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BIOMD0000000492 - Pathak2013 - MAPK activation in response to various biotic stresses

 

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Reference Publication
Publication ID: 23847397
Pathak RK, Taj G, Pandey D, Arora S, Kumar A.
Modeling of the MAPK machinery activation in response to various abiotic and biotic stresses in plants by a system biology approach.
Bioinformation 2013; 9(9): 443-449
Department of Molecular Biology & Genetic Engineering, College of Basic Sciences & Humanities, G.B. Pant University Of Agriculture & Technology, Pantnagar-263145, Uttarakhand, India.  [more]
Model
Original Model: Biotic.MAPK
Submitter: Anil Kumar
Submission ID: MODEL1308220000
Submission Date: 22 Aug 2013 03:34:57 UTC
Last Modification Date: 28 Apr 2014 15:40:00 UTC
Creation Date: 15 Nov 2013 12:03:14 UTC
Encoders:  Vijayalakshmi Chelliah
   Rajesh Kumar Pathak
set #1
bqbiol:occursIn Taxonomy Viridiplantae
bqbiol:isVersionOf Gene Ontology MAPK cascade
Gene Ontology response to stress
Gene Ontology cellular response to biotic stimulus
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
Notes
Pathak2013 - MAPK activation in response to various biotic stresses

MAPK activation mechanism in response to various biotic (fungal and bacterial pathogens) stress conditions in plants

This model is described in the article:

Pathak RK, Taj G, Pandey D, Arora S, Kumar A.
Bioinformation 2013; 9(9): 443-449

Abstract:

Mitogen-Activated Protein Kinases (MAPKs) cascade plays an important role in regulating plant growth and development, generating cellular responses to the extracellular stimuli. MAPKs cascade mainly consist of three sub-families i.e. mitogen-activated protein kinase kinase kinase (MAPKKK), mitogen-activated protein kinase kinase (MAPKK) and mitogen activated protein kinase (MAPK), several cascades of which are activated by various abiotic and biotic stresses. In this work we have modeled the holistic molecular mechanisms essential to MAPKs activation in response to several abiotic and biotic stresses through a system biology approach and performed its simulation studies. As extent of abiotic and biotic stresses goes on increasing, the process of cell division, cell growth and cell differentiation slow down in time dependent manner. The models developed depict the combinatorial and multicomponent signaling triggered in response to several abiotic and biotic factors. These models can be used to predict behavior of cells in event of various stresses depending on their time and exposure through activation of complex signaling cascades.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Model
Publication ID: 23847397 Submission Date: 22 Aug 2013 03:34:57 UTC Last Modification Date: 28 Apr 2014 15:40:00 UTC Creation Date: 15 Nov 2013 12:03:14 UTC
Mathematical expressions
Reactions
re1 re2 re3 re4
re5 re6 re7 re8
re9 re10 re11 re12
re13 re14 re15 re16
re17 re18 re19 re20
re21 re22 re23 re24
re25 re26 re27 re28
re29 re30 re31 re32
re33 re34 re35 re36
re37 re38 re39 re40
re41 re42 re43 re44
re45 re46 re47 re48
re49 re50 re51 re52
re53 re54 re55 re56
re57 re58 re59 re60
re61 re62 re63 re64
re65 re66 re67 re68
re69 re70 re71 re72
re73 re74 re75 re76
re77 re78 re79 re80
re81 re82 re83 re84
re85 re86 re87 re88
Physical entities
Compartments Species
default Fungal pathogen Bacterial pathogen Response
     
Cytosol LysM PRRs FLS2
LRR MAPKKK MAPKKK
MAPKKK1 MAPKKK18 MAPKKK19
MAPKKK20 EDR1 MAPKK
MAPKK MAPKK2 MAPKK4
MAPKK5 MAPKK9 MAPK
MAPK MAPK2 MAPK3
MAPK4 MAPK6 SIMK
SAMK    
Nucleus WRKY1 WRKY1 MYB2
MYB2 WRKY33 WRKY33
WRKY6 WRKY6 MYB4
MYB4 WRKY25 WRKY25
WRKY12 WRKY12 WRKY22
WRKY22 WRKY28 WRKY28
WRKY29 WRKY29 MYB44
NAC bZIP AP2
     
Global parameters
Dissociation constant of reaction re1 Association constant of reaction re1 Dissociation constant of reaction re2 Association constant of reaction re2
Dissociation constant of reaction re3 Association constant of reaction re3 Dissociation constant of reaction re4 Association constant of reaction re4
Dissociation constant of reaction re5 Association constant of reaction re5 Dissociation constant of reaction re6 Association constant of reaction re6
Dissociation constant of reaction re7 Association constant of reaction re7 Dissociation constant of reaction re8 Association constant of reaction re8
Dissociation constant of reaction re9 Association constant of reaction re9 Dissociation constant of reaction re10 Association constant of reaction re10
Dissociation constant of reaction re11 Association constant of reaction re11 Dissociation constant of reaction re12 Association constant of reaction re12
Dissociation constant of reaction re13 Association constant of reaction re13 Dissociation constant of reaction re14 Association constant of reaction re14
Dissociation constant of reaction re15 Association constant of reaction re15 Dissociation constant of reaction re16 Association constant of reaction re16
Dissociation constant of reaction re17 Association constant of reaction re17 Dissociation constant of reaction re18 Association constant of reaction re18
Dissociation constant of reaction re19 Association constant of reaction re19 Dissociation constant of reaction re20 Association constant of reaction re20
Dissociation constant of reaction re21 Association constant of reaction re21 Dissociation constant of reaction re22 Association constant of reaction re22
Dissociation constant of reaction re23 Association constant of reaction re23 Dissociation constant of reaction re24 Association constant of reaction re24
Dissociation constant of reaction re25 Association constant of reaction re25 Dissociation constant of reaction re26 Association constant of reaction re26
Dissociation constant of reaction re27 Association constant of reaction re27 Dissociation constant of reaction re28 Association constant of reaction re28
Dissociation constant of reaction re29 Association constant of reaction re29 Dissociation constant of reaction re30 Association constant of reaction re30
Dissociation constant of reaction re31 Association constant of reaction re31 Dissociation constant of reaction re32 Association constant of reaction re32
Dissociation constant of reaction re33 Association constant of reaction re33 Dissociation constant of reaction re34 Association constant of reaction re34
Dissociation constant of reaction re35 Association constant of reaction re35 Dissociation constant of reaction re36 Association constant of reaction re36
Dissociation constant of reaction re37 Association constant of reaction re37 Dissociation constant of reaction re38 Association constant of reaction re38
Dissociation constant of reaction re39 Association constant of reaction re39 Dissociation constant of reaction re40 Association constant of reaction re40
Dissociation constant of reaction re41 Association constant of reaction re41 Dissociation constant of reaction re42 Association constant of reaction re42
Dissociation constant of reaction re43 Association constant of reaction re43 Dissociation constant of reaction re44 Association constant of reaction re44
Dissociation constant of reaction re45 Association constant of reaction re45 Dissociation constant of reaction re46 Association constant of reaction re46
Dissociation constant of reaction re47 Association constant of reaction re47 Dissociation constant of reaction re48 Association constant of reaction re48
Dissociation constant of reaction re49 Association constant of reaction re49 Dissociation constant of reaction re50 Association constant of reaction re50
Dissociation constant of reaction re51 Association constant of reaction re51 Dissociation constant of reaction re52 Association constant of reaction re52
Dissociation constant of reaction re53 Association constant of reaction re53 Dissociation constant of reaction re54 Association constant of reaction re54
Dissociation constant of reaction re55 Association constant of reaction re55 Dissociation constant of reaction re56 Association constant of reaction re56
Dissociation constant of reaction re57 Association constant of reaction re57 Dissociation constant of reaction re58 Association constant of reaction re58
Dissociation constant of reaction re59 Association constant of reaction re59 Dissociation constant of reaction re60 Association constant of reaction re60
Dissociation constant of reaction re61 Association constant of reaction re61 Dissociation constant of reaction re62 Association constant of reaction re62
Dissociation constant of reaction re63 Association constant of reaction re63 Dissociation constant of reaction re64 Association constant of reaction re64
Dissociation constant of reaction re65 Association constant of reaction re65 Dissociation constant of reaction re66 Association constant of reaction re66
Dissociation constant of reaction re67 Association constant of reaction re67 Dissociation constant of reaction re68 Association constant of reaction re68
Dissociation constant of reaction re69 Association constant of reaction re69 Dissociation constant of reaction re70 Association constant of reaction re70
Dissociation constant of reaction re71 Association constant of reaction re71 Dissociation constant of reaction re72 Association constant of reaction re72
Dissociation constant of reaction re73 Association constant of reaction re73 Dissociation constant of reaction re74 Association constant of reaction re74
Dissociation constant of reaction re75 Association constant of reaction re75 Dissociation constant of reaction re76 Association constant of reaction re76
Dissociation constant of reaction re77 Association constant of reaction re77 Dissociation constant of reaction re78 Association constant of reaction re78
Dissociation constant of reaction re79 Association constant of reaction re79 Dissociation constant of reaction re80 Association constant of reaction re80
Dissociation constant of reaction re81 Association constant of reaction re81 Dissociation constant of reaction re82 Association constant of reaction re82
Dissociation constant of reaction re83 Association constant of reaction re83 Dissociation constant of reaction re84 Association constant of reaction re84
Dissociation constant of reaction re85 Association constant of reaction re85 Dissociation constant of reaction re86 Association constant of reaction re86
Dissociation constant of reaction re87 Association constant of reaction re87 Dissociation constant of reaction re88 Association constant of reaction re88
Reactions (88)
 
 re1 [Fungal pathogen] ↔ [LysM];  
 
 re2 [Fungal pathogen] ↔ [PRRs];  
 
 re3 [Fungal pathogen] ↔ [FLS2];  
 
 re4 [Bacterial pathogen] ↔ [PRRs];  
 
 re5 [Bacterial pathogen] ↔ [FLS2];  
 
 re6 [Bacterial pathogen] ↔ [LRR];  
 
 re7 [MAPKKK] ↔ [MAPKKK];  
 
 re8 [LysM] ↔ [MAPKKK];  
 
 re9 [PRRs] ↔ [MAPKKK];  
 
 re10 [FLS2] ↔ [MAPKKK];  
 
 re11 [LRR] ↔ [MAPKKK];  
 
 re12 [MAPKKK] ↔ [MAPKKK1];  
 
 re13 [MAPKKK] ↔ [MAPKKK18];  
 
 re14 [MAPKKK] ↔ [MAPKKK19];  
 
 re15 [MAPKKK] ↔ [MAPKKK20];  
 
 re16 [LRR] ↔ [MAPKKK1];  
 
 re17 [MAPKKK] ↔ [EDR1];  
 
 re18 [FLS2] ↔ [EDR1];  
 
 re19 [FLS2] ↔ [MAPKKK19];  
 
 re20 [MAPKK] ↔ [MAPKK];  
 
 re21 [MAPKKK] ↔ [MAPKK];  
 
 re22 [MAPKK] ↔ [MAPKK2];  
 
 re23 [MAPKK] ↔ [MAPKK4];  
 
 re24 [MAPKK] ↔ [MAPKK5];  
 
 re25 [MAPKK] ↔ [MAPKK9];  
 
 re26 [MAPKKK1] ↔ [MAPKK2];  
 
 re27 [MAPKKK1] ↔ [MAPKK4];  
 
 re28 [MAPKKK1] ↔ [MAPKK5];  
 
 re29 [MAPKKK19] ↔ [MAPKK9];  
 
 re30 [MAPK] ↔ [MAPK];  
 
 re31 [MAPKK] ↔ [MAPK];  
 
 re32 [MAPK] ↔ [MAPK2];  
 
 re33 [MAPK] ↔ [MAPK3];  
 
 re34 [MAPK] ↔ [MAPK4];  
 
 re35 [MAPK] ↔ [MAPK6];  
 
 re36 [MAPK] ↔ [SIMK];  
 
 re37 [MAPK] ↔ [SAMK];  
 
 re38 [MAPKK2] ↔ [MAPK2];  
 
 re39 [MAPKK4] ↔ [MAPK2];  
 
 re40 [MAPKK4] ↔ [MAPK3];  
 
 re41 [MAPKK5] ↔ [MAPK3];  
 
 re42 [MAPKK4] ↔ [MAPK6];  
 
 re43 [MAPKK2] ↔ [MAPK4];  
 
 re44 [MAPKK5] ↔ [MAPK6];  
 
 re45 [WRKY1] ↔ [WRKY1];  
 
 re46 [MYB2] ↔ [MYB2];  
 
 re47 [WRKY33] ↔ [WRKY33];  
 
 re48 [WRKY6] ↔ [WRKY6];  
 
 re49 [MYB4] ↔ [MYB4];  
 
 re50 [WRKY25] ↔ [WRKY25];  
 
 re51 [WRKY12] ↔ [WRKY12];  
 
 re52 [WRKY22] ↔ [WRKY22];  
 
 re53 [WRKY28] ↔ [WRKY28];  
 
 re54 [WRKY29] ↔ [WRKY29];  
 
 re55 [MAPK2] ↔ [WRKY1];  
 
 re56 [MAPK4] ↔ [WRKY1];  
 
 re57 [MAPK3] ↔ [WRKY33];  
 
 re58 [MAPK4] ↔ [WRKY33];  
 
 re59 [MAPK4] ↔ [WRKY25];  
 
 re60 [MAPK3] ↔ [WRKY22];  
 
 re61 [MAPK6] ↔ [WRKY22];  
 
 re62 [MAPK6] ↔ [WRKY29];  
 
 re63 [MAPK6] ↔ [WRKY33];  
 
 re64 [MAPK3] ↔ [WRKY29];  
 
 re65 [MAPK3] ↔ [WRKY28];  
 
 re66 [MAPK6] ↔ [WRKY28];  
 
 re67 [MAPK3] ↔ [WRKY12];  
 
 re68 [MAPK6] ↔ [MYB4];  
 
 re69 [MAPK] ↔ [MYB2];  
 
 re70 [MAPK] ↔ [MYB44];  
 
 re71 [MAPK] ↔ [NAC];  
 
 re72 [MAPK] ↔ [AP2];  
 
 re73 [MAPK] ↔ [bZIP];  
 
 re74 [MAPK4] ↔ [WRKY6];  
 
 re75 [WRKY28] ↔ [Response];  
 
 re76 [MYB2] ↔ [Response];  
 
 re77 [NAC] ↔ [Response];  
 
 re78 [bZIP] ↔ [Response];  
 
 re79 [AP2] ↔ [Response];  
 
 re80 [MYB44] ↔ [Response];  
 
 re81 [MYB4] ↔ [Response];  
 
 re82 [WRKY12] ↔ [Response];  
 
 re83 [WRKY6] ↔ [Response];  
 
 re84 [WRKY1] ↔ [Response];  
 
 re85 [WRKY29] ↔ [Response];  
 
 re86 [WRKY22] ↔ [Response];  
 
 re87 [WRKY25] ↔ [Response];  
 
 re88 [WRKY33] ↔ [Response];  
 
  Spatial dimensions: 3.0  Compartment size: 1.0  (Units: volume)
 
 Fungal pathogen
Compartment: default
Initial amount: 0.5  (Units: substance)
 
 Bacterial pathogen
Compartment: default
Initial amount: 0.5  (Units: substance)
 
 Response
Compartment: default
Initial amount: 2.5  (Units: substance)
 
 Cytosol Spatial dimensions: 3.0  Compartment size: 1.0  (Units: volume)
 
 LysM
Compartment: Cytosol
Initial amount: 0.8  (Units: substance)
 
 PRRs
Compartment: Cytosol
Initial amount: 0.8  (Units: substance)
 
 FLS2
Compartment: Cytosol
Initial amount: 0.8  (Units: substance)
 
 LRR
Compartment: Cytosol
Initial amount: 0.8  (Units: substance)
 
 MAPKKK
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKKK
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKKK1
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKKK18
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKKK19
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKKK20
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 EDR1
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKK
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKK
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKK2
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKK4
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKK5
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPKK9
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPK
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPK
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPK2
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPK3
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPK4
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 MAPK6
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 SIMK
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 SAMK
Compartment: Cytosol
Initial amount: 1.0  (Units: substance)
 
 Nucleus Spatial dimensions: 3.0  Compartment size: 1.0  (Units: volume)
 
 WRKY1
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY1
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 MYB2
Compartment: Nucleus
Initial amount: 1.5  (Units: substance)
 
 MYB2
Compartment: Nucleus
Initial amount: 1.5  (Units: substance)
 
 WRKY33
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY33
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY6
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY6
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 MYB4
Compartment: Nucleus
Initial amount: 1.5  (Units: substance)
 
 MYB4
Compartment: Nucleus
Initial amount: 1.5  (Units: substance)
 
 WRKY25
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY25
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY12
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY12
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY22
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY22
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY28
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY28
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY29
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 WRKY29
Compartment: Nucleus
Initial amount: 1.2  (Units: substance)
 
 MYB44
Compartment: Nucleus
Initial amount: 1.5  (Units: substance)
 
 NAC
Compartment: Nucleus
Initial amount: 1.8  (Units: substance)
 
 bZIP
Compartment: Nucleus
Initial amount: 2.0  (Units: substance)
 
 AP2
Compartment: Nucleus
Initial amount: 2.2  (Units: substance)
 
Global Parameters (176)
 
 Dissociation constant of reaction re1
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re1
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re2
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re2
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re3
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re3
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re4
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re4
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re5
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re5
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re6
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re6
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re7
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re7
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re8
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re8
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re9
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re9
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re10
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re10
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re11
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re11
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re12
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re12
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re13
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re13
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re14
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re14
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re15
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re15
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re16
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re16
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re17
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re17
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re18
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re18
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re19
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re19
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re20
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re20
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re21
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re21
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re22
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re22
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re23
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re23
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re24
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re24
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re25
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re25
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re26
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re26
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re27
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re27
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re28
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re28
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re29
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re29
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re30
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re30
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re31
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re31
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re32
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re32
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re33
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re33
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re34
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re34
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re35
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re35
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re36
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re36
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re37
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re37
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re38
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re38
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re39
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re39
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re40
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re40
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re41
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re41
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re42
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re42
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re43
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re43
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re44
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re44
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re45
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re45
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re46
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re46
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re47
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re47
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re48
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re48
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re49
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re49
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re50
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re50
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re51
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re51
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re52
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re52
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re53
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re53
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re54
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re54
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re55
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re55
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re56
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re56
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re57
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re57
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re58
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re58
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re59
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re59
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re60
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re60
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re61
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re61
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re62
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re62
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re63
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re63
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re64
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re64
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re65
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re65
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re66
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re66
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re67
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re67
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re68
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re68
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re69
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re69
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re70
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re70
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re71
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re71
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re72
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re72
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re73
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re73
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re74
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re74
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re75
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re75
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re76
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re76
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re77
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re77
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re78
Value: 1.0   (Units: per_second)
Constant
 
   Association constant of reaction re78
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re79
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re79
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re80
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re80
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re81
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re81
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re82
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re82
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re83
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re83
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re84
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re84
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re85
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re85
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re86
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re86
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re87
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re87
Value: 1.0   (Units: per_second)
Constant
 
 Dissociation constant of reaction re88
Value: 1.0   (Units: per_second)
Constant
 
 Association constant of reaction re88
Value: 1.0   (Units: per_second)
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000492

Curator's comment: (updated: 15 Nov 2013 12:02:56 GMT)

Figure 3b of the reference publication has been reproduced here. The model was simulated using SBML odeSolver and the plot was generated using Gnuplot.
Note: The model is not loading in Copasi (core dump error).

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