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BIOMD0000000474 - Smith2013 - Regulation of Insulin Signalling by Oxidative Stress

 

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Reference Publication
Publication ID: 23705851
Smith GR, Shanley DP.
Computational modelling of the regulation of Insulin signalling by oxidative stress.
BMC Syst Biol 2013; 7: 41
Centre for Integrated Systems Biology of Ageing & Nutrition (CISBAN), Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.  [more]
Model
Original Model: BIOMD0000000474.origin
Submitter: Graham Smith
Submission ID: MODEL1212210000
Submission Date: 21 Dec 2012 10:55:44 UTC
Last Modification Date: 10 Oct 2014 10:26:58 UTC
Creation Date: 06 Sep 2013 16:13:42 UTC
Encoders:  Vijayalakshmi Chelliah
   Graham Smith
set #1
bqbiol:hasPart Gene Ontology insulin receptor signaling pathway
Gene Ontology regulation of cellular response to oxidative stress
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
bqbiol:hasTaxon Taxonomy Rattus
bqbiol:occursIn Brenda Tissue Ontology adipocyte
bqmodel:isDerivedFrom BioModels Database Sedaghat2002_InsulinSignalling_noFeedback
set #2
bqbiol:hasProperty Human Disease Ontology diabetes mellitus
Notes
Smith2013 - Regulation of Insulin Signalling by Oxidative Stress

The model describes insulin signalling (in rodent adipocytes), which includes in addition to the core pathway, the transcriptional feedback through the Forkhead box type O (FOXO) transcription factor and interaction with oxidative stress.

This model is described in the article:

Smith GR, Shanley DP.
BMC Syst Biol. 2013 May 24;7:41.

Abstract:

BACKGROUND: Existing models of insulin signalling focus on short term dynamics, rather than the longer term dynamics necessary to understand many physiologically relevant behaviours. We have developed a model of insulin signalling in rodent adipocytes that includes both transcriptional feedback through the Forkhead box type O (FOXO) transcription factor, and interaction with oxidative stress, in addition to the core pathway. In the model Reactive Oxygen Species are both generated endogenously and can be applied externally. They regulate signalling though inhibition of phosphatases and induction of the activity of Stress Activated Protein Kinases, which themselves modulate feedbacks to insulin signalling and FOXO.

RESULTS: Insulin and oxidative stress combined produce a lower degree of activation of insulin signalling than insulin alone. Fasting (nutrient withdrawal) and weak oxidative stress upregulate antioxidant defences while stronger oxidative stress leads to a short term activation of insulin signalling but if prolonged can have other effects including degradation of the insulin receptor substrate (IRS1) and FOXO. At high insulin the protective effect of moderate oxidative stress may disappear.

CONCLUSION: Our model is consistent with a wide range of experimental data, some of which is difficult to explain. Oxidative stress can have effects that are both up- and down-regulatory on insulin signalling. Our model therefore shows the complexity of the interaction between the two pathways and highlights the need for such integrated computational models to give insight into the dysregulation of insulin signalling along with more data at the individual level.A complete SBML model file can be downloaded from BIOMODELS (https://www.ebi.ac.uk/biomodels-main) with unique identifier MODEL1212210000.Other files and scripts are available as additional files with this journal article and can be downloaded from https://github.com/graham1034/Smith2012_insulin_signalling.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Model
Publication ID: 23705851 Submission Date: 21 Dec 2012 10:55:44 UTC Last Modification Date: 10 Oct 2014 10:26:58 UTC Creation Date: 06 Sep 2013 16:13:42 UTC
Mathematical expressions
Reactions
R1f R1r R2 R3f
R3r R4 R5f R5r
R6f R6r R7f R7r
R10 R11 R14f R14r
R16f R16r R16a_f R16a_r
R17f R17r R20f R20r
R30f R30r R31f R31r
R34f R34r1 R34r2 R34r3
R35f R35r R36f R37f
R37r R38f R38r R12f
R12r R12_a_f R12_a_r R12_b_f
R12_b_r R13f R13r R50f
R50r1 R50r2 R50r3 R50r4
R51f R52f R42f R42r
R43f R43r R32f R32r
Synthesis transport cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0
transport dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 transport cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1
transport dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 transport cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0
transport dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 transport cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1
transport dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 transport cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0
transport dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 transport cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1
transport dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 transport cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0
transport dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 transport cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1
transport dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 transport cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0
transport dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 transport cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1
transport dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 transport cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0
transport dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 transport cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1
transport dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 transport cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0
transport dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 transport cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1
transport dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 transport cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0
transport dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 transport cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1
transport dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2
conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2
conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by Akt_P2 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by Akt_P2
conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by Akt_P2 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by Akt_P2 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by Akt_P2 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by Akt_P2
conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2
conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2
conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by SGK conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by SGK conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by SGK
conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK
conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK
conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by SGK conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by SGK conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by SGK
conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by SGK conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by SGK conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by SGK conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK
conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by SGK conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by SGK
conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by SGK conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A
conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A
conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A
conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A
conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A
conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by PP2A conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by PP2A
conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P
conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P
conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by IKK_P conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by IKK_P
conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by IKK_P conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A
conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A
conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A
conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P
conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by IKK_P
conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by IKK_P conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by IKK_P conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P
conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A
conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A
conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A
conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P
conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A
conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A
conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P
conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by JNK_P conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by JNK_P conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by JNK_P conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A
conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A
conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by JNK_P conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by JNK_P conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by JNK_P
conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A
conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A
conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P
conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A
conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by PP2A conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by PP2A
conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by PP2A conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by SCF conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by SCF conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by SCF
conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by SCF conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by SCF conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by SCF conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF
conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by SCF conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by SCF
conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by SCF conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF
conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by SCF
conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by SCF conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by SCF conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by SCF conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by SCF
conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by SCF degradation of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 degradation of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 degradation of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1
degradation of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 degradation of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 degradation of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 degradation of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1
degradation of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1
transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1
transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1
transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1
transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1
transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1
transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1
transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1
transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 basal transcription of InR export of InR RNA cyto degr of InR RNA
translation of InR degradation of InR protein basal transcription of SOD2 export of SOD2 RNA
cyto degr of SOD2 RNA translation of SOD2 degradation of SOD2 protein  
Rules
Assignment Rule (variable: JNK_plus_JNK_P) Assignment Rule (variable: IKK_plus_IKK_P) Assignment Rule (variable: DUSP_plus_DUSP_ox) Assignment Rule (variable: k_ros_perm)
Assignment Rule (variable: insconc) Assignment Rule (variable: Foxo1_Pa0_tot) Assignment Rule (variable: Foxo1_Pa1_tot) Assignment Rule (variable: Foxo1_Pd0_tot)
Assignment Rule (variable: Foxo1_Pd1_tot) Assignment Rule (variable: Foxo1_Pe0_tot) Assignment Rule (variable: Foxo1_Pe1_tot) Assignment Rule (variable: Foxo1_pUb0_tot)
Assignment Rule (variable: Foxo1_pUb1_tot) Assignment Rule (variable: cytoplasm_Foxo1_tot) Assignment Rule (variable: nucleus_Foxo1_tot) Assignment Rule (variable: dnabound_Foxo1_tot)
Assignment Rule (variable: Foxo1_all) Assignment Rule (variable: ros_ext_conc) Assignment Rule (variable: ros_cyto_conc) Assignment Rule (variable: PTP1B_plus_PTP1B_ox)
Assignment Rule (variable: PTEN_plus_PTEN_ox) Assignment Rule (variable: NOX_total) Assignment Rule (variable: IRS_total) Assignment Rule (variable: InR_tot)
Assignment Rule (variable: InR_bound) Assignment Rule (variable: InR_active) Assignment Rule (variable: PI345P3_mol) Assignment Rule (variable: PIP2_mol)
Assignment Rule (variable: rosconc)      
Physical entities
Compartments Species
extracellular Ins extracellular_ROS Foxo1_Pa0_tot
Foxo1_Pa1_tot Foxo1_Pd0_tot Foxo1_Pd1_tot
Foxo1_Pe0_tot Foxo1_Pe1_tot Foxo1_pUb0_tot
Foxo1_pUb1_tot cytoplasm_Foxo1_tot nucleus_Foxo1_tot
dnabound_Foxo1_tot Foxo1_all  
cellsurface InR Ins_InR Ins_InR_P
Ins_2_InR_P cellsurface_GLUT4  
cytoplasm NULL cytoplasm_InR cytoplasm_Ins_2_InR_P
cytoplasm_Ins_InR_P InR_tot InR_bound
InR_active PTP1B IRS1_TyrP_PI3K
PI345P3 PIP2 PI345P3_mol
PIP2_mol Akt Akt_P2
PKC PKC_P AS160
AS160_P cytoplasm_GLUT4 PTEN
PP2A PTP1B_ox PTP1B_plus_PTP1B_ox
PTEN_ox PTEN_plus_PTEN_ox ROS
GSH GSSG cytoplasm_SOD2
NOX_inact NOX NOX_deact
NOX_total Mt IRS1
IRS1_TyrP IRS1_PolySerP IRS1_TyrP_PolySerP
IRS_total PI3K JNK_P
IKK_P JNK JNK_plus_JNK_P
IKK IKK_plus_IKK_P DUSP
DUSP_ox DUSP_plus_DUSP_ox null
degr_Foxo1 cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1
cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0
cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1
cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0
cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1
cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 cytoplasm_RNA_InR
cytoplasm_RNA_SOD2 E2F1 SGK
CDK2 AMPK CBPP300
SIRT1 E3 USP7
SCF Proteasome  
nucleus nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0
nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1
nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0
nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1
nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0
nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 nucleus_RNA_InR nucleus_RNA_SOD2
     
dnabound dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0
dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1
dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0
dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1
dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0
dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1    
Global parameters
k1 kminus1 k2 kminus2
k3 kminus3 k4 kminus4
k4prime kminus4prime k6 cellsurf_vol
cyto_vol vextracellular vcellsurface vcytoplasm
navo insconc k9_basal k9
kminus9_basal kminus9 k11 kminus11
k12 kminus12 kr16a kminusr16a
k13_basal k13 kminus13 k14
kminus14 sc_pip pip3_basal k30f
k30r k31f k31r k34f
k34r1 k34r2 k34r3 k35f
k35r k36f k_ros_perm ros_perm
membrane_area k38r k38f ros_ext_conc
ros_cyto_conc sc_ros k7 kminus7a
kminus7b k8 kminus8 IRp
molec_per_fm k2psp kcat82 Km82
k_irs1_basal_syn k_irs1_basal_degr k_irs1_polyserp_degr kcat51
kcat52 Km51 Km52 k42f
k42r k43f k43r alpha_ox
k32f k32r rosconc by_jnk_phos_factor
by_ikk_phos_factor      
Reactions (367)
 
 R1f [Ins] + [InR] → [Ins_InR];   {InR} , {Ins}
 
 R1r [Ins_InR] → [InR] + [Ins];   {Ins_InR}
 
 R2 [Ins_InR] → [Ins_InR_P];   {Ins_InR}
 
 R3f [Ins] + [Ins_InR_P] → [Ins_2_InR_P];   {Ins} , {Ins_InR_P}
 
 R3r [Ins_2_InR_P] → [Ins_InR_P] + [Ins];   {Ins_2_InR_P}
 
 R4 [Ins_InR_P] → [InR];   {PTP1B} , {Ins_InR_P} , {PTP1B}
 
 R5f [InR] → [cytoplasm_InR];   {InR}
 
 R5r [cytoplasm_InR] → [InR];   {cytoplasm_InR}
 
 R6f [Ins_2_InR_P] → [cytoplasm_Ins_2_InR_P];   {Ins_2_InR_P}
 
 R6r [cytoplasm_Ins_2_InR_P] → [Ins_2_InR_P];   {cytoplasm_Ins_2_InR_P}
 
 R7f [Ins_InR_P] → [cytoplasm_Ins_InR_P];   {Ins_InR_P}
 
 R7r [cytoplasm_Ins_InR_P] → [Ins_InR_P];   {cytoplasm_Ins_InR_P}
 
 R10 [cytoplasm_Ins_2_InR_P] → [cytoplasm_InR];   {PTP1B} , {PTP1B} , {cytoplasm_Ins_2_InR_P}
 
 R11 [cytoplasm_Ins_InR_P] → [cytoplasm_InR];   {PTP1B} , {PTP1B} , {cytoplasm_Ins_InR_P}
 
 R14f [PIP2] → [PI345P3];   {IRS1_TyrP_PI3K} , {IRS1_TyrP_PI3K} , {PIP2}
 
 R14r [PI345P3] → [PIP2];   {PTEN} , {PI345P3} , {PTEN}
 
 R16f [Akt] → [Akt_P2];   {PI345P3} , {Akt} , {PI345P3}
 
 R16r [Akt_P2] → [Akt];   {PP2A} , {Akt_P2} , {PP2A}
 
 R16a_f [AS160] → [AS160_P];   {Akt_P2} , {AS160} , {Akt_P2}
 
 R16a_r [AS160_P] → [AS160];   {PP2A} , {AS160_P} , {PP2A}
 
 R17f [PKC] → [PKC_P];   {PI345P3} , {PI345P3} , {PKC}
 
 R17r [PKC_P] → [PKC];   {PP2A} , {PKC_P} , {PP2A}
 
 R20f [cytoplasm_GLUT4] → [cellsurface_GLUT4];   {AS160_P} , {AS160_P} , {cytoplasm_GLUT4}
 
 R20r [cellsurface_GLUT4] → [cytoplasm_GLUT4];   {cellsurface_GLUT4}
 
 R30f [PTP1B] + [ROS] → [PTP1B_ox] + [ROS];   {PTP1B} , {ROS}
 
 R30r [PTP1B_ox] + [GSH] → [PTP1B] + [GSH];   {GSH} , {PTP1B_ox}
 
 R31f [PTEN] + [ROS] → [PTEN_ox] + [ROS];   {PTEN} , {ROS}
 
 R31r [PTEN_ox] + [GSH] → [PTEN] + [GSH];   {GSH} , {PTEN_ox}
 
 R34f [NOX_inact] + [Ins] → [NOX] + [Ins];   {Ins} , {NOX_inact}
 
 R34r1 [NOX] → [NOX_deact];   {NOX}
 
 R34r2 [NOX] → [NOX_inact];   {NOX}
 
 R34r3 [NOX_deact] → [NOX_inact];   {NOX_deact}
 
 R35f [NOX] → [ROS] + [NOX];   {NOX}
 
 R35r [ROS] + [cytoplasm_SOD2] → [cytoplasm_SOD2];   {ROS} , {cytoplasm_SOD2}
 
 R36f [Mt] → [Mt] + [ROS];   {Mt}
 
 R37f [extracellular_ROS] → [ROS];   {extracellular_ROS}
 
 R37r [ROS] → [extracellular_ROS];   {ROS}
 
 R38f [GSH] → [GSSG];   {ROS} , {GSH} , {ROS}
 
 R38r [GSSG] → [GSH];   {GSSG}
 
 R12f [IRS1] → [IRS1_TyrP];   {Ins_2_InR_P} , {Ins_InR_P} , {IRS1} , {Ins_2_InR_P} , {Ins_InR_P}
 
 R12r [IRS1_TyrP] → [IRS1];   {PTP1B} , {IRS1_TyrP} , {PTP1B}
 
 R12_a_f [IRS1] → [IRS1_PolySerP];   {PKC_P} , {IRS1} , {PKC_P}
 
 R12_a_r [IRS1_PolySerP] → [IRS1];   {PP2A} , {IRS1_PolySerP} , {PP2A}
 
 R12_b_f [IRS1_TyrP] → [IRS1_TyrP_PolySerP];   {PKC_P} , {IRS1_TyrP} , {PKC_P}
 
 R12_b_r [IRS1_TyrP_PolySerP] → [IRS1_TyrP];   {PP2A} , {IRS1_TyrP_PolySerP} , {PP2A}
 
 R13f [PI3K] + [IRS1_TyrP] → [IRS1_TyrP_PI3K];   {IRS1_TyrP} , {PI3K}
 
 R13r [IRS1_TyrP_PI3K] → [PI3K] + [IRS1_TyrP];   {IRS1_TyrP_PI3K}
 
 R50f [NULL] → [IRS1];  
 
 R50r1 [IRS1] → [NULL];   {IRS1}
 
 R50r2 [IRS1_TyrP] → [NULL];   {IRS1_TyrP}
 
 R50r3 [IRS1_PolySerP] → [NULL];   {IRS1_PolySerP}
 
 R50r4 [IRS1_TyrP_PolySerP] → [NULL];   {IRS1_TyrP_PolySerP}
 
 R51f [IRS1] → [IRS1_PolySerP];   {IKK_P} , {IKK_P} , {IRS1}
 
 R52f [IRS1] → [IRS1_PolySerP];   {JNK_P} , {IRS1} , {JNK_P}
 
 R42f [JNK] → [JNK_P];   {ROS} , {JNK} , {ROS}
 
 R42r [JNK_P] → [JNK];   {DUSP} , {DUSP} , {JNK_P}
 
 R43f [IKK] → [IKK_P];   {ROS} , {IKK} , {ROS}
 
 R43r [IKK_P] → [IKK];   {DUSP} , {DUSP} , {IKK_P}
 
 R32f [DUSP] + [ROS] → [DUSP_ox] + [ROS];   {DUSP} , {ROS}
 
 R32r [DUSP_ox] + [GSH] → [DUSP] + [GSH];   {DUSP_ox} , {GSH}
 
 Synthesis [null] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0];   {E2F1} , {E2F1}
 
 transport cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0];   {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0];   {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0];   {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 transport dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0];   {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 transport cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1];   {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1];   {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 transport nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1] → [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1];   {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 transport dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1];   {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 transport cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0];   {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0];   {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0];   {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 transport dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0];   {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 transport cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1];   {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1] → [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1];   {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 transport nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1] → [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1];   {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 transport dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1];   {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 transport cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0];   {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0];   {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0];   {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 transport dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0];   {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 transport cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1];   {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1] → [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1];   {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 transport nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1] → [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1];   {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 transport dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1];   {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 transport cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0];   {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0];   {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0];   {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 transport dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0];   {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 transport cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1];   {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1] → [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1];   {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 transport nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1] → [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1];   {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 transport dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1];   {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 transport cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0];   {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0];   {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0];   {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 transport dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0];   {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 transport cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1];   {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1];   {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 transport nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1];   {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 transport dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1];   {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 transport cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0];   {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0];   {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0];   {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 transport dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0];   {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 transport cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1];   {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1];   {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 transport nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1];   {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 transport dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1];   {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 transport cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0];   {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0];   {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0];   {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 transport dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0];   {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 transport cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1];   {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1];   {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 transport nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1];   {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 transport dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1];   {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 transport cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0];   {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0];   {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0];   {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 transport dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0];   {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 transport cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1];   {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1];   {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 transport nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1];   {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 transport dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1];   {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2 [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0];   {Akt_P2} , {Akt_P2} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2 [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0];   {Akt_P2} , {Akt_P2} , {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by Akt_P2 [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0];   {Akt_P2} , {Akt_P2} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2 [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1];   {Akt_P2} , {Akt_P2} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2 [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1];   {Akt_P2} , {Akt_P2} , {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by Akt_P2 [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1];   {Akt_P2} , {Akt_P2} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2 [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0];   {Akt_P2} , {Akt_P2} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2 [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0];   {Akt_P2} , {Akt_P2} , {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by Akt_P2 [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0];   {Akt_P2} , {Akt_P2} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by Akt_P2 [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1];   {Akt_P2} , {Akt_P2} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by Akt_P2 [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1];   {Akt_P2} , {Akt_P2} , {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by Akt_P2 [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1];   {Akt_P2} , {Akt_P2} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by Akt_P2 [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0];   {Akt_P2} , {Akt_P2} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by Akt_P2 [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0];   {Akt_P2} , {Akt_P2} , {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by Akt_P2 [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0];   {Akt_P2} , {Akt_P2} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2 [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1];   {Akt_P2} , {Akt_P2} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2 [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1];   {Akt_P2} , {Akt_P2} , {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by Akt_P2 [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1];   {Akt_P2} , {Akt_P2} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2 [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0];   {Akt_P2} , {Akt_P2} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2 [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0];   {Akt_P2} , {Akt_P2} , {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by Akt_P2 [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0];   {Akt_P2} , {Akt_P2} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2 [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1];   {Akt_P2} , {Akt_P2} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2 [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1];   {Akt_P2} , {Akt_P2} , {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by Akt_P2 [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1];   {Akt_P2} , {Akt_P2} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by SGK [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0];   {SGK} , {SGK} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by SGK [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0];   {SGK} , {SGK} , {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by SGK [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0];   {SGK} , {SGK} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1];   {SGK} , {SGK} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1];   {SGK} , {SGK} , {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by SGK [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1];   {SGK} , {SGK} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0];   {SGK} , {SGK} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0];   {SGK} , {SGK} , {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by SGK [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0];   {SGK} , {SGK} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1];   {SGK} , {SGK} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1];   {SGK} , {SGK} , {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by SGK [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1];   {SGK} , {SGK} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by SGK [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0];   {SGK} , {SGK} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by SGK [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0];   {SGK} , {SGK} , {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by SGK [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0];   {SGK} , {SGK} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by SGK [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1];   {SGK} , {SGK} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by SGK [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1];   {SGK} , {SGK} , {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by SGK [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1];   {SGK} , {SGK} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0];   {SGK} , {SGK} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0];   {SGK} , {SGK} , {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by SGK [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0];   {SGK} , {SGK} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by SGK [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1];   {SGK} , {SGK} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by SGK [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1];   {SGK} , {SGK} , {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by SGK [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1];   {SGK} , {SGK} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1] → [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1] → [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1] → [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1] → [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1] → [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1] → [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1] → [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0];   {IKK_P} , {IKK_P} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0];   {IKK_P} , {IKK_P} , {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by IKK_P [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0];   {IKK_P} , {IKK_P} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1] → [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1];   {IKK_P} , {IKK_P} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1];   {IKK_P} , {IKK_P} , {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by IKK_P [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1] → [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1];   {IKK_P} , {IKK_P} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0];   {IKK_P} , {IKK_P} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0];   {IKK_P} , {IKK_P} , {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by IKK_P [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0];   {IKK_P} , {IKK_P} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by IKK_P [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1] → [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1];   {IKK_P} , {IKK_P} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by IKK_P [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1];   {IKK_P} , {IKK_P} , {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by IKK_P [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1] → [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1];   {IKK_P} , {IKK_P} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1] → [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 by PP2A [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1] → [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by PP2A [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1] → [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0];   {IKK_P} , {IKK_P} , {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0];   {IKK_P} , {IKK_P} , {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by IKK_P [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0];   {IKK_P} , {IKK_P} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1];   {IKK_P} , {IKK_P} , {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1];   {IKK_P} , {IKK_P} , {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by IKK_P [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1];   {IKK_P} , {IKK_P} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by IKK_P [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0];   {IKK_P} , {IKK_P} , {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by IKK_P [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0];   {IKK_P} , {IKK_P} , {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by IKK_P [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0];   {IKK_P} , {IKK_P} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1];   {IKK_P} , {IKK_P} , {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1];   {IKK_P} , {IKK_P} , {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by IKK_P [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1];   {IKK_P} , {IKK_P} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0];   {JNK_P} , {JNK_P} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0];   {JNK_P} , {JNK_P} , {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 by JNK_P [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0];   {JNK_P} , {JNK_P} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1] → [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1];   {JNK_P} , {JNK_P} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1];   {JNK_P} , {JNK_P} , {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by JNK_P [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1] → [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1];   {JNK_P} , {JNK_P} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 by PP2A [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by PP2A [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1] → [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0];   {JNK_P} , {JNK_P} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0];   {JNK_P} , {JNK_P} , {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 by JNK_P [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0];   {JNK_P} , {JNK_P} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by JNK_P [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1] → [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1];   {JNK_P} , {JNK_P} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by JNK_P [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1];   {JNK_P} , {JNK_P} , {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by JNK_P [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1] → [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1];   {JNK_P} , {JNK_P} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 by PP2A [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1] → [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by PP2A [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1] → [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 by JNK_P [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0];   {JNK_P} , {JNK_P} , {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 by JNK_P [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0];   {JNK_P} , {JNK_P} , {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 by JNK_P [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0];   {JNK_P} , {JNK_P} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1];   {JNK_P} , {JNK_P} , {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1];   {JNK_P} , {JNK_P} , {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by JNK_P [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1];   {JNK_P} , {JNK_P} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 by PP2A [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by PP2A [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0];   {JNK_P} , {JNK_P} , {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0];   {JNK_P} , {JNK_P} , {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 by JNK_P [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0];   {JNK_P} , {JNK_P} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1];   {JNK_P} , {JNK_P} , {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1];   {JNK_P} , {JNK_P} , {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by JNK_P [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1];   {JNK_P} , {JNK_P} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by PP2A [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1];   {PP2A} , {PP2A} , {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by PP2A [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1];   {PP2A} , {PP2A} , {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by PP2A [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1];   {PP2A} , {PP2A} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 by SCF [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1];   {SCF} , {SCF} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1 by SCF [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1];   {SCF} , {SCF} , {nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 by SCF [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1];   {SCF} , {SCF} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 by SCF [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1];   {SCF} , {SCF} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1 by SCF [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1];   {SCF} , {SCF} , {nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 by SCF [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1];   {SCF} , {SCF} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1];   {SCF} , {SCF} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1];   {SCF} , {SCF} , {nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 by SCF [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1];   {SCF} , {SCF} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 by SCF [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1];   {SCF} , {SCF} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1 by SCF [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1];   {SCF} , {SCF} , {nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 by SCF [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1];   {SCF} , {SCF} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1];   {SCF} , {SCF} , {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1];   {SCF} , {SCF} , {nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 by SCF [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1];   {SCF} , {SCF} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1];   {SCF} , {SCF} , {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1];   {SCF} , {SCF} , {nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 by SCF [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1];   {SCF} , {SCF} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 by SCF [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1];   {SCF} , {SCF} , {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1 by SCF [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1];   {SCF} , {SCF} , {nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 by SCF [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1];   {SCF} , {SCF} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 conversion of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0 to cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 by SCF [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0] → [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1];   {SCF} , {SCF} , {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0 to nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1 by SCF [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0] → [nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1];   {SCF} , {SCF} , {nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 conversion of dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 to dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 by SCF [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0] → [dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1];   {SCF} , {SCF} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 degradation of cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1 [cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1] → [degr_Foxo1];   {Proteasome} , {Proteasome} , {cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 degradation of cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1 [cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1] → [degr_Foxo1];   {Proteasome} , {Proteasome} , {cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 degradation of cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1 [cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1] → [degr_Foxo1];   {Proteasome} , {Proteasome} , {cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 degradation of cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1 [cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1] → [degr_Foxo1];   {Proteasome} , {Proteasome} , {cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 degradation of cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1 [cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1] → [degr_Foxo1];   {Proteasome} , {Proteasome} , {cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 degradation of cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1 [cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1] → [degr_Foxo1];   {Proteasome} , {Proteasome} , {cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 degradation of cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1 [cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1] → [degr_Foxo1];   {Proteasome} , {Proteasome} , {cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 degradation of cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1 [cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1] → [degr_Foxo1];   {Proteasome} , {Proteasome} , {cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0}
 
 transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1} , {dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1}
 
 transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0}
 
 transcription of InR by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1} , {dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1}
 
 transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0}
 
 transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1} , {dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1}
 
 transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0}
 
 transcription of InR by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 transcription of SOD2 by dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1} , {dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1}
 
 transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0}
 
 transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1} , {dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1}
 
 transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0}
 
 transcription of InR by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1} , {dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1}
 
 transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0}
 
 transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1} , {dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1}
 
 transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0}
 
 transcription of InR by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 [null] → [nucleus_RNA_InR];   {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 transcription of SOD2 by dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1 [null] → [nucleus_RNA_SOD2];   {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1} , {dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1}
 
 basal transcription of InR [null] → [nucleus_RNA_InR];  
 
 export of InR RNA [nucleus_RNA_InR] → [cytoplasm_RNA_InR];   {nucleus_RNA_InR}
 
 cyto degr of InR RNA [cytoplasm_RNA_InR] → [null];   {cytoplasm_RNA_InR}
 
 translation of InR [null] → [cytoplasm_InR];   {cytoplasm_RNA_InR} , {cytoplasm_RNA_InR}
 
 degradation of InR protein [cytoplasm_InR] → [null];   {cytoplasm_InR}
 
 basal transcription of SOD2 [null] → [nucleus_RNA_SOD2];  
 
 export of SOD2 RNA [nucleus_RNA_SOD2] → [cytoplasm_RNA_SOD2];   {nucleus_RNA_SOD2}
 
 cyto degr of SOD2 RNA [cytoplasm_RNA_SOD2] → [null];   {cytoplasm_RNA_SOD2}
 
 translation of SOD2 [null] → [cytoplasm_SOD2];   {cytoplasm_RNA_SOD2} , {cytoplasm_RNA_SOD2}
 
 degradation of SOD2 protein [cytoplasm_SOD2] → [null];   {cytoplasm_SOD2}
 
Rules (29)
 
 Assignment Rule (name: JNK_plus_JNK_P) JNK_plus_JNK_P = (JNK*cytoplasm+JNK_P*cytoplasm)/cytoplasm
 
 Assignment Rule (name: IKK_plus_IKK_P) IKK_plus_IKK_P = (IKK*cytoplasm+IKK_P*cytoplasm)/cytoplasm
 
 Assignment Rule (name: DUSP_plus_DUSP_ox) DUSP_plus_DUSP_ox = (DUSP*cytoplasm+DUSP_ox*cytoplasm)/cytoplasm
 
 Assignment Rule (name: k_ros_perm) k_ros_perm = ros_perm*membrane_area
 
 Assignment Rule (name: insconc) insconc = Ins*extracellular/(navo*vextracellular)
 
 Assignment Rule (name: Foxo1_Pa0_tot) Foxo1_Pa0_tot = (cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1*dnabound)/extracellular
 
 Assignment Rule (name: Foxo1_Pa1_tot) Foxo1_Pa1_tot = (cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1*dnabound)/extracellular
 
 Assignment Rule (name: Foxo1_Pd0_tot) Foxo1_Pd0_tot = (cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1*dnabound)/extracellular
 
 Assignment Rule (name: Foxo1_Pd1_tot) Foxo1_Pd1_tot = (cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1*dnabound)/extracellular
 
 Assignment Rule (name: Foxo1_Pe0_tot) Foxo1_Pe0_tot = (cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1*dnabound)/extracellular
 
 Assignment Rule (name: Foxo1_Pe1_tot) Foxo1_Pe1_tot = (cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1*dnabound)/extracellular
 
 Assignment Rule (name: Foxo1_pUb0_tot) Foxo1_pUb0_tot = (cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0*dnabound)/extracellular
 
 Assignment Rule (name: Foxo1_pUb1_tot) Foxo1_pUb1_tot = (cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1*dnabound+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1*cytoplasm+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1*nucleus+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1*dnabound)/extracellular
 
 Assignment Rule (name: cytoplasm_Foxo1_tot) cytoplasm_Foxo1_tot = (cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb0*cytoplasm+cytoplasm_Foxo1_Pa0_Pd0_Pe0_pUb1*cytoplasm+cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb0*cytoplasm+cytoplasm_Foxo1_Pa0_Pd0_Pe1_pUb1*cytoplasm+cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb0*cytoplasm+cytoplasm_Foxo1_Pa0_Pd1_Pe0_pUb1*cytoplasm+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb0*cytoplasm+cytoplasm_Foxo1_Pa0_Pd1_Pe1_pUb1*cytoplasm+cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb0*cytoplasm+cytoplasm_Foxo1_Pa1_Pd0_Pe0_pUb1*cytoplasm+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb0*cytoplasm+cytoplasm_Foxo1_Pa1_Pd0_Pe1_pUb1*cytoplasm+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb0*cytoplasm+cytoplasm_Foxo1_Pa1_Pd1_Pe0_pUb1*cytoplasm+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb0*cytoplasm+cytoplasm_Foxo1_Pa1_Pd1_Pe1_pUb1*cytoplasm)/extracellular
 
 Assignment Rule (name: nucleus_Foxo1_tot) nucleus_Foxo1_tot = (nucleus_Foxo1_Pa0_Pd0_Pe0_pUb0*nucleus+nucleus_Foxo1_Pa0_Pd0_Pe0_pUb1*nucleus+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb0*nucleus+nucleus_Foxo1_Pa0_Pd0_Pe1_pUb1*nucleus+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb0*nucleus+nucleus_Foxo1_Pa0_Pd1_Pe0_pUb1*nucleus+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb0*nucleus+nucleus_Foxo1_Pa0_Pd1_Pe1_pUb1*nucleus+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb0*nucleus+nucleus_Foxo1_Pa1_Pd0_Pe0_pUb1*nucleus+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb0*nucleus+nucleus_Foxo1_Pa1_Pd0_Pe1_pUb1*nucleus+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb0*nucleus+nucleus_Foxo1_Pa1_Pd1_Pe0_pUb1*nucleus+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb0*nucleus+nucleus_Foxo1_Pa1_Pd1_Pe1_pUb1*nucleus)/extracellular
 
 Assignment Rule (name: dnabound_Foxo1_tot) dnabound_Foxo1_tot = (dnabound_Foxo1_Pa0_Pd0_Pe0_pUb0*dnabound+dnabound_Foxo1_Pa0_Pd0_Pe0_pUb1*dnabound+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb0*dnabound+dnabound_Foxo1_Pa0_Pd0_Pe1_pUb1*dnabound+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb0*dnabound+dnabound_Foxo1_Pa0_Pd1_Pe0_pUb1*dnabound+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb0*dnabound+dnabound_Foxo1_Pa0_Pd1_Pe1_pUb1*dnabound+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb0*dnabound+dnabound_Foxo1_Pa1_Pd0_Pe0_pUb1*dnabound+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb0*dnabound+dnabound_Foxo1_Pa1_Pd0_Pe1_pUb1*dnabound+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb0*dnabound+dnabound_Foxo1_Pa1_Pd1_Pe0_pUb1*dnabound+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb0*dnabound+dnabound_Foxo1_Pa1_Pd1_Pe1_pUb1*dnabound)/extracellular
 
 Assignment Rule (name: Foxo1_all) Foxo1_all = (cytoplasm_Foxo1_tot*extracellular+nucleus_Foxo1_tot*extracellular+dnabound_Foxo1_tot*extracellular)/extracellular
 
 Assignment Rule (name: ros_ext_conc) ros_ext_conc = sc_ros*extracellular_ROS*extracellular/(navo*extracellular)
 
 Assignment Rule (name: ros_cyto_conc) ros_cyto_conc = sc_ros*ROS*cytoplasm/(navo*cytoplasm)
 
 Assignment Rule (name: PTP1B_plus_PTP1B_ox) PTP1B_plus_PTP1B_ox = (PTP1B*cytoplasm+PTP1B_ox*cytoplasm)/cytoplasm
 
 Assignment Rule (name: PTEN_plus_PTEN_ox) PTEN_plus_PTEN_ox = (PTEN*cytoplasm+PTEN_ox*cytoplasm)/cytoplasm
 
 Assignment Rule (name: NOX_total) NOX_total = (NOX_inact*cytoplasm+NOX*cytoplasm+NOX_deact*cytoplasm)/cytoplasm
 
 Assignment Rule (name: IRS_total) IRS_total = (IRS1*cytoplasm+IRS1_TyrP*cytoplasm+IRS1_PolySerP*cytoplasm+IRS1_TyrP_PolySerP*cytoplasm)/cytoplasm
 
 Assignment Rule (name: InR_tot) InR_tot = (InR*cellsurface+Ins_InR*cellsurface+Ins_InR_P*cellsurface+Ins_2_InR_P*cellsurface+cytoplasm_InR*cytoplasm+cytoplasm_Ins_2_InR_P*cytoplasm+cytoplasm_Ins_InR_P*cytoplasm)/cytoplasm