BioModels Database logo

BioModels Database

spacer

BIOMD0000000595 - Capuani2015 - Binding of Cbl and Grb2 to EGFR (Early Activation Model - EAM)

  
 |   |   |  Send feedback
Reference Publication
Publication ID: 26264748
Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, Di Fiore PP, Sigismund S, Ciliberto A.
Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.
Nat Commun 2015; 6: 7999
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, Milan 20139, Italy.  [more]
Model
Original Model: BIOMD0000000595.origin
Submitter: Fabrizio Capuani
Submission ID: MODEL1505190000
Submission Date: 19 May 2015 12:47:02 UTC
Last Modification Date: 19 Apr 2016 21:55:15 UTC
Creation Date: 10 Feb 2016 14:20:27 UTC
Encoders:  Fabrizio Capuani
   Alastair Hume
set #1
bqbiol:hasTaxon Taxonomy Homo sapiens
set #2
bqbiol:hasProperty Human Disease Ontology cancer
set #3
bqbiol:isVersionOf Gene Ontology epidermal growth factor receptor signaling pathway
set #4
bqbiol:occursIn Brenda Tissue Ontology HeLa cell
Notes
Model
Publication ID: 26264748 Submission Date: 19 May 2015 12:47:02 UTC Last Modification Date: 19 Apr 2016 21:55:15 UTC Creation Date: 10 Feb 2016 14:20:27 UTC
Mathematical expressions
Reactions
Rc10UU has site Y1045 dephosphorylated Rc01UU has site Y1068/Y1086 dephosphorylated Rc11UU has site Y1045 dephosphorylated Rc11UU has site Y1068/Y1086 dephosphorylated
Rc11CU has site Y1068/Y1086 dephosphorylated Rc11LU has site Y1068/Y1086 dephosphorylated Rc11UG has site Y1045 dephosphorylated Rc11UL has site Y1045 dephosphorylated
Rc02UU has site Y1068/Y1086 dephosphorylated Rc02UG has site Y1068/Y1-86 dephosphorylated Rc02UL has site Y1068/Y1-86 dephosphorylated Rc12UU has site Y1045 dephosphorylated
Rc12UU has site Y1068/Y1086 dephosphorylated Rc12CU has site Y1068/Y1086 dephosphorylated Rc12LU has site Y1068/Y1086 dephosphorylated Rc12UG has site Y1045 dephosphorylated
Rc12UG has site Y1068/Y1-86 dephosphorylated Rc12UL has site Y1045 dephosphorylated Rc12UL has site Y1068/Y1-86 dephosphorylated Rc12CG has site Y1068/Y1-86 dephosphorylated
Rc12CC has site Y1068/Y1-86 dephosphorylated Rc12LG has site Y1068/Y1-86 dephosphorylated RcL10UU has site Y1045 dephosphorylated RcL01UU has site Y1068/Y1086 dephosphorylated
RcL11UU has site Y1045 dephosphorylated RcL11UU has site Y1068/Y1086 dephosphorylated RcL11CU has site Y1068/Y1086 dephosphorylated RcL11LU has site Y1068/Y1086 dephosphorylated
RcL11UG has site Y1045 dephosphorylated RcL11UL has site Y1045 dephosphorylated RcL02UU has site Y1068/Y1086 dephosphorylated RcL02UG has site Y1068/Y1-86 dephosphorylated
RcL02UL has site Y1068/Y1-86 dephosphorylated RcL12UU has site Y1045 dephosphorylated RcL12UU has site Y1068/Y1086 dephosphorylated RcL12CU has site Y1068/Y1086 dephosphorylated
RcL12LU has site Y1068/Y1086 dephosphorylated RcL12UG has site Y1045 dephosphorylated RcL12UG has site Y1068/Y1-86 dephosphorylated RcL12UL has site Y1045 dephosphorylated
RcL12UL has site Y1068/Y1-86 dephosphorylated RcL12CG has site Y1068/Y1-86 dephosphorylated RcL12CC has site Y1068/Y1-86 dephosphorylated RcL12LG has site Y1068/Y1-86 dephosphorylated
R10UU has site Y1045 dephosphorylated R01UU has site Y1068/Y1086 dephosphorylated R11UU has site Y1045 dephosphorylated R11UU has site Y1068/Y1086 dephosphorylated
R11CU has site Y1068/Y1086 dephosphorylated R11LU has site Y1068/Y1086 dephosphorylated R11UG has site Y1045 dephosphorylated R11UL has site Y1045 dephosphorylated
R02UU has site Y1068/Y1086 dephosphorylated R02UG has site Y1068/Y1-86 dephosphorylated R02UL has site Y1068/Y1-86 dephosphorylated R12UU has site Y1045 dephosphorylated
R12UU has site Y1068/Y1086 dephosphorylated R12CU has site Y1068/Y1086 dephosphorylated R12LU has site Y1068/Y1086 dephosphorylated R12UG has site Y1045 dephosphorylated
R12UG has site Y1068/Y1-86 dephosphorylated R12UL has site Y1045 dephosphorylated R12UL has site Y1068/Y1-86 dephosphorylated R12CG has site Y1068/Y1-86 dephosphorylated
R12CC has site Y1068/Y1-86 dephosphorylated R12LG has site Y1068/Y1-86 dephosphorylated RL10UU has site Y1045 dephosphorylated RL01UU has site Y1068/Y1086 dephosphorylated
RL11UU has site Y1045 dephosphorylated RL11UU has site Y1068/Y1086 dephosphorylated RL11CU has site Y1068/Y1086 dephosphorylated RL11LU has site Y1068/Y1086 dephosphorylated
RL11UG has site Y1045 dephosphorylated RL11UL has site Y1045 dephosphorylated RL02UU has site Y1068/Y1086 dephosphorylated RL02UG has site Y1068/Y1-86 dephosphorylated
RL02UL has site Y1068/Y1-86 dephosphorylated RL12UU has site Y1045 dephosphorylated RL12UU has site Y1068/Y1086 dephosphorylated RL12CU has site Y1068/Y1086 dephosphorylated
RL12LU has site Y1068/Y1086 dephosphorylated RL12UG has site Y1045 dephosphorylated RL12UG has site Y1068/Y1-86 dephosphorylated RL12UL has site Y1045 dephosphorylated
RL12UL has site Y1068/Y1-86 dephosphorylated RL12CG has site Y1068/Y1-86 dephosphorylated RL12CC has site Y1068/Y1-86 dephosphorylated RL12LG has site Y1068/Y1-86 dephosphorylated
Di10UU has site Y1045 dephosphorylated Di01UU has site Y1068/Y1086 dephosphorylated Di11UU has site Y1045 dephosphorylated Di11UU has site Y1068/Y1086 dephosphorylated
Di11CU has site Y1068/Y1086 dephosphorylated Di11LU has site Y1068/Y1086 dephosphorylated Di11UG has site Y1045 dephosphorylated Di11UL has site Y1045 dephosphorylated
Di02UU has site Y1068/Y1086 dephosphorylated Di02UG has site Y1068/Y1-86 dephosphorylated Di02UL has site Y1068/Y1-86 dephosphorylated Di12UU has site Y1045 dephosphorylated
Di12UU has site Y1068/Y1086 dephosphorylated Di12CU has site Y1068/Y1086 dephosphorylated Di12LU has site Y1068/Y1086 dephosphorylated Di12UG has site Y1045 dephosphorylated
Di12UG has site Y1068/Y1-86 dephosphorylated Di12UL has site Y1045 dephosphorylated Di12UL has site Y1068/Y1-86 dephosphorylated Di12CG has site Y1068/Y1-86 dephosphorylated
Di12CC has site Y1068/Y1-86 dephosphorylated Di12LG has site Y1068/Y1-86 dephosphorylated Da10UU has site Y1045 dephosphorylated Da01UU has site Y1068/Y1086 dephosphorylated
Da11UU has site Y1045 dephosphorylated Da11UU has site Y1068/Y1086 dephosphorylated Da11CU has site Y1068/Y1086 dephosphorylated Da11LU has site Y1068/Y1086 dephosphorylated
Da11UG has site Y1045 dephosphorylated Da11UL has site Y1045 dephosphorylated Da02UU has site Y1068/Y1086 dephosphorylated Da02UG has site Y1068/Y1-86 dephosphorylated
Da02UL has site Y1068/Y1-86 dephosphorylated Da12UU has site Y1045 dephosphorylated Da12UU has site Y1068/Y1086 dephosphorylated Da12CU has site Y1068/Y1086 dephosphorylated
Da12LU has site Y1068/Y1086 dephosphorylated Da12UG has site Y1045 dephosphorylated Da12UG has site Y1068/Y1-86 dephosphorylated Da12UL has site Y1045 dephosphorylated
Da12UL has site Y1068/Y1-86 dephosphorylated Da12CG has site Y1068/Y1-86 dephosphorylated Da12CC has site Y1068/Y1-86 dephosphorylated Da12LG has site Y1068/Y1-86 dephosphorylated
DiL10UU has site Y1045 dephosphorylated DiL01UU has site Y1068/Y1086 dephosphorylated DiL11UU has site Y1045 dephosphorylated DiL11UU has site Y1068/Y1086 dephosphorylated
DiL11CU has site Y1068/Y1086 dephosphorylated DiL11LU has site Y1068/Y1086 dephosphorylated DiL11UG has site Y1045 dephosphorylated DiL11UL has site Y1045 dephosphorylated
DiL02UU has site Y1068/Y1086 dephosphorylated DiL02UG has site Y1068/Y1-86 dephosphorylated DiL02UL has site Y1068/Y1-86 dephosphorylated DiL12UU has site Y1045 dephosphorylated
DiL12UU has site Y1068/Y1086 dephosphorylated DiL12CU has site Y1068/Y1086 dephosphorylated DiL12LU has site Y1068/Y1086 dephosphorylated DiL12UG has site Y1045 dephosphorylated
DiL12UG has site Y1068/Y1-86 dephosphorylated DiL12UL has site Y1045 dephosphorylated DiL12UL has site Y1068/Y1-86 dephosphorylated DiL12CG has site Y1068/Y1-86 dephosphorylated
DiL12CC has site Y1068/Y1-86 dephosphorylated DiL12LG has site Y1068/Y1-86 dephosphorylated DaL10UU has site Y1045 dephosphorylated DaL01UU has site Y1068/Y1086 dephosphorylated
DaL11UU has site Y1045 dephosphorylated DaL11UU has site Y1068/Y1086 dephosphorylated DaL11CU has site Y1068/Y1086 dephosphorylated DaL11LU has site Y1068/Y1086 dephosphorylated
DaL11UG has site Y1045 dephosphorylated DaL11UL has site Y1045 dephosphorylated DaL02UU has site Y1068/Y1086 dephosphorylated DaL02UG has site Y1068/Y1-86 dephosphorylated
DaL02UL has site Y1068/Y1-86 dephosphorylated DaL12UU has site Y1045 dephosphorylated DaL12UU has site Y1068/Y1086 dephosphorylated DaL12CU has site Y1068/Y1086 dephosphorylated
DaL12LU has site Y1068/Y1086 dephosphorylated DaL12UG has site Y1045 dephosphorylated DaL12UG has site Y1068/Y1-86 dephosphorylated DaL12UL has site Y1045 dephosphorylated
DaL12UL has site Y1068/Y1-86 dephosphorylated DaL12CG has site Y1068/Y1-86 dephosphorylated DaL12CC has site Y1068/Y1-86 dephosphorylated DaL12LG has site Y1068/Y1-86 dephosphorylated
Da00UU has site Y1045 phosphorylated Da00UU has site Y1068/Y1086 phosphorylated Da10UU has site Y1068/Y1086 phosphorylated Da10CU has site Y1068/Y1086 phosphorylated
Da10LU has site Y1068/Y1086 phosphorylated Da01UU has site Y1045 phosphorylated Da01UU has site Y1068/Y1086 phosphorylated Da01UG has site Y1045 phosphorylated
Da01UG has site Y1068/Y1086 phosphorylated Da01UL has site Y1045 phosphorylated Da01UL has site Y1068/Y1086 phosphorylated Da11UU has site Y1068/Y1086 phosphorylated
Da11CU has site Y1068/Y1086 phosphorylated Da11LU has site Y1068/Y1086 phosphorylated Da11UG has site Y1068/Y1086 phosphorylated Da11UL has site Y1068/Y1086 phosphorylated
Da11CG has site Y1068/Y1086 phosphorylated Da11CC has site Y1068/Y1086 phosphorylated Da11LG has site Y1068/Y1086 phosphorylated Da02UU has site Y1045 phosphorylated
Da02UG has site Y1045 phosphorylated Da02UL has site Y1045 phosphorylated DaL00UU has site Y1045 phosphorylated DaL00UU has site Y1068/Y1086 phosphorylated
DaL10UU has site Y1068/Y1086 phosphorylated DaL10CU has site Y1068/Y1086 phosphorylated DaL10LU has site Y1068/Y1086 phosphorylated DaL01UU has site Y1045 phosphorylated
DaL01UU has site Y1068/Y1086 phosphorylated DaL01UG has site Y1045 phosphorylated DaL01UG has site Y1068/Y1086 phosphorylated DaL01UL has site Y1045 phosphorylated
DaL01UL has site Y1068/Y1086 phosphorylated DaL11UU has site Y1068/Y1086 phosphorylated DaL11CU has site Y1068/Y1086 phosphorylated DaL11LU has site Y1068/Y1086 phosphorylated
DaL11UG has site Y1068/Y1086 phosphorylated DaL11UL has site Y1068/Y1086 phosphorylated DaL11CG has site Y1068/Y1086 phosphorylated DaL11CC has site Y1068/Y1086 phosphorylated
DaL11LG has site Y1068/Y1086 phosphorylated DaL02UU has site Y1045 phosphorylated DaL02UG has site Y1045 phosphorylated DaL02UL has site Y1045 phosphorylated
Cbl and Grb2 bind yielding CG CG dissociates to Cbl and Grb2 Cbl and Rc10UU bind yielding Rc10CU Rc10CU dissociates to Cbl and Rc10UU
CG and Rc10UU bind yielding Rc10LU Rc10LU dissociates to CG and Rc10UU Grb2 and Rc10CU bind yielding Rc10LU Rc10LU dissociates to Grb2 and Rc10CU
Grb2 and Rc01UU bind yielding Rc01UG Rc01UG dissociates to Grb2 and Rc01UU CG and Rc01UU bind yielding Rc01UL Rc01UL dissociates to CG and Rc01UU
Cbl and Rc01UG bind yielding Rc01UL Rc01UL dissociates to Cbl and Rc01UG Cbl and Rc11UU bind yielding Rc11CU Rc11CU dissociates to Cbl and Rc11UU
CG and Rc11UU bind yielding Rc11LU Rc11LU dissociates to CG and Rc11UU Grb2 and Rc11UU bind yielding Rc11UG Rc11UG dissociates to Grb2 and Rc11UU
CG and Rc11UU bind yielding Rc11UL Rc11UL dissociates to CG and Rc11UU Grb2 and Rc11CU bind yielding Rc11LU Rc11LU dissociates to Grb2 and Rc11CU
Grb2 and Rc11CU bind yielding Rc11CG Rc11CG dissociates to Grb2 and Rc11CU Grb2 and Rc11LU bind yielding Rc11LG Rc11LG dissociates to Grb2 and Rc11LU
Rc11LU transforms in (singly-bound -> doubly-bound) Rc11CC Rc11CC tranforms in (doubly-bound -> singly-bound) Rc11LU Cbl and Rc11UG bind yielding Rc11CG Rc11CG dissociates to Cbl and Rc11UG
CG and Rc11UG bind yielding Rc11LG Rc11LG dissociates to CG and Rc11UG Cbl and Rc11UG bind yielding Rc11UL Rc11UL dissociates to Cbl and Rc11UG
Rc11UL transforms in (singly-bound -> doubly-bound) Rc11CC Rc11CC tranforms in (doubly-bound -> singly-bound) Rc11UL Rc11CG transforms in (Cbl bind Grb2 directly) Rc11CC Rc11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Rc11CG
Grb2 and Rc11CG bind yielding Rc11LG Rc11LG dissociates to Grb2 and Rc11CG Grb2 and Rc02UU bind yielding Rc02UG Rc02UG dissociates to Grb2 and Rc02UU
CG and Rc02UU bind yielding Rc02UL Rc02UL dissociates to CG and Rc02UU Cbl and Rc02UG bind yielding Rc02UL Rc02UL dissociates to Cbl and Rc02UG
Cbl and Rc12UU bind yielding Rc12CU Rc12CU dissociates to Cbl and Rc12UU CG and Rc12UU bind yielding Rc12LU Rc12LU dissociates to CG and Rc12UU
Grb2 and Rc12UU bind yielding Rc12UG Rc12UG dissociates to Grb2 and Rc12UU CG and Rc12UU bind yielding Rc12UL Rc12UL dissociates to CG and Rc12UU
Grb2 and Rc12CU bind yielding Rc12LU Rc12LU dissociates to Grb2 and Rc12CU Grb2 and Rc12CU bind yielding Rc12CG Rc12CG dissociates to Grb2 and Rc12CU
Grb2 and Rc12LU bind yielding Rc12LG Rc12LG dissociates to Grb2 and Rc12LU Rc12LU transforms in (singly-bound -> doubly-bound) Rc12CC Rc12CC tranforms in (doubly-bound -> singly-bound) Rc12LU
Cbl and Rc12UG bind yielding Rc12CG Rc12CG dissociates to Cbl and Rc12UG CG and Rc12UG bind yielding Rc12LG Rc12LG dissociates to CG and Rc12UG
Cbl and Rc12UG bind yielding Rc12UL Rc12UL dissociates to Cbl and Rc12UG Rc12UL transforms in (singly-bound -> doubly-bound) Rc12CC Rc12CC tranforms in (doubly-bound -> singly-bound) Rc12UL
Rc12CG transforms in (Cbl bind Grb2 directly) Rc12CC Rc12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Rc12CG Grb2 and Rc12CG bind yielding Rc12LG Rc12LG dissociates to Grb2 and Rc12CG
Cbl and RcL10UU bind yielding RcL10CU RcL10CU dissociates to Cbl and RcL10UU CG and RcL10UU bind yielding RcL10LU RcL10LU dissociates to CG and RcL10UU
Grb2 and RcL10CU bind yielding RcL10LU RcL10LU dissociates to Grb2 and RcL10CU Grb2 and RcL01UU bind yielding RcL01UG RcL01UG dissociates to Grb2 and RcL01UU
CG and RcL01UU bind yielding RcL01UL RcL01UL dissociates to CG and RcL01UU Cbl and RcL01UG bind yielding RcL01UL RcL01UL dissociates to Cbl and RcL01UG
Cbl and RcL11UU bind yielding RcL11CU RcL11CU dissociates to Cbl and RcL11UU CG and RcL11UU bind yielding RcL11LU RcL11LU dissociates to CG and RcL11UU
Grb2 and RcL11UU bind yielding RcL11UG RcL11UG dissociates to Grb2 and RcL11UU CG and RcL11UU bind yielding RcL11UL RcL11UL dissociates to CG and RcL11UU
Grb2 and RcL11CU bind yielding RcL11LU RcL11LU dissociates to Grb2 and RcL11CU Grb2 and RcL11CU bind yielding RcL11CG RcL11CG dissociates to Grb2 and RcL11CU
Grb2 and RcL11LU bind yielding RcL11LG RcL11LG dissociates to Grb2 and RcL11LU RcL11LU transforms in (singly-bound -> doubly-bound) RcL11CC RcL11CC tranforms in (doubly-bound -> singly-bound) RcL11LU
Cbl and RcL11UG bind yielding RcL11CG RcL11CG dissociates to Cbl and RcL11UG CG and RcL11UG bind yielding RcL11LG RcL11LG dissociates to CG and RcL11UG
Cbl and RcL11UG bind yielding RcL11UL RcL11UL dissociates to Cbl and RcL11UG RcL11UL transforms in (singly-bound -> doubly-bound) RcL11CC RcL11CC tranforms in (doubly-bound -> singly-bound) RcL11UL
RcL11CG transforms in (Cbl bind Grb2 directly) RcL11CC RcL11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) RcL11CG Grb2 and RcL11CG bind yielding RcL11LG RcL11LG dissociates to Grb2 and RcL11CG
Grb2 and RcL02UU bind yielding RcL02UG RcL02UG dissociates to Grb2 and RcL02UU CG and RcL02UU bind yielding RcL02UL RcL02UL dissociates to CG and RcL02UU
Cbl and RcL02UG bind yielding RcL02UL RcL02UL dissociates to Cbl and RcL02UG Cbl and RcL12UU bind yielding RcL12CU RcL12CU dissociates to Cbl and RcL12UU
CG and RcL12UU bind yielding RcL12LU RcL12LU dissociates to CG and RcL12UU Grb2 and RcL12UU bind yielding RcL12UG RcL12UG dissociates to Grb2 and RcL12UU
CG and RcL12UU bind yielding RcL12UL RcL12UL dissociates to CG and RcL12UU Grb2 and RcL12CU bind yielding RcL12LU RcL12LU dissociates to Grb2 and RcL12CU
Grb2 and RcL12CU bind yielding RcL12CG RcL12CG dissociates to Grb2 and RcL12CU Grb2 and RcL12LU bind yielding RcL12LG RcL12LG dissociates to Grb2 and RcL12LU
RcL12LU transforms in (singly-bound -> doubly-bound) RcL12CC RcL12CC tranforms in (doubly-bound -> singly-bound) RcL12LU Cbl and RcL12UG bind yielding RcL12CG RcL12CG dissociates to Cbl and RcL12UG
CG and RcL12UG bind yielding RcL12LG RcL12LG dissociates to CG and RcL12UG Cbl and RcL12UG bind yielding RcL12UL RcL12UL dissociates to Cbl and RcL12UG
RcL12UL transforms in (singly-bound -> doubly-bound) RcL12CC RcL12CC tranforms in (doubly-bound -> singly-bound) RcL12UL RcL12CG transforms in (Cbl bind Grb2 directly) RcL12CC RcL12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) RcL12CG
Grb2 and RcL12CG bind yielding RcL12LG RcL12LG dissociates to Grb2 and RcL12CG Cbl and R10UU bind yielding R10CU R10CU dissociates to Cbl and R10UU
CG and R10UU bind yielding R10LU R10LU dissociates to CG and R10UU Grb2 and R10CU bind yielding R10LU R10LU dissociates to Grb2 and R10CU
Grb2 and R01UU bind yielding R01UG R01UG dissociates to Grb2 and R01UU CG and R01UU bind yielding R01UL R01UL dissociates to CG and R01UU
Cbl and R01UG bind yielding R01UL R01UL dissociates to Cbl and R01UG Cbl and R11UU bind yielding R11CU R11CU dissociates to Cbl and R11UU
CG and R11UU bind yielding R11LU R11LU dissociates to CG and R11UU Grb2 and R11UU bind yielding R11UG R11UG dissociates to Grb2 and R11UU
CG and R11UU bind yielding R11UL R11UL dissociates to CG and R11UU Grb2 and R11CU bind yielding R11LU R11LU dissociates to Grb2 and R11CU
Grb2 and R11CU bind yielding R11CG R11CG dissociates to Grb2 and R11CU Grb2 and R11LU bind yielding R11LG R11LG dissociates to Grb2 and R11LU
R11LU transforms in (singly-bound -> doubly-bound) R11CC R11CC tranforms in (doubly-bound -> singly-bound) R11LU Cbl and R11UG bind yielding R11CG R11CG dissociates to Cbl and R11UG
CG and R11UG bind yielding R11LG R11LG dissociates to CG and R11UG Cbl and R11UG bind yielding R11UL R11UL dissociates to Cbl and R11UG
R11UL transforms in (singly-bound -> doubly-bound) R11CC R11CC tranforms in (doubly-bound -> singly-bound) R11UL R11CG transforms in (Cbl bind Grb2 directly) R11CC R11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) R11CG
Grb2 and R11CG bind yielding R11LG R11LG dissociates to Grb2 and R11CG Grb2 and R02UU bind yielding R02UG R02UG dissociates to Grb2 and R02UU
CG and R02UU bind yielding R02UL R02UL dissociates to CG and R02UU Cbl and R02UG bind yielding R02UL R02UL dissociates to Cbl and R02UG
Cbl and R12UU bind yielding R12CU R12CU dissociates to Cbl and R12UU CG and R12UU bind yielding R12LU R12LU dissociates to CG and R12UU
Grb2 and R12UU bind yielding R12UG R12UG dissociates to Grb2 and R12UU CG and R12UU bind yielding R12UL R12UL dissociates to CG and R12UU
Grb2 and R12CU bind yielding R12LU R12LU dissociates to Grb2 and R12CU Grb2 and R12CU bind yielding R12CG R12CG dissociates to Grb2 and R12CU
Grb2 and R12LU bind yielding R12LG R12LG dissociates to Grb2 and R12LU R12LU transforms in (singly-bound -> doubly-bound) R12CC R12CC tranforms in (doubly-bound -> singly-bound) R12LU
Cbl and R12UG bind yielding R12CG R12CG dissociates to Cbl and R12UG CG and R12UG bind yielding R12LG R12LG dissociates to CG and R12UG
Cbl and R12UG bind yielding R12UL R12UL dissociates to Cbl and R12UG R12UL transforms in (singly-bound -> doubly-bound) R12CC R12CC tranforms in (doubly-bound -> singly-bound) R12UL
R12CG transforms in (Cbl bind Grb2 directly) R12CC R12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) R12CG Grb2 and R12CG bind yielding R12LG R12LG dissociates to Grb2 and R12CG
Cbl and RL10UU bind yielding RL10CU RL10CU dissociates to Cbl and RL10UU CG and RL10UU bind yielding RL10LU RL10LU dissociates to CG and RL10UU
Grb2 and RL10CU bind yielding RL10LU RL10LU dissociates to Grb2 and RL10CU Grb2 and RL01UU bind yielding RL01UG RL01UG dissociates to Grb2 and RL01UU
CG and RL01UU bind yielding RL01UL RL01UL dissociates to CG and RL01UU Cbl and RL01UG bind yielding RL01UL RL01UL dissociates to Cbl and RL01UG
Cbl and RL11UU bind yielding RL11CU RL11CU dissociates to Cbl and RL11UU CG and RL11UU bind yielding RL11LU RL11LU dissociates to CG and RL11UU
Grb2 and RL11UU bind yielding RL11UG RL11UG dissociates to Grb2 and RL11UU CG and RL11UU bind yielding RL11UL RL11UL dissociates to CG and RL11UU
Grb2 and RL11CU bind yielding RL11LU RL11LU dissociates to Grb2 and RL11CU Grb2 and RL11CU bind yielding RL11CG RL11CG dissociates to Grb2 and RL11CU
Grb2 and RL11LU bind yielding RL11LG RL11LG dissociates to Grb2 and RL11LU RL11LU transforms in (singly-bound -> doubly-bound) RL11CC RL11CC tranforms in (doubly-bound -> singly-bound) RL11LU
Cbl and RL11UG bind yielding RL11CG RL11CG dissociates to Cbl and RL11UG CG and RL11UG bind yielding RL11LG RL11LG dissociates to CG and RL11UG
Cbl and RL11UG bind yielding RL11UL RL11UL dissociates to Cbl and RL11UG RL11UL transforms in (singly-bound -> doubly-bound) RL11CC RL11CC tranforms in (doubly-bound -> singly-bound) RL11UL
RL11CG transforms in (Cbl bind Grb2 directly) RL11CC RL11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) RL11CG Grb2 and RL11CG bind yielding RL11LG RL11LG dissociates to Grb2 and RL11CG
Grb2 and RL02UU bind yielding RL02UG RL02UG dissociates to Grb2 and RL02UU CG and RL02UU bind yielding RL02UL RL02UL dissociates to CG and RL02UU
Cbl and RL02UG bind yielding RL02UL RL02UL dissociates to Cbl and RL02UG Cbl and RL12UU bind yielding RL12CU RL12CU dissociates to Cbl and RL12UU
CG and RL12UU bind yielding RL12LU RL12LU dissociates to CG and RL12UU Grb2 and RL12UU bind yielding RL12UG RL12UG dissociates to Grb2 and RL12UU
CG and RL12UU bind yielding RL12UL RL12UL dissociates to CG and RL12UU Grb2 and RL12CU bind yielding RL12LU RL12LU dissociates to Grb2 and RL12CU
Grb2 and RL12CU bind yielding RL12CG RL12CG dissociates to Grb2 and RL12CU Grb2 and RL12LU bind yielding RL12LG RL12LG dissociates to Grb2 and RL12LU
RL12LU transforms in (singly-bound -> doubly-bound) RL12CC RL12CC tranforms in (doubly-bound -> singly-bound) RL12LU Cbl and RL12UG bind yielding RL12CG RL12CG dissociates to Cbl and RL12UG
CG and RL12UG bind yielding RL12LG RL12LG dissociates to CG and RL12UG Cbl and RL12UG bind yielding RL12UL RL12UL dissociates to Cbl and RL12UG
RL12UL transforms in (singly-bound -> doubly-bound) RL12CC RL12CC tranforms in (doubly-bound -> singly-bound) RL12UL RL12CG transforms in (Cbl bind Grb2 directly) RL12CC RL12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) RL12CG
Grb2 and RL12CG bind yielding RL12LG RL12LG dissociates to Grb2 and RL12CG Cbl and Di10UU bind yielding Di10CU Di10CU dissociates to Cbl and Di10UU
CG and Di10UU bind yielding Di10LU Di10LU dissociates to CG and Di10UU Grb2 and Di10CU bind yielding Di10LU Di10LU dissociates to Grb2 and Di10CU
Grb2 and Di01UU bind yielding Di01UG Di01UG dissociates to Grb2 and Di01UU CG and Di01UU bind yielding Di01UL Di01UL dissociates to CG and Di01UU
Cbl and Di01UG bind yielding Di01UL Di01UL dissociates to Cbl and Di01UG Cbl and Di11UU bind yielding Di11CU Di11CU dissociates to Cbl and Di11UU
CG and Di11UU bind yielding Di11LU Di11LU dissociates to CG and Di11UU Grb2 and Di11UU bind yielding Di11UG Di11UG dissociates to Grb2 and Di11UU
CG and Di11UU bind yielding Di11UL Di11UL dissociates to CG and Di11UU Grb2 and Di11CU bind yielding Di11LU Di11LU dissociates to Grb2 and Di11CU
Grb2 and Di11CU bind yielding Di11CG Di11CG dissociates to Grb2 and Di11CU Grb2 and Di11LU bind yielding Di11LG Di11LG dissociates to Grb2 and Di11LU
Di11LU transforms in (singly-bound -> doubly-bound) Di11CC Di11CC tranforms in (doubly-bound -> singly-bound) Di11LU Cbl and Di11UG bind yielding Di11CG Di11CG dissociates to Cbl and Di11UG
CG and Di11UG bind yielding Di11LG Di11LG dissociates to CG and Di11UG Cbl and Di11UG bind yielding Di11UL Di11UL dissociates to Cbl and Di11UG
Di11UL transforms in (singly-bound -> doubly-bound) Di11CC Di11CC tranforms in (doubly-bound -> singly-bound) Di11UL Di11CG transforms in (Cbl bind Grb2 directly) Di11CC Di11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Di11CG
Grb2 and Di11CG bind yielding Di11LG Di11LG dissociates to Grb2 and Di11CG Grb2 and Di02UU bind yielding Di02UG Di02UG dissociates to Grb2 and Di02UU
CG and Di02UU bind yielding Di02UL Di02UL dissociates to CG and Di02UU Cbl and Di02UG bind yielding Di02UL Di02UL dissociates to Cbl and Di02UG
Cbl and Di12UU bind yielding Di12CU Di12CU dissociates to Cbl and Di12UU CG and Di12UU bind yielding Di12LU Di12LU dissociates to CG and Di12UU
Grb2 and Di12UU bind yielding Di12UG Di12UG dissociates to Grb2 and Di12UU CG and Di12UU bind yielding Di12UL Di12UL dissociates to CG and Di12UU
Grb2 and Di12CU bind yielding Di12LU Di12LU dissociates to Grb2 and Di12CU Grb2 and Di12CU bind yielding Di12CG Di12CG dissociates to Grb2 and Di12CU
Grb2 and Di12LU bind yielding Di12LG Di12LG dissociates to Grb2 and Di12LU Di12LU transforms in (singly-bound -> doubly-bound) Di12CC Di12CC tranforms in (doubly-bound -> singly-bound) Di12LU
Cbl and Di12UG bind yielding Di12CG Di12CG dissociates to Cbl and Di12UG CG and Di12UG bind yielding Di12LG Di12LG dissociates to CG and Di12UG
Cbl and Di12UG bind yielding Di12UL Di12UL dissociates to Cbl and Di12UG Di12UL transforms in (singly-bound -> doubly-bound) Di12CC Di12CC tranforms in (doubly-bound -> singly-bound) Di12UL
Di12CG transforms in (Cbl bind Grb2 directly) Di12CC Di12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Di12CG Grb2 and Di12CG bind yielding Di12LG Di12LG dissociates to Grb2 and Di12CG
Cbl and Da10UU bind yielding Da10CU Da10CU dissociates to Cbl and Da10UU CG and Da10UU bind yielding Da10LU Da10LU dissociates to CG and Da10UU
Grb2 and Da10CU bind yielding Da10LU Da10LU dissociates to Grb2 and Da10CU Grb2 and Da01UU bind yielding Da01UG Da01UG dissociates to Grb2 and Da01UU
CG and Da01UU bind yielding Da01UL Da01UL dissociates to CG and Da01UU Cbl and Da01UG bind yielding Da01UL Da01UL dissociates to Cbl and Da01UG
Cbl and Da11UU bind yielding Da11CU Da11CU dissociates to Cbl and Da11UU CG and Da11UU bind yielding Da11LU Da11LU dissociates to CG and Da11UU
Grb2 and Da11UU bind yielding Da11UG Da11UG dissociates to Grb2 and Da11UU CG and Da11UU bind yielding Da11UL Da11UL dissociates to CG and Da11UU
Grb2 and Da11CU bind yielding Da11LU Da11LU dissociates to Grb2 and Da11CU Grb2 and Da11CU bind yielding Da11CG Da11CG dissociates to Grb2 and Da11CU
Grb2 and Da11LU bind yielding Da11LG Da11LG dissociates to Grb2 and Da11LU Da11LU transforms in (singly-bound -> doubly-bound) Da11CC Da11CC tranforms in (doubly-bound -> singly-bound) Da11LU
Cbl and Da11UG bind yielding Da11CG Da11CG dissociates to Cbl and Da11UG CG and Da11UG bind yielding Da11LG Da11LG dissociates to CG and Da11UG
Cbl and Da11UG bind yielding Da11UL Da11UL dissociates to Cbl and Da11UG Da11UL transforms in (singly-bound -> doubly-bound) Da11CC Da11CC tranforms in (doubly-bound -> singly-bound) Da11UL
Da11CG transforms in (Cbl bind Grb2 directly) Da11CC Da11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Da11CG Grb2 and Da11CG bind yielding Da11LG Da11LG dissociates to Grb2 and Da11CG
Grb2 and Da02UU bind yielding Da02UG Da02UG dissociates to Grb2 and Da02UU CG and Da02UU bind yielding Da02UL Da02UL dissociates to CG and Da02UU
Cbl and Da02UG bind yielding Da02UL Da02UL dissociates to Cbl and Da02UG Cbl and Da12UU bind yielding Da12CU Da12CU dissociates to Cbl and Da12UU
CG and Da12UU bind yielding Da12LU Da12LU dissociates to CG and Da12UU Grb2 and Da12UU bind yielding Da12UG Da12UG dissociates to Grb2 and Da12UU
CG and Da12UU bind yielding Da12UL Da12UL dissociates to CG and Da12UU Grb2 and Da12CU bind yielding Da12LU Da12LU dissociates to Grb2 and Da12CU
Grb2 and Da12CU bind yielding Da12CG Da12CG dissociates to Grb2 and Da12CU Grb2 and Da12LU bind yielding Da12LG Da12LG dissociates to Grb2 and Da12LU
Da12LU transforms in (singly-bound -> doubly-bound) Da12CC Da12CC tranforms in (doubly-bound -> singly-bound) Da12LU Cbl and Da12UG bind yielding Da12CG Da12CG dissociates to Cbl and Da12UG
CG and Da12UG bind yielding Da12LG Da12LG dissociates to CG and Da12UG Cbl and Da12UG bind yielding Da12UL Da12UL dissociates to Cbl and Da12UG
Da12UL transforms in (singly-bound -> doubly-bound) Da12CC Da12CC tranforms in (doubly-bound -> singly-bound) Da12UL Da12CG transforms in (Cbl bind Grb2 directly) Da12CC Da12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Da12CG
Grb2 and Da12CG bind yielding Da12LG Da12LG dissociates to Grb2 and Da12CG Cbl and DiL10UU bind yielding DiL10CU DiL10CU dissociates to Cbl and DiL10UU
CG and DiL10UU bind yielding DiL10LU DiL10LU dissociates to CG and DiL10UU Grb2 and DiL10CU bind yielding DiL10LU DiL10LU dissociates to Grb2 and DiL10CU
Grb2 and DiL01UU bind yielding DiL01UG DiL01UG dissociates to Grb2 and DiL01UU CG and DiL01UU bind yielding DiL01UL DiL01UL dissociates to CG and DiL01UU
Cbl and DiL01UG bind yielding DiL01UL DiL01UL dissociates to Cbl and DiL01UG Cbl and DiL11UU bind yielding DiL11CU DiL11CU dissociates to Cbl and DiL11UU
CG and DiL11UU bind yielding DiL11LU DiL11LU dissociates to CG and DiL11UU Grb2 and DiL11UU bind yielding DiL11UG DiL11UG dissociates to Grb2 and DiL11UU
CG and DiL11UU bind yielding DiL11UL DiL11UL dissociates to CG and DiL11UU Grb2 and DiL11CU bind yielding DiL11LU DiL11LU dissociates to Grb2 and DiL11CU
Grb2 and DiL11CU bind yielding DiL11CG DiL11CG dissociates to Grb2 and DiL11CU Grb2 and DiL11LU bind yielding DiL11LG DiL11LG dissociates to Grb2 and DiL11LU
DiL11LU transforms in (singly-bound -> doubly-bound) DiL11CC DiL11CC tranforms in (doubly-bound -> singly-bound) DiL11LU Cbl and DiL11UG bind yielding DiL11CG DiL11CG dissociates to Cbl and DiL11UG
CG and DiL11UG bind yielding DiL11LG DiL11LG dissociates to CG and DiL11UG Cbl and DiL11UG bind yielding DiL11UL DiL11UL dissociates to Cbl and DiL11UG
DiL11UL transforms in (singly-bound -> doubly-bound) DiL11CC DiL11CC tranforms in (doubly-bound -> singly-bound) DiL11UL DiL11CG transforms in (Cbl bind Grb2 directly) DiL11CC DiL11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) DiL11CG
Grb2 and DiL11CG bind yielding DiL11LG DiL11LG dissociates to Grb2 and DiL11CG Grb2 and DiL02UU bind yielding DiL02UG DiL02UG dissociates to Grb2 and DiL02UU
CG and DiL02UU bind yielding DiL02UL DiL02UL dissociates to CG and DiL02UU Cbl and DiL02UG bind yielding DiL02UL DiL02UL dissociates to Cbl and DiL02UG
Cbl and DiL12UU bind yielding DiL12CU DiL12CU dissociates to Cbl and DiL12UU CG and DiL12UU bind yielding DiL12LU DiL12LU dissociates to CG and DiL12UU
Grb2 and DiL12UU bind yielding DiL12UG DiL12UG dissociates to Grb2 and DiL12UU CG and DiL12UU bind yielding DiL12UL DiL12UL dissociates to CG and DiL12UU
Grb2 and DiL12CU bind yielding DiL12LU DiL12LU dissociates to Grb2 and DiL12CU Grb2 and DiL12CU bind yielding DiL12CG DiL12CG dissociates to Grb2 and DiL12CU
Grb2 and DiL12LU bind yielding DiL12LG DiL12LG dissociates to Grb2 and DiL12LU DiL12LU transforms in (singly-bound -> doubly-bound) DiL12CC DiL12CC tranforms in (doubly-bound -> singly-bound) DiL12LU
Cbl and DiL12UG bind yielding DiL12CG DiL12CG dissociates to Cbl and DiL12UG CG and DiL12UG bind yielding DiL12LG DiL12LG dissociates to CG and DiL12UG
Cbl and DiL12UG bind yielding DiL12UL DiL12UL dissociates to Cbl and DiL12UG DiL12UL transforms in (singly-bound -> doubly-bound) DiL12CC DiL12CC tranforms in (doubly-bound -> singly-bound) DiL12UL
DiL12CG transforms in (Cbl bind Grb2 directly) DiL12CC DiL12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) DiL12CG Grb2 and DiL12CG bind yielding DiL12LG DiL12LG dissociates to Grb2 and DiL12CG
Cbl and DaL10UU bind yielding DaL10CU DaL10CU dissociates to Cbl and DaL10UU CG and DaL10UU bind yielding DaL10LU DaL10LU dissociates to CG and DaL10UU
Grb2 and DaL10CU bind yielding DaL10LU DaL10LU dissociates to Grb2 and DaL10CU Grb2 and DaL01UU bind yielding DaL01UG DaL01UG dissociates to Grb2 and DaL01UU
CG and DaL01UU bind yielding DaL01UL DaL01UL dissociates to CG and DaL01UU Cbl and DaL01UG bind yielding DaL01UL DaL01UL dissociates to Cbl and DaL01UG
Cbl and DaL11UU bind yielding DaL11CU DaL11CU dissociates to Cbl and DaL11UU CG and DaL11UU bind yielding DaL11LU DaL11LU dissociates to CG and DaL11UU
Grb2 and DaL11UU bind yielding DaL11UG DaL11UG dissociates to Grb2 and DaL11UU CG and DaL11UU bind yielding DaL11UL DaL11UL dissociates to CG and DaL11UU
Grb2 and DaL11CU bind yielding DaL11LU DaL11LU dissociates to Grb2 and DaL11CU Grb2 and DaL11CU bind yielding DaL11CG DaL11CG dissociates to Grb2 and DaL11CU
Grb2 and DaL11LU bind yielding DaL11LG DaL11LG dissociates to Grb2 and DaL11LU DaL11LU transforms in (singly-bound -> doubly-bound) DaL11CC DaL11CC tranforms in (doubly-bound -> singly-bound) DaL11LU
Cbl and DaL11UG bind yielding DaL11CG DaL11CG dissociates to Cbl and DaL11UG CG and DaL11UG bind yielding DaL11LG DaL11LG dissociates to CG and DaL11UG
Cbl and DaL11UG bind yielding DaL11UL DaL11UL dissociates to Cbl and DaL11UG DaL11UL transforms in (singly-bound -> doubly-bound) DaL11CC DaL11CC tranforms in (doubly-bound -> singly-bound) DaL11UL
DaL11CG transforms in (Cbl bind Grb2 directly) DaL11CC DaL11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) DaL11CG Grb2 and DaL11CG bind yielding DaL11LG DaL11LG dissociates to Grb2 and DaL11CG
Grb2 and DaL02UU bind yielding DaL02UG DaL02UG dissociates to Grb2 and DaL02UU CG and DaL02UU bind yielding DaL02UL DaL02UL dissociates to CG and DaL02UU
Cbl and DaL02UG bind yielding DaL02UL DaL02UL dissociates to Cbl and DaL02UG Cbl and DaL12UU bind yielding DaL12CU DaL12CU dissociates to Cbl and DaL12UU
CG and DaL12UU bind yielding DaL12LU DaL12LU dissociates to CG and DaL12UU Grb2 and DaL12UU bind yielding DaL12UG DaL12UG dissociates to Grb2 and DaL12UU
CG and DaL12UU bind yielding DaL12UL DaL12UL dissociates to CG and DaL12UU Grb2 and DaL12CU bind yielding DaL12LU DaL12LU dissociates to Grb2 and DaL12CU
Grb2 and DaL12CU bind yielding DaL12CG DaL12CG dissociates to Grb2 and DaL12CU Grb2 and DaL12LU bind yielding DaL12LG DaL12LG dissociates to Grb2 and DaL12LU
DaL12LU transforms in (singly-bound -> doubly-bound) DaL12CC DaL12CC tranforms in (doubly-bound -> singly-bound) DaL12LU Cbl and DaL12UG bind yielding DaL12CG DaL12CG dissociates to Cbl and DaL12UG
CG and DaL12UG bind yielding DaL12LG DaL12LG dissociates to CG and DaL12UG Cbl and DaL12UG bind yielding DaL12UL DaL12UL dissociates to Cbl and DaL12UG
DaL12UL transforms in (singly-bound -> doubly-bound) DaL12CC DaL12CC tranforms in (doubly-bound -> singly-bound) DaL12UL DaL12CG transforms in (Cbl bind Grb2 directly) DaL12CC DaL12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) DaL12CG
Grb2 and DaL12CG bind yielding DaL12LG DaL12LG dissociates to Grb2 and DaL12CG R00UU closes R10UU closes
R10CU closes R10LU closes R01UU closes R01UG closes
R01UL closes R11UU closes R11CU closes R11LU closes
R11UG closes R11UL closes R11CG closes R11CC closes
R11LG closes R02UU closes R02UG closes R02UL closes
R12UU closes R12CU closes R12LU closes R12UG closes
R12UL closes R12CG closes R12CC closes R12LG closes
Rc00UU opens Rc10UU opens Rc10CU opens Rc10LU opens
Rc01UU opens Rc01UG opens Rc01UL opens Rc11UU opens
Rc11CU opens Rc11LU opens Rc11UG opens Rc11UL opens
Rc11CG opens Rc11CC opens Rc11LG opens Rc02UU opens
Rc02UG opens Rc02UL opens Rc12UU opens Rc12CU opens
Rc12LU opens Rc12UG opens Rc12UL opens Rc12CG opens
Rc12CC opens Rc12LG opens RL00UU closes RL10UU closes
RL10CU closes RL10LU closes RL01UU closes RL01UG closes
RL01UL closes RL11UU closes RL11CU closes RL11LU closes
RL11UG closes RL11UL closes RL11CG closes RL11CC closes
RL11LG closes RL02UU closes RL02UG closes RL02UL closes
RL12UU closes RL12CU closes RL12LU closes RL12UG closes
RL12UL closes RL12CG closes RL12CC closes RL12LG closes
RcL00UU opens RcL10UU opens RcL10CU opens RcL10LU opens
RcL01UU opens RcL01UG opens RcL01UL opens RcL11UU opens
RcL11CU opens RcL11LU opens RcL11UG opens RcL11UL opens
RcL11CG opens RcL11CC opens RcL11LG opens RcL02UU opens
RcL02UG opens RcL02UL opens RcL12UU opens RcL12CU opens
RcL12LU opens RcL12UG opens RcL12UL opens RcL12CG opens
RcL12CC opens RcL12LG opens R00UU binds ligand R10UU binds ligand
R10CU binds ligand R10LU binds ligand R01UU binds ligand R01UG binds ligand
R01UL binds ligand R11UU binds ligand R11CU binds ligand R11LU binds ligand
R11UG binds ligand R11UL binds ligand R11CG binds ligand R11CC binds ligand
R11LG binds ligand R02UU binds ligand R02UG binds ligand R02UL binds ligand
R12UU binds ligand R12CU binds ligand R12LU binds ligand R12UG binds ligand
R12UL binds ligand R12CG binds ligand R12CC binds ligand R12LG binds ligand
Rc00UU binds ligand Rc10UU binds ligand Rc10CU binds ligand Rc10LU binds ligand
Rc01UU binds ligand Rc01UG binds ligand Rc01UL binds ligand Rc11UU binds ligand
Rc11CU binds ligand Rc11LU binds ligand Rc11UG binds ligand Rc11UL binds ligand
Rc11CG binds ligand Rc11CC binds ligand Rc11LG binds ligand Rc02UU binds ligand
Rc02UG binds ligand Rc02UL binds ligand Rc12UU binds ligand Rc12CU binds ligand
Rc12LU binds ligand Rc12UG binds ligand Rc12UL binds ligand Rc12CG binds ligand
Rc12CC binds ligand Rc12LG binds ligand Di00UU partner binds ligand Di10UU partner binds ligand
Di10CU partner binds ligand Di10LU partner binds ligand Di01UU partner binds ligand Di01UG partner binds ligand
Di01UL partner binds ligand Di11UU partner binds ligand Di11CU partner binds ligand Di11LU partner binds ligand
Di11UG partner binds ligand Di11UL partner binds ligand Di11CG partner binds ligand Di11CC partner binds ligand
Di11LG partner binds ligand Di02UU partner binds ligand Di02UG partner binds ligand Di02UL partner binds ligand
Di12UU partner binds ligand Di12CU partner binds ligand Di12LU partner binds ligand Di12UG partner binds ligand
Di12UL partner binds ligand Di12CG partner binds ligand Di12CC partner binds ligand Di12LG partner binds ligand
Di00UU binds ligand Di10UU binds ligand Di10CU binds ligand Di10LU binds ligand
Di01UU binds ligand Di01UG binds ligand Di01UL binds ligand Di11UU binds ligand
Di11CU binds ligand Di11LU binds ligand Di11UG binds ligand Di11UL binds ligand
Di11CG binds ligand Di11CC binds ligand Di11LG binds ligand Di02UU binds ligand
Di02UG binds ligand Di02UL binds ligand Di12UU binds ligand Di12CU binds ligand
Di12LU binds ligand Di12UG binds ligand Di12UL binds ligand Di12CG binds ligand
Di12CC binds ligand Di12LG binds ligand Da00UU binds ligand Da10UU binds ligand
Da10CU binds ligand Da10LU binds ligand Da01UU binds ligand Da01UG binds ligand
Da01UL binds ligand Da11UU binds ligand Da11CU binds ligand Da11LU binds ligand
Da11UG binds ligand Da11UL binds ligand Da11CG binds ligand Da11CC binds ligand
Da11LG binds ligand Da02UU binds ligand Da02UG binds ligand Da02UL binds ligand
Da12UU binds ligand Da12CU binds ligand Da12LU binds ligand Da12UG binds ligand
Da12UL binds ligand Da12CG binds ligand Da12CC binds ligand Da12LG binds ligand
DiL00UU partner binds ligand DiL10UU partner binds ligand DiL10CU partner binds ligand DiL10LU partner binds ligand
DiL01UU partner binds ligand DiL01UG partner binds ligand DiL01UL partner binds ligand DiL11UU partner binds ligand
DiL11CU partner binds ligand DiL11LU partner binds ligand DiL11UG partner binds ligand DiL11UL partner binds ligand
DiL11CG partner binds ligand DiL11CC partner binds ligand DiL11LG partner binds ligand DiL02UU partner binds ligand
DiL02UG partner binds ligand DiL02UL partner binds ligand DiL12UU partner binds ligand DiL12CU partner binds ligand
DiL12LU partner binds ligand DiL12UG partner binds ligand DiL12UL partner binds ligand DiL12CG partner binds ligand
DiL12CC partner binds ligand DiL12LG partner binds ligand RL00UU dissociates ligand RL10UU dissociates ligand
RL10CU dissociates ligand RL10LU dissociates ligand RL01UU dissociates ligand RL01UG dissociates ligand
RL01UL dissociates ligand RL11UU dissociates ligand RL11CU dissociates ligand RL11LU dissociates ligand
RL11UG dissociates ligand RL11UL dissociates ligand RL11CG dissociates ligand RL11CC dissociates ligand
RL11LG dissociates ligand RL02UU dissociates ligand RL02UG dissociates ligand RL02UL dissociates ligand
RL12UU dissociates ligand RL12CU dissociates ligand RL12LU dissociates ligand RL12UG dissociates ligand
RL12UL dissociates ligand RL12CG dissociates ligand RL12CC dissociates ligand RL12LG dissociates ligand
RcL00UU dissociates ligand RcL10UU dissociates ligand RcL10CU dissociates ligand RcL10LU dissociates ligand
RcL01UU dissociates ligand RcL01UG dissociates ligand RcL01UL dissociates ligand RcL11UU dissociates ligand
RcL11CU dissociates ligand RcL11LU dissociates ligand RcL11UG dissociates ligand RcL11UL dissociates ligand
RcL11CG dissociates ligand RcL11CC dissociates ligand RcL11LG dissociates ligand RcL02UU dissociates ligand
RcL02UG dissociates ligand RcL02UL dissociates ligand RcL12UU dissociates ligand RcL12CU dissociates ligand
RcL12LU dissociates ligand RcL12UG dissociates ligand RcL12UL dissociates ligand RcL12CG dissociates ligand
RcL12CC dissociates ligand RcL12LG dissociates ligand DaL00UU partner dissociates its ligand DaL10UU partner dissociates its ligand
DaL10CU partner dissociates its ligand DaL10LU partner dissociates its ligand DaL01UU partner dissociates its ligand DaL01UG partner dissociates its ligand
DaL01UL partner dissociates its ligand DaL11UU partner dissociates its ligand DaL11CU partner dissociates its ligand DaL11LU partner dissociates its ligand
DaL11UG partner dissociates its ligand DaL11UL partner dissociates its ligand DaL11CG partner dissociates its ligand DaL11CC partner dissociates its ligand
DaL11LG partner dissociates its ligand DaL02UU partner dissociates its ligand DaL02UG partner dissociates its ligand DaL02UL partner dissociates its ligand
DaL12UU partner dissociates its ligand DaL12CU partner dissociates its ligand DaL12LU partner dissociates its ligand DaL12UG partner dissociates its ligand
DaL12UL partner dissociates its ligand DaL12CG partner dissociates its ligand DaL12CC partner dissociates its ligand DaL12LG partner dissociates its ligand
DaL00UU dissociates its ligand DaL10UU dissociates its ligand DaL10CU dissociates its ligand DaL10LU dissociates its ligand
DaL01UU dissociates its ligand DaL01UG dissociates its ligand DaL01UL dissociates its ligand DaL11UU dissociates its ligand
DaL11CU dissociates its ligand DaL11LU dissociates its ligand DaL11UG dissociates its ligand DaL11UL dissociates its ligand
DaL11CG dissociates its ligand DaL11CC dissociates its ligand DaL11LG dissociates its ligand DaL02UU dissociates its ligand
DaL02UG dissociates its ligand DaL02UL dissociates its ligand DaL12UU dissociates its ligand DaL12CU dissociates its ligand
DaL12LU dissociates its ligand DaL12UG dissociates its ligand DaL12UL dissociates its ligand DaL12CG dissociates its ligand
DaL12CC dissociates its ligand DaL12LG dissociates its ligand Da00UU partner dissociates its ligand Da10UU partner dissociates its ligand
Da10CU partner dissociates its ligand Da10LU partner dissociates its ligand Da01UU partner dissociates its ligand Da01UG partner dissociates its ligand
Da01UL partner dissociates its ligand Da11UU partner dissociates its ligand Da11CU partner dissociates its ligand Da11LU partner dissociates its ligand
Da11UG partner dissociates its ligand Da11UL partner dissociates its ligand Da11CG partner dissociates its ligand Da11CC partner dissociates its ligand
Da11LG partner dissociates its ligand Da02UU partner dissociates its ligand Da02UG partner dissociates its ligand Da02UL partner dissociates its ligand
Da12UU partner dissociates its ligand Da12CU partner dissociates its ligand Da12LU partner dissociates its ligand Da12UG partner dissociates its ligand
Da12UL partner dissociates its ligand Da12CG partner dissociates its ligand Da12CC partner dissociates its ligand Da12LG partner dissociates its ligand
DiL00UU dissociates its ligand DiL10UU dissociates its ligand DiL10CU dissociates its ligand DiL10LU dissociates its ligand
DiL01UU dissociates its ligand DiL01UG dissociates its ligand DiL01UL dissociates its ligand DiL11UU dissociates its ligand
DiL11CU dissociates its ligand DiL11LU dissociates its ligand DiL11UG dissociates its ligand DiL11UL dissociates its ligand
DiL11CG dissociates its ligand DiL11CC dissociates its ligand DiL11LG dissociates its ligand DiL02UU dissociates its ligand
DiL02UG dissociates its ligand DiL02UL dissociates its ligand DiL12UU dissociates its ligand DiL12CU dissociates its ligand
DiL12LU dissociates its ligand DiL12UG dissociates its ligand DiL12UL dissociates its ligand DiL12CG dissociates its ligand
DiL12CC dissociates its ligand DiL12LG dissociates its ligand R00UU dimerizes to Di00UU R10UU dimerizes to Di10UU
R10CU dimerizes to Di10CU R10LU dimerizes to Di10LU R01UU dimerizes to Di01UU R01UG dimerizes to Di01UG
R01UL dimerizes to Di01UL R11UU dimerizes to Di11UU R11CU dimerizes to Di11CU R11LU dimerizes to Di11LU
R11UG dimerizes to Di11UG R11UL dimerizes to Di11UL R11CG dimerizes to Di11CG R11CC dimerizes to Di11CC
R11LG dimerizes to Di11LG R02UU dimerizes to Di02UU R02UG dimerizes to Di02UG R02UL dimerizes to Di02UL
R12UU dimerizes to Di12UU R12CU dimerizes to Di12CU R12LU dimerizes to Di12LU R12UG dimerizes to Di12UG
R12UL dimerizes to Di12UL R12CG dimerizes to Di12CG R12CC dimerizes to Di12CC R12LG dimerizes to Di12LG
R00UU dimerizes to Da00UU R10UU dimerizes to Da10UU R10CU dimerizes to Da10CU R10LU dimerizes to Da10LU
R01UU dimerizes to Da01UU R01UG dimerizes to Da01UG R01UL dimerizes to Da01UL R11UU dimerizes to Da11UU
R11CU dimerizes to Da11CU R11LU dimerizes to Da11LU R11UG dimerizes to Da11UG R11UL dimerizes to Da11UL
R11CG dimerizes to Da11CG R11CC dimerizes to Da11CC R11LG dimerizes to Da11LG R02UU dimerizes to Da02UU
R02UG dimerizes to Da02UG R02UL dimerizes to Da02UL R12UU dimerizes to Da12UU R12CU dimerizes to Da12CU
R12LU dimerizes to Da12LU R12UG dimerizes to Da12UG R12UL dimerizes to Da12UL R12CG dimerizes to Da12CG
R12CC dimerizes to Da12CC R12LG dimerizes to Da12LG RL00UU dimerizes to DiL00UU RL10UU dimerizes to DiL10UU
RL10CU dimerizes to DiL10CU RL10LU dimerizes to DiL10LU RL01UU dimerizes to DiL01UU RL01UG dimerizes to DiL01UG
RL01UL dimerizes to DiL01UL RL11UU dimerizes to DiL11UU RL11CU dimerizes to DiL11CU RL11LU dimerizes to DiL11LU
RL11UG dimerizes to DiL11UG RL11UL dimerizes to DiL11UL RL11CG dimerizes to DiL11CG RL11CC dimerizes to DiL11CC
RL11LG dimerizes to DiL11LG RL02UU dimerizes to DiL02UU RL02UG dimerizes to DiL02UG RL02UL dimerizes to DiL02UL
RL12UU dimerizes to DiL12UU RL12CU dimerizes to DiL12CU RL12LU dimerizes to DiL12LU RL12UG dimerizes to DiL12UG
RL12UL dimerizes to DiL12UL RL12CG dimerizes to DiL12CG RL12CC dimerizes to DiL12CC RL12LG dimerizes to DiL12LG
RL00UU dimerizes to DaL00UU RL10UU dimerizes to DaL10UU RL10CU dimerizes to DaL10CU RL10LU dimerizes to DaL10LU
RL01UU dimerizes to DaL01UU RL01UG dimerizes to DaL01UG RL01UL dimerizes to DaL01UL RL11UU dimerizes to DaL11UU
RL11CU dimerizes to DaL11CU RL11LU dimerizes to DaL11LU RL11UG dimerizes to DaL11UG RL11UL dimerizes to DaL11UL
RL11CG dimerizes to DaL11CG RL11CC dimerizes to DaL11CC RL11LG dimerizes to DaL11LG RL02UU dimerizes to DaL02UU
RL02UG dimerizes to DaL02UG RL02UL dimerizes to DaL02UL RL12UU dimerizes to DaL12UU RL12CU dimerizes to DaL12CU
RL12LU dimerizes to DaL12LU RL12UG dimerizes to DaL12UG RL12UL dimerizes to DaL12UL RL12CG dimerizes to DaL12CG
RL12CC dimerizes to DaL12CC RL12LG dimerizes to DaL12LG Di00UU loses partner Di10UU loses partner
Di10CU loses partner Di10LU loses partner Di01UU loses partner Di01UG loses partner
Di01UL loses partner Di11UU loses partner Di11CU loses partner Di11LU loses partner
Di11UG loses partner Di11UL loses partner Di11CG loses partner Di11CC loses partner
Di11LG loses partner Di02UU loses partner Di02UG loses partner Di02UL loses partner
Di12UU loses partner Di12CU loses partner Di12LU loses partner Di12UG loses partner
Di12UL loses partner Di12CG loses partner Di12CC loses partner Di12LG loses partner
DiL00UU loses partner DiL10UU loses partner DiL10CU loses partner DiL10LU loses partner
DiL01UU loses partner DiL01UG loses partner DiL01UL loses partner DiL11UU loses partner
DiL11CU loses partner DiL11LU loses partner DiL11UG loses partner DiL11UL loses partner
DiL11CG loses partner DiL11CC loses partner DiL11LG loses partner DiL02UU loses partner
DiL02UG loses partner DiL02UL loses partner DiL12UU loses partner DiL12CU loses partner
DiL12LU loses partner DiL12UG loses partner DiL12UL loses partner DiL12CG loses partner
DiL12CC loses partner DiL12LG loses partner Da00UU loses partner Da10UU loses partner
Da10CU loses partner Da10LU loses partner Da01UU loses partner Da01UG loses partner
Da01UL loses partner Da11UU loses partner Da11CU loses partner Da11LU loses partner
Da11UG loses partner Da11UL loses partner Da11CG loses partner Da11CC loses partner
Da11LG loses partner Da02UU loses partner Da02UG loses partner Da02UL loses partner
Da12UU loses partner Da12CU loses partner Da12LU loses partner Da12UG loses partner
Da12UL loses partner Da12CG loses partner Da12CC loses partner Da12LG loses partner
DaL00UU loses partner DaL10UU loses partner DaL10CU loses partner DaL10LU loses partner
DaL01UU loses partner DaL01UG loses partner DaL01UL loses partner DaL11UU loses partner
DaL11CU loses partner DaL11LU loses partner DaL11UG loses partner DaL11UL loses partner
DaL11CG loses partner DaL11CC loses partner DaL11LG loses partner DaL02UU loses partner
DaL02UG loses partner DaL02UL loses partner DaL12UU loses partner DaL12CU loses partner
DaL12LU loses partner DaL12UG loses partner DaL12UL loses partner DaL12CG loses partner
DaL12CC loses partner DaL12LG loses partner R00UU extra homodimerizes to Di00UU R10UU extra homodimerizes to Di10UU
R10CU extra homodimerizes to Di10CU R10LU extra homodimerizes to Di10LU R01UU extra homodimerizes to Di01UU R01UG extra homodimerizes to Di01UG
R01UL extra homodimerizes to Di01UL R11UU extra homodimerizes to Di11UU R11CU extra homodimerizes to Di11CU R11LU extra homodimerizes to Di11LU
R11UG extra homodimerizes to Di11UG R11UL extra homodimerizes to Di11UL R11CG extra homodimerizes to Di11CG R11CC extra homodimerizes to Di11CC
R11LG extra homodimerizes to Di11LG R02UU extra homodimerizes to Di02UU R02UG extra homodimerizes to Di02UG R02UL extra homodimerizes to Di02UL
R12UU extra homodimerizes to Di12UU R12CU extra homodimerizes to Di12CU R12LU extra homodimerizes to Di12LU R12UG extra homodimerizes to Di12UG
R12UL extra homodimerizes to Di12UL R12CG extra homodimerizes to Di12CG R12CC extra homodimerizes to Di12CC R12LG extra homodimerizes to Di12LG
RL00UU extra homodimerizes to DaL00UU RL10UU extra homodimerizes to DaL10UU RL10CU extra homodimerizes to DaL10CU RL10LU extra homodimerizes to DaL10LU
RL01UU extra homodimerizes to DaL01UU RL01UG extra homodimerizes to DaL01UG RL01UL extra homodimerizes to DaL01UL RL11UU extra homodimerizes to DaL11UU
RL11CU extra homodimerizes to DaL11CU RL11LU extra homodimerizes to DaL11LU RL11UG extra homodimerizes to DaL11UG RL11UL extra homodimerizes to DaL11UL
RL11CG extra homodimerizes to DaL11CG RL11CC extra homodimerizes to DaL11CC RL11LG extra homodimerizes to DaL11LG RL02UU extra homodimerizes to DaL02UU
RL02UG extra homodimerizes to DaL02UG RL02UL extra homodimerizes to DaL02UL RL12UU extra homodimerizes to DaL12UU RL12CU extra homodimerizes to DaL12CU
RL12LU extra homodimerizes to DaL12LU RL12UG extra homodimerizes to DaL12UG RL12UL extra homodimerizes to DaL12UL RL12CG extra homodimerizes to DaL12CG
RL12CC extra homodimerizes to DaL12CC RL12LG extra homodimerizes to DaL12LG    
Rules
Assignment Rule (variable: Ke1) Assignment Rule (variable: K45P) Assignment Rule (variable: KcgP) Assignment Rule (variable: ku)
Assignment Rule (variable: ko) Assignment Rule (variable: k1b) Assignment Rule (variable: k1o) Assignment Rule (variable: kkin68)
Assignment Rule (variable: kptp68) Assignment Rule (variable: kb45) Assignment Rule (variable: kb68) Assignment Rule (variable: ku68)
Assignment Rule (variable: kbcg) Assignment Rule (variable: ku45M) Assignment Rule (variable: kb45P) Assignment Rule (variable: kb68P)
Assignment Rule (variable: ku68M) Assignment Rule (variable: kucgM) Assignment Rule (variable: kbcgP) Assignment Rule (variable: SumM)
Assignment Rule (variable: SumML) Assignment Rule (variable: PY) Assignment Rule (variable: Ub) Assignment Rule (variable: PYNorm)
Assignment Rule (variable: UbNorm)      
Physical entities
Compartments Species
cell L Cbl Grb2
CG PY Ub
PYNorm UbNorm SumM
SumML Rc00UU Rc10UU
Rc10CU Rc10LU Rc01UU
Rc01UG Rc01UL Rc11UU
Rc11CU Rc11LU Rc11UG
Rc11UL Rc11CG Rc11CC
Rc11LG Rc02UU Rc02UG
Rc02UL Rc12UU Rc12CU
Rc12LU Rc12UG Rc12UL
Rc12CG Rc12CC Rc12LG
RcL00UU RcL10UU RcL10CU
RcL10LU RcL01UU RcL01UG
RcL01UL RcL11UU RcL11CU
RcL11LU RcL11UG RcL11UL
RcL11CG RcL11CC RcL11LG
RcL02UU RcL02UG RcL02UL
RcL12UU RcL12CU RcL12LU
RcL12UG RcL12UL RcL12CG
RcL12CC RcL12LG R00UU
R10UU R10CU R10LU
R01UU R01UG R01UL
R11UU R11CU R11LU
R11UG R11UL R11CG
R11CC R11LG R02UU
R02UG R02UL R12UU
R12CU R12LU R12UG
R12UL R12CG R12CC
R12LG RL00UU RL10UU
RL10CU RL10LU RL01UU
RL01UG RL01UL RL11UU
RL11CU RL11LU RL11UG
RL11UL RL11CG RL11CC
RL11LG RL02UU RL02UG
RL02UL RL12UU RL12CU
RL12LU RL12UG RL12UL
RL12CG RL12CC RL12LG
Di00UU Di10UU Di10CU
Di10LU Di01UU Di01UG
Di01UL Di11UU Di11CU
Di11LU Di11UG Di11UL
Di11CG Di11CC Di11LG
Di02UU Di02UG Di02UL
Di12UU Di12CU Di12LU
Di12UG Di12UL Di12CG
Di12CC Di12LG Da00UU
Da10UU Da10CU Da10LU
Da01UU Da01UG Da01UL
Da11UU Da11CU Da11LU
Da11UG Da11UL Da11CG
Da11CC Da11LG Da02UU
Da02UG Da02UL Da12UU
Da12CU Da12LU Da12UG
Da12UL Da12CG Da12CC
Da12LG DiL00UU DiL10UU
DiL10CU DiL10LU DiL01UU
DiL01UG DiL01UL DiL11UU
DiL11CU DiL11LU DiL11UG
DiL11UL DiL11CG DiL11CC
DiL11LG DiL02UU DiL02UG
DiL02UL DiL12UU DiL12CU
DiL12LU DiL12UG DiL12UL
DiL12CG DiL12CC DiL12LG
DaL00UU DaL10UU DaL10CU
DaL10LU DaL01UU DaL01UG
DaL01UL DaL11UU DaL11CU
DaL11LU DaL11UG DaL11UL
DaL11CG DaL11CC DaL11LG
DaL02UU DaL02UG DaL02UL
DaL12UU DaL12CU DaL12LU
DaL12UG DaL12UL DaL12CG
DaL12CC DaL12LG  
Global parameters
Ke1 K45P KcgP ku
ko k1b k1o kptp68
kkin68 kb45 ku45M kb45P
kb68 ku68 kb68P ku68M
kbcg kbcgP kucgM Ltot
RT CblT Grb2T K
Ke K1 kptp kkin
K45 Kcg ku45 kucg
kb kc kuDIM kbDIM
k1u k1c PYMax UbMax
floc CblWT CblFactor  
Reactions (1490)
 
 Rc10UU has site Y1045 dephosphorylated [Rc10UU] ↔ [Rc00UU];   {Rc10UU}
 
 Rc01UU has site Y1068/Y1086 dephosphorylated [Rc01UU] ↔ [Rc00UU];   {Rc01UU}
 
 Rc11UU has site Y1045 dephosphorylated [Rc11UU] ↔ [Rc01UU];   {Rc11UU}
 
 Rc11UU has site Y1068/Y1086 dephosphorylated [Rc11UU] ↔ [Rc10UU];   {Rc11UU}
 
 Rc11CU has site Y1068/Y1086 dephosphorylated [Rc11CU] ↔ [Rc10CU];   {Rc11CU}
 
 Rc11LU has site Y1068/Y1086 dephosphorylated [Rc11LU] ↔ [Rc10LU];   {Rc11LU}
 
 Rc11UG has site Y1045 dephosphorylated [Rc11UG] ↔ [Rc01UG];   {Rc11UG}
 
 Rc11UL has site Y1045 dephosphorylated [Rc11UL] ↔ [Rc01UL];   {Rc11UL}
 
 Rc02UU has site Y1068/Y1086 dephosphorylated [Rc02UU] ↔ [Rc01UU];   {Rc02UU}
 
 Rc02UG has site Y1068/Y1-86 dephosphorylated [Rc02UG] ↔ [Rc01UG];   {Rc02UG}
 
 Rc02UL has site Y1068/Y1-86 dephosphorylated [Rc02UL] ↔ [Rc01UL];   {Rc02UL}
 
 Rc12UU has site Y1045 dephosphorylated [Rc12UU] ↔ [Rc02UU];   {Rc12UU}
 
 Rc12UU has site Y1068/Y1086 dephosphorylated [Rc12UU] ↔ [Rc11UU];   {Rc12UU}
 
 Rc12CU has site Y1068/Y1086 dephosphorylated [Rc12CU] ↔ [Rc11CU];   {Rc12CU}
 
 Rc12LU has site Y1068/Y1086 dephosphorylated [Rc12LU] ↔ [Rc11LU];   {Rc12LU}
 
 Rc12UG has site Y1045 dephosphorylated [Rc12UG] ↔ [Rc02UG];   {Rc12UG}
 
 Rc12UG has site Y1068/Y1-86 dephosphorylated [Rc12UG] ↔ [Rc11UG];   {Rc12UG}
 
 Rc12UL has site Y1045 dephosphorylated [Rc12UL] ↔ [Rc02UL];   {Rc12UL}
 
 Rc12UL has site Y1068/Y1-86 dephosphorylated [Rc12UL] ↔ [Rc11UL];   {Rc12UL}
 
 Rc12CG has site Y1068/Y1-86 dephosphorylated [Rc12CG] ↔ [Rc11CG];   {Rc12CG}
 
 Rc12CC has site Y1068/Y1-86 dephosphorylated [Rc12CC] ↔ [Rc11CC];   {Rc12CC}
 
 Rc12LG has site Y1068/Y1-86 dephosphorylated [Rc12LG] ↔ [Rc11LG];   {Rc12LG}
 
 RcL10UU has site Y1045 dephosphorylated [RcL10UU] ↔ [RcL00UU];   {RcL10UU}
 
 RcL01UU has site Y1068/Y1086 dephosphorylated [RcL01UU] ↔ [RcL00UU];   {RcL01UU}
 
 RcL11UU has site Y1045 dephosphorylated [RcL11UU] ↔ [RcL01UU];   {RcL11UU}
 
 RcL11UU has site Y1068/Y1086 dephosphorylated [RcL11UU] ↔ [RcL10UU];   {RcL11UU}
 
 RcL11CU has site Y1068/Y1086 dephosphorylated [RcL11CU] ↔ [RcL10CU];   {RcL11CU}
 
 RcL11LU has site Y1068/Y1086 dephosphorylated [RcL11LU] ↔ [RcL10LU];   {RcL11LU}
 
 RcL11UG has site Y1045 dephosphorylated [RcL11UG] ↔ [RcL01UG];   {RcL11UG}
 
 RcL11UL has site Y1045 dephosphorylated [RcL11UL] ↔ [RcL01UL];   {RcL11UL}
 
 RcL02UU has site Y1068/Y1086 dephosphorylated [RcL02UU] ↔ [RcL01UU];   {RcL02UU}
 
 RcL02UG has site Y1068/Y1-86 dephosphorylated [RcL02UG] ↔ [RcL01UG];   {RcL02UG}
 
 RcL02UL has site Y1068/Y1-86 dephosphorylated [RcL02UL] ↔ [RcL01UL];   {RcL02UL}
 
 RcL12UU has site Y1045 dephosphorylated [RcL12UU] ↔ [RcL02UU];   {RcL12UU}
 
 RcL12UU has site Y1068/Y1086 dephosphorylated [RcL12UU] ↔ [RcL11UU];   {RcL12UU}
 
 RcL12CU has site Y1068/Y1086 dephosphorylated [RcL12CU] ↔ [RcL11CU];   {RcL12CU}
 
 RcL12LU has site Y1068/Y1086 dephosphorylated [RcL12LU] ↔ [RcL11LU];   {RcL12LU}
 
 RcL12UG has site Y1045 dephosphorylated [RcL12UG] ↔ [RcL02UG];   {RcL12UG}
 
 RcL12UG has site Y1068/Y1-86 dephosphorylated [RcL12UG] ↔ [RcL11UG];   {RcL12UG}
 
 RcL12UL has site Y1045 dephosphorylated [RcL12UL] ↔ [RcL02UL];   {RcL12UL}
 
 RcL12UL has site Y1068/Y1-86 dephosphorylated [RcL12UL] ↔ [RcL11UL];   {RcL12UL}
 
 RcL12CG has site Y1068/Y1-86 dephosphorylated [RcL12CG] ↔ [RcL11CG];   {RcL12CG}
 
 RcL12CC has site Y1068/Y1-86 dephosphorylated [RcL12CC] ↔ [RcL11CC];   {RcL12CC}
 
 RcL12LG has site Y1068/Y1-86 dephosphorylated [RcL12LG] ↔ [RcL11LG];   {RcL12LG}
 
 R10UU has site Y1045 dephosphorylated [R10UU] ↔ [R00UU];   {R10UU}
 
 R01UU has site Y1068/Y1086 dephosphorylated [R01UU] ↔ [R00UU];   {R01UU}
 
 R11UU has site Y1045 dephosphorylated [R11UU] ↔ [R01UU];   {R11UU}
 
 R11UU has site Y1068/Y1086 dephosphorylated [R11UU] ↔ [R10UU];   {R11UU}
 
 R11CU has site Y1068/Y1086 dephosphorylated [R11CU] ↔ [R10CU];   {R11CU}
 
 R11LU has site Y1068/Y1086 dephosphorylated [R11LU] ↔ [R10LU];   {R11LU}
 
 R11UG has site Y1045 dephosphorylated [R11UG] ↔ [R01UG];   {R11UG}
 
 R11UL has site Y1045 dephosphorylated [R11UL] ↔ [R01UL];   {R11UL}
 
 R02UU has site Y1068/Y1086 dephosphorylated [R02UU] ↔ [R01UU];   {R02UU}
 
 R02UG has site Y1068/Y1-86 dephosphorylated [R02UG] ↔ [R01UG];   {R02UG}
 
 R02UL has site Y1068/Y1-86 dephosphorylated [R02UL] ↔ [R01UL];   {R02UL}
 
 R12UU has site Y1045 dephosphorylated [R12UU] ↔ [R02UU];   {R12UU}
 
 R12UU has site Y1068/Y1086 dephosphorylated [R12UU] ↔ [R11UU];   {R12UU}
 
 R12CU has site Y1068/Y1086 dephosphorylated [R12CU] ↔ [R11CU];   {R12CU}
 
 R12LU has site Y1068/Y1086 dephosphorylated [R12LU] ↔ [R11LU];   {R12LU}
 
 R12UG has site Y1045 dephosphorylated [R12UG] ↔ [R02UG];   {R12UG}
 
 R12UG has site Y1068/Y1-86 dephosphorylated [R12UG] ↔ [R11UG];   {R12UG}
 
 R12UL has site Y1045 dephosphorylated [R12UL] ↔ [R02UL];   {R12UL}
 
 R12UL has site Y1068/Y1-86 dephosphorylated [R12UL] ↔ [R11UL];   {R12UL}
 
 R12CG has site Y1068/Y1-86 dephosphorylated [R12CG] ↔ [R11CG];   {R12CG}
 
 R12CC has site Y1068/Y1-86 dephosphorylated [R12CC] ↔ [R11CC];   {R12CC}
 
 R12LG has site Y1068/Y1-86 dephosphorylated [R12LG] ↔ [R11LG];   {R12LG}
 
 RL10UU has site Y1045 dephosphorylated [RL10UU] ↔ [RL00UU];   {RL10UU}
 
 RL01UU has site Y1068/Y1086 dephosphorylated [RL01UU] ↔ [RL00UU];   {RL01UU}
 
 RL11UU has site Y1045 dephosphorylated [RL11UU] ↔ [RL01UU];   {RL11UU}
 
 RL11UU has site Y1068/Y1086 dephosphorylated [RL11UU] ↔ [RL10UU];   {RL11UU}
 
 RL11CU has site Y1068/Y1086 dephosphorylated [RL11CU] ↔ [RL10CU];   {RL11CU}
 
 RL11LU has site Y1068/Y1086 dephosphorylated [RL11LU] ↔ [RL10LU];   {RL11LU}
 
 RL11UG has site Y1045 dephosphorylated [RL11UG] ↔ [RL01UG];   {RL11UG}
 
 RL11UL has site Y1045 dephosphorylated [RL11UL] ↔ [RL01UL];   {RL11UL}
 
 RL02UU has site Y1068/Y1086 dephosphorylated [RL02UU] ↔ [RL01UU];   {RL02UU}
 
 RL02UG has site Y1068/Y1-86 dephosphorylated [RL02UG] ↔ [RL01UG];   {RL02UG}
 
 RL02UL has site Y1068/Y1-86 dephosphorylated [RL02UL] ↔ [RL01UL];   {RL02UL}
 
 RL12UU has site Y1045 dephosphorylated [RL12UU] ↔ [RL02UU];   {RL12UU}
 
 RL12UU has site Y1068/Y1086 dephosphorylated [RL12UU] ↔ [RL11UU];   {RL12UU}
 
 RL12CU has site Y1068/Y1086 dephosphorylated [RL12CU] ↔ [RL11CU];   {RL12CU}
 
 RL12LU has site Y1068/Y1086 dephosphorylated [RL12LU] ↔ [RL11LU];   {RL12LU}
 
 RL12UG has site Y1045 dephosphorylated [RL12UG] ↔ [RL02UG];   {RL12UG}
 
 RL12UG has site Y1068/Y1-86 dephosphorylated [RL12UG] ↔ [RL11UG];   {RL12UG}
 
 RL12UL has site Y1045 dephosphorylated [RL12UL] ↔ [RL02UL];   {RL12UL}
 
 RL12UL has site Y1068/Y1-86 dephosphorylated [RL12UL] ↔ [RL11UL];   {RL12UL}
 
 RL12CG has site Y1068/Y1-86 dephosphorylated [RL12CG] ↔ [RL11CG];   {RL12CG}
 
 RL12CC has site Y1068/Y1-86 dephosphorylated [RL12CC] ↔ [RL11CC];   {RL12CC}
 
 RL12LG has site Y1068/Y1-86 dephosphorylated [RL12LG] ↔ [RL11LG];   {RL12LG}
 
 Di10UU has site Y1045 dephosphorylated [Di10UU] ↔ [Di00UU];   {Di10UU}
 
 Di01UU has site Y1068/Y1086 dephosphorylated [Di01UU] ↔ [Di00UU];   {Di01UU}
 
 Di11UU has site Y1045 dephosphorylated [Di11UU] ↔ [Di01UU];   {Di11UU}
 
 Di11UU has site Y1068/Y1086 dephosphorylated [Di11UU] ↔ [Di10UU];   {Di11UU}
 
 Di11CU has site Y1068/Y1086 dephosphorylated [Di11CU] ↔ [Di10CU];   {Di11CU}
 
 Di11LU has site Y1068/Y1086 dephosphorylated [Di11LU] ↔ [Di10LU];   {Di11LU}
 
 Di11UG has site Y1045 dephosphorylated [Di11UG] ↔ [Di01UG];   {Di11UG}
 
 Di11UL has site Y1045 dephosphorylated [Di11UL] ↔ [Di01UL];   {Di11UL}
 
 Di02UU has site Y1068/Y1086 dephosphorylated [Di02UU] ↔ [Di01UU];   {Di02UU}
 
 Di02UG has site Y1068/Y1-86 dephosphorylated [Di02UG] ↔ [Di01UG];   {Di02UG}
 
 Di02UL has site Y1068/Y1-86 dephosphorylated [Di02UL] ↔ [Di01UL];   {Di02UL}
 
 Di12UU has site Y1045 dephosphorylated [Di12UU] ↔ [Di02UU];   {Di12UU}
 
 Di12UU has site Y1068/Y1086 dephosphorylated [Di12UU] ↔ [Di11UU];   {Di12UU}
 
 Di12CU has site Y1068/Y1086 dephosphorylated [Di12CU] ↔ [Di11CU];   {Di12CU}
 
 Di12LU has site Y1068/Y1086 dephosphorylated [Di12LU] ↔ [Di11LU];   {Di12LU}
 
 Di12UG has site Y1045 dephosphorylated [Di12UG] ↔ [Di02UG];   {Di12UG}
 
 Di12UG has site Y1068/Y1-86 dephosphorylated [Di12UG] ↔ [Di11UG];   {Di12UG}
 
 Di12UL has site Y1045 dephosphorylated [Di12UL] ↔ [Di02UL];   {Di12UL}
 
 Di12UL has site Y1068/Y1-86 dephosphorylated [Di12UL] ↔ [Di11UL];   {Di12UL}
 
 Di12CG has site Y1068/Y1-86 dephosphorylated [Di12CG] ↔ [Di11CG];   {Di12CG}
 
 Di12CC has site Y1068/Y1-86 dephosphorylated [Di12CC] ↔ [Di11CC];   {Di12CC}
 
 Di12LG has site Y1068/Y1-86 dephosphorylated [Di12LG] ↔ [Di11LG];   {Di12LG}
 
 Da10UU has site Y1045 dephosphorylated [Da10UU] ↔ [Da00UU];   {Da10UU}
 
 Da01UU has site Y1068/Y1086 dephosphorylated [Da01UU] ↔ [Da00UU];   {Da01UU}
 
 Da11UU has site Y1045 dephosphorylated [Da11UU] ↔ [Da01UU];   {Da11UU}
 
 Da11UU has site Y1068/Y1086 dephosphorylated [Da11UU] ↔ [Da10UU];   {Da11UU}
 
 Da11CU has site Y1068/Y1086 dephosphorylated [Da11CU] ↔ [Da10CU];   {Da11CU}
 
 Da11LU has site Y1068/Y1086 dephosphorylated [Da11LU] ↔ [Da10LU];   {Da11LU}
 
 Da11UG has site Y1045 dephosphorylated [Da11UG] ↔ [Da01UG];   {Da11UG}
 
 Da11UL has site Y1045 dephosphorylated [Da11UL] ↔ [Da01UL];   {Da11UL}
 
 Da02UU has site Y1068/Y1086 dephosphorylated [Da02UU] ↔ [Da01UU];   {Da02UU}
 
 Da02UG has site Y1068/Y1-86 dephosphorylated [Da02UG] ↔ [Da01UG];   {Da02UG}
 
 Da02UL has site Y1068/Y1-86 dephosphorylated [Da02UL] ↔ [Da01UL];   {Da02UL}
 
 Da12UU has site Y1045 dephosphorylated [Da12UU] ↔ [Da02UU];   {Da12UU}
 
 Da12UU has site Y1068/Y1086 dephosphorylated [Da12UU] ↔ [Da11UU];   {Da12UU}
 
 Da12CU has site Y1068/Y1086 dephosphorylated [Da12CU] ↔ [Da11CU];   {Da12CU}
 
 Da12LU has site Y1068/Y1086 dephosphorylated [Da12LU] ↔ [Da11LU];   {Da12LU}
 
 Da12UG has site Y1045 dephosphorylated [Da12UG] ↔ [Da02UG];   {Da12UG}
 
 Da12UG has site Y1068/Y1-86 dephosphorylated [Da12UG] ↔ [Da11UG];   {Da12UG}
 
 Da12UL has site Y1045 dephosphorylated [Da12UL] ↔ [Da02UL];   {Da12UL}
 
 Da12UL has site Y1068/Y1-86 dephosphorylated [Da12UL] ↔ [Da11UL];   {Da12UL}
 
 Da12CG has site Y1068/Y1-86 dephosphorylated [Da12CG] ↔ [Da11CG];   {Da12CG}
 
 Da12CC has site Y1068/Y1-86 dephosphorylated [Da12CC] ↔ [Da11CC];   {Da12CC}
 
 Da12LG has site Y1068/Y1-86 dephosphorylated [Da12LG] ↔ [Da11LG];   {Da12LG}
 
 DiL10UU has site Y1045 dephosphorylated [DiL10UU] ↔ [DiL00UU];   {DiL10UU}
 
 DiL01UU has site Y1068/Y1086 dephosphorylated [DiL01UU] ↔ [DiL00UU];   {DiL01UU}
 
 DiL11UU has site Y1045 dephosphorylated [DiL11UU] ↔ [DiL01UU];   {DiL11UU}
 
 DiL11UU has site Y1068/Y1086 dephosphorylated [DiL11UU] ↔ [DiL10UU];   {DiL11UU}
 
 DiL11CU has site Y1068/Y1086 dephosphorylated [DiL11CU] ↔ [DiL10CU];   {DiL11CU}
 
 DiL11LU has site Y1068/Y1086 dephosphorylated [DiL11LU] ↔ [DiL10LU];   {DiL11LU}
 
 DiL11UG has site Y1045 dephosphorylated [DiL11UG] ↔ [DiL01UG];   {DiL11UG}
 
 DiL11UL has site Y1045 dephosphorylated [DiL11UL] ↔ [DiL01UL];   {DiL11UL}
 
 DiL02UU has site Y1068/Y1086 dephosphorylated [DiL02UU] ↔ [DiL01UU];   {DiL02UU}
 
 DiL02UG has site Y1068/Y1-86 dephosphorylated [DiL02UG] ↔ [DiL01UG];   {DiL02UG}
 
 DiL02UL has site Y1068/Y1-86 dephosphorylated [DiL02UL] ↔ [DiL01UL];   {DiL02UL}
 
 DiL12UU has site Y1045 dephosphorylated [DiL12UU] ↔ [DiL02UU];   {DiL12UU}
 
 DiL12UU has site Y1068/Y1086 dephosphorylated [DiL12UU] ↔ [DiL11UU];   {DiL12UU}
 
 DiL12CU has site Y1068/Y1086 dephosphorylated [DiL12CU] ↔ [DiL11CU];   {DiL12CU}
 
 DiL12LU has site Y1068/Y1086 dephosphorylated [DiL12LU] ↔ [DiL11LU];   {DiL12LU}
 
 DiL12UG has site Y1045 dephosphorylated [DiL12UG] ↔ [DiL02UG];   {DiL12UG}
 
 DiL12UG has site Y1068/Y1-86 dephosphorylated [DiL12UG] ↔ [DiL11UG];   {DiL12UG}
 
 DiL12UL has site Y1045 dephosphorylated [DiL12UL] ↔ [DiL02UL];   {DiL12UL}
 
 DiL12UL has site Y1068/Y1-86 dephosphorylated [DiL12UL] ↔ [DiL11UL];   {DiL12UL}
 
 DiL12CG has site Y1068/Y1-86 dephosphorylated [DiL12CG] ↔ [DiL11CG];   {DiL12CG}
 
 DiL12CC has site Y1068/Y1-86 dephosphorylated [DiL12CC] ↔ [DiL11CC];   {DiL12CC}
 
 DiL12LG has site Y1068/Y1-86 dephosphorylated [DiL12LG] ↔ [DiL11LG];   {DiL12LG}
 
 DaL10UU has site Y1045 dephosphorylated [DaL10UU] ↔ [DaL00UU];   {DaL10UU}
 
 DaL01UU has site Y1068/Y1086 dephosphorylated [DaL01UU] ↔ [DaL00UU];   {DaL01UU}
 
 DaL11UU has site Y1045 dephosphorylated [DaL11UU] ↔ [DaL01UU];   {DaL11UU}
 
 DaL11UU has site Y1068/Y1086 dephosphorylated [DaL11UU] ↔ [DaL10UU];   {DaL11UU}
 
 DaL11CU has site Y1068/Y1086 dephosphorylated [DaL11CU] ↔ [DaL10CU];   {DaL11CU}
 
 DaL11LU has site Y1068/Y1086 dephosphorylated [DaL11LU] ↔ [DaL10LU];   {DaL11LU}
 
 DaL11UG has site Y1045 dephosphorylated [DaL11UG] ↔ [DaL01UG];   {DaL11UG}
 
 DaL11UL has site Y1045 dephosphorylated [DaL11UL] ↔ [DaL01UL];   {DaL11UL}
 
 DaL02UU has site Y1068/Y1086 dephosphorylated [DaL02UU] ↔ [DaL01UU];   {DaL02UU}
 
 DaL02UG has site Y1068/Y1-86 dephosphorylated [DaL02UG] ↔ [DaL01UG];   {DaL02UG}
 
 DaL02UL has site Y1068/Y1-86 dephosphorylated [DaL02UL] ↔ [DaL01UL];   {DaL02UL}
 
 DaL12UU has site Y1045 dephosphorylated [DaL12UU] ↔ [DaL02UU];   {DaL12UU}
 
 DaL12UU has site Y1068/Y1086 dephosphorylated [DaL12UU] ↔ [DaL11UU];   {DaL12UU}
 
 DaL12CU has site Y1068/Y1086 dephosphorylated [DaL12CU] ↔ [DaL11CU];   {DaL12CU}
 
 DaL12LU has site Y1068/Y1086 dephosphorylated [DaL12LU] ↔ [DaL11LU];   {DaL12LU}
 
 DaL12UG has site Y1045 dephosphorylated [DaL12UG] ↔ [DaL02UG];   {DaL12UG}
 
 DaL12UG has site Y1068/Y1-86 dephosphorylated [DaL12UG] ↔ [DaL11UG];   {DaL12UG}
 
 DaL12UL has site Y1045 dephosphorylated [DaL12UL] ↔ [DaL02UL];   {DaL12UL}
 
 DaL12UL has site Y1068/Y1-86 dephosphorylated [DaL12UL] ↔ [DaL11UL];   {DaL12UL}
 
 DaL12CG has site Y1068/Y1-86 dephosphorylated [DaL12CG] ↔ [DaL11CG];   {DaL12CG}
 
 DaL12CC has site Y1068/Y1-86 dephosphorylated [DaL12CC] ↔ [DaL11CC];   {DaL12CC}
 
 DaL12LG has site Y1068/Y1-86 dephosphorylated [DaL12LG] ↔ [DaL11LG];   {DaL12LG}
 
 Da00UU has site Y1045 phosphorylated [Da00UU] ↔ [Da10UU];   {Da00UU}
 
 Da00UU has site Y1068/Y1086 phosphorylated [Da00UU] ↔ [Da01UU];   {Da00UU}
 
 Da10UU has site Y1068/Y1086 phosphorylated [Da10UU] ↔ [Da11UU];   {Da10UU}
 
 Da10CU has site Y1068/Y1086 phosphorylated [Da10CU] ↔ [Da11CU];   {Da10CU}
 
 Da10LU has site Y1068/Y1086 phosphorylated [Da10LU] ↔ [Da11LU];   {Da10LU}
 
 Da01UU has site Y1045 phosphorylated [Da01UU] ↔ [Da11UU];   {Da01UU}
 
 Da01UU has site Y1068/Y1086 phosphorylated [Da01UU] ↔ [Da02UU];   {Da01UU}
 
 Da01UG has site Y1045 phosphorylated [Da01UG] ↔ [Da11UG];   {Da01UG}
 
 Da01UG has site Y1068/Y1086 phosphorylated [Da01UG] ↔ [Da02UG];   {Da01UG}
 
 Da01UL has site Y1045 phosphorylated [Da01UL] ↔ [Da11UL];   {Da01UL}
 
 Da01UL has site Y1068/Y1086 phosphorylated [Da01UL] ↔ [Da02UL];   {Da01UL}
 
 Da11UU has site Y1068/Y1086 phosphorylated [Da11UU] ↔ [Da12UU];   {Da11UU}
 
 Da11CU has site Y1068/Y1086 phosphorylated [Da11CU] ↔ [Da12CU];   {Da11CU}
 
 Da11LU has site Y1068/Y1086 phosphorylated [Da11LU] ↔ [Da12LU];   {Da11LU}
 
 Da11UG has site Y1068/Y1086 phosphorylated [Da11UG] ↔ [Da12UG];   {Da11UG}
 
 Da11UL has site Y1068/Y1086 phosphorylated [Da11UL] ↔ [Da12UL];   {Da11UL}
 
 Da11CG has site Y1068/Y1086 phosphorylated [Da11CG] ↔ [Da12CG];   {Da11CG}
 
 Da11CC has site Y1068/Y1086 phosphorylated [Da11CC] ↔ [Da12CC];   {Da11CC}
 
 Da11LG has site Y1068/Y1086 phosphorylated [Da11LG] ↔ [Da12LG];   {Da11LG}
 
 Da02UU has site Y1045 phosphorylated [Da02UU] ↔ [Da12UU];   {Da02UU}
 
 Da02UG has site Y1045 phosphorylated [Da02UG] ↔ [Da12UG];   {Da02UG}
 
 Da02UL has site Y1045 phosphorylated [Da02UL] ↔ [Da12UL];   {Da02UL}
 
 DaL00UU has site Y1045 phosphorylated [DaL00UU] ↔ [DaL10UU];   {DaL00UU}
 
 DaL00UU has site Y1068/Y1086 phosphorylated [DaL00UU] ↔ [DaL01UU];   {DaL00UU}
 
 DaL10UU has site Y1068/Y1086 phosphorylated [DaL10UU] ↔ [DaL11UU];   {DaL10UU}
 
 DaL10CU has site Y1068/Y1086 phosphorylated [DaL10CU] ↔ [DaL11CU];   {DaL10CU}
 
 DaL10LU has site Y1068/Y1086 phosphorylated [DaL10LU] ↔ [DaL11LU];   {DaL10LU}
 
 DaL01UU has site Y1045 phosphorylated [DaL01UU] ↔ [DaL11UU];   {DaL01UU}
 
 DaL01UU has site Y1068/Y1086 phosphorylated [DaL01UU] ↔ [DaL02UU];   {DaL01UU}
 
 DaL01UG has site Y1045 phosphorylated [DaL01UG] ↔ [DaL11UG];   {DaL01UG}
 
 DaL01UG has site Y1068/Y1086 phosphorylated [DaL01UG] ↔ [DaL02UG];   {DaL01UG}
 
 DaL01UL has site Y1045 phosphorylated [DaL01UL] ↔ [DaL11UL];   {DaL01UL}
 
 DaL01UL has site Y1068/Y1086 phosphorylated [DaL01UL] ↔ [DaL02UL];   {DaL01UL}
 
 DaL11UU has site Y1068/Y1086 phosphorylated [DaL11UU] ↔ [DaL12UU];   {DaL11UU}
 
 DaL11CU has site Y1068/Y1086 phosphorylated [DaL11CU] ↔ [DaL12CU];   {DaL11CU}
 
 DaL11LU has site Y1068/Y1086 phosphorylated [DaL11LU] ↔ [DaL12LU];   {DaL11LU}
 
 DaL11UG has site Y1068/Y1086 phosphorylated [DaL11UG] ↔ [DaL12UG];   {DaL11UG}
 
 DaL11UL has site Y1068/Y1086 phosphorylated [DaL11UL] ↔ [DaL12UL];   {DaL11UL}
 
 DaL11CG has site Y1068/Y1086 phosphorylated [DaL11CG] ↔ [DaL12CG];   {DaL11CG}
 
 DaL11CC has site Y1068/Y1086 phosphorylated [DaL11CC] ↔ [DaL12CC];   {DaL11CC}
 
 DaL11LG has site Y1068/Y1086 phosphorylated [DaL11LG] ↔ [DaL12LG];   {DaL11LG}
 
 DaL02UU has site Y1045 phosphorylated [DaL02UU] ↔ [DaL12UU];   {DaL02UU}
 
 DaL02UG has site Y1045 phosphorylated [DaL02UG] ↔ [DaL12UG];   {DaL02UG}
 
 DaL02UL has site Y1045 phosphorylated [DaL02UL] ↔ [DaL12UL];   {DaL02UL}
 
 Cbl and Grb2 bind yielding CG [Cbl] + [Grb2] ↔ [CG];   {Cbl} , {Grb2}
 
 CG dissociates to Cbl and Grb2 [CG] ↔ [Cbl] + [Grb2];   {CG}
 
 Cbl and Rc10UU bind yielding Rc10CU [Cbl] + [Rc10UU] ↔ [Rc10CU];   {Cbl} , {Rc10UU}
 
 Rc10CU dissociates to Cbl and Rc10UU [Rc10CU] ↔ [Cbl] + [Rc10UU];   {Rc10CU}
 
 CG and Rc10UU bind yielding Rc10LU [CG] + [Rc10UU] ↔ [Rc10LU];   {CG} , {Rc10UU}
 
 Rc10LU dissociates to CG and Rc10UU [Rc10LU] ↔ [CG] + [Rc10UU];   {Rc10LU}
 
 Grb2 and Rc10CU bind yielding Rc10LU [Grb2] + [Rc10CU] ↔ [Rc10LU];   {Grb2} , {Rc10CU}
 
 Rc10LU dissociates to Grb2 and Rc10CU [Rc10LU] ↔ [Grb2] + [Rc10CU];   {Rc10LU}
 
 Grb2 and Rc01UU bind yielding Rc01UG [Grb2] + [Rc01UU] ↔ [Rc01UG];   {Grb2} , {Rc01UU}
 
 Rc01UG dissociates to Grb2 and Rc01UU [Rc01UG] ↔ [Grb2] + [Rc01UU];   {Rc01UG}
 
 CG and Rc01UU bind yielding Rc01UL [CG] + [Rc01UU] ↔ [Rc01UL];   {CG} , {Rc01UU}
 
 Rc01UL dissociates to CG and Rc01UU [Rc01UL] ↔ [CG] + [Rc01UU];   {Rc01UL}
 
 Cbl and Rc01UG bind yielding Rc01UL [Cbl] + [Rc01UG] ↔ [Rc01UL];   {Cbl} , {Rc01UG}
 
 Rc01UL dissociates to Cbl and Rc01UG [Rc01UL] ↔ [Cbl] + [Rc01UG];   {Rc01UL}
 
 Cbl and Rc11UU bind yielding Rc11CU [Cbl] + [Rc11UU] ↔ [Rc11CU];   {Cbl} , {Rc11UU}
 
 Rc11CU dissociates to Cbl and Rc11UU [Rc11CU] ↔ [Cbl] + [Rc11UU];   {Rc11CU}
 
 CG and Rc11UU bind yielding Rc11LU [CG] + [Rc11UU] ↔ [Rc11LU];   {CG} , {Rc11UU}
 
 Rc11LU dissociates to CG and Rc11UU [Rc11LU] ↔ [CG] + [Rc11UU];   {Rc11LU}
 
 Grb2 and Rc11UU bind yielding Rc11UG [Grb2] + [Rc11UU] ↔ [Rc11UG];   {Grb2} , {Rc11UU}
 
 Rc11UG dissociates to Grb2 and Rc11UU [Rc11UG] ↔ [Grb2] + [Rc11UU];   {Rc11UG}
 
 CG and Rc11UU bind yielding Rc11UL [CG] + [Rc11UU] ↔ [Rc11UL];   {CG} , {Rc11UU}
 
 Rc11UL dissociates to CG and Rc11UU [Rc11UL] ↔ [CG] + [Rc11UU];   {Rc11UL}
 
 Grb2 and Rc11CU bind yielding Rc11LU [Grb2] + [Rc11CU] ↔ [Rc11LU];   {Grb2} , {Rc11CU}
 
 Rc11LU dissociates to Grb2 and Rc11CU [Rc11LU] ↔ [Grb2] + [Rc11CU];   {Rc11LU}
 
 Grb2 and Rc11CU bind yielding Rc11CG [Grb2] + [Rc11CU] ↔ [Rc11CG];   {Grb2} , {Rc11CU}
 
 Rc11CG dissociates to Grb2 and Rc11CU [Rc11CG] ↔ [Grb2] + [Rc11CU];   {Rc11CG}
 
 Grb2 and Rc11LU bind yielding Rc11LG [Grb2] + [Rc11LU] ↔ [Rc11LG];   {Grb2} , {Rc11LU}
 
 Rc11LG dissociates to Grb2 and Rc11LU [Rc11LG] ↔ [Grb2] + [Rc11LU];   {Rc11LG}
 
 Rc11LU transforms in (singly-bound -> doubly-bound) Rc11CC [Rc11LU] ↔ [Rc11CC];   {Rc11LU}
 
 Rc11CC tranforms in (doubly-bound -> singly-bound) Rc11LU [Rc11CC] ↔ [Rc11LU];   {Rc11CC}
 
 Cbl and Rc11UG bind yielding Rc11CG [Cbl] + [Rc11UG] ↔ [Rc11CG];   {Cbl} , {Rc11UG}
 
 Rc11CG dissociates to Cbl and Rc11UG [Rc11CG] ↔ [Cbl] + [Rc11UG];   {Rc11CG}
 
 CG and Rc11UG bind yielding Rc11LG [CG] + [Rc11UG] ↔ [Rc11LG];   {CG} , {Rc11UG}
 
 Rc11LG dissociates to CG and Rc11UG [Rc11LG] ↔ [CG] + [Rc11UG];   {Rc11LG}
 
 Cbl and Rc11UG bind yielding Rc11UL [Cbl] + [Rc11UG] ↔ [Rc11UL];   {Cbl} , {Rc11UG}
 
 Rc11UL dissociates to Cbl and Rc11UG [Rc11UL] ↔ [Cbl] + [Rc11UG];   {Rc11UL}
 
 Rc11UL transforms in (singly-bound -> doubly-bound) Rc11CC [Rc11UL] ↔ [Rc11CC];   {Rc11UL}
 
 Rc11CC tranforms in (doubly-bound -> singly-bound) Rc11UL [Rc11CC] ↔ [Rc11UL];   {Rc11CC}
 
 Rc11CG transforms in (Cbl bind Grb2 directly) Rc11CC [Rc11CG] ↔ [Rc11CC];   {Rc11CG}
 
 Rc11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Rc11CG [Rc11CC] ↔ [Rc11CG];   {Rc11CC}
 
 Grb2 and Rc11CG bind yielding Rc11LG [Grb2] + [Rc11CG] ↔ [Rc11LG];   {Grb2} , {Rc11CG}
 
 Rc11LG dissociates to Grb2 and Rc11CG [Rc11LG] ↔ [Grb2] + [Rc11CG];   {Rc11LG}
 
 Grb2 and Rc02UU bind yielding Rc02UG [Grb2] + [Rc02UU] ↔ [Rc02UG];   {Grb2} , {Rc02UU}
 
 Rc02UG dissociates to Grb2 and Rc02UU [Rc02UG] ↔ [Grb2] + [Rc02UU];   {Rc02UG}
 
 CG and Rc02UU bind yielding Rc02UL [CG] + [Rc02UU] ↔ [Rc02UL];   {CG} , {Rc02UU}
 
 Rc02UL dissociates to CG and Rc02UU [Rc02UL] ↔ [CG] + [Rc02UU];   {Rc02UL}
 
 Cbl and Rc02UG bind yielding Rc02UL [Cbl] + [Rc02UG] ↔ [Rc02UL];   {Cbl} , {Rc02UG}
 
 Rc02UL dissociates to Cbl and Rc02UG [Rc02UL] ↔ [Cbl] + [Rc02UG];   {Rc02UL}
 
 Cbl and Rc12UU bind yielding Rc12CU [Cbl] + [Rc12UU] ↔ [Rc12CU];   {Cbl} , {Rc12UU}
 
 Rc12CU dissociates to Cbl and Rc12UU [Rc12CU] ↔ [Cbl] + [Rc12UU];   {Rc12CU}
 
 CG and Rc12UU bind yielding Rc12LU [CG] + [Rc12UU] ↔ [Rc12LU];   {CG} , {Rc12UU}
 
 Rc12LU dissociates to CG and Rc12UU [Rc12LU] ↔ [CG] + [Rc12UU];   {Rc12LU}
 
 Grb2 and Rc12UU bind yielding Rc12UG [Grb2] + [Rc12UU] ↔ [Rc12UG];   {Grb2} , {Rc12UU}
 
 Rc12UG dissociates to Grb2 and Rc12UU [Rc12UG] ↔ [Grb2] + [Rc12UU];   {Rc12UG}
 
 CG and Rc12UU bind yielding Rc12UL [CG] + [Rc12UU] ↔ [Rc12UL];   {CG} , {Rc12UU}
 
 Rc12UL dissociates to CG and Rc12UU [Rc12UL] ↔ [CG] + [Rc12UU];   {Rc12UL}
 
 Grb2 and Rc12CU bind yielding Rc12LU [Grb2] + [Rc12CU] ↔ [Rc12LU];   {Grb2} , {Rc12CU}
 
 Rc12LU dissociates to Grb2 and Rc12CU [Rc12LU] ↔ [Grb2] + [Rc12CU];   {Rc12LU}
 
 Grb2 and Rc12CU bind yielding Rc12CG [Grb2] + [Rc12CU] ↔ [Rc12CG];   {Grb2} , {Rc12CU}
 
 Rc12CG dissociates to Grb2 and Rc12CU [Rc12CG] ↔ [Grb2] + [Rc12CU];   {Rc12CG}
 
 Grb2 and Rc12LU bind yielding Rc12LG [Grb2] + [Rc12LU] ↔ [Rc12LG];   {Grb2} , {Rc12LU}
 
 Rc12LG dissociates to Grb2 and Rc12LU [Rc12LG] ↔ [Grb2] + [Rc12LU];   {Rc12LG}
 
 Rc12LU transforms in (singly-bound -> doubly-bound) Rc12CC [Rc12LU] ↔ [Rc12CC];   {Rc12LU}
 
 Rc12CC tranforms in (doubly-bound -> singly-bound) Rc12LU [Rc12CC] ↔ [Rc12LU];   {Rc12CC}
 
 Cbl and Rc12UG bind yielding Rc12CG [Cbl] + [Rc12UG] ↔ [Rc12CG];   {Cbl} , {Rc12UG}
 
 Rc12CG dissociates to Cbl and Rc12UG [Rc12CG] ↔ [Cbl] + [Rc12UG];   {Rc12CG}
 
 CG and Rc12UG bind yielding Rc12LG [CG] + [Rc12UG] ↔ [Rc12LG];   {CG} , {Rc12UG}
 
 Rc12LG dissociates to CG and Rc12UG [Rc12LG] ↔ [CG] + [Rc12UG];   {Rc12LG}
 
 Cbl and Rc12UG bind yielding Rc12UL [Cbl] + [Rc12UG] ↔ [Rc12UL];   {Cbl} , {Rc12UG}
 
 Rc12UL dissociates to Cbl and Rc12UG [Rc12UL] ↔ [Cbl] + [Rc12UG];   {Rc12UL}
 
 Rc12UL transforms in (singly-bound -> doubly-bound) Rc12CC [Rc12UL] ↔ [Rc12CC];   {Rc12UL}
 
 Rc12CC tranforms in (doubly-bound -> singly-bound) Rc12UL [Rc12CC] ↔ [Rc12UL];   {Rc12CC}
 
 Rc12CG transforms in (Cbl bind Grb2 directly) Rc12CC [Rc12CG] ↔ [Rc12CC];   {Rc12CG}
 
 Rc12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Rc12CG [Rc12CC] ↔ [Rc12CG];   {Rc12CC}
 
 Grb2 and Rc12CG bind yielding Rc12LG [Grb2] + [Rc12CG] ↔ [Rc12LG];   {Grb2} , {Rc12CG}
 
 Rc12LG dissociates to Grb2 and Rc12CG [Rc12LG] ↔ [Grb2] + [Rc12CG];   {Rc12LG}
 
 Cbl and RcL10UU bind yielding RcL10CU [Cbl] + [RcL10UU] ↔ [RcL10CU];   {Cbl} , {RcL10UU}
 
 RcL10CU dissociates to Cbl and RcL10UU [RcL10CU] ↔ [Cbl] + [RcL10UU];   {RcL10CU}
 
 CG and RcL10UU bind yielding RcL10LU [CG] + [RcL10UU] ↔ [RcL10LU];   {CG} , {RcL10UU}
 
 RcL10LU dissociates to CG and RcL10UU [RcL10LU] ↔ [CG] + [RcL10UU];   {RcL10LU}
 
 Grb2 and RcL10CU bind yielding RcL10LU [Grb2] + [RcL10CU] ↔ [RcL10LU];   {Grb2} , {RcL10CU}
 
 RcL10LU dissociates to Grb2 and RcL10CU [RcL10LU] ↔ [Grb2] + [RcL10CU];   {RcL10LU}
 
 Grb2 and RcL01UU bind yielding RcL01UG [Grb2] + [RcL01UU] ↔ [RcL01UG];   {Grb2} , {RcL01UU}
 
 RcL01UG dissociates to Grb2 and RcL01UU [RcL01UG] ↔ [Grb2] + [RcL01UU];   {RcL01UG}
 
 CG and RcL01UU bind yielding RcL01UL [CG] + [RcL01UU] ↔ [RcL01UL];   {CG} , {RcL01UU}
 
 RcL01UL dissociates to CG and RcL01UU [RcL01UL] ↔ [CG] + [RcL01UU];   {RcL01UL}
 
 Cbl and RcL01UG bind yielding RcL01UL [Cbl] + [RcL01UG] ↔ [RcL01UL];   {Cbl} , {RcL01UG}
 
 RcL01UL dissociates to Cbl and RcL01UG [RcL01UL] ↔ [Cbl] + [RcL01UG];   {RcL01UL}
 
 Cbl and RcL11UU bind yielding RcL11CU [Cbl] + [RcL11UU] ↔ [RcL11CU];   {Cbl} , {RcL11UU}
 
 RcL11CU dissociates to Cbl and RcL11UU [RcL11CU] ↔ [Cbl] + [RcL11UU];   {RcL11CU}
 
 CG and RcL11UU bind yielding RcL11LU [CG] + [RcL11UU] ↔ [RcL11LU];   {CG} , {RcL11UU}
 
 RcL11LU dissociates to CG and RcL11UU [RcL11LU] ↔ [CG] + [RcL11UU];   {RcL11LU}
 
 Grb2 and RcL11UU bind yielding RcL11UG [Grb2] + [RcL11UU] ↔ [RcL11UG];   {Grb2} , {RcL11UU}
 
 RcL11UG dissociates to Grb2 and RcL11UU [RcL11UG] ↔ [Grb2] + [RcL11UU];   {RcL11UG}
 
 CG and RcL11UU bind yielding RcL11UL [CG] + [RcL11UU] ↔ [RcL11UL];   {CG} , {RcL11UU}
 
 RcL11UL dissociates to CG and RcL11UU [RcL11UL] ↔ [CG] + [RcL11UU];   {RcL11UL}
 
 Grb2 and RcL11CU bind yielding RcL11LU [Grb2] + [RcL11CU] ↔ [RcL11LU];   {Grb2} , {RcL11CU}
 
 RcL11LU dissociates to Grb2 and RcL11CU [RcL11LU] ↔ [Grb2] + [RcL11CU];   {RcL11LU}
 
 Grb2 and RcL11CU bind yielding RcL11CG [Grb2] + [RcL11CU] ↔ [RcL11CG];   {Grb2} , {RcL11CU}
 
 RcL11CG dissociates to Grb2 and RcL11CU [RcL11CG] ↔ [Grb2] + [RcL11CU];   {RcL11CG}
 
 Grb2 and RcL11LU bind yielding RcL11LG [Grb2] + [RcL11LU] ↔ [RcL11LG];   {Grb2} , {RcL11LU}
 
 RcL11LG dissociates to Grb2 and RcL11LU [RcL11LG] ↔ [Grb2] + [RcL11LU];   {RcL11LG}
 
 RcL11LU transforms in (singly-bound -> doubly-bound) RcL11CC [RcL11LU] ↔ [RcL11CC];   {RcL11LU}
 
 RcL11CC tranforms in (doubly-bound -> singly-bound) RcL11LU [RcL11CC] ↔ [RcL11LU];   {RcL11CC}
 
 Cbl and RcL11UG bind yielding RcL11CG [Cbl] + [RcL11UG] ↔ [RcL11CG];   {Cbl} , {RcL11UG}
 
 RcL11CG dissociates to Cbl and RcL11UG [RcL11CG] ↔ [Cbl] + [RcL11UG];   {RcL11CG}
 
 CG and RcL11UG bind yielding RcL11LG [CG] + [RcL11UG] ↔ [RcL11LG];   {CG} , {RcL11UG}
 
 RcL11LG dissociates to CG and RcL11UG [RcL11LG] ↔ [CG] + [RcL11UG];   {RcL11LG}
 
 Cbl and RcL11UG bind yielding RcL11UL [Cbl] + [RcL11UG] ↔ [RcL11UL];   {Cbl} , {RcL11UG}
 
 RcL11UL dissociates to Cbl and RcL11UG [RcL11UL] ↔ [Cbl] + [RcL11UG];   {RcL11UL}
 
 RcL11UL transforms in (singly-bound -> doubly-bound) RcL11CC [RcL11UL] ↔ [RcL11CC];   {RcL11UL}
 
 RcL11CC tranforms in (doubly-bound -> singly-bound) RcL11UL [RcL11CC] ↔ [RcL11UL];   {RcL11CC}
 
 RcL11CG transforms in (Cbl bind Grb2 directly) RcL11CC [RcL11CG] ↔ [RcL11CC];   {RcL11CG}
 
 RcL11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) RcL11CG [RcL11CC] ↔ [RcL11CG];   {RcL11CC}
 
 Grb2 and RcL11CG bind yielding RcL11LG [Grb2] + [RcL11CG] ↔ [RcL11LG];   {Grb2} , {RcL11CG}
 
 RcL11LG dissociates to Grb2 and RcL11CG [RcL11LG] ↔ [Grb2] + [RcL11CG];   {RcL11LG}
 
 Grb2 and RcL02UU bind yielding RcL02UG [Grb2] + [RcL02UU] ↔ [RcL02UG];   {Grb2} , {RcL02UU}
 
 RcL02UG dissociates to Grb2 and RcL02UU [RcL02UG] ↔ [Grb2] + [RcL02UU];   {RcL02UG}
 
 CG and RcL02UU bind yielding RcL02UL [CG] + [RcL02UU] ↔ [RcL02UL];   {CG} , {RcL02UU}
 
 RcL02UL dissociates to CG and RcL02UU [RcL02UL] ↔ [CG] + [RcL02UU];   {RcL02UL}
 
 Cbl and RcL02UG bind yielding RcL02UL [Cbl] + [RcL02UG] ↔ [RcL02UL];   {Cbl} , {RcL02UG}
 
 RcL02UL dissociates to Cbl and RcL02UG [RcL02UL] ↔ [Cbl] + [RcL02UG];   {RcL02UL}
 
 Cbl and RcL12UU bind yielding RcL12CU [Cbl] + [RcL12UU] ↔ [RcL12CU];   {Cbl} , {RcL12UU}
 
 RcL12CU dissociates to Cbl and RcL12UU [RcL12CU] ↔ [Cbl] + [RcL12UU];   {RcL12CU}
 
 CG and RcL12UU bind yielding RcL12LU [CG] + [RcL12UU] ↔ [RcL12LU];   {CG} , {RcL12UU}
 
 RcL12LU dissociates to CG and RcL12UU [RcL12LU] ↔ [CG] + [RcL12UU];   {RcL12LU}
 
 Grb2 and RcL12UU bind yielding RcL12UG [Grb2] + [RcL12UU] ↔ [RcL12UG];   {Grb2} , {RcL12UU}
 
 RcL12UG dissociates to Grb2 and RcL12UU [RcL12UG] ↔ [Grb2] + [RcL12UU];   {RcL12UG}
 
 CG and RcL12UU bind yielding RcL12UL [CG] + [RcL12UU] ↔ [RcL12UL];   {CG} , {RcL12UU}
 
 RcL12UL dissociates to CG and RcL12UU [RcL12UL] ↔ [CG] + [RcL12UU];   {RcL12UL}
 
 Grb2 and RcL12CU bind yielding RcL12LU [Grb2] + [RcL12CU] ↔ [RcL12LU];   {Grb2} , {RcL12CU}
 
 RcL12LU dissociates to Grb2 and RcL12CU [RcL12LU] ↔ [Grb2] + [RcL12CU];   {RcL12LU}
 
 Grb2 and RcL12CU bind yielding RcL12CG [Grb2] + [RcL12CU] ↔ [RcL12CG];   {Grb2} , {RcL12CU}
 
 RcL12CG dissociates to Grb2 and RcL12CU [RcL12CG] ↔ [Grb2] + [RcL12CU];   {RcL12CG}
 
 Grb2 and RcL12LU bind yielding RcL12LG [Grb2] + [RcL12LU] ↔ [RcL12LG];   {Grb2} , {RcL12LU}
 
 RcL12LG dissociates to Grb2 and RcL12LU [RcL12LG] ↔ [Grb2] + [RcL12LU];   {RcL12LG}
 
 RcL12LU transforms in (singly-bound -> doubly-bound) RcL12CC [RcL12LU] ↔ [RcL12CC];   {RcL12LU}
 
 RcL12CC tranforms in (doubly-bound -> singly-bound) RcL12LU [RcL12CC] ↔ [RcL12LU];   {RcL12CC}
 
 Cbl and RcL12UG bind yielding RcL12CG [Cbl] + [RcL12UG] ↔ [RcL12CG];   {Cbl} , {RcL12UG}
 
 RcL12CG dissociates to Cbl and RcL12UG [RcL12CG] ↔ [Cbl] + [RcL12UG];   {RcL12CG}
 
 CG and RcL12UG bind yielding RcL12LG [CG] + [RcL12UG] ↔ [RcL12LG];   {CG} , {RcL12UG}
 
 RcL12LG dissociates to CG and RcL12UG [RcL12LG] ↔ [CG] + [RcL12UG];   {RcL12LG}
 
 Cbl and RcL12UG bind yielding RcL12UL [Cbl] + [RcL12UG] ↔ [RcL12UL];   {Cbl} , {RcL12UG}
 
 RcL12UL dissociates to Cbl and RcL12UG [RcL12UL] ↔ [Cbl] + [RcL12UG];   {RcL12UL}
 
 RcL12UL transforms in (singly-bound -> doubly-bound) RcL12CC [RcL12UL] ↔ [RcL12CC];   {RcL12UL}
 
 RcL12CC tranforms in (doubly-bound -> singly-bound) RcL12UL [RcL12CC] ↔ [RcL12UL];   {RcL12CC}
 
 RcL12CG transforms in (Cbl bind Grb2 directly) RcL12CC [RcL12CG] ↔ [RcL12CC];   {RcL12CG}
 
 RcL12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) RcL12CG [RcL12CC] ↔ [RcL12CG];   {RcL12CC}
 
 Grb2 and RcL12CG bind yielding RcL12LG [Grb2] + [RcL12CG] ↔ [RcL12LG];   {Grb2} , {RcL12CG}
 
 RcL12LG dissociates to Grb2 and RcL12CG [RcL12LG] ↔ [Grb2] + [RcL12CG];   {RcL12LG}
 
 Cbl and R10UU bind yielding R10CU [Cbl] + [R10UU] ↔ [R10CU];   {Cbl} , {R10UU}
 
 R10CU dissociates to Cbl and R10UU [R10CU] ↔ [Cbl] + [R10UU];   {R10CU}
 
 CG and R10UU bind yielding R10LU [CG] + [R10UU] ↔ [R10LU];   {CG} , {R10UU}
 
 R10LU dissociates to CG and R10UU [R10LU] ↔ [CG] + [R10UU];   {R10LU}
 
 Grb2 and R10CU bind yielding R10LU [Grb2] + [R10CU] ↔ [R10LU];   {Grb2} , {R10CU}
 
 R10LU dissociates to Grb2 and R10CU [R10LU] ↔ [Grb2] + [R10CU];   {R10LU}
 
 Grb2 and R01UU bind yielding R01UG [Grb2] + [R01UU] ↔ [R01UG];   {Grb2} , {R01UU}
 
 R01UG dissociates to Grb2 and R01UU [R01UG] ↔ [Grb2] + [R01UU];   {R01UG}
 
 CG and R01UU bind yielding R01UL [CG] + [R01UU] ↔ [R01UL];   {CG} , {R01UU}
 
 R01UL dissociates to CG and R01UU [R01UL] ↔ [CG] + [R01UU];   {R01UL}
 
 Cbl and R01UG bind yielding R01UL [Cbl] + [R01UG] ↔ [R01UL];   {Cbl} , {R01UG}
 
 R01UL dissociates to Cbl and R01UG [R01UL] ↔ [Cbl] + [R01UG];   {R01UL}
 
 Cbl and R11UU bind yielding R11CU [Cbl] + [R11UU] ↔ [R11CU];   {Cbl} , {R11UU}
 
 R11CU dissociates to Cbl and R11UU [R11CU] ↔ [Cbl] + [R11UU];   {R11CU}
 
 CG and R11UU bind yielding R11LU [CG] + [R11UU] ↔ [R11LU];   {CG} , {R11UU}
 
 R11LU dissociates to CG and R11UU [R11LU] ↔ [CG] + [R11UU];   {R11LU}
 
 Grb2 and R11UU bind yielding R11UG [Grb2] + [R11UU] ↔ [R11UG];   {Grb2} , {R11UU}
 
 R11UG dissociates to Grb2 and R11UU [R11UG] ↔ [Grb2] + [R11UU];   {R11UG}
 
 CG and R11UU bind yielding R11UL [CG] + [R11UU] ↔ [R11UL];   {CG} , {R11UU}
 
 R11UL dissociates to CG and R11UU [R11UL] ↔ [CG] + [R11UU];   {R11UL}
 
 Grb2 and R11CU bind yielding R11LU [Grb2] + [R11CU] ↔ [R11LU];   {Grb2} , {R11CU}
 
 R11LU dissociates to Grb2 and R11CU [R11LU] ↔ [Grb2] + [R11CU];   {R11LU}
 
 Grb2 and R11CU bind yielding R11CG [Grb2] + [R11CU] ↔ [R11CG];   {Grb2} , {R11CU}
 
 R11CG dissociates to Grb2 and R11CU [R11CG] ↔ [Grb2] + [R11CU];   {R11CG}
 
 Grb2 and R11LU bind yielding R11LG [Grb2] + [R11LU] ↔ [R11LG];   {Grb2} , {R11LU}
 
 R11LG dissociates to Grb2 and R11LU [R11LG] ↔ [Grb2] + [R11LU];   {R11LG}
 
 R11LU transforms in (singly-bound -> doubly-bound) R11CC [R11LU] ↔ [R11CC];   {R11LU}
 
 R11CC tranforms in (doubly-bound -> singly-bound) R11LU [R11CC] ↔ [R11LU];   {R11CC}
 
 Cbl and R11UG bind yielding R11CG [Cbl] + [R11UG] ↔ [R11CG];   {Cbl} , {R11UG}
 
 R11CG dissociates to Cbl and R11UG [R11CG] ↔ [Cbl] + [R11UG];   {R11CG}
 
 CG and R11UG bind yielding R11LG [CG] + [R11UG] ↔ [R11LG];   {CG} , {R11UG}
 
 R11LG dissociates to CG and R11UG [R11LG] ↔ [CG] + [R11UG];   {R11LG}
 
 Cbl and R11UG bind yielding R11UL [Cbl] + [R11UG] ↔ [R11UL];   {Cbl} , {R11UG}
 
 R11UL dissociates to Cbl and R11UG [R11UL] ↔ [Cbl] + [R11UG];   {R11UL}
 
 R11UL transforms in (singly-bound -> doubly-bound) R11CC [R11UL] ↔ [R11CC];   {R11UL}
 
 R11CC tranforms in (doubly-bound -> singly-bound) R11UL [R11CC] ↔ [R11UL];   {R11CC}
 
 R11CG transforms in (Cbl bind Grb2 directly) R11CC [R11CG] ↔ [R11CC];   {R11CG}
 
 R11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) R11CG [R11CC] ↔ [R11CG];   {R11CC}
 
 Grb2 and R11CG bind yielding R11LG [Grb2] + [R11CG] ↔ [R11LG];   {Grb2} , {R11CG}
 
 R11LG dissociates to Grb2 and R11CG [R11LG] ↔ [Grb2] + [R11CG];   {R11LG}
 
 Grb2 and R02UU bind yielding R02UG [Grb2] + [R02UU] ↔ [R02UG];   {Grb2} , {R02UU}
 
 R02UG dissociates to Grb2 and R02UU [R02UG] ↔ [Grb2] + [R02UU];   {R02UG}
 
 CG and R02UU bind yielding R02UL [CG] + [R02UU] ↔ [R02UL];   {CG} , {R02UU}
 
 R02UL dissociates to CG and R02UU [R02UL] ↔ [CG] + [R02UU];   {R02UL}
 
 Cbl and R02UG bind yielding R02UL [Cbl] + [R02UG] ↔ [R02UL];   {Cbl} , {R02UG}
 
 R02UL dissociates to Cbl and R02UG [R02UL] ↔ [Cbl] + [R02UG];   {R02UL}
 
 Cbl and R12UU bind yielding R12CU [Cbl] + [R12UU] ↔ [R12CU];   {Cbl} , {R12UU}
 
 R12CU dissociates to Cbl and R12UU [R12CU] ↔ [Cbl] + [R12UU];   {R12CU}
 
 CG and R12UU bind yielding R12LU [CG] + [R12UU] ↔ [R12LU];   {CG} , {R12UU}
 
 R12LU dissociates to CG and R12UU [R12LU] ↔ [CG] + [R12UU];   {R12LU}
 
 Grb2 and R12UU bind yielding R12UG [Grb2] + [R12UU] ↔ [R12UG];   {Grb2} , {R12UU}
 
 R12UG dissociates to Grb2 and R12UU [R12UG] ↔ [Grb2] + [R12UU];   {R12UG}
 
 CG and R12UU bind yielding R12UL [CG] + [R12UU] ↔ [R12UL];   {CG} , {R12UU}
 
 R12UL dissociates to CG and R12UU [R12UL] ↔ [CG] + [R12UU];   {R12UL}
 
 Grb2 and R12CU bind yielding R12LU [Grb2] + [R12CU] ↔ [R12LU];   {Grb2} , {R12CU}
 
 R12LU dissociates to Grb2 and R12CU [R12LU] ↔ [Grb2] + [R12CU];   {R12LU}
 
 Grb2 and R12CU bind yielding R12CG [Grb2] + [R12CU] ↔ [R12CG];   {Grb2} , {R12CU}
 
 R12CG dissociates to Grb2 and R12CU [R12CG] ↔ [Grb2] + [R12CU];   {R12CG}
 
 Grb2 and R12LU bind yielding R12LG [Grb2] + [R12LU] ↔ [R12LG];   {Grb2} , {R12LU}
 
 R12LG dissociates to Grb2 and R12LU [R12LG] ↔ [Grb2] + [R12LU];   {R12LG}
 
 R12LU transforms in (singly-bound -> doubly-bound) R12CC [R12LU] ↔ [R12CC];   {R12LU}
 
 R12CC tranforms in (doubly-bound -> singly-bound) R12LU [R12CC] ↔ [R12LU];   {R12CC}
 
 Cbl and R12UG bind yielding R12CG [Cbl] + [R12UG] ↔ [R12CG];   {Cbl} , {R12UG}
 
 R12CG dissociates to Cbl and R12UG [R12CG] ↔ [Cbl] + [R12UG];   {R12CG}
 
 CG and R12UG bind yielding R12LG [CG] + [R12UG] ↔ [R12LG];   {CG} , {R12UG}
 
 R12LG dissociates to CG and R12UG [R12LG] ↔ [CG] + [R12UG];   {R12LG}
 
 Cbl and R12UG bind yielding R12UL [Cbl] + [R12UG] ↔ [R12UL];   {Cbl} , {R12UG}
 
 R12UL dissociates to Cbl and R12UG [R12UL] ↔ [Cbl] + [R12UG];   {R12UL}
 
 R12UL transforms in (singly-bound -> doubly-bound) R12CC [R12UL] ↔ [R12CC];   {R12UL}
 
 R12CC tranforms in (doubly-bound -> singly-bound) R12UL [R12CC] ↔ [R12UL];   {R12CC}
 
 R12CG transforms in (Cbl bind Grb2 directly) R12CC [R12CG] ↔ [R12CC];   {R12CG}
 
 R12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) R12CG [R12CC] ↔ [R12CG];   {R12CC}
 
 Grb2 and R12CG bind yielding R12LG [Grb2] + [R12CG] ↔ [R12LG];   {Grb2} , {R12CG}
 
 R12LG dissociates to Grb2 and R12CG [R12LG] ↔ [Grb2] + [R12CG];   {R12LG}
 
 Cbl and RL10UU bind yielding RL10CU [Cbl] + [RL10UU] ↔ [RL10CU];   {Cbl} , {RL10UU}
 
 RL10CU dissociates to Cbl and RL10UU [RL10CU] ↔ [Cbl] + [RL10UU];   {RL10CU}
 
 CG and RL10UU bind yielding RL10LU [CG] + [RL10UU] ↔ [RL10LU];   {CG} , {RL10UU}
 
 RL10LU dissociates to CG and RL10UU [RL10LU] ↔ [CG] + [RL10UU];   {RL10LU}
 
 Grb2 and RL10CU bind yielding RL10LU [Grb2] + [RL10CU] ↔ [RL10LU];   {Grb2} , {RL10CU}
 
 RL10LU dissociates to Grb2 and RL10CU [RL10LU] ↔ [Grb2] + [RL10CU];   {RL10LU}
 
 Grb2 and RL01UU bind yielding RL01UG [Grb2] + [RL01UU] ↔ [RL01UG];   {Grb2} , {RL01UU}
 
 RL01UG dissociates to Grb2 and RL01UU [RL01UG] ↔ [Grb2] + [RL01UU];   {RL01UG}
 
 CG and RL01UU bind yielding RL01UL [CG] + [RL01UU] ↔ [RL01UL];   {CG} , {RL01UU}
 
 RL01UL dissociates to CG and RL01UU [RL01UL] ↔ [CG] + [RL01UU];   {RL01UL}
 
 Cbl and RL01UG bind yielding RL01UL [Cbl] + [RL01UG] ↔ [RL01UL];   {Cbl} , {RL01UG}
 
 RL01UL dissociates to Cbl and RL01UG [RL01UL] ↔ [Cbl] + [RL01UG];   {RL01UL}
 
 Cbl and RL11UU bind yielding RL11CU [Cbl] + [RL11UU] ↔ [RL11CU];   {Cbl} , {RL11UU}
 
 RL11CU dissociates to Cbl and RL11UU [RL11CU] ↔ [Cbl] + [RL11UU];   {RL11CU}
 
 CG and RL11UU bind yielding RL11LU [CG] + [RL11UU] ↔ [RL11LU];   {CG} , {RL11UU}
 
 RL11LU dissociates to CG and RL11UU [RL11LU] ↔ [CG] + [RL11UU];   {RL11LU}
 
 Grb2 and RL11UU bind yielding RL11UG [Grb2] + [RL11UU] ↔ [RL11UG];   {Grb2} , {RL11UU}
 
 RL11UG dissociates to Grb2 and RL11UU [RL11UG] ↔ [Grb2] + [RL11UU];   {RL11UG}
 
 CG and RL11UU bind yielding RL11UL [CG] + [RL11UU] ↔ [RL11UL];   {CG} , {RL11UU}
 
 RL11UL dissociates to CG and RL11UU [RL11UL] ↔ [CG] + [RL11UU];   {RL11UL}
 
 Grb2 and RL11CU bind yielding RL11LU [Grb2] + [RL11CU] ↔ [RL11LU];   {Grb2} , {RL11CU}
 
 RL11LU dissociates to Grb2 and RL11CU [RL11LU] ↔ [Grb2] + [RL11CU];   {RL11LU}
 
 Grb2 and RL11CU bind yielding RL11CG [Grb2] + [RL11CU] ↔ [RL11CG];   {Grb2} , {RL11CU}
 
 RL11CG dissociates to Grb2 and RL11CU [RL11CG] ↔ [Grb2] + [RL11CU];   {RL11CG}
 
 Grb2 and RL11LU bind yielding RL11LG [Grb2] + [RL11LU] ↔ [RL11LG];   {Grb2} , {RL11LU}
 
 RL11LG dissociates to Grb2 and RL11LU [RL11LG] ↔ [Grb2] + [RL11LU];   {RL11LG}
 
 RL11LU transforms in (singly-bound -> doubly-bound) RL11CC [RL11LU] ↔ [RL11CC];   {RL11LU}
 
 RL11CC tranforms in (doubly-bound -> singly-bound) RL11LU [RL11CC] ↔ [RL11LU];   {RL11CC}
 
 Cbl and RL11UG bind yielding RL11CG [Cbl] + [RL11UG] ↔ [RL11CG];   {Cbl} , {RL11UG}
 
 RL11CG dissociates to Cbl and RL11UG [RL11CG] ↔ [Cbl] + [RL11UG];   {RL11CG}
 
 CG and RL11UG bind yielding RL11LG [CG] + [RL11UG] ↔ [RL11LG];   {CG} , {RL11UG}
 
 RL11LG dissociates to CG and RL11UG [RL11LG] ↔ [CG] + [RL11UG];   {RL11LG}
 
 Cbl and RL11UG bind yielding RL11UL [Cbl] + [RL11UG] ↔ [RL11UL];   {Cbl} , {RL11UG}
 
 RL11UL dissociates to Cbl and RL11UG [RL11UL] ↔ [Cbl] + [RL11UG];   {RL11UL}
 
 RL11UL transforms in (singly-bound -> doubly-bound) RL11CC [RL11UL] ↔ [RL11CC];   {RL11UL}
 
 RL11CC tranforms in (doubly-bound -> singly-bound) RL11UL [RL11CC] ↔ [RL11UL];   {RL11CC}
 
 RL11CG transforms in (Cbl bind Grb2 directly) RL11CC [RL11CG] ↔ [RL11CC];   {RL11CG}
 
 RL11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) RL11CG [RL11CC] ↔ [RL11CG];   {RL11CC}
 
 Grb2 and RL11CG bind yielding RL11LG [Grb2] + [RL11CG] ↔ [RL11LG];   {Grb2} , {RL11CG}
 
 RL11LG dissociates to Grb2 and RL11CG [RL11LG] ↔ [Grb2] + [RL11CG];   {RL11LG}
 
 Grb2 and RL02UU bind yielding RL02UG [Grb2] + [RL02UU] ↔ [RL02UG];   {Grb2} , {RL02UU}
 
 RL02UG dissociates to Grb2 and RL02UU [RL02UG] ↔ [Grb2] + [RL02UU];   {RL02UG}
 
 CG and RL02UU bind yielding RL02UL [CG] + [RL02UU] ↔ [RL02UL];   {CG} , {RL02UU}
 
 RL02UL dissociates to CG and RL02UU [RL02UL] ↔ [CG] + [RL02UU];   {RL02UL}
 
 Cbl and RL02UG bind yielding RL02UL [Cbl] + [RL02UG] ↔ [RL02UL];   {Cbl} , {RL02UG}
 
 RL02UL dissociates to Cbl and RL02UG [RL02UL] ↔ [Cbl] + [RL02UG];   {RL02UL}
 
 Cbl and RL12UU bind yielding RL12CU [Cbl] + [RL12UU] ↔ [RL12CU];   {Cbl} , {RL12UU}
 
 RL12CU dissociates to Cbl and RL12UU [RL12CU] ↔ [Cbl] + [RL12UU];   {RL12CU}
 
 CG and RL12UU bind yielding RL12LU [CG] + [RL12UU] ↔ [RL12LU];   {CG} , {RL12UU}
 
 RL12LU dissociates to CG and RL12UU [RL12LU] ↔ [CG] + [RL12UU];   {RL12LU}
 
 Grb2 and RL12UU bind yielding RL12UG [Grb2] + [RL12UU] ↔ [RL12UG];   {Grb2} , {RL12UU}
 
 RL12UG dissociates to Grb2 and RL12UU [RL12UG] ↔ [Grb2] + [RL12UU];   {RL12UG}
 
 CG and RL12UU bind yielding RL12UL [CG] + [RL12UU] ↔ [RL12UL];   {CG} , {RL12UU}
 
 RL12UL dissociates to CG and RL12UU [RL12UL] ↔ [CG] + [RL12UU];   {RL12UL}
 
 Grb2 and RL12CU bind yielding RL12LU [Grb2] + [RL12CU] ↔ [RL12LU];   {Grb2} , {RL12CU}
 
 RL12LU dissociates to Grb2 and RL12CU [RL12LU] ↔ [Grb2] + [RL12CU];   {RL12LU}
 
 Grb2 and RL12CU bind yielding RL12CG [Grb2] + [RL12CU] ↔ [RL12CG];   {Grb2} , {RL12CU}
 
 RL12CG dissociates to Grb2 and RL12CU [RL12CG] ↔ [Grb2] + [RL12CU];   {RL12CG}
 
 Grb2 and RL12LU bind yielding RL12LG [Grb2] + [RL12LU] ↔ [RL12LG];   {Grb2} , {RL12LU}
 
 RL12LG dissociates to Grb2 and RL12LU [RL12LG] ↔ [Grb2] + [RL12LU];   {RL12LG}
 
 RL12LU transforms in (singly-bound -> doubly-bound) RL12CC [RL12LU] ↔ [RL12CC];   {RL12LU}
 
 RL12CC tranforms in (doubly-bound -> singly-bound) RL12LU [RL12CC] ↔ [RL12LU];   {RL12CC}
 
 Cbl and RL12UG bind yielding RL12CG [Cbl] + [RL12UG] ↔ [RL12CG];   {Cbl} , {RL12UG}
 
 RL12CG dissociates to Cbl and RL12UG [RL12CG] ↔ [Cbl] + [RL12UG];   {RL12CG}
 
 CG and RL12UG bind yielding RL12LG [CG] + [RL12UG] ↔ [RL12LG];   {CG} , {RL12UG}
 
 RL12LG dissociates to CG and RL12UG [RL12LG] ↔ [CG] + [RL12UG];   {RL12LG}
 
 Cbl and RL12UG bind yielding RL12UL [Cbl] + [RL12UG] ↔ [RL12UL];   {Cbl} , {RL12UG}
 
 RL12UL dissociates to Cbl and RL12UG [RL12UL] ↔ [Cbl] + [RL12UG];   {RL12UL}
 
 RL12UL transforms in (singly-bound -> doubly-bound) RL12CC [RL12UL] ↔ [RL12CC];   {RL12UL}
 
 RL12CC tranforms in (doubly-bound -> singly-bound) RL12UL [RL12CC] ↔ [RL12UL];   {RL12CC}
 
 RL12CG transforms in (Cbl bind Grb2 directly) RL12CC [RL12CG] ↔ [RL12CC];   {RL12CG}
 
 RL12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) RL12CG [RL12CC] ↔ [RL12CG];   {RL12CC}
 
 Grb2 and RL12CG bind yielding RL12LG [Grb2] + [RL12CG] ↔ [RL12LG];   {Grb2} , {RL12CG}
 
 RL12LG dissociates to Grb2 and RL12CG [RL12LG] ↔ [Grb2] + [RL12CG];   {RL12LG}
 
 Cbl and Di10UU bind yielding Di10CU [Cbl] + [Di10UU] ↔ [Di10CU];   {Cbl} , {Di10UU}
 
 Di10CU dissociates to Cbl and Di10UU [Di10CU] ↔ [Cbl] + [Di10UU];   {Di10CU}
 
 CG and Di10UU bind yielding Di10LU [CG] + [Di10UU] ↔ [Di10LU];   {CG} , {Di10UU}
 
 Di10LU dissociates to CG and Di10UU [Di10LU] ↔ [CG] + [Di10UU];   {Di10LU}
 
 Grb2 and Di10CU bind yielding Di10LU [Grb2] + [Di10CU] ↔ [Di10LU];   {Grb2} , {Di10CU}
 
 Di10LU dissociates to Grb2 and Di10CU [Di10LU] ↔ [Grb2] + [Di10CU];   {Di10LU}
 
 Grb2 and Di01UU bind yielding Di01UG [Grb2] + [Di01UU] ↔ [Di01UG];   {Grb2} , {Di01UU}
 
 Di01UG dissociates to Grb2 and Di01UU [Di01UG] ↔ [Grb2] + [Di01UU];   {Di01UG}
 
 CG and Di01UU bind yielding Di01UL [CG] + [Di01UU] ↔ [Di01UL];   {CG} , {Di01UU}
 
 Di01UL dissociates to CG and Di01UU [Di01UL] ↔ [CG] + [Di01UU];   {Di01UL}
 
 Cbl and Di01UG bind yielding Di01UL [Cbl] + [Di01UG] ↔ [Di01UL];   {Cbl} , {Di01UG}
 
 Di01UL dissociates to Cbl and Di01UG [Di01UL] ↔ [Cbl] + [Di01UG];   {Di01UL}
 
 Cbl and Di11UU bind yielding Di11CU [Cbl] + [Di11UU] ↔ [Di11CU];   {Cbl} , {Di11UU}
 
 Di11CU dissociates to Cbl and Di11UU [Di11CU] ↔ [Cbl] + [Di11UU];   {Di11CU}
 
 CG and Di11UU bind yielding Di11LU [CG] + [Di11UU] ↔ [Di11LU];   {CG} , {Di11UU}
 
 Di11LU dissociates to CG and Di11UU [Di11LU] ↔ [CG] + [Di11UU];   {Di11LU}
 
 Grb2 and Di11UU bind yielding Di11UG [Grb2] + [Di11UU] ↔ [Di11UG];   {Grb2} , {Di11UU}
 
 Di11UG dissociates to Grb2 and Di11UU [Di11UG] ↔ [Grb2] + [Di11UU];   {Di11UG}
 
 CG and Di11UU bind yielding Di11UL [CG] + [Di11UU] ↔ [Di11UL];   {CG} , {Di11UU}
 
 Di11UL dissociates to CG and Di11UU [Di11UL] ↔ [CG] + [Di11UU];   {Di11UL}
 
 Grb2 and Di11CU bind yielding Di11LU [Grb2] + [Di11CU] ↔ [Di11LU];   {Grb2} , {Di11CU}
 
 Di11LU dissociates to Grb2 and Di11CU [Di11LU] ↔ [Grb2] + [Di11CU];   {Di11LU}
 
 Grb2 and Di11CU bind yielding Di11CG [Grb2] + [Di11CU] ↔ [Di11CG];   {Grb2} , {Di11CU}
 
 Di11CG dissociates to Grb2 and Di11CU [Di11CG] ↔ [Grb2] + [Di11CU];   {Di11CG}
 
 Grb2 and Di11LU bind yielding Di11LG [Grb2] + [Di11LU] ↔ [Di11LG];   {Grb2} , {Di11LU}
 
 Di11LG dissociates to Grb2 and Di11LU [Di11LG] ↔ [Grb2] + [Di11LU];   {Di11LG}
 
 Di11LU transforms in (singly-bound -> doubly-bound) Di11CC [Di11LU] ↔ [Di11CC];   {Di11LU}
 
 Di11CC tranforms in (doubly-bound -> singly-bound) Di11LU [Di11CC] ↔ [Di11LU];   {Di11CC}
 
 Cbl and Di11UG bind yielding Di11CG [Cbl] + [Di11UG] ↔ [Di11CG];   {Cbl} , {Di11UG}
 
 Di11CG dissociates to Cbl and Di11UG [Di11CG] ↔ [Cbl] + [Di11UG];   {Di11CG}
 
 CG and Di11UG bind yielding Di11LG [CG] + [Di11UG] ↔ [Di11LG];   {CG} , {Di11UG}
 
 Di11LG dissociates to CG and Di11UG [Di11LG] ↔ [CG] + [Di11UG];   {Di11LG}
 
 Cbl and Di11UG bind yielding Di11UL [Cbl] + [Di11UG] ↔ [Di11UL];   {Cbl} , {Di11UG}
 
 Di11UL dissociates to Cbl and Di11UG [Di11UL] ↔ [Cbl] + [Di11UG];   {Di11UL}
 
 Di11UL transforms in (singly-bound -> doubly-bound) Di11CC [Di11UL] ↔ [Di11CC];   {Di11UL}
 
 Di11CC tranforms in (doubly-bound -> singly-bound) Di11UL [Di11CC] ↔ [Di11UL];   {Di11CC}
 
 Di11CG transforms in (Cbl bind Grb2 directly) Di11CC [Di11CG] ↔ [Di11CC];   {Di11CG}
 
 Di11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Di11CG [Di11CC] ↔ [Di11CG];   {Di11CC}
 
 Grb2 and Di11CG bind yielding Di11LG [Grb2] + [Di11CG] ↔ [Di11LG];   {Grb2} , {Di11CG}
 
 Di11LG dissociates to Grb2 and Di11CG [Di11LG] ↔ [Grb2] + [Di11CG];   {Di11LG}
 
 Grb2 and Di02UU bind yielding Di02UG [Grb2] + [Di02UU] ↔ [Di02UG];   {Grb2} , {Di02UU}
 
 Di02UG dissociates to Grb2 and Di02UU [Di02UG] ↔ [Grb2] + [Di02UU];   {Di02UG}
 
 CG and Di02UU bind yielding Di02UL [CG] + [Di02UU] ↔ [Di02UL];   {CG} , {Di02UU}
 
 Di02UL dissociates to CG and Di02UU [Di02UL] ↔ [CG] + [Di02UU];   {Di02UL}
 
 Cbl and Di02UG bind yielding Di02UL [Cbl] + [Di02UG] ↔ [Di02UL];   {Cbl} , {Di02UG}
 
 Di02UL dissociates to Cbl and Di02UG [Di02UL] ↔ [Cbl] + [Di02UG];   {Di02UL}
 
 Cbl and Di12UU bind yielding Di12CU [Cbl] + [Di12UU] ↔ [Di12CU];   {Cbl} , {Di12UU}
 
 Di12CU dissociates to Cbl and Di12UU [Di12CU] ↔ [Cbl] + [Di12UU];   {Di12CU}
 
 CG and Di12UU bind yielding Di12LU [CG] + [Di12UU] ↔ [Di12LU];   {CG} , {Di12UU}
 
 Di12LU dissociates to CG and Di12UU [Di12LU] ↔ [CG] + [Di12UU];   {Di12LU}
 
 Grb2 and Di12UU bind yielding Di12UG [Grb2] + [Di12UU] ↔ [Di12UG];   {Grb2} , {Di12UU}
 
 Di12UG dissociates to Grb2 and Di12UU [Di12UG] ↔ [Grb2] + [Di12UU];   {Di12UG}
 
 CG and Di12UU bind yielding Di12UL [CG] + [Di12UU] ↔ [Di12UL];   {CG} , {Di12UU}
 
 Di12UL dissociates to CG and Di12UU [Di12UL] ↔ [CG] + [Di12UU];   {Di12UL}
 
 Grb2 and Di12CU bind yielding Di12LU [Grb2] + [Di12CU] ↔ [Di12LU];   {Grb2} , {Di12CU}
 
 Di12LU dissociates to Grb2 and Di12CU [Di12LU] ↔ [Grb2] + [Di12CU];   {Di12LU}
 
 Grb2 and Di12CU bind yielding Di12CG [Grb2] + [Di12CU] ↔ [Di12CG];   {Grb2} , {Di12CU}
 
 Di12CG dissociates to Grb2 and Di12CU [Di12CG] ↔ [Grb2] + [Di12CU];   {Di12CG}
 
 Grb2 and Di12LU bind yielding Di12LG [Grb2] + [Di12LU] ↔ [Di12LG];   {Grb2} , {Di12LU}
 
 Di12LG dissociates to Grb2 and Di12LU [Di12LG] ↔ [Grb2] + [Di12LU];   {Di12LG}
 
 Di12LU transforms in (singly-bound -> doubly-bound) Di12CC [Di12LU] ↔ [Di12CC];   {Di12LU}
 
 Di12CC tranforms in (doubly-bound -> singly-bound) Di12LU [Di12CC] ↔ [Di12LU];   {Di12CC}
 
 Cbl and Di12UG bind yielding Di12CG [Cbl] + [Di12UG] ↔ [Di12CG];   {Cbl} , {Di12UG}
 
 Di12CG dissociates to Cbl and Di12UG [Di12CG] ↔ [Cbl] + [Di12UG];   {Di12CG}
 
 CG and Di12UG bind yielding Di12LG [CG] + [Di12UG] ↔ [Di12LG];   {CG} , {Di12UG}
 
 Di12LG dissociates to CG and Di12UG [Di12LG] ↔ [CG] + [Di12UG];   {Di12LG}
 
 Cbl and Di12UG bind yielding Di12UL [Cbl] + [Di12UG] ↔ [Di12UL];   {Cbl} , {Di12UG}
 
 Di12UL dissociates to Cbl and Di12UG [Di12UL] ↔ [Cbl] + [Di12UG];   {Di12UL}
 
 Di12UL transforms in (singly-bound -> doubly-bound) Di12CC [Di12UL] ↔ [Di12CC];   {Di12UL}
 
 Di12CC tranforms in (doubly-bound -> singly-bound) Di12UL [Di12CC] ↔ [Di12UL];   {Di12CC}
 
 Di12CG transforms in (Cbl bind Grb2 directly) Di12CC [Di12CG] ↔ [Di12CC];   {Di12CG}
 
 Di12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Di12CG [Di12CC] ↔ [Di12CG];   {Di12CC}
 
 Grb2 and Di12CG bind yielding Di12LG [Grb2] + [Di12CG] ↔ [Di12LG];   {Grb2} , {Di12CG}
 
 Di12LG dissociates to Grb2 and Di12CG [Di12LG] ↔ [Grb2] + [Di12CG];   {Di12LG}
 
 Cbl and Da10UU bind yielding Da10CU [Cbl] + [Da10UU] ↔ [Da10CU];   {Cbl} , {Da10UU}
 
 Da10CU dissociates to Cbl and Da10UU [Da10CU] ↔ [Cbl] + [Da10UU];   {Da10CU}
 
 CG and Da10UU bind yielding Da10LU [CG] + [Da10UU] ↔ [Da10LU];   {CG} , {Da10UU}
 
 Da10LU dissociates to CG and Da10UU [Da10LU] ↔ [CG] + [Da10UU];   {Da10LU}
 
 Grb2 and Da10CU bind yielding Da10LU [Grb2] + [Da10CU] ↔ [Da10LU];   {Grb2} , {Da10CU}
 
 Da10LU dissociates to Grb2 and Da10CU [Da10LU] ↔ [Grb2] + [Da10CU];   {Da10LU}
 
 Grb2 and Da01UU bind yielding Da01UG [Grb2] + [Da01UU] ↔ [Da01UG];   {Grb2} , {Da01UU}
 
 Da01UG dissociates to Grb2 and Da01UU [Da01UG] ↔ [Grb2] + [Da01UU];   {Da01UG}
 
 CG and Da01UU bind yielding Da01UL [CG] + [Da01UU] ↔ [Da01UL];   {CG} , {Da01UU}
 
 Da01UL dissociates to CG and Da01UU [Da01UL] ↔ [CG] + [Da01UU];   {Da01UL}
 
 Cbl and Da01UG bind yielding Da01UL [Cbl] + [Da01UG] ↔ [Da01UL];   {Cbl} , {Da01UG}
 
 Da01UL dissociates to Cbl and Da01UG [Da01UL] ↔ [Cbl] + [Da01UG];   {Da01UL}
 
 Cbl and Da11UU bind yielding Da11CU [Cbl] + [Da11UU] ↔ [Da11CU];   {Cbl} , {Da11UU}
 
 Da11CU dissociates to Cbl and Da11UU [Da11CU] ↔ [Cbl] + [Da11UU];   {Da11CU}
 
 CG and Da11UU bind yielding Da11LU [CG] + [Da11UU] ↔ [Da11LU];   {CG} , {Da11UU}
 
 Da11LU dissociates to CG and Da11UU [Da11LU] ↔ [CG] + [Da11UU];   {Da11LU}
 
 Grb2 and Da11UU bind yielding Da11UG [Grb2] + [Da11UU] ↔ [Da11UG];   {Grb2} , {Da11UU}
 
 Da11UG dissociates to Grb2 and Da11UU [Da11UG] ↔ [Grb2] + [Da11UU];   {Da11UG}
 
 CG and Da11UU bind yielding Da11UL [CG] + [Da11UU] ↔ [Da11UL];   {CG} , {Da11UU}
 
 Da11UL dissociates to CG and Da11UU [Da11UL] ↔ [CG] + [Da11UU];   {Da11UL}
 
 Grb2 and Da11CU bind yielding Da11LU [Grb2] + [Da11CU] ↔ [Da11LU];   {Grb2} , {Da11CU}
 
 Da11LU dissociates to Grb2 and Da11CU [Da11LU] ↔ [Grb2] + [Da11CU];   {Da11LU}
 
 Grb2 and Da11CU bind yielding Da11CG [Grb2] + [Da11CU] ↔ [Da11CG];   {Grb2} , {Da11CU}
 
 Da11CG dissociates to Grb2 and Da11CU [Da11CG] ↔ [Grb2] + [Da11CU];   {Da11CG}
 
 Grb2 and Da11LU bind yielding Da11LG [Grb2] + [Da11LU] ↔ [Da11LG];   {Grb2} , {Da11LU}
 
 Da11LG dissociates to Grb2 and Da11LU [Da11LG] ↔ [Grb2] + [Da11LU];   {Da11LG}
 
 Da11LU transforms in (singly-bound -> doubly-bound) Da11CC [Da11LU] ↔ [Da11CC];   {Da11LU}
 
 Da11CC tranforms in (doubly-bound -> singly-bound) Da11LU [Da11CC] ↔ [Da11LU];   {Da11CC}
 
 Cbl and Da11UG bind yielding Da11CG [Cbl] + [Da11UG] ↔ [Da11CG];   {Cbl} , {Da11UG}
 
 Da11CG dissociates to Cbl and Da11UG [Da11CG] ↔ [Cbl] + [Da11UG];   {Da11CG}
 
 CG and Da11UG bind yielding Da11LG [CG] + [Da11UG] ↔ [Da11LG];   {CG} , {Da11UG}
 
 Da11LG dissociates to CG and Da11UG [Da11LG] ↔ [CG] + [Da11UG];   {Da11LG}
 
 Cbl and Da11UG bind yielding Da11UL [Cbl] + [Da11UG] ↔ [Da11UL];   {Cbl} , {Da11UG}
 
 Da11UL dissociates to Cbl and Da11UG [Da11UL] ↔ [Cbl] + [Da11UG];   {Da11UL}
 
 Da11UL transforms in (singly-bound -> doubly-bound) Da11CC [Da11UL] ↔ [Da11CC];   {Da11UL}
 
 Da11CC tranforms in (doubly-bound -> singly-bound) Da11UL [Da11CC] ↔ [Da11UL];   {Da11CC}
 
 Da11CG transforms in (Cbl bind Grb2 directly) Da11CC [Da11CG] ↔ [Da11CC];   {Da11CG}
 
 Da11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Da11CG [Da11CC] ↔ [Da11CG];   {Da11CC}
 
 Grb2 and Da11CG bind yielding Da11LG [Grb2] + [Da11CG] ↔ [Da11LG];   {Grb2} , {Da11CG}
 
 Da11LG dissociates to Grb2 and Da11CG [Da11LG] ↔ [Grb2] + [Da11CG];   {Da11LG}
 
 Grb2 and Da02UU bind yielding Da02UG [Grb2] + [Da02UU] ↔ [Da02UG];   {Grb2} , {Da02UU}
 
 Da02UG dissociates to Grb2 and Da02UU [Da02UG] ↔ [Grb2] + [Da02UU];   {Da02UG}
 
 CG and Da02UU bind yielding Da02UL [CG] + [Da02UU] ↔ [Da02UL];   {CG} , {Da02UU}
 
 Da02UL dissociates to CG and Da02UU [Da02UL] ↔ [CG] + [Da02UU];   {Da02UL}
 
 Cbl and Da02UG bind yielding Da02UL [Cbl] + [Da02UG] ↔ [Da02UL];   {Cbl} , {Da02UG}
 
 Da02UL dissociates to Cbl and Da02UG [Da02UL] ↔ [Cbl] + [Da02UG];   {Da02UL}
 
 Cbl and Da12UU bind yielding Da12CU [Cbl] + [Da12UU] ↔ [Da12CU];   {Cbl} , {Da12UU}
 
 Da12CU dissociates to Cbl and Da12UU [Da12CU] ↔ [Cbl] + [Da12UU];   {Da12CU}
 
 CG and Da12UU bind yielding Da12LU [CG] + [Da12UU] ↔ [Da12LU];   {CG} , {Da12UU}
 
 Da12LU dissociates to CG and Da12UU [Da12LU] ↔ [CG] + [Da12UU];   {Da12LU}
 
 Grb2 and Da12UU bind yielding Da12UG [Grb2] + [Da12UU] ↔ [Da12UG];   {Grb2} , {Da12UU}
 
 Da12UG dissociates to Grb2 and Da12UU [Da12UG] ↔ [Grb2] + [Da12UU];   {Da12UG}
 
 CG and Da12UU bind yielding Da12UL [CG] + [Da12UU] ↔ [Da12UL];   {CG} , {Da12UU}
 
 Da12UL dissociates to CG and Da12UU [Da12UL] ↔ [CG] + [Da12UU];   {Da12UL}
 
 Grb2 and Da12CU bind yielding Da12LU [Grb2] + [Da12CU] ↔ [Da12LU];   {Grb2} , {Da12CU}
 
 Da12LU dissociates to Grb2 and Da12CU [Da12LU] ↔ [Grb2] + [Da12CU];   {Da12LU}
 
 Grb2 and Da12CU bind yielding Da12CG [Grb2] + [Da12CU] ↔ [Da12CG];   {Grb2} , {Da12CU}
 
 Da12CG dissociates to Grb2 and Da12CU [Da12CG] ↔ [Grb2] + [Da12CU];   {Da12CG}
 
 Grb2 and Da12LU bind yielding Da12LG [Grb2] + [Da12LU] ↔ [Da12LG];   {Grb2} , {Da12LU}
 
 Da12LG dissociates to Grb2 and Da12LU [Da12LG] ↔ [Grb2] + [Da12LU];   {Da12LG}
 
 Da12LU transforms in (singly-bound -> doubly-bound) Da12CC [Da12LU] ↔ [Da12CC];   {Da12LU}
 
 Da12CC tranforms in (doubly-bound -> singly-bound) Da12LU [Da12CC] ↔ [Da12LU];   {Da12CC}
 
 Cbl and Da12UG bind yielding Da12CG [Cbl] + [Da12UG] ↔ [Da12CG];   {Cbl} , {Da12UG}
 
 Da12CG dissociates to Cbl and Da12UG [Da12CG] ↔ [Cbl] + [Da12UG];   {Da12CG}
 
 CG and Da12UG bind yielding Da12LG [CG] + [Da12UG] ↔ [Da12LG];   {CG} , {Da12UG}
 
 Da12LG dissociates to CG and Da12UG [Da12LG] ↔ [CG] + [Da12UG];   {Da12LG}
 
 Cbl and Da12UG bind yielding Da12UL [Cbl] + [Da12UG] ↔ [Da12UL];   {Cbl} , {Da12UG}
 
 Da12UL dissociates to Cbl and Da12UG [Da12UL] ↔ [Cbl] + [Da12UG];   {Da12UL}
 
 Da12UL transforms in (singly-bound -> doubly-bound) Da12CC [Da12UL] ↔ [Da12CC];   {Da12UL}
 
 Da12CC tranforms in (doubly-bound -> singly-bound) Da12UL [Da12CC] ↔ [Da12UL];   {Da12CC}
 
 Da12CG transforms in (Cbl bind Grb2 directly) Da12CC [Da12CG] ↔ [Da12CC];   {Da12CG}
 
 Da12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) Da12CG [Da12CC] ↔ [Da12CG];   {Da12CC}
 
 Grb2 and Da12CG bind yielding Da12LG [Grb2] + [Da12CG] ↔ [Da12LG];   {Grb2} , {Da12CG}
 
 Da12LG dissociates to Grb2 and Da12CG [Da12LG] ↔ [Grb2] + [Da12CG];   {Da12LG}
 
 Cbl and DiL10UU bind yielding DiL10CU [Cbl] + [DiL10UU] ↔ [DiL10CU];   {Cbl} , {DiL10UU}
 
 DiL10CU dissociates to Cbl and DiL10UU [DiL10CU] ↔ [Cbl] + [DiL10UU];   {DiL10CU}
 
 CG and DiL10UU bind yielding DiL10LU [CG] + [DiL10UU] ↔ [DiL10LU];   {CG} , {DiL10UU}
 
 DiL10LU dissociates to CG and DiL10UU [DiL10LU] ↔ [CG] + [DiL10UU];   {DiL10LU}
 
 Grb2 and DiL10CU bind yielding DiL10LU [Grb2] + [DiL10CU] ↔ [DiL10LU];   {Grb2} , {DiL10CU}
 
 DiL10LU dissociates to Grb2 and DiL10CU [DiL10LU] ↔ [Grb2] + [DiL10CU];   {DiL10LU}
 
 Grb2 and DiL01UU bind yielding DiL01UG [Grb2] + [DiL01UU] ↔ [DiL01UG];   {Grb2} , {DiL01UU}
 
 DiL01UG dissociates to Grb2 and DiL01UU [DiL01UG] ↔ [Grb2] + [DiL01UU];   {DiL01UG}
 
 CG and DiL01UU bind yielding DiL01UL [CG] + [DiL01UU] ↔ [DiL01UL];   {CG} , {DiL01UU}
 
 DiL01UL dissociates to CG and DiL01UU [DiL01UL] ↔ [CG] + [DiL01UU];   {DiL01UL}
 
 Cbl and DiL01UG bind yielding DiL01UL [Cbl] + [DiL01UG] ↔ [DiL01UL];   {Cbl} , {DiL01UG}
 
 DiL01UL dissociates to Cbl and DiL01UG [DiL01UL] ↔ [Cbl] + [DiL01UG];   {DiL01UL}
 
 Cbl and DiL11UU bind yielding DiL11CU [Cbl] + [DiL11UU] ↔ [DiL11CU];   {Cbl} , {DiL11UU}
 
 DiL11CU dissociates to Cbl and DiL11UU [DiL11CU] ↔ [Cbl] + [DiL11UU];   {DiL11CU}
 
 CG and DiL11UU bind yielding DiL11LU [CG] + [DiL11UU] ↔ [DiL11LU];   {CG} , {DiL11UU}
 
 DiL11LU dissociates to CG and DiL11UU [DiL11LU] ↔ [CG] + [DiL11UU];   {DiL11LU}
 
 Grb2 and DiL11UU bind yielding DiL11UG [Grb2] + [DiL11UU] ↔ [DiL11UG];   {Grb2} , {DiL11UU}
 
 DiL11UG dissociates to Grb2 and DiL11UU [DiL11UG] ↔ [Grb2] + [DiL11UU];   {DiL11UG}
 
 CG and DiL11UU bind yielding DiL11UL [CG] + [DiL11UU] ↔ [DiL11UL];   {CG} , {DiL11UU}
 
 DiL11UL dissociates to CG and DiL11UU [DiL11UL] ↔ [CG] + [DiL11UU];   {DiL11UL}
 
 Grb2 and DiL11CU bind yielding DiL11LU [Grb2] + [DiL11CU] ↔ [DiL11LU];   {Grb2} , {DiL11CU}
 
 DiL11LU dissociates to Grb2 and DiL11CU [DiL11LU] ↔ [Grb2] + [DiL11CU];   {DiL11LU}
 
 Grb2 and DiL11CU bind yielding DiL11CG [Grb2] + [DiL11CU] ↔ [DiL11CG];   {Grb2} , {DiL11CU}
 
 DiL11CG dissociates to Grb2 and DiL11CU [DiL11CG] ↔ [Grb2] + [DiL11CU];   {DiL11CG}
 
 Grb2 and DiL11LU bind yielding DiL11LG [Grb2] + [DiL11LU] ↔ [DiL11LG];   {Grb2} , {DiL11LU}
 
 DiL11LG dissociates to Grb2 and DiL11LU [DiL11LG] ↔ [Grb2] + [DiL11LU];   {DiL11LG}
 
 DiL11LU transforms in (singly-bound -> doubly-bound) DiL11CC [DiL11LU] ↔ [DiL11CC];   {DiL11LU}
 
 DiL11CC tranforms in (doubly-bound -> singly-bound) DiL11LU [DiL11CC] ↔ [DiL11LU];   {DiL11CC}
 
 Cbl and DiL11UG bind yielding DiL11CG [Cbl] + [DiL11UG] ↔ [DiL11CG];   {Cbl} , {DiL11UG}
 
 DiL11CG dissociates to Cbl and DiL11UG [DiL11CG] ↔ [Cbl] + [DiL11UG];   {DiL11CG}
 
 CG and DiL11UG bind yielding DiL11LG [CG] + [DiL11UG] ↔ [DiL11LG];   {CG} , {DiL11UG}
 
 DiL11LG dissociates to CG and DiL11UG [DiL11LG] ↔ [CG] + [DiL11UG];   {DiL11LG}
 
 Cbl and DiL11UG bind yielding DiL11UL [Cbl] + [DiL11UG] ↔ [DiL11UL];   {Cbl} , {DiL11UG}
 
 DiL11UL dissociates to Cbl and DiL11UG [DiL11UL] ↔ [Cbl] + [DiL11UG];   {DiL11UL}
 
 DiL11UL transforms in (singly-bound -> doubly-bound) DiL11CC [DiL11UL] ↔ [DiL11CC];   {DiL11UL}
 
 DiL11CC tranforms in (doubly-bound -> singly-bound) DiL11UL [DiL11CC] ↔ [DiL11UL];   {DiL11CC}
 
 DiL11CG transforms in (Cbl bind Grb2 directly) DiL11CC [DiL11CG] ↔ [DiL11CC];   {DiL11CG}
 
 DiL11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) DiL11CG [DiL11CC] ↔ [DiL11CG];   {DiL11CC}
 
 Grb2 and DiL11CG bind yielding DiL11LG [Grb2] + [DiL11CG] ↔ [DiL11LG];   {Grb2} , {DiL11CG}
 
 DiL11LG dissociates to Grb2 and DiL11CG [DiL11LG] ↔ [Grb2] + [DiL11CG];   {DiL11LG}
 
 Grb2 and DiL02UU bind yielding DiL02UG [Grb2] + [DiL02UU] ↔ [DiL02UG];   {Grb2} , {DiL02UU}
 
 DiL02UG dissociates to Grb2 and DiL02UU [DiL02UG] ↔ [Grb2] + [DiL02UU];   {DiL02UG}
 
 CG and DiL02UU bind yielding DiL02UL [CG] + [DiL02UU] ↔ [DiL02UL];   {CG} , {DiL02UU}
 
 DiL02UL dissociates to CG and DiL02UU [DiL02UL] ↔ [CG] + [DiL02UU];   {DiL02UL}
 
 Cbl and DiL02UG bind yielding DiL02UL [Cbl] + [DiL02UG] ↔ [DiL02UL];   {Cbl} , {DiL02UG}
 
 DiL02UL dissociates to Cbl and DiL02UG [DiL02UL] ↔ [Cbl] + [DiL02UG];   {DiL02UL}
 
 Cbl and DiL12UU bind yielding DiL12CU [Cbl] + [DiL12UU] ↔ [DiL12CU];   {Cbl} , {DiL12UU}
 
 DiL12CU dissociates to Cbl and DiL12UU [DiL12CU] ↔ [Cbl] + [DiL12UU];   {DiL12CU}
 
 CG and DiL12UU bind yielding DiL12LU [CG] + [DiL12UU] ↔ [DiL12LU];   {CG} , {DiL12UU}
 
 DiL12LU dissociates to CG and DiL12UU [DiL12LU] ↔ [CG] + [DiL12UU];   {DiL12LU}
 
 Grb2 and DiL12UU bind yielding DiL12UG [Grb2] + [DiL12UU] ↔ [DiL12UG];   {Grb2} , {DiL12UU}
 
 DiL12UG dissociates to Grb2 and DiL12UU [DiL12UG] ↔ [Grb2] + [DiL12UU];   {DiL12UG}
 
 CG and DiL12UU bind yielding DiL12UL [CG] + [DiL12UU] ↔ [DiL12UL];   {CG} , {DiL12UU}
 
 DiL12UL dissociates to CG and DiL12UU [DiL12UL] ↔ [CG] + [DiL12UU];   {DiL12UL}
 
 Grb2 and DiL12CU bind yielding DiL12LU [Grb2] + [DiL12CU] ↔ [DiL12LU];   {Grb2} , {DiL12CU}
 
 DiL12LU dissociates to Grb2 and DiL12CU [DiL12LU] ↔ [Grb2] + [DiL12CU];   {DiL12LU}
 
 Grb2 and DiL12CU bind yielding DiL12CG [Grb2] + [DiL12CU] ↔ [DiL12CG];   {Grb2} , {DiL12CU}
 
 DiL12CG dissociates to Grb2 and DiL12CU [DiL12CG] ↔ [Grb2] + [DiL12CU];   {DiL12CG}
 
 Grb2 and DiL12LU bind yielding DiL12LG [Grb2] + [DiL12LU] ↔ [DiL12LG];   {Grb2} , {DiL12LU}
 
 DiL12LG dissociates to Grb2 and DiL12LU [DiL12LG] ↔ [Grb2] + [DiL12LU];   {DiL12LG}
 
 DiL12LU transforms in (singly-bound -> doubly-bound) DiL12CC [DiL12LU] ↔ [DiL12CC];   {DiL12LU}
 
 DiL12CC tranforms in (doubly-bound -> singly-bound) DiL12LU [DiL12CC] ↔ [DiL12LU];   {DiL12CC}
 
 Cbl and DiL12UG bind yielding DiL12CG [Cbl] + [DiL12UG] ↔ [DiL12CG];   {Cbl} , {DiL12UG}
 
 DiL12CG dissociates to Cbl and DiL12UG [DiL12CG] ↔ [Cbl] + [DiL12UG];   {DiL12CG}
 
 CG and DiL12UG bind yielding DiL12LG [CG] + [DiL12UG] ↔ [DiL12LG];   {CG} , {DiL12UG}
 
 DiL12LG dissociates to CG and DiL12UG [DiL12LG] ↔ [CG] + [DiL12UG];   {DiL12LG}
 
 Cbl and DiL12UG bind yielding DiL12UL [Cbl] + [DiL12UG] ↔ [DiL12UL];   {Cbl} , {DiL12UG}
 
 DiL12UL dissociates to Cbl and DiL12UG [DiL12UL] ↔ [Cbl] + [DiL12UG];   {DiL12UL}
 
 DiL12UL transforms in (singly-bound -> doubly-bound) DiL12CC [DiL12UL] ↔ [DiL12CC];   {DiL12UL}
 
 DiL12CC tranforms in (doubly-bound -> singly-bound) DiL12UL [DiL12CC] ↔ [DiL12UL];   {DiL12CC}
 
 DiL12CG transforms in (Cbl bind Grb2 directly) DiL12CC [DiL12CG] ↔ [DiL12CC];   {DiL12CG}
 
 DiL12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) DiL12CG [DiL12CC] ↔ [DiL12CG];   {DiL12CC}
 
 Grb2 and DiL12CG bind yielding DiL12LG [Grb2] + [DiL12CG] ↔ [DiL12LG];   {Grb2} , {DiL12CG}
 
 DiL12LG dissociates to Grb2 and DiL12CG [DiL12LG] ↔ [Grb2] + [DiL12CG];   {DiL12LG}
 
 Cbl and DaL10UU bind yielding DaL10CU [Cbl] + [DaL10UU] ↔ [DaL10CU];   {Cbl} , {DaL10UU}
 
 DaL10CU dissociates to Cbl and DaL10UU [DaL10CU] ↔ [Cbl] + [DaL10UU];   {DaL10CU}
 
 CG and DaL10UU bind yielding DaL10LU [CG] + [DaL10UU] ↔ [DaL10LU];   {CG} , {DaL10UU}
 
 DaL10LU dissociates to CG and DaL10UU [DaL10LU] ↔ [CG] + [DaL10UU];   {DaL10LU}
 
 Grb2 and DaL10CU bind yielding DaL10LU [Grb2] + [DaL10CU] ↔ [DaL10LU];   {Grb2} , {DaL10CU}
 
 DaL10LU dissociates to Grb2 and DaL10CU [DaL10LU] ↔ [Grb2] + [DaL10CU];   {DaL10LU}
 
 Grb2 and DaL01UU bind yielding DaL01UG [Grb2] + [DaL01UU] ↔ [DaL01UG];   {Grb2} , {DaL01UU}
 
 DaL01UG dissociates to Grb2 and DaL01UU [DaL01UG] ↔ [Grb2] + [DaL01UU];   {DaL01UG}
 
 CG and DaL01UU bind yielding DaL01UL [CG] + [DaL01UU] ↔ [DaL01UL];   {CG} , {DaL01UU}
 
 DaL01UL dissociates to CG and DaL01UU [DaL01UL] ↔ [CG] + [DaL01UU];   {DaL01UL}
 
 Cbl and DaL01UG bind yielding DaL01UL [Cbl] + [DaL01UG] ↔ [DaL01UL];   {Cbl} , {DaL01UG}
 
 DaL01UL dissociates to Cbl and DaL01UG [DaL01UL] ↔ [Cbl] + [DaL01UG];   {DaL01UL}
 
 Cbl and DaL11UU bind yielding DaL11CU [Cbl] + [DaL11UU] ↔ [DaL11CU];   {Cbl} , {DaL11UU}
 
 DaL11CU dissociates to Cbl and DaL11UU [DaL11CU] ↔ [Cbl] + [DaL11UU];   {DaL11CU}
 
 CG and DaL11UU bind yielding DaL11LU [CG] + [DaL11UU] ↔ [DaL11LU];   {CG} , {DaL11UU}
 
 DaL11LU dissociates to CG and DaL11UU [DaL11LU] ↔ [CG] + [DaL11UU];   {DaL11LU}
 
 Grb2 and DaL11UU bind yielding DaL11UG [Grb2] + [DaL11UU] ↔ [DaL11UG];   {Grb2} , {DaL11UU}
 
 DaL11UG dissociates to Grb2 and DaL11UU [DaL11UG] ↔ [Grb2] + [DaL11UU];   {DaL11UG}
 
 CG and DaL11UU bind yielding DaL11UL [CG] + [DaL11UU] ↔ [DaL11UL];   {CG} , {DaL11UU}
 
 DaL11UL dissociates to CG and DaL11UU [DaL11UL] ↔ [CG] + [DaL11UU];   {DaL11UL}
 
 Grb2 and DaL11CU bind yielding DaL11LU [Grb2] + [DaL11CU] ↔ [DaL11LU];   {Grb2} , {DaL11CU}
 
 DaL11LU dissociates to Grb2 and DaL11CU [DaL11LU] ↔ [Grb2] + [DaL11CU];   {DaL11LU}
 
 Grb2 and DaL11CU bind yielding DaL11CG [Grb2] + [DaL11CU] ↔ [DaL11CG];   {Grb2} , {DaL11CU}
 
 DaL11CG dissociates to Grb2 and DaL11CU [DaL11CG] ↔ [Grb2] + [DaL11CU];   {DaL11CG}
 
 Grb2 and DaL11LU bind yielding DaL11LG [Grb2] + [DaL11LU] ↔ [DaL11LG];   {Grb2} , {DaL11LU}
 
 DaL11LG dissociates to Grb2 and DaL11LU [DaL11LG] ↔ [Grb2] + [DaL11LU];   {DaL11LG}
 
 DaL11LU transforms in (singly-bound -> doubly-bound) DaL11CC [DaL11LU] ↔ [DaL11CC];   {DaL11LU}
 
 DaL11CC tranforms in (doubly-bound -> singly-bound) DaL11LU [DaL11CC] ↔ [DaL11LU];   {DaL11CC}
 
 Cbl and DaL11UG bind yielding DaL11CG [Cbl] + [DaL11UG] ↔ [DaL11CG];   {Cbl} , {DaL11UG}
 
 DaL11CG dissociates to Cbl and DaL11UG [DaL11CG] ↔ [Cbl] + [DaL11UG];   {DaL11CG}
 
 CG and DaL11UG bind yielding DaL11LG [CG] + [DaL11UG] ↔ [DaL11LG];   {CG} , {DaL11UG}
 
 DaL11LG dissociates to CG and DaL11UG [DaL11LG] ↔ [CG] + [DaL11UG];   {DaL11LG}
 
 Cbl and DaL11UG bind yielding DaL11UL [Cbl] + [DaL11UG] ↔ [DaL11UL];   {Cbl} , {DaL11UG}
 
 DaL11UL dissociates to Cbl and DaL11UG [DaL11UL] ↔ [Cbl] + [DaL11UG];   {DaL11UL}
 
 DaL11UL transforms in (singly-bound -> doubly-bound) DaL11CC [DaL11UL] ↔ [DaL11CC];   {DaL11UL}
 
 DaL11CC tranforms in (doubly-bound -> singly-bound) DaL11UL [DaL11CC] ↔ [DaL11UL];   {DaL11CC}
 
 DaL11CG transforms in (Cbl bind Grb2 directly) DaL11CC [DaL11CG] ↔ [DaL11CC];   {DaL11CG}
 
 DaL11CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) DaL11CG [DaL11CC] ↔ [DaL11CG];   {DaL11CC}
 
 Grb2 and DaL11CG bind yielding DaL11LG [Grb2] + [DaL11CG] ↔ [DaL11LG];   {Grb2} , {DaL11CG}
 
 DaL11LG dissociates to Grb2 and DaL11CG [DaL11LG] ↔ [Grb2] + [DaL11CG];   {DaL11LG}
 
 Grb2 and DaL02UU bind yielding DaL02UG [Grb2] + [DaL02UU] ↔ [DaL02UG];   {Grb2} , {DaL02UU}
 
 DaL02UG dissociates to Grb2 and DaL02UU [DaL02UG] ↔ [Grb2] + [DaL02UU];   {DaL02UG}
 
 CG and DaL02UU bind yielding DaL02UL [CG] + [DaL02UU] ↔ [DaL02UL];   {CG} , {DaL02UU}
 
 DaL02UL dissociates to CG and DaL02UU [DaL02UL] ↔ [CG] + [DaL02UU];   {DaL02UL}
 
 Cbl and DaL02UG bind yielding DaL02UL [Cbl] + [DaL02UG] ↔ [DaL02UL];   {Cbl} , {DaL02UG}
 
 DaL02UL dissociates to Cbl and DaL02UG [DaL02UL] ↔ [Cbl] + [DaL02UG];   {DaL02UL}
 
 Cbl and DaL12UU bind yielding DaL12CU [Cbl] + [DaL12UU] ↔ [DaL12CU];   {Cbl} , {DaL12UU}
 
 DaL12CU dissociates to Cbl and DaL12UU [DaL12CU] ↔ [Cbl] + [DaL12UU];   {DaL12CU}
 
 CG and DaL12UU bind yielding DaL12LU [CG] + [DaL12UU] ↔ [DaL12LU];   {CG} , {DaL12UU}
 
 DaL12LU dissociates to CG and DaL12UU [DaL12LU] ↔ [CG] + [DaL12UU];   {DaL12LU}
 
 Grb2 and DaL12UU bind yielding DaL12UG [Grb2] + [DaL12UU] ↔ [DaL12UG];   {Grb2} , {DaL12UU}
 
 DaL12UG dissociates to Grb2 and DaL12UU [DaL12UG] ↔ [Grb2] + [DaL12UU];   {DaL12UG}
 
 CG and DaL12UU bind yielding DaL12UL [CG] + [DaL12UU] ↔ [DaL12UL];   {CG} , {DaL12UU}
 
 DaL12UL dissociates to CG and DaL12UU [DaL12UL] ↔ [CG] + [DaL12UU];   {DaL12UL}
 
 Grb2 and DaL12CU bind yielding DaL12LU [Grb2] + [DaL12CU] ↔ [DaL12LU];   {Grb2} , {DaL12CU}
 
 DaL12LU dissociates to Grb2 and DaL12CU [DaL12LU] ↔ [Grb2] + [DaL12CU];   {DaL12LU}
 
 Grb2 and DaL12CU bind yielding DaL12CG [Grb2] + [DaL12CU] ↔ [DaL12CG];   {Grb2} , {DaL12CU}
 
 DaL12CG dissociates to Grb2 and DaL12CU [DaL12CG] ↔ [Grb2] + [DaL12CU];   {DaL12CG}
 
 Grb2 and DaL12LU bind yielding DaL12LG [Grb2] + [DaL12LU] ↔ [DaL12LG];   {Grb2} , {DaL12LU}
 
 DaL12LG dissociates to Grb2 and DaL12LU [DaL12LG] ↔ [Grb2] + [DaL12LU];   {DaL12LG}
 
 DaL12LU transforms in (singly-bound -> doubly-bound) DaL12CC [DaL12LU] ↔ [DaL12CC];   {DaL12LU}
 
 DaL12CC tranforms in (doubly-bound -> singly-bound) DaL12LU [DaL12CC] ↔ [DaL12LU];   {DaL12CC}
 
 Cbl and DaL12UG bind yielding DaL12CG [Cbl] + [DaL12UG] ↔ [DaL12CG];   {Cbl} , {DaL12UG}
 
 DaL12CG dissociates to Cbl and DaL12UG [DaL12CG] ↔ [Cbl] + [DaL12UG];   {DaL12CG}
 
 CG and DaL12UG bind yielding DaL12LG [CG] + [DaL12UG] ↔ [DaL12LG];   {CG} , {DaL12UG}
 
 DaL12LG dissociates to CG and DaL12UG [DaL12LG] ↔ [CG] + [DaL12UG];   {DaL12LG}
 
 Cbl and DaL12UG bind yielding DaL12UL [Cbl] + [DaL12UG] ↔ [DaL12UL];   {Cbl} , {DaL12UG}
 
 DaL12UL dissociates to Cbl and DaL12UG [DaL12UL] ↔ [Cbl] + [DaL12UG];   {DaL12UL}
 
 DaL12UL transforms in (singly-bound -> doubly-bound) DaL12CC [DaL12UL] ↔ [DaL12CC];   {DaL12UL}
 
 DaL12CC tranforms in (doubly-bound -> singly-bound) DaL12UL [DaL12CC] ↔ [DaL12UL];   {DaL12CC}
 
 DaL12CG transforms in (Cbl bind Grb2 directly) DaL12CC [DaL12CG] ↔ [DaL12CC];   {DaL12CG}
 
 DaL12CC tranforms in (Cbl-Grb2 loose direct binding, but stay bound to EGFR) DaL12CG [DaL12CC] ↔ [DaL12CG];   {DaL12CC}
 
 Grb2 and DaL12CG bind yielding DaL12LG [Grb2] + [DaL12CG] ↔ [DaL12LG];   {Grb2} , {DaL12CG}
 
 DaL12LG dissociates to Grb2 and DaL12CG [DaL12LG] ↔ [Grb2] + [DaL12CG];   {DaL12LG}
 
 R00UU closes [R00UU] ↔ [Rc00UU];   {R00UU}
 
 R10UU closes [R10UU] ↔ [Rc10UU];   {R10UU}
 
 R10CU closes [R10CU] ↔ [Rc10CU];   {R10CU}
 
 R10LU closes [R10LU] ↔ [Rc10LU];   {R10LU}
 
 R01UU closes [R01UU] ↔ [Rc01UU];   {R01UU}
 
 R01UG closes [R01UG] ↔ [Rc01UG];   {R01UG}
 
 R01UL closes [R01UL] ↔ [Rc01UL];   {R01UL}
 
 R11UU closes [R11UU] ↔ [Rc11UU];   {R11UU}
 
 R11CU closes [R11CU] ↔ [Rc11CU];   {R11CU}
 
 R11LU closes [R11LU] ↔ [Rc11LU];   {R11LU}
 
 R11UG closes [R11UG] ↔ [Rc11UG];   {R11UG}
 
 R11UL closes [R11UL] ↔ [Rc11UL];   {R11UL}
 
 R11CG closes [R11CG] ↔ [Rc11CG];   {R11CG}
 
 R11CC closes [R11CC] ↔ [Rc11CC];   {R11CC}
 
 R11LG closes [R11LG] ↔ [Rc11LG];   {R11LG}
 
 R02UU closes [R02UU] ↔ [Rc02UU];   {R02UU}
 
 R02UG closes [R02UG] ↔ [Rc02UG];   {R02UG}
 
 R02UL closes [R02UL] ↔ [Rc02UL];   {R02UL}
 
 R12UU closes [R12UU] ↔ [Rc12UU];   {R12UU}
 
 R12CU closes [R12CU] ↔ [Rc12CU];   {R12CU}
 
 R12LU closes [R12LU] ↔ [Rc12LU];   {R12LU}
 
 R12UG closes [R12UG] ↔ [Rc12UG];   {R12UG}
 
 R12UL closes [R12UL] ↔ [Rc12UL];   {R12UL}
 
 R12CG closes [R12CG] ↔ [Rc12CG];   {R12CG}
 
 R12CC closes [R12CC] ↔ [Rc12CC];   {R12CC}
 
 R12LG closes [R12LG] ↔ [Rc12LG];   {R12LG}
 
 Rc00UU opens [Rc00UU] ↔ [R00UU];   {Rc00UU}
 
 Rc10UU opens [Rc10UU] ↔ [R10UU];   {Rc10UU}
 
 Rc10CU opens [Rc10CU] ↔ [R10CU];   {Rc10CU}
 
 Rc10LU opens [Rc10LU] ↔ [R10LU];   {Rc10LU}
 
 Rc01UU opens [Rc01UU] ↔ [R01UU];   {Rc01UU}
 
 Rc01UG opens [Rc01UG] ↔ [R01UG];   {Rc01UG}
 
 Rc01UL opens [Rc01UL] ↔ [R01UL];   {Rc01UL}
 
 Rc11UU opens [Rc11UU] ↔ [R11UU];   {Rc11UU}
 
 Rc11CU opens [Rc11CU] ↔ [R11CU];   {Rc11CU}
 
 Rc11LU opens [Rc11LU] ↔ [R11LU];   {Rc11LU}
 
 Rc11UG opens [Rc11UG] ↔ [R11UG];   {Rc11UG}
 
 Rc11UL opens [Rc11UL] ↔ [R11UL];   {Rc11UL}
 
 Rc11CG opens [Rc11CG] ↔ [R11CG];   {Rc11CG}
 
 Rc11CC opens [Rc11CC] ↔ [R11CC];   {Rc11CC}
 
 Rc11LG opens [Rc11LG] ↔ [R11LG];   {Rc11LG}
 
 Rc02UU opens [Rc02UU] ↔ [R02UU];   {Rc02UU}
 
 Rc02UG opens [Rc02UG] ↔ [R02UG];   {Rc02UG}
 
 Rc02UL opens [Rc02UL] ↔ [R02UL];   {Rc02UL}
 
 Rc12UU opens [Rc12UU] ↔ [R12UU];   {Rc12UU}
 
 Rc12CU opens [Rc12CU] ↔ [R12CU];   {Rc12CU}
 
 Rc12LU opens [Rc12LU] ↔ [R12LU];   {Rc12LU}
 
 Rc12UG opens [Rc12UG] ↔ [R12UG];   {Rc12UG}
 
 Rc12UL opens [Rc12UL] ↔ [R12UL];   {Rc12UL}
 
 Rc12CG opens [Rc12CG] ↔ [R12CG];   {Rc12CG}
 
 Rc12CC opens [Rc12CC] ↔ [R12CC];   {Rc12CC}
 
 Rc12LG opens [Rc12LG] ↔ [R12LG];   {Rc12LG}
 
 RL00UU closes [RL00UU] ↔ [RcL00UU];   {RL00UU}
 
 RL10UU closes [RL10UU] ↔ [RcL10UU];   {RL10UU}
 
 RL10CU closes [RL10CU] ↔ [RcL10CU];   {RL10CU}
 
 RL10LU closes [RL10LU] ↔ [RcL10LU];   {RL10LU}
 
 RL01UU closes [RL01UU] ↔ [RcL01UU];   {RL01UU}
 
 RL01UG closes [RL01UG] ↔ [RcL01UG];   {RL01UG}
 
 RL01UL closes [RL01UL] ↔ [RcL01UL];   {RL01UL}
 
 RL11UU closes [RL11UU] ↔ [RcL11UU];   {RL11UU}
 
 RL11CU closes [RL11CU] ↔ [RcL11CU];   {RL11CU}
 
 RL11LU closes [RL11LU] ↔ [RcL11LU];   {RL11LU}
 
 RL11UG closes [RL11UG] ↔ [RcL11UG];   {RL11UG}
 
 RL11UL closes [RL11UL] ↔ [RcL11UL];   {RL11UL}
 
 RL11CG closes [RL11CG] ↔ [RcL11CG];   {RL11CG}
 
 RL11CC closes [RL11CC] ↔ [RcL11CC];   {RL11CC}
 
 RL11LG closes [RL11LG] ↔ [RcL11LG];   {RL11LG}
 
 RL02UU closes [RL02UU] ↔ [RcL02UU];   {RL02UU}
 
 RL02UG closes [RL02UG] ↔ [RcL02UG];   {RL02UG}
 
 RL02UL closes [RL02UL] ↔ [RcL02UL];   {RL02UL}
 
 RL12UU closes [RL12UU] ↔ [RcL12UU];   {RL12UU}
 
 RL12CU closes [RL12CU] ↔ [RcL12CU];   {RL12CU}
 
 RL12LU closes [RL12LU] ↔ [RcL12LU];   {RL12LU}
 
 RL12UG closes [RL12UG] ↔ [RcL12UG];   {RL12UG}
 
 RL12UL closes [RL12UL] ↔ [RcL12UL];   {RL12UL}
 
 RL12CG closes [RL12CG] ↔ [RcL12CG];   {RL12CG}
 
 RL12CC closes [RL12CC] ↔ [RcL12CC];   {RL12CC}
 
 RL12LG closes [RL12LG] ↔ [RcL12LG];   {RL12LG}
 
 RcL00UU opens [RcL00UU] ↔ [RL00UU];   {RcL00UU}
 
 RcL10UU opens [RcL10UU] ↔ [RL10UU];   {RcL10UU}
 
 RcL10CU opens [RcL10CU] ↔ [RL10CU];   {RcL10CU}
 
 RcL10LU opens [RcL10LU] ↔ [RL10LU];   {RcL10LU}
 
 RcL01UU opens [RcL01UU] ↔ [RL01UU];   {RcL01UU}
 
 RcL01UG opens [RcL01UG] ↔ [RL01UG];   {RcL01UG}
 
 RcL01UL opens [RcL01UL] ↔ [RL01UL];   {RcL01UL}
 
 RcL11UU opens [RcL11UU] ↔ [RL11UU];   {RcL11UU}
 
 RcL11CU opens [RcL11CU] ↔ [RL11CU];   {RcL11CU}
 
 RcL11LU opens [RcL11LU] ↔ [RL11LU];   {RcL11LU}
 
 RcL11UG opens [RcL11UG] ↔ [RL11UG];   {RcL11UG}
 
 RcL11UL opens [RcL11UL] ↔ [RL11UL];   {RcL11UL}
 
 RcL11CG opens [RcL11CG] ↔ [RL11CG];   {RcL11CG}
 
 RcL11CC opens [RcL11CC] ↔ [RL11CC];   {RcL11CC}
 
 RcL11LG opens [RcL11LG] ↔ [RL11LG];   {RcL11LG}
 
 RcL02UU opens [RcL02UU] ↔ [RL02UU];   {RcL02UU}
 
 RcL02UG opens [RcL02UG] ↔ [RL02UG];   {RcL02UG}
 
 RcL02UL opens [RcL02UL] ↔ [RL02UL];   {RcL02UL}
 
 RcL12UU opens [RcL12UU] ↔ [RL12UU];   {RcL12UU}
 
 RcL12CU opens [RcL12CU] ↔ [RL12CU];   {RcL12CU}
 
 RcL12LU opens [RcL12LU] ↔ [RL12LU];   {RcL12LU}
 
 RcL12UG opens [RcL12UG] ↔ [RL12UG];   {RcL12UG}
 
 RcL12UL opens [RcL12UL] ↔ [RL12UL];   {RcL12UL}
 
 RcL12CG opens [RcL12CG] ↔ [RL12CG];   {RcL12CG}
 
 RcL12CC opens [RcL12CC] ↔ [RL12CC];   {RcL12CC}
 
 RcL12LG opens [RcL12LG] ↔ [RL12LG];   {RcL12LG}
 
 R00UU binds ligand [R00UU] + [L] ↔ [RL00UU];   {R00UU} , {L}
 
 R10UU binds ligand [R10UU] + [L] ↔ [RL10UU];   {R10UU} , {L}
 
 R10CU binds ligand [R10CU] + [L] ↔ [RL10CU];   {R10CU} , {L}
 
 R10LU binds ligand [R10LU] + [L] ↔ [RL10LU];   {R10LU} , {L}
 
 R01UU binds ligand [R01UU] + [L] ↔ [RL01UU];   {R01UU} , {L}
 
 R01UG binds ligand [R01UG] + [L] ↔ [RL01UG];   {R01UG} , {L}
 
 R01UL binds ligand [R01UL] + [L] ↔ [RL01UL];   {R01UL} , {L}
 
 R11UU binds ligand [R11UU] + [L] ↔ [RL11UU];   {R11UU} , {L}
 
 R11CU binds ligand [R11CU] + [L] ↔ [RL11CU];   {R11CU} , {L}
 
 R11LU binds ligand [R11LU] + [L] ↔ [RL11LU];   {R11LU} , {L}
 
 R11UG binds ligand [R11UG] + [L] ↔ [RL11UG];   {R11UG} , {L}
 
 R11UL binds ligand [R11UL] + [L] ↔ [RL11UL];   {R11UL} , {L}
 
 R11CG binds ligand [R11CG] + [L] ↔ [RL11CG];   {R11CG} , {L}
 
 R11CC binds ligand [R11CC] + [L] ↔ [RL11CC];   {R11CC} , {L}
 
 R11LG binds ligand [R11LG] + [L] ↔ [RL11LG];   {R11LG} , {L}
 
 R02UU binds ligand [R02UU] + [L] ↔ [RL02UU];   {R02UU} , {L}
 
 R02UG binds ligand [R02UG] + [L] ↔ [RL02UG];   {R02UG} , {L}
 
 R02UL binds ligand [R02UL] + [L] ↔ [RL02UL];   {R02UL} , {L}
 
 R12UU binds ligand [R12UU] + [L] ↔ [RL12UU];   {R12UU} , {L}
 
 R12CU binds ligand [R12CU] + [L] ↔ [RL12CU];   {R12CU} , {L}
 
 R12LU binds ligand [R12LU] + [L] ↔ [RL12LU];   {R12LU} , {L}
 
 R12UG binds ligand [R12UG] + [L] ↔ [RL12UG];   {R12UG} , {L}
 
 R12UL binds ligand [R12UL] + [L] ↔ [RL12UL];   {R12UL} , {L}
 
 R12CG binds ligand [R12CG] + [L] ↔ [RL12CG];   {R12CG} , {L}
 
 R12CC binds ligand [R12CC] + [L] ↔ [RL12CC];   {R12CC} , {L}
 
 R12LG binds ligand [R12LG] + [L] ↔ [RL12LG];   {R12LG} , {L}
 
 Rc00UU binds ligand [Rc00UU] + [L] ↔ [RcL00UU];   {Rc00UU} , {L}
 
 Rc10UU binds ligand [Rc10UU] + [L] ↔ [RcL10UU];   {Rc10UU} , {L}
 
 Rc10CU binds ligand [Rc10CU] + [L] ↔ [RcL10CU];   {Rc10CU} , {L}
 
 Rc10LU binds ligand [Rc10LU] + [L] ↔ [RcL10LU];   {Rc10LU} , {L}
 
 Rc01UU binds ligand [Rc01UU] + [L] ↔ [RcL01UU];   {Rc01UU} , {L}
 
 Rc01UG binds ligand [Rc01UG] + [L] ↔ [RcL01UG];   {Rc01UG} , {L}
 
 Rc01UL binds ligand [Rc01UL] + [L] ↔ [RcL01UL];   {Rc01UL} , {L}
 
 Rc11UU binds ligand [Rc11UU] + [L] ↔ [RcL11UU];   {Rc11UU} , {L}
 
 Rc11CU binds ligand [Rc11CU] + [L] ↔ [RcL11CU];   {Rc11CU} , {L}
 
 Rc11LU binds ligand [Rc11LU] + [L] ↔ [RcL11LU];   {Rc11LU} , {L}
 
 Rc11UG binds ligand [Rc11UG] + [L] ↔ [RcL11UG];   {Rc11UG} , {L}
 
 Rc11UL binds ligand [Rc11UL] + [L] ↔ [RcL11UL];   {Rc11UL} , {L}
 
 Rc11CG binds ligand [Rc11CG] + [L] ↔ [RcL11CG];   {Rc11CG} , {L}
 
 Rc11CC binds ligand [Rc11CC] + [L] ↔ [RcL11CC];   {Rc11CC} , {L}
 
 Rc11LG binds ligand [Rc11LG] + [L] ↔ [RcL11LG];   {Rc11LG} , {L}
 
 Rc02UU binds ligand [Rc02UU] + [L] ↔ [RcL02UU];   {Rc02UU} , {L}
 
 Rc02UG binds ligand [Rc02UG] + [L] ↔ [RcL02UG];   {Rc02UG} , {L}
 
 Rc02UL binds ligand [Rc02UL] + [L] ↔ [RcL02UL];   {Rc02UL} , {L}
 
 Rc12UU binds ligand [Rc12UU] + [L] ↔ [RcL12UU];   {Rc12UU} , {L}
 
 Rc12CU binds ligand [Rc12CU] + [L] ↔ [RcL12CU];   {Rc12CU} , {L}
 
 Rc12LU binds ligand [Rc12LU] + [L] ↔ [RcL12LU];   {Rc12LU} , {L}
 
 Rc12UG binds ligand [Rc12UG] + [L] ↔ [RcL12UG];   {Rc12UG} , {L}
 
 Rc12UL binds ligand [Rc12UL] + [L] ↔ [RcL12UL];   {Rc12UL} , {L}
 
 Rc12CG binds ligand [Rc12CG] + [L] ↔ [RcL12CG];   {Rc12CG} , {L}
 
 Rc12CC binds ligand [Rc12CC] + [L] ↔ [RcL12CC];   {Rc12CC} , {L}
 
 Rc12LG binds ligand [Rc12LG] + [L] ↔ [RcL12LG];   {Rc12LG} , {L}
 
 Di00UU partner binds ligand [Di00UU] ↔ [Da00UU];   {L} , {Di00UU} , {L}
 
 Di10UU partner binds ligand [Di10UU] ↔ [Da10UU];   {L} , {Di10UU} , {L}
 
 Di10CU partner binds ligand [Di10CU] ↔ [Da10CU];   {L} , {Di10CU} , {L}
 
 Di10LU partner binds ligand [Di10LU] ↔ [Da10LU];   {L} , {Di10LU} , {L}
 
 Di01UU partner binds ligand [Di01UU] ↔ [Da01UU];   {L} , {Di01UU} , {L}
 
 Di01UG partner binds ligand [Di01UG] ↔ [Da01UG];   {L} , {Di01UG} , {L}
 
 Di01UL partner binds ligand [Di01UL] ↔ [Da01UL];   {L} , {Di01UL} , {L}
 
 Di11UU partner binds ligand [Di11UU] ↔ [Da11UU];   {L} , {Di11UU} , {L}
 
 Di11CU partner binds ligand [Di11CU] ↔ [Da11CU];   {L} , {Di11CU} , {L}
 
 Di11LU partner binds ligand [Di11LU] ↔ [Da11LU];   {L} , {Di11LU} , {L}
 
 Di11UG partner binds ligand [Di11UG] ↔ [Da11UG];   {L} , {Di11UG} , {L}
 
 Di11UL partner binds ligand [Di11UL] ↔ [Da11UL];   {L} , {Di11UL} , {L}
 
 Di11CG partner binds ligand [Di11CG] ↔ [Da11CG];   {L} , {Di11CG} , {L}
 
 Di11CC partner binds ligand [Di11CC] ↔ [Da11CC];   {L} , {Di11CC} , {L}
 
 Di11LG partner binds ligand [Di11LG] ↔ [Da11LG];   {L} , {Di11LG} , {L}
 
 Di02UU partner binds ligand [Di02UU] ↔ [Da02UU];   {L} , {Di02UU} , {L}
 
 Di02UG partner binds ligand [Di02UG] ↔ [Da02UG];   {L} , {Di02UG} , {L}
 
 Di02UL partner binds ligand [Di02UL] ↔ [Da02UL];   {L} , {Di02UL} , {L}
 
 Di12UU partner binds ligand [Di12UU] ↔ [Da12UU];   {L} , {Di12UU} , {L}
 
 Di12CU partner binds ligand [Di12CU] ↔ [Da12CU];   {L} , {Di12CU} , {L}
 
 Di12LU partner binds ligand [Di12LU] ↔ [Da12LU];   {L} , {Di12LU} , {L}
 
 Di12UG partner binds ligand [Di12UG] ↔ [Da12UG];   {L} , {Di12UG} , {L}
 
 Di12UL partner binds ligand [Di12UL] ↔ [Da12UL];   {L} , {Di12UL} , {L}
 
 Di12CG partner binds ligand [Di12CG] ↔ [Da12CG];   {L} , {Di12CG} , {L}
 
 Di12CC partner binds ligand [Di12CC] ↔ [Da12CC];   {L} , {Di12CC} , {L}
 
 Di12LG partner binds ligand [Di12LG] ↔ [Da12LG];   {L} , {Di12LG} , {L}
 
 Di00UU binds ligand [Di00UU] + [L] ↔ [DiL00UU];   {Di00UU} , {L}
 
 Di10UU binds ligand [Di10UU] + [L] ↔ [DiL10UU];   {Di10UU} , {L}
 
 Di10CU binds ligand [Di10CU] + [L] ↔ [DiL10CU];   {Di10CU} , {L}
 
 Di10LU binds ligand [Di10LU] + [L] ↔ [DiL10LU];   {Di10LU} , {L}
 
 Di01UU binds ligand [Di01UU] + [L] ↔ [DiL01UU];   {Di01UU} , {L}
 
 Di01UG binds ligand [Di01UG] + [L] ↔ [DiL01UG];   {Di01UG} , {L}
 
 Di01UL binds ligand [Di01UL] + [L] ↔ [DiL01UL];   {Di01UL} , {L}
 
 Di11UU binds ligand [Di11UU] + [L] ↔ [DiL11UU];   {Di11UU} , {L}
 
 Di11CU binds ligand [Di11CU] + [L] ↔ [DiL11CU];   {Di11CU} , {L}
 
 Di11LU binds ligand [Di11LU] + [L] ↔ [DiL11LU];   {Di11LU} , {L}
 
 Di11UG binds ligand [Di11UG] + [L] ↔ [DiL11UG];   {Di11UG} , {L}
 
 Di11UL binds ligand [Di11UL] + [L] ↔ [DiL11UL];   {Di11UL} , {L}
 
 Di11CG binds ligand [Di11CG] + [L] ↔ [DiL11CG];   {Di11CG} , {L}
 
 Di11CC binds ligand [Di11CC] + [L] ↔ [DiL11CC];   {Di11CC} , {L}
 
 Di11LG binds ligand [Di11LG] + [L] ↔ [DiL11LG];   {Di11LG} , {L}
 
 Di02UU binds ligand [Di02UU] + [L] ↔ [DiL02UU];   {Di02UU} , {L}
 
 Di02UG binds ligand [Di02UG] + [L] ↔ [DiL02UG];   {Di02UG} , {L}
 
 Di02UL binds ligand [Di02UL] + [L] ↔ [DiL02UL];   {Di02UL} , {L}
 
 Di12UU binds ligand [Di12UU] + [L] ↔ [DiL12UU];   {Di12UU} , {L}
 
 Di12CU binds ligand [Di12CU] + [L] ↔ [DiL12CU];   {Di12CU} , {L}
 
 Di12LU binds ligand [Di12LU] + [L] ↔ [DiL12LU];   {Di12LU} , {L}
 
 Di12UG binds ligand [Di12UG] + [L] ↔ [DiL12UG];   {Di12UG} , {L}
 
 Di12UL binds ligand [Di12UL] + [L] ↔ [DiL12UL];   {Di12UL} , {L}
 
 Di12CG binds ligand [Di12CG] + [L] ↔ [DiL12CG];   {Di12CG} , {L}
 
 Di12CC binds ligand [Di12CC] + [L] ↔ [DiL12CC];   {Di12CC} , {L}
 
 Di12LG binds ligand [Di12LG] + [L] ↔ [DiL12LG];   {Di12LG} , {L}
 
 Da00UU binds ligand [Da00UU] + [L] ↔ [DaL00UU];   {Da00UU} , {L}
 
 Da10UU binds ligand [Da10UU] + [L] ↔ [DaL10UU];   {Da10UU} , {L}
 
 Da10CU binds ligand [Da10CU] + [L] ↔ [DaL10CU];   {Da10CU} , {L}
 
 Da10LU binds ligand [Da10LU] + [L] ↔ [DaL10LU];   {Da10LU} , {L}
 
 Da01UU binds ligand [Da01UU] + [L] ↔ [DaL01UU];   {Da01UU} , {L}
 
 Da01UG binds ligand [Da01UG] + [L] ↔ [DaL01UG];   {Da01UG} , {L}
 
 Da01UL binds ligand [Da01UL] + [L] ↔ [DaL01UL];   {Da01UL} , {L}
 
 Da11UU binds ligand [Da11UU] + [L] ↔ [DaL11UU];   {Da11UU} , {L}
 
 Da11CU binds ligand [Da11CU] + [L] ↔ [DaL11CU];   {Da11CU} , {L}
 
 Da11LU binds ligand [Da11LU] + [L] ↔ [DaL11LU];   {Da11LU} , {L}
 
 Da11UG binds ligand [Da11UG] + [L] ↔ [DaL11UG];   {Da11UG} , {L}
 
 Da11UL binds ligand [Da11UL] + [L] ↔ [DaL11UL];   {Da11UL} , {L}
 
 Da11CG binds ligand [Da11CG] + [L] ↔ [DaL11CG];   {Da11CG} , {L}
 
 Da11CC binds ligand [Da11CC] + [L] ↔ [DaL11CC];   {Da11CC} , {L}
 
 Da11LG binds ligand [Da11LG] + [L] ↔ [DaL11LG];   {Da11LG} , {L}
 
 Da02UU binds ligand [Da02UU] + [L] ↔ [DaL02UU];   {Da02UU} , {L}
 
 Da02UG binds ligand [Da02UG] + [L] ↔ [DaL02UG];   {Da02UG} , {L}
 
 Da02UL binds ligand [Da02UL] + [L] ↔ [DaL02UL];   {Da02UL} , {L}
 
 Da12UU binds ligand [Da12UU] + [L] ↔ [DaL12UU];   {Da12UU} , {L}
 
 Da12CU binds ligand [Da12CU] + [L] ↔ [DaL12CU];   {Da12CU} , {L}
 
 Da12LU binds ligand [Da12LU] + [L] ↔ [DaL12LU];   {Da12LU} , {L}
 
 Da12UG binds ligand [Da12UG] + [L] ↔ [DaL12UG];   {Da12UG} , {L}
 
 Da12UL binds ligand [Da12UL] + [L] ↔ [DaL12UL];   {Da12UL} , {L}
 
 Da12CG binds ligand [Da12CG] + [L] ↔ [DaL12CG];   {Da12CG} , {L}
 
 Da12CC binds ligand [Da12CC] + [L] ↔ [DaL12CC];   {Da12CC} , {L}
 
 Da12LG binds ligand [Da12LG] + [L] ↔ [DaL12LG];   {Da12LG} , {L}
 
 DiL00UU partner binds ligand [DiL00UU] ↔ [DaL00UU];   {L} , {DiL00UU} , {L}
 
 DiL10UU partner binds ligand [DiL10UU] ↔ [DaL10UU];   {L} , {DiL10UU} , {L}
 
 DiL10CU partner binds ligand [DiL10CU] ↔ [DaL10CU];   {L} , {DiL10CU} , {L}
 
 DiL10LU partner binds ligand [DiL10LU] ↔ [DaL10LU];   {L} , {DiL10LU} , {L}
 
 DiL01UU partner binds ligand [DiL01UU] ↔ [DaL01UU];   {L} , {DiL01UU} , {L}
 
 DiL01UG partner binds ligand [DiL01UG] ↔ [DaL01UG];   {L} , {DiL01UG} , {L}
 
 DiL01UL partner binds ligand [DiL01UL] ↔ [DaL01UL];   {L} , {DiL01UL} , {L}
 
 DiL11UU partner binds ligand [DiL11UU] ↔ [DaL11UU];   {L} , {DiL11UU} , {L}
 
 DiL11CU partner binds ligand [DiL11CU] ↔ [DaL11CU];   {L} , {DiL11CU} , {L}
 
 DiL11LU partner binds ligand [DiL11LU] ↔ [DaL11LU];   {L} , {DiL11LU} , {L}
 
 DiL11UG partner binds ligand [DiL11UG] ↔ [DaL11UG];   {L} , {DiL11UG} , {L}
 
 DiL11UL partner binds ligand [DiL11UL] ↔ [DaL11UL];   {L} , {DiL11UL} , {L}
 
 DiL11CG partner binds ligand [DiL11CG] ↔ [DaL11CG];   {L} , {DiL11CG} , {L}
 
 DiL11CC partner binds ligand [DiL11CC] ↔ [DaL11CC];   {L} , {DiL11CC} , {L}
 
 DiL11LG partner binds ligand [DiL11LG] ↔ [DaL11LG];   {L} , {DiL11LG} , {L}
 
 DiL02UU partner binds ligand [DiL02UU] ↔ [DaL02UU];   {L} , {DiL02UU} , {L}
 
 DiL02UG partner binds ligand [DiL02UG] ↔ [DaL02UG];   {L} , {DiL02UG} , {L}
 
 DiL02UL partner binds ligand [DiL02UL] ↔ [DaL02UL];   {L} , {DiL02UL} , {L}
 
 DiL12UU partner binds ligand [DiL12UU] ↔ [DaL12UU];   {L} , {DiL12UU} , {L}
 
 DiL12CU partner binds ligand [DiL12CU] ↔ [DaL12CU];   {L} , {DiL12CU} , {L}
 
 DiL12LU partner binds ligand [DiL12LU] ↔ [DaL12LU];   {L} , {DiL12LU} , {L}
 
 DiL12UG partner binds ligand [DiL12UG] ↔ [DaL12UG];   {L} , {DiL12UG} , {L}
 
 DiL12UL partner binds ligand [DiL12UL] ↔ [DaL12UL];   {L} , {DiL12UL} , {L}
 
 DiL12CG partner binds ligand [DiL12CG] ↔ [DaL12CG];   {L} , {DiL12CG} , {L}
 
 DiL12CC partner binds ligand [DiL12CC] ↔ [DaL12CC];   {L} , {DiL12CC} , {L}
 
 DiL12LG partner binds ligand [DiL12LG] ↔ [DaL12LG];   {L} , {DiL12LG} , {L}
 
 RL00UU dissociates ligand [RL00UU] ↔ [R00UU] + [L];   {RL00UU}
 
 RL10UU dissociates ligand [RL10UU] ↔ [R10UU] + [L];   {RL10UU}
 
 RL10CU dissociates ligand [RL10CU] ↔ [R10CU] + [L];   {RL10CU}
 
 RL10LU dissociates ligand [RL10LU] ↔ [R10LU] + [L];   {RL10LU}
 
 RL01UU dissociates ligand [RL01UU] ↔ [R01UU] + [L];   {RL01UU}
 
 RL01UG dissociates ligand [RL01UG] ↔ [R01UG] + [L];   {RL01UG}
 
 RL01UL dissociates ligand [RL01UL] ↔ [R01UL] + [L];   {RL01UL}
 
 RL11UU dissociates ligand [RL11UU] ↔ [R11UU] + [L];   {RL11UU}
 
 RL11CU dissociates ligand [RL11CU] ↔ [R11CU] + [L];   {RL11CU}
 
 RL11LU dissociates ligand [RL11LU] ↔ [R11LU] + [L];   {RL11LU}
 
 RL11UG dissociates ligand [RL11UG] ↔ [R11UG] + [L];   {RL11UG}
 
 RL11UL dissociates ligand [RL11UL] ↔ [R11UL] + [L];   {RL11UL}
 
 RL11CG dissociates ligand [RL11CG] ↔ [R11CG] + [L];   {RL11CG}
 
 RL11CC dissociates ligand [RL11CC] ↔ [R11CC] + [L];   {RL11CC}
 
 RL11LG dissociates ligand [RL11LG] ↔ [R11LG] + [L];   {RL11LG}
 
 RL02UU dissociates ligand [RL02UU] ↔ [R02UU] + [L];   {RL02UU}
 
 RL02UG dissociates ligand [RL02UG] ↔ [R02UG] + [L];   {RL02UG}
 
 RL02UL dissociates ligand [RL02UL] ↔ [R02UL] + [L];   {RL02UL}
 
 RL12UU dissociates ligand [RL12UU] ↔ [R12UU] + [L];   {RL12UU}
 
 RL12CU dissociates ligand [RL12CU] ↔ [R12CU] + [L];   {RL12CU}
 
 RL12LU dissociates ligand [RL12LU] ↔ [R12LU] + [L];   {RL12LU}
 
 RL12UG dissociates ligand [RL12UG] ↔ [R12UG] + [L];   {RL12UG}
 
 RL12UL dissociates ligand [RL12UL] ↔ [R12UL] + [L];   {RL12UL}
 
 RL12CG dissociates ligand [RL12CG] ↔ [R12CG] + [L];   {RL12CG}
 
 RL12CC dissociates ligand [RL12CC] ↔ [R12CC] + [L];   {RL12CC}
 
 RL12LG dissociates ligand [RL12LG] ↔ [R12LG] + [L];   {RL12LG}
 
 RcL00UU dissociates ligand [RcL00UU] ↔ [Rc00UU] + [L];   {RcL00UU}
 
 RcL10UU dissociates ligand [RcL10UU] ↔ [Rc10UU] + [L];   {RcL10UU}
 
 RcL10CU dissociates ligand [RcL10CU] ↔ [Rc10CU] + [L];   {RcL10CU}
 
 RcL10LU dissociates ligand [RcL10LU] ↔ [Rc10LU] + [L];   {RcL10LU}
 
 RcL01UU dissociates ligand [RcL01UU] ↔ [Rc01UU] + [L];   {RcL01UU}
 
 RcL01UG dissociates ligand [RcL01UG] ↔ [Rc01UG] + [L];   {RcL01UG}
 
 RcL01UL dissociates ligand [RcL01UL] ↔ [Rc01UL] + [L];   {RcL01UL}
 
 RcL11UU dissociates ligand [RcL11UU] ↔ [Rc11UU] + [L];   {RcL11UU}
 
 RcL11CU dissociates ligand [RcL11CU] ↔ [Rc11CU] + [L];   {RcL11CU}
 
 RcL11LU dissociates ligand [RcL11LU] ↔ [Rc11LU] + [L];   {RcL11LU}
 
 RcL11UG dissociates ligand [RcL11UG] ↔ [Rc11UG] + [L];   {RcL11UG}
 
 RcL11UL dissociates ligand [RcL11UL] ↔ [Rc11UL] + [L];   {RcL11UL}
 
 RcL11CG dissociates ligand [RcL11CG] ↔ [Rc11CG] + [L];   {RcL11CG}
 
 RcL11CC dissociates ligand [RcL11CC] ↔ [Rc11CC] + [L];   {RcL11CC}
 
 RcL11LG dissociates ligand [RcL11LG] ↔ [Rc11LG] + [L];   {RcL11LG}
 
 RcL02UU dissociates ligand [RcL02UU] ↔ [Rc02UU] + [L];   {RcL02UU}
 
 RcL02UG dissociates ligand [RcL02UG] ↔ [Rc02UG] + [L];   {RcL02UG}
 
 RcL02UL dissociates ligand [RcL02UL] ↔ [Rc02UL] + [L];   {RcL02UL}
 
 RcL12UU dissociates ligand [RcL12UU] ↔ [Rc12UU] + [L];   {RcL12UU}
 
 RcL12CU dissociates ligand [RcL12CU] ↔ [Rc12CU] + [L];   {RcL12CU}
 
 RcL12LU dissociates ligand [RcL12LU] ↔ [Rc12LU] + [L];   {RcL12LU}
 
 RcL12UG dissociates ligand [RcL12UG] ↔ [Rc12UG] + [L];   {RcL12UG}
 
 RcL12UL dissociates ligand [RcL12UL] ↔ [Rc12UL] + [L];   {RcL12UL}
 
 RcL12CG dissociates ligand [RcL12CG] ↔ [Rc12CG] + [L];   {RcL12CG}
 
 RcL12CC dissociates ligand [RcL12CC] ↔ [Rc12CC] + [L];   {RcL12CC}
 
 RcL12LG dissociates ligand [RcL12LG] ↔ [Rc12LG] + [L];   {RcL12LG}
 
 DaL00UU partner dissociates its ligand [DaL00UU] ↔ [DiL00UU];   {DaL00UU}
 
 DaL10UU partner dissociates its ligand [DaL10UU] ↔ [DiL10UU];   {DaL10UU}
 
 DaL10CU partner dissociates its ligand [DaL10CU] ↔ [DiL10CU];   {DaL10CU}
 
 DaL10LU partner dissociates its ligand [DaL10LU] ↔ [DiL10LU];   {DaL10LU}
 
 DaL01UU partner dissociates its ligand [DaL01UU] ↔ [DiL01UU];   {DaL01UU}
 
 DaL01UG partner dissociates its ligand [DaL01UG] ↔ [DiL01UG];   {DaL01UG}
 
 DaL01UL partner dissociates its ligand [DaL01UL] ↔ [DiL01UL];   {DaL01UL}
 
 DaL11UU partner dissociates its ligand [DaL11UU] ↔ [DiL11UU];   {DaL11UU}
 
 DaL11CU partner dissociates its ligand [DaL11CU] ↔ [DiL11CU];   {DaL11CU}
 
 DaL11LU partner dissociates its ligand [DaL11LU] ↔ [DiL11LU];   {DaL11LU}
 
 DaL11UG partner dissociates its ligand [DaL11UG] ↔ [DiL11UG];   {DaL11UG}
 
 DaL11UL partner dissociates its ligand [DaL11UL] ↔ [DiL11UL];   {DaL11UL}
 
 DaL11CG partner dissociates its ligand [DaL11CG] ↔ [DiL11CG];   {DaL11CG}
 
 DaL11CC partner dissociates its ligand [DaL11CC] ↔ [DiL11CC];   {DaL11CC}
 
 DaL11LG partner dissociates its ligand [DaL11LG] ↔ [DiL11LG];   {DaL11LG}
 
 DaL02UU partner dissociates its ligand [DaL02UU] ↔ [DiL02UU];   {DaL02UU}
 
 DaL02UG partner dissociates its ligand [DaL02UG] ↔ [DiL02UG];   {DaL02UG}
 
 DaL02UL partner dissociates its ligand [DaL02UL] ↔ [DiL02UL];   {DaL02UL}
 
 DaL12UU partner dissociates its ligand [DaL12UU] ↔ [DiL12UU];   {DaL12UU}
 
 DaL12CU partner dissociates its ligand [DaL12CU] ↔ [DiL12CU];   {DaL12CU}
 
 DaL12LU partner dissociates its ligand [DaL12LU] ↔ [DiL12LU];   {DaL12LU}
 
 DaL12UG partner dissociates its ligand [DaL12UG] ↔ [DiL12UG];   {DaL12UG}
 
 DaL12UL partner dissociates its ligand [DaL12UL] ↔ [DiL12UL];   {DaL12UL}
 
 DaL12CG partner dissociates its ligand [DaL12CG] ↔ [DiL12CG];   {DaL12CG}
 
 DaL12CC partner dissociates its ligand [DaL12CC] ↔ [DiL12CC];   {DaL12CC}
 
 DaL12LG partner dissociates its ligand [DaL12LG] ↔ [DiL12LG];   {DaL12LG}
 
 DaL00UU dissociates its ligand [DaL00UU] ↔ [Da00UU] + [L];   {DaL00UU}
 
 DaL10UU dissociates its ligand [DaL10UU] ↔ [Da10UU] + [L];   {DaL10UU}
 
 DaL10CU dissociates its ligand [DaL10CU] ↔ [Da10CU] + [L];   {DaL10CU}
 
 DaL10LU dissociates its ligand [DaL10LU] ↔ [Da10LU] + [L];   {DaL10LU}
 
 DaL01UU dissociates its ligand [DaL01UU] ↔ [Da01UU] + [L];   {DaL01UU}
 
 DaL01UG dissociates its ligand [DaL01UG] ↔ [Da01UG] + [L];   {DaL01UG}
 
 DaL01UL dissociates its ligand [DaL01UL] ↔ [Da01UL] + [L];   {DaL01UL}
 
 DaL11UU dissociates its ligand [DaL11UU] ↔ [Da11UU] + [L];   {DaL11UU}
 
 DaL11CU dissociates its ligand [DaL11CU] ↔ [Da11CU] + [L];   {DaL11CU}
 
 DaL11LU dissociates its ligand [DaL11LU] ↔ [Da11LU] + [L];   {DaL11LU}
 
 DaL11UG dissociates its ligand [DaL11UG] ↔ [Da11UG] + [L];   {DaL11UG}
 
 DaL11UL dissociates its ligand [DaL11UL] ↔ [Da11UL] + [L];   {DaL11UL}
 
 DaL11CG dissociates its ligand [DaL11CG] ↔ [Da11CG] + [L];   {DaL11CG}
 
 DaL11CC dissociates its ligand [DaL11CC] ↔ [Da11CC] + [L];   {DaL11CC}
 
 DaL11LG dissociates its ligand [DaL11LG] ↔ [Da11LG] + [L];   {DaL11LG}
 
 DaL02UU dissociates its ligand [DaL02UU] ↔ [Da02UU] + [L];   {DaL02UU}
 
 DaL02UG dissociates its ligand [DaL02UG] ↔ [Da02UG] + [L];   {DaL02UG}
 
 DaL02UL dissociates its ligand [DaL02UL] ↔ [Da02UL] + [L];   {DaL02UL}
 
 DaL12UU dissociates its ligand [DaL12UU] ↔ [Da12UU] + [L];   {DaL12UU}
 
 DaL12CU dissociates its ligand [DaL12CU] ↔ [Da12CU] + [L];   {DaL12CU}
 
 DaL12LU dissociates its ligand [DaL12LU] ↔ [Da12LU] + [L];   {DaL12LU}
 
 DaL12UG dissociates its ligand [DaL12UG] ↔ [Da12UG] + [L];   {DaL12UG}
 
 DaL12UL dissociates its ligand [DaL12UL] ↔ [Da12UL] + [L];   {DaL12UL}
 
 DaL12CG dissociates its ligand [DaL12CG] ↔ [Da12CG] + [L];   {DaL12CG}
 
 DaL12CC dissociates its ligand [DaL12CC] ↔ [Da12CC] + [L];   {DaL12CC}
 
 DaL12LG dissociates its ligand [DaL12LG] ↔ [Da12LG] + [L];   {DaL12LG}
 
 Da00UU partner dissociates its ligand [Da00UU] ↔ [Di00UU];   {Da00UU}
 
 Da10UU partner dissociates its ligand [Da10UU] ↔ [Di10UU];   {Da10UU}
 
 Da10CU partner dissociates its ligand [Da10CU] ↔ [Di10CU];   {Da10CU}
 
 Da10LU partner dissociates its ligand [Da10LU] ↔ [Di10LU];   {Da10LU}
 
 Da01UU partner dissociates its ligand [Da01UU] ↔ [Di01UU];   {Da01UU}
 
 Da01UG partner dissociates its ligand [Da01UG] ↔ [Di01UG];   {Da01UG}
 
 Da01UL partner dissociates its ligand [Da01UL] ↔ [Di01UL];   {Da01UL}
 
 Da11UU partner dissociates its ligand [Da11UU] ↔ [Di11UU];   {Da11UU}
 
 Da11CU partner dissociates its ligand [Da11CU] ↔ [Di11CU];   {Da11CU}
 
 Da11LU partner dissociates its ligand [Da11LU] ↔ [Di11LU];   {Da11LU}
 
 Da11UG partner dissociates its ligand [Da11UG] ↔ [Di11UG];   {Da11UG}
 
 Da11UL partner dissociates its ligand [Da11UL] ↔ [Di11UL];   {Da11UL}
 
 Da11CG partner dissociates its ligand [Da11CG] ↔ [Di11CG];   {Da11CG}
 
 Da11CC partner dissociates its ligand [Da11CC] ↔ [Di11CC];   {Da11CC}
 
 Da11LG partner dissociates its ligand [Da11LG] ↔ [Di11LG];   {Da11LG}
 
 Da02UU partner dissociates its ligand [Da02UU] ↔ [Di02UU];   {Da02UU}
 
 Da02UG partner dissociates its ligand [Da02UG] ↔ [Di02UG];   {Da02UG}
 
 Da02UL partner dissociates its ligand [Da02UL] ↔ [Di02UL];   {Da02UL}
 
 Da12UU partner dissociates its ligand [Da12UU] ↔ [Di12UU];   {Da12UU}
 
 Da12CU partner dissociates its ligand [Da12CU] ↔ [Di12CU];   {Da12CU}
 
 Da12LU partner dissociates its ligand [Da12LU] ↔ [Di12LU];   {Da12LU}
 
 Da12UG partner dissociates its ligand [Da12UG] ↔ [Di12UG];   {Da12UG}
 
 Da12UL partner dissociates its ligand [Da12UL] ↔ [Di12UL];   {Da12UL}
 
 Da12CG partner dissociates its ligand [Da12CG] ↔ [Di12CG];   {Da12CG}
 
 Da12CC partner dissociates its ligand [Da12CC] ↔ [Di12CC];   {Da12CC}
 
 Da12LG partner dissociates its ligand [Da12LG] ↔ [Di12LG];   {Da12LG}
 
 DiL00UU dissociates its ligand [DiL00UU] ↔ [Di00UU] + [L];   {DiL00UU}
 
 DiL10UU dissociates its ligand [DiL10UU] ↔ [Di10UU] + [L];   {DiL10UU}
 
 DiL10CU dissociates its ligand [DiL10CU] ↔ [Di10CU] + [L];   {DiL10CU}
 
 DiL10LU dissociates its ligand [DiL10LU] ↔ [Di10LU] + [L];   {DiL10LU}
 
 DiL01UU dissociates its ligand [DiL01UU] ↔ [Di01UU] + [L];   {DiL01UU}
 
 DiL01UG dissociates its ligand [DiL01UG] ↔ [Di01UG] + [L];   {DiL01UG}
 
 DiL01UL dissociates its ligand [DiL01UL] ↔ [Di01UL] + [L];   {DiL01UL}
 
 DiL11UU dissociates its ligand [DiL11UU] ↔ [Di11UU] + [L];   {DiL11UU}
 
 DiL11CU dissociates its ligand [DiL11CU] ↔ [Di11CU] + [L];   {DiL11CU}
 
 DiL11LU dissociates its ligand [DiL11LU] ↔ [Di11LU] + [L];   {DiL11LU}
 
 DiL11UG dissociates its ligand [DiL11UG] ↔ [Di11UG] + [L];   {DiL11UG}
 
 DiL11UL dissociates its ligand [DiL11UL] ↔ [Di11UL] + [L];   {DiL11UL}
 
 DiL11CG dissociates its ligand [DiL11CG] ↔ [Di11CG] + [L];   {DiL11CG}
 
 DiL11CC dissociates its ligand [DiL11CC] ↔ [Di11CC] + [L];   {DiL11CC}
 
 DiL11LG dissociates its ligand [DiL11LG] ↔ [Di11LG] + [L];   {DiL11LG}
 
 DiL02UU dissociates its ligand [DiL02UU] ↔ [Di02UU] + [L];   {DiL02UU}
 
 DiL02UG dissociates its ligand [DiL02UG] ↔ [Di02UG] + [L];   {DiL02UG}
 
 DiL02UL dissociates its ligand [DiL02UL] ↔ [Di02UL] + [L];   {DiL02UL}
 
 DiL12UU dissociates its ligand [DiL12UU] ↔ [Di12UU] + [L];   {DiL12UU}
 
 DiL12CU dissociates its ligand [DiL12CU] ↔ [Di12CU] + [L];   {DiL12CU}
 
 DiL12LU dissociates its ligand [DiL12LU] ↔ [Di12LU] + [L];   {DiL12LU}
 
 DiL12UG dissociates its ligand [DiL12UG] ↔ [Di12UG] + [L];   {DiL12UG}
 
 DiL12UL dissociates its ligand [DiL12UL] ↔ [Di12UL] + [L];   {DiL12UL}
 
 DiL12CG dissociates its ligand [DiL12CG] ↔ [Di12CG] + [L];   {DiL12CG}
 
 DiL12CC dissociates its ligand [DiL12CC] ↔ [Di12CC] + [L];   {DiL12CC}
 
 DiL12LG dissociates its ligand [DiL12LG] ↔ [Di12LG] + [L];   {DiL12LG}
 
 R00UU dimerizes to Di00UU [R00UU] ↔ [Di00UU];   {SumM} , {R00UU} , {SumM}
 
 R10UU dimerizes to Di10UU [R10UU] ↔ [Di10UU];   {SumM} , {R10UU} , {SumM}
 
 R10CU dimerizes to Di10CU [R10CU] ↔ [Di10CU];   {SumM} , {R10CU} , {SumM}
 
 R10LU dimerizes to Di10LU [R10LU] ↔ [Di10LU];   {SumM} , {R10LU} , {SumM}
 
 R01UU dimerizes to Di01UU [R01UU] ↔ [Di01UU];   {SumM} , {R01UU} , {SumM}
 
 R01UG dimerizes to Di01UG [R01UG] ↔ [Di01UG];   {SumM} , {R01UG} , {SumM}
 
 R01UL dimerizes to Di01UL [R01UL] ↔ [Di01UL];   {SumM} , {R01UL} , {SumM}
 
 R11UU dimerizes to Di11UU [R11UU] ↔ [Di11UU];   {SumM} , {R11UU} , {SumM}
 
 R11CU dimerizes to Di11CU [R11CU] ↔ [Di11CU];   {SumM} , {R11CU} , {SumM}
 
 R11LU dimerizes to Di11LU [R11LU] ↔ [Di11LU];   {SumM} , {R11LU} , {SumM}
 
 R11UG dimerizes to Di11UG [R11UG] ↔ [Di11UG];   {SumM} , {R11UG} , {SumM}
 
 R11UL dimerizes to Di11UL [R11UL] ↔ [Di11UL];   {SumM} , {R11UL} , {SumM}
 
 R11CG dimerizes to Di11CG [R11CG] ↔ [Di11CG];   {SumM} , {R11CG} , {SumM}
 
 R11CC dimerizes to Di11CC [R11CC] ↔ [Di11CC];   {SumM} , {R11CC} , {SumM}
 
 R11LG dimerizes to Di11LG [R11LG] ↔ [Di11LG];   {SumM} , {R11LG} , {SumM}
 
 R02UU dimerizes to Di02UU [R02UU] ↔ [Di02UU];   {SumM} , {R02UU} , {SumM}
 
 R02UG dimerizes to Di02UG [R02UG] ↔ [Di02UG];   {SumM} , {R02UG} , {SumM}
 
 R02UL dimerizes to Di02UL [R02UL] ↔ [Di02UL];   {SumM} , {R02UL} , {SumM}
 
 R12UU dimerizes to Di12UU [R12UU] ↔ [Di12UU];   {SumM} , {R12UU} , {SumM}
 
 R12CU dimerizes to Di12CU [R12CU] ↔ [Di12CU];   {SumM} , {R12CU} , {SumM}
 
 R12LU dimerizes to Di12LU [R12LU] ↔ [Di12LU];   {SumM} , {R12LU} , {SumM}
 
 R12UG dimerizes to Di12UG [R12UG] ↔ [Di12UG];   {SumM} , {R12UG} , {SumM}
 
 R12UL dimerizes to Di12UL [R12UL] ↔ [Di12UL];   {SumM} , {R12UL} , {SumM}
 
 R12CG dimerizes to Di12CG [R12CG] ↔ [Di12CG];   {SumM} , {R12CG} , {SumM}
 
 R12CC dimerizes to Di12CC [R12CC] ↔ [Di12CC];   {SumM} , {R12CC} , {SumM}
 
 R12LG dimerizes to Di12LG [R12LG] ↔ [Di12LG];   {SumM} , {R12LG} , {SumM}
 
 R00UU dimerizes to Da00UU [R00UU] ↔ [Da00UU];   {SumML} , {R00UU} , {SumML}
 
 R10UU dimerizes to Da10UU [R10UU] ↔ [Da10UU];   {SumML} , {R10UU} , {SumML}
 
 R10CU dimerizes to Da10CU [R10CU] ↔ [Da10CU];   {SumML} , {R10CU} , {SumML}
 
 R10LU dimerizes to Da10LU [R10LU] ↔ [Da10LU];   {SumML} , {R10LU} , {SumML}
 
 R01UU dimerizes to Da01UU [R01UU] ↔ [Da01UU];   {SumML} , {R01UU} , {SumML}
 
 R01UG dimerizes to Da01UG [R01UG] ↔ [Da01UG];   {SumML} , {R01UG} , {SumML}
 
 R01UL dimerizes to Da01UL [R01UL] ↔ [Da01UL];   {SumML} , {R01UL} , {SumML}
 
 R11UU dimerizes to Da11UU [R11UU] ↔ [Da11UU];   {SumML} , {R11UU} , {SumML}
 
 R11CU dimerizes to Da11CU [R11CU] ↔ [Da11CU];   {SumML} , {R11CU} , {SumML}
 
 R11LU dimerizes to Da11LU [R11LU] ↔ [Da11LU];   {SumML} , {R11LU} , {SumML}
 
 R11UG dimerizes to Da11UG [R11UG] ↔ [Da11UG];   {SumML} , {R11UG} , {SumML}
 
 R11UL dimerizes to Da11UL [R11UL] ↔ [Da11UL];   {SumML} , {R11UL} , {SumML}
 
 R11CG dimerizes to Da11CG [R11CG] ↔ [Da11CG];   {SumML} , {R11CG} , {SumML}
 
 R11CC dimerizes to Da11CC [R11CC] ↔ [Da11CC];   {SumML} , {R11CC} , {SumML}
 
 R11LG dimerizes to Da11LG [R11LG] ↔ [Da11LG];   {SumML} , {R11LG} , {SumML}
 
 R02UU dimerizes to Da02UU [R02UU] ↔ [Da02UU];   {SumML} , {R02UU} , {SumML}
 
 R02UG dimerizes to Da02UG [R02UG] ↔ [Da02UG];   {SumML} , {R02UG} , {SumML}
 
 R02UL dimerizes to Da02UL [R02UL] ↔ [Da02UL];   {SumML} , {R02UL} , {SumML}
 
 R12UU dimerizes to Da12UU [R12UU] ↔ [Da12UU];   {SumML} , {R12UU} , {SumML}
 
 R12CU dimerizes to Da12CU [R12CU] ↔ [Da12CU];   {SumML} , {R12CU} , {SumML}
 
 R12LU dimerizes to Da12LU [R12LU] ↔ [Da12LU];   {SumML} , {R12LU} , {SumML}
 
 R12UG dimerizes to Da12UG [R12UG] ↔ [Da12UG];   {SumML} , {R12UG} , {SumML}
 
 R12UL dimerizes to Da12UL [R12UL] ↔ [Da12UL];   {SumML} , {R12UL} , {SumML}
 
 R12CG dimerizes to Da12CG [R12CG] ↔ [Da12CG];   {SumML} , {R12CG} , {SumML}
 
 R12CC dimerizes to Da12CC [R12CC] ↔ [Da12CC];   {SumML} , {R12CC} , {SumML}
 
 R12LG dimerizes to Da12LG [R12LG] ↔ [Da12LG];   {SumML} , {R12LG} , {SumML}
 
 RL00UU dimerizes to DiL00UU [RL00UU] ↔ [DiL00UU];   {SumM} , {RL00UU} , {SumM}
 
 RL10UU dimerizes to DiL10UU [RL10UU] ↔ [DiL10UU];   {SumM} , {RL10UU} , {SumM}
 
 RL10CU dimerizes to DiL10CU [RL10CU] ↔ [DiL10CU];   {SumM} , {RL10CU} , {SumM}
 
 RL10LU dimerizes to DiL10LU [RL10LU] ↔ [DiL10LU];   {SumM} , {RL10LU} , {SumM}
 
 RL01UU dimerizes to DiL01UU [RL01UU] ↔ [DiL01UU];   {SumM} , {RL01UU} , {SumM}
 
 RL01UG dimerizes to DiL01UG [RL01UG] ↔ [DiL01UG];   {SumM} , {RL01UG} , {SumM}
 
 RL01UL dimerizes to DiL01UL [RL01UL] ↔ [DiL01UL];   {SumM} , {RL01UL} , {SumM}
 
 RL11UU dimerizes to DiL11UU [RL11UU] ↔ [DiL11UU];   {SumM} , {RL11UU} , {SumM}
 
 RL11CU dimerizes to DiL11CU [RL11CU] ↔ [DiL11CU];   {SumM} , {RL11CU} , {SumM}
 
 RL11LU dimerizes to DiL11LU [RL11LU] ↔ [DiL11LU];   {SumM} , {RL11LU} , {SumM}
 
 RL11UG dimerizes to DiL11UG [RL11UG] ↔ [DiL11UG];   {SumM} , {RL11UG} , {SumM}
 
 RL11UL dimerizes to DiL11UL [RL11UL] ↔ [DiL11UL];   {SumM} , {RL11UL} , {SumM}
 
 RL11CG dimerizes to DiL11CG [RL11CG] ↔ [DiL11CG];   {SumM} , {RL11CG} , {SumM}
 
 RL11CC dimerizes to DiL11CC [RL11CC] ↔ [DiL11CC];   {SumM} , {RL11CC} , {SumM}
 
 RL11LG dimerizes to DiL11LG [RL11LG] ↔ [DiL11LG];   {SumM} , {RL11LG} , {SumM}
 
 RL02UU dimerizes to DiL02UU [RL02UU] ↔ [DiL02UU];   {SumM} , {RL02UU} , {SumM}
 
 RL02UG dimerizes to DiL02UG [RL02UG] ↔ [DiL02UG];   {SumM} , {RL02UG} , {SumM}
 
 RL02UL dimerizes to DiL02UL [RL02UL] ↔ [DiL02UL];   {SumM} , {RL02UL} , {SumM}
 
 RL12UU dimerizes to DiL12UU [RL12UU] ↔ [DiL12UU];   {SumM} , {RL12UU} , {SumM}
 
 RL12CU dimerizes to DiL12CU [RL12CU] ↔ [DiL12CU];   {SumM} , {RL12CU} , {SumM}
 
 RL12LU dimerizes to DiL12LU [RL12LU] ↔ [DiL12LU];   {SumM} , {RL12LU} , {SumM}
 
 RL12UG dimerizes to DiL12UG [RL12UG] ↔ [DiL12UG];   {SumM} , {RL12UG} , {SumM}
 
 RL12UL dimerizes to DiL12UL [RL12UL] ↔ [DiL12UL];   {SumM} , {RL12UL} , {SumM}
 
 RL12CG dimerizes to DiL12CG [RL12CG] ↔ [DiL12CG];   {SumM} , {RL12CG} , {SumM}
 
 RL12CC dimerizes to DiL12CC [RL12CC] ↔ [DiL12CC];   {SumM} , {RL12CC} , {SumM}
 
 RL12LG dimerizes to DiL12LG [RL12LG] ↔ [DiL12LG];   {SumM} , {RL12LG} , {SumM}
 
 RL00UU dimerizes to DaL00UU [RL00UU] ↔ [DaL00UU];   {SumML} , {RL00UU} , {SumML}
 
 RL10UU dimerizes to DaL10UU [RL10UU] ↔ [DaL10UU];   {SumML} , {RL10UU} , {SumML}
 
 RL10CU dimerizes to DaL10CU [RL10CU] ↔ [DaL10CU];   {SumML} , {RL10CU} , {SumML}
 
 RL10LU dimerizes to DaL10LU [RL10LU] ↔ [DaL10LU];   {SumML} , {RL10LU} , {SumML}
 
 RL01UU dimerizes to DaL01UU [RL01UU] ↔ [DaL01UU];   {SumML} , {RL01UU} , {SumML}
 
 RL01UG dimerizes to DaL01UG [RL01UG] ↔ [DaL01UG];   {SumML} , {RL01UG} , {SumML}
 
 RL01UL dimerizes to DaL01UL [RL01UL] ↔ [DaL01UL];   {SumML} , {RL01UL} , {SumML}
 
 RL11UU dimerizes to DaL11UU [RL11UU] ↔ [DaL11UU];   {SumML} , {RL11UU} , {SumML}
 
 RL11CU dimerizes to DaL11CU [RL11CU] ↔ [DaL11CU];   {SumML} , {RL11CU} , {SumML}
 
 RL11LU dimerizes to DaL11LU [RL11LU] ↔ [DaL11LU];   {SumML} , {RL11LU} , {SumML}
 
 RL11UG dimerizes to DaL11UG [RL11UG] ↔ [DaL11UG];   {SumML} , {RL11UG} , {SumML}
 
 RL11UL dimerizes to DaL11UL [RL11UL] ↔ [DaL11UL];   {SumML} , {RL11UL} , {SumML}
 
 RL11CG dimerizes to DaL11CG [RL11CG] ↔ [DaL11CG];   {SumML} , {RL11CG} , {SumML}
 
 RL11CC dimerizes to DaL11CC [RL11CC] ↔ [DaL11CC];   {SumML} , {RL11CC} , {SumML}
 
 RL11LG dimerizes to DaL11LG [RL11LG] ↔ [DaL11LG];   {SumML} , {RL11LG} , {SumML}
 
 RL02UU dimerizes to DaL02UU [RL02UU] ↔ [DaL02UU];   {SumML} , {RL02UU} , {SumML}
 
 RL02UG dimerizes to DaL02UG [RL02UG] ↔ [DaL02UG];   {SumML} , {RL02UG} , {SumML}
 
 RL02UL dimerizes to DaL02UL [RL02UL] ↔ [DaL02UL];   {SumML} , {RL02UL} , {SumML}
 
 RL12UU dimerizes to DaL12UU [RL12UU] ↔ [DaL12UU];   {SumML} , {RL12UU} , {SumML}
 
 RL12CU dimerizes to DaL12CU [RL12CU] ↔ [DaL12CU];   {SumML} , {RL12CU} , {SumML}
 
 RL12LU dimerizes to DaL12LU [RL12LU] ↔ [DaL12LU];   {SumML} , {RL12LU} , {SumML}
 
 RL12UG dimerizes to DaL12UG [RL12UG] ↔ [DaL12UG];   {SumML} , {RL12UG} , {SumML}
 
 RL12UL dimerizes to DaL12UL [RL12UL] ↔ [DaL12UL];   {SumML} , {RL12UL} , {SumML}
 
 RL12CG dimerizes to DaL12CG [RL12CG] ↔ [DaL12CG];   {SumML} , {RL12CG} , {SumML}
 
 RL12CC dimerizes to DaL12CC [RL12CC] ↔ [DaL12CC];   {SumML} , {RL12CC} , {SumML}
 
 RL12LG dimerizes to DaL12LG [RL12LG] ↔ [DaL12LG];   {SumML} , {RL12LG} , {SumML}
 
 Di00UU loses partner [Di00UU] ↔ [R00UU];   {Di00UU}
 
 Di10UU loses partner [Di10UU] ↔ [R10UU];   {Di10UU}
 
 Di10CU loses partner [Di10CU] ↔ [R10CU];   {Di10CU}
 
 Di10LU loses partner [Di10LU] ↔ [R10LU];   {Di10LU}
 
 Di01UU loses partner [Di01UU] ↔ [R01UU];   {Di01UU}
 
 Di01UG loses partner [Di01UG] ↔ [R01UG];   {Di01UG}
 
 Di01UL loses partner [Di01UL] ↔ [R01UL];   {Di01UL}
 
 Di11UU loses partner [Di11UU] ↔ [R11UU];   {Di11UU}
 
 Di11CU loses partner [Di11CU] ↔ [R11CU];   {Di11CU}
 
 Di11LU loses partner [Di11LU] ↔ [R11LU];   {Di11LU}
 
 Di11UG loses partner [Di11UG] ↔ [R11UG];   {Di11UG}
 
 Di11UL loses partner [Di11UL] ↔ [R11UL];   {Di11UL}
 
 Di11CG loses partner [Di11CG] ↔ [R11CG];   {Di11CG}
 
 Di11CC loses partner [Di11CC] ↔ [R11CC];   {Di11CC}
 
 Di11LG loses partner [Di11LG] ↔ [R11LG];   {Di11LG}
 
 Di02UU loses partner [Di02UU] ↔ [R02UU];   {Di02UU}
 
 Di02UG loses partner [Di02UG] ↔ [R02UG];   {Di02UG}
 
 Di02UL loses partner [Di02UL] ↔ [R02UL];   {Di02UL}
 
 Di12UU loses partner [Di12UU] ↔ [R12UU];   {Di12UU}
 
 Di12CU loses partner [Di12CU] ↔ [R12CU];   {Di12CU}
 
 Di12LU loses partner [Di12LU] ↔ [R12LU];   {Di12LU}
 
 Di12UG loses partner [Di12UG] ↔ [R12UG];   {Di12UG}
 
 Di12UL loses partner [Di12UL] ↔ [R12UL];   {Di12UL}
 
 Di12CG loses partner [Di12CG] ↔ [R12CG];   {Di12CG}
 
 Di12CC loses partner [Di12CC] ↔ [R12CC];   {Di12CC}
 
 Di12LG loses partner [Di12LG] ↔ [R12LG];   {Di12LG}
 
 DiL00UU loses partner [DiL00UU] ↔ [RL00UU];   {DiL00UU}
 
 DiL10UU loses partner [DiL10UU] ↔ [RL10UU];   {DiL10UU}
 
 DiL10CU loses partner [DiL10CU] ↔ [RL10CU];   {DiL10CU}
 
 DiL10LU loses partner [DiL10LU] ↔ [RL10LU];   {DiL10LU}
 
 DiL01UU loses partner [DiL01UU] ↔ [RL01UU];   {DiL01UU}
 
 DiL01UG loses partner [DiL01UG] ↔ [RL01UG];   {DiL01UG}
 
 DiL01UL loses partner [DiL01UL] ↔ [RL01UL];   {DiL01UL}
 
 DiL11UU loses partner [DiL11UU] ↔ [RL11UU];   {DiL11UU}
 
 DiL11CU loses partner [DiL11CU] ↔ [RL11CU];   {DiL11CU}
 
 DiL11LU loses partner [DiL11LU] ↔ [RL11LU];   {DiL11LU}
 
 DiL11UG loses partner [DiL11UG] ↔ [RL11UG];   {DiL11UG}
 
 DiL11UL loses partner [DiL11UL] ↔ [RL11UL];   {DiL11UL}
 
 DiL11CG loses partner [DiL11CG] ↔ [RL11CG];   {DiL11CG}
 
 DiL11CC loses partner [DiL11CC] ↔ [RL11CC];   {DiL11CC}
 
 DiL11LG loses partner [DiL11LG] ↔ [RL11LG];   {DiL11LG}
 
 DiL02UU loses partner [DiL02UU] ↔ [RL02UU];   {DiL02UU}
 
 DiL02UG loses partner [DiL02UG] ↔ [RL02UG];   {DiL02UG}
 
 DiL02UL loses partner [DiL02UL] ↔ [RL02UL];   {DiL02UL}
 
 DiL12UU loses partner [DiL12UU] ↔ [RL12UU];   {DiL12UU}
 
 DiL12CU loses partner [DiL12CU] ↔ [RL12CU];   {DiL12CU}
 
 DiL12LU loses partner [DiL12LU] ↔ [RL12LU];   {DiL12LU}
 
 DiL12UG loses partner [DiL12UG] ↔ [RL12UG];   {DiL12UG}
 
 DiL12UL loses partner [DiL12UL] ↔ [RL12UL];   {DiL12UL}
 
 DiL12CG loses partner [DiL12CG] ↔ [RL12CG];   {DiL12CG}
 
 DiL12CC loses partner [DiL12CC] ↔ [RL12CC];   {DiL12CC}
 
 DiL12LG loses partner [DiL12LG] ↔ [RL12LG];   {DiL12LG}
 
 Da00UU loses partner [Da00UU] ↔ [R00UU];   {Da00UU}
 
 Da10UU loses partner [Da10UU] ↔ [R10UU];   {Da10UU}
 
 Da10CU loses partner [Da10CU] ↔ [R10CU];   {Da10CU}
 
 Da10LU loses partner [Da10LU] ↔ [R10LU];   {Da10LU}
 
 Da01UU loses partner [Da01UU] ↔ [R01UU];   {Da01UU}
 
 Da01UG loses partner [Da01UG] ↔ [R01UG];   {Da01UG}
 
 Da01UL loses partner [Da01UL] ↔ [R01UL];   {Da01UL}
 
 Da11UU loses partner [Da11UU] ↔ [R11UU];   {Da11UU}
 
 Da11CU loses partner [Da11CU] ↔ [R11CU];   {Da11CU}
 
 Da11LU loses partner [Da11LU] ↔ [R11LU];   {Da11LU}
 
 Da11UG loses partner [Da11UG] ↔ [R11UG];   {Da11UG}
 
 Da11UL loses partner [Da11UL] ↔ [R11UL];   {Da11UL}
 
 Da11CG loses partner [Da11CG] ↔ [R11CG];   {Da11CG}
 
 Da11CC loses partner [Da11CC] ↔ [R11CC];   {Da11CC}
 
 Da11LG loses partner [Da11LG] ↔ [R11LG];   {Da11LG}
 
 Da02UU loses partner [Da02UU] ↔ [R02UU];   {Da02UU}
 
 Da02UG loses partner [Da02UG] ↔ [R02UG];   {Da02UG}
 
 Da02UL loses partner [Da02UL] ↔ [R02UL];   {Da02UL}
 
 Da12UU loses partner [Da12UU] ↔ [R12UU];   {Da12UU}
 
 Da12CU loses partner [Da12CU] ↔ [R12CU];   {Da12CU}
 
 Da12LU loses partner [Da12LU] ↔ [R12LU];   {Da12LU}
 
 Da12UG loses partner [Da12UG] ↔ [R12UG];   {Da12UG}
 
 Da12UL loses partner [Da12UL] ↔ [R12UL];   {Da12UL}
 
 Da12CG loses partner [Da12CG] ↔ [R12CG];   {Da12CG}
 
 Da12CC loses partner [Da12CC] ↔ [R12CC];   {Da12CC}
 
 Da12LG loses partner [Da12LG] ↔ [R12LG];   {Da12LG}
 
 DaL00UU loses partner [DaL00UU] ↔ [RL00UU];   {DaL00UU}
 
 DaL10UU loses partner [DaL10UU] ↔ [RL10UU];   {DaL10UU}
 
 DaL10CU loses partner [DaL10CU] ↔ [RL10CU];   {DaL10CU}
 
 DaL10LU loses partner [DaL10LU] ↔ [RL10LU];   {DaL10LU}
 
 DaL01UU loses partner [DaL01UU] ↔ [RL01UU];   {DaL01UU}
 
 DaL01UG loses partner [DaL01UG] ↔ [RL01UG];   {DaL01UG}
 
 DaL01UL loses partner [DaL01UL] ↔ [RL01UL];   {DaL01UL}
 
 DaL11UU loses partner [DaL11UU] ↔ [RL11UU];   {DaL11UU}
 
 DaL11CU loses partner [DaL11CU] ↔ [RL11CU];   {DaL11CU}
 
 DaL11LU loses partner [DaL11LU] ↔ [RL11LU];   {DaL11LU}
 
 DaL11UG loses partner [DaL11UG] ↔ [RL11UG];   {DaL11UG}
 
 DaL11UL loses partner [DaL11UL] ↔ [RL11UL];   {DaL11UL}
 
 DaL11CG loses partner [DaL11CG] ↔ [RL11CG];   {DaL11CG}
 
 DaL11CC loses partner [DaL11CC] ↔ [RL11CC];   {DaL11CC}
 
 DaL11LG loses partner [DaL11LG] ↔ [RL11LG];   {DaL11LG}
 
 DaL02UU loses partner [DaL02UU] ↔ [RL02UU];   {DaL02UU}
 
 DaL02UG loses partner [DaL02UG] ↔ [RL02UG];   {DaL02UG}
 
 DaL02UL loses partner [DaL02UL] ↔ [RL02UL];   {DaL02UL}
 
 DaL12UU loses partner [DaL12UU] ↔ [RL12UU];   {DaL12UU}
 
 DaL12CU loses partner [DaL12CU] ↔ [RL12CU];   {DaL12CU}
 
 DaL12LU loses partner [DaL12LU] ↔ [RL12LU];   {DaL12LU}
 
 DaL12UG loses partner [DaL12UG] ↔ [RL12UG];   {DaL12UG}
 
 DaL12UL loses partner [DaL12UL] ↔ [RL12UL];   {DaL12UL}
 
 DaL12CG loses partner [DaL12CG] ↔ [RL12CG];   {DaL12CG}
 
 DaL12CC loses partner [DaL12CC] ↔ [RL12CC];   {DaL12CC}
 
 DaL12LG loses partner [DaL12LG] ↔ [RL12LG];   {DaL12LG}
 
 R00UU extra homodimerizes to Di00UU [R00UU] ↔ [Di00UU];   {R00UU}
 
 R10UU extra homodimerizes to Di10UU [R10UU] ↔ [Di10UU];   {R10UU}
 
 R10CU extra homodimerizes to Di10CU [R10CU] ↔ [Di10CU];   {R10CU}
 
 R10LU extra homodimerizes to Di10LU [R10LU] ↔ [Di10LU];   {R10LU}
 
 R01UU extra homodimerizes to Di01UU [R01UU] ↔ [Di01UU];   {R01UU}
 
 R01UG extra homodimerizes to Di01UG [R01UG] ↔ [Di01UG];   {R01UG}
 
 R01UL extra homodimerizes to Di01UL [R01UL] ↔ [Di01UL];   {R01UL}
 
 R11UU extra homodimerizes to Di11UU [R11UU] ↔ [Di11UU];   {R11UU}
 
 R11CU extra homodimerizes to Di11CU [R11CU] ↔ [Di11CU];   {R11CU}
 
 R11LU extra homodimerizes to Di11LU [R11LU] ↔ [Di11LU];   {R11LU}
 
 R11UG extra homodimerizes to Di11UG [R11UG] ↔ [Di11UG];   {R11UG}
 
 R11UL extra homodimerizes to Di11UL [R11UL] ↔ [Di11UL];   {R11UL}
 
 R11CG extra homodimerizes to Di11CG [R11CG] ↔ [Di11CG];   {R11CG}
 
 R11CC extra homodimerizes to Di11CC [R11CC] ↔ [Di11CC];   {R11CC}
 
 R11LG extra homodimerizes to Di11LG [R11LG] ↔ [Di11LG];   {R11LG}
 
 R02UU extra homodimerizes to Di02UU [R02UU] ↔ [Di02UU];   {R02UU}
 
 R02UG extra homodimerizes to Di02UG [R02UG] ↔ [Di02UG];   {R02UG}
 
 R02UL extra homodimerizes to Di02UL [R02UL] ↔ [Di02UL];   {R02UL}
 
 R12UU extra homodimerizes to Di12UU [R12UU] ↔ [Di12UU];   {R12UU}
 
 R12CU extra homodimerizes to Di12CU [R12CU] ↔ [Di12CU];   {R12CU}
 
 R12LU extra homodimerizes to Di12LU [R12LU] ↔ [Di12LU];   {R12LU}
 
 R12UG extra homodimerizes to Di12UG [R12UG] ↔ [Di12UG];   {R12UG}
 
 R12UL extra homodimerizes to Di12UL [R12UL] ↔ [Di12UL];   {R12UL}
 
 R12CG extra homodimerizes to Di12CG [R12CG] ↔ [Di12CG];   {R12CG}
 
 R12CC extra homodimerizes to Di12CC [R12CC] ↔ [Di12CC];   {R12CC}
 
 R12LG extra homodimerizes to Di12LG [R12LG] ↔ [Di12LG];   {R12LG}
 
 RL00UU extra homodimerizes to DaL00UU [RL00UU] ↔ [DaL00UU];   {RL00UU}
 
 RL10UU extra homodimerizes to DaL10UU [RL10UU] ↔ [DaL10UU];   {RL10UU}
 
 RL10CU extra homodimerizes to DaL10CU [RL10CU] ↔ [DaL10CU];   {RL10CU}
 
 RL10LU extra homodimerizes to DaL10LU [RL10LU] ↔ [DaL10LU];   {RL10LU}
 
 RL01UU extra homodimerizes to DaL01UU [RL01UU] ↔ [DaL01UU];   {RL01UU}
 
 RL01UG extra homodimerizes to DaL01UG [RL01UG] ↔ [DaL01UG];   {RL01UG}
 
 RL01UL extra homodimerizes to DaL01UL [RL01UL] ↔ [DaL01UL];   {RL01UL}
 
 RL11UU extra homodimerizes to DaL11UU [RL11UU] ↔ [DaL11UU];   {RL11UU}
 
 RL11CU extra homodimerizes to DaL11CU [RL11CU] ↔ [DaL11CU];   {RL11CU}
 
 RL11LU extra homodimerizes to DaL11LU [RL11LU] ↔ [DaL11LU];   {RL11LU}
 
 RL11UG extra homodimerizes to DaL11UG [RL11UG] ↔ [DaL11UG];   {RL11UG}
 
 RL11UL extra homodimerizes to DaL11UL [RL11UL] ↔ [DaL11UL];   {RL11UL}
 
 RL11CG extra homodimerizes to DaL11CG [RL11CG] ↔ [DaL11CG];   {RL11CG}
 
 RL11CC extra homodimerizes to DaL11CC [RL11CC] ↔ [DaL11CC];   {RL11CC}
 
 RL11LG extra homodimerizes to DaL11LG [RL11LG] ↔ [DaL11LG];   {RL11LG}
 
 RL02UU extra homodimerizes to DaL02UU [RL02UU] ↔ [DaL02UU];   {RL02UU}
 
 RL02UG extra homodimerizes to DaL02UG [RL02UG] ↔ [DaL02UG];   {RL02UG}
 
 RL02UL extra homodimerizes to DaL02UL [RL02UL] ↔ [DaL02UL];   {RL02UL}
 
 RL12UU extra homodimerizes to DaL12UU [RL12UU] ↔ [DaL12UU];   {RL12UU}
 
 RL12CU extra homodimerizes to DaL12CU [RL12CU] ↔ [DaL12CU];   {RL12CU}
 
 RL12LU extra homodimerizes to DaL12LU [RL12LU] ↔ [DaL12LU];   {RL12LU}
 
 RL12UG extra homodimerizes to DaL12UG [RL12UG] ↔ [DaL12UG];   {RL12UG}
 
 RL12UL extra homodimerizes to DaL12UL [RL12UL] ↔ [DaL12UL];   {RL12UL}
 
 RL12CG extra homodimerizes to DaL12CG [RL12CG] ↔ [DaL12CG];   {RL12CG}
 
 RL12CC extra homodimerizes to DaL12CC [RL12CC] ↔ [DaL12CC];   {RL12CC}
 
 RL12LG extra homodimerizes to DaL12LG [RL12LG] ↔ [DaL12LG];   {RL12LG}
 
Rules (25)
 
 Assignment Rule (name: Ke1) Ke1 = K*Ke/K1
 
 Assignment Rule (name: K45P) K45P = K45/floc
 
 Assignment Rule (name: KcgP) KcgP = Kcg/floc
 
 Assignment Rule (name: ku) ku = kb*K
 
 Assignment Rule (name: ko) ko = kc/Ke
 
 Assignment Rule (name: k1b) k1b = k1u/K1
 
 Assignment Rule (name: k1o) k1o = k1c/Ke1
 
 Assignment Rule (name: kkin68) kkin68 = kkin
 
 Assignment Rule (name: kptp68) kptp68 = kptp
 
 Assignment Rule (name: kb45) kb45 = ku45/K45
 
 Assignment Rule (name: kb68) kb68 = kb45
 
 Assignment Rule (name: ku68) ku68 = ku45
 
 Assignment Rule (name: kbcg) kbcg = kucg/Kcg
 
 Assignment Rule (name: ku45M) ku45M = ku45
 
 Assignment Rule (name: kb45P) kb45P = ku45M/K45P
 
 Assignment Rule (name: kb68P) kb68P = kb45P
 
 Assignment Rule (name: ku68M) ku68M = ku45M
 
 Assignment Rule (name: kucgM) kucgM = kucg
 
 Assignment Rule (name: kbcgP) kbcgP = kucgM/KcgP
 
 Assignment Rule (name: SumM) SumM = R00UU+R10UU+R10CU+R10LU+R01UU+R01UG+R01UL+R11UU+R11CU+R11LU+R11UG+R11UL+R11CG+R11CC+R11LG+R02UU+R02UG+R02UL+R12UU+R12CU+R12LU+R12UG+R12UL+R12CG+R12CC+R12LG
 
 Assignment Rule (name: SumML) SumML = RL00UU+RL10UU+RL10CU+RL10LU+RL01UU+RL01UG+RL01UL+RL11UU+RL11CU+RL11LU+RL11UG+RL11UL+RL11CG+RL11CC+RL11LG+RL02UU+RL02UG+RL02UL+RL12UU+RL12CU+RL12LU+RL12UG+RL12UL+RL12CG+RL12CC+RL12LG
 
 Assignment Rule (name: PY) PY = Rc10UU+Rc10CU+Rc10LU+RcL10UU+RcL10CU+RcL10LU+R10UU+R10CU+R10LU+RL10UU+RL10CU+RL10LU+Di10UU+Di10CU+Di10LU+Da10UU+Da10CU+Da10LU+DiL10UU+DiL10CU+DiL10LU+DaL10UU+DaL10CU+DaL10LU+1*(Rc01UU+Rc01UG+Rc01UL+RcL01UU+RcL01UG+RcL01UL+R01UU+R01UG+R01UL+RL01UU+RL01UG+RL01UL+Di01UU+Di01UG+Di01UL+Da01UU+Da01UG+Da01UL+DiL01UU+DiL01UG+DiL01UL+DaL01UU+DaL01UG+DaL01UL)+2*(Rc11UU+Rc11CU+Rc11LU+Rc11UG+Rc11UL+Rc11CG+Rc11CC+Rc11LG+RcL11UU+RcL11CU+RcL11LU+RcL11UG+RcL11UL+RcL11CG+RcL11CC+RcL11LG+R11UU+R11CU+R11LU+R11UG+R11UL+R11CG+R11CC+R11LG+RL11UU+RL11CU+RL11LU+RL11UG+RL11UL+RL11CG+RL11CC+RL11LG+Di11UU+Di11CU+Di11LU+Di11UG+Di11UL+Di11CG+Di11CC+Di11LG+Da11UU+Da11CU+Da11LU+Da11UG+Da11UL+Da11CG+Da11CC+Da11LG+DiL11UU+DiL11CU+DiL11LU+DiL11UG+DiL11UL+DiL11CG+DiL11CC+DiL11LG+DaL11UU+DaL11CU+DaL11LU+DaL11UG+DaL11UL+DaL11CG+DaL11CC+DaL11LG)+2*(Rc02UU+Rc02UG+Rc02UL+RcL02UU+RcL02UG+RcL02UL+R02UU+R02UG+R02UL+RL02UU+RL02UG+RL02UL+Di02UU+Di02UG+Di02UL+Da02UU+Da02UG+Da02UL+DiL02UU+DiL02UG+DiL02UL+DaL02UU+DaL02UG+DaL02UL)+3*(Rc12UU+Rc12CU+Rc12LU+Rc12UG+Rc12UL+Rc12CG+Rc12CC+Rc12LG+RcL12UU+RcL12CU+RcL12LU+RcL12UG+RcL12UL+RcL12CG+RcL12CC+RcL12LG+R12UU+R12CU+R12LU+R12UG+R12UL+R12CG+R12CC+R12LG+RL12UU+RL12CU+RL12LU+RL12UG+RL12UL+RL12CG+RL12CC+RL12LG+Di12UU+Di12CU+Di12LU+Di12UG+Di12UL+Di12CG+Di12CC+Di12LG+Da12UU+Da12CU+Da12LU+Da12UG+Da12UL+Da12CG+Da12CC+Da12LG+DiL12UU+DiL12CU+DiL12LU+DiL12UG+DiL12UL+DiL12CG+DiL12CC+DiL12LG+DaL12UU+DaL12CU+DaL12LU+DaL12UG+DaL12UL+DaL12CG+DaL12CC+DaL12LG)
 
 Assignment Rule (name: Ub) Ub = Rc11CC+Rc12CC+RcL11CC+RcL12CC+R11CC+R12CC+RL11CC+RL12CC+Di11CC+Di12CC+Da11CC+Da12CC+DiL11CC+DiL12CC+DaL11CC+DaL12CC+Rc10CU+Rc11CU+Rc12CU+RcL10CU+RcL11CU+RcL12CU+R10CU+R11CU+R12CU+RL10CU+RL11CU+RL12CU+Di10CU+Di11CU+Di12CU+Da10CU+Da11CU+Da12CU+DiL10CU+DiL11CU+DiL12CU+DaL10CU+DaL11CU+DaL12CU+Rc10LU+Rc11LU+Rc12LU+RcL10LU+RcL11LU+RcL12LU+R10LU+R11LU+R12LU+RL10LU+RL11LU+RL12LU+Di10LU+Di11LU+Di12LU+Da10LU+Da11LU+Da12LU+DiL10LU+DiL11LU+DiL12LU+DaL10LU+DaL11LU+DaL12LU+Rc11CG+Rc12CG+RcL11CG+RcL12CG+R11CG+R12CG+RL11CG+RL12CG+Di11CG+Di12CG+Da11CG+Da12CG+DiL11CG+DiL12CG+DaL11CG+DaL12CG+Rc11LG+Rc12LG+RcL11LG+RcL12LG+R11LG+R12LG+RL11LG+RL12LG+Di11LG+Di12LG+Da11LG+Da12LG+DiL11LG+DiL12LG+DaL11LG+DaL12LG
 
 Assignment Rule (name: PYNorm) PYNorm = PY/PYMax
 
 Assignment Rule (name: UbNorm) UbNorm = Ub/(UbMax*CblFactor)
 
   cell Spatial dimensions: 3.0  Compartment size: 1.0
 
 L
Compartment: cell
Initial concentration: 0.0
 
 Cbl
Compartment: cell
Initial concentration: 2.80975332814237E-5
 
 Grb2
Compartment: cell
Initial concentration: 3.32
 
 CG
Compartment: cell
Initial concentration: 0.0146119024667186
 
   PY
Compartment: cell
 
   Ub
Compartment: cell
 
   PYNorm
Compartment: cell
 
   UbNorm
Compartment: cell
 
   SumM
Compartment: cell
 
   SumML
Compartment: cell
 
 Rc00UU
Compartment: cell
Initial concentration: 0.652109629206172
 
   Rc10UU
Compartment: cell
Initial concentration: 0.0
 
   Rc10CU
Compartment: cell
Initial concentration: 0.0
 
   Rc10LU
Compartment: cell
Initial concentration: 0.0
 
   Rc01UU
Compartment: cell
Initial concentration: 0.0
 
   Rc01UG
Compartment: cell
Initial concentration: 0.0
 
   Rc01UL
Compartment: cell
Initial concentration: 0.0
 
   Rc11UU
Compartment: cell
Initial concentration: 0.0
 
   Rc11CU
Compartment: cell
Initial concentration: 0.0
 
   Rc11LU
Compartment: cell
Initial concentration: 0.0
 
   Rc11UG
Compartment: cell
Initial concentration: 0.0
 
   Rc11UL
Compartment: cell
Initial concentration: 0.0
 
   Rc11CG
Compartment: cell
Initial concentration: 0.0
 
   Rc11CC
Compartment: cell
Initial concentration: 0.0
 
   Rc11LG
Compartment: cell
Initial concentration: 0.0
 
   Rc02UU
Compartment: cell
Initial concentration: 0.0
 
   Rc02UG
Compartment: cell
Initial concentration: 0.0
 
   Rc02UL
Compartment: cell
Initial concentration: 0.0
 
   Rc12UU
Compartment: cell
Initial concentration: 0.0
 
   Rc12CU
Compartment: cell
Initial concentration: 0.0
 
   Rc12LU
Compartment: cell
Initial concentration: 0.0
 
   Rc12UG
Compartment: cell
Initial concentration: 0.0
 
   Rc12UL
Compartment: cell
Initial concentration: 0.0
 
   Rc12CG
Compartment: cell
Initial concentration: 0.0
 
   Rc12CC
Compartment: cell
Initial concentration: 0.0
 
   Rc12LG
Compartment: cell
Initial concentration: 0.0
 
   RcL00UU
Compartment: cell
Initial concentration: 0.0
 
   RcL10UU
Compartment: cell
Initial concentration: 0.0
 
   RcL10CU
Compartment: cell
Initial concentration: 0.0
 
   RcL10LU
Compartment: cell
Initial concentration: 0.0
 
   RcL01UU
Compartment: cell
Initial concentration: 0.0
 
   RcL01UG
Compartment: cell
Initial concentration: 0.0
 
   RcL01UL
Compartment: cell
Initial concentration: 0.0
 
   RcL11UU
Compartment: cell
Initial concentration: 0.0
 
   RcL11CU
Compartment: cell
Initial concentration: 0.0
 
   RcL11LU
Compartment: cell
Initial concentration: 0.0
 
   RcL11UG
Compartment: cell
Initial concentration: 0.0
 
   RcL11UL
Compartment: cell
Initial concentration: 0.0
 
   RcL11CG
Compartment: cell
Initial concentration: 0.0
 
   RcL11CC
Compartment: cell
Initial concentration: 0.0
 
   RcL11LG
Compartment: cell
Initial concentration: 0.0
 
   RcL02UU
Compartment: cell
Initial concentration: 0.0
 
   RcL02UG
Compartment: cell
Initial concentration: 0.0
 
   RcL02UL
Compartment: cell
Initial concentration: 0.0
 
   RcL12UU
Compartment: cell
Initial concentration: 0.0
 
   RcL12CU
Compartment: cell
Initial concentration: 0.0
 
   RcL12LU
Compartment: cell
Initial concentration: 0.0
 
   RcL12UG
Compartment: cell
Initial concentration: 0.0
 
   RcL12UL
Compartment: cell
Initial concentration: 0.0
 
   RcL12CG
Compartment: cell
Initial concentration: 0.0
 
   RcL12CC
Compartment: cell
Initial concentration: 0.0
 
   RcL12LG
Compartment: cell
Initial concentration: 0.0
 
   R00UU
Compartment: cell
Initial concentration: 0.0203784259126929
 
   R10UU
Compartment: cell
Initial concentration: 0.0
 
   R10CU
Compartment: cell
Initial concentration: 0.0
 
   R10LU
Compartment: cell
Initial concentration: 0.0
 
   R01UU
Compartment: cell
Initial concentration: 0.0
 
   R01UG
Compartment: cell
Initial concentration: 0.0
 
   R01UL
Compartment: cell
Initial concentration: 0.0
 
   R11UU
Compartment: cell
Initial concentration: 0.0
 
   R11CU
Compartment: cell
Initial concentration: 0.0
 
   R11LU
Compartment: cell
Initial concentration: 0.0
 
   R11UG
Compartment: cell
Initial concentration: 0.0
 
   R11UL
Compartment: cell
Initial concentration: 0.0
 
   R11CG
Compartment: cell
Initial concentration: 0.0
 
   R11CC
Compartment: cell
Initial concentration: 0.0
 
   R11LG
Compartment: cell
Initial concentration: 0.0
 
   R02UU
Compartment: cell
Initial concentration: 0.0
 
   R02UG
Compartment: cell
Initial concentration: 0.0
 
   R02UL
Compartment: cell
Initial concentration: 0.0
 
   R12UU
Compartment: cell
Initial concentration: 0.0
 
   R12CU
Compartment: cell
Initial concentration: 0.0
 
   R12LU
Compartment: cell
Initial concentration: 0.0
 
   R12UG
Compartment: cell
Initial concentration: 0.0
 
   R12UL
Compartment: cell
Initial concentration: 0.0
 
   R12CG
Compartment: cell
Initial concentration: 0.0
 
   R12CC
Compartment: cell
Initial concentration: 0.0
 
   R12LG
Compartment: cell
Initial concentration: 0.0
 
   RL00UU
Compartment: cell
Initial concentration: 0.0
 
   RL10UU
Compartment: cell
Initial concentration: 0.0
 
   RL10CU
Compartment: cell
Initial concentration: 0.0
 
   RL10LU
Compartment: cell
Initial concentration: 0.0
 
   RL01UU
Compartment: cell
Initial concentration: 0.0
 
   RL01UG
Compartment: cell
Initial concentration: 0.0
 
   RL01UL
Compartment: cell
Initial concentration: 0.0
 
   RL11UU
Compartment: cell
Initial concentration: 0.0
 
   RL11CU
Compartment: cell
Initial concentration: 0.0
 
   RL11LU
Compartment: cell
Initial concentration: 0.0
 
   RL11UG
Compartment: cell
Initial concentration: 0.0
 
   RL11UL
Compartment: cell
Initial concentration: 0.0
 
   RL11CG
Compartment: cell
Initial concentration: 0.0
 
   RL11CC
Compartment: cell
Initial concentration: 0.0
 
   RL11LG
Compartment: cell
Initial concentration: 0.0
 
   RL02UU
Compartment: cell
Initial concentration: 0.0
 
   RL02UG
Compartment: cell
Initial concentration: 0.0
 
   RL02UL
Compartment: cell
Initial concentration: 0.0
 
   RL12UU
Compartment: cell
Initial concentration: 0.0
 
   RL12CU
Compartment: cell
Initial concentration: 0.0
 
   RL12LU
Compartment: cell
Initial concentration: 0.0
 
   RL12UG
Compartment: cell
Initial concentration: 0.0
 
   RL12UL
Compartment: cell
Initial concentration: 0.0
 
   RL12CG
Compartment: cell
Initial concentration: 0.0
 
   RL12CC
Compartment: cell
Initial concentration: 0.0
 
   RL12LG
Compartment: cell
Initial concentration: 0.0
 
 Di00UU
Compartment: cell
Initial concentration: 0.157511944881135
 
   Di10UU
Compartment: cell
Initial concentration: 0.0
 
   Di10CU
Compartment: cell
Initial concentration: 0.0
 
   Di10LU
Compartment: cell
Initial concentration: 0.0
 
   Di01UU
Compartment: cell
Initial concentration: 0.0
 
   Di01UG
Compartment: cell
Initial concentration: 0.0
 
   Di01UL
Compartment: cell
Initial concentration: 0.0
 
   Di11UU
Compartment: cell
Initial concentration: 0.0
 
   Di11CU
Compartment: cell
Initial concentration: 0.0
 
   Di11LU
Compartment: cell
Initial concentration: 0.0
 
   Di11UG
Compartment: cell
Initial concentration: 0.0
 
   Di11UL
Compartment: cell
Initial concentration: 0.0
 
   Di11CG
Compartment: cell
Initial concentration: 0.0
 
   Di11CC
Compartment: cell
Initial concentration: 0.0
 
   Di11LG
Compartment: cell
Initial concentration: 0.0
 
   Di02UU
Compartment: cell
Initial concentration: 0.0
 
   Di02UG
Compartment: cell
Initial concentration: 0.0
 
   Di02UL
Compartment: cell
Initial concentration: 0.0
 
   Di12UU
Compartment: cell
Initial concentration: 0.0
 
   Di12CU
Compartment: cell
Initial concentration: 0.0
 
   Di12LU
Compartment: cell
Initial concentration: 0.0
 
   Di12UG
Compartment: cell
Initial concentration: 0.0
 
   Di12UL
Compartment: cell
Initial concentration: 0.0
 
   Di12CG
Compartment: cell
Initial concentration: 0.0
 
   Di12CC
Compartment: cell
Initial concentration: 0.0
 
   Di12LG
Compartment: cell
Initial concentration: 0.0
 
   Da00UU
Compartment: cell
Initial concentration: 0.0
 
   Da10UU
Compartment: cell
Initial concentration: 0.0
 
   Da10CU
Compartment: cell
Initial concentration: 0.0
 
   Da10LU
Compartment: cell
Initial concentration: 0.0
 
   Da01UU
Compartment: cell
Initial concentration: 0.0
 
   Da01UG
Compartment: cell
Initial concentration: 0.0
 
   Da01UL
Compartment: cell
Initial concentration: 0.0
 
   Da11UU
Compartment: cell
Initial concentration: 0.0
 
   Da11CU
Compartment: cell
Initial concentration: 0.0
 
   Da11LU
Compartment: cell
Initial concentration: 0.0
 
   Da11UG
Compartment: cell
Initial concentration: 0.0
 
   Da11UL
Compartment: cell
Initial concentration: 0.0
 
   Da11CG
Compartment: cell
Initial concentration: 0.0
 
   Da11CC
Compartment: cell
Initial concentration: 0.0
 
   Da11LG
Compartment: cell
Initial concentration: 0.0
 
   Da02UU
Compartment: cell
Initial concentration: 0.0
 
   Da02UG
Compartment: cell
Initial concentration: 0.0
 
   Da02UL
Compartment: cell
Initial concentration: 0.0
 
   Da12UU
Compartment: cell
Initial concentration: 0.0
 
   Da12CU
Compartment: cell
Initial concentration: 0.0
 
   Da12LU
Compartment: cell
Initial concentration: 0.0
 
   Da12UG
Compartment: cell
Initial concentration: 0.0
 
   Da12UL
Compartment: cell
Initial concentration: 0.0
 
   Da12CG
Compartment: cell
Initial concentration: 0.0
 
   Da12CC
Compartment: cell
Initial concentration: 0.0
 
   Da12LG
Compartment: cell
Initial concentration: 0.0
 
   DiL00UU
Compartment: cell
Initial concentration: 0.0
 
   DiL10UU
Compartment: cell
Initial concentration: 0.0
 
   DiL10CU
Compartment: cell
Initial concentration: 0.0
 
   DiL10LU
Compartment: cell
Initial concentration: 0.0
 
   DiL01UU
Compartment: cell
Initial concentration: 0.0
 
   DiL01UG
Compartment: cell
Initial concentration: 0.0
 
   DiL01UL
Compartment: cell
Initial concentration: 0.0
 
   DiL11UU
Compartment: cell
Initial concentration: 0.0
 
   DiL11CU
Compartment: cell
Initial concentration: 0.0
 
   DiL11LU
Compartment: cell
Initial concentration: 0.0
 
   DiL11UG
Compartment: cell
Initial concentration: 0.0
 
   DiL11UL
Compartment: cell
Initial concentration: 0.0
 
   DiL11CG
Compartment: cell
Initial concentration: 0.0
 
   DiL11CC
Compartment: cell
Initial concentration: 0.0
 
   DiL11LG
Compartment: cell
Initial concentration: 0.0
 
   DiL02UU
Compartment: cell
Initial concentration: 0.0
 
   DiL02UG
Compartment: cell
Initial concentration: 0.0
 
   DiL02UL
Compartment: cell
Initial concentration: 0.0
 
   DiL12UU
Compartment: cell
Initial concentration: 0.0
 
   DiL12CU
Compartment: cell
Initial concentration: 0.0
 
   DiL12LU
Compartment: cell
Initial concentration: 0.0
 
   DiL12UG
Compartment: cell
Initial concentration: 0.0
 
   DiL12UL
Compartment: cell
Initial concentration: 0.0
 
   DiL12CG
Compartment: cell
Initial concentration: 0.0
 
   DiL12CC
Compartment: cell
Initial concentration: 0.0
 
   DiL12LG
Compartment: cell
Initial concentration: 0.0
 
   DaL00UU
Compartment: cell
Initial concentration: 0.0
 
   DaL10UU
Compartment: cell
Initial concentration: 0.0
 
   DaL10CU
Compartment: cell
Initial concentration: 0.0
 
   DaL10LU
Compartment: cell
Initial concentration: 0.0
 
   DaL01UU
Compartment: cell
Initial concentration: 0.0
 
   DaL01UG
Compartment: cell
Initial concentration: 0.0
 
   DaL01UL
Compartment: cell
Initial concentration: 0.0
 
   DaL11UU
Compartment: cell
Initial concentration: 0.0
 
   DaL11CU
Compartment: cell
Initial concentration: 0.0
 
   DaL11LU
Compartment: cell
Initial concentration: 0.0
 
   DaL11UG
Compartment: cell
Initial concentration: 0.0
 
   DaL11UL
Compartment: cell
Initial concentration: 0.0
 
   DaL11CG
Compartment: cell
Initial concentration: 0.0
 
   DaL11CC
Compartment: cell
Initial concentration: 0.0
 
   DaL11LG
Compartment: cell
Initial concentration: 0.0
 
   DaL02UU
Compartment: cell
Initial concentration: 0.0
 
   DaL02UG
Compartment: cell
Initial concentration: 0.0
 
   DaL02UL
Compartment: cell
Initial concentration: 0.0
 
   DaL12UU
Compartment: cell
Initial concentration: 0.0
 
   DaL12CU
Compartment: cell
Initial concentration: 0.0
 
   DaL12LU
Compartment: cell
Initial concentration: 0.0
 
   DaL12UG
Compartment: cell
Initial concentration: 0.0
 
   DaL12UL
Compartment: cell
Initial concentration: 0.0
 
   DaL12CG
Compartment: cell
Initial concentration: 0.0
 
   DaL12CC
Compartment: cell
Initial concentration: 0.0
 
   DaL12LG
Compartment: cell
Initial concentration: 0.0
 
Global Parameters (43)
 
   Ke1
Value: NaN
 
   K45P
Value: NaN
 
   KcgP
Value: NaN
 
   ku
Value: NaN
 
   ko
Value: NaN
 
   k1b
Value: NaN
 
   k1o
Value: NaN
 
   kptp68
Value: NaN
 
   kkin68
Value: NaN
 
   kb45
Value: NaN
 
   ku45M
Value: NaN
 
   kb45P
Value: NaN
 
   kb68
Value: NaN
 
   ku68
Value: NaN
 
   kb68P
Value: NaN
 
   ku68M
Value: NaN
 
   kbcg
Value: NaN
 
   kbcgP
Value: NaN
 
   kucgM
Value: NaN
 
   Ltot
Constant
 
   RT
Value: 0.83
Constant
 
   CblT
Value: 0.01464
Constant
 
   Grb2T
Value: 3.32
Constant
 
   K
Value: 3.38608
Constant
 
   Ke
Value: 32.0
Constant
 
   K1
Value: 52.0
Constant
 
   kptp
Value: 0.016
Constant
 
   kkin
Value: 0.289502
Constant
 
   K45
Value: 0.201361
Constant
 
   Kcg
Value: 0.006356
Constant
 
   ku45
Value: 0.001011
Constant
 
   kucg
Value: 0.309271
Constant
 
   kb
Value: 5.0
Constant
 
   kc
Value: 10.0
Constant
 
   kuDIM
Value: 1.0546
Constant
 
   kbDIM
Value: 200.0
Constant
 
   k1u
Value: 0.15
Constant
 
   k1c
Value: 10.0
Constant
 
   PYMax
Value: 2.34537527177036
Constant
 
   UbMax
Value: 0.014306
Constant
 
   floc
Value: 20000.0
Constant
 
   CblWT
Value: 0.01464
Constant
 
   CblFactor
Value: 1.0
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000595

Curator's comment: (updated: 11 Mar 2016 09:15:20 GMT)

Figure 6b in the paper. Parameter scan over EGF (L in model) and plot the values of UbNorm and TyrNorm after 120 seconds of simulation.

The model units for EGF (L) are nM (nano Molar), while to compare to experiments we converted them in ng/ml (the conversion factor is 0,17, i.e. 17 nM = 100 ng/ml).
spacer
spacer