
 
   Kb
Value: 0.037
Constant
 
   kcat
Value: 1.4
Constant
 
DDC_Trypta (1)
 
   kcat_B
Value: 0.38
Constant
 
KYNU_L-Kyn (1)
 
   kcat_A
Value: 0.23
Constant
 
TPH1 (4)
 
   E_T
Value: 503.141
Constant
 
   Ka
Value: 0.0228
Constant
 
   Kb
Value: 0.109
Constant
 
   kcat
Value: 0.57
Constant
 
AFMID_FKyn (1)
 
   kcat_A
Value: 100.0
Constant
 
KMO (5)
 
   E_T
Value: 9766.18
Constant
 
   Ka
Value: 0.1
Constant
 
   Kb
Value: 0.071
Constant
 
   Kc
Value: 0.153
Constant
 
   kcat
Value: 2.2
Constant
 
INMT_Trypta (1)
 
   kcat_A
Value: 0.4
Constant
 
HAAO (4)
 
   E_T
Value: 10308.4
Constant
 
   Ka
Value: 0.016
Constant
 
   Kb
Value: 0.615
Constant
 
   kcat
Value: 64.0
Constant
 
KYNU_3HKyn (1)
 
   kcat_A
Value: 3.5
Constant
 
DDC_5HTrp (1)
 
   kcat_B
Value: 2.0
Constant
 
IDO_5HTrp (1)
 
   kcat
Value: 0.043
Constant
 
WARS (4)
 
   E_T
Value: 15961.5
Constant
 
   Ka
Value: 0.0074
Constant
 
   Kb
Value: 0.0011
Constant
 
   kcat
Value: 1.1
Constant
 
AFMID_5HFKyn (1)
 
   kcat_A
Value: 100.0
Constant
 
Quinolic Acid formation (spontaneous) (1)
 
   k1
Value: 2.5E-4
Constant
 
MAOA_Trypta (1)
 
   kcat_B
Value: 3.5
Constant
 
Cinnavalinate formation (3)
 
   e1
Value: 2.0
Constant
 
   e2
Value: 4.0
Constant
 
   k1
Value: 5.6667E-5
Constant
 
IDO (1)
 
   kcat
Value: 1.65
Constant
 
QPRT (4)
 
   E_T
Value: 138709.0
Constant
 
   Ka
Value: 0.022
Constant
 
   Kb
Value: 0.023
Constant
 
   kcat
Value: 0.255
Constant
 
KYNU_FKyn (1)
 
   kcat_A
Value: 0.013
Constant
 
AFMID_FAA (1)
 
   kcat_A
Value: 13.57
Constant
 
NMNAT1 (3)
 
   E_T
Value: 4658.65
Constant
 
   Km
Value: 0.0677
Constant
 
   kcat
Value: 42.9
Constant
 
ACMSD (3)
 
   E_T
Value: 48858.2
Constant
 
   Km
Value: 0.0065
Constant
 
   kcat
Value: 1.0
Constant
 
MAOA_Serotonin (1)
 
   kcat_B
Value: 18.6
Constant
 
AANAT_Serotonin (1)
 
   kcat_B
Value: 25.9
Constant
 
IDO_Serotonin (1)
 
   kcat
Value: 0.002
Constant
 
INMT_MTrypta (1)
 
   kcat_A
Value: 0.176
Constant
 
INMT_Serotonin (1)
 
   kcat_A
Value: 0.044
Constant
 
MAOB_Serotonin (1)
 
   kcat_B
Value: 18.6
Constant
 
MAOB_Trypta (1)
 
   kcat_B
Value: 3.5
Constant
 
AANAT_Trypta (1)
 
   kcat_B
Value: 25.9
Constant
 
TPH2 (4)
 
   E_T
Value: 235.128
Constant
 
   Ka
Value: 0.0403
Constant
 
   Kb
Value: 0.273
Constant
 
   kcat
Value: 0.18
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000602

Curator's comment: (updated: 18 Apr 2016 15:25:59 BST)

The steady-state metabolite concentrations and reaction relative fluxes for human liver, as shown in Figure 2C of the reference publication has been reproduced here. The simulation was checked with both Copasi and SimBiology.

Note: SimBiology does not easily export reaction fluxes. Models for the rat liver and cortex and the human brain can be produced by substituting *_E_T parameter values with values from Tables S4a and S4b of the reference publication.

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