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BIOMD0000000473 - Smallbone2013 - Yeast metabolic model with modular rate law, merged with Pritchard 2002

 

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Reference Publication
Publication ID: 10.1089/ind.2013.000...
Messiha HL, Kent E, Malys N, Carroll KM, Mendes P, Smallbone K.
Large-Scale Metabolic Models: From Reconstruction to Differential Equations
Industrial Biotechnology
Manchester Centre for Integrative Systems Biology and School of Computer Science, University of Manchester, Manchester Institute of Biotechnology, Manchester, UK  [more]
Model
Original Model: BIOMD0000000473.origin
Submitter: Kieran Smallbone
Submission ID: MODEL1302140005
Submission Date: 14 Feb 2013 11:01:20 UTC
Last Modification Date: 29 Apr 2014 11:47:42 UTC
Creation Date: 20 Feb 2008 10:05:10 UTC
Encoders:  Nick Juty
   Vijayalakshmi Chelliah
   Kieran Smallbone
set #1
bqbiol:hasTaxon Taxonomy Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
set #2
bqmodel:isDerivedFrom BioModels Database Pritchard2002_glycolysis
set #3
bqbiol:hasPart Gene Ontology glycolytic process
set #4
bqbiol:isVersionOf Gene Ontology metabolic process
Notes
Model
Publication ID: 10.1089/ind.2013.000... Submission Date: 14 Feb 2013 11:01:20 UTC Last Modification Date: 29 Apr 2014 11:47:42 UTC Creation Date: 20 Feb 2008 10:05:10 UTC
Mathematical expressions
Reactions
(R)-lactate:ferricytochrome-c 2-oxidoreductase (S)-lactate:ferricytochrome-c 2-oxidoreductase 1,3-beta-glucan synthase 1,6-beta-glucan synthase
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase 1-acyl-sn-gylcerol-3-phosphate acyltransferase 1-pyrroline-5-carboxylate dehydrogenase 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (NADPH) 2-aceto-2-hydroxybutanoate synthase 2-aminoadipate transaminase 2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase
2-isopropylmalate hydratase 2-isopropylmalate synthase 2-methylcitrate dehydratase 2-oxo-4-methyl-3-carboxypentanoate decarboxylation
3',5'-bisphosphate nucleotidase 3,4-dihydroxy-2-butanone-4-phosphate synthase 3-dehydroquinate dehydratase 3-dehydroquinate synthase
3-dehydrosphinganine reductase 3-isopropylmalate dehydratase 3-isopropylmalate dehydrogenase 3-phosphoshikimate 1-carboxyvinyltransferase
5'-phosphoribosylformyl glycinamidine synthetase 5,10-methylenetetrahydrofolate reductase (NADPH) 6-phosphogluconolactonase acetohydroxy acid isomeroreductase
acetolactate synthase acetyl-CoA C-acetyltransferase acetyl-Coa carboxylase acetyl-CoA hydrolase
acetylglutamate kinase acteylornithine transaminase adenosine kinase adenosylhomocysteinase
adenylate kinase adenylate kinase (GTP) adenylosuccinate lyase (AICAR) adenylosuccinate lyase
adenylosuccinate synthase adenylyl-sulfate kinase alanine glyoxylate aminotransferase alanyl-tRNA synthetase
mitochondrial alcohol dehydrogenase aldehyde dehydrogenase (acetaldehyde, NADP) aldehyde dehydrogenase (acetylaldehyde, NAD) alpha,alpha-trehalose-phosphate synthase (UDP-forming)
anthranilate phosphoribosyltransferase anthranilate synthase argininosuccinate lyase argininosuccinate synthase
arginyl-tRNA synthetase asparagine synthase (glutamine-hydrolysing) Asparaginyl-tRNA synthetase aspartate carbamoyltransferase
aspartate kinase aspartate transaminase aspartate-semialdehyde dehydrogenase Aspartyl-tRNA synthetase
ATP phosphoribosyltransferase ATP synthase ATPase, cytosolic C-14 sterol reductase
C-3 sterol dehydrogenase C-3 sterol dehydrogenase (4-methylzymosterol) C-3 sterol keto reductase (4-methylzymosterol) C-3 sterol keto reductase (zymosterol)
C-4 methyl sterol oxidase C-4 methyl sterol oxidase C-4 methyl sterol oxidase C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
C-8 sterol isomerase C-s24 sterol reductase carbamoyl-phosphate synthase (glutamine-hydrolysing) CDP-diacylglycerol synthase
ceramide-1 synthase (26C) chorismate mutase chorismate synthase cis-aconitate(3-) to isocitrate
citrate synthase citrate to cis-aconitate(3-) CTP synthase (NH3) cystathionine beta-synthase
cystathionine g-lyase cystathionine gamma-synthase cysteinyl-tRNA synthetase cytochrome P450 lanosterol 14-alpha-demethylase (NADP)
dCMP deaminase deoxyguanylate kinase (dGMP:ATP) diacylglycerol acyltransferase diacylglycerol pyrophosphate phosphatase
dihydrofolate reductase dihydroorotase dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)
dimethylallyltranstransferase dolichyl-phosphate D-mannosyltransferase dolichyl-phosphate-mannose--protein mannosyltransferase dUTP diphosphatase
enolase fatty acid synthase (n-C12:0) fatty acid synthase (n-C14:0) fatty acid synthase (n-C16:0)
fatty acid synthase (n-C18:0) fatty acid synthase (n-C24:0), lumped reaction fatty acid synthase (n-C26:0) fatty acyl-CoA synthase (n-C10:0CoA)
fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction fatty-acid--CoA ligase (decanoate) fatty-acid--CoA ligase (dodecanoate) fatty-acid--CoA ligase (n-C26:0)
fatty-acid--CoA ligase (octadecanoate) fatty-acyl-CoA synthase (n-C12:0CoA) fatty-acyl-CoA synthase (n-C14:0CoA) fatty-acyl-CoA synthase (n-C16:0CoA)
fatty-acyl-CoA synthase (n-C18:0CoA) ferrocytochrome-c:oxygen oxidoreductase ferrocytochrome-c:oxygen oxidoreductase formate-tetrahydrofolate ligase
fructose-bisphosphate aldolase fumarase geranyltranstransferase glucose 6-phosphate dehydrogenase
glucose-6-phosphate isomerase glutamate dehydrogenase (NAD) glutamine synthetase glutaminyl-tRNA synthetase
glutamyl-tRNA synthetase glyceraldehyde-3-phosphate dehydrogenase glycerol-3-phosphatase glycerol-3-phosphate dehydrogenase (NAD)
glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase glycinamide ribotide transformylase glycine cleavage system glycine hydroxymethyltransferase
glycogen (starch) synthase glycyl-tRNA synthetase GMP synthase GTP cyclohydrolase II
guanylate kinase guanylate kinase (GMP:dATP) hexokinase (D-glucose:ATP) histidinol dehydrogenase
histidinol-phosphatase histidinol-phosphate transaminase histidyl-tRNA synthetase homoacontinate hydratase
homocitrate synthase homoisocitrate dehydrogenase homoserine dehydrogenase (NADP) homoserine kinase
homoserine O-trans-acetylase hydroxyacylglutathione hydrolase hydroxymethylglutaryl CoA reductase hydroxymethylglutaryl CoA synthase
Imidazole-glycerol-3-phosphate synthase imidazoleglycerol-phosphate dehydratase IMP dehydrogenase indole-3-glycerol-phosphate synthase
inorganic diphosphatase inosine monophosphate cyclohydrolase IPC synthase isocitrate dehydrogenase (NAD+)
isocitrate dehydrogenase (NADP+), peroxisomal isocitrate lyase isoleucine transaminase isoleucyl-tRNA synthetase
isopentenyl-diphosphate D-isomerase ketol-acid reductoisomerase (2-aceto-2-hydroxybutanoate) L-alanine transaminase L-aminoadipate-semialdehyde dehydrogenase (NADPH)
L-lactaldehyde:NADP+ 1-oxidoreductase L-threonine deaminase lactaldehyde dehydrogenase lactoylglutathione lyase
lanosterol synthase leucine transaminase leucyl-tRNA synthetase lysyl-tRNA synthetase
malate dehydrogenase mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase methenyltetrahydrifikate cyclohydrolase
methionine adenosyltransferase methionine synthase methionyl-tRNA synthetase methylenetetrahydrofolate dehydrogenase (NAD)
methylenetetrahydrofolate dehydrogenase (NADP) mevalonate kinase (atp) mevalonate kinase (ctp) mevalonate pyrophoshate decarboxylase
myo-inositol 1-phosphatase myo-inositol-1-phosphate synthase N-acetyl-g-glutamyl-phosphate reductase nucleoside diphosphatase
nucleoside diphosphate kinase nucleoside-diphosphate kinase (ATP:UDP) O-acetylhomoserine (thiol)-lyase ornithine carbamoyltransferase
ornithine transacetylase orotate phosphoribosyltransferase orotidine-5'-phosphate decarboxylase phenylalanine transaminase
phenylalanyl-tRNA synthetase phopshoribosylaminoimidazole synthetase phosphatidylethanolamine methyltransferase phosphatidylinositol synthase
phosphatidylserine decarboxylase phosphatidylserine synthase phosphoadenylyl-sulfate reductase (thioredoxin) phosphoenolpyruvate carboxykinase
phosphofructokinase phosphoglucomutase phosphogluconate dehydrogenase phosphoglycerate kinase
phosphoglycerate mutase phospholipid methyltransferase phospholipid methyltransferase phosphomannomutase
phosphomevalonate kinase phosphoribosyl amino imidazolesuccinocarbozamide synthetase phosphoribosyl-AMP cyclohydrolase phosphoribosyl-ATP pyrophosphatase
phosphoribosylaminoimidazole-carboxylase phosphoribosylaminoimidazolecarboxamide formyltransferase phosphoribosylanthranilate isomerase phosphoribosylglycinamidine synthetase
phosphoribosylpyrophosphate amidotransferase phosphoribosylpyrophosphate synthetase prephenate dehydratase prephenate dehydrogenase (NADP)
prolyl-tRNA synthetase pyrroline-5-carboxylate reductase pyruvate carboxylase pyruvate decarboxylase
pyruvate kinase riboflavin synthase riboflavin synthase ribonucleoside-triphosphate reductase (ATP)
ribonucleoside-triphosphate reductase (UTP) ribonucleotide reductase ribonucleotide reductase ribonucleotide reductase
ribose-5-phosphate isomerase ribulose 5-phosphate 3-epimerase S-adenosyl-methionine delta-24-sterol-c-methyltransferase saccharopine dehydrogenase (NAD, L-lysine forming)
saccharopine dehydrogenase (NADP, L-glutamate forming) sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase serine palmitotransferase seryl-tRNA synthetase
shikimate dehydrogenase shikimate kinase squalene epoxidase (NAD) squalene synthase
steryl ester hydrolase succinate dehydrogenase (ubiquinone-6) sulfate adenylyltransferase (ADP) sulfite reductase (NADPH2)
thioredoxin reductase (NADPH) threonine aldolase threonine synthase threonyl-tRNA synthetase
thymidylate synthase transaldolase transketolase 1 transketolase 2
trehalose-phosphatase triacylglycerol lipase triose-phosphate isomerase tryptophan synthase (indoleglycerol phosphate)
tryptophanyl-tRNA synthetase tyrosine transaminase tyrosyl-tRNA synthetase UMP kinase
UTP-glucose-1-phosphate uridylyltransferase valine transaminase valyl-tRNA synthetase ammonia transport
glucose transport glycerol transport via channel phosphate transport sulfate uniport
acetaldehyde transport bicarbonate formation cholestenol delta-isomerase, lumped reaction CO2 transport
cytidylate kinase (dCMP) deoxyadenylate kinase ethanol transport methylglyoxal synthase
O2 transport pyrimidine phosphatase succinate transport growth
sedoheptulose bisphosphatase dihydroorotate dehydrogenase    
Physical entities
Compartments Species
cell (1->3)-beta-D-glucan (1->6)-beta-D-glucan (2R,3R)-2,3-dihydroxy-3-methylpentanoate
(2R,3S)-3-isopropylmalate (2S)-2-isopropyl-3-oxosuccinate (N(omega)-L-arginino)succinic acid
(R)-2,3-dihydroxy-3-methylbutanoate (R)-5-diphosphomevalonic acid (R)-5-phosphomevalonic acid
(R)-lactate (R)-mevalonate (R)-S-lactoylglutathione
(S)-2,3-epoxysqualene (S)-2-acetyl-2-hydroxybutanoate (S)-3-methyl-2-oxopentanoate
(S)-dihydroorotate (S)-lactaldehyde (S)-lactate
(S)-malate 1,3-bisphospho-D-glycerate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide 1-(5-phosphoribosyl)-5'-AMP 1-acyl-sn-glycerol 3-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate 1-phosphatidyl-1D-myo-inositol 1-pyrroline-5-carboxylate
10-formyl-THF 14-demethyllanosterol 1D-myo-inositol 1-phosphate
2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine 2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone 2-acetamido-5-oxopentanoate
2-acetyllactic acid 2-hydroxy-3-oxobutyl phosphate 2-isopropylmalate
2-isopropylmaleic acid 2-oxoadipic acid 2-oxobutanoate
2-oxoglutarate 2-phospho-D-glyceric acid farnesyl diphosphate
3'-phospho-5'-adenylyl sulfate 3-(4-hydroxyphenyl)pyruvate 3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate
3-dehydro-4-methylzymosterol 3-dehydroquinate 3-dehydroshikimate
3-hydroxy-3-methylglutaryl-CoA 3-ketosphinganine 3-methyl-2-oxobutanoate
3-phosphoglycerate 3-phosphoshikimic acid 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
4-methyl-2-oxopentanoate 4-phospho-L-aspartate 4alpha-methylzymosterol
4beta-methylzymosterol-4alpha-carboxylic acid 5'-adenylyl sulfate 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
5'-phosphoribosyl-5-aminoimidazole 5'-phosphoribosyl-N-formylglycineamide 5'-phosphoribosyl-N-formylglycineamidine
5,10-methenyl-THF 5,10-methylenetetrahydrofolate 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
5-amino-6-(5-phosphoribitylamino)uracil 5-amino-6-(D-ribitylamino)uracil 5-methyltetrahydrofolate
5-O-(1-carboxyvinyl)-3-phosphoshikimic acid 5-phospho-ribosyl-glycineamide 5-phosphoribosyl-ATP
5-phosphoribosylamine 6,7-dimethyl-8-(1-D-ribityl)lumazine 6-O-phosphono-D-glucono-1,5-lactone
6-phospho-D-gluconate 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid acetaldehyde
acetate acetoacetyl-CoA acetyl-CoA
acyl-CoA adenosine adenosine 3',5'-bismonophosphate
adenylo-succinate ADP AICAR
Ala-tRNA(Ala) alpha,alpha-trehalose 6-phosphate ammonium
AMP anthranilate Arg-tRNA(Arg)
Asn-tRNA(Asn) Asp-tRNA(Asp) ATP
bicarbonate but-1-ene-1,2,4-tricarboxylic acid carbamoyl phosphate
carbon dioxide CDP CDP-diacylglycerol
ceramide-1 (C26) cerotate chorismate
cis-aconitate citrate CMP
coenzyme A CTP Cys-tRNA(Cys)
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate D-erythrose 4-phosphate D-fructose 1,6-bisphosphate
D-fructose 6-phosphate D-glucose D-glucose 1-phosphate
D-glucose 6-phosphate D-mannose 1-phosphate D-mannose 6-phosphate
D-ribulose 5-phosphate D-xylulose 5-phosphate dADP
dAMP dATP dCDP
dCMP decanoate decanoyl-CoA
dGDP dGMP diglyceride
dihydrofolic acid dihydroxyacetone phosphate diphosphate
dolichyl D-mannosyl phosphate dolichyl phosphate dTMP
dUMP dUTP episterol
ergosta-5,7,22,24(28)-tetraen-3beta-ol ergosterol ergosterol ester
ethanol fecosterol ferricytochrome c
ferrocytochrome c formate fumarate
GDP GDP-alpha-D-mannose geranyl diphosphate
Gln-tRNA(Gln) Glu-tRNA(Glu) glutathione
Gly-tRNA(Gly) glyceraldehyde 3-phosphate glycerol
glycerol 3-phosphate glycogen glyoxylate
GMP GTP hexacosanoyl-CoA
His-tRNA(His) homocitrate homoisocitrate
hydrogen sulfide Ile-tRNA(Ile) IMP
inositol-P-ceramide A (C26) isocitrate isopentenyl diphosphate
keto-phenylpyruvate L-2-aminoadipate L-alanine
L-allysine L-arginine L-asparagine
L-aspartate L-aspartate 4-semialdehyde L-citrulline
L-cystathionine L-cysteine L-glutamate
L-glutamine L-glycine L-histidine
L-histidinol L-histidinol phosphate L-homocysteine
L-homoserine L-isoleucine L-leucine
L-lysine L-methionine L-phenylalanine
L-proline L-saccharopine L-serine
L-threonine L-tryptophan L-tyrosine
L-valine lanosterol laurate
lauroyl-CoA Leu-tRNA(Leu) lignoceric acid
Lys-tRNA(Lys) malonyl-CoA mannan
Met-tRNA(Met) methylglyoxal myo-inositol
myristate myristoyl-CoA N(2)-acetyl-L-ornithine
N-(5-phospho-beta-D-ribosyl)anthranilate N-acetyl-L-gamma-glutamyl phosphate N-acetyl-L-glutamate
N-carbamoyl-L-aspartate NAD NADH
NADP(+) NADPH O-acetyl-L-homoserine
O-phospho-L-homoserine octanoyl-CoA ornithine
orotate orotidine 5'-(dihydrogen phosphate) oxaloacetate
oxygen palmitate palmitoyl-CoA
Phe-tRNA(Phe) phosphate phosphatidate
phosphatidyl-L-serine phosphatidyl-N,N-dimethylethanolamine phosphatidyl-N-methylethanolamine
phosphatidylcholine phosphatidylethanolamine phosphoenolpyruvate
phosphoribosyl-carboxy-aminoimidazole phosphoribosyl-formamido-carboxamide prenyl diphosphate
prephenate Pro-tRNA(Pro) PRPP
pyruvate riboflavin ribose-5-phosphate
S-adenosyl-L-homocysteine S-adenosyl-L-methionine sedoheptulose 1,7-bisphosphate
sedoheptulose 7-phosphate Ser-tRNA(Ser) shikimate
sphinganine squalene stearate
stearoyl-CoA succinate sulphate
sulphite THF Thr-tRNA(Thr)
trehalose triglyceride Trp-tRNA(Trp)
Tyr-tRNA(Tyr) ubiquinol-6 ubiquinone-6
UDP UDP-D-glucose UMP
UTP Val-tRNA(Val) xanthosine-5-phosphate
zymosterol zymosterol intermediate 1a zymosterol intermediate 1b
zymosterol intermediate 1c zymosterol intermediate 2 tRNA(Ala)
tRNA(Arg) tRNA(Asn) tRNA(Asp)
tRNA(Cys) tRNA(Gln) tRNA(Glu)
tRNA(Gly) tRNA(His) tRNA(Ile)
tRNA(Leu) tRNA(Lys) tRNA(Met)
tRNA(Phe) tRNA(Pro) tRNA(Ser)
tRNA(Thr) tRNA(Trp) tRNA(Tyr)
tRNA(Val) TRX1 TRX1 disulphide
COX1 ATP8 ATP6
COB OLI1 COX2
COX3 CYS3 PMT2
CDC19 GCV3 ADE1
SCT1 ACH1 RIB1
URA7 COR1 PRS4
ILS1 ATP1 IPP1
CDS1 ATP3 FAT1
TSC3 MIS1 LYS2
TKL2 GRS1 TPS1
VMA2 ADH5 RIB7
TYR1 PGI1 PYC2
HIS7 ARO4 DUT1
RIB5 SHM1 TSC10
ILV6 LEU2 HIS4
GLK1 APA1 CHA1
CIT2 PGK1 FEN1
THR4 TRX3 ATP16
TSC13 GPD1 SLC1
PSA1 IDP1 COX9
MDH3 PMT5 PMT1
LYS21 DLD1 DLD2
LYS20 VMA1 GDH2
TRP1 GCV1 SES1
ARO3 KRS1 TPI1
TGL2 LCB2 TPS2
ARO1 YCF1 HOM2
SDH4 ADK1 LYS4
GLO2 DPP1 INM2
ATP5 TIM11 YDR341C
TRR1 TRP4 KEI1
ATP17 ADE8 GUK1
RIB3 SAM2 QCR7
URA3 RIP1 VMA3
CYC7 GLY1 VMA8
DLD3 PMI40 YND1
FAA2 PRO3 CHO1
SAH1 HOM3 HIS1
HOR2 ICL1 ARG5,6
RNR1 ALD5 ILV1
AIM10 TRP2 MET6
PRS2 ADK2 LPD1
FRS2 AGX1 SEC53
GSY1 HIS2 MET10
QCR6 HXK1 ERG26
LEU1 ERG4 TRP5
PYC1 MET13 ARO2
LYS5 COX4 COX13
ARO8 ADE5,7 GUS1
HXK2 ADH4 VMA7
GSC2 ACB1 ERG25
ADE6 PDC6 VAS1
ASN2 SKN1 CYS4
CHO2 PSD2 ERG1
RNR4 QCR9 TYS1
TDH3 ADE3 TRX2
PFK1 SOL4 ENO1
GND2 MES1 LAG1
PRS3 QCR10 ERG11
DIA4 ARG4 DED81
THR1 VMA16 PUT2
VMA10 NCP1 INM1
COX6 ERG7 GRE3
TRR2 DCD1 SOL3
ENO2 GND1 ERG9
BAT1 IMD2 FAA3
HIS6 RHR2 RNR3
THS1 LYS12 COX5B
HIS5 LYS1 RNR2
YJL045W TDH1 BNA3
ARG3 RPE1 URA2
GLG2 INO1 QCR8
ERG20 TDH2 ILV3
CYC1 OPI3 URA8
ADO1 CPA2 ATP2
STR2 MET5 HOM6
PMT4 BAT2 MET14
AUR1 LAC1 ATP7
URA6 UGP1 FBA1
YNK1 VMA5 MDH1
AAT1 PGM1 TGL1
SDH3 SDH1 GPM1
PRS1 FAS1 PXA2
TRP3 URA1 SHB17
GLG1 GPT2 MTD1
TGL4 PCK1 YEH1
DPS1 SDH2 YBT1
AAT2 ADE16 COX12
TRX1 PDC1 SHM2
FRS1 ALT1 ERG27
PDC5 SAM1 GSY2
ATP14 MET17 ACO1
FKS1 TAL1 ILV5
ADE13 SUR4 COX8
URA4 IMD3 VMA6
HMG2 GLO1 ERG6
CYB2 IMD4 HMG1
ATP18 TSL1 URA5
ERG13 STV1 ARG7
ADH3 PGM2 ILV2
ADE17 ALD2 GCV2
ERG2 PFK2 HFA1
ERG12 GUA1 ERG8
FAA4 COX7 TPS3
PPA2 URA10 PGM3
LCB1 LIP1 ADE4
TGL3 IDP3 IDH1
COX5A LEU4 PSD1
ADE12 ZWF1 YNL247W
MET2 ERG24 PHA2
CIT1 ACC1 MVD1
LYS9 ARG1 GPD2
PRS5 MET22 RIB2
ADH1 WRS1 MDH2
ARG8 RIB4 GRE2
GLO4 CYT1 CDC21
TGL5 RKI1 LEU9
ADE2 IDH2 GLN4
ALE1 HIS3 DFR1
DGA1 VPH1 CPA1
FAA1 PMT3 VMA4
ALA1 PYK2 ALD4
MET12 ERG10 ALD6
ATP4 GLR1 IDI1
PXA1 CDC60 FAS2
VMA11 FUM1 ATP15
CIT3 ATP20 HTS1
GLN1 VMA13 ARO7
TKL1 GRS2 PIS1
ASN1 KRE6 MET16
DPM1 QCR2 YER152C
beta-D-fructose 2,6-bisphosphate    
extracellular acetaldehyde ammonium carbon dioxide
D-glucose ethanol glycerol
oxygen phosphate succinate
sulphate    
Reactions (298)
 
 (R)-lactate:ferricytochrome-c 2-oxidoreductase [(R)-lactate] + 2.0 × [ferricytochrome c] ↔ 2.0 × [ferrocytochrome c] + [pyruvate];   {DLD1} , {DLD3} , {CYC7} , {CYC1} , {DLD2} , {(R)-lactate} , {ferricytochrome c} , {ferrocytochrome c} , {pyruvate}
 
 (S)-lactate:ferricytochrome-c 2-oxidoreductase [(S)-lactate] + 2.0 × [ferricytochrome c] ↔ 2.0 × [ferrocytochrome c] + [pyruvate];   {CYB2} , {CYC1} , {CYC7} , {(S)-lactate} , {ferricytochrome c} , {ferrocytochrome c} , {pyruvate}
 
 1,3-beta-glucan synthase [UDP-D-glucose] ↔ [(1->3)-beta-D-glucan] + [UDP];   {FKS1} , {GSC2} , {UDP-D-glucose} , {(1->3)-beta-D-glucan} , {UDP}
 
 1,6-beta-glucan synthase [UDP-D-glucose] ↔ [(1->6)-beta-D-glucan] + [UDP];   {KRE6} , {SKN1} , {UDP-D-glucose} , {(1->6)-beta-D-glucan} , {UDP}
 
 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase [1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide] ↔ [5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide];   {HIS6} , {1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide} , {5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide}
 
 1-acyl-sn-gylcerol-3-phosphate acyltransferase [1-acyl-sn-glycerol 3-phosphate] + [acyl-CoA] ↔ [coenzyme A] + [phosphatidate];   {ALE1} , {SLC1} , {FEN1} , {1-acyl-sn-glycerol 3-phosphate} , {acyl-CoA} , {coenzyme A} , {phosphatidate}
 
 1-pyrroline-5-carboxylate dehydrogenase [L-glutamate] + [NADH] ↔ [1-pyrroline-5-carboxylate] + [NAD];   {PUT2} , {L-glutamate} , {NADH} , {1-pyrroline-5-carboxylate} , {NAD}
 
 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase [2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone] ↔ [5-amino-6-(5-phosphoribitylamino)uracil] + [ammonium];   {RIB2} , {2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone} , {5-amino-6-(5-phosphoribitylamino)uracil} , {ammonium}
 
 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (NADPH) [2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine] + [NADPH] ↔ [2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone] + [NADP(+)];   {RIB7} , {2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine} , {NADPH} , {2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone} , {NADP(+)}
 
 2-aceto-2-hydroxybutanoate synthase [2-oxobutanoate] + [pyruvate] ↔ [(S)-2-acetyl-2-hydroxybutanoate] + [carbon dioxide];   {ILV2} , {ILV6} , {2-oxobutanoate} , {pyruvate} , {(S)-2-acetyl-2-hydroxybutanoate} , {carbon dioxide}
 
 2-aminoadipate transaminase [2-oxoadipic acid] + [L-glutamate] ↔ [2-oxoglutarate] + [L-2-aminoadipate];   {ARO8} , {BNA3} , {YER152C} , {2-oxoadipic acid} , {L-glutamate} , {2-oxoglutarate} , {L-2-aminoadipate}
 
 2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase [D-erythrose 4-phosphate] + [phosphoenolpyruvate] ↔ [7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid] + [phosphate];   {ARO3} , {ARO4} , {D-erythrose 4-phosphate} , {phosphoenolpyruvate} , {7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid} , {phosphate}
 
 2-isopropylmalate hydratase [2-isopropylmalate] ↔ [2-isopropylmaleic acid];   {LEU1} , {2-isopropylmalate} , {2-isopropylmaleic acid}
 
 2-isopropylmalate synthase [3-methyl-2-oxobutanoate] + [acetyl-CoA] ↔ [2-isopropylmalate] + [coenzyme A];   {LEU4} , {LEU9} , {3-methyl-2-oxobutanoate} , {acetyl-CoA} , {2-isopropylmalate} , {coenzyme A}
 
 2-methylcitrate dehydratase [homocitrate] ↔ [but-1-ene-1,2,4-tricarboxylic acid];   {LYS4} , {homocitrate} , {but-1-ene-1,2,4-tricarboxylic acid}
 
 2-oxo-4-methyl-3-carboxypentanoate decarboxylation [(2S)-2-isopropyl-3-oxosuccinate] ↔ [4-methyl-2-oxopentanoate] + [carbon dioxide];   {BAT2} , {BAT1} , {(2S)-2-isopropyl-3-oxosuccinate} , {4-methyl-2-oxopentanoate} , {carbon dioxide}
 
 3',5'-bisphosphate nucleotidase [adenosine 3',5'-bismonophosphate] ↔ [AMP] + [phosphate];   {MET22} , {adenosine 3',5'-bismonophosphate} , {AMP} , {phosphate}
 
 3,4-dihydroxy-2-butanone-4-phosphate synthase [D-ribulose 5-phosphate] ↔ [2-hydroxy-3-oxobutyl phosphate] + [formate];   {RIB3} , {D-ribulose 5-phosphate} , {2-hydroxy-3-oxobutyl phosphate} , {formate}
 
 3-dehydroquinate dehydratase [3-dehydroquinate] ↔ [3-dehydroshikimate];   {ARO1} , {3-dehydroquinate} , {3-dehydroshikimate}
 
 3-dehydroquinate synthase [7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid] ↔ [3-dehydroquinate] + [phosphate];   {ARO1} , {7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid} , {3-dehydroquinate} , {phosphate}
 
 3-dehydrosphinganine reductase [3-ketosphinganine] + [NADPH] ↔ [NADP(+)] + [sphinganine];   {TSC10} , {3-ketosphinganine} , {NADPH} , {NADP(+)} , {sphinganine}
 
 3-isopropylmalate dehydratase [2-isopropylmaleic acid] ↔ [(2R,3S)-3-isopropylmalate];   {LEU1} , {2-isopropylmaleic acid} , {(2R,3S)-3-isopropylmalate}
 
 3-isopropylmalate dehydrogenase [(2R,3S)-3-isopropylmalate] + [NAD] ↔ [(2S)-2-isopropyl-3-oxosuccinate] + [NADH];   {LEU2} , {(2R,3S)-3-isopropylmalate} , {NAD} , {(2S)-2-isopropyl-3-oxosuccinate} , {NADH}
 
 3-phosphoshikimate 1-carboxyvinyltransferase [3-phosphoshikimic acid] + [phosphoenolpyruvate] ↔ [5-O-(1-carboxyvinyl)-3-phosphoshikimic acid] + [phosphate];   {ARO1} , {3-phosphoshikimic acid} , {phosphoenolpyruvate} , {5-O-(1-carboxyvinyl)-3-phosphoshikimic acid} , {phosphate}
 
 5'-phosphoribosylformyl glycinamidine synthetase [5'-phosphoribosyl-N-formylglycineamide] + [ATP] + [L-glutamine] ↔ [5'-phosphoribosyl-N-formylglycineamidine] + [ADP] + [L-glutamate] + [phosphate];   {ADE6} , {5'-phosphoribosyl-N-formylglycineamide} , {ATP} , {L-glutamine} , {5'-phosphoribosyl-N-formylglycineamidine} , {ADP} , {L-glutamate} , {phosphate}
 
 5,10-methylenetetrahydrofolate reductase (NADPH) [5,10-methylenetetrahydrofolate] + [NADPH] ↔ [5-methyltetrahydrofolate] + [NADP(+)];   {MET13} , {MET12} , {5,10-methylenetetrahydrofolate} , {NADPH} , {5-methyltetrahydrofolate} , {NADP(+)}
 
 6-phosphogluconolactonase [6-O-phosphono-D-glucono-1,5-lactone] ↔ [6-phospho-D-gluconate];   {SOL3} , {SOL4} , {6-O-phosphono-D-glucono-1,5-lactone} , {6-phospho-D-gluconate}
 
 acetohydroxy acid isomeroreductase [2-acetyllactic acid] + [NADPH] ↔ [(R)-2,3-dihydroxy-3-methylbutanoate] + [NADP(+)];   {ILV5} , {2-acetyllactic acid} , {NADPH} , {(R)-2,3-dihydroxy-3-methylbutanoate} , {NADP(+)}
 
 acetolactate synthase 2.0 × [pyruvate] ↔ [2-acetyllactic acid] + [carbon dioxide];   {ILV2} , {ILV6} , {pyruvate} , {2-acetyllactic acid} , {carbon dioxide}
 
 acetyl-CoA C-acetyltransferase 2.0 × [acetyl-CoA] ↔ [acetoacetyl-CoA] + [coenzyme A];   {ERG10} , {acetyl-CoA} , {acetoacetyl-CoA} , {coenzyme A}
 
 acetyl-Coa carboxylase [acetyl-CoA] + [ATP] + [bicarbonate] ↔ [ADP] + [malonyl-CoA] + [phosphate];   {HFA1} , {ACC1} , {acetyl-CoA} , {ATP} , {bicarbonate} , {ADP} , {malonyl-CoA} , {phosphate}
 
 acetyl-CoA hydrolase [acetate] + [coenzyme A] ↔ [acetyl-CoA];   {ACH1} , {acetate} , {coenzyme A} , {acetyl-CoA}
 
 acetylglutamate kinase [ATP] + [N-acetyl-L-glutamate] ↔ [ADP] + [N-acetyl-L-gamma-glutamyl phosphate];   {ARG5,6} , {ATP} , {N-acetyl-L-glutamate} , {ADP} , {N-acetyl-L-gamma-glutamyl phosphate}
 
 acteylornithine transaminase [2-acetamido-5-oxopentanoate] + [L-glutamate] ↔ [2-oxoglutarate] + [N(2)-acetyl-L-ornithine];   {ARG8} , {2-acetamido-5-oxopentanoate} , {L-glutamate} , {2-oxoglutarate} , {N(2)-acetyl-L-ornithine}
 
 adenosine kinase [adenosine] + [ATP] ↔ [ADP] + [AMP];   {ADO1} , {adenosine} , {ATP} , {ADP} , {AMP}
 
 adenosylhomocysteinase [S-adenosyl-L-homocysteine] ↔ [adenosine] + [L-homocysteine];   {SAH1} , {S-adenosyl-L-homocysteine} , {adenosine} , {L-homocysteine}
 
 adenylate kinase 2.0 × [ADP] ↔ [AMP] + [ATP];   {ADK1} , {ADK2} , {ADP} , {AMP} , {ATP}
 
 adenylate kinase (GTP) [AMP] + [GTP] ↔ [ADP] + [GDP];   {ADK2} , {AMP} , {GTP} , {ADP} , {GDP}
 
 adenylosuccinate lyase (AICAR) [5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole] ↔ [AICAR] + [fumarate];   {ADE13} , {5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole} , {AICAR} , {fumarate}
 
 adenylosuccinate lyase [adenylo-succinate] ↔ [AMP] + [fumarate];   {ADE13} , {adenylo-succinate} , {AMP} , {fumarate}
 
 adenylosuccinate synthase [GTP] + [IMP] + [L-aspartate] ↔ [adenylo-succinate] + [GDP] + [phosphate];   {ADE12} , {GTP} , {IMP} , {L-aspartate} , {adenylo-succinate} , {GDP} , {phosphate}
 
 adenylyl-sulfate kinase [5'-adenylyl sulfate] + [ATP] ↔ [3'-phospho-5'-adenylyl sulfate] + [ADP];   {MET14} , {5'-adenylyl sulfate} , {ATP} , {3'-phospho-5'-adenylyl sulfate} , {ADP}
 
 alanine glyoxylate aminotransferase [glyoxylate] + [L-alanine] ↔ [L-glycine] + [pyruvate];   {AGX1} , {glyoxylate} , {L-alanine} , {L-glycine} , {pyruvate}
 
 alanyl-tRNA synthetase [ATP] + [L-alanine] + [tRNA(Ala)] ↔ [Ala-tRNA(Ala)] + [AMP] + [diphosphate];   {ALA1} , {ATP} , {L-alanine} , {tRNA(Ala)} , {Ala-tRNA(Ala)} , {AMP} , {diphosphate}
 
 mitochondrial alcohol dehydrogenase [acetaldehyde] + [NADH] ↔ [ethanol] + [NAD];   {ADH3} , {ADH4} , {ADH5} , {ADH1} , {acetaldehyde} , {NADH} , {ethanol} , {NAD}
 
 aldehyde dehydrogenase (acetaldehyde, NADP) [acetaldehyde] + [NADP(+)] ↔ [acetate] + [NADPH];   {ALD6} , {ALD4} , {ALD5} , {acetaldehyde} , {NADP(+)} , {acetate} , {NADPH}
 
 aldehyde dehydrogenase (acetylaldehyde, NAD) [acetaldehyde] + [NAD] ↔ [acetate] + [NADH];   {ALD4} , {ALD2} , {acetaldehyde} , {NAD} , {acetate} , {NADH}
 
 alpha,alpha-trehalose-phosphate synthase (UDP-forming) [D-glucose 6-phosphate] + [UDP-D-glucose] ↔ [alpha,alpha-trehalose 6-phosphate] + [UDP];   {TSL1} , {TPS1} , {TPS2} , {TPS3} , {D-glucose 6-phosphate} , {UDP-D-glucose} , {alpha,alpha-trehalose 6-phosphate} , {UDP}
 
 anthranilate phosphoribosyltransferase [anthranilate] + [PRPP] ↔ [diphosphate] + [N-(5-phospho-beta-D-ribosyl)anthranilate];   {TRP4} , {anthranilate} , {PRPP} , {diphosphate} , {N-(5-phospho-beta-D-ribosyl)anthranilate}
 
 anthranilate synthase [chorismate] + [L-glutamine] ↔ [anthranilate] + [L-glutamate] + [pyruvate];   {TRP2} , {TRP3} , {chorismate} , {L-glutamine} , {anthranilate} , {L-glutamate} , {pyruvate}
 
 argininosuccinate lyase [(N(omega)-L-arginino)succinic acid] ↔ [fumarate] + [L-arginine];   {ARG4} , {(N(omega)-L-arginino)succinic acid} , {fumarate} , {L-arginine}
 
 argininosuccinate synthase [ATP] + [L-aspartate] + [L-citrulline] ↔ [(N(omega)-L-arginino)succinic acid] + [AMP] + [diphosphate];   {ARG1} , {ATP} , {L-aspartate} , {L-citrulline} , {(N(omega)-L-arginino)succinic acid} , {AMP} , {diphosphate}
 
 arginyl-tRNA synthetase [ATP] + [L-arginine] + [tRNA(Arg)] ↔ [AMP] + [Arg-tRNA(Arg)] + [diphosphate];   {YDR341C} , {ATP} , {L-arginine} , {tRNA(Arg)} , {AMP} , {Arg-tRNA(Arg)} , {diphosphate}
 
 asparagine synthase (glutamine-hydrolysing) [ATP] + [L-aspartate] + [L-glutamine] ↔ [AMP] + [diphosphate] + [L-asparagine] + [L-glutamate];   {ASN1} , {ASN2} , {ATP} , {L-aspartate} , {L-glutamine} , {AMP} , {diphosphate} , {L-asparagine} , {L-glutamate}
 
 Asparaginyl-tRNA synthetase [ATP] + [L-asparagine] + [tRNA(Asn)] ↔ [AMP] + [Asn-tRNA(Asn)] + [diphosphate];   {DED81} , {ATP} , {L-asparagine} , {tRNA(Asn)} , {AMP} , {Asn-tRNA(Asn)} , {diphosphate}
 
 aspartate carbamoyltransferase [carbamoyl phosphate] + [L-aspartate] ↔ [N-carbamoyl-L-aspartate] + [phosphate];   {URA2} , {carbamoyl phosphate} , {L-aspartate} , {N-carbamoyl-L-aspartate} , {phosphate}
 
 aspartate kinase [ATP] + [L-aspartate] ↔ [4-phospho-L-aspartate] + [ADP];   {HOM3} , {ATP} , {L-aspartate} , {4-phospho-L-aspartate} , {ADP}
 
 aspartate transaminase [L-glutamate] + [oxaloacetate] ↔ [2-oxoglutarate] + [L-aspartate];   {AAT2} , {AAT1} , {L-glutamate} , {oxaloacetate} , {2-oxoglutarate} , {L-aspartate}
 
 aspartate-semialdehyde dehydrogenase [4-phospho-L-aspartate] + [NADPH] ↔ [L-aspartate 4-semialdehyde] + [NADP(+)] + [phosphate];   {HOM2} , {4-phospho-L-aspartate} , {NADPH} , {L-aspartate 4-semialdehyde} , {NADP(+)} , {phosphate}
 
 Aspartyl-tRNA synthetase [ATP] + [L-aspartate] + [tRNA(Asp)] ↔ [AMP] + [Asp-tRNA(Asp)] + [diphosphate];   {DPS1} , {ATP} , {L-aspartate} , {tRNA(Asp)} , {AMP} , {Asp-tRNA(Asp)} , {diphosphate}
 
 ATP phosphoribosyltransferase [ATP] + [PRPP] ↔ [5-phosphoribosyl-ATP] + [diphosphate];   {HIS1} , {ATP} , {PRPP} , {5-phosphoribosyl-ATP} , {diphosphate}
 
 ATP synthase [ADP] + [phosphate] ↔ [ATP];   {ATP20} , {ATP15} , {OLI1} , {ATP1} , {ATP5} , {ATP6} , {ATP14} , {ATP8} , {ATP3} , {ATP17} , {ATP18} , {TIM11} , {ATP2} , {ATP7} , {ATP16} , {ATP4} , {ADP} , {phosphate} , {ATP}
 
 ATPase, cytosolic [ATP] ↔ [ADP] + [phosphate];   {STV1} , {VMA5} , {VMA10} , {VMA8} , {VMA13} , {VMA1} , {VMA4} , {VMA7} , {VMA3} , {VMA6} , {VMA11} , {VMA2} , {VMA16} , {YCF1} , {YBT1} , {VMA5} , {VMA10} , {VMA8} , {VMA13} , {VMA1} , {VMA4} , {VMA7} , {VMA3} , {VMA6} , {VPH1} , {VMA11} , {VMA2} , {VMA16} , {PXA2} , {PXA1} , {ATP}
 
 C-14 sterol reductase [4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol] + [NADPH] ↔ [14-demethyllanosterol] + [NADP(+)];   {ERG24} , {4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol} , {NADPH} , {14-demethyllanosterol} , {NADP(+)}
 
 C-3 sterol dehydrogenase [NADP(+)] + [zymosterol intermediate 1c] ↔ [carbon dioxide] + [NADPH] + [zymosterol intermediate 2];   {ERG26} , {NADP(+)} , {zymosterol intermediate 1c} , {carbon dioxide} , {NADPH} , {zymosterol intermediate 2}
 
 C-3 sterol dehydrogenase (4-methylzymosterol) [4beta-methylzymosterol-4alpha-carboxylic acid] + [NAD] ↔ [3-dehydro-4-methylzymosterol] + [carbon dioxide] + [NADH];   {ERG26} , {4beta-methylzymosterol-4alpha-carboxylic acid} , {NAD} , {3-dehydro-4-methylzymosterol} , {carbon dioxide} , {NADH}
 
 C-3 sterol keto reductase (4-methylzymosterol) [3-dehydro-4-methylzymosterol] + [NADPH] ↔ [4alpha-methylzymosterol] + [NADP(+)];   {ERG27} , {3-dehydro-4-methylzymosterol} , {NADPH} , {4alpha-methylzymosterol} , {NADP(+)}
 
 C-3 sterol keto reductase (zymosterol) [NADPH] + [zymosterol intermediate 2] ↔ [NADP(+)] + [zymosterol];   {ERG27} , {NADPH} , {zymosterol intermediate 2} , {NADP(+)} , {zymosterol}
 
 C-4 methyl sterol oxidase [4alpha-methylzymosterol] + [NADPH] + [oxygen] ↔ [NADP(+)] + [zymosterol intermediate 1a];   {ERG25} , {4alpha-methylzymosterol} , {NADPH} , {oxygen} , {NADP(+)} , {zymosterol intermediate 1a}
 
 C-4 methyl sterol oxidase [NADPH] + [oxygen] + [zymosterol intermediate 1a] ↔ [NADP(+)] + [zymosterol intermediate 1b];   {ERG25} , {NADPH} , {oxygen} , {zymosterol intermediate 1a} , {NADP(+)} , {zymosterol intermediate 1b}
 
 C-4 methyl sterol oxidase [NADPH] + [oxygen] + [zymosterol intermediate 1b] ↔ [NADP(+)] + [zymosterol intermediate 1c];   {ERG25} , {NADPH} , {oxygen} , {zymosterol intermediate 1b} , {NADP(+)} , {zymosterol intermediate 1c}
 
 C-4 sterol methyl oxidase (4,4-dimethylzymosterol) [14-demethyllanosterol] + 3.0 × [NADPH] + 3.0 × [oxygen] ↔ [4beta-methylzymosterol-4alpha-carboxylic acid] + 3.0 × [NADP(+)];   {ERG25} , {14-demethyllanosterol} , {NADPH} , {oxygen} , {4beta-methylzymosterol-4alpha-carboxylic acid} , {NADP(+)}
 
 C-8 sterol isomerase [fecosterol] ↔ [episterol];   {ERG2} , {fecosterol} , {episterol}
 
 C-s24 sterol reductase [ergosta-5,7,22,24(28)-tetraen-3beta-ol] + [NADPH] ↔ [ergosterol] + [NADP(+)];   {ERG4} , {ergosta-5,7,22,24(28)-tetraen-3beta-ol} , {NADPH} , {ergosterol} , {NADP(+)}
 
 carbamoyl-phosphate synthase (glutamine-hydrolysing) 2.0 × [ATP] + [bicarbonate] + [L-glutamine] ↔ 2.0 × [ADP] + [carbamoyl phosphate] + [L-glutamate] + [phosphate];   {URA2} , {CPA2} , {CPA1} , {ATP} , {bicarbonate} , {L-glutamine} , {ADP} , {carbamoyl phosphate} , {L-glutamate} , {phosphate}
 
 CDP-diacylglycerol synthase [CTP] + [phosphatidate] ↔ [CDP-diacylglycerol] + [diphosphate];   {CDS1} , {CTP} , {phosphatidate} , {CDP-diacylglycerol} , {diphosphate}
 
 ceramide-1 synthase (26C) [hexacosanoyl-CoA] + [sphinganine] ↔ [ceramide-1 (C26)] + [coenzyme A];   {LAC1} , {LAG1} , {LIP1} , {hexacosanoyl-CoA} , {sphinganine} , {ceramide-1 (C26)} , {coenzyme A}
 
 chorismate mutase [chorismate] ↔ [prephenate];   {ARO7} , {chorismate} , {prephenate}
 
 chorismate synthase [5-O-(1-carboxyvinyl)-3-phosphoshikimic acid] ↔ [chorismate] + [phosphate];   {ARO2} , {5-O-(1-carboxyvinyl)-3-phosphoshikimic acid} , {chorismate} , {phosphate}
 
 cis-aconitate(3-) to isocitrate [cis-aconitate] ↔ [isocitrate];   {ACO1} , {cis-aconitate} , {isocitrate}
 
 citrate synthase [acetyl-CoA] + [oxaloacetate] ↔ [citrate] + [coenzyme A];   {CIT3} , {CIT1} , {CIT2} , {acetyl-CoA} , {oxaloacetate} , {citrate} , {coenzyme A}
 
 citrate to cis-aconitate(3-) [citrate] ↔ [cis-aconitate];   {ACO1} , {citrate} , {cis-aconitate}
 
 CTP synthase (NH3) [ammonium] + [ATP] + [UTP] ↔ [ADP] + [CTP] + [phosphate];   {URA8} , {URA7} , {ammonium} , {ATP} , {UTP} , {ADP} , {CTP} , {phosphate}
 
 cystathionine beta-synthase [L-homocysteine] + [L-serine] ↔ [L-cystathionine];   {CYS4} , {L-homocysteine} , {L-serine} , {L-cystathionine}
 
 cystathionine g-lyase [L-cystathionine] ↔ [2-oxobutanoate] + [ammonium] + [L-cysteine];   {CYS3} , {L-cystathionine} , {2-oxobutanoate} , {ammonium} , {L-cysteine}
 
 cystathionine gamma-synthase [L-cysteine] + [O-acetyl-L-homoserine] ↔ [acetate] + [L-cystathionine];   {STR2} , {L-cysteine} , {O-acetyl-L-homoserine} , {acetate} , {L-cystathionine}
 
 cysteinyl-tRNA synthetase [ATP] + [L-cysteine] + [tRNA(Cys)] ↔ [AMP] + [Cys-tRNA(Cys)] + [diphosphate];   {YNL247W} , {ATP} , {L-cysteine} , {tRNA(Cys)} , {AMP} , {Cys-tRNA(Cys)} , {diphosphate}
 
 cytochrome P450 lanosterol 14-alpha-demethylase (NADP) [lanosterol] + 3.0 × [NADPH] + 3.0 × [oxygen] ↔ [4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol] + [formate] + 3.0 × [NADP(+)];   {NCP1} , {ERG11} , {lanosterol} , {NADPH} , {oxygen} , {4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol} , {formate} , {NADP(+)}
 
 dCMP deaminase [dCMP] ↔ [ammonium] + [dUMP];   {DCD1} , {dCMP} , {ammonium} , {dUMP}
 
 deoxyguanylate kinase (dGMP:ATP) [ADP] + [dGDP] ↔ [ATP] + [dGMP];   {GUK1} , {ADP} , {dGDP} , {ATP} , {dGMP}
 
 diacylglycerol acyltransferase [coenzyme A] + [triglyceride] ↔ [acyl-CoA] + [diglyceride];   {DGA1} , {coenzyme A} , {triglyceride} , {acyl-CoA} , {diglyceride}
 
 diacylglycerol pyrophosphate phosphatase [phosphatidate] ↔ [diglyceride] + [phosphate];   {DPP1} , {phosphatidate} , {diglyceride} , {phosphate}
 
 dihydrofolate reductase [dihydrofolic acid] + [NADPH] ↔ [NADP(+)] + [THF];   {DFR1} , {dihydrofolic acid} , {NADPH} , {NADP(+)} , {THF}
 
 dihydroorotase [N-carbamoyl-L-aspartate] ↔ [(S)-dihydroorotate];   {URA4} , {N-carbamoyl-L-aspartate} , {(S)-dihydroorotate}
 
 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) [(R)-2,3-dihydroxy-3-methylbutanoate] ↔ [3-methyl-2-oxobutanoate];   {ILV3} , {(R)-2,3-dihydroxy-3-methylbutanoate} , {3-methyl-2-oxobutanoate}
 
 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) [(2R,3R)-2,3-dihydroxy-3-methylpentanoate] ↔ [(S)-3-methyl-2-oxopentanoate];   {ILV3} , {(2R,3R)-2,3-dihydroxy-3-methylpentanoate} , {(S)-3-methyl-2-oxopentanoate}
 
 dimethylallyltranstransferase [isopentenyl diphosphate] + [prenyl diphosphate] ↔ [diphosphate] + [geranyl diphosphate];   {ERG20} , {isopentenyl diphosphate} , {prenyl diphosphate} , {diphosphate} , {geranyl diphosphate}
 
 dolichyl-phosphate D-mannosyltransferase [dolichyl phosphate] + [GDP-alpha-D-mannose] ↔ [dolichyl D-mannosyl phosphate] + [GDP];   {DPM1} , {dolichyl phosphate} , {GDP-alpha-D-mannose} , {dolichyl D-mannosyl phosphate} , {GDP}
 
 dolichyl-phosphate-mannose--protein mannosyltransferase [dolichyl D-mannosyl phosphate] ↔ [dolichyl phosphate] + [mannan];   {PMT5} , {PMT4} , {PMT2} , {PMT3} , {PMT1} , {dolichyl D-mannosyl phosphate} , {dolichyl phosphate} , {mannan}
 
 dUTP diphosphatase [dUTP] ↔ [diphosphate] + [dUMP];   {DUT1} , {dUTP} , {diphosphate} , {dUMP}
 
 enolase [2-phospho-D-glyceric acid] ↔ [phosphoenolpyruvate];   {ENO1} , {ENO2} , {2-phospho-D-glyceric acid} , {phosphoenolpyruvate}
 
 fatty acid synthase (n-C12:0) [decanoate] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [laurate] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {decanoate} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {laurate} , {NADP(+)}
 
 fatty acid synthase (n-C14:0) [laurate] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [myristate] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {laurate} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {myristate} , {NADP(+)}
 
 fatty acid synthase (n-C16:0) [malonyl-CoA] + [myristate] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [palmitate];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {myristate} , {NADPH} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {palmitate}
 
 fatty acid synthase (n-C18:0) [malonyl-CoA] + 2.0 × [NADPH] + [palmitate] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [stearate];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {NADPH} , {palmitate} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {stearate}
 
 fatty acid synthase (n-C24:0), lumped reaction 3.0 × [malonyl-CoA] + 6.0 × [NADPH] + [stearate] ↔ 3.0 × [carbon dioxide] + 3.0 × [coenzyme A] + [lignoceric acid] + 6.0 × [NADP(+)];   {TSC13} , {FEN1} , {SUR4} , {malonyl-CoA} , {NADPH} , {stearate} , {carbon dioxide} , {coenzyme A} , {lignoceric acid} , {NADP(+)}
 
 fatty acid synthase (n-C26:0) [lignoceric acid] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [cerotate] + [coenzyme A] + 2.0 × [NADP(+)];   {TSC13} , {FEN1} , {SUR4} , {lignoceric acid} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {cerotate} , {coenzyme A} , {NADP(+)}
 
 fatty acyl-CoA synthase (n-C10:0CoA) [malonyl-CoA] + 2.0 × [NADPH] + [octanoyl-CoA] ↔ [carbon dioxide] + [coenzyme A] + [decanoyl-CoA] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {NADPH} , {octanoyl-CoA} , {carbon dioxide} , {coenzyme A} , {decanoyl-CoA} , {NADP(+)}
 
 fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction [acetyl-CoA] + 3.0 × [malonyl-CoA] + 6.0 × [NADPH] ↔ 3.0 × [carbon dioxide] + 3.0 × [coenzyme A] + 6.0 × [NADP(+)] + [octanoyl-CoA];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {acetyl-CoA} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {octanoyl-CoA}
 
 fatty-acid--CoA ligase (decanoate) [AMP] + [decanoyl-CoA] + [diphosphate] ↔ [ATP] + [coenzyme A] + [decanoate];   {FAA2} , {AMP} , {decanoyl-CoA} , {diphosphate} , {ATP} , {coenzyme A} , {decanoate}
 
 fatty-acid--CoA ligase (dodecanoate) [ATP] + [coenzyme A] + [laurate] ↔ [AMP] + [diphosphate] + [lauroyl-CoA];   {FAA2} , {ATP} , {coenzyme A} , {laurate} , {AMP} , {diphosphate} , {lauroyl-CoA}
 
 fatty-acid--CoA ligase (n-C26:0) [ATP] + [cerotate] + [coenzyme A] ↔ [AMP] + [diphosphate] + [hexacosanoyl-CoA];   {FAT1} , {ATP} , {cerotate} , {coenzyme A} , {AMP} , {diphosphate} , {hexacosanoyl-CoA}
 
 fatty-acid--CoA ligase (octadecanoate) [AMP] + [diphosphate] + [stearoyl-CoA] ↔ [ATP] + [coenzyme A] + [stearate];   {FAA4} , {FAA1} , {FAA3} , {AMP} , {diphosphate} , {stearoyl-CoA} , {ATP} , {coenzyme A} , {stearate}
 
 fatty-acyl-CoA synthase (n-C12:0CoA) [decanoyl-CoA] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [lauroyl-CoA] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {decanoyl-CoA} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {lauroyl-CoA} , {NADP(+)}
 
 fatty-acyl-CoA synthase (n-C14:0CoA) [lauroyl-CoA] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [myristoyl-CoA] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {lauroyl-CoA} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {myristoyl-CoA} , {NADP(+)}
 
 fatty-acyl-CoA synthase (n-C16:0CoA) [malonyl-CoA] + [myristoyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [palmitoyl-CoA];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {myristoyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {palmitoyl-CoA}
 
 fatty-acyl-CoA synthase (n-C18:0CoA) [malonyl-CoA] + 2.0 × [NADPH] + [palmitoyl-CoA] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [stearoyl-CoA];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {NADPH} , {palmitoyl-CoA} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {stearoyl-CoA}
 
 ferrocytochrome-c:oxygen oxidoreductase 4.0 × [ferrocytochrome c] + [oxygen] ↔ 4.0 × [ferricytochrome c];   {COX12} , {COX3} , {COX5A} , {COX6} , {COX9} , {COX1} , {COX13} , {CYC7} , {COX7} , {COX8} , {COX2} , {CYC1} , {COX4} , {COX5B} , {ferrocytochrome c} , {oxygen} , {ferricytochrome c}
 
 ferrocytochrome-c:oxygen oxidoreductase 2.0 × [ferricytochrome c] + [ubiquinol-6] ↔ 2.0 × [ferrocytochrome c] + [ubiquinone-6];   {QCR8} , {QCR2} , {QCR10} , {RIP1} , {COB} , {QCR7} , {QCR9} , {CYC7} , {CYT1} , {COR1} , {CYC1} , {QCR6} , {ferricytochrome c} , {ubiquinol-6} , {ferrocytochrome c} , {ubiquinone-6}
 
 formate-tetrahydrofolate ligase [ATP] + [formate] + [THF] ↔ [10-formyl-THF] + [ADP] + [phosphate];   {ADE3} , {MIS1} , {ATP} , {formate} , {THF} , {10-formyl-THF} , {ADP} , {phosphate}
 
 fructose-bisphosphate aldolase [D-fructose 1,6-bisphosphate] ↔ [dihydroxyacetone phosphate] + [glyceraldehyde 3-phosphate];   {FBA1} , {D-fructose 1,6-bisphosphate} , {dihydroxyacetone phosphate} , {glyceraldehyde 3-phosphate}
 
 fumarase [fumarate] ↔ [(S)-malate];   {FUM1} , {fumarate} , {(S)-malate}
 
 geranyltranstransferase [geranyl diphosphate] + [isopentenyl diphosphate] ↔ [farnesyl diphosphate] + [diphosphate];   {ERG20} , {geranyl diphosphate} , {isopentenyl diphosphate} , {farnesyl diphosphate} , {diphosphate}
 
 glucose 6-phosphate dehydrogenase [D-glucose 6-phosphate] + [NADP(+)] ↔ [6-O-phosphono-D-glucono-1,5-lactone] + [NADPH];   {ZWF1} , {D-glucose 6-phosphate} , {NADP(+)} , {6-O-phosphono-D-glucono-1,5-lactone} , {NADPH}
 
 glucose-6-phosphate isomerase [D-glucose 6-phosphate] ↔ [D-fructose 6-phosphate];   {PGI1} , {D-glucose 6-phosphate} , {D-fructose 6-phosphate}
 
 glutamate dehydrogenase (NAD) [2-oxoglutarate] + [ammonium] + [NADH] ↔ [L-glutamate] + [NAD];   {GDH2} , {2-oxoglutarate} , {ammonium} , {NADH} , {L-glutamate} , {NAD}
 
 glutamine synthetase [ammonium] + [ATP] + [L-glutamate] ↔ [ADP] + [L-glutamine] + [phosphate];   {GLN1} , {ammonium} , {ATP} , {L-glutamate} , {ADP} , {L-glutamine} , {phosphate}
 
 glutaminyl-tRNA synthetase [ATP] + [L-glutamine] + [tRNA(Gln)] ↔ [AMP] + [diphosphate] + [Gln-tRNA(Gln)];   {GLN4} , {ATP} , {L-glutamine} , {tRNA(Gln)} , {AMP} , {diphosphate} , {Gln-tRNA(Gln)}
 
 glutamyl-tRNA synthetase [ATP] + [L-glutamate] + [tRNA(Glu)] ↔ [AMP] + [diphosphate] + [Glu-tRNA(Glu)];   {GUS1} , {ATP} , {L-glutamate} , {tRNA(Glu)} , {AMP} , {diphosphate} , {Glu-tRNA(Glu)}
 
 glyceraldehyde-3-phosphate dehydrogenase [glyceraldehyde 3-phosphate] + [NAD] + [phosphate] ↔ [1,3-bisphospho-D-glycerate] + [NADH];   {TDH3} , {TDH1} , {TDH2} , {glyceraldehyde 3-phosphate} , {NAD} , {phosphate} , {1,3-bisphospho-D-glycerate} , {NADH}
 
 glycerol-3-phosphatase [glycerol 3-phosphate] ↔ [glycerol] + [phosphate];   {RHR2} , {HOR2} , {glycerol 3-phosphate} , {glycerol} , {phosphate}
 
 glycerol-3-phosphate dehydrogenase (NAD) [dihydroxyacetone phosphate] + [NADH] ↔ [glycerol 3-phosphate] + [NAD];   {GPD1} , {GPD2} , {dihydroxyacetone phosphate} , {NADH} , {glycerol 3-phosphate} , {NAD}
 
 glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase [acyl-CoA] + [glycerol 3-phosphate] ↔ [1-acyl-sn-glycerol 3-phosphate] + [coenzyme A];   {SCT1} , {GPT2} , {acyl-CoA} , {glycerol 3-phosphate} , {1-acyl-sn-glycerol 3-phosphate} , {coenzyme A}
 
 glycinamide ribotide transformylase [10-formyl-THF] + [5-phospho-ribosyl-glycineamide] ↔ [5'-phosphoribosyl-N-formylglycineamide] + [THF];   {ADE8} , {10-formyl-THF} , {5-phospho-ribosyl-glycineamide} , {5'-phosphoribosyl-N-formylglycineamide} , {THF}
 
 glycine cleavage system [L-glycine] + [NAD] + [THF] ↔ [5,10-methylenetetrahydrofolate] + [ammonium] + [carbon dioxide] + [NADH];   {GCV2} , {GCV3} , {GCV1} , {LPD1} , {L-glycine} , {NAD} , {THF} , {5,10-methylenetetrahydrofolate} , {ammonium} , {carbon dioxide} , {NADH}
 
 glycine hydroxymethyltransferase [5,10-methylenetetrahydrofolate] + [L-glycine] ↔ [L-serine] + [THF];   {SHM2} , {SHM1} , {5,10-methylenetetrahydrofolate} , {L-glycine} , {L-serine} , {THF}
 
 glycogen (starch) synthase [UDP-D-glucose] ↔ [glycogen] + [UDP];   {GSY2} , {GLG2} , {GSY1} , {GLG1} , {UDP-D-glucose} , {glycogen} , {UDP}
 
 glycyl-tRNA synthetase [ATP] + [L-glycine] + [tRNA(Gly)] ↔ [AMP] + [diphosphate] + [Gly-tRNA(Gly)];   {GRS1} , {GRS2} , {ATP} , {L-glycine} , {tRNA(Gly)} , {AMP} , {diphosphate} , {Gly-tRNA(Gly)}
 
 GMP synthase [ATP] + [L-glutamine] + [xanthosine-5-phosphate] ↔ [AMP] + [diphosphate] + [GMP] + [L-glutamate];   {GUA1} , {ATP} , {L-glutamine} , {xanthosine-5-phosphate} , {AMP} , {diphosphate} , {GMP} , {L-glutamate}
 
 GTP cyclohydrolase II [GTP] ↔ [2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine] + [diphosphate] + [formate];   {RIB1} , {GTP} , {2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine} , {diphosphate} , {formate}
 
 guanylate kinase [ATP] + [GMP] ↔ [ADP] + [GDP];   {GUK1} , {ATP} , {GMP} , {ADP} , {GDP}
 
 guanylate kinase (GMP:dATP) [dATP] + [GMP] ↔ [dADP] + [GDP];   {GUK1} , {dATP} , {GMP} , {dADP} , {GDP}
 
 hexokinase (D-glucose:ATP) [ATP] + [D-glucose] ↔ [ADP] + [D-glucose 6-phosphate];   {GLK1} , {HXK1} , {HXK2} , {D-glucose} , {ATP} , {D-glucose 6-phosphate} , {ADP}
 
 histidinol dehydrogenase [L-histidinol] + 2.0 × [NAD] ↔ [L-histidine] + 2.0 × [NADH];   {HIS4} , {L-histidinol} , {NAD} , {L-histidine} , {NADH}
 
 histidinol-phosphatase [L-histidinol phosphate] ↔ [L-histidinol] + [phosphate];   {HIS2} , {L-histidinol phosphate} , {L-histidinol} , {phosphate}
 
 histidinol-phosphate transaminase [3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-histidinol phosphate];   {HIS5} , {3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate} , {L-glutamate} , {2-oxoglutarate} , {L-histidinol phosphate}
 
 histidyl-tRNA synthetase [ATP] + [L-histidine] + [tRNA(His)] ↔ [AMP] + [diphosphate] + [His-tRNA(His)];   {HTS1} , {ATP} , {L-histidine} , {tRNA(His)} , {AMP} , {diphosphate} , {His-tRNA(His)}
 
 homoacontinate hydratase [but-1-ene-1,2,4-tricarboxylic acid] ↔ [homoisocitrate];   {LYS4} , {but-1-ene-1,2,4-tricarboxylic acid} , {homoisocitrate}
 
 homocitrate synthase [2-oxoglutarate] + [acetyl-CoA] ↔ [coenzyme A] + [homocitrate];   {LYS20} , {LYS21} , {2-oxoglutarate} , {acetyl-CoA} , {coenzyme A} , {homocitrate}
 
 homoisocitrate dehydrogenase [homoisocitrate] + [NAD] ↔ [2-oxoadipic acid] + [NADH] + [carbon dioxide];   {LYS12} , {homoisocitrate} , {NAD} , {2-oxoadipic acid} , {NADH} , {carbon dioxide}
 
 homoserine dehydrogenase (NADP) [L-aspartate 4-semialdehyde] + [NADPH] ↔ [L-homoserine] + [NADP(+)];   {HOM6} , {L-aspartate 4-semialdehyde} , {NADPH} , {L-homoserine} , {NADP(+)}
 
 homoserine kinase [ATP] + [L-homoserine] ↔ [ADP] + [O-phospho-L-homoserine];   {THR1} , {ATP} , {L-homoserine} , {ADP} , {O-phospho-L-homoserine}
 
 homoserine O-trans-acetylase [acetyl-CoA] + [L-homoserine] ↔ [coenzyme A] + [O-acetyl-L-homoserine];   {MET2} , {acetyl-CoA} , {L-homoserine} , {coenzyme A} , {O-acetyl-L-homoserine}
 
 hydroxyacylglutathione hydrolase [(R)-S-lactoylglutathione] ↔ [(R)-lactate] + [glutathione];   {GLO2} , {GLO4} , {(R)-S-lactoylglutathione} , {(R)-lactate} , {glutathione}
 
 hydroxymethylglutaryl CoA reductase [3-hydroxy-3-methylglutaryl-CoA] + 2.0 × [NADPH] ↔ [(R)-mevalonate] + [coenzyme A] + 2.0 × [NADP(+)];   {HMG2} , {HMG1} , {3-hydroxy-3-methylglutaryl-CoA} , {NADPH} , {(R)-mevalonate} , {coenzyme A} , {NADP(+)}
 
 hydroxymethylglutaryl CoA synthase [acetoacetyl-CoA] + [acetyl-CoA] ↔ [3-hydroxy-3-methylglutaryl-CoA] + [coenzyme A];   {ERG13} , {acetoacetyl-CoA} , {acetyl-CoA} , {3-hydroxy-3-methylglutaryl-CoA} , {coenzyme A}
 
 Imidazole-glycerol-3-phosphate synthase [5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide] + [L-glutamine] ↔ [AICAR] + [D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate] + [L-glutamate];   {HIS7} , {5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide} , {L-glutamine} , {AICAR} , {D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate} , {L-glutamate}
 
 imidazoleglycerol-phosphate dehydratase [D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate] ↔ [3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate];   {HIS3} , {D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate} , {3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate}
 
 IMP dehydrogenase [IMP] + [NAD] ↔ [NADH] + [xanthosine-5-phosphate];   {IMD4} , {IMD2} , {IMD3} , {IMP} , {NAD} , {NADH} , {xanthosine-5-phosphate}
 
 indole-3-glycerol-phosphate synthase [1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate] ↔ [1-C-(indol-3-yl)glycerol 3-phosphate] + [carbon dioxide];   {TRP3} , {1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate} , {1-C-(indol-3-yl)glycerol 3-phosphate} , {carbon dioxide}
 
 inorganic diphosphatase [diphosphate] ↔ 2.0 × [phosphate];   {IPP1} , {PPA2} , {diphosphate} , {phosphate}
 
 inosine monophosphate cyclohydrolase [phosphoribosyl-formamido-carboxamide] ↔ [IMP];   {ADE16} , {ADE17} , {phosphoribosyl-formamido-carboxamide} , {IMP}
 
 IPC synthase [1-phosphatidyl-1D-myo-inositol] + [ceramide-1 (C26)] ↔ [diglyceride] + [inositol-P-ceramide A (C26)];   {AUR1} , {KEI1} , {1-phosphatidyl-1D-myo-inositol} , {ceramide-1 (C26)} , {diglyceride} , {inositol-P-ceramide A (C26)}
 
 isocitrate dehydrogenase (NAD+) [isocitrate] + [NAD] ↔ [2-oxoglutarate] + [carbon dioxide] + [NADH];   {IDH2} , {IDH1} , {isocitrate} , {NAD} , {2-oxoglutarate} , {carbon dioxide} , {NADH}
 
 isocitrate dehydrogenase (NADP+), peroxisomal [isocitrate] + [NADP(+)] ↔ [2-oxoglutarate] + [carbon dioxide] + [NADPH];   {IDP3} , {IDP1} , {isocitrate} , {NADP(+)} , {2-oxoglutarate} , {carbon dioxide} , {NADPH}
 
 isocitrate lyase [isocitrate] ↔ [glyoxylate] + [succinate];   {ICL1} , {isocitrate} , {glyoxylate} , {succinate}
 
 isoleucine transaminase [(S)-3-methyl-2-oxopentanoate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-isoleucine];   {BAT2} , {BAT1} , {(S)-3-methyl-2-oxopentanoate} , {L-glutamate} , {2-oxoglutarate} , {L-isoleucine}
 
 isoleucyl-tRNA synthetase [ATP] + [L-isoleucine] + [tRNA(Ile)] ↔ [AMP] + [diphosphate] + [Ile-tRNA(Ile)];   {ILS1} , {ATP} , {L-isoleucine} , {tRNA(Ile)} , {AMP} , {diphosphate} , {Ile-tRNA(Ile)}
 
 isopentenyl-diphosphate D-isomerase [isopentenyl diphosphate] ↔ [prenyl diphosphate];   {IDI1} , {isopentenyl diphosphate} , {prenyl diphosphate}
 
 ketol-acid reductoisomerase (2-aceto-2-hydroxybutanoate) [(S)-2-acetyl-2-hydroxybutanoate] + [NADPH] ↔ [(2R,3R)-2,3-dihydroxy-3-methylpentanoate] + [NADP(+)];   {ILV5} , {(S)-2-acetyl-2-hydroxybutanoate} , {NADPH} , {(2R,3R)-2,3-dihydroxy-3-methylpentanoate} , {NADP(+)}
 
 L-alanine transaminase [L-glutamate] + [pyruvate] ↔ [2-oxoglutarate] + [L-alanine];   {ALT1} , {L-glutamate} , {pyruvate} , {2-oxoglutarate} , {L-alanine}
 
 L-aminoadipate-semialdehyde dehydrogenase (NADPH) [L-2-aminoadipate] + [NADPH] ↔ [L-allysine] + [NADP(+)];   {LYS2} , {LYS5} , {L-2-aminoadipate} , {NADPH} , {L-allysine} , {NADP(+)}
 
 L-lactaldehyde:NADP+ 1-oxidoreductase [methylglyoxal] + [NADPH] ↔ [(S)-lactaldehyde] + [NADP(+)];   {GRE2} , {GRE3} , {methylglyoxal} , {NADPH} , {(S)-lactaldehyde} , {NADP(+)}
 
 L-threonine deaminase [L-threonine] ↔ [2-oxobutanoate] + [ammonium];   {CHA1} , {ILV1} , {L-threonine} , {2-oxobutanoate} , {ammonium}
 
 lactaldehyde dehydrogenase [(S)-lactaldehyde] + [NAD] ↔ [(S)-lactate] + [NADH];   {(S)-lactaldehyde} , {NAD} , {(S)-lactate} , {NADH}
 
 lactoylglutathione lyase [glutathione] + [methylglyoxal] ↔ [(R)-S-lactoylglutathione];   {GLO1} , {glutathione} , {methylglyoxal} , {(R)-S-lactoylglutathione}
 
 lanosterol synthase [(S)-2,3-epoxysqualene] ↔ [lanosterol];   {ERG7} , {(S)-2,3-epoxysqualene} , {lanosterol}
 
 leucine transaminase [4-methyl-2-oxopentanoate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-leucine];   {BAT2} , {BAT1} , {4-methyl-2-oxopentanoate} , {L-glutamate} , {2-oxoglutarate} , {L-leucine}
 
 leucyl-tRNA synthetase [ATP] + [L-leucine] + [tRNA(Leu)] ↔ [AMP] + [diphosphate] + [Leu-tRNA(Leu)];   {CDC60} , {ATP} , {L-leucine} , {tRNA(Leu)} , {AMP} , {diphosphate} , {Leu-tRNA(Leu)}
 
 lysyl-tRNA synthetase [ATP] + [L-lysine] + [tRNA(Lys)] ↔ [AMP] + [diphosphate] + [Lys-tRNA(Lys)];   {KRS1} , {ATP} , {L-lysine} , {tRNA(Lys)} , {AMP} , {diphosphate} , {Lys-tRNA(Lys)}
 
 malate dehydrogenase [(S)-malate] + [NAD] ↔ [NADH] + [oxaloacetate];   {MDH1} , {MDH2} , {MDH3} , {(S)-malate} , {NAD} , {NADH} , {oxaloacetate}
 
 mannose-1-phosphate guanylyltransferase [D-mannose 1-phosphate] + [GTP] ↔ [diphosphate] + [GDP-alpha-D-mannose];   {PSA1} , {D-mannose 1-phosphate} , {GTP} , {diphosphate} , {GDP-alpha-D-mannose}
 
 mannose-6-phosphate isomerase [D-fructose 6-phosphate] ↔ [D-mannose 6-phosphate];   {PMI40} , {D-fructose 6-phosphate} , {D-mannose 6-phosphate}
 
 methenyltetrahydrifikate cyclohydrolase [5,10-methenyl-THF] ↔ [10-formyl-THF];   {MIS1} , {ADE3} , {5,10-methenyl-THF} , {10-formyl-THF}
 
 methionine adenosyltransferase [ATP] + [L-methionine] ↔ [diphosphate] + [phosphate] + [S-adenosyl-L-methionine];   {SAM2} , {SAM1} , {ATP} , {L-methionine} , {diphosphate} , {phosphate} , {S-adenosyl-L-methionine}
 
 methionine synthase [5-methyltetrahydrofolate] + [L-homocysteine] ↔ [L-methionine] + [THF];   {MET6} , {5-methyltetrahydrofolate} , {L-homocysteine} , {L-methionine} , {THF}
 
 methionyl-tRNA synthetase [ATP] + [L-methionine] + [tRNA(Met)] ↔ [AMP] + [diphosphate] + [Met-tRNA(Met)];   {MES1} , {ATP} , {L-methionine} , {tRNA(Met)} , {AMP} , {diphosphate} , {Met-tRNA(Met)}
 
 methylenetetrahydrofolate dehydrogenase (NAD) [5,10-methenyl-THF] + [NADH] ↔ [5,10-methylenetetrahydrofolate] + [NAD];   {MTD1} , {5,10-methenyl-THF} , {NADH} , {5,10-methylenetetrahydrofolate} , {NAD}
 
 methylenetetrahydrofolate dehydrogenase (NADP) [5,10-methylenetetrahydrofolate] + [NADP(+)] ↔ [5,10-methenyl-THF] + [NADPH];   {ADE3} , {MIS1} , {5,10-methylenetetrahydrofolate} , {NADP(+)} , {5,10-methenyl-THF} , {NADPH}
 
 mevalonate kinase (atp) [(R)-mevalonate] + [ATP] ↔ [(R)-5-phosphomevalonic acid] + [ADP];   {ERG12} , {(R)-mevalonate} , {ATP} , {(R)-5-phosphomevalonic acid} , {ADP}
 
 mevalonate kinase (ctp) [(R)-mevalonate] + [CTP] ↔ [(R)-5-phosphomevalonic acid] + [CDP];   {ERG12} , {(R)-mevalonate} , {CTP} , {(R)-5-phosphomevalonic acid} , {CDP}
 
 mevalonate pyrophoshate decarboxylase [(R)-5-diphosphomevalonic acid] + [ATP] ↔ [ADP] + [carbon dioxide] + [isopentenyl diphosphate] + [phosphate];   {MVD1} , {(R)-5-diphosphomevalonic acid} , {ATP} , {ADP} , {carbon dioxide} , {isopentenyl diphosphate} , {phosphate}
 
 myo-inositol 1-phosphatase [1D-myo-inositol 1-phosphate] ↔ [myo-inositol] + [phosphate];   {INM2} , {INM1} , {1D-myo-inositol 1-phosphate} , {myo-inositol} , {phosphate}
 
 myo-inositol-1-phosphate synthase [D-glucose 6-phosphate] ↔ [1D-myo-inositol 1-phosphate];   {INO1} , {D-glucose 6-phosphate} , {1D-myo-inositol 1-phosphate}
 
 N-acetyl-g-glutamyl-phosphate reductase [N-acetyl-L-gamma-glutamyl phosphate] + [NADPH] ↔ [2-acetamido-5-oxopentanoate] + [NADP(+)] + [phosphate];   {ARG5,6} , {N-acetyl-L-gamma-glutamyl phosphate} , {NADPH} , {2-acetamido-5-oxopentanoate} , {NADP(+)} , {phosphate}
 
 nucleoside diphosphatase [CDP] ↔ [CMP] + [phosphate];   {YND1} , {CDP} , {CMP} , {phosphate}
 
 nucleoside diphosphate kinase [ATP] + [GDP] ↔ [ADP] + [GTP];   {YNK1} , {ATP} , {GDP} , {ADP} , {GTP}
 
 nucleoside-diphosphate kinase (ATP:UDP) [ATP] + [UDP] ↔ [ADP] + [UTP];   {YNK1} , {ATP} , {UDP} , {ADP} , {UTP}
 
 O-acetylhomoserine (thiol)-lyase [hydrogen sulfide] + [O-acetyl-L-homoserine] ↔ [acetate] + [L-homocysteine];   {MET17} , {hydrogen sulfide} , {O-acetyl-L-homoserine} , {acetate} , {L-homocysteine}
 
 ornithine carbamoyltransferase [carbamoyl phosphate] + [ornithine] ↔ [L-citrulline] + [phosphate];   {ARG3} , {carbamoyl phosphate} , {ornithine} , {L-citrulline} , {phosphate}
 
 ornithine transacetylase [L-glutamate] + [N(2)-acetyl-L-ornithine] ↔ [N-acetyl-L-glutamate] + [ornithine];   {ARG7} , {L-glutamate} , {N(2)-acetyl-L-ornithine} , {N-acetyl-L-glutamate} , {ornithine}
 
 orotate phosphoribosyltransferase [orotate] + [PRPP] ↔ [diphosphate] + [orotidine 5'-(dihydrogen phosphate)];   {URA10} , {URA5} , {orotate} , {PRPP} , {diphosphate} , {orotidine 5'-(dihydrogen phosphate)}
 
 orotidine-5'-phosphate decarboxylase [orotidine 5'-(dihydrogen phosphate)] ↔ [carbon dioxide] + [UMP];   {URA3} , {orotidine 5'-(dihydrogen phosphate)} , {carbon dioxide} , {UMP}
 
 phenylalanine transaminase [keto-phenylpyruvate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-phenylalanine];   {ARO8} , {keto-phenylpyruvate} , {L-glutamate} , {2-oxoglutarate} , {L-phenylalanine}
 
 phenylalanyl-tRNA synthetase [ATP] + [L-phenylalanine] + [tRNA(Phe)] ↔ [AMP] + [diphosphate] + [Phe-tRNA(Phe)];   {FRS1} , {FRS2} , {ATP} , {L-phenylalanine} , {tRNA(Phe)} , {AMP} , {diphosphate} , {Phe-tRNA(Phe)}
 
 phopshoribosylaminoimidazole synthetase [5'-phosphoribosyl-N-formylglycineamidine] + [ATP] ↔ [5'-phosphoribosyl-5-aminoimidazole] + [ADP] + [phosphate];   {ADE5,7} , {5'-phosphoribosyl-N-formylglycineamidine} , {ATP} , {5'-phosphoribosyl-5-aminoimidazole} , {ADP} , {phosphate}
 
 phosphatidylethanolamine methyltransferase [phosphatidylethanolamine] + [S-adenosyl-L-methionine] ↔ [phosphatidyl-N-methylethanolamine] + [S-adenosyl-L-homocysteine];   {OPI3} , {CHO2} , {phosphatidylethanolamine} , {S-adenosyl-L-methionine} , {phosphatidyl-N-methylethanolamine} , {S-adenosyl-L-homocysteine}
 
 phosphatidylinositol synthase [CDP-diacylglycerol] + [myo-inositol] ↔ [1-phosphatidyl-1D-myo-inositol] + [CMP];   {PIS1} , {CDP-diacylglycerol} , {myo-inositol} , {1-phosphatidyl-1D-myo-inositol} , {CMP}
 
 phosphatidylserine decarboxylase [phosphatidyl-L-serine] ↔ [carbon dioxide] + [phosphatidylethanolamine];   {PSD1} , {PSD2} , {phosphatidyl-L-serine} , {carbon dioxide} , {phosphatidylethanolamine}
 
 phosphatidylserine synthase [CDP-diacylglycerol] + [L-serine] ↔ [CMP] + [phosphatidyl-L-serine];   {CHO1} , {CDP-diacylglycerol} , {L-serine} , {CMP} , {phosphatidyl-L-serine}
 
 phosphoadenylyl-sulfate reductase (thioredoxin) [3'-phospho-5'-adenylyl sulfate] + [TRX1] ↔ [adenosine 3',5'-bismonophosphate] + [sulphite] + [TRX1 disulphide];   {TRX1} , {MET16} , {TRX2} , {3'-phospho-5'-adenylyl sulfate} , {TRX1} , {adenosine 3',5'-bismonophosphate} , {sulphite} , {TRX1 disulphide}
 
 phosphoenolpyruvate carboxykinase [ATP] + [oxaloacetate] ↔ [ADP] + [carbon dioxide] + [phosphoenolpyruvate];   {PCK1} , {ATP} , {oxaloacetate} , {ADP} , {carbon dioxide} , {phosphoenolpyruvate}
 
 phosphofructokinase [ATP] + [D-fructose 6-phosphate] ↔ [ADP] + [D-fructose 1,6-bisphosphate];   {PFK1} , {PFK2} , {AMP} , {beta-D-fructose 2,6-bisphosphate} , {D-fructose 6-phosphate} , {ATP} , {AMP} , {beta-D-fructose 2,6-bisphosphate} , {D-fructose 1,6-bisphosphate}
 
 phosphoglucomutase [D-glucose 6-phosphate] ↔ [D-glucose 1-phosphate];   {PGM1} , {PGM3} , {PGM2} , {D-glucose 6-phosphate} , {D-glucose 1-phosphate}
 
 phosphogluconate dehydrogenase [6-phospho-D-gluconate] + [NADP(+)] ↔ [carbon dioxide] + [D-ribulose 5-phosphate] + [NADPH];   {GND1} , {GND2} , {6-phospho-D-gluconate} , {NADP(+)} , {carbon dioxide} , {D-ribulose 5-phosphate} , {NADPH}
 
 phosphoglycerate kinase [1,3-bisphospho-D-glycerate] + [ADP] ↔ [3-phosphoglycerate] + [ATP];   {PGK1} , {1,3-bisphospho-D-glycerate} , {ADP} , {3-phosphoglycerate} , {ATP}
 
 phosphoglycerate mutase [3-phosphoglycerate] ↔ [2-phospho-D-glyceric acid];   {GPM1} , {3-phosphoglycerate} , {2-phospho-D-glyceric acid}
 
 phospholipid methyltransferase [phosphatidyl-N,N-dimethylethanolamine] + [S-adenosyl-L-methionine] ↔ [phosphatidylcholine] + [S-adenosyl-L-homocysteine];   {OPI3} , {phosphatidyl-N,N-dimethylethanolamine} , {S-adenosyl-L-methionine} , {phosphatidylcholine} , {S-adenosyl-L-homocysteine}
 
 phospholipid methyltransferase [phosphatidyl-N-methylethanolamine] + [S-adenosyl-L-methionine] ↔ [phosphatidyl-N,N-dimethylethanolamine] + [S-adenosyl-L-homocysteine];   {OPI3} , {phosphatidyl-N-methylethanolamine} , {S-adenosyl-L-methionine} , {phosphatidyl-N,N-dimethylethanolamine} , {S-adenosyl-L-homocysteine}
 
 phosphomannomutase [D-mannose 6-phosphate] ↔ [D-mannose 1-phosphate];   {SEC53} , {D-mannose 6-phosphate} , {D-mannose 1-phosphate}
 
 phosphomevalonate kinase