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BIOMD0000000497 - Stanford2013 - Kinetic model of yeast metabolic network (regulation)

 

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Reference Publication
Publication ID: 24324546
Stanford NJ, Lubitz T, Smallbone K, Klipp E, Mendes P, Liebermeister W.
Systematic construction of kinetic models from genome-scale metabolic networks.
PLoS ONE 2013; 8(11): e79195
School of Computer Science, Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, United Kingdom.  [more]
Model
Original Model: BIOMD0000000497.origin
Submitter: Vijayalakshmi Chelliah
Submission ID: MODEL1307040000
Submission Date: 04 Jul 2013 10:28:54 UTC
Last Modification Date: 04 Apr 2014 15:00:01 UTC
Creation Date: 26 Nov 2013 12:56:29 UTC
Encoders:  Vijayalakshmi Chelliah
   Natalie Stanford
set #1
bqbiol:isVersionOf Gene Ontology metabolic process
Gene Ontology organic substance biosynthetic process
bqbiol:hasTaxon Taxonomy Saccharomyces cerevisiae
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
Notes
Stanford2013 - Kinetic model of yeast metabolic network (standard)

Large-scale model construction based on a logical layering of data such as reaction fluxes, metabolite concentrations, and kinetic constants. This model is built with regulatory information.

This model is described in the article:

Stanford NJ, Lubitz T, Smallbone K, Klipp E, Mendes P, Liebermeister W.
PLoS ONE 2013; 8(11): e79195

Abstract:

The quantitative effects of environmental and genetic perturbations on metabolism can be studied in silico using kinetic models. We present a strategy for large-scale model construction based on a logical layering of data such as reaction fluxes, metabolite concentrations, and kinetic constants. The resulting models contain realistic standard rate laws and plausible parameters, adhere to the laws of thermodynamics, and reproduce a predefined steady state. These features have not been simultaneously achieved by previous workflows. We demonstrate the advantages and limitations of the workflow by translating the yeast consensus metabolic network into a kinetic model. Despite crudely selected data, the model shows realistic control behaviour, a stable dynamic, and realistic response to perturbations in extracellular glucose concentrations. The paper concludes by outlining how new data can continuously be fed into the workflow and how iterative model building can assist in directing experiments.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Model
Publication ID: 24324546 Submission Date: 04 Jul 2013 10:28:54 UTC Last Modification Date: 04 Apr 2014 15:00:01 UTC Creation Date: 26 Nov 2013 12:56:29 UTC
Mathematical expressions
Reactions
1,3-beta-glucan synthase 1,4-alpha-glucan branching enzyme 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase 1-acyl-sn-gylcerol-3-phosphate acyltransferase
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (NADPH) 2-aceto-2-hydroxybutanoate synthase 2-aminoadipate transaminase
2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase 2-isopropylmalate hydratase 2-isopropylmalate synthase 2-methylcitrate dehydratase
2-oxo-4-methyl-3-carboxypentanoate decarboxylation 3',5'-bisphosphate nucleotidase 3,4-dihydroxy-2-butanone-4-phosphate synthase 3-dehydroquinate dehydratase
3-dehydroquinate synthase 3-dehydrosphinganine reductase 3-hydroxyacyl-CoA dehydrogenase (3-oxohexacosyl-CoA) 3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)
3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA) 3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA) 3-isopropylmalate dehydratase 3-isopropylmalate dehydrogenase
3-phosphoshikimate 1-carboxyvinyltransferase 5,10-methylenetetrahydrofolatereductase (NADPH) acetohydroxy acid isomeroreductase acetolactate synthase
acetyl-CoA C-acetyltransferase acetyl-Coa carboxylase acetyl-CoA hydrolase acetyl-CoA synthetase
acetylglutamate kinase acteylornithine transaminase adenosine kinase adenosylhomocysteinase
adenylate kinase adenylate kinase (GTP) adenylosuccinate lyase adenylosuccinate synthase
adenylsuccinate lyase adenylyl-sulfate kinase alanine glyoxylate aminotransferase alcohol dehydrogenase, reverse rxn (acetaldehyde -> ethanol)
aldehyde dehydrogenase (acetaldehyde, NADP) alpha,alpha-trehalose-phosphate synthase (UDP-forming) anthranilate phosphoribosyltransferase anthranilate synthase
argininosuccinate lyase argininosuccinate synthase asparagine synthase (glutamine-hydrolysing) aspartate carbamoyltransferase
aspartate kinase aspartate transaminase aspartate-semialdehyde dehydrogenase ATP phosphoribosyltransferase
ATP synthase ATPase, cytosolic bicarbonate formation C-14 sterol reductase
C-3 sterol dehydrogenase C-3 sterol dehydrogenase (4-methylzymosterol) C-3 sterol keto reductase (4-methylzymosterol) C-3 sterol keto reductase (zymosterol)
C-4 methyl sterol oxidase C-4 methyl sterol oxidase_2 C-4 methyl sterol oxidase_3 C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
C-8 sterol isomerase C-s24 sterol reductase carbamoyl-phosphate synthase (glutamine-hydrolysing) catalase
CDP-diacylglycerol synthase ceramide-1 hydroxylase (24C) ceramide-1 synthase (24C) cholestenol delta-isomerase, lumped reaction
chorismate mutase chorismate synthase cis-aconitate(3-) to isocitrate citrate synthase
citrate to cis-aconitate(3-) CTP synthase (NH3) cystathionine beta-synthase cystathionine g-lyase
cystathionine gamma-synthase cytidylate kinase (CMP) cytochrome P450 lanosterol 14-alpha-demethylase (NAD) D-arabinose 1-dehydrogenase (NAD)
D-arabinose 1-dehydrogenase (NADP) dCMP deaminase deoxyadenylate kinase deoxyguanylate kinase (dGMP:ATP)
diacylglycerol acyltransferase diacylglycerol pyrophosphate phosphatase dihydoorotic acid dehydrogenase dihydrofolate reductase
dihydroorotase dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) dihydroxyacetone kinase
dimethylallyltranstransferase dolichyl-phosphate D-mannosyltransferase dolichyl-phosphate-mannose--protein mannosyltransferase enolase
fatty acid synthase (n-C10:0) fatty acid synthase (n-C12:0) fatty acid synthase (n-C14:0) fatty acid synthase (n-C16:0)
fatty acid synthase (n-C18:0) fatty acid synthase (n-C24:0), lumped reaction fatty acyl-CoA synthase (n-C10:0CoA) fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
fatty-acid--CoA ligase (n-C24:0) fatty-acid--CoA ligase (octadecanoate) fatty-acid--CoA ligase (octanoate) fatty-acyl-CoA synthase (n-C12:0CoA)
fatty-acyl-CoA synthase (n-C14:0CoA) fatty-acyl-CoA synthase (n-C16:0CoA) fatty-acyl-CoA synthase (n-C18:0CoA) formate-tetrahydrofolate ligase
fructose-bisphosphate aldolase fumarase fumarate reductase geranyltranstransferase
glucokinase glucose-6-phosphate isomerase glucose-6-phosphate isomerase_2 glutamate 5-kinase
glutamate dehydrogenase (NADP) glutamate synthase (NADH2) glutamate-5-semialdehyde dehydrogenase glutamine phosphoribosyldiphosphate amidotransferase
glutamine synthetase glyceraldehyde-3-phosphate dehydrogenase glycerol dehydrogenase (NADP-dependent) glycerol-3-phosphatase
glycerol-3-phosphate dehydrogenase (fad) glycerol-3-phosphate dehydrogenase (NAD) glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase glycine cleavage system
glycine hydroxymethyltransferase glycogen (starch) synthase GMP synthase GTP cyclohydrolase II
guanylate kinase (GMP:ATP) guanylate kinase (GMP:dATP) hexokinase (D-glucose:ATP) histidinol dehydrogenase
histidinol-phosphatase histidinol-phosphate transaminase homoacontinate hydratase homocitrate synthase
homoisocitrate dehydrogenase homoserine dehydrogenase (NADH) homoserine kinase homoserine O-trans-acetylase
hydroxymethylglutaryl CoA reductase hydroxymethylglutaryl CoA synthase Imidazole-glycerol-3-phosphate synthase imidazoleglycerol-phosphate dehydratase
IMP cyclohydrolase IMP dehydrogenase indole-3-glycerol-phosphate synthase inorganic diphosphatase
inositolphosphotransferase IPC synthase isocitrate dehydrogenase (NADP) isocitrate lyase
isoleucine transaminase isopentenyl-diphosphate D-isomerase ketol-acid reductoisomerase (2-aceto-2-hydroxybutanoate) L-alanine transaminase
L-aminoadipate-semialdehyde dehydrogenase (NADH) L-glutamate 5-semialdehyde dehydratase L-hydroxyproline dehydrogenase (NADP) L-hydroxyproline reductase (NAD)
L-threonine deaminase lanosterol synthase leucine transaminase malate dehydrogenase
mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase methenyltetrahydrifikate cyclohydrolase methionine adenosyltransferase
methionine synthase methylenetetrahydrofolate dehydrogenase (NADP) mevalonate kinase (ctp) mevalonate pyrophoshate decarboxylase
microsomal beta-keto-reductase microsomal beta-keto-reductase_2 microsomal beta-keto-reductase_3 microsomal beta-keto-reductase_4
MIPC synthase myo-inositol 1-phosphatase myo-inositol-1-phosphate synthase N-acetyl-g-glutamyl-phosphate reductase
non-enzymatic reaction nucleoside-diphosphate kinase (ATP:CDP) nucleoside-diphosphate kinase (ATP:UDP) O-acetylhomoserine (thiol)-lyase
ornithine carbamoyltransferase ornithine transacetylase orotate phosphoribosyltransferase orotidine-5'-phosphate decarboxylase
phenylalanine transaminase phosphatidylethanolamine methyltransferase phosphatidylinositol synthase phosphatidylserine decarboxylase
phosphatidylserine synthase phosphoadenylyl-sulfate reductase (thioredoxin) phosphofructokinase phosphoglucomutase
phosphoglycerate kinase phosphoglycerate mutase phospholipid methyltransferase phospholipid methyltransferase_2
phosphomannomutase phosphomevalonate kinase phosphoribosyl-AMP cyclohydrolase phosphoribosyl-ATP pyrophosphatase
phosphoribosylaminoimidazole carboxylase phosphoribosylaminoimidazole synthase phosphoribosylaminoimidazolecarboxamide formyltransferase phosphoribosylaminoimidazolesuccinocarboxamide synthase
phosphoribosylanthranilate isomerase phosphoribosylformylglycinamidine synthase phosphoribosylglycinamide formyltransferase phosphoribosylglycinamide synthase
phosphoribosylpyrophosphate synthetase prephenate dehydratase prephenate dehydrogenase (NADP) pyrimidine phosphatase
pyrroline-5-carboxylate reductase pyruvate carboxylase pyruvate decarboxylase pyruvate dehydrogenase
pyruvate kinase riboflavin synthase riboflavin synthase_2 ribonucleoside-diphosphate reductase
ribonucleoside-diphosphate reductase (GDP) ribonucleoside-diphosphate reductase (UDP) ribonucleoside-triphosphate reductase (ATP) ribose-5-phosphate isomerase
ribulose 5-phosphate 3-epimerase S-adenosyl-methionine delta-24-sterol-c-methyltransferase saccharopine dehydrogenase (NAD, L-lysine forming) saccharopine dehydrogenase (NADP, L-glutamate forming)
serine C-palmitoyltransferase shikimate dehydrogenase shikimate kinase squalene epoxidase (NAD)
squalene synthase steryl ester hydrolase succinate-CoA ligase (ADP-forming) sulfate adenylyltransferase (ADP)
sulfite reductase (NADPH2) thioredoxin reductase (NADPH) threonine aldolase threonine synthase
thymidylate synthase transaldolase transketolase transketolase_2
trehalose-phosphatase triacylglycerol lipase triose-phosphate isomerase tryptophan synthase (indoleglycerol phosphate)
tyrosine transaminase UMP kinase uridylate kinase (dUMP) UTP-glucose-1-phosphate uridylyltransferase
valine transaminase ammonia transport CO2 transport ethanol transport
glucose transport O2 transport phosphate transport succinate transport
sulfate uniport isa acyl-CoA biomass production growth
lipid production      
Events
event_1      
Physical entities
Compartments Species
intracellular (1->3)-beta-D-glucan [intracellular] (2R,3R)-2,3-dihydroxy-3-methylpentanoate [intracellular] (2R,3S)-3-isopropylmalate(2-) [intracellular]
(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid [intracellular] (2S)-2-isopropyl-3-oxosuccinate(2-) [intracellular] (6R)-5,10-methenyltetrahydrofolic acid [intracellular]
(N(omega)-L-arginino)succinic acid [intracellular] (R)-2,3-dihydroxy-3-methylbutanoate [intracellular] (R)-5-diphosphomevalonic acid [intracellular]
(R)-5-phosphomevalonic acid [intracellular] (R)-mevalonate [intracellular] (S)-2,3-epoxysqualene [intracellular]
(S)-2-acetyl-2-hydroxybutanoate [intracellular] (S)-3-hydroxyhexacosanoyl-CoA [intracellular] (S)-3-hydroxypalmitoyl-CoA [intracellular]
(S)-3-hydroxytetradecanoyl-CoA [intracellular] (S)-3-methyl-2-oxopentanoate [intracellular] (S)-dihydroorotate [intracellular]
(S)-malate(2-) [intracellular] 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate [intracellular] 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide [intracellular]
1-(5-phosphoribosyl)-5'-AMP [intracellular] 1-acyl-sn-glycerol 3-phosphate [intracellular] 1-C-(indol-3-yl)glycerol 3-phosphate [intracellular]
1-phosphatidyl-1D-myo-inositol [intracellular] 1-pyrroline-3-hydroxy-5-carboxylic acid [intracellular] 1-pyrroline-5-carboxylate [intracellular]
10-formyltetrahydrofolic acid [intracellular] 14-demethyllanosterol [intracellular] 1D-myo-inositol 1-phosphate [intracellular]
2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine [intracellular] 2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone [intracellular] 2-acetamido-5-oxopentanoate [intracellular]
2-acetyllactic acid [intracellular] 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine [intracellular] 2-hydroxy-3-oxobutyl phosphate [intracellular]
2-isopropylmalate(2-) [intracellular] 2-isopropylmaleic acid [intracellular] 2-oxaloglutaric acid [intracellular]
2-oxoadipic acid [intracellular] 2-oxobutanoate [intracellular] 2-oxoglutarate [intracellular]
2-phospho-D-glyceric acid [intracellular] 2-trans,6-trans-farnesyl diphosphate [intracellular] 3'-phospho-5'-adenylyl sulfate [intracellular]
3-(4-hydroxyphenyl)pyruvate [intracellular] 3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate [intracellular] 3-dehydro-4-methylzymosterol [intracellular]
3-dehydroquinate [intracellular] 3-dehydroshikimate [intracellular] 3-dehydrosphinganine [intracellular]
3-hydroxy-3-methylglutaryl-CoA [intracellular] 3-hydroxyoctadecanoyl-CoA [intracellular] 3-methyl-2-oxobutanoate [intracellular]
3-oxohexacosanoyl-CoA [intracellular] 3-oxooctadecanoyl-CoA [intracellular] 3-oxopalmitoyl-CoA [intracellular]
3-oxotetradecanoyl-CoA [intracellular] 3-phospho-D-glyceric acid [intracellular] 3-phospho-D-glyceroyl dihydrogen phosphate [intracellular]
3-phosphoshikimic acid [intracellular] 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol [intracellular] 4-methyl-2-oxopentanoate [intracellular]
4-phospho-L-aspartate [intracellular] 4alpha-methylzymosterol [intracellular] 4beta-methylzymosterol-4alpha-carboxylic acid [intracellular]
5'-adenylyl sulfate [intracellular] 5'-xanthylic acid [intracellular] 5,10-methylenetetrahydrofolate(2-) [intracellular]
5,6,7,8-tetrahydrofolic acid [intracellular] 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular] 5-amino-1-(5-phospho-D-ribosyl)imidazole [intracellular]
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular] 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid [intracellular] 5-amino-6-(5-phosphoribitylamino)uracil [intracellular]
5-amino-6-(D-ribitylamino)uracil [intracellular] 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular] 5-methyltetrahydrofolate(2-) [intracellular]
5-O-(1-carboxyvinyl)-3-phosphoshikimic acid [intracellular] 5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular] 5-phospho-beta-D-ribosylamine [intracellular]
5-phosphoribosyl-ATP [intracellular] 6,7-dimethyl-8-(1-D-ribityl)lumazine [intracellular] 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid [intracellular]
acetaldehyde [intracellular] acetate [intracellular] acetoacetyl-CoA [intracellular]
acetyl-CoA [intracellular] acyl-CoA [intracellular] adenosine [intracellular]
adenosine 3',5'-bismonophosphate [intracellular] ADP [intracellular] aldehydo-D-glucose 6-phosphate [intracellular]
alpha,alpha-trehalose [intracellular] alpha,alpha-trehalose 6-phosphate [intracellular] alpha-D-ribose 5-phosphate [intracellular]
ammonium [intracellular] AMP [intracellular] amylose [intracellular]
anthranilate [intracellular] ATP [intracellular] beta-D-glucose 6-phosphate [intracellular]
bicarbonate [intracellular] biomass [intracellular] but-1-ene-1,2,4-tricarboxylic acid [intracellular]
carbamoyl phosphate [intracellular] carbon dioxide [intracellular] CDP [intracellular]
CDP-diacylglycerol [intracellular] chorismate(2-) [intracellular] cis-aconitate(3-) [intracellular]
citrate(3-) [intracellular] CMP [intracellular] coenzyme A [intracellular]
CTP [intracellular] D-arabinono-1,4-lactone [intracellular] D-arabinose [intracellular]
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate [intracellular] D-erythrose 4-phosphate(2-) [intracellular] D-fructose 1,6-bisphosphate [intracellular]
D-fructose 6-phosphate [intracellular] D-glucose [intracellular] D-glucose 1-phosphate [intracellular]
D-mannose 1-phosphate [intracellular] D-mannose 6-phosphate [intracellular] D-ribulose 5-phosphate [intracellular]
D-xylulose 5-phosphate [intracellular] dADP [intracellular] dAMP [intracellular]
dATP [intracellular] dCMP [intracellular] decanoate [intracellular]
decanoyl-CoA [intracellular] dGDP [intracellular] dGMP [intracellular]
diglyceride [intracellular] dihydrofolic acid [intracellular] diphosphate [intracellular]
dolichyl D-mannosyl phosphate [intracellular] dolichyl phosphate [intracellular] dTMP [intracellular]
dUDP [intracellular] dUMP [intracellular] episterol [intracellular]
ergosta-5,7,22,24(28)-tetraen-3beta-ol [intracellular] ergosterol [intracellular] ergosterol ester [intracellular]
ethanol [intracellular] FAD [intracellular] FADH2 [intracellular]
fatty acid [intracellular] fecosterol [intracellular] formate [intracellular]
fumarate(2-) [intracellular] GDP [intracellular] GDP-alpha-D-mannose [intracellular]
geranyl diphosphate [intracellular] glyceraldehyde 3-phosphate [intracellular] glycerol [intracellular]
glycerone [intracellular] glycerone phosphate [intracellular] glycine [intracellular]
glycogen [intracellular] glyoxylate [intracellular] GMP [intracellular]
GTP [intracellular] homocitrate(3-) [intracellular] homoisocitrate(3-) [intracellular]
hydrogen peroxide [intracellular] hydrogen sulfide [intracellular] IMP [intracellular]
inositol phosphomannosylinositol phosphoceramide [intracellular] inositol-P-ceramide B [intracellular] isocitrate(3-) [intracellular]
isopentenyl diphosphate [intracellular] keto-phenylpyruvate [intracellular] L-2-aminoadipate(2-) [intracellular]
L-alanine [intracellular] L-allysine [intracellular] L-arginine [intracellular]
L-asparagine [intracellular] L-aspartate [intracellular] L-aspartate 4-semialdehyde [intracellular]
L-citrulline [intracellular] L-cystathionine [intracellular] L-cysteine [intracellular]
L-gamma-glutamyl phosphate [intracellular] L-glutamate [intracellular] L-glutamic 5-semialdehyde [intracellular]
L-glutamine [intracellular] L-histidine [intracellular] L-histidinol [intracellular]
L-histidinol phosphate [intracellular] L-homocysteine [intracellular] L-homoserine [intracellular]
L-isoleucine [intracellular] L-leucine [intracellular] L-lysine [intracellular]
L-methionine [intracellular] L-phenylalanine [intracellular] L-proline [intracellular]
L-saccharopine [intracellular] L-serine [intracellular] L-threonine [intracellular]
L-tryptophan [intracellular] L-tyrosine [intracellular] L-valine [intracellular]
lanosterol [intracellular] laurate [intracellular] lauroyl-CoA [intracellular]
lignocerate [intracellular] lipid [intracellular] malonyl-CoA [intracellular]
mannan [intracellular] mannosylinositol phosphorylceramide [intracellular] myo-inositol [intracellular]
myristate [intracellular] myristoyl-CoA [intracellular] N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular]
N(2)-acetyl-L-ornithine [intracellular] N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular] N(6)-(1,2-dicarboxyethyl)-AMP [intracellular]
N-(24-hydroxytetracosanyl)sphinganine [intracellular] N-(5-phospho-beta-D-ribosyl)anthranilate [intracellular] N-acetyl-L-gamma-glutamyl phosphate [intracellular]
N-acetyl-L-glutamate(2-) [intracellular] N-carbamoyl-L-aspartate [intracellular] N-tetracosanylsphinganine [intracellular]
NAD(+) [intracellular] NADH [intracellular] NADP(+) [intracellular]
NADPH [intracellular] O-acetyl-L-homoserine [intracellular] O-phospho-L-homoserine [intracellular]
octanoate [intracellular] octanoyl-CoA [intracellular] ornithine [intracellular]
orotate [intracellular] orotidine 5'-(dihydrogen phosphate) [intracellular] oxaloacetate(2-) [intracellular]
oxygen [intracellular] palmitate [intracellular] palmitoyl-CoA [intracellular]
phosphate [intracellular] phosphatidate [intracellular] phosphatidyl-L-serine [intracellular]
phosphatidyl-N,N-dimethylethanolamine [intracellular] phosphatidyl-N-methylethanolamine [intracellular] phosphatidylcholine [intracellular]
phosphatidylethanolamine [intracellular] phosphoenolpyruvate [intracellular] prenyl diphosphate [intracellular]
prephenate(2-) [intracellular] pyruvate [intracellular] riboflavin [intracellular]
S-adenosyl-L-homocysteine [intracellular] S-adenosyl-L-methionine [intracellular] sedoheptulose 7-phosphate [intracellular]
shikimate [intracellular] sn-glycerol 3-phosphate [intracellular] sphinganine [intracellular]
squalene [intracellular] stearate [intracellular] stearoyl-CoA [intracellular]
succinate(2-) [intracellular] succinyl-CoA [intracellular] sulphate [intracellular]
sulphite [intracellular] tetracosanoyl-CoA [intracellular] trans-4-hydroxy-L-proline [intracellular]
triglyceride [intracellular] UDP [intracellular] UDP-D-glucose [intracellular]
UMP [intracellular] UTP [intracellular] zymosterol [intracellular]
zymosterol intermediate 1a [intracellular] zymosterol intermediate 1b [intracellular] zymosterol intermediate 1c [intracellular]
zymosterol intermediate 2 [intracellular] thioredoxin disulfide [intracellular] thioredoxin dithiol [intracellular]
H+ [intracellular] water [intracellular] glucose [extracellular]
     
extracellular ammonium [extracellular] biomass [extracellular] carbon dioxide [extracellular]
D-glucose [extracellular] ethanol [extracellular] H+ [extracellular]
oxygen [extracellular] phosphate [extracellular] succinate(2-) [extracellular]
sulphate [extracellular]    
Reactions (285)
 
 1,3-beta-glucan synthase [UDP-D-glucose [intracellular]] ↔ [(1->3)-beta-D-glucan [intracellular]] + [H+ [intracellular]] + [UDP [intracellular]];   {(1->3)-beta-D-glucan [intracellular]} , {H+ [intracellular]} , {UDP [intracellular]} , {UDP-D-glucose [intracellular]}
 
 1,4-alpha-glucan branching enzyme [amylose [intracellular]] ↔ [glycogen [intracellular]] + [water [intracellular]];   {amylose [intracellular]} , {glycogen [intracellular]} , {water [intracellular]}
 
 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase [1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide [intracellular]] ↔ [5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]];   {1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide [intracellular]} , {5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]}
 
 1-acyl-sn-gylcerol-3-phosphate acyltransferase [1-acyl-sn-glycerol 3-phosphate [intracellular]] + [acyl-CoA [intracellular]] ↔ [coenzyme A [intracellular]] + 4.0 × [H+ [intracellular]] + [phosphatidate [intracellular]];   {1-acyl-sn-glycerol 3-phosphate [intracellular]} , {acyl-CoA [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {phosphatidate [intracellular]}
 
 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase [2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone [intracellular]] + [H+ [intracellular]] + [water [intracellular]] ↔ [5-amino-6-(5-phosphoribitylamino)uracil [intracellular]] + [ammonium [intracellular]];   {2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone [intracellular]} , {5-amino-6-(5-phosphoribitylamino)uracil [intracellular]} , {ammonium [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (NADPH) [2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone [intracellular]] + [NADP(+) [intracellular]];   {2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine [intracellular]} , {2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 2-aceto-2-hydroxybutanoate synthase [2-oxobutanoate [intracellular]] + [H+ [intracellular]] + [pyruvate [intracellular]] ↔ [(S)-2-acetyl-2-hydroxybutanoate [intracellular]] + [carbon dioxide [intracellular]];   {(S)-2-acetyl-2-hydroxybutanoate [intracellular]} , {2-oxobutanoate [intracellular]} , {carbon dioxide [intracellular]} , {H+ [intracellular]} , {pyruvate [intracellular]}
 
 2-aminoadipate transaminase [2-oxoadipic acid [intracellular]] + [L-glutamate [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [L-2-aminoadipate(2-) [intracellular]];   {2-oxoadipic acid [intracellular]} , {2-oxoglutarate [intracellular]} , {L-2-aminoadipate(2-) [intracellular]} , {L-glutamate [intracellular]}
 
 2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase [D-erythrose 4-phosphate(2-) [intracellular]] + [phosphoenolpyruvate [intracellular]] + [water [intracellular]] ↔ [7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid [intracellular]] + [phosphate [intracellular]];   {7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid [intracellular]} , {D-erythrose 4-phosphate(2-) [intracellular]} , {phosphate [intracellular]} , {phosphoenolpyruvate [intracellular]} , {water [intracellular]}
 
 2-isopropylmalate hydratase [2-isopropylmalate(2-) [intracellular]] ↔ [2-isopropylmaleic acid [intracellular]] + [water [intracellular]];   {2-isopropylmalate(2-) [intracellular]} , {2-isopropylmaleic acid [intracellular]} , {water [intracellular]}
 
 2-isopropylmalate synthase [3-methyl-2-oxobutanoate [intracellular]] + [acetyl-CoA [intracellular]] + [water [intracellular]] ↔ [2-isopropylmalate(2-) [intracellular]] + [coenzyme A [intracellular]] + [H+ [intracellular]];   {2-isopropylmalate(2-) [intracellular]} , {3-methyl-2-oxobutanoate [intracellular]} , {acetyl-CoA [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 2-methylcitrate dehydratase [homocitrate(3-) [intracellular]] ↔ [but-1-ene-1,2,4-tricarboxylic acid [intracellular]] + [water [intracellular]];   {but-1-ene-1,2,4-tricarboxylic acid [intracellular]} , {homocitrate(3-) [intracellular]} , {water [intracellular]}
 
 2-oxo-4-methyl-3-carboxypentanoate decarboxylation [(2S)-2-isopropyl-3-oxosuccinate(2-) [intracellular]] + [H+ [intracellular]] ↔ [4-methyl-2-oxopentanoate [intracellular]] + [carbon dioxide [intracellular]];   {(2S)-2-isopropyl-3-oxosuccinate(2-) [intracellular]} , {4-methyl-2-oxopentanoate [intracellular]} , {carbon dioxide [intracellular]} , {H+ [intracellular]}
 
 3',5'-bisphosphate nucleotidase [adenosine 3',5'-bismonophosphate [intracellular]] + [water [intracellular]] ↔ [AMP [intracellular]] + [phosphate [intracellular]];   {adenosine 3',5'-bismonophosphate [intracellular]} , {AMP [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 3,4-dihydroxy-2-butanone-4-phosphate synthase [D-ribulose 5-phosphate [intracellular]] ↔ [2-hydroxy-3-oxobutyl phosphate [intracellular]] + [formate [intracellular]] + [H+ [intracellular]];   {2-hydroxy-3-oxobutyl phosphate [intracellular]} , {D-ribulose 5-phosphate [intracellular]} , {formate [intracellular]} , {H+ [intracellular]}
 
 3-dehydroquinate dehydratase [3-dehydroquinate [intracellular]] ↔ [3-dehydroshikimate [intracellular]] + [water [intracellular]];   {3-dehydroquinate [intracellular]} , {3-dehydroshikimate [intracellular]} , {water [intracellular]}
 
 3-dehydroquinate synthase [7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid [intracellular]] ↔ [3-dehydroquinate [intracellular]] + [phosphate [intracellular]];   {3-dehydroquinate [intracellular]} , {7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid [intracellular]} , {phosphate [intracellular]}
 
 3-dehydrosphinganine reductase [3-dehydrosphinganine [intracellular]] + 2.0 × [H+ [intracellular]] + [NADPH [intracellular]] ↔ [NADP(+) [intracellular]] + [sphinganine [intracellular]];   {3-dehydrosphinganine [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {sphinganine [intracellular]}
 
 3-hydroxyacyl-CoA dehydrogenase (3-oxohexacosyl-CoA) [3-oxohexacosanoyl-CoA [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]] ↔ [(S)-3-hydroxyhexacosanoyl-CoA [intracellular]] + [NAD(+) [intracellular]];   {(S)-3-hydroxyhexacosanoyl-CoA [intracellular]} , {3-oxohexacosanoyl-CoA [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA) [3-oxopalmitoyl-CoA [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]] ↔ [(S)-3-hydroxypalmitoyl-CoA [intracellular]] + [NAD(+) [intracellular]];   {(S)-3-hydroxypalmitoyl-CoA [intracellular]} , {3-oxopalmitoyl-CoA [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA) [3-oxooctadecanoyl-CoA [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]] ↔ [3-hydroxyoctadecanoyl-CoA [intracellular]] + [NAD(+) [intracellular]];   {3-hydroxyoctadecanoyl-CoA [intracellular]} , {3-oxooctadecanoyl-CoA [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA) [3-oxotetradecanoyl-CoA [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]] ↔ [(S)-3-hydroxytetradecanoyl-CoA [intracellular]] + [NAD(+) [intracellular]];   {(S)-3-hydroxytetradecanoyl-CoA [intracellular]} , {3-oxotetradecanoyl-CoA [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 3-isopropylmalate dehydratase [2-isopropylmaleic acid [intracellular]] + [water [intracellular]] ↔ [(2R,3S)-3-isopropylmalate(2-) [intracellular]];   {(2R,3S)-3-isopropylmalate(2-) [intracellular]} , {2-isopropylmaleic acid [intracellular]} , {water [intracellular]}
 
 3-isopropylmalate dehydrogenase [(2R,3S)-3-isopropylmalate(2-) [intracellular]] + [NAD(+) [intracellular]] ↔ [(2S)-2-isopropyl-3-oxosuccinate(2-) [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]];   {(2R,3S)-3-isopropylmalate(2-) [intracellular]} , {(2S)-2-isopropyl-3-oxosuccinate(2-) [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 3-phosphoshikimate 1-carboxyvinyltransferase [3-phosphoshikimic acid [intracellular]] + [phosphoenolpyruvate [intracellular]] ↔ [5-O-(1-carboxyvinyl)-3-phosphoshikimic acid [intracellular]] + [phosphate [intracellular]];   {3-phosphoshikimic acid [intracellular]} , {5-O-(1-carboxyvinyl)-3-phosphoshikimic acid [intracellular]} , {phosphate [intracellular]} , {phosphoenolpyruvate [intracellular]}
 
 5,10-methylenetetrahydrofolatereductase (NADPH) [5,10-methylenetetrahydrofolate(2-) [intracellular]] + 2.0 × [H+ [intracellular]] + [NADPH [intracellular]] ↔ [5-methyltetrahydrofolate(2-) [intracellular]] + [NADP(+) [intracellular]];   {5,10-methylenetetrahydrofolate(2-) [intracellular]} , {5-methyltetrahydrofolate(2-) [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 acetohydroxy acid isomeroreductase [2-acetyllactic acid [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [(R)-2,3-dihydroxy-3-methylbutanoate [intracellular]] + [NADP(+) [intracellular]];   {(R)-2,3-dihydroxy-3-methylbutanoate [intracellular]} , {2-acetyllactic acid [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 acetolactate synthase [H+ [intracellular]] + 2.0 × [pyruvate [intracellular]] ↔ [2-acetyllactic acid [intracellular]] + [carbon dioxide [intracellular]];   {2-acetyllactic acid [intracellular]} , {carbon dioxide [intracellular]} , {H+ [intracellular]} , {pyruvate [intracellular]}
 
 acetyl-CoA C-acetyltransferase 2.0 × [acetyl-CoA [intracellular]] ↔ [acetoacetyl-CoA [intracellular]] + [coenzyme A [intracellular]];   {acetoacetyl-CoA [intracellular]} , {acetyl-CoA [intracellular]} , {coenzyme A [intracellular]}
 
 acetyl-Coa carboxylase [acetyl-CoA [intracellular]] + [ATP [intracellular]] + [bicarbonate [intracellular]] ↔ [ADP [intracellular]] + [H+ [intracellular]] + [malonyl-CoA [intracellular]] + [phosphate [intracellular]];   {acetyl-CoA [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {bicarbonate [intracellular]} , {H+ [intracellular]} , {malonyl-CoA [intracellular]} , {phosphate [intracellular]}
 
 acetyl-CoA hydrolase [acetate [intracellular]] + [coenzyme A [intracellular]] + [H+ [intracellular]] ↔ [acetyl-CoA [intracellular]] + [water [intracellular]];   {acetate [intracellular]} , {acetyl-CoA [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 acetyl-CoA synthetase [acetyl-CoA [intracellular]] + [AMP [intracellular]] + [diphosphate [intracellular]] ↔ [acetate [intracellular]] + [ATP [intracellular]] + [coenzyme A [intracellular]];   {acetate [intracellular]} , {acetyl-CoA [intracellular]} , {AMP [intracellular]} , {ATP [intracellular]} , {coenzyme A [intracellular]} , {diphosphate [intracellular]}
 
 acetylglutamate kinase [ATP [intracellular]] + [N-acetyl-L-glutamate(2-) [intracellular]] ↔ [ADP [intracellular]] + [N-acetyl-L-gamma-glutamyl phosphate [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {N-acetyl-L-gamma-glutamyl phosphate [intracellular]} , {N-acetyl-L-glutamate(2-) [intracellular]}
 
 acteylornithine transaminase [2-acetamido-5-oxopentanoate [intracellular]] + [L-glutamate [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [N(2)-acetyl-L-ornithine [intracellular]];   {2-acetamido-5-oxopentanoate [intracellular]} , {2-oxoglutarate [intracellular]} , {L-glutamate [intracellular]} , {N(2)-acetyl-L-ornithine [intracellular]}
 
 adenosine kinase [adenosine [intracellular]] + [ATP [intracellular]] ↔ [ADP [intracellular]] + [AMP [intracellular]] + [H+ [intracellular]];   {adenosine [intracellular]} , {ADP [intracellular]} , {AMP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]}
 
 adenosylhomocysteinase [S-adenosyl-L-homocysteine [intracellular]] + [water [intracellular]] ↔ [adenosine [intracellular]] + [L-homocysteine [intracellular]];   {adenosine [intracellular]} , {L-homocysteine [intracellular]} , {S-adenosyl-L-homocysteine [intracellular]} , {water [intracellular]}
 
 adenylate kinase 2.0 × [ADP [intracellular]] ↔ [AMP [intracellular]] + [ATP [intracellular]];   {ADP [intracellular]} , {AMP [intracellular]} , {ATP [intracellular]}
 
 adenylate kinase (GTP) [ADP [intracellular]] + [GDP [intracellular]] ↔ [AMP [intracellular]] + [GTP [intracellular]];   {ADP [intracellular]} , {AMP [intracellular]} , {GDP [intracellular]} , {GTP [intracellular]}
 
 adenylosuccinate lyase [(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid [intracellular]] ↔ [5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]] + [fumarate(2-) [intracellular]];   {(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid [intracellular]} , {5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]} , {fumarate(2-) [intracellular]}
 
 adenylosuccinate synthase [GTP [intracellular]] + [IMP [intracellular]] + [L-aspartate [intracellular]] ↔ [GDP [intracellular]] + 2.0 × [H+ [intracellular]] + [N(6)-(1,2-dicarboxyethyl)-AMP [intracellular]] + [phosphate [intracellular]];   {GDP [intracellular]} , {GTP [intracellular]} , {H+ [intracellular]} , {IMP [intracellular]} , {L-aspartate [intracellular]} , {N(6)-(1,2-dicarboxyethyl)-AMP [intracellular]} , {phosphate [intracellular]}
 
 adenylsuccinate lyase [N(6)-(1,2-dicarboxyethyl)-AMP [intracellular]] ↔ [AMP [intracellular]] + [fumarate(2-) [intracellular]];   {AMP [intracellular]} , {fumarate(2-) [intracellular]} , {N(6)-(1,2-dicarboxyethyl)-AMP [intracellular]}
 
 adenylyl-sulfate kinase [5'-adenylyl sulfate [intracellular]] + [ATP [intracellular]] ↔ [3'-phospho-5'-adenylyl sulfate [intracellular]] + [ADP [intracellular]] + [H+ [intracellular]];   {3'-phospho-5'-adenylyl sulfate [intracellular]} , {5'-adenylyl sulfate [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]}
 
 alanine glyoxylate aminotransferase [glyoxylate [intracellular]] + [L-alanine [intracellular]] ↔ [glycine [intracellular]] + [pyruvate [intracellular]];   {glycine [intracellular]} , {glyoxylate [intracellular]} , {L-alanine [intracellular]} , {pyruvate [intracellular]}
 
 alcohol dehydrogenase, reverse rxn (acetaldehyde -> ethanol) [acetaldehyde [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]] ↔ [ethanol [intracellular]] + [NAD(+) [intracellular]];   {acetaldehyde [intracellular]} , {ethanol [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 aldehyde dehydrogenase (acetaldehyde, NADP) [acetaldehyde [intracellular]] + [NADP(+) [intracellular]] + [water [intracellular]] ↔ [acetate [intracellular]] + 2.0 × [H+ [intracellular]] + [NADPH [intracellular]];   {acetaldehyde [intracellular]} , {acetate [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {water [intracellular]}
 
 alpha,alpha-trehalose-phosphate synthase (UDP-forming) [aldehydo-D-glucose 6-phosphate [intracellular]] + [UDP-D-glucose [intracellular]] ↔ [alpha,alpha-trehalose 6-phosphate [intracellular]] + [H+ [intracellular]] + [UDP [intracellular]];   {UDP-D-glucose [intracellular]} , {aldehydo-D-glucose 6-phosphate [intracellular]} , {UDP-D-glucose [intracellular]} , {alpha,alpha-trehalose 6-phosphate [intracellular]} , {H+ [intracellular]} , {UDP [intracellular]}
 
 anthranilate phosphoribosyltransferase [5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]] + [anthranilate [intracellular]] ↔ [diphosphate [intracellular]] + [N-(5-phospho-beta-D-ribosyl)anthranilate [intracellular]];   {5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]} , {anthranilate [intracellular]} , {diphosphate [intracellular]} , {N-(5-phospho-beta-D-ribosyl)anthranilate [intracellular]}
 
 anthranilate synthase [chorismate(2-) [intracellular]] + [L-glutamine [intracellular]] ↔ [anthranilate [intracellular]] + [H+ [intracellular]] + [L-glutamate [intracellular]] + [pyruvate [intracellular]];   {anthranilate [intracellular]} , {chorismate(2-) [intracellular]} , {H+ [intracellular]} , {L-glutamate [intracellular]} , {L-glutamine [intracellular]} , {pyruvate [intracellular]}
 
 argininosuccinate lyase [(N(omega)-L-arginino)succinic acid [intracellular]] ↔ [fumarate(2-) [intracellular]] + [L-arginine [intracellular]];   {(N(omega)-L-arginino)succinic acid [intracellular]} , {fumarate(2-) [intracellular]} , {L-arginine [intracellular]}
 
 argininosuccinate synthase [ATP [intracellular]] + [L-aspartate [intracellular]] + [L-citrulline [intracellular]] ↔ [(N(omega)-L-arginino)succinic acid [intracellular]] + [AMP [intracellular]] + [diphosphate [intracellular]] + [H+ [intracellular]];   {(N(omega)-L-arginino)succinic acid [intracellular]} , {AMP [intracellular]} , {ATP [intracellular]} , {diphosphate [intracellular]} , {H+ [intracellular]} , {L-aspartate [intracellular]} , {L-citrulline [intracellular]}
 
 asparagine synthase (glutamine-hydrolysing) [ATP [intracellular]] + [L-aspartate [intracellular]] + [L-glutamine [intracellular]] + [water [intracellular]] ↔ [AMP [intracellular]] + [diphosphate [intracellular]] + [H+ [intracellular]] + [L-asparagine [intracellular]] + [L-glutamate [intracellular]];   {AMP [intracellular]} , {ATP [intracellular]} , {diphosphate [intracellular]} , {H+ [intracellular]} , {L-asparagine [intracellular]} , {L-aspartate [intracellular]} , {L-glutamate [intracellular]} , {L-glutamine [intracellular]} , {water [intracellular]}
 
 aspartate carbamoyltransferase [carbamoyl phosphate [intracellular]] + [L-aspartate [intracellular]] ↔ [H+ [intracellular]] + [N-carbamoyl-L-aspartate [intracellular]] + [phosphate [intracellular]];   {carbamoyl phosphate [intracellular]} , {H+ [intracellular]} , {L-aspartate [intracellular]} , {N-carbamoyl-L-aspartate [intracellular]} , {phosphate [intracellular]}
 
 aspartate kinase [ATP [intracellular]] + [L-aspartate [intracellular]] ↔ [4-phospho-L-aspartate [intracellular]] + [ADP [intracellular]];   {4-phospho-L-aspartate [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {L-aspartate [intracellular]}
 
 aspartate transaminase [L-glutamate [intracellular]] + [oxaloacetate(2-) [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [L-aspartate [intracellular]];   {2-oxoglutarate [intracellular]} , {L-aspartate [intracellular]} , {L-glutamate [intracellular]} , {oxaloacetate(2-) [intracellular]}
 
 aspartate-semialdehyde dehydrogenase [4-phospho-L-aspartate [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [L-aspartate 4-semialdehyde [intracellular]] + [NADP(+) [intracellular]] + [phosphate [intracellular]];   {4-phospho-L-aspartate [intracellular]} , {H+ [intracellular]} , {L-aspartate 4-semialdehyde [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {phosphate [intracellular]}
 
 ATP phosphoribosyltransferase [5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]] + [ATP [intracellular]] ↔ [5-phosphoribosyl-ATP [intracellular]] + [diphosphate [intracellular]];   {5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]} , {5-phosphoribosyl-ATP [intracellular]} , {ATP [intracellular]} , {diphosphate [intracellular]}
 
 ATP synthase [ADP [intracellular]] + 3.0 × [H+ [intracellular]] + [phosphate [intracellular]] ↔ [ATP [intracellular]] + 2.0 × [H+ [intracellular]] + [water [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 ATPase, cytosolic [ATP [intracellular]] + [water [intracellular]] ↔ [ADP [intracellular]] + [H+ [extracellular]] + [phosphate [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {H+ [extracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 bicarbonate formation [carbon dioxide [intracellular]] + [water [intracellular]] ↔ [bicarbonate [intracellular]] + [H+ [intracellular]];   {bicarbonate [intracellular]} , {carbon dioxide [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 C-14 sterol reductase [4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [14-demethyllanosterol [intracellular]] + [NADP(+) [intracellular]];   {14-demethyllanosterol [intracellular]} , {4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 C-3 sterol dehydrogenase [NADP(+) [intracellular]] + [zymosterol intermediate 1c [intracellular]] ↔ [carbon dioxide [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] + [zymosterol intermediate 2 [intracellular]];   {carbon dioxide [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {zymosterol intermediate 1c [intracellular]} , {zymosterol intermediate 2 [intracellular]}
 
 C-3 sterol dehydrogenase (4-methylzymosterol) [4beta-methylzymosterol-4alpha-carboxylic acid [intracellular]] + [NAD(+) [intracellular]] ↔ [3-dehydro-4-methylzymosterol [intracellular]] + [carbon dioxide [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]];   {3-dehydro-4-methylzymosterol [intracellular]} , {4beta-methylzymosterol-4alpha-carboxylic acid [intracellular]} , {carbon dioxide [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 C-3 sterol keto reductase (4-methylzymosterol) [3-dehydro-4-methylzymosterol [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [4alpha-methylzymosterol [intracellular]] + [NADP(+) [intracellular]];   {3-dehydro-4-methylzymosterol [intracellular]} , {4alpha-methylzymosterol [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 C-3 sterol keto reductase (zymosterol) [H+ [intracellular]] + [NADPH [intracellular]] + [zymosterol intermediate 2 [intracellular]] ↔ [NADP(+) [intracellular]] + [zymosterol [intracellular]];   {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {zymosterol [intracellular]} , {zymosterol intermediate 2 [intracellular]}
 
 C-4 methyl sterol oxidase [4alpha-methylzymosterol [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] + [oxygen [intracellular]] ↔ [NADP(+) [intracellular]] + [water [intracellular]] + [zymosterol intermediate 1a [intracellular]];   {4alpha-methylzymosterol [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {oxygen [intracellular]} , {water [intracellular]} , {zymosterol intermediate 1a [intracellular]}
 
 C-4 methyl sterol oxidase_2 [H+ [intracellular]] + [NADPH [intracellular]] + [oxygen [intracellular]] + [zymosterol intermediate 1a [intracellular]] ↔ [NADP(+) [intracellular]] + 2.0 × [water [intracellular]] + [zymosterol intermediate 1b [intracellular]];   {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {oxygen [intracellular]} , {water [intracellular]} , {zymosterol intermediate 1a [intracellular]} , {zymosterol intermediate 1b [intracellular]}
 
 C-4 methyl sterol oxidase_3 [H+ [intracellular]] + [NADPH [intracellular]] + [oxygen [intracellular]] + [zymosterol intermediate 1b [intracellular]] ↔ [NADP(+) [intracellular]] + [water [intracellular]] + [zymosterol intermediate 1c [intracellular]];   {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {oxygen [intracellular]} , {water [intracellular]} , {zymosterol intermediate 1b [intracellular]} , {zymosterol intermediate 1c [intracellular]}
 
 C-4 sterol methyl oxidase (4,4-dimethylzymosterol) [14-demethyllanosterol [intracellular]] + 3.0 × [H+ [intracellular]] + 3.0 × [NADPH [intracellular]] + 3.0 × [oxygen [intracellular]] ↔ [4beta-methylzymosterol-4alpha-carboxylic acid [intracellular]] + 3.0 × [NADP(+) [intracellular]] + 4.0 × [water [intracellular]];   {14-demethyllanosterol [intracellular]} , {4beta-methylzymosterol-4alpha-carboxylic acid [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {oxygen [intracellular]} , {water [intracellular]}
 
 C-8 sterol isomerase [fecosterol [intracellular]] ↔ [episterol [intracellular]];   {episterol [intracellular]} , {fecosterol [intracellular]}
 
 C-s24 sterol reductase [ergosta-5,7,22,24(28)-tetraen-3beta-ol [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [ergosterol [intracellular]] + [NADP(+) [intracellular]];   {ergosta-5,7,22,24(28)-tetraen-3beta-ol [intracellular]} , {ergosterol [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 carbamoyl-phosphate synthase (glutamine-hydrolysing) 2.0 × [ATP [intracellular]] + [bicarbonate [intracellular]] + [L-glutamine [intracellular]] + [water [intracellular]] ↔ 2.0 × [ADP [intracellular]] + [carbamoyl phosphate [intracellular]] + 2.0 × [H+ [intracellular]] + [L-glutamate [intracellular]] + [phosphate [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {bicarbonate [intracellular]} , {carbamoyl phosphate [intracellular]} , {H+ [intracellular]} , {L-glutamate [intracellular]} , {L-glutamine [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 catalase 2.0 × [hydrogen peroxide [intracellular]] ↔ [oxygen [intracellular]] + 2.0 × [water [intracellular]];   {hydrogen peroxide [intracellular]} , {oxygen [intracellular]} , {water [intracellular]}
 
 CDP-diacylglycerol synthase [CTP [intracellular]] + [H+ [intracellular]] + [phosphatidate [intracellular]] ↔ [CDP-diacylglycerol [intracellular]] + [diphosphate [intracellular]];   {CDP-diacylglycerol [intracellular]} , {CTP [intracellular]} , {diphosphate [intracellular]} , {H+ [intracellular]} , {phosphatidate [intracellular]}
 
 ceramide-1 hydroxylase (24C) [H+ [intracellular]] + [N-tetracosanylsphinganine [intracellular]] + [NADPH [intracellular]] + [oxygen [intracellular]] ↔ [N-(24-hydroxytetracosanyl)sphinganine [intracellular]] + [NADP(+) [intracellular]] + [water [intracellular]];   {H+ [intracellular]} , {N-(24-hydroxytetracosanyl)sphinganine [intracellular]} , {N-tetracosanylsphinganine [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {oxygen [intracellular]} , {water [intracellular]}
 
 ceramide-1 synthase (24C) [sphinganine [intracellular]] + [tetracosanoyl-CoA [intracellular]] ↔ [coenzyme A [intracellular]] + [H+ [intracellular]] + [N-tetracosanylsphinganine [intracellular]];   {coenzyme A [intracellular]} , {H+ [intracellular]} , {N-tetracosanylsphinganine [intracellular]} , {sphinganine [intracellular]} , {tetracosanoyl-CoA [intracellular]}
 
 cholestenol delta-isomerase, lumped reaction [oxygen [intracellular]] + [S-adenosyl-L-methionine [intracellular]] + [zymosterol [intracellular]] ↔ [ergosta-5,7,22,24(28)-tetraen-3beta-ol [intracellular]] + [H+ [intracellular]] + [S-adenosyl-L-homocysteine [intracellular]] + 2.0 × [water [intracellular]];   {ergosta-5,7,22,24(28)-tetraen-3beta-ol [intracellular]} , {H+ [intracellular]} , {oxygen [intracellular]} , {S-adenosyl-L-homocysteine [intracellular]} , {S-adenosyl-L-methionine [intracellular]} , {water [intracellular]} , {zymosterol [intracellular]}
 
 chorismate mutase [chorismate(2-) [intracellular]] ↔ [prephenate(2-) [intracellular]];   {chorismate(2-) [intracellular]} , {prephenate(2-) [intracellular]}
 
 chorismate synthase [5-O-(1-carboxyvinyl)-3-phosphoshikimic acid [intracellular]] ↔ [chorismate(2-) [intracellular]] + [phosphate [intracellular]];   {5-O-(1-carboxyvinyl)-3-phosphoshikimic acid [intracellular]} , {chorismate(2-) [intracellular]} , {phosphate [intracellular]}
 
 cis-aconitate(3-) to isocitrate [cis-aconitate(3-) [intracellular]] + [water [intracellular]] ↔ [isocitrate(3-) [intracellular]];   {cis-aconitate(3-) [intracellular]} , {isocitrate(3-) [intracellular]} , {water [intracellular]}
 
 citrate synthase [acetyl-CoA [intracellular]] + [oxaloacetate(2-) [intracellular]] + [water [intracellular]] ↔ [citrate(3-) [intracellular]] + [coenzyme A [intracellular]] + [H+ [intracellular]];   {acetyl-CoA [intracellular]} , {citrate(3-) [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {oxaloacetate(2-) [intracellular]} , {water [intracellular]}
 
 citrate to cis-aconitate(3-) [citrate(3-) [intracellular]] ↔ [cis-aconitate(3-) [intracellular]] + [water [intracellular]];   {cis-aconitate(3-) [intracellular]} , {citrate(3-) [intracellular]} , {water [intracellular]}
 
 CTP synthase (NH3) [ammonium [intracellular]] + [ATP [intracellular]] + [UTP [intracellular]] ↔ [ADP [intracellular]] + [CTP [intracellular]] + 2.0 × [H+ [intracellular]] + [phosphate [intracellular]];   {ADP [intracellular]} , {ammonium [intracellular]} , {ATP [intracellular]} , {CTP [intracellular]} , {H+ [intracellular]} , {phosphate [intracellular]} , {UTP [intracellular]}
 
 cystathionine beta-synthase [L-homocysteine [intracellular]] + [L-serine [intracellular]] ↔ [L-cystathionine [intracellular]] + [water [intracellular]];   {L-cystathionine [intracellular]} , {L-homocysteine [intracellular]} , {L-serine [intracellular]} , {water [intracellular]}
 
 cystathionine g-lyase [L-cystathionine [intracellular]] + [water [intracellular]] ↔ [2-oxobutanoate [intracellular]] + [ammonium [intracellular]] + [L-cysteine [intracellular]];   {2-oxobutanoate [intracellular]} , {ammonium [intracellular]} , {L-cystathionine [intracellular]} , {L-cysteine [intracellular]} , {water [intracellular]}
 
 cystathionine gamma-synthase [L-cysteine [intracellular]] + [O-acetyl-L-homoserine [intracellular]] ↔ [acetate [intracellular]] + [H+ [intracellular]] + [L-cystathionine [intracellular]];   {acetate [intracellular]} , {H+ [intracellular]} , {L-cystathionine [intracellular]} , {L-cysteine [intracellular]} , {O-acetyl-L-homoserine [intracellular]}
 
 cytidylate kinase (CMP) [ADP [intracellular]] + [CDP [intracellular]] ↔ [ATP [intracellular]] + [CMP [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {CDP [intracellular]} , {CMP [intracellular]}
 
 cytochrome P450 lanosterol 14-alpha-demethylase (NAD) 2.0 × [H+ [intracellular]] + [lanosterol [intracellular]] + 3.0 × [NADH [intracellular]] + 3.0 × [oxygen [intracellular]] ↔ [4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol [intracellular]] + [formate [intracellular]] + 3.0 × [NAD(+) [intracellular]] + 4.0 × [water [intracellular]];   {4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol [intracellular]} , {formate [intracellular]} , {H+ [intracellular]} , {lanosterol [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {oxygen [intracellular]} , {water [intracellular]}
 
 D-arabinose 1-dehydrogenase (NAD) [D-arabinono-1,4-lactone [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]] ↔ [D-arabinose [intracellular]] + [NAD(+) [intracellular]];   {D-arabinono-1,4-lactone [intracellular]} , {D-arabinose [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 D-arabinose 1-dehydrogenase (NADP) [D-arabinose [intracellular]] + [NADP(+) [intracellular]] ↔ [D-arabinono-1,4-lactone [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]];   {D-arabinono-1,4-lactone [intracellular]} , {D-arabinose [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 dCMP deaminase [ammonium [intracellular]] + [dUMP [intracellular]] ↔ [dCMP [intracellular]] + [H+ [intracellular]] + [water [intracellular]];   {ammonium [intracellular]} , {dCMP [intracellular]} , {dUMP [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 deoxyadenylate kinase [ADP [intracellular]] + [dADP [intracellular]] ↔ [ATP [intracellular]] + [dAMP [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {dADP [intracellular]} , {dAMP [intracellular]}
 
 deoxyguanylate kinase (dGMP:ATP) [ADP [intracellular]] + [dGDP [intracellular]] ↔ [ATP [intracellular]] + [dGMP [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {dGDP [intracellular]} , {dGMP [intracellular]}
 
 diacylglycerol acyltransferase [acyl-CoA [intracellular]] + [diglyceride [intracellular]] ↔ [coenzyme A [intracellular]] + 4.0 × [H+ [intracellular]] + [triglyceride [intracellular]];   {acyl-CoA [intracellular]} , {coenzyme A [intracellular]} , {diglyceride [intracellular]} , {H+ [intracellular]} , {triglyceride [intracellular]}
 
 diacylglycerol pyrophosphate phosphatase [phosphatidate [intracellular]] + [water [intracellular]] ↔ [diglyceride [intracellular]] + 2.0 × [H+ [intracellular]] + [phosphate [intracellular]];   {diglyceride [intracellular]} , {H+ [intracellular]} , {phosphate [intracellular]} , {phosphatidate [intracellular]} , {water [intracellular]}
 
 dihydoorotic acid dehydrogenase [(S)-dihydroorotate [intracellular]] + [oxygen [intracellular]] ↔ [hydrogen peroxide [intracellular]] + [orotate [intracellular]];   {(S)-dihydroorotate [intracellular]} , {hydrogen peroxide [intracellular]} , {orotate [intracellular]} , {oxygen [intracellular]}
 
 dihydrofolate reductase [dihydrofolic acid [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [5,6,7,8-tetrahydrofolic acid [intracellular]] + [NADP(+) [intracellular]];   {5,6,7,8-tetrahydrofolic acid [intracellular]} , {dihydrofolic acid [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 dihydroorotase [H+ [intracellular]] + [N-carbamoyl-L-aspartate [intracellular]] ↔ [(S)-dihydroorotate [intracellular]] + [water [intracellular]];   {(S)-dihydroorotate [intracellular]} , {H+ [intracellular]} , {N-carbamoyl-L-aspartate [intracellular]} , {water [intracellular]}
 
 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) [(R)-2,3-dihydroxy-3-methylbutanoate [intracellular]] ↔ [3-methyl-2-oxobutanoate [intracellular]] + [water [intracellular]];   {(R)-2,3-dihydroxy-3-methylbutanoate [intracellular]} , {3-methyl-2-oxobutanoate [intracellular]} , {water [intracellular]}
 
 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) [(2R,3R)-2,3-dihydroxy-3-methylpentanoate [intracellular]] ↔ [(S)-3-methyl-2-oxopentanoate [intracellular]] + [water [intracellular]];   {(2R,3R)-2,3-dihydroxy-3-methylpentanoate [intracellular]} , {(S)-3-methyl-2-oxopentanoate [intracellular]} , {water [intracellular]}
 
 dihydroxyacetone kinase [ATP [intracellular]] + [glycerone [intracellular]] ↔ [ADP [intracellular]] + [glycerone phosphate [intracellular]] + [H+ [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {glycerone [intracellular]} , {glycerone phosphate [intracellular]} , {H+ [intracellular]}
 
 dimethylallyltranstransferase [isopentenyl diphosphate [intracellular]] + [prenyl diphosphate [intracellular]] ↔ [diphosphate [intracellular]] + [geranyl diphosphate [intracellular]];   {diphosphate [intracellular]} , {geranyl diphosphate [intracellular]} , {isopentenyl diphosphate [intracellular]} , {prenyl diphosphate [intracellular]}
 
 dolichyl-phosphate D-mannosyltransferase [dolichyl phosphate [intracellular]] + [GDP-alpha-D-mannose [intracellular]] ↔ [dolichyl D-mannosyl phosphate [intracellular]] + [GDP [intracellular]];   {dolichyl D-mannosyl phosphate [intracellular]} , {dolichyl phosphate [intracellular]} , {GDP [intracellular]} , {GDP-alpha-D-mannose [intracellular]}
 
 dolichyl-phosphate-mannose--protein mannosyltransferase [dolichyl D-mannosyl phosphate [intracellular]] ↔ [dolichyl phosphate [intracellular]] + [H+ [intracellular]] + [mannan [intracellular]];   {dolichyl D-mannosyl phosphate [intracellular]} , {dolichyl phosphate [intracellular]} , {H+ [intracellular]} , {mannan [intracellular]}
 
 enolase [2-phospho-D-glyceric acid [intracellular]] ↔ [phosphoenolpyruvate [intracellular]] + [water [intracellular]];   {2-phospho-D-glyceric acid [intracellular]} , {phosphoenolpyruvate [intracellular]} , {water [intracellular]}
 
 fatty acid synthase (n-C10:0) 3.0 × [H+ [intracellular]] + [malonyl-CoA [intracellular]] + 2.0 × [NADPH [intracellular]] + [octanoate [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + [decanoate [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {decanoate [intracellular]} , {H+ [intracellular]} , {malonyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {octanoate [intracellular]} , {water [intracellular]}
 
 fatty acid synthase (n-C12:0) [decanoate [intracellular]] + 3.0 × [H+ [intracellular]] + [malonyl-CoA [intracellular]] + 2.0 × [NADPH [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + [laurate [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {decanoate [intracellular]} , {H+ [intracellular]} , {laurate [intracellular]} , {malonyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {water [intracellular]}
 
 fatty acid synthase (n-C14:0) 3.0 × [H+ [intracellular]] + [laurate [intracellular]] + [malonyl-CoA [intracellular]] + 2.0 × [NADPH [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + [myristate [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {laurate [intracellular]} , {malonyl-CoA [intracellular]} , {myristate [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {water [intracellular]}
 
 fatty acid synthase (n-C16:0) 3.0 × [H+ [intracellular]] + [malonyl-CoA [intracellular]] + [myristate [intracellular]] + 2.0 × [NADPH [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [palmitate [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {malonyl-CoA [intracellular]} , {myristate [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {palmitate [intracellular]} , {water [intracellular]}
 
 fatty acid synthase (n-C18:0) 3.0 × [H+ [intracellular]] + [malonyl-CoA [intracellular]] + 2.0 × [NADPH [intracellular]] + [palmitate [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [stearate [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {malonyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {palmitate [intracellular]} , {stearate [intracellular]} , {water [intracellular]}
 
 fatty acid synthase (n-C24:0), lumped reaction 9.0 × [H+ [intracellular]] + 3.0 × [malonyl-CoA [intracellular]] + 6.0 × [NADPH [intracellular]] + [stearate [intracellular]] ↔ 3.0 × [carbon dioxide [intracellular]] + 3.0 × [coenzyme A [intracellular]] + [lignocerate [intracellular]] + 6.0 × [NADP(+) [intracellular]] + 3.0 × [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {lignocerate [intracellular]} , {malonyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {stearate [intracellular]} , {water [intracellular]}
 
 fatty acyl-CoA synthase (n-C10:0CoA) 3.0 × [H+ [intracellular]] + [malonyl-CoA [intracellular]] + 2.0 × [NADPH [intracellular]] + [octanoyl-CoA [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + [decanoyl-CoA [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {decanoyl-CoA [intracellular]} , {H+ [intracellular]} , {malonyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {octanoyl-CoA [intracellular]} , {water [intracellular]}
 
 fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction [acetyl-CoA [intracellular]] + 9.0 × [H+ [intracellular]] + 3.0 × [malonyl-CoA [intracellular]] + 6.0 × [NADPH [intracellular]] ↔ 3.0 × [carbon dioxide [intracellular]] + 3.0 × [coenzyme A [intracellular]] + 6.0 × [NADP(+) [intracellular]] + [octanoyl-CoA [intracellular]] + 3.0 × [water [intracellular]];   {acetyl-CoA [intracellular]} , {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {malonyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {octanoyl-CoA [intracellular]} , {water [intracellular]}
 
 fatty-acid--CoA ligase (n-C24:0) [ATP [intracellular]] + [coenzyme A [intracellular]] + [lignocerate [intracellular]] ↔ [AMP [intracellular]] + [diphosphate [intracellular]] + [tetracosanoyl-CoA [intracellular]];   {AMP [intracellular]} , {ATP [intracellular]} , {coenzyme A [intracellular]} , {diphosphate [intracellular]} , {lignocerate [intracellular]} , {tetracosanoyl-CoA [intracellular]}
 
 fatty-acid--CoA ligase (octadecanoate) [AMP [intracellular]] + [diphosphate [intracellular]] + [stearoyl-CoA [intracellular]] ↔ [ATP [intracellular]] + [coenzyme A [intracellular]] + [stearate [intracellular]];   {AMP [intracellular]} , {ATP [intracellular]} , {coenzyme A [intracellular]} , {diphosphate [intracellular]} , {stearate [intracellular]} , {stearoyl-CoA [intracellular]}
 
 fatty-acid--CoA ligase (octanoate) [AMP [intracellular]] + [diphosphate [intracellular]] + [octanoyl-CoA [intracellular]] ↔ [ATP [intracellular]] + [coenzyme A [intracellular]] + [octanoate [intracellular]];   {AMP [intracellular]} , {ATP [intracellular]} , {coenzyme A [intracellular]} , {diphosphate [intracellular]} , {octanoate [intracellular]} , {octanoyl-CoA [intracellular]}
 
 fatty-acyl-CoA synthase (n-C12:0CoA) [decanoyl-CoA [intracellular]] + 3.0 × [H+ [intracellular]] + [malonyl-CoA [intracellular]] + 2.0 × [NADPH [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + [lauroyl-CoA [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {decanoyl-CoA [intracellular]} , {H+ [intracellular]} , {lauroyl-CoA [intracellular]} , {malonyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {water [intracellular]}
 
 fatty-acyl-CoA synthase (n-C14:0CoA) 3.0 × [H+ [intracellular]] + [lauroyl-CoA [intracellular]] + [malonyl-CoA [intracellular]] + 2.0 × [NADPH [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + [myristoyl-CoA [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {lauroyl-CoA [intracellular]} , {malonyl-CoA [intracellular]} , {myristoyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {water [intracellular]}
 
 fatty-acyl-CoA synthase (n-C16:0CoA) 3.0 × [H+ [intracellular]] + [malonyl-CoA [intracellular]] + [myristoyl-CoA [intracellular]] + 2.0 × [NADPH [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [palmitoyl-CoA [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {malonyl-CoA [intracellular]} , {myristoyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {palmitoyl-CoA [intracellular]} , {water [intracellular]}
 
 fatty-acyl-CoA synthase (n-C18:0CoA) 3.0 × [H+ [intracellular]] + [malonyl-CoA [intracellular]] + 2.0 × [NADPH [intracellular]] + [palmitoyl-CoA [intracellular]] ↔ [carbon dioxide [intracellular]] + [coenzyme A [intracellular]] + 2.0 × [NADP(+) [intracellular]] + [stearoyl-CoA [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {malonyl-CoA [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {palmitoyl-CoA [intracellular]} , {stearoyl-CoA [intracellular]} , {water [intracellular]}
 
 formate-tetrahydrofolate ligase [5,6,7,8-tetrahydrofolic acid [intracellular]] + [ATP [intracellular]] + [formate [intracellular]] ↔ [10-formyltetrahydrofolic acid [intracellular]] + [ADP [intracellular]] + [phosphate [intracellular]];   {10-formyltetrahydrofolic acid [intracellular]} , {5,6,7,8-tetrahydrofolic acid [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {formate [intracellular]} , {phosphate [intracellular]}
 
 fructose-bisphosphate aldolase [D-fructose 1,6-bisphosphate [intracellular]] ↔ [glyceraldehyde 3-phosphate [intracellular]] + [glycerone phosphate [intracellular]];   {D-fructose 1,6-bisphosphate [intracellular]} , {glyceraldehyde 3-phosphate [intracellular]} , {glycerone phosphate [intracellular]}
 
 fumarase [(S)-malate(2-) [intracellular]] ↔ [fumarate(2-) [intracellular]] + [water [intracellular]];   {(S)-malate(2-) [intracellular]} , {fumarate(2-) [intracellular]} , {water [intracellular]}
 
 fumarate reductase [FADH2 [intracellular]] + [fumarate(2-) [intracellular]] ↔ [FAD [intracellular]] + [succinate(2-) [intracellular]];   {FAD [intracellular]} , {FADH2 [intracellular]} , {fumarate(2-) [intracellular]} , {succinate(2-) [intracellular]}
 
 geranyltranstransferase [geranyl diphosphate [intracellular]] + [isopentenyl diphosphate [intracellular]] ↔ [2-trans,6-trans-farnesyl diphosphate [intracellular]] + [diphosphate [intracellular]];   {2-trans,6-trans-farnesyl diphosphate [intracellular]} , {diphosphate [intracellular]} , {geranyl diphosphate [intracellular]} , {isopentenyl diphosphate [intracellular]}
 
 glucokinase [ATP [intracellular]] + [D-glucose [intracellular]] ↔ [ADP [intracellular]] + [beta-D-glucose 6-phosphate [intracellular]] + [H+ [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {beta-D-glucose 6-phosphate [intracellular]} , {D-glucose [intracellular]} , {H+ [intracellular]}
 
 glucose-6-phosphate isomerase [beta-D-glucose 6-phosphate [intracellular]] ↔ [D-fructose 6-phosphate [intracellular]];   {beta-D-glucose 6-phosphate [intracellular]} , {D-glucose [intracellular]} , {beta-D-glucose 6-phosphate [intracellular]} , {D-fructose 6-phosphate [intracellular]} , {D-glucose [intracellular]}
 
 glucose-6-phosphate isomerase_2 [aldehydo-D-glucose 6-phosphate [intracellular]] ↔ [D-fructose 6-phosphate [intracellular]];   {aldehydo-D-glucose 6-phosphate [intracellular]} , {D-fructose 6-phosphate [intracellular]}
 
 glutamate 5-kinase [ATP [intracellular]] + [L-glutamate [intracellular]] ↔ [ADP [intracellular]] + [L-gamma-glutamyl phosphate [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {L-gamma-glutamyl phosphate [intracellular]} , {L-glutamate [intracellular]}
 
 glutamate dehydrogenase (NADP) [2-oxoglutarate [intracellular]] + [ammonium [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [L-glutamate [intracellular]] + [NADP(+) [intracellular]] + [water [intracellular]];   {2-oxoglutarate [intracellular]} , {ammonium [intracellular]} , {H+ [intracellular]} , {L-glutamate [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {water [intracellular]}
 
 glutamate synthase (NADH2) [2-oxoglutarate [intracellular]] + [H+ [intracellular]] + [L-glutamine [intracellular]] + [NADH [intracellular]] ↔ 2.0 × [L-glutamate [intracellular]] + [NAD(+) [intracellular]];   {2-oxoglutarate [intracellular]} , {H+ [intracellular]} , {L-glutamate [intracellular]} , {L-glutamine [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 glutamate-5-semialdehyde dehydrogenase [H+ [intracellular]] + [L-gamma-glutamyl phosphate [intracellular]] + [NADH [intracellular]] ↔ [L-glutamic 5-semialdehyde [intracellular]] + [NAD(+) [intracellular]] + [phosphate [intracellular]];   {H+ [intracellular]} , {L-gamma-glutamyl phosphate [intracellular]} , {L-glutamic 5-semialdehyde [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {phosphate [intracellular]}
 
 glutamine phosphoribosyldiphosphate amidotransferase [5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]] + [L-glutamine [intracellular]] + [water [intracellular]] ↔ [5-phospho-beta-D-ribosylamine [intracellular]] + [diphosphate [intracellular]] + [L-glutamate [intracellular]];   {5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]} , {5-phospho-beta-D-ribosylamine [intracellular]} , {diphosphate [intracellular]} , {L-glutamate [intracellular]} , {L-glutamine [intracellular]} , {water [intracellular]}
 
 glutamine synthetase [ammonium [intracellular]] + [ATP [intracellular]] + [L-glutamate [intracellular]] ↔ [ADP [intracellular]] + [H+ [intracellular]] + [L-glutamine [intracellular]] + [phosphate [intracellular]];   {ADP [intracellular]} , {ammonium [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]} , {L-glutamate [intracellular]} , {L-glutamine [intracellular]} , {phosphate [intracellular]}
 
 glyceraldehyde-3-phosphate dehydrogenase [glyceraldehyde 3-phosphate [intracellular]] + [NAD(+) [intracellular]] + [phosphate [intracellular]] ↔ [3-phospho-D-glyceroyl dihydrogen phosphate [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]];   {glyceraldehyde 3-phosphate [intracellular]} , {glyceraldehyde 3-phosphate [intracellular]} , {NAD(+) [intracellular]} , {phosphate [intracellular]} , {3-phospho-D-glyceroyl dihydrogen phosphate [intracellular]} , {H+ [intracellular]} , {NADH [intracellular]}
 
 glycerol dehydrogenase (NADP-dependent) [glycerol [intracellular]] + [NADP(+) [intracellular]] ↔ [glycerone [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]];   {glycerol [intracellular]} , {glycerone [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 glycerol-3-phosphatase [sn-glycerol 3-phosphate [intracellular]] + [water [intracellular]] ↔ [glycerol [intracellular]] + [phosphate [intracellular]];   {glycerol [intracellular]} , {phosphate [intracellular]} , {sn-glycerol 3-phosphate [intracellular]} , {water [intracellular]}
 
 glycerol-3-phosphate dehydrogenase (fad) [FAD [intracellular]] + [sn-glycerol 3-phosphate [intracellular]] ↔ [FADH2 [intracellular]] + [glycerone phosphate [intracellular]];   {FAD [intracellular]} , {FADH2 [intracellular]} , {glycerone phosphate [intracellular]} , {sn-glycerol 3-phosphate [intracellular]}
 
 glycerol-3-phosphate dehydrogenase (NAD) [glycerone phosphate [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]] ↔ [NAD(+) [intracellular]] + [sn-glycerol 3-phosphate [intracellular]];   {glycerone phosphate [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {sn-glycerol 3-phosphate [intracellular]}
 
 glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase [acyl-CoA [intracellular]] + [sn-glycerol 3-phosphate [intracellular]] ↔ [1-acyl-sn-glycerol 3-phosphate [intracellular]] + [coenzyme A [intracellular]] + 2.0 × [H+ [intracellular]];   {1-acyl-sn-glycerol 3-phosphate [intracellular]} , {acyl-CoA [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {sn-glycerol 3-phosphate [intracellular]}
 
 glycine cleavage system [5,6,7,8-tetrahydrofolic acid [intracellular]] + [glycine [intracellular]] + [NAD(+) [intracellular]] ↔ [5,10-methylenetetrahydrofolate(2-) [intracellular]] + [ammonium [intracellular]] + [carbon dioxide [intracellular]] + [NADH [intracellular]];   {5,10-methylenetetrahydrofolate(2-) [intracellular]} , {5,6,7,8-tetrahydrofolic acid [intracellular]} , {ammonium [intracellular]} , {carbon dioxide [intracellular]} , {glycine [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 glycine hydroxymethyltransferase [5,10-methylenetetrahydrofolate(2-) [intracellular]] + [glycine [intracellular]] + [water [intracellular]] ↔ [5,6,7,8-tetrahydrofolic acid [intracellular]] + [L-serine [intracellular]];   {5,10-methylenetetrahydrofolate(2-) [intracellular]} , {5,6,7,8-tetrahydrofolic acid [intracellular]} , {glycine [intracellular]} , {L-serine [intracellular]} , {water [intracellular]}
 
 glycogen (starch) synthase [UDP-D-glucose [intracellular]] + [water [intracellular]] ↔ [amylose [intracellular]] + [H+ [intracellular]] + [UDP [intracellular]];   {amylose [intracellular]} , {H+ [intracellular]} , {UDP [intracellular]} , {UDP-D-glucose [intracellular]} , {water [intracellular]}
 
 GMP synthase [5'-xanthylic acid [intracellular]] + [ATP [intracellular]] + [L-glutamine [intracellular]] + [water [intracellular]] ↔ [AMP [intracellular]] + [diphosphate [intracellular]] + [GMP [intracellular]] + 2.0 × [H+ [intracellular]] + [L-glutamate [intracellular]];   {5'-xanthylic acid [intracellular]} , {AMP [intracellular]} , {ATP [intracellular]} , {diphosphate [intracellular]} , {GMP [intracellular]} , {H+ [intracellular]} , {L-glutamate [intracellular]} , {L-glutamine [intracellular]} , {water [intracellular]}
 
 GTP cyclohydrolase II [GTP [intracellular]] + 3.0 × [water [intracellular]] ↔ [2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine [intracellular]] + [diphosphate [intracellular]] + [formate [intracellular]] + 2.0 × [H+ [intracellular]];   {2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine [intracellular]} , {diphosphate [intracellular]} , {formate [intracellular]} , {GTP [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 guanylate kinase (GMP:ATP) [ATP [intracellular]] + [GMP [intracellular]] ↔ [ADP [intracellular]] + [GDP [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {GDP [intracellular]} , {GMP [intracellular]}
 
 guanylate kinase (GMP:dATP) [dATP [intracellular]] + [GMP [intracellular]] ↔ [dADP [intracellular]] + [GDP [intracellular]];   {dADP [intracellular]} , {dATP [intracellular]} , {GDP [intracellular]} , {GMP [intracellular]}
 
 hexokinase (D-glucose:ATP) [ATP [intracellular]] + [D-glucose [intracellular]] ↔ [ADP [intracellular]] + [aldehydo-D-glucose 6-phosphate [intracellular]] + [H+ [intracellular]];   {ADP [intracellular]} , {aldehydo-D-glucose 6-phosphate [intracellular]} , {ATP [intracellular]} , {D-glucose [intracellular]} , {H+ [intracellular]}
 
 histidinol dehydrogenase [L-histidinol [intracellular]] + 2.0 × [NAD(+) [intracellular]] + [water [intracellular]] ↔ 3.0 × [H+ [intracellular]] + [L-histidine [intracellular]] + 2.0 × [NADH [intracellular]];   {H+ [intracellular]} , {L-histidine [intracellular]} , {L-histidinol [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {water [intracellular]}
 
 histidinol-phosphatase [L-histidinol phosphate [intracellular]] + [water [intracellular]] ↔ [L-histidinol [intracellular]] + [phosphate [intracellular]];   {L-histidinol [intracellular]} , {L-histidinol phosphate [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 histidinol-phosphate transaminase [3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate [intracellular]] + [L-glutamate [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [L-histidinol phosphate [intracellular]];   {2-oxoglutarate [intracellular]} , {3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate [intracellular]} , {L-glutamate [intracellular]} , {L-histidinol phosphate [intracellular]}
 
 homoacontinate hydratase [but-1-ene-1,2,4-tricarboxylic acid [intracellular]] + [water [intracellular]] ↔ [homoisocitrate(3-) [intracellular]];   {but-1-ene-1,2,4-tricarboxylic acid [intracellular]} , {homoisocitrate(3-) [intracellular]} , {water [intracellular]}
 
 homocitrate synthase [2-oxoglutarate [intracellular]] + [acetyl-CoA [intracellular]] + [water [intracellular]] ↔ [coenzyme A [intracellular]] + [H+ [intracellular]] + [homocitrate(3-) [intracellular]];   {2-oxoglutarate [intracellular]} , {acetyl-CoA [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {homocitrate(3-) [intracellular]} , {water [intracellular]}
 
 homoisocitrate dehydrogenase [homoisocitrate(3-) [intracellular]] + [NAD(+) [intracellular]] ↔ [2-oxaloglutaric acid [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]];   {2-oxaloglutaric acid [intracellular]} , {H+ [intracellular]} , {homoisocitrate(3-) [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 homoserine dehydrogenase (NADH) [H+ [intracellular]] + [L-aspartate 4-semialdehyde [intracellular]] + [NADH [intracellular]] ↔ [L-homoserine [intracellular]] + [NAD(+) [intracellular]];   {H+ [intracellular]} , {L-aspartate 4-semialdehyde [intracellular]} , {L-homoserine [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 homoserine kinase [ATP [intracellular]] + [L-homoserine [intracellular]] ↔ [ADP [intracellular]] + [H+ [intracellular]] + [O-phospho-L-homoserine [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]} , {L-homoserine [intracellular]} , {O-phospho-L-homoserine [intracellular]}
 
 homoserine O-trans-acetylase [acetyl-CoA [intracellular]] + [L-homoserine [intracellular]] ↔ [coenzyme A [intracellular]] + [O-acetyl-L-homoserine [intracellular]];   {acetyl-CoA [intracellular]} , {coenzyme A [intracellular]} , {L-homoserine [intracellular]} , {O-acetyl-L-homoserine [intracellular]}
 
 hydroxymethylglutaryl CoA reductase [3-hydroxy-3-methylglutaryl-CoA [intracellular]] + 2.0 × [H+ [intracellular]] + 2.0 × [NADPH [intracellular]] ↔ [(R)-mevalonate [intracellular]] + [coenzyme A [intracellular]] + 2.0 × [NADP(+) [intracellular]];   {(R)-mevalonate [intracellular]} , {3-hydroxy-3-methylglutaryl-CoA [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 hydroxymethylglutaryl CoA synthase [acetoacetyl-CoA [intracellular]] + [acetyl-CoA [intracellular]] + [water [intracellular]] ↔ [3-hydroxy-3-methylglutaryl-CoA [intracellular]] + [coenzyme A [intracellular]] + [H+ [intracellular]];   {3-hydroxy-3-methylglutaryl-CoA [intracellular]} , {acetoacetyl-CoA [intracellular]} , {acetyl-CoA [intracellular]} , {coenzyme A [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 Imidazole-glycerol-3-phosphate synthase [5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]] + [L-glutamine [intracellular]] ↔ [5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]] + [D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate [intracellular]] + [H+ [intracellular]] + [L-glutamate [intracellular]];   {5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]} , {5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]} , {D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate [intracellular]} , {H+ [intracellular]} , {L-glutamate [intracellular]} , {L-glutamine [intracellular]}
 
 imidazoleglycerol-phosphate dehydratase [D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate [intracellular]] ↔ [3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate [intracellular]] + [water [intracellular]];   {3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate [intracellular]} , {D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate [intracellular]} , {water [intracellular]}
 
 IMP cyclohydrolase [5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]] ↔ [IMP [intracellular]] + [water [intracellular]];   {5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]} , {IMP [intracellular]} , {water [intracellular]}
 
 IMP dehydrogenase [IMP [intracellular]] + [NAD(+) [intracellular]] + [water [intracellular]] ↔ [5'-xanthylic acid [intracellular]] + [H+ [intracellular]] + [NADH [intracellular]];   {5'-xanthylic acid [intracellular]} , {H+ [intracellular]} , {IMP [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {water [intracellular]}
 
 indole-3-glycerol-phosphate synthase [1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate [intracellular]] + [H+ [intracellular]] ↔ [1-C-(indol-3-yl)glycerol 3-phosphate [intracellular]] + [carbon dioxide [intracellular]] + [water [intracellular]];   {1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate [intracellular]} , {1-C-(indol-3-yl)glycerol 3-phosphate [intracellular]} , {carbon dioxide [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 inorganic diphosphatase [diphosphate [intracellular]] + [water [intracellular]] ↔ [H+ [intracellular]] + 2.0 × [phosphate [intracellular]];   {diphosphate [intracellular]} , {H+ [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 inositolphosphotransferase [1D-myo-inositol 1-phosphate [intracellular]] + [mannosylinositol phosphorylceramide [intracellular]] ↔ [inositol phosphomannosylinositol phosphoceramide [intracellular]];   {1D-myo-inositol 1-phosphate [intracellular]} , {inositol phosphomannosylinositol phosphoceramide [intracellular]} , {mannosylinositol phosphorylceramide [intracellular]}
 
 IPC synthase [1D-myo-inositol 1-phosphate [intracellular]] + [N-(24-hydroxytetracosanyl)sphinganine [intracellular]] ↔ [inositol-P-ceramide B [intracellular]];   {1D-myo-inositol 1-phosphate [intracellular]} , {inositol-P-ceramide B [intracellular]} , {N-(24-hydroxytetracosanyl)sphinganine [intracellular]}
 
 isocitrate dehydrogenase (NADP) [isocitrate(3-) [intracellular]] + [NADP(+) [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [carbon dioxide [intracellular]] + [NADPH [intracellular]];   {2-oxoglutarate [intracellular]} , {carbon dioxide [intracellular]} , {isocitrate(3-) [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 isocitrate lyase [isocitrate(3-) [intracellular]] ↔ [glyoxylate [intracellular]] + [succinate(2-) [intracellular]];   {glyoxylate [intracellular]} , {isocitrate(3-) [intracellular]} , {succinate(2-) [intracellular]}
 
 isoleucine transaminase [(S)-3-methyl-2-oxopentanoate [intracellular]] + [L-glutamate [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [L-isoleucine [intracellular]];   {(S)-3-methyl-2-oxopentanoate [intracellular]} , {2-oxoglutarate [intracellular]} , {L-glutamate [intracellular]} , {L-isoleucine [intracellular]}
 
 isopentenyl-diphosphate D-isomerase [isopentenyl diphosphate [intracellular]] ↔ [prenyl diphosphate [intracellular]];   {isopentenyl diphosphate [intracellular]} , {prenyl diphosphate [intracellular]}
 
 ketol-acid reductoisomerase (2-aceto-2-hydroxybutanoate) [(S)-2-acetyl-2-hydroxybutanoate [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [(2R,3R)-2,3-dihydroxy-3-methylpentanoate [intracellular]] + [NADP(+) [intracellular]];   {(2R,3R)-2,3-dihydroxy-3-methylpentanoate [intracellular]} , {(S)-2-acetyl-2-hydroxybutanoate [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 L-alanine transaminase [L-glutamate [intracellular]] + [pyruvate [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [L-alanine [intracellular]];   {2-oxoglutarate [intracellular]} , {L-alanine [intracellular]} , {L-glutamate [intracellular]} , {pyruvate [intracellular]}
 
 L-aminoadipate-semialdehyde dehydrogenase (NADH) [ATP [intracellular]] + [H+ [intracellular]] + [L-2-aminoadipate(2-) [intracellular]] + [NADH [intracellular]] ↔ [AMP [intracellular]] + [diphosphate [intracellular]] + [L-allysine [intracellular]] + [NAD(+) [intracellular]];   {AMP [intracellular]} , {ATP [intracellular]} , {diphosphate [intracellular]} , {H+ [intracellular]} , {L-2-aminoadipate(2-) [intracellular]} , {L-allysine [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]}
 
 L-glutamate 5-semialdehyde dehydratase [L-glutamic 5-semialdehyde [intracellular]] ↔ [1-pyrroline-5-carboxylate [intracellular]] + [H+ [intracellular]] + [water [intracellular]];   {1-pyrroline-5-carboxylate [intracellular]} , {H+ [intracellular]} , {L-glutamic 5-semialdehyde [intracellular]} , {water [intracellular]}
 
 L-hydroxyproline dehydrogenase (NADP) [NADP(+) [intracellular]] + [trans-4-hydroxy-L-proline [intracellular]] ↔ [1-pyrroline-3-hydroxy-5-carboxylic acid [intracellular]] + 2.0 × [H+ [intracellular]] + [NADPH [intracellular]];   {1-pyrroline-3-hydroxy-5-carboxylic acid [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {trans-4-hydroxy-L-proline [intracellular]}
 
 L-hydroxyproline reductase (NAD) [1-pyrroline-3-hydroxy-5-carboxylic acid [intracellular]] + 2.0 × [H+ [intracellular]] + [NADH [intracellular]] ↔ [NAD(+) [intracellular]] + [trans-4-hydroxy-L-proline [intracellular]];   {1-pyrroline-3-hydroxy-5-carboxylic acid [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {trans-4-hydroxy-L-proline [intracellular]}
 
 L-threonine deaminase [L-threonine [intracellular]] ↔ [2-oxobutanoate [intracellular]] + [ammonium [intracellular]];   {2-oxobutanoate [intracellular]} , {ammonium [intracellular]} , {L-threonine [intracellular]}
 
 lanosterol synthase [(S)-2,3-epoxysqualene [intracellular]] ↔ [lanosterol [intracellular]];   {(S)-2,3-epoxysqualene [intracellular]} , {lanosterol [intracellular]}
 
 leucine transaminase [4-methyl-2-oxopentanoate [intracellular]] + [L-glutamate [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [L-leucine [intracellular]];   {2-oxoglutarate [intracellular]} , {4-methyl-2-oxopentanoate [intracellular]} , {L-glutamate [intracellular]} , {L-leucine [intracellular]}
 
 malate dehydrogenase [H+ [intracellular]] + [NADH [intracellular]] + [oxaloacetate(2-) [intracellular]] ↔ [(S)-malate(2-) [intracellular]] + [NAD(+) [intracellular]];   {(S)-malate(2-) [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {oxaloacetate(2-) [intracellular]}
 
 mannose-1-phosphate guanylyltransferase [D-mannose 1-phosphate [intracellular]] + [GTP [intracellular]] + [H+ [intracellular]] ↔ [diphosphate [intracellular]] + [GDP-alpha-D-mannose [intracellular]];   {D-mannose 1-phosphate [intracellular]} , {diphosphate [intracellular]} , {GDP-alpha-D-mannose [intracellular]} , {GTP [intracellular]} , {H+ [intracellular]}
 
 mannose-6-phosphate isomerase [D-fructose 6-phosphate [intracellular]] ↔ [D-mannose 6-phosphate [intracellular]];   {D-fructose 6-phosphate [intracellular]} , {D-mannose 6-phosphate [intracellular]}
 
 methenyltetrahydrifikate cyclohydrolase [(6R)-5,10-methenyltetrahydrofolic acid [intracellular]] + [water [intracellular]] ↔ [10-formyltetrahydrofolic acid [intracellular]] + [H+ [intracellular]];   {(6R)-5,10-methenyltetrahydrofolic acid [intracellular]} , {10-formyltetrahydrofolic acid [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 methionine adenosyltransferase [ATP [intracellular]] + [L-methionine [intracellular]] + [water [intracellular]] ↔ [diphosphate [intracellular]] + [phosphate [intracellular]] + [S-adenosyl-L-methionine [intracellular]];   {ATP [intracellular]} , {diphosphate [intracellular]} , {L-methionine [intracellular]} , {phosphate [intracellular]} , {S-adenosyl-L-methionine [intracellular]} , {water [intracellular]}
 
 methionine synthase [5-methyltetrahydrofolate(2-) [intracellular]] + [L-homocysteine [intracellular]] ↔ [5,6,7,8-tetrahydrofolic acid [intracellular]] + [H+ [intracellular]] + [L-methionine [intracellular]];   {5,6,7,8-tetrahydrofolic acid [intracellular]} , {5-methyltetrahydrofolate(2-) [intracellular]} , {H+ [intracellular]} , {L-homocysteine [intracellular]} , {L-methionine [intracellular]}
 
 methylenetetrahydrofolate dehydrogenase (NADP) [5,10-methylenetetrahydrofolate(2-) [intracellular]] + [NADP(+) [intracellular]] ↔ [(6R)-5,10-methenyltetrahydrofolic acid [intracellular]] + [NADPH [intracellular]];   {(6R)-5,10-methenyltetrahydrofolic acid [intracellular]} , {5,10-methylenetetrahydrofolate(2-) [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 mevalonate kinase (ctp) [(R)-mevalonate [intracellular]] + [CTP [intracellular]] ↔ [(R)-5-phosphomevalonic acid [intracellular]] + [CDP [intracellular]] + [H+ [intracellular]];   {(R)-5-phosphomevalonic acid [intracellular]} , {(R)-mevalonate [intracellular]} , {CDP [intracellular]} , {CTP [intracellular]} , {H+ [intracellular]}
 
 mevalonate pyrophoshate decarboxylase [(R)-5-diphosphomevalonic acid [intracellular]] + [ATP [intracellular]] ↔ [ADP [intracellular]] + [carbon dioxide [intracellular]] + [isopentenyl diphosphate [intracellular]] + [phosphate [intracellular]];   {(R)-5-diphosphomevalonic acid [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {carbon dioxide [intracellular]} , {isopentenyl diphosphate [intracellular]} , {phosphate [intracellular]}
 
 microsomal beta-keto-reductase [(S)-3-hydroxyhexacosanoyl-CoA [intracellular]] + [NADP(+) [intracellular]] ↔ [3-oxohexacosanoyl-CoA [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]];   {(S)-3-hydroxyhexacosanoyl-CoA [intracellular]} , {3-oxohexacosanoyl-CoA [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 microsomal beta-keto-reductase_2 [(S)-3-hydroxypalmitoyl-CoA [intracellular]] + [NADP(+) [intracellular]] ↔ [3-oxopalmitoyl-CoA [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]];   {(S)-3-hydroxypalmitoyl-CoA [intracellular]} , {3-oxopalmitoyl-CoA [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 microsomal beta-keto-reductase_3 [3-hydroxyoctadecanoyl-CoA [intracellular]] + [NADP(+) [intracellular]] ↔ [3-oxooctadecanoyl-CoA [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]];   {3-hydroxyoctadecanoyl-CoA [intracellular]} , {3-oxooctadecanoyl-CoA [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 microsomal beta-keto-reductase_4 [(S)-3-hydroxytetradecanoyl-CoA [intracellular]] + [NADP(+) [intracellular]] ↔ [3-oxotetradecanoyl-CoA [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]];   {(S)-3-hydroxytetradecanoyl-CoA [intracellular]} , {3-oxotetradecanoyl-CoA [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 MIPC synthase [GDP-alpha-D-mannose [intracellular]] + [inositol-P-ceramide B [intracellular]] ↔ [mannosylinositol phosphorylceramide [intracellular]];   {GDP-alpha-D-mannose [intracellular]} , {inositol-P-ceramide B [intracellular]} , {mannosylinositol phosphorylceramide [intracellular]}
 
 myo-inositol 1-phosphatase [1D-myo-inositol 1-phosphate [intracellular]] + [water [intracellular]] ↔ [myo-inositol [intracellular]] + [phosphate [intracellular]];   {1D-myo-inositol 1-phosphate [intracellular]} , {myo-inositol [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 myo-inositol-1-phosphate synthase [aldehydo-D-glucose 6-phosphate [intracellular]] ↔ [1D-myo-inositol 1-phosphate [intracellular]];   {1D-myo-inositol 1-phosphate [intracellular]} , {aldehydo-D-glucose 6-phosphate [intracellular]}
 
 N-acetyl-g-glutamyl-phosphate reductase [H+ [intracellular]] + [N-acetyl-L-gamma-glutamyl phosphate [intracellular]] + [NADPH [intracellular]] ↔ [2-acetamido-5-oxopentanoate [intracellular]] + [NADP(+) [intracellular]] + [phosphate [intracellular]];   {2-acetamido-5-oxopentanoate [intracellular]} , {H+ [intracellular]} , {N-acetyl-L-gamma-glutamyl phosphate [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {phosphate [intracellular]}
 
 non-enzymatic reaction [2-oxaloglutaric acid [intracellular]] + [H+ [intracellular]] ↔ [2-oxoadipic acid [intracellular]] + [carbon dioxide [intracellular]];   {2-oxaloglutaric acid [intracellular]} , {2-oxoadipic acid [intracellular]} , {carbon dioxide [intracellular]} , {H+ [intracellular]}
 
 nucleoside-diphosphate kinase (ATP:CDP) [ADP [intracellular]] + [CTP [intracellular]] ↔ [ATP [intracellular]] + [CDP [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {CDP [intracellular]} , {CTP [intracellular]}
 
 nucleoside-diphosphate kinase (ATP:UDP) [ATP [intracellular]] + [UDP [intracellular]] ↔ [ADP [intracellular]] + [UTP [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {UDP [intracellular]} , {UTP [intracellular]}
 
 O-acetylhomoserine (thiol)-lyase [hydrogen sulfide [intracellular]] + [O-acetyl-L-homoserine [intracellular]] ↔ [acetate [intracellular]] + [H+ [intracellular]] + [L-homocysteine [intracellular]];   {acetate [intracellular]} , {H+ [intracellular]} , {hydrogen sulfide [intracellular]} , {L-homocysteine [intracellular]} , {O-acetyl-L-homoserine [intracellular]}
 
 ornithine carbamoyltransferase [carbamoyl phosphate [intracellular]] + [ornithine [intracellular]] ↔ [H+ [intracellular]] + [L-citrulline [intracellular]] + [phosphate [intracellular]];   {carbamoyl phosphate [intracellular]} , {H+ [intracellular]} , {L-citrulline [intracellular]} , {ornithine [intracellular]} , {phosphate [intracellular]}
 
 ornithine transacetylase [L-glutamate [intracellular]] + [N(2)-acetyl-L-ornithine [intracellular]] ↔ [N-acetyl-L-glutamate(2-) [intracellular]] + [ornithine [intracellular]];   {L-glutamate [intracellular]} , {N(2)-acetyl-L-ornithine [intracellular]} , {N-acetyl-L-glutamate(2-) [intracellular]} , {ornithine [intracellular]}
 
 orotate phosphoribosyltransferase [5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]] + [orotate [intracellular]] ↔ [diphosphate [intracellular]] + [orotidine 5'-(dihydrogen phosphate) [intracellular]];   {5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]} , {diphosphate [intracellular]} , {orotate [intracellular]} , {orotidine 5'-(dihydrogen phosphate) [intracellular]}
 
 orotidine-5'-phosphate decarboxylase [H+ [intracellular]] + [orotidine 5'-(dihydrogen phosphate) [intracellular]] ↔ [carbon dioxide [intracellular]] + [UMP [intracellular]];   {carbon dioxide [intracellular]} , {H+ [intracellular]} , {orotidine 5'-(dihydrogen phosphate) [intracellular]} , {UMP [intracellular]}
 
 phenylalanine transaminase [keto-phenylpyruvate [intracellular]] + [L-glutamate [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [L-phenylalanine [intracellular]];   {2-oxoglutarate [intracellular]} , {keto-phenylpyruvate [intracellular]} , {L-glutamate [intracellular]} , {L-phenylalanine [intracellular]}
 
 phosphatidylethanolamine methyltransferase [phosphatidylethanolamine [intracellular]] + [S-adenosyl-L-methionine [intracellular]] ↔ [H+ [intracellular]] + [phosphatidyl-N-methylethanolamine [intracellular]] + [S-adenosyl-L-homocysteine [intracellular]];   {H+ [intracellular]} , {phosphatidyl-N-methylethanolamine [intracellular]} , {phosphatidylethanolamine [intracellular]} , {S-adenosyl-L-homocysteine [intracellular]} , {S-adenosyl-L-methionine [intracellular]}
 
 phosphatidylinositol synthase [CDP-diacylglycerol [intracellular]] + [myo-inositol [intracellular]] ↔ [1-phosphatidyl-1D-myo-inositol [intracellular]] + [CMP [intracellular]] + 2.0 × [H+ [intracellular]];   {1-phosphatidyl-1D-myo-inositol [intracellular]} , {CDP-diacylglycerol [intracellular]} , {CMP [intracellular]} , {H+ [intracellular]} , {myo-inositol [intracellular]}
 
 phosphatidylserine decarboxylase [phosphatidyl-L-serine [intracellular]] ↔ [carbon dioxide [intracellular]] + [phosphatidylethanolamine [intracellular]];   {carbon dioxide [intracellular]} , {phosphatidyl-L-serine [intracellular]} , {phosphatidylethanolamine [intracellular]}
 
 phosphatidylserine synthase [CDP-diacylglycerol [intracellular]] + [L-serine [intracellular]] ↔ [CMP [intracellular]] + 2.0 × [H+ [intracellular]] + [phosphatidyl-L-serine [intracellular]];   {CDP-diacylglycerol [intracellular]} , {CMP [intracellular]} , {H+ [intracellular]} , {L-serine [intracellular]} , {phosphatidyl-L-serine [intracellular]}
 
 phosphoadenylyl-sulfate reductase (thioredoxin) [3'-phospho-5'-adenylyl sulfate [intracellular]] + [thioredoxin dithiol [intracellular]] ↔ [adenosine 3',5'-bismonophosphate [intracellular]] + 2.0 × [H+ [intracellular]] + [sulphite [intracellular]] + [thioredoxin disulfide [intracellular]];   {3'-phospho-5'-adenylyl sulfate [intracellular]} , {adenosine 3',5'-bismonophosphate [intracellular]} , {H+ [intracellular]} , {sulphite [intracellular]} , {thioredoxin disulfide [intracellular]} , {thioredoxin dithiol [intracellular]}
 
 phosphofructokinase [ATP [intracellular]] + [D-fructose 6-phosphate [intracellular]] ↔ [ADP [intracellular]] + [D-fructose 1,6-bisphosphate [intracellular]] + [H+ [intracellular]];   {ATP [intracellular]} , {ATP [intracellular]} , {D-fructose 6-phosphate [intracellular]} , {ADP [intracellular]} , {D-fructose 1,6-bisphosphate [intracellular]} , {H+ [intracellular]}
 
 phosphoglucomutase [aldehydo-D-glucose 6-phosphate [intracellular]] ↔ [D-glucose 1-phosphate [intracellular]];   {aldehydo-D-glucose 6-phosphate [intracellular]} , {D-glucose 1-phosphate [intracellular]}
 
 phosphoglycerate kinase [3-phospho-D-glyceroyl dihydrogen phosphate [intracellular]] + [ADP [intracellular]] ↔ [3-phospho-D-glyceric acid [intracellular]] + [ATP [intracellular]];   {ATP [intracellular]} , {3-phospho-D-glyceroyl dihydrogen phosphate [intracellular]} , {ADP [intracellular]} , {3-phospho-D-glyceric acid [intracellular]} , {ATP [intracellular]}
 
 phosphoglycerate mutase [3-phospho-D-glyceric acid [intracellular]] ↔ [2-phospho-D-glyceric acid [intracellular]];   {2-phospho-D-glyceric acid [intracellular]} , {3-phospho-D-glyceric acid [intracellular]} , {2-phospho-D-glyceric acid [intracellular]}
 
 phospholipid methyltransferase [phosphatidyl-N,N-dimethylethanolamine [intracellular]] + [S-adenosyl-L-methionine [intracellular]] ↔ [phosphatidylcholine [intracellular]] + [S-adenosyl-L-homocysteine [intracellular]];   {phosphatidyl-N,N-dimethylethanolamine [intracellular]} , {phosphatidylcholine [intracellular]} , {S-adenosyl-L-homocysteine [intracellular]} , {S-adenosyl-L-methionine [intracellular]}
 
 phospholipid methyltransferase_2 [phosphatidyl-N-methylethanolamine [intracellular]] + [S-adenosyl-L-methionine [intracellular]] ↔ [H+ [intracellular]] + [phosphatidyl-N,N-dimethylethanolamine [intracellular]] + [S-adenosyl-L-homocysteine [intracellular]];   {H+ [intracellular]} , {phosphatidyl-N,N-dimethylethanolamine [intracellular]} , {phosphatidyl-N-methylethanolamine [intracellular]} , {S-adenosyl-L-homocysteine [intracellular]} , {S-adenosyl-L-methionine [intracellular]}
 
 phosphomannomutase [D-mannose 6-phosphate [intracellular]] ↔ [D-mannose 1-phosphate [intracellular]];   {D-mannose 1-phosphate [intracellular]} , {D-mannose 6-phosphate [intracellular]}
 
 phosphomevalonate kinase [(R)-5-phosphomevalonic acid [intracellular]] + [ATP [intracellular]] ↔ [(R)-5-diphosphomevalonic acid [intracellular]] + [ADP [intracellular]];   {(R)-5-diphosphomevalonic acid [intracellular]} , {(R)-5-phosphomevalonic acid [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]}
 
 phosphoribosyl-AMP cyclohydrolase [1-(5-phosphoribosyl)-5'-AMP [intracellular]] + [water [intracellular]] ↔ [1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide [intracellular]];   {1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide [intracellular]} , {1-(5-phosphoribosyl)-5'-AMP [intracellular]} , {water [intracellular]}
 
 phosphoribosyl-ATP pyrophosphatase [5-phosphoribosyl-ATP [intracellular]] + [water [intracellular]] ↔ [1-(5-phosphoribosyl)-5'-AMP [intracellular]] + [diphosphate [intracellular]] + [H+ [intracellular]];   {1-(5-phosphoribosyl)-5'-AMP [intracellular]} , {5-phosphoribosyl-ATP [intracellular]} , {diphosphate [intracellular]} , {H+ [intracellular]} , {water [intracellular]}
 
 phosphoribosylaminoimidazole carboxylase [5-amino-1-(5-phospho-D-ribosyl)imidazole [intracellular]] + [carbon dioxide [intracellular]] ↔ [5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid [intracellular]] + [H+ [intracellular]];   {5-amino-1-(5-phospho-D-ribosyl)imidazole [intracellular]} , {5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid [intracellular]} , {carbon dioxide [intracellular]} , {H+ [intracellular]}
 
 phosphoribosylaminoimidazole synthase [2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine [intracellular]] + [ATP [intracellular]] ↔ [5-amino-1-(5-phospho-D-ribosyl)imidazole [intracellular]] + [ADP [intracellular]] + 2.0 × [H+ [intracellular]] + [phosphate [intracellular]];   {2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine [intracellular]} , {5-amino-1-(5-phospho-D-ribosyl)imidazole [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]} , {phosphate [intracellular]}
 
 phosphoribosylaminoimidazolecarboxamide formyltransferase [10-formyltetrahydrofolic acid [intracellular]] + [5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]] ↔ [5,6,7,8-tetrahydrofolic acid [intracellular]] + [5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]];   {10-formyltetrahydrofolic acid [intracellular]} , {5,6,7,8-tetrahydrofolic acid [intracellular]} , {5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]} , {5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [intracellular]}
 
 phosphoribosylaminoimidazolesuccinocarboxamide synthase [5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid [intracellular]] + [ATP [intracellular]] + [L-aspartate [intracellular]] ↔ [(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid [intracellular]] + [ADP [intracellular]] + [H+ [intracellular]] + [phosphate [intracellular]];   {(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid [intracellular]} , {5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]} , {L-aspartate [intracellular]} , {phosphate [intracellular]}
 
 phosphoribosylanthranilate isomerase [N-(5-phospho-beta-D-ribosyl)anthranilate [intracellular]] ↔ [1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate [intracellular]];   {1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate [intracellular]} , {N-(5-phospho-beta-D-ribosyl)anthranilate [intracellular]}
 
 phosphoribosylformylglycinamidine synthase [ATP [intracellular]] + [L-glutamine [intracellular]] + [N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular]] + [water [intracellular]] ↔ [2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine [intracellular]] + [ADP [intracellular]] + [H+ [intracellular]] + [L-glutamate [intracellular]] + [phosphate [intracellular]];   {2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]} , {L-glutamate [intracellular]} , {L-glutamine [intracellular]} , {N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 phosphoribosylglycinamide formyltransferase [10-formyltetrahydrofolic acid [intracellular]] + [N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular]] ↔ [5,6,7,8-tetrahydrofolic acid [intracellular]] + [H+ [intracellular]] + [N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular]];   {10-formyltetrahydrofolic acid [intracellular]} , {5,6,7,8-tetrahydrofolic acid [intracellular]} , {H+ [intracellular]} , {N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular]} , {N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular]}
 
 phosphoribosylglycinamide synthase [5-phospho-beta-D-ribosylamine [intracellular]] + [ATP [intracellular]] + [glycine [intracellular]] ↔ [ADP [intracellular]] + [H+ [intracellular]] + [N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular]] + [phosphate [intracellular]];   {5-phospho-beta-D-ribosylamine [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {glycine [intracellular]} , {H+ [intracellular]} , {N(1)-(5-phospho-D-ribosyl)glycinamide [intracellular]} , {phosphate [intracellular]}
 
 phosphoribosylpyrophosphate synthetase [alpha-D-ribose 5-phosphate [intracellular]] + [ATP [intracellular]] ↔ [5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]] + [AMP [intracellular]] + [H+ [intracellular]];   {5-O-phosphono-alpha-D-ribofuranosyl diphosphate [intracellular]} , {alpha-D-ribose 5-phosphate [intracellular]} , {AMP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]}
 
 prephenate dehydratase [H+ [intracellular]] + [prephenate(2-) [intracellular]] ↔ [carbon dioxide [intracellular]] + [keto-phenylpyruvate [intracellular]] + [water [intracellular]];   {carbon dioxide [intracellular]} , {H+ [intracellular]} , {keto-phenylpyruvate [intracellular]} , {prephenate(2-) [intracellular]} , {water [intracellular]}
 
 prephenate dehydrogenase (NADP) [NADP(+) [intracellular]] + [prephenate(2-) [intracellular]] ↔ [3-(4-hydroxyphenyl)pyruvate [intracellular]] + [carbon dioxide [intracellular]] + [NADPH [intracellular]];   {3-(4-hydroxyphenyl)pyruvate [intracellular]} , {carbon dioxide [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {prephenate(2-) [intracellular]}
 
 pyrimidine phosphatase [5-amino-6-(5-phosphoribitylamino)uracil [intracellular]] + [water [intracellular]] ↔ [5-amino-6-(D-ribitylamino)uracil [intracellular]] + [phosphate [intracellular]];   {5-amino-6-(5-phosphoribitylamino)uracil [intracellular]} , {5-amino-6-(D-ribitylamino)uracil [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 pyrroline-5-carboxylate reductase [1-pyrroline-5-carboxylate [intracellular]] + 2.0 × [H+ [intracellular]] + [NADPH [intracellular]] ↔ [L-proline [intracellular]] + [NADP(+) [intracellular]];   {1-pyrroline-5-carboxylate [intracellular]} , {H+ [intracellular]} , {L-proline [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]}
 
 pyruvate carboxylase [ATP [intracellular]] + [bicarbonate [intracellular]] + [pyruvate [intracellular]] ↔ [ADP [intracellular]] + [H+ [intracellular]] + [oxaloacetate(2-) [intracellular]] + [phosphate [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {bicarbonate [intracellular]} , {H+ [intracellular]} , {oxaloacetate(2-) [intracellular]} , {phosphate [intracellular]} , {pyruvate [intracellular]}
 
 pyruvate decarboxylase [H+ [intracellular]] + [pyruvate [intracellular]] ↔ [acetaldehyde [intracellular]] + [carbon dioxide [intracellular]];   {pyruvate [intracellular]} , {H+ [intracellular]} , {pyruvate [intracellular]} , {acetaldehyde [intracellular]} , {carbon dioxide [intracellular]}
 
 pyruvate dehydrogenase [coenzyme A [intracellular]] + [NAD(+) [intracellular]] + [pyruvate [intracellular]] ↔ [acetyl-CoA [intracellular]] + [carbon dioxide [intracellular]] + [NADH [intracellular]];   {acetyl-CoA [intracellular]} , {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {pyruvate [intracellular]}
 
 pyruvate kinase [ADP [intracellular]] + [H+ [intracellular]] + [phosphoenolpyruvate [intracellular]] ↔ [ATP [intracellular]] + [pyruvate [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]} , {phosphoenolpyruvate [intracellular]} , {pyruvate [intracellular]}
 
 riboflavin synthase [2-hydroxy-3-oxobutyl phosphate [intracellular]] + [5-amino-6-(D-ribitylamino)uracil [intracellular]] ↔ [6,7-dimethyl-8-(1-D-ribityl)lumazine [intracellular]] + [phosphate [intracellular]] + 2.0 × [water [intracellular]];   {2-hydroxy-3-oxobutyl phosphate [intracellular]} , {5-amino-6-(D-ribitylamino)uracil [intracellular]} , {6,7-dimethyl-8-(1-D-ribityl)lumazine [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 riboflavin synthase_2 2.0 × [6,7-dimethyl-8-(1-D-ribityl)lumazine [intracellular]] ↔ [5-amino-6-(D-ribitylamino)uracil [intracellular]] + [riboflavin [intracellular]];   {5-amino-6-(D-ribitylamino)uracil [intracellular]} , {6,7-dimethyl-8-(1-D-ribityl)lumazine [intracellular]} , {riboflavin [intracellular]}
 
 ribonucleoside-diphosphate reductase [ADP [intracellular]] + [thioredoxin dithiol [intracellular]] ↔ [dADP [intracellular]] + [water [intracellular]] + [thioredoxin disulfide [intracellular]];   {ADP [intracellular]} , {dADP [intracellular]} , {water [intracellular]} , {thioredoxin disulfide [intracellular]} , {thioredoxin dithiol [intracellular]}
 
 ribonucleoside-diphosphate reductase (GDP) [GDP [intracellular]] + [thioredoxin dithiol [intracellular]] ↔ [dGDP [intracellular]] + [water [intracellular]] + [thioredoxin disulfide [intracellular]];   {dGDP [intracellular]} , {GDP [intracellular]} , {water [intracellular]} , {thioredoxin disulfide [intracellular]} , {thioredoxin dithiol [intracellular]}
 
 ribonucleoside-diphosphate reductase (UDP) [UDP [intracellular]] + [thioredoxin dithiol [intracellular]] ↔ [dUDP [intracellular]] + [water [intracellular]] + [thioredoxin disulfide [intracellular]];   {dUDP [intracellular]} , {UDP [intracellular]} , {water [intracellular]} , {thioredoxin disulfide [intracellular]} , {thioredoxin dithiol [intracellular]}
 
 ribonucleoside-triphosphate reductase (ATP) [ATP [intracellular]] + [thioredoxin dithiol [intracellular]] ↔ [dATP [intracellular]] + [water [intracellular]] + [thioredoxin disulfide [intracellular]];   {ATP [intracellular]} , {dATP [intracellular]} , {water [intracellular]} , {thioredoxin disulfide [intracellular]} , {thioredoxin dithiol [intracellular]}
 
 ribose-5-phosphate isomerase [D-ribulose 5-phosphate [intracellular]] ↔ [alpha-D-ribose 5-phosphate [intracellular]];   {alpha-D-ribose 5-phosphate [intracellular]} , {D-ribulose 5-phosphate [intracellular]}
 
 ribulose 5-phosphate 3-epimerase [D-xylulose 5-phosphate [intracellular]] ↔ [D-ribulose 5-phosphate [intracellular]];   {D-ribulose 5-phosphate [intracellular]} , {D-xylulose 5-phosphate [intracellular]}
 
 S-adenosyl-methionine delta-24-sterol-c-methyltransferase [S-adenosyl-L-methionine [intracellular]] + [zymosterol [intracellular]] ↔ [fecosterol [intracellular]] + [H+ [intracellular]] + [S-adenosyl-L-homocysteine [intracellular]];   {fecosterol [intracellular]} , {H+ [intracellular]} , {S-adenosyl-L-homocysteine [intracellular]} , {S-adenosyl-L-methionine [intracellular]} , {zymosterol [intracellular]}
 
 saccharopine dehydrogenase (NAD, L-lysine forming) [L-saccharopine [intracellular]] + [NAD(+) [intracellular]] + [water [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [H+ [intracellular]] + [L-lysine [intracellular]] + [NADH [intracellular]];   {2-oxoglutarate [intracellular]} , {H+ [intracellular]} , {L-lysine [intracellular]} , {L-saccharopine [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {water [intracellular]}
 
 saccharopine dehydrogenase (NADP, L-glutamate forming) [H+ [intracellular]] + [L-allysine [intracellular]] + [L-glutamate [intracellular]] + [NADPH [intracellular]] ↔ [L-saccharopine [intracellular]] + [NADP(+) [intracellular]] + [water [intracellular]];   {H+ [intracellular]} , {L-allysine [intracellular]} , {L-glutamate [intracellular]} , {L-saccharopine [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {water [intracellular]}
 
 serine C-palmitoyltransferase [L-serine [intracellular]] + [palmitoyl-CoA [intracellular]] ↔ [3-dehydrosphinganine [intracellular]] + [carbon dioxide [intracellular]] + [coenzyme A [intracellular]];   {3-dehydrosphinganine [intracellular]} , {carbon dioxide [intracellular]} , {coenzyme A [intracellular]} , {L-serine [intracellular]} , {palmitoyl-CoA [intracellular]}
 
 shikimate dehydrogenase [3-dehydroshikimate [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ [NADP(+) [intracellular]] + [shikimate [intracellular]];   {3-dehydroshikimate [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {shikimate [intracellular]}
 
 shikimate kinase [ATP [intracellular]] + [shikimate [intracellular]] ↔ [3-phosphoshikimic acid [intracellular]] + [ADP [intracellular]] + [H+ [intracellular]];   {3-phosphoshikimic acid [intracellular]} , {ADP [intracellular]} , {ATP [intracellular]} , {H+ [intracellular]} , {shikimate [intracellular]}
 
 squalene epoxidase (NAD) [H+ [intracellular]] + [NADH [intracellular]] + [oxygen [intracellular]] + [squalene [intracellular]] ↔ [(S)-2,3-epoxysqualene [intracellular]] + [NAD(+) [intracellular]] + [water [intracellular]];   {(S)-2,3-epoxysqualene [intracellular]} , {H+ [intracellular]} , {NAD(+) [intracellular]} , {NADH [intracellular]} , {oxygen [intracellular]} , {squalene [intracellular]} , {water [intracellular]}
 
 squalene synthase 2.0 × [2-trans,6-trans-farnesyl diphosphate [intracellular]] + [H+ [intracellular]] + [NADPH [intracellular]] ↔ 2.0 × [diphosphate [intracellular]] + [NADP(+) [intracellular]] + [squalene [intracellular]];   {2-trans,6-trans-farnesyl diphosphate [intracellular]} , {diphosphate [intracellular]} , {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {squalene [intracellular]}
 
 steryl ester hydrolase [ergosterol [intracellular]] + [fatty acid [intracellular]] ↔ [ergosterol ester [intracellular]] + [water [intracellular]];   {ergosterol [intracellular]} , {ergosterol ester [intracellular]} , {fatty acid [intracellular]} , {water [intracellular]}
 
 succinate-CoA ligase (ADP-forming) [ATP [intracellular]] + [coenzyme A [intracellular]] + [succinate(2-) [intracellular]] ↔ [ADP [intracellular]] + [phosphate [intracellular]] + [succinyl-CoA [intracellular]];   {ADP [intracellular]} , {ATP [intracellular]} , {coenzyme A [intracellular]} , {phosphate [intracellular]} , {succinate(2-) [intracellular]} , {succinyl-CoA [intracellular]}
 
 sulfate adenylyltransferase (ADP) [ADP [intracellular]] + [H+ [intracellular]] + [sulphate [intracellular]] ↔ [5'-adenylyl sulfate [intracellular]] + [phosphate [intracellular]];   {5'-adenylyl sulfate [intracellular]} , {ADP [intracellular]} , {H+ [intracellular]} , {phosphate [intracellular]} , {sulphate [intracellular]}
 
 sulfite reductase (NADPH2) 5.0 × [H+ [intracellular]] + 3.0 × [NADPH [intracellular]] + [sulphite [intracellular]] ↔ [hydrogen sulfide [intracellular]] + 3.0 × [NADP(+) [intracellular]] + 3.0 × [water [intracellular]];   {H+ [intracellular]} , {hydrogen sulfide [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {sulphite [intracellular]} , {water [intracellular]}
 
 thioredoxin reductase (NADPH) [H+ [intracellular]] + [NADPH [intracellular]] + [thioredoxin disulfide [intracellular]] ↔ [NADP(+) [intracellular]] + [thioredoxin dithiol [intracellular]];   {H+ [intracellular]} , {NADP(+) [intracellular]} , {NADPH [intracellular]} , {thioredoxin disulfide [intracellular]} , {thioredoxin dithiol [intracellular]}
 
 threonine aldolase [L-threonine [intracellular]] ↔ [acetaldehyde [intracellular]] + [glycine [intracellular]];   {acetaldehyde [intracellular]} , {glycine [intracellular]} , {L-threonine [intracellular]}
 
 threonine synthase [O-phospho-L-homoserine [intracellular]] + [water [intracellular]] ↔ [L-threonine [intracellular]] + [phosphate [intracellular]];   {L-threonine [intracellular]} , {O-phospho-L-homoserine [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 thymidylate synthase [5,10-methylenetetrahydrofolate(2-) [intracellular]] + [dUMP [intracellular]] ↔ [dihydrofolic acid [intracellular]] + [dTMP [intracellular]];   {5,10-methylenetetrahydrofolate(2-) [intracellular]} , {dihydrofolic acid [intracellular]} , {dTMP [intracellular]} , {dUMP [intracellular]}
 
 transaldolase [D-erythrose 4-phosphate(2-) [intracellular]] + [D-fructose 6-phosphate [intracellular]] ↔ [glyceraldehyde 3-phosphate [intracellular]] + [sedoheptulose 7-phosphate [intracellular]];   {D-erythrose 4-phosphate(2-) [intracellular]} , {D-fructose 6-phosphate [intracellular]} , {glyceraldehyde 3-phosphate [intracellular]} , {sedoheptulose 7-phosphate [intracellular]}
 
 transketolase [glyceraldehyde 3-phosphate [intracellular]] + [sedoheptulose 7-phosphate [intracellular]] ↔ [alpha-D-ribose 5-phosphate [intracellular]] + [D-xylulose 5-phosphate [intracellular]];   {alpha-D-ribose 5-phosphate [intracellular]} , {D-xylulose 5-phosphate [intracellular]} , {glyceraldehyde 3-phosphate [intracellular]} , {sedoheptulose 7-phosphate [intracellular]}
 
 transketolase_2 [D-fructose 6-phosphate [intracellular]] + [glyceraldehyde 3-phosphate [intracellular]] ↔ [D-erythrose 4-phosphate(2-) [intracellular]] + [D-xylulose 5-phosphate [intracellular]];   {D-erythrose 4-phosphate(2-) [intracellular]} , {D-fructose 6-phosphate [intracellular]} , {D-xylulose 5-phosphate [intracellular]} , {glyceraldehyde 3-phosphate [intracellular]}
 
 trehalose-phosphatase [alpha,alpha-trehalose 6-phosphate [intracellular]] + [water [intracellular]] ↔ [alpha,alpha-trehalose [intracellular]] + [phosphate [intracellular]];   {alpha,alpha-trehalose [intracellular]} , {alpha,alpha-trehalose 6-phosphate [intracellular]} , {phosphate [intracellular]} , {water [intracellular]}
 
 triacylglycerol lipase [triglyceride [intracellular]] + [water [intracellular]] ↔ [diglyceride [intracellular]] + [fatty acid [intracellular]];   {diglyceride [intracellular]} , {fatty acid [intracellular]} , {triglyceride [intracellular]} , {water [intracellular]}
 
 triose-phosphate isomerase [glycerone phosphate [intracellular]] ↔ [glyceraldehyde 3-phosphate [intracellular]];   {glyceraldehyde 3-phosphate [intracellular]} , {glycerone phosphate [intracellular]}
 
 tryptophan synthase (indoleglycerol phosphate) [1-C-(indol-3-yl)glycerol 3-phosphate [intracellular]] + [L-serine [intracellular]] ↔ [glyceraldehyde 3-phosphate [intracellular]] + [L-tryptophan [intracellular]] + [water [intracellular]];   {1-C-(indol-3-yl)glycerol 3-phosphate [intracellular]} , {glyceraldehyde 3-phosphate [intracellular]} , {L-serine [intracellular]} , {L-tryptophan [intracellular]} , {water [intracellular]}
 
 tyrosine transaminase [3-(4-hydroxyphenyl)pyruvate [intracellular]] + [L-glutamate [intracellular]] ↔ [2-oxoglutarate [intracellular]] + [L-tyrosine [intracellular]];   {2-oxoglutarate [intracellular]} , {3-(4-hydroxyphenyl)pyruvate [intracellular]} , {L-glutamate [intracellular]} , {L-tyrosine [intracellular]}