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BIOMD0000000472 - Smallbone2013 - Yeast metabolic model with modular rate law

 

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Reference Publication
Publication ID: 10.1089/ind.2013.000...
Messiha HL, Kent E, Malys N, Carroll KM, Mendes P, Smallbone K.
Large-Scale Metabolic Models: From Reconstruction to Differential Equations
Industrial Biotechnology
Manchester Centre for Integrative Systems Biology and School of Computer Science, University of Manchester, Manchester Institute of Biotechnology, Manchester, UK  [more]
Model
Original Model: BIOMD0000000472.origin
Submitter: Kieran Smallbone
Submission ID: MODEL1302140004
Submission Date: 14 Feb 2013 10:59:51 UTC
Last Modification Date: 29 Apr 2014 11:44:51 UTC
Creation Date: 20 Feb 2008 10:05:10 UTC
Encoders:  Nick Juty
   Vijayalakshmi Chelliah
   Kieran Smallbone
set #1
bqbiol:isVersionOf Gene Ontology metabolic process
set #2
bqbiol:hasTaxon Taxonomy Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Notes
Model
Publication ID: 10.1089/ind.2013.000... Submission Date: 14 Feb 2013 10:59:51 UTC Last Modification Date: 29 Apr 2014 11:44:51 UTC Creation Date: 20 Feb 2008 10:05:10 UTC
Mathematical expressions
Reactions
1,3-beta-glucan synthase 1,6-beta-glucan synthase 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase 1-acyl-sn-gylcerol-3-phosphate acyltransferase
1-pyrroline-5-carboxylate dehydrogenase 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (NADPH) 2-aceto-2-hydroxybutanoate synthase
2-aminoadipate transaminase 2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase 2-isopropylmalate hydratase 2-isopropylmalate synthase
2-methylcitrate dehydratase 2-oxo-4-methyl-3-carboxypentanoate decarboxylation 3',5'-bisphosphate nucleotidase 3,4-dihydroxy-2-butanone-4-phosphate synthase
3-dehydroquinate dehydratase 3-dehydroquinate synthase 3-dehydrosphinganine reductase 3-isopropylmalate dehydratase
3-isopropylmalate dehydrogenase 3-phosphoshikimate 1-carboxyvinyltransferase 5'-phosphoribosylformyl glycinamidine synthetase 5,10-methylenetetrahydrofolate reductase (NADPH)
acetohydroxy acid isomeroreductase acetolactate synthase acetyl-CoA C-acetyltransferase acetyl-Coa carboxylase
acetyl-CoA hydrolase acetylglutamate kinase acteylornithine transaminase adenosine kinase
adenosylhomocysteinase adenylate kinase adenylosuccinate lyase (AICAR) adenylosuccinate lyase
adenylosuccinate synthase adenylyl-sulfate kinase alanyl-tRNA synthetase alpha,alpha-trehalose-phosphate synthase (UDP-forming)
anthranilate phosphoribosyltransferase anthranilate synthase argininosuccinate lyase argininosuccinate synthase
arginyl-tRNA synthetase asparagine synthase (glutamine-hydrolysing) Asparaginyl-tRNA synthetase aspartate carbamoyltransferase
aspartate kinase aspartate transaminase aspartate-semialdehyde dehydrogenase Aspartyl-tRNA synthetase
ATP phosphoribosyltransferase C-14 sterol reductase C-22 sterol desaturase (NADP) C-3 sterol dehydrogenase
C-3 sterol dehydrogenase (4-methylzymosterol) C-3 sterol keto reductase (4-methylzymosterol) C-3 sterol keto reductase (zymosterol) C-4 methyl sterol oxidase
C-4 methyl sterol oxidase C-4 methyl sterol oxidase C-4 sterol methyl oxidase (4,4-dimethylzymosterol) C-5 sterol desaturase
C-8 sterol isomerase C-s24 sterol reductase carbamoyl-phosphate synthase (glutamine-hydrolysing) CDP-diacylglycerol synthase
ceramide-1 hydroxylase (24C) ceramide-3 synthase (24C) ceramide-4 synthase (24C) chorismate mutase
chorismate synthase cis-aconitate(3-) to isocitrate citrate synthase citrate to cis-aconitate(3-)
CTP synthase (NH3) cystathionine beta-synthase cystathionine g-lyase cystathionine gamma-synthase
cysteinyl-tRNA synthetase cytochrome P450 lanosterol 14-alpha-demethylase (NADP) dCMP deaminase deoxyguanylate kinase (dGMP:ATP)
diacylglycerol acyltransferase diacylglycerol pyrophosphate phosphatase dihydoorotic acid dehydrogenase dihydroceramidase
dihydrofolate reductase dihydroorotase dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)
dimethylallyltranstransferase dolichyl-phosphate D-mannosyltransferase dolichyl-phosphate-mannose--protein mannosyltransferase dUTP diphosphatase
enolase fatty acid synthase (n-C12:0) fatty acid synthase (n-C14:0) fatty acid synthase (n-C16:0)
fatty acid synthase (n-C18:0) fatty acid synthase (n-C24:0), lumped reaction fatty acyl-CoA synthase (n-C10:0CoA) fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
fatty-acid--CoA ligase (decanoate) fatty-acid--CoA ligase (dodecanoate) fatty-acid--CoA ligase (octadecanoate) fatty-acyl-CoA synthase (n-C12:0CoA)
fatty-acyl-CoA synthase (n-C14:0CoA) fatty-acyl-CoA synthase (n-C16:0CoA) fatty-acyl-CoA synthase (n-C18:0CoA) ferrocytochrome-c:oxygen oxidoreductase
ferrocytochrome-c:oxygen oxidoreductase formate-tetrahydrofolate ligase fructose-bisphosphate aldolase fumarase
geranyltranstransferase glucose-6-phosphate isomerase glutamate dehydrogenase (NAD) glutamate dehydrogenase (NADP)
glutamine synthetase glutaminyl-tRNA synthetase glutamyl-tRNA synthetase glutathione oxidoreductase
glutathione peridoxase glyceraldehyde-3-phosphate dehydrogenase glycerol-3-phosphate dehydrogenase (NAD) glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase
glycinamide ribotide transformylase glycine cleavage system glycine hydroxymethyltransferase glycogen (starch) synthase
glycyl-tRNA synthetase GMP synthase GTP cyclohydrolase II guanylate kinase
guanylate kinase (GMP:dATP) hexokinase (D-glucose:ATP) histidinol dehydrogenase histidinol-phosphatase
histidinol-phosphate transaminase histidyl-tRNA synthetase homoacontinate hydratase homocitrate synthase
homoisocitrate dehydrogenase homoserine dehydrogenase (NADP) homoserine kinase homoserine O-trans-acetylase
hydrogen peroxide reductase (thioredoxin) hydroxymethylglutaryl CoA reductase hydroxymethylglutaryl CoA synthase Imidazole-glycerol-3-phosphate synthase
imidazoleglycerol-phosphate dehydratase IMP dehydrogenase indole-3-glycerol-phosphate synthase inorganic diphosphatase
inosine monophosphate cyclohydrolase IPC synthase isocitrate dehydrogenase (NAD+) isocitrate dehydrogenase (NADP+), peroxisomal
isoleucine transaminase isoleucyl-tRNA synthetase isopentenyl-diphosphate D-isomerase ketol-acid reductoisomerase (2-aceto-2-hydroxybutanoate)
L-alanine transaminase L-aminoadipate-semialdehyde dehydrogenase (NADPH) lanosterol synthase leucine transaminase
leucyl-tRNA synthetase lysyl-tRNA synthetase malate dehydrogenase mannose-1-phosphate guanylyltransferase
mannose-6-phosphate isomerase methenyltetrahydrifikate cyclohydrolase methionine adenosyltransferase methionine synthase
methionyl-tRNA synthetase methylenetetrahydrofolate dehydrogenase (NAD) methylenetetrahydrofolate dehydrogenase (NADP) mevalonate kinase (ctp)
mevalonate pyrophoshate decarboxylase myo-inositol 1-phosphatase myo-inositol-1-phosphate synthase N-acetyl-g-glutamyl-phosphate reductase
NADH dehydrogenase, cytosolic/mitochondrial nucleoside diphosphatase nucleoside diphosphate kinase nucleoside-diphosphate kinase (ATP:UDP)
O-acetylhomoserine (thiol)-lyase ornithine carbamoyltransferase ornithine transacetylase orotate phosphoribosyltransferase
orotidine-5'-phosphate decarboxylase phenylalanine transaminase phenylalanyl-tRNA synthetase phopshoribosylaminoimidazole synthetase
phosphatidylethanolamine methyltransferase phosphatidylinositol synthase phosphatidylserine decarboxylase phosphatidylserine synthase
phosphoadenylyl-sulfate reductase (thioredoxin) phosphofructokinase phosphoglucomutase phosphoglycerate dehydrogenase
phosphoglycerate kinase phosphoglycerate mutase phospholipid methyltransferase phospholipid methyltransferase
phosphomannomutase phosphomevalonate kinase phosphoribosyl amino imidazolesuccinocarbozamide synthetase phosphoribosyl-AMP cyclohydrolase
phosphoribosyl-ATP pyrophosphatase phosphoribosylaminoimidazole-carboxylase phosphoribosylaminoimidazolecarboxamide formyltransferase phosphoribosylanthranilate isomerase
phosphoribosylglycinamidine synthetase phosphoribosylpyrophosphate amidotransferase phosphoribosylpyrophosphate synthetase phosphoserine phosphatase (L-serine)
phosphoserine transaminase phytoceramidase phytosphingosine synthesis prephenate dehydratase
prephenate dehydrogenase (NADP) prolyl-tRNA synthetase pyrroline-5-carboxylate reductase pyruvate carboxylase
pyruvate dehydrogenase pyruvate kinase riboflavin synthase riboflavin synthase
ribonucleoside-triphosphate reductase (ATP) ribonucleoside-triphosphate reductase (UTP) ribonucleotide reductase ribonucleotide reductase
ribonucleotide reductase ribose-5-phosphate isomerase ribulose 5-phosphate 3-epimerase S-adenosyl-methionine delta-24-sterol-c-methyltransferase
saccharopine dehydrogenase (NAD, L-lysine forming) saccharopine dehydrogenase (NADP, L-glutamate forming) serine palmitotransferase seryl-tRNA synthetase
shikimate dehydrogenase shikimate kinase squalene epoxidase (NAD) squalene epoxidase (NADP)
squalene synthase steryl ester hydrolase sulfate adenylyltransferase (ADP) sulfite reductase (NADPH2)
thioredoxin reductase (NADPH) threonine synthase threonyl-tRNA synthetase thymidylate synthase
transaldolase transketolase 1 transketolase 2 trehalose-phosphatase
triacylglycerol lipase triose-phosphate isomerase tryptophan synthase (indoleglycerol phosphate) tryptophanyl-tRNA synthetase
tyrosine transaminase tyrosyl-tRNA synthetase UMP kinase UTP-glucose-1-phosphate uridylyltransferase
valine transaminase valyl-tRNA synthetase ammonia transport glucose transport
phosphate transport sulfate uniport bicarbonate formation CO2 transport
cytidylate kinase (dCMP) deoxyadenylate kinase formate transport O2 transport
pyrimidine phosphatase growth    
Physical entities
Compartments Species
cell (1->3)-beta-D-glucan (1->6)-beta-D-glucan (2R,3R)-2,3-dihydroxy-3-methylpentanoate
(2R,3S)-3-isopropylmalate (2S)-2-isopropyl-3-oxosuccinate (N(omega)-L-arginino)succinic acid
(R)-2,3-dihydroxy-3-methylbutanoate (R)-5-diphosphomevalonic acid (R)-5-phosphomevalonic acid
(R)-mevalonate (S)-2,3-epoxysqualene (S)-2-acetyl-2-hydroxybutanoate
(S)-3-methyl-2-oxopentanoate (S)-dihydroorotate (S)-malate
1,3-bisphospho-D-glycerate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
1-(5-phosphoribosyl)-5'-AMP 1-acyl-sn-glycerol 3-phosphate 1-C-(indol-3-yl)glycerol 3-phosphate
1-phosphatidyl-1D-myo-inositol 1-pyrroline-5-carboxylate 10-formyl-THF
14-demethyllanosterol 1D-myo-inositol 1-phosphate 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine
2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone 2-acetamido-5-oxopentanoate 2-acetyllactic acid
2-hydroxy-3-oxobutyl phosphate 2-isopropylmalate 2-isopropylmaleic acid
2-oxoadipic acid 2-oxobutanoate 2-oxoglutarate
2-phospho-D-glyceric acid farnesyl diphosphate 3'-phospho-5'-adenylyl sulfate
3-(4-hydroxyphenyl)pyruvate 3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate 3-dehydro-4-methylzymosterol
3-dehydroquinate 3-dehydroshikimate 3-hydroxy-3-methylglutaryl-CoA
3-ketosphinganine 3-methyl-2-oxobutanoate 3-phospho-hydroxypyruvate
3-phospho-serine 3-phosphoglycerate 3-phosphoshikimic acid
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol 4-methyl-2-oxopentanoate 4-phospho-L-aspartate
4alpha-methylzymosterol 4beta-methylzymosterol-4alpha-carboxylic acid 5'-adenylyl sulfate
5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole 5'-phosphoribosyl-5-aminoimidazole 5'-phosphoribosyl-N-formylglycineamide
5'-phosphoribosyl-N-formylglycineamidine 5,10-methenyl-THF 5,10-methylenetetrahydrofolate
5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 5-amino-6-(5-phosphoribitylamino)uracil 5-amino-6-(D-ribitylamino)uracil
5-methyltetrahydrofolate 5-O-(1-carboxyvinyl)-3-phosphoshikimic acid 5-phospho-ribosyl-glycineamide
5-phosphoribosyl-ATP 5-phosphoribosylamine 6,7-dimethyl-8-(1-D-ribityl)lumazine
7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid acetate acetoacetyl-CoA
acetyl-CoA acyl-CoA adenosine
adenosine 3',5'-bismonophosphate adenylo-succinate ADP
AICAR Ala-tRNA(Ala) alpha,alpha-trehalose 6-phosphate
ammonium AMP anthranilate
Arg-tRNA(Arg) Asn-tRNA(Asn) Asp-tRNA(Asp)
ATP bicarbonate but-1-ene-1,2,4-tricarboxylic acid
carbamoyl phosphate carbon dioxide CDP
CDP-diacylglycerol ceramide-1 (C24) ceramide-2 (C24)
ceramide-3 (C24) ceramide-4 (C24) chorismate
cis-aconitate citrate CMP
coenzyme A CTP Cys-tRNA(Cys)
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate D-erythrose 4-phosphate D-fructose 1,6-bisphosphate
D-fructose 6-phosphate D-glucose D-glucose 1-phosphate
D-glucose 6-phosphate D-mannose 1-phosphate D-mannose 6-phosphate
D-ribulose 5-phosphate D-xylulose 5-phosphate dADP
dAMP dATP dCDP
dCMP decanoate decanoyl-CoA
dGDP dGMP diglyceride
dihydrofolic acid dihydroxyacetone phosphate diphosphate
dolichyl D-mannosyl phosphate dolichyl phosphate dTMP
dUMP dUTP episterol
ergosta-5,7,22,24(28)-tetraen-3beta-ol ergosta-5,7,24(28)-trien-3beta-ol ergosterol
ergosterol ester fecosterol ferricytochrome c
ferrocytochrome c formate fumarate
GDP GDP-alpha-D-mannose geranyl diphosphate
Gln-tRNA(Gln) Glu-tRNA(Glu) glutathione
glutathione disulfide Gly-tRNA(Gly) glyceraldehyde 3-phosphate
glycerol 3-phosphate glycogen GMP
GTP His-tRNA(His) homocitrate
homoisocitrate hydrogen peroxide hydrogen sulfide
Ile-tRNA(Ile) IMP inositol-P-ceramide D (C24)
isocitrate isopentenyl diphosphate keto-phenylpyruvate
L-2-aminoadipate L-alanine L-allysine
L-arginine L-asparagine L-aspartate
L-aspartate 4-semialdehyde L-citrulline L-cystathionine
L-cysteine L-glutamate L-glutamine
L-glycine L-histidine L-histidinol
L-histidinol phosphate L-homocysteine L-homoserine
L-isoleucine L-leucine L-lysine
L-methionine L-phenylalanine L-proline
L-saccharopine L-serine L-threonine
L-tryptophan L-tyrosine L-valine
lanosterol laurate lauroyl-CoA
Leu-tRNA(Leu) lignoceric acid Lys-tRNA(Lys)
malonyl-CoA mannan Met-tRNA(Met)
myo-inositol myristate myristoyl-CoA
N(2)-acetyl-L-ornithine N-(5-phospho-beta-D-ribosyl)anthranilate N-acetyl-L-gamma-glutamyl phosphate
N-acetyl-L-glutamate N-carbamoyl-L-aspartate NAD
NADH NADP(+) NADPH
O-acetyl-L-homoserine O-phospho-L-homoserine octanoyl-CoA
ornithine orotate orotidine 5'-(dihydrogen phosphate)
oxaloacetate oxygen palmitate
palmitoyl-CoA Phe-tRNA(Phe) phosphate
phosphatidate phosphatidyl-L-serine phosphatidyl-N,N-dimethylethanolamine
phosphatidyl-N-methylethanolamine phosphatidylcholine phosphatidylethanolamine
phosphoenolpyruvate phosphoribosyl-carboxy-aminoimidazole phosphoribosyl-formamido-carboxamide
phytosphingosine prenyl diphosphate prephenate
Pro-tRNA(Pro) PRPP pyruvate
riboflavin ribose-5-phosphate S-adenosyl-L-homocysteine
S-adenosyl-L-methionine sedoheptulose 7-phosphate Ser-tRNA(Ser)
shikimate sphinganine squalene
stearate stearoyl-CoA sulphate
sulphite THF Thr-tRNA(Thr)
trehalose triglyceride Trp-tRNA(Trp)
Tyr-tRNA(Tyr) ubiquinol-6 ubiquinone-6
UDP UDP-D-glucose UMP
UTP Val-tRNA(Val) xanthosine-5-phosphate
zymosterol zymosterol intermediate 1a zymosterol intermediate 1b
zymosterol intermediate 1c zymosterol intermediate 2 tRNA(Ala)
tRNA(Arg) tRNA(Asn) tRNA(Asp)
tRNA(Cys) tRNA(Gln) tRNA(Glu)
tRNA(Gly) tRNA(His) tRNA(Ile)
tRNA(Leu) tRNA(Lys) tRNA(Met)
tRNA(Phe) tRNA(Pro) tRNA(Ser)
tRNA(Thr) tRNA(Trp) tRNA(Tyr)
tRNA(Val) TRX1 TRX1 disulphide
COX1 COB COX2
COX3 CYS3 PMT2
CDC19 GCV3 GDH3
ADE1 SCT1 ACH1
RIB1 URA7 COR1
PRX1 PRS4 ILS1
IPP1 CDS1 TSC3
MIS1 LYS2 TKL2
GRS1 TPS1 RIB7
TYR1 YPC1 PGI1
PYC2 PDB1 GPX2
HIS7 ARO4 DUT1
RIB5 SHM1 TSC10
ILV6 LEU2 HIS4
GRX1 GLK1 APA1
CIT2 PGK1 FEN1
THR4 TRX3 TSC13
GPD1 SLC1 PSA1
IDP1 COX9 MDH3
NDE2 PMT5 PMT1
LYS21 LYS20 GDH2
TRP1 GCV1 SES1
ARO3 KRS1 TPI1
TGL2 LCB2 TPS2
GRX3 ARO1 HOM2
ADK1 LYS4 DPP1
INM2 SUR2 YDR341C
TRR1 TRP4 KEI1
ADE8 TSA2 GUK1
RIB3 SAM2 GRX2
QCR7 URA3 RIP1
CYC7 PMI40 YND1
FAA2 PRO3 CHO1
SAH1 HOM3 HIS1
ARG5,6 RNR1 SER3
AIM10 TRP2 MET6
PRS2 ADK2 GRX4
PDA1 LPD1 FRS2
SEC53 GSY1 HIS2
MET10 QCR6 HXK1
ERG26 LEU1 ERG4
TRP5 PYC1 MET13
ARO2 LYS5 COX4
COX13 ARO8 ADE5,7
GUS1 HXK2 GSC2
ACB1 ERG25 ADE6
VAS1 ASN2 SKN1
CYS4 CHO2 PSD2
ERG1 RNR4 QCR9
TYS1 TDH3 PDX1
ADE3 SER2 TRX2
PFK1 ENO1 MES1
PRS3 QCR10 ERG11
DIA4 ARG4 DED81
THR1 PUT2 NCP1
INM1 COX6 ERG7
TRR2 DCD1 ENO2
ERG9 BAT1 IMD2
FAA3 DOT5 HIS6
RNR3 SER33 THS1
LYS12 COX5B HIS5
LYS1 HYR1 RNR2
TDH1 BNA3 ARG3
RPE1 URA2 GLG2
INO1 QCR8 ERG20
TDH2 ILV3 CYC1
OPI3 URA8 ADO1
CPA2 STR2 MET5
HOM6 PMT4 BAT2
MET14 AUR1 URA6
GPX1 UGP1 FBA1
YNK1 MDH1 AAT1
PGM1 TGL1 GPM1
PRS1 FAS1 TRP3
URA1 GLG1 GPT2
MTD1 TGL4 YEH1
DPS1 AAT2 ADE16
COX12 TRX1 ERG3
SHM2 FRS1 ALT1
ERG27 AHP1 SAM1
GSY2 MET17 ACO1
FKS1 TAL1 ILV5
ADE13 SUR4 COX8
URA4 IMD3 HMG2
ERG6 IMD4 HMG1
TSL1 URA5 NDI1
ERG13 ERG5 ARG7
PGM2 ILV2 ADE17
NDE1 GCV2 ERG2
PFK2 HFA1 ERG12
GUA1 ERG8 FAA4
COX7 TPS3 PPA2
URA10 SCS7 PGM3
LCB1 ADE4 TGL3
IDP3 IDH1 COX5A
LAT1 LEU4 PSD1
ADE12 YNL247W MET2
ERG24 PHA2 CIT1
ACC1 MVD1 LYS9
ARG1 GPD2 PRS5
MET22 RIB2 WRS1
MDH2 ARG8 RIB4
CYT1 CDC21 TGL5
RKI1 LEU9 ADE2
IDH2 GLN4 ALE1
SER1 HIS3 DFR1
DGA1 CPA1 FAA1
PMT3 ALA1 PYK2
GDH1 MET12 ERG10
GRX5 YDC1 GLR1
IDI1 CDC60 FAS2
FUM1 CIT3 HTS1
GLN1 ARO7 TKL1
GRS2 PIS1 ASN1
KRE6 MET16 DPM1
QCR2 YER152C  
extracellular ammonium carbon dioxide D-glucose
formate oxygen phosphate
sulphate    
Reactions (282)
 
 1,3-beta-glucan synthase [UDP-D-glucose] ↔ [(1->3)-beta-D-glucan] + [UDP];   {FKS1} , {GSC2} , {UDP-D-glucose} , {(1->3)-beta-D-glucan} , {UDP}
 
 1,6-beta-glucan synthase [UDP-D-glucose] ↔ [(1->6)-beta-D-glucan] + [UDP];   {KRE6} , {SKN1} , {UDP-D-glucose} , {(1->6)-beta-D-glucan} , {UDP}
 
 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase [1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide] ↔ [5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide];   {HIS6} , {1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide} , {5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide}
 
 1-acyl-sn-gylcerol-3-phosphate acyltransferase [1-acyl-sn-glycerol 3-phosphate] + [acyl-CoA] ↔ [coenzyme A] + [phosphatidate];   {ALE1} , {SLC1} , {FEN1} , {1-acyl-sn-glycerol 3-phosphate} , {acyl-CoA} , {coenzyme A} , {phosphatidate}
 
 1-pyrroline-5-carboxylate dehydrogenase [L-glutamate] + [NADH] ↔ [1-pyrroline-5-carboxylate] + [NAD];   {PUT2} , {L-glutamate} , {NADH} , {1-pyrroline-5-carboxylate} , {NAD}
 
 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase [2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone] ↔ [5-amino-6-(5-phosphoribitylamino)uracil] + [ammonium];   {RIB2} , {2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone} , {5-amino-6-(5-phosphoribitylamino)uracil} , {ammonium}
 
 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (NADPH) [2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine] + [NADPH] ↔ [2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone] + [NADP(+)];   {RIB7} , {2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine} , {NADPH} , {2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone} , {NADP(+)}
 
 2-aceto-2-hydroxybutanoate synthase [2-oxobutanoate] + [pyruvate] ↔ [(S)-2-acetyl-2-hydroxybutanoate] + [carbon dioxide];   {ILV2} , {ILV6} , {2-oxobutanoate} , {pyruvate} , {(S)-2-acetyl-2-hydroxybutanoate} , {carbon dioxide}
 
 2-aminoadipate transaminase [2-oxoadipic acid] + [L-glutamate] ↔ [2-oxoglutarate] + [L-2-aminoadipate];   {ARO8} , {BNA3} , {YER152C} , {2-oxoadipic acid} , {L-glutamate} , {2-oxoglutarate} , {L-2-aminoadipate}
 
 2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase [D-erythrose 4-phosphate] + [phosphoenolpyruvate] ↔ [7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid] + [phosphate];   {ARO3} , {ARO4} , {D-erythrose 4-phosphate} , {phosphoenolpyruvate} , {7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid} , {phosphate}
 
 2-isopropylmalate hydratase [2-isopropylmalate] ↔ [2-isopropylmaleic acid];   {LEU1} , {2-isopropylmalate} , {2-isopropylmaleic acid}
 
 2-isopropylmalate synthase [3-methyl-2-oxobutanoate] + [acetyl-CoA] ↔ [2-isopropylmalate] + [coenzyme A];   {LEU4} , {LEU9} , {3-methyl-2-oxobutanoate} , {acetyl-CoA} , {2-isopropylmalate} , {coenzyme A}
 
 2-methylcitrate dehydratase [homocitrate] ↔ [but-1-ene-1,2,4-tricarboxylic acid];   {LYS4} , {homocitrate} , {but-1-ene-1,2,4-tricarboxylic acid}
 
 2-oxo-4-methyl-3-carboxypentanoate decarboxylation [(2S)-2-isopropyl-3-oxosuccinate] ↔ [4-methyl-2-oxopentanoate] + [carbon dioxide];   {BAT2} , {BAT1} , {(2S)-2-isopropyl-3-oxosuccinate} , {4-methyl-2-oxopentanoate} , {carbon dioxide}
 
 3',5'-bisphosphate nucleotidase [adenosine 3',5'-bismonophosphate] ↔ [AMP] + [phosphate];   {MET22} , {adenosine 3',5'-bismonophosphate} , {AMP} , {phosphate}
 
 3,4-dihydroxy-2-butanone-4-phosphate synthase [D-ribulose 5-phosphate] ↔ [2-hydroxy-3-oxobutyl phosphate] + [formate];   {RIB3} , {D-ribulose 5-phosphate} , {2-hydroxy-3-oxobutyl phosphate} , {formate}
 
 3-dehydroquinate dehydratase [3-dehydroquinate] ↔ [3-dehydroshikimate];   {ARO1} , {3-dehydroquinate} , {3-dehydroshikimate}
 
 3-dehydroquinate synthase [7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid] ↔ [3-dehydroquinate] + [phosphate];   {ARO1} , {7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid} , {3-dehydroquinate} , {phosphate}
 
 3-dehydrosphinganine reductase [3-ketosphinganine] + [NADPH] ↔ [NADP(+)] + [sphinganine];   {TSC10} , {3-ketosphinganine} , {NADPH} , {NADP(+)} , {sphinganine}
 
 3-isopropylmalate dehydratase [2-isopropylmaleic acid] ↔ [(2R,3S)-3-isopropylmalate];   {LEU1} , {2-isopropylmaleic acid} , {(2R,3S)-3-isopropylmalate}
 
 3-isopropylmalate dehydrogenase [(2R,3S)-3-isopropylmalate] + [NAD] ↔ [(2S)-2-isopropyl-3-oxosuccinate] + [NADH];   {LEU2} , {(2R,3S)-3-isopropylmalate} , {NAD} , {(2S)-2-isopropyl-3-oxosuccinate} , {NADH}
 
 3-phosphoshikimate 1-carboxyvinyltransferase [3-phosphoshikimic acid] + [phosphoenolpyruvate] ↔ [5-O-(1-carboxyvinyl)-3-phosphoshikimic acid] + [phosphate];   {ARO1} , {3-phosphoshikimic acid} , {phosphoenolpyruvate} , {5-O-(1-carboxyvinyl)-3-phosphoshikimic acid} , {phosphate}
 
 5'-phosphoribosylformyl glycinamidine synthetase [5'-phosphoribosyl-N-formylglycineamide] + [ATP] + [L-glutamine] ↔ [5'-phosphoribosyl-N-formylglycineamidine] + [ADP] + [L-glutamate] + [phosphate];   {ADE6} , {5'-phosphoribosyl-N-formylglycineamide} , {ATP} , {L-glutamine} , {5'-phosphoribosyl-N-formylglycineamidine} , {ADP} , {L-glutamate} , {phosphate}
 
 5,10-methylenetetrahydrofolate reductase (NADPH) [5,10-methylenetetrahydrofolate] + [NADPH] ↔ [5-methyltetrahydrofolate] + [NADP(+)];   {MET13} , {MET12} , {5,10-methylenetetrahydrofolate} , {NADPH} , {5-methyltetrahydrofolate} , {NADP(+)}
 
 acetohydroxy acid isomeroreductase [2-acetyllactic acid] + [NADPH] ↔ [(R)-2,3-dihydroxy-3-methylbutanoate] + [NADP(+)];   {ILV5} , {2-acetyllactic acid} , {NADPH} , {(R)-2,3-dihydroxy-3-methylbutanoate} , {NADP(+)}
 
 acetolactate synthase 2.0 × [pyruvate] ↔ [2-acetyllactic acid] + [carbon dioxide];   {ILV2} , {ILV6} , {pyruvate} , {2-acetyllactic acid} , {carbon dioxide}
 
 acetyl-CoA C-acetyltransferase 2.0 × [acetyl-CoA] ↔ [acetoacetyl-CoA] + [coenzyme A];   {ERG10} , {acetyl-CoA} , {acetoacetyl-CoA} , {coenzyme A}
 
 acetyl-Coa carboxylase [acetyl-CoA] + [ATP] + [bicarbonate] ↔ [ADP] + [malonyl-CoA] + [phosphate];   {HFA1} , {ACC1} , {acetyl-CoA} , {ATP} , {bicarbonate} , {ADP} , {malonyl-CoA} , {phosphate}
 
 acetyl-CoA hydrolase [acetate] + [coenzyme A] ↔ [acetyl-CoA];   {ACH1} , {acetate} , {coenzyme A} , {acetyl-CoA}
 
 acetylglutamate kinase [ATP] + [N-acetyl-L-glutamate] ↔ [ADP] + [N-acetyl-L-gamma-glutamyl phosphate];   {ARG5,6} , {ATP} , {N-acetyl-L-glutamate} , {ADP} , {N-acetyl-L-gamma-glutamyl phosphate}
 
 acteylornithine transaminase [2-acetamido-5-oxopentanoate] + [L-glutamate] ↔ [2-oxoglutarate] + [N(2)-acetyl-L-ornithine];   {ARG8} , {2-acetamido-5-oxopentanoate} , {L-glutamate} , {2-oxoglutarate} , {N(2)-acetyl-L-ornithine}
 
 adenosine kinase [adenosine] + [ATP] ↔ [ADP] + [AMP];   {ADO1} , {adenosine} , {ATP} , {ADP} , {AMP}
 
 adenosylhomocysteinase [S-adenosyl-L-homocysteine] ↔ [adenosine] + [L-homocysteine];   {SAH1} , {S-adenosyl-L-homocysteine} , {adenosine} , {L-homocysteine}
 
 adenylate kinase [AMP] + [ATP] ↔ 2.0 × [ADP];   {ADK1} , {ADK2} , {AMP} , {ATP} , {ADP}
 
 adenylosuccinate lyase (AICAR) [5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole] ↔ [AICAR] + [fumarate];   {ADE13} , {5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole} , {AICAR} , {fumarate}
 
 adenylosuccinate lyase [adenylo-succinate] ↔ [AMP] + [fumarate];   {ADE13} , {adenylo-succinate} , {AMP} , {fumarate}
 
 adenylosuccinate synthase [GTP] + [IMP] + [L-aspartate] ↔ [adenylo-succinate] + [GDP] + [phosphate];   {ADE12} , {GTP} , {IMP} , {L-aspartate} , {adenylo-succinate} , {GDP} , {phosphate}
 
 adenylyl-sulfate kinase [5'-adenylyl sulfate] + [ATP] ↔ [3'-phospho-5'-adenylyl sulfate] + [ADP];   {MET14} , {5'-adenylyl sulfate} , {ATP} , {3'-phospho-5'-adenylyl sulfate} , {ADP}
 
 alanyl-tRNA synthetase [ATP] + [L-alanine] + [tRNA(Ala)] ↔ [Ala-tRNA(Ala)] + [AMP] + [diphosphate];   {ALA1} , {ATP} , {L-alanine} , {tRNA(Ala)} , {Ala-tRNA(Ala)} , {AMP} , {diphosphate}
 
 alpha,alpha-trehalose-phosphate synthase (UDP-forming) [D-glucose 6-phosphate] + [UDP-D-glucose] ↔ [alpha,alpha-trehalose 6-phosphate] + [UDP];   {TSL1} , {TPS1} , {TPS2} , {TPS3} , {D-glucose 6-phosphate} , {UDP-D-glucose} , {alpha,alpha-trehalose 6-phosphate} , {UDP}
 
 anthranilate phosphoribosyltransferase [anthranilate] + [PRPP] ↔ [diphosphate] + [N-(5-phospho-beta-D-ribosyl)anthranilate];   {TRP4} , {anthranilate} , {PRPP} , {diphosphate} , {N-(5-phospho-beta-D-ribosyl)anthranilate}
 
 anthranilate synthase [chorismate] + [L-glutamine] ↔ [anthranilate] + [L-glutamate] + [pyruvate];   {TRP2} , {TRP3} , {chorismate} , {L-glutamine} , {anthranilate} , {L-glutamate} , {pyruvate}
 
 argininosuccinate lyase [(N(omega)-L-arginino)succinic acid] ↔ [fumarate] + [L-arginine];   {ARG4} , {(N(omega)-L-arginino)succinic acid} , {fumarate} , {L-arginine}
 
 argininosuccinate synthase [ATP] + [L-aspartate] + [L-citrulline] ↔ [(N(omega)-L-arginino)succinic acid] + [AMP] + [diphosphate];   {ARG1} , {ATP} , {L-aspartate} , {L-citrulline} , {(N(omega)-L-arginino)succinic acid} , {AMP} , {diphosphate}
 
 arginyl-tRNA synthetase [ATP] + [L-arginine] + [tRNA(Arg)] ↔ [AMP] + [Arg-tRNA(Arg)] + [diphosphate];   {YDR341C} , {ATP} , {L-arginine} , {tRNA(Arg)} , {AMP} , {Arg-tRNA(Arg)} , {diphosphate}
 
 asparagine synthase (glutamine-hydrolysing) [ATP] + [L-aspartate] + [L-glutamine] ↔ [AMP] + [diphosphate] + [L-asparagine] + [L-glutamate];   {ASN1} , {ASN2} , {ATP} , {L-aspartate} , {L-glutamine} , {AMP} , {diphosphate} , {L-asparagine} , {L-glutamate}
 
 Asparaginyl-tRNA synthetase [ATP] + [L-asparagine] + [tRNA(Asn)] ↔ [AMP] + [Asn-tRNA(Asn)] + [diphosphate];   {DED81} , {ATP} , {L-asparagine} , {tRNA(Asn)} , {AMP} , {Asn-tRNA(Asn)} , {diphosphate}
 
 aspartate carbamoyltransferase [carbamoyl phosphate] + [L-aspartate] ↔ [N-carbamoyl-L-aspartate] + [phosphate];   {URA2} , {carbamoyl phosphate} , {L-aspartate} , {N-carbamoyl-L-aspartate} , {phosphate}
 
 aspartate kinase [ATP] + [L-aspartate] ↔ [4-phospho-L-aspartate] + [ADP];   {HOM3} , {ATP} , {L-aspartate} , {4-phospho-L-aspartate} , {ADP}
 
 aspartate transaminase [L-glutamate] + [oxaloacetate] ↔ [2-oxoglutarate] + [L-aspartate];   {AAT2} , {AAT1} , {L-glutamate} , {oxaloacetate} , {2-oxoglutarate} , {L-aspartate}
 
 aspartate-semialdehyde dehydrogenase [4-phospho-L-aspartate] + [NADPH] ↔ [L-aspartate 4-semialdehyde] + [NADP(+)] + [phosphate];   {HOM2} , {4-phospho-L-aspartate} , {NADPH} , {L-aspartate 4-semialdehyde} , {NADP(+)} , {phosphate}
 
 Aspartyl-tRNA synthetase [ATP] + [L-aspartate] + [tRNA(Asp)] ↔ [AMP] + [Asp-tRNA(Asp)] + [diphosphate];   {DPS1} , {ATP} , {L-aspartate} , {tRNA(Asp)} , {AMP} , {Asp-tRNA(Asp)} , {diphosphate}
 
 ATP phosphoribosyltransferase [ATP] + [PRPP] ↔ [5-phosphoribosyl-ATP] + [diphosphate];   {HIS1} , {ATP} , {PRPP} , {5-phosphoribosyl-ATP} , {diphosphate}
 
 C-14 sterol reductase [4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol] + [NADPH] ↔ [14-demethyllanosterol] + [NADP(+)];   {ERG24} , {4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol} , {NADPH} , {14-demethyllanosterol} , {NADP(+)}
 
 C-22 sterol desaturase (NADP) [ergosta-5,7,24(28)-trien-3beta-ol] + [NADPH] + [oxygen] ↔ [ergosta-5,7,22,24(28)-tetraen-3beta-ol] + [NADP(+)];   {ERG5} , {ergosta-5,7,24(28)-trien-3beta-ol} , {NADPH} , {oxygen} , {ergosta-5,7,22,24(28)-tetraen-3beta-ol} , {NADP(+)}
 
 C-3 sterol dehydrogenase [NADP(+)] + [zymosterol intermediate 1c] ↔ [carbon dioxide] + [NADPH] + [zymosterol intermediate 2];   {ERG26} , {NADP(+)} , {zymosterol intermediate 1c} , {carbon dioxide} , {NADPH} , {zymosterol intermediate 2}
 
 C-3 sterol dehydrogenase (4-methylzymosterol) [4beta-methylzymosterol-4alpha-carboxylic acid] + [NAD] ↔ [3-dehydro-4-methylzymosterol] + [carbon dioxide] + [NADH];   {ERG26} , {4beta-methylzymosterol-4alpha-carboxylic acid} , {NAD} , {3-dehydro-4-methylzymosterol} , {carbon dioxide} , {NADH}
 
 C-3 sterol keto reductase (4-methylzymosterol) [3-dehydro-4-methylzymosterol] + [NADPH] ↔ [4alpha-methylzymosterol] + [NADP(+)];   {ERG27} , {3-dehydro-4-methylzymosterol} , {NADPH} , {4alpha-methylzymosterol} , {NADP(+)}
 
 C-3 sterol keto reductase (zymosterol) [NADPH] + [zymosterol intermediate 2] ↔ [NADP(+)] + [zymosterol];   {ERG27} , {NADPH} , {zymosterol intermediate 2} , {NADP(+)} , {zymosterol}
 
 C-4 methyl sterol oxidase [4alpha-methylzymosterol] + [NADPH] + [oxygen] ↔ [NADP(+)] + [zymosterol intermediate 1a];   {ERG25} , {4alpha-methylzymosterol} , {NADPH} , {oxygen} , {NADP(+)} , {zymosterol intermediate 1a}
 
 C-4 methyl sterol oxidase [NADPH] + [oxygen] + [zymosterol intermediate 1a] ↔ [NADP(+)] + [zymosterol intermediate 1b];   {ERG25} , {NADPH} , {oxygen} , {zymosterol intermediate 1a} , {NADP(+)} , {zymosterol intermediate 1b}
 
 C-4 methyl sterol oxidase [NADPH] + [oxygen] + [zymosterol intermediate 1b] ↔ [NADP(+)] + [zymosterol intermediate 1c];   {ERG25} , {NADPH} , {oxygen} , {zymosterol intermediate 1b} , {NADP(+)} , {zymosterol intermediate 1c}
 
 C-4 sterol methyl oxidase (4,4-dimethylzymosterol) [14-demethyllanosterol] + 3.0 × [NADPH] + 3.0 × [oxygen] ↔ [4beta-methylzymosterol-4alpha-carboxylic acid] + 3.0 × [NADP(+)];   {ERG25} , {14-demethyllanosterol} , {NADPH} , {oxygen} , {4beta-methylzymosterol-4alpha-carboxylic acid} , {NADP(+)}
 
 C-5 sterol desaturase [episterol] + [NADPH] + [oxygen] ↔ [ergosta-5,7,24(28)-trien-3beta-ol] + [NADP(+)];   {ERG3} , {episterol} , {NADPH} , {oxygen} , {ergosta-5,7,24(28)-trien-3beta-ol} , {NADP(+)}
 
 C-8 sterol isomerase [fecosterol] ↔ [episterol];   {ERG2} , {fecosterol} , {episterol}
 
 C-s24 sterol reductase [ergosta-5,7,22,24(28)-tetraen-3beta-ol] + [NADPH] ↔ [ergosterol] + [NADP(+)];   {ERG4} , {ergosta-5,7,22,24(28)-tetraen-3beta-ol} , {NADPH} , {ergosterol} , {NADP(+)}
 
 carbamoyl-phosphate synthase (glutamine-hydrolysing) 2.0 × [ATP] + [bicarbonate] + [L-glutamine] ↔ 2.0 × [ADP] + [carbamoyl phosphate] + [L-glutamate] + [phosphate];   {URA2} , {CPA2} , {CPA1} , {ATP} , {bicarbonate} , {L-glutamine} , {ADP} , {carbamoyl phosphate} , {L-glutamate} , {phosphate}
 
 CDP-diacylglycerol synthase [CTP] + [phosphatidate] ↔ [CDP-diacylglycerol] + [diphosphate];   {CDS1} , {CTP} , {phosphatidate} , {CDP-diacylglycerol} , {diphosphate}
 
 ceramide-1 hydroxylase (24C) [ceramide-1 (C24)] + [NADPH] + [oxygen] ↔ [ceramide-2 (C24)] + [NADP(+)];   {SUR2} , {ceramide-1 (C24)} , {NADPH} , {oxygen} , {ceramide-2 (C24)} , {NADP(+)}
 
 ceramide-3 synthase (24C) [ceramide-2 (C24)] + [NADPH] + [oxygen] ↔ [ceramide-3 (C24)] + [NADP(+)];   {SCS7} , {ceramide-2 (C24)} , {NADPH} , {oxygen} , {ceramide-3 (C24)} , {NADP(+)}
 
 ceramide-4 synthase (24C) [ceramide-3 (C24)] + [NADPH] + [oxygen] ↔ [ceramide-4 (C24)] + [NADP(+)];   {SCS7} , {ceramide-3 (C24)} , {NADPH} , {oxygen} , {ceramide-4 (C24)} , {NADP(+)}
 
 chorismate mutase [chorismate] ↔ [prephenate];   {ARO7} , {chorismate} , {prephenate}
 
 chorismate synthase [5-O-(1-carboxyvinyl)-3-phosphoshikimic acid] ↔ [chorismate] + [phosphate];   {ARO2} , {5-O-(1-carboxyvinyl)-3-phosphoshikimic acid} , {chorismate} , {phosphate}
 
 cis-aconitate(3-) to isocitrate [cis-aconitate] ↔ [isocitrate];   {ACO1} , {cis-aconitate} , {isocitrate}
 
 citrate synthase [acetyl-CoA] + [oxaloacetate] ↔ [citrate] + [coenzyme A];   {CIT3} , {CIT1} , {CIT2} , {acetyl-CoA} , {oxaloacetate} , {citrate} , {coenzyme A}
 
 citrate to cis-aconitate(3-) [citrate] ↔ [cis-aconitate];   {ACO1} , {citrate} , {cis-aconitate}
 
 CTP synthase (NH3) [ammonium] + [ATP] + [UTP] ↔ [ADP] + [CTP] + [phosphate];   {URA8} , {URA7} , {ammonium} , {ATP} , {UTP} , {ADP} , {CTP} , {phosphate}
 
 cystathionine beta-synthase [L-homocysteine] + [L-serine] ↔ [L-cystathionine];   {CYS4} , {L-homocysteine} , {L-serine} , {L-cystathionine}
 
 cystathionine g-lyase [L-cystathionine] ↔ [2-oxobutanoate] + [ammonium] + [L-cysteine];   {CYS3} , {L-cystathionine} , {2-oxobutanoate} , {ammonium} , {L-cysteine}
 
 cystathionine gamma-synthase [L-cysteine] + [O-acetyl-L-homoserine] ↔ [acetate] + [L-cystathionine];   {STR2} , {L-cysteine} , {O-acetyl-L-homoserine} , {acetate} , {L-cystathionine}
 
 cysteinyl-tRNA synthetase [ATP] + [L-cysteine] + [tRNA(Cys)] ↔ [AMP] + [Cys-tRNA(Cys)] + [diphosphate];   {YNL247W} , {ATP} , {L-cysteine} , {tRNA(Cys)} , {AMP} , {Cys-tRNA(Cys)} , {diphosphate}
 
 cytochrome P450 lanosterol 14-alpha-demethylase (NADP) [lanosterol] + 3.0 × [NADPH] + 3.0 × [oxygen] ↔ [4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol] + [formate] + 3.0 × [NADP(+)];   {NCP1} , {ERG11} , {lanosterol} , {NADPH} , {oxygen} , {4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol} , {formate} , {NADP(+)}
 
 dCMP deaminase [dCMP] ↔ [ammonium] + [dUMP];   {DCD1} , {dCMP} , {ammonium} , {dUMP}
 
 deoxyguanylate kinase (dGMP:ATP) [ADP] + [dGDP] ↔ [ATP] + [dGMP];   {GUK1} , {ADP} , {dGDP} , {ATP} , {dGMP}
 
 diacylglycerol acyltransferase [coenzyme A] + [triglyceride] ↔ [acyl-CoA] + [diglyceride];   {DGA1} , {coenzyme A} , {triglyceride} , {acyl-CoA} , {diglyceride}
 
 diacylglycerol pyrophosphate phosphatase [phosphatidate] ↔ [diglyceride] + [phosphate];   {DPP1} , {phosphatidate} , {diglyceride} , {phosphate}
 
 dihydoorotic acid dehydrogenase [(S)-dihydroorotate] + [oxygen] ↔ [hydrogen peroxide] + [orotate];   {URA1} , {(S)-dihydroorotate} , {oxygen} , {hydrogen peroxide} , {orotate}
 
 dihydroceramidase [lignoceric acid] + [sphinganine] ↔ [ceramide-1 (C24)];   {YDC1} , {lignoceric acid} , {sphinganine} , {ceramide-1 (C24)}
 
 dihydrofolate reductase [dihydrofolic acid] + [NADPH] ↔ [NADP(+)] + [THF];   {DFR1} , {dihydrofolic acid} , {NADPH} , {NADP(+)} , {THF}
 
 dihydroorotase [N-carbamoyl-L-aspartate] ↔ [(S)-dihydroorotate];   {URA4} , {N-carbamoyl-L-aspartate} , {(S)-dihydroorotate}
 
 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) [(R)-2,3-dihydroxy-3-methylbutanoate] ↔ [3-methyl-2-oxobutanoate];   {ILV3} , {(R)-2,3-dihydroxy-3-methylbutanoate} , {3-methyl-2-oxobutanoate}
 
 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) [(2R,3R)-2,3-dihydroxy-3-methylpentanoate] ↔ [(S)-3-methyl-2-oxopentanoate];   {ILV3} , {(2R,3R)-2,3-dihydroxy-3-methylpentanoate} , {(S)-3-methyl-2-oxopentanoate}
 
 dimethylallyltranstransferase [isopentenyl diphosphate] + [prenyl diphosphate] ↔ [diphosphate] + [geranyl diphosphate];   {ERG20} , {isopentenyl diphosphate} , {prenyl diphosphate} , {diphosphate} , {geranyl diphosphate}
 
 dolichyl-phosphate D-mannosyltransferase [dolichyl phosphate] + [GDP-alpha-D-mannose] ↔ [dolichyl D-mannosyl phosphate] + [GDP];   {DPM1} , {dolichyl phosphate} , {GDP-alpha-D-mannose} , {dolichyl D-mannosyl phosphate} , {GDP}
 
 dolichyl-phosphate-mannose--protein mannosyltransferase [dolichyl D-mannosyl phosphate] ↔ [dolichyl phosphate] + [mannan];   {PMT5} , {PMT4} , {PMT2} , {PMT3} , {PMT1} , {dolichyl D-mannosyl phosphate} , {dolichyl phosphate} , {mannan}
 
 dUTP diphosphatase [dUTP] ↔ [diphosphate] + [dUMP];   {DUT1} , {dUTP} , {diphosphate} , {dUMP}
 
 enolase [2-phospho-D-glyceric acid] ↔ [phosphoenolpyruvate];   {ENO1} , {ENO2} , {2-phospho-D-glyceric acid} , {phosphoenolpyruvate}
 
 fatty acid synthase (n-C12:0) [decanoate] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [laurate] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {decanoate} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {laurate} , {NADP(+)}
 
 fatty acid synthase (n-C14:0) [laurate] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [myristate] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {laurate} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {myristate} , {NADP(+)}
 
 fatty acid synthase (n-C16:0) [malonyl-CoA] + [myristate] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [palmitate];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {myristate} , {NADPH} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {palmitate}
 
 fatty acid synthase (n-C18:0) [malonyl-CoA] + 2.0 × [NADPH] + [palmitate] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [stearate];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {NADPH} , {palmitate} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {stearate}
 
 fatty acid synthase (n-C24:0), lumped reaction 3.0 × [malonyl-CoA] + 6.0 × [NADPH] + [stearate] ↔ 3.0 × [carbon dioxide] + 3.0 × [coenzyme A] + [lignoceric acid] + 6.0 × [NADP(+)];   {TSC13} , {FEN1} , {SUR4} , {malonyl-CoA} , {NADPH} , {stearate} , {carbon dioxide} , {coenzyme A} , {lignoceric acid} , {NADP(+)}
 
 fatty acyl-CoA synthase (n-C10:0CoA) [malonyl-CoA] + 2.0 × [NADPH] + [octanoyl-CoA] ↔ [carbon dioxide] + [coenzyme A] + [decanoyl-CoA] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {NADPH} , {octanoyl-CoA} , {carbon dioxide} , {coenzyme A} , {decanoyl-CoA} , {NADP(+)}
 
 fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction [acetyl-CoA] + 3.0 × [malonyl-CoA] + 6.0 × [NADPH] ↔ 3.0 × [carbon dioxide] + 3.0 × [coenzyme A] + 6.0 × [NADP(+)] + [octanoyl-CoA];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {acetyl-CoA} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {octanoyl-CoA}
 
 fatty-acid--CoA ligase (decanoate) [AMP] + [decanoyl-CoA] + [diphosphate] ↔ [ATP] + [coenzyme A] + [decanoate];   {FAA2} , {AMP} , {decanoyl-CoA} , {diphosphate} , {ATP} , {coenzyme A} , {decanoate}
 
 fatty-acid--CoA ligase (dodecanoate) [AMP] + [diphosphate] + [lauroyl-CoA] ↔ [ATP] + [coenzyme A] + [laurate];   {FAA2} , {AMP} , {diphosphate} , {lauroyl-CoA} , {ATP} , {coenzyme A} , {laurate}
 
 fatty-acid--CoA ligase (octadecanoate) [AMP] + [diphosphate] + [stearoyl-CoA] ↔ [ATP] + [coenzyme A] + [stearate];   {FAA4} , {FAA1} , {FAA3} , {AMP} , {diphosphate} , {stearoyl-CoA} , {ATP} , {coenzyme A} , {stearate}
 
 fatty-acyl-CoA synthase (n-C12:0CoA) [decanoyl-CoA] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [lauroyl-CoA] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {decanoyl-CoA} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {lauroyl-CoA} , {NADP(+)}
 
 fatty-acyl-CoA synthase (n-C14:0CoA) [lauroyl-CoA] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [myristoyl-CoA] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {lauroyl-CoA} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {myristoyl-CoA} , {NADP(+)}
 
 fatty-acyl-CoA synthase (n-C16:0CoA) [malonyl-CoA] + [myristoyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [palmitoyl-CoA];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {myristoyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {palmitoyl-CoA}
 
 fatty-acyl-CoA synthase (n-C18:0CoA) [malonyl-CoA] + 2.0 × [NADPH] + [palmitoyl-CoA] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [stearoyl-CoA];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {NADPH} , {palmitoyl-CoA} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {stearoyl-CoA}
 
 ferrocytochrome-c:oxygen oxidoreductase 4.0 × [ferrocytochrome c] + [oxygen] ↔ 4.0 × [ferricytochrome c];   {COX12} , {COX3} , {COX5A} , {COX6} , {COX9} , {COX1} , {COX13} , {CYC7} , {COX7} , {COX8} , {COX2} , {CYC1} , {COX4} , {COX5B} , {ferrocytochrome c} , {oxygen} , {ferricytochrome c}
 
 ferrocytochrome-c:oxygen oxidoreductase 2.0 × [ferricytochrome c] + [ubiquinol-6] ↔ 2.0 × [ferrocytochrome c] + [ubiquinone-6];   {QCR8} , {QCR2} , {QCR10} , {RIP1} , {COB} , {QCR7} , {QCR9} , {CYC7} , {CYT1} , {COR1} , {CYC1} , {QCR6} , {ferricytochrome c} , {ubiquinol-6} , {ferrocytochrome c} , {ubiquinone-6}
 
 formate-tetrahydrofolate ligase [10-formyl-THF] + [ADP] + [phosphate] ↔ [ATP] + [formate] + [THF];   {ADE3} , {MIS1} , {10-formyl-THF} , {ADP} , {phosphate} , {ATP} , {formate} , {THF}
 
 fructose-bisphosphate aldolase [D-fructose 1,6-bisphosphate] ↔ [dihydroxyacetone phosphate] + [glyceraldehyde 3-phosphate];   {FBA1} , {D-fructose 1,6-bisphosphate} , {dihydroxyacetone phosphate} , {glyceraldehyde 3-phosphate}
 
 fumarase [fumarate] ↔ [(S)-malate];   {FUM1} , {fumarate} , {(S)-malate}
 
 geranyltranstransferase [geranyl diphosphate] + [isopentenyl diphosphate] ↔ [farnesyl diphosphate] + [diphosphate];   {ERG20} , {geranyl diphosphate} , {isopentenyl diphosphate} , {farnesyl diphosphate} , {diphosphate}
 
 glucose-6-phosphate isomerase [D-glucose 6-phosphate] ↔ [D-fructose 6-phosphate];   {PGI1} , {D-glucose 6-phosphate} , {D-fructose 6-phosphate}
 
 glutamate dehydrogenase (NAD) [2-oxoglutarate] + [ammonium] + [NADH] ↔ [L-glutamate] + [NAD];   {GDH2} , {2-oxoglutarate} , {ammonium} , {NADH} , {L-glutamate} , {NAD}
 
 glutamate dehydrogenase (NADP) [2-oxoglutarate] + [ammonium] + [NADPH] ↔ [L-glutamate] + [NADP(+)];   {GDH3} , {GDH1} , {2-oxoglutarate} , {ammonium} , {NADPH} , {L-glutamate} , {NADP(+)}
 
 glutamine synthetase [ammonium] + [ATP] + [L-glutamate] ↔ [ADP] + [L-glutamine] + [phosphate];   {GLN1} , {ammonium} , {ATP} , {L-glutamate} , {ADP} , {L-glutamine} , {phosphate}
 
 glutaminyl-tRNA synthetase [ATP] + [L-glutamine] + [tRNA(Gln)] ↔ [AMP] + [diphosphate] + [Gln-tRNA(Gln)];   {GLN4} , {ATP} , {L-glutamine} , {tRNA(Gln)} , {AMP} , {diphosphate} , {Gln-tRNA(Gln)}
 
 glutamyl-tRNA synthetase [ATP] + [L-glutamate] + [tRNA(Glu)] ↔ [AMP] + [diphosphate] + [Glu-tRNA(Glu)];   {GUS1} , {ATP} , {L-glutamate} , {tRNA(Glu)} , {AMP} , {diphosphate} , {Glu-tRNA(Glu)}
 
 glutathione oxidoreductase [glutathione disulfide] + [NADPH] ↔ 2.0 × [glutathione] + [NADP(+)];   {GRX2} , {GRX1} , {GRX3} , {GRX4} , {GLR1} , {GRX5} , {glutathione disulfide} , {NADPH} , {glutathione} , {NADP(+)}
 
 glutathione peridoxase 2.0 × [glutathione] + [hydrogen peroxide] ↔ [glutathione disulfide];   {GRX2} , {GPX1} , {GPX2} , {GRX1} , {HYR1} , {GRX5} , {glutathione} , {hydrogen peroxide} , {glutathione disulfide}
 
 glyceraldehyde-3-phosphate dehydrogenase [glyceraldehyde 3-phosphate] + [NAD] + [phosphate] ↔ [1,3-bisphospho-D-glycerate] + [NADH];   {TDH3} , {TDH1} , {TDH2} , {glyceraldehyde 3-phosphate} , {NAD} , {phosphate} , {1,3-bisphospho-D-glycerate} , {NADH}
 
 glycerol-3-phosphate dehydrogenase (NAD) [dihydroxyacetone phosphate] + [NADH] ↔ [glycerol 3-phosphate] + [NAD];   {GPD1} , {GPD2} , {dihydroxyacetone phosphate} , {NADH} , {glycerol 3-phosphate} , {NAD}
 
 glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase [acyl-CoA] + [glycerol 3-phosphate] ↔ [1-acyl-sn-glycerol 3-phosphate] + [coenzyme A];   {SCT1} , {GPT2} , {acyl-CoA} , {glycerol 3-phosphate} , {1-acyl-sn-glycerol 3-phosphate} , {coenzyme A}
 
 glycinamide ribotide transformylase [10-formyl-THF] + [5-phospho-ribosyl-glycineamide] ↔ [5'-phosphoribosyl-N-formylglycineamide] + [THF];   {ADE8} , {10-formyl-THF} , {5-phospho-ribosyl-glycineamide} , {5'-phosphoribosyl-N-formylglycineamide} , {THF}
 
 glycine cleavage system [L-glycine] + [NAD] + [THF] ↔ [5,10-methylenetetrahydrofolate] + [ammonium] + [carbon dioxide] + [NADH];   {GCV2} , {GCV3} , {GCV1} , {LPD1} , {L-glycine} , {NAD} , {THF} , {5,10-methylenetetrahydrofolate} , {ammonium} , {carbon dioxide} , {NADH}
 
 glycine hydroxymethyltransferase [L-serine] + [THF] ↔ [5,10-methylenetetrahydrofolate] + [L-glycine];   {SHM2} , {SHM1} , {L-serine} , {THF} , {5,10-methylenetetrahydrofolate} , {L-glycine}
 
 glycogen (starch) synthase [UDP-D-glucose] ↔ [glycogen] + [UDP];   {GSY2} , {GLG2} , {GSY1} , {GLG1} , {UDP-D-glucose} , {glycogen} , {UDP}
 
 glycyl-tRNA synthetase [ATP] + [L-glycine] + [tRNA(Gly)] ↔ [AMP] + [diphosphate] + [Gly-tRNA(Gly)];   {GRS1} , {GRS2} , {ATP} , {L-glycine} , {tRNA(Gly)} , {AMP} , {diphosphate} , {Gly-tRNA(Gly)}
 
 GMP synthase [ATP] + [L-glutamine] + [xanthosine-5-phosphate] ↔ [AMP] + [diphosphate] + [GMP] + [L-glutamate];   {GUA1} , {ATP} , {L-glutamine} , {xanthosine-5-phosphate} , {AMP} , {diphosphate} , {GMP} , {L-glutamate}
 
 GTP cyclohydrolase II [GTP] ↔ [2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine] + [diphosphate] + [formate];   {RIB1} , {GTP} , {2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine} , {diphosphate} , {formate}
 
 guanylate kinase [ATP] + [GMP] ↔ [ADP] + [GDP];   {GUK1} , {ATP} , {GMP} , {ADP} , {GDP}
 
 guanylate kinase (GMP:dATP) [dATP] + [GMP] ↔ [dADP] + [GDP];   {GUK1} , {dATP} , {GMP} , {dADP} , {GDP}
 
 hexokinase (D-glucose:ATP) [ATP] + [D-glucose] ↔ [ADP] + [D-glucose 6-phosphate];   {GLK1} , {HXK1} , {HXK2} , {ATP} , {D-glucose} , {ADP} , {D-glucose 6-phosphate}
 
 histidinol dehydrogenase [L-histidinol] + 2.0 × [NAD] ↔ [L-histidine] + 2.0 × [NADH];   {HIS4} , {L-histidinol} , {NAD} , {L-histidine} , {NADH}
 
 histidinol-phosphatase [L-histidinol phosphate] ↔ [L-histidinol] + [phosphate];   {HIS2} , {L-histidinol phosphate} , {L-histidinol} , {phosphate}
 
 histidinol-phosphate transaminase [3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-histidinol phosphate];   {HIS5} , {3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate} , {L-glutamate} , {2-oxoglutarate} , {L-histidinol phosphate}
 
 histidyl-tRNA synthetase [ATP] + [L-histidine] + [tRNA(His)] ↔ [AMP] + [diphosphate] + [His-tRNA(His)];   {HTS1} , {ATP} , {L-histidine} , {tRNA(His)} , {AMP} , {diphosphate} , {His-tRNA(His)}
 
 homoacontinate hydratase [but-1-ene-1,2,4-tricarboxylic acid] ↔ [homoisocitrate];   {LYS4} , {but-1-ene-1,2,4-tricarboxylic acid} , {homoisocitrate}
 
 homocitrate synthase [2-oxoglutarate] + [acetyl-CoA] ↔ [coenzyme A] + [homocitrate];   {LYS20} , {LYS21} , {2-oxoglutarate} , {acetyl-CoA} , {coenzyme A} , {homocitrate}
 
 homoisocitrate dehydrogenase [homoisocitrate] + [NAD] ↔ [2-oxoadipic acid] + [NADH] + [carbon dioxide];   {LYS12} , {homoisocitrate} , {NAD} , {2-oxoadipic acid} , {NADH} , {carbon dioxide}
 
 homoserine dehydrogenase (NADP) [L-aspartate 4-semialdehyde] + [NADPH] ↔ [L-homoserine] + [NADP(+)];   {HOM6} , {L-aspartate 4-semialdehyde} , {NADPH} , {L-homoserine} , {NADP(+)}
 
 homoserine kinase [ATP] + [L-homoserine] ↔ [ADP] + [O-phospho-L-homoserine];   {THR1} , {ATP} , {L-homoserine} , {ADP} , {O-phospho-L-homoserine}
 
 homoserine O-trans-acetylase [acetyl-CoA] + [L-homoserine] ↔ [coenzyme A] + [O-acetyl-L-homoserine];   {MET2} , {acetyl-CoA} , {L-homoserine} , {coenzyme A} , {O-acetyl-L-homoserine}
 
 hydrogen peroxide reductase (thioredoxin) [hydrogen peroxide] + [TRX1] ↔ [TRX1 disulphide];   {TRX1} , {TRX2} , {TSA2} , {DOT5} , {AHP1} , {PRX1} , {TRX3} , {hydrogen peroxide} , {TRX1} , {TRX1 disulphide}
 
 hydroxymethylglutaryl CoA reductase [3-hydroxy-3-methylglutaryl-CoA] + 2.0 × [NADPH] ↔ [(R)-mevalonate] + [coenzyme A] + 2.0 × [NADP(+)];   {HMG2} , {HMG1} , {3-hydroxy-3-methylglutaryl-CoA} , {NADPH} , {(R)-mevalonate} , {coenzyme A} , {NADP(+)}
 
 hydroxymethylglutaryl CoA synthase [acetoacetyl-CoA] + [acetyl-CoA] ↔ [3-hydroxy-3-methylglutaryl-CoA] + [coenzyme A];   {ERG13} , {acetoacetyl-CoA} , {acetyl-CoA} , {3-hydroxy-3-methylglutaryl-CoA} , {coenzyme A}
 
 Imidazole-glycerol-3-phosphate synthase [5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide] + [L-glutamine] ↔ [AICAR] + [D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate] + [L-glutamate];   {HIS7} , {5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide} , {L-glutamine} , {AICAR} , {D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate} , {L-glutamate}
 
 imidazoleglycerol-phosphate dehydratase [D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate] ↔ [3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate];   {HIS3} , {D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate} , {3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate}
 
 IMP dehydrogenase [IMP] + [NAD] ↔ [NADH] + [xanthosine-5-phosphate];   {IMD4} , {IMD2} , {IMD3} , {IMP} , {NAD} , {NADH} , {xanthosine-5-phosphate}
 
 indole-3-glycerol-phosphate synthase [1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate] ↔ [1-C-(indol-3-yl)glycerol 3-phosphate] + [carbon dioxide];   {TRP3} , {1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate} , {1-C-(indol-3-yl)glycerol 3-phosphate} , {carbon dioxide}
 
 inorganic diphosphatase [diphosphate] ↔ 2.0 × [phosphate];   {IPP1} , {PPA2} , {diphosphate} , {phosphate}
 
 inosine monophosphate cyclohydrolase [phosphoribosyl-formamido-carboxamide] ↔ [IMP];   {ADE16} , {ADE17} , {phosphoribosyl-formamido-carboxamide} , {IMP}
 
 IPC synthase [1-phosphatidyl-1D-myo-inositol] + [ceramide-4 (C24)] ↔ [diglyceride] + [inositol-P-ceramide D (C24)];   {AUR1} , {KEI1} , {1-phosphatidyl-1D-myo-inositol} , {ceramide-4 (C24)} , {diglyceride} , {inositol-P-ceramide D (C24)}
 
 isocitrate dehydrogenase (NAD+) [isocitrate] + [NAD] ↔ [2-oxoglutarate] + [carbon dioxide] + [NADH];   {IDH2} , {IDH1} , {isocitrate} , {NAD} , {2-oxoglutarate} , {carbon dioxide} , {NADH}
 
 isocitrate dehydrogenase (NADP+), peroxisomal [isocitrate] + [NADP(+)] ↔ [2-oxoglutarate] + [carbon dioxide] + [NADPH];   {IDP3} , {IDP1} , {isocitrate} , {NADP(+)} , {2-oxoglutarate} , {carbon dioxide} , {NADPH}
 
 isoleucine transaminase [(S)-3-methyl-2-oxopentanoate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-isoleucine];   {BAT2} , {BAT1} , {(S)-3-methyl-2-oxopentanoate} , {L-glutamate} , {2-oxoglutarate} , {L-isoleucine}
 
 isoleucyl-tRNA synthetase [ATP] + [L-isoleucine] + [tRNA(Ile)] ↔ [AMP] + [diphosphate] + [Ile-tRNA(Ile)];   {ILS1} , {ATP} , {L-isoleucine} , {tRNA(Ile)} , {AMP} , {diphosphate} , {Ile-tRNA(Ile)}
 
 isopentenyl-diphosphate D-isomerase [isopentenyl diphosphate] ↔ [prenyl diphosphate];   {IDI1} , {isopentenyl diphosphate} , {prenyl diphosphate}
 
 ketol-acid reductoisomerase (2-aceto-2-hydroxybutanoate) [(S)-2-acetyl-2-hydroxybutanoate] + [NADPH] ↔ [(2R,3R)-2,3-dihydroxy-3-methylpentanoate] + [NADP(+)];   {ILV5} , {(S)-2-acetyl-2-hydroxybutanoate} , {NADPH} , {(2R,3R)-2,3-dihydroxy-3-methylpentanoate} , {NADP(+)}
 
 L-alanine transaminase [L-glutamate] + [pyruvate] ↔ [2-oxoglutarate] + [L-alanine];   {ALT1} , {L-glutamate} , {pyruvate} , {2-oxoglutarate} , {L-alanine}
 
 L-aminoadipate-semialdehyde dehydrogenase (NADPH) [L-2-aminoadipate] + [NADPH] ↔ [L-allysine] + [NADP(+)];   {LYS2} , {LYS5} , {L-2-aminoadipate} , {NADPH} , {L-allysine} , {NADP(+)}
 
 lanosterol synthase [(S)-2,3-epoxysqualene] ↔ [lanosterol];   {ERG7} , {(S)-2,3-epoxysqualene} , {lanosterol}
 
 leucine transaminase [4-methyl-2-oxopentanoate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-leucine];   {BAT2} , {BAT1} , {4-methyl-2-oxopentanoate} , {L-glutamate} , {2-oxoglutarate} , {L-leucine}
 
 leucyl-tRNA synthetase [ATP] + [L-leucine] + [tRNA(Leu)] ↔ [AMP] + [diphosphate] + [Leu-tRNA(Leu)];   {CDC60} , {ATP} , {L-leucine} , {tRNA(Leu)} , {AMP} , {diphosphate} , {Leu-tRNA(Leu)}
 
 lysyl-tRNA synthetase [ATP] + [L-lysine] + [tRNA(Lys)] ↔ [AMP] + [diphosphate] + [Lys-tRNA(Lys)];   {KRS1} , {ATP} , {L-lysine} , {tRNA(Lys)} , {AMP} , {diphosphate} , {Lys-tRNA(Lys)}
 
 malate dehydrogenase [(S)-malate] + [NAD] ↔ [NADH] + [oxaloacetate];   {MDH1} , {MDH2} , {MDH3} , {(S)-malate} , {NAD} , {NADH} , {oxaloacetate}
 
 mannose-1-phosphate guanylyltransferase [D-mannose 1-phosphate] + [GTP] ↔ [diphosphate] + [GDP-alpha-D-mannose];   {PSA1} , {D-mannose 1-phosphate} , {GTP} , {diphosphate} , {GDP-alpha-D-mannose}
 
 mannose-6-phosphate isomerase [D-fructose 6-phosphate] ↔ [D-mannose 6-phosphate];   {PMI40} , {D-fructose 6-phosphate} , {D-mannose 6-phosphate}
 
 methenyltetrahydrifikate cyclohydrolase [5,10-methenyl-THF] ↔ [10-formyl-THF];   {MIS1} , {ADE3} , {5,10-methenyl-THF} , {10-formyl-THF}
 
 methionine adenosyltransferase [ATP] + [L-methionine] ↔ [diphosphate] + [phosphate] + [S-adenosyl-L-methionine];   {SAM2} , {SAM1} , {ATP} , {L-methionine} , {diphosphate} , {phosphate} , {S-adenosyl-L-methionine}
 
 methionine synthase [5-methyltetrahydrofolate] + [L-homocysteine] ↔ [L-methionine] + [THF];   {MET6} , {5-methyltetrahydrofolate} , {L-homocysteine} , {L-methionine} , {THF}
 
 methionyl-tRNA synthetase [ATP] + [L-methionine] + [tRNA(Met)] ↔ [AMP] + [diphosphate] + [Met-tRNA(Met)];   {MES1} , {ATP} , {L-methionine} , {tRNA(Met)} , {AMP} , {diphosphate} , {Met-tRNA(Met)}
 
 methylenetetrahydrofolate dehydrogenase (NAD) [5,10-methylenetetrahydrofolate] + [NAD] ↔ [5,10-methenyl-THF] + [NADH];   {MTD1} , {5,10-methylenetetrahydrofolate} , {NAD} , {5,10-methenyl-THF} , {NADH}
 
 methylenetetrahydrofolate dehydrogenase (NADP) [5,10-methylenetetrahydrofolate] + [NADP(+)] ↔ [5,10-methenyl-THF] + [NADPH];   {ADE3} , {MIS1} , {5,10-methylenetetrahydrofolate} , {NADP(+)} , {5,10-methenyl-THF} , {NADPH}
 
 mevalonate kinase (ctp) [(R)-mevalonate] + [CTP] ↔ [(R)-5-phosphomevalonic acid] + [CDP];   {ERG12} , {(R)-mevalonate} , {CTP} , {(R)-5-phosphomevalonic acid} , {CDP}
 
 mevalonate pyrophoshate decarboxylase [(R)-5-diphosphomevalonic acid] + [ATP] ↔ [ADP] + [carbon dioxide] + [isopentenyl diphosphate] + [phosphate];   {MVD1} , {(R)-5-diphosphomevalonic acid} , {ATP} , {ADP} , {carbon dioxide} , {isopentenyl diphosphate} , {phosphate}
 
 myo-inositol 1-phosphatase [1D-myo-inositol 1-phosphate] ↔ [myo-inositol] + [phosphate];   {INM2} , {INM1} , {1D-myo-inositol 1-phosphate} , {myo-inositol} , {phosphate}
 
 myo-inositol-1-phosphate synthase [D-glucose 6-phosphate] ↔ [1D-myo-inositol 1-phosphate];   {INO1} , {D-glucose 6-phosphate} , {1D-myo-inositol 1-phosphate}
 
 N-acetyl-g-glutamyl-phosphate reductase [N-acetyl-L-gamma-glutamyl phosphate] + [NADPH] ↔ [2-acetamido-5-oxopentanoate] + [NADP(+)] + [phosphate];   {ARG5,6} , {N-acetyl-L-gamma-glutamyl phosphate} , {NADPH} , {2-acetamido-5-oxopentanoate} , {NADP(+)} , {phosphate}
 
 NADH dehydrogenase, cytosolic/mitochondrial [NADH] + [ubiquinone-6] ↔ [NAD] + [ubiquinol-6];   {NDE2} , {NDE1} , {NDI1} , {NADH} , {ubiquinone-6} , {NAD} , {ubiquinol-6}
 
 nucleoside diphosphatase [CDP] ↔ [CMP] + [phosphate];   {YND1} , {CDP} , {CMP} , {phosphate}
 
 nucleoside diphosphate kinase [ATP] + [GDP] ↔ [ADP] + [GTP];   {YNK1} , {ATP} , {GDP} , {ADP} , {GTP}
 
 nucleoside-diphosphate kinase (ATP:UDP) [ATP] + [UDP] ↔ [ADP] + [UTP];   {YNK1} , {ATP} , {UDP} , {ADP} , {UTP}
 
 O-acetylhomoserine (thiol)-lyase [hydrogen sulfide] + [O-acetyl-L-homoserine] ↔ [acetate] + [L-homocysteine];   {MET17} , {hydrogen sulfide} , {O-acetyl-L-homoserine} , {acetate} , {L-homocysteine}
 
 ornithine carbamoyltransferase [carbamoyl phosphate] + [ornithine] ↔ [L-citrulline] + [phosphate];   {ARG3} , {carbamoyl phosphate} , {ornithine} , {L-citrulline} , {phosphate}
 
 ornithine transacetylase [L-glutamate] + [N(2)-acetyl-L-ornithine] ↔ [N-acetyl-L-glutamate] + [ornithine];   {ARG7} , {L-glutamate} , {N(2)-acetyl-L-ornithine} , {N-acetyl-L-glutamate} , {ornithine}
 
 orotate phosphoribosyltransferase [orotate] + [PRPP] ↔ [diphosphate] + [orotidine 5'-(dihydrogen phosphate)];   {URA10} , {URA5} , {orotate} , {PRPP} , {diphosphate} , {orotidine 5'-(dihydrogen phosphate)}
 
 orotidine-5'-phosphate decarboxylase [orotidine 5'-(dihydrogen phosphate)] ↔ [carbon dioxide] + [UMP];   {URA3} , {orotidine 5'-(dihydrogen phosphate)} , {carbon dioxide} , {UMP}
 
 phenylalanine transaminase [keto-phenylpyruvate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-phenylalanine];   {ARO8} , {keto-phenylpyruvate} , {L-glutamate} , {2-oxoglutarate} , {L-phenylalanine}
 
 phenylalanyl-tRNA synthetase [ATP] + [L-phenylalanine] + [tRNA(Phe)] ↔ [AMP] + [diphosphate] + [Phe-tRNA(Phe)];   {FRS1} , {FRS2} , {ATP} , {L-phenylalanine} , {tRNA(Phe)} , {AMP} , {diphosphate} , {Phe-tRNA(Phe)}
 
 phopshoribosylaminoimidazole synthetase [5'-phosphoribosyl-N-formylglycineamidine] + [ATP] ↔ [5'-phosphoribosyl-5-aminoimidazole] + [ADP] + [phosphate];   {ADE5,7} , {5'-phosphoribosyl-N-formylglycineamidine} , {ATP} , {5'-phosphoribosyl-5-aminoimidazole} , {ADP} , {phosphate}
 
 phosphatidylethanolamine methyltransferase [phosphatidylethanolamine] + [S-adenosyl-L-methionine] ↔ [phosphatidyl-N-methylethanolamine] + [S-adenosyl-L-homocysteine];   {OPI3} , {CHO2} , {phosphatidylethanolamine} , {S-adenosyl-L-methionine} , {phosphatidyl-N-methylethanolamine} , {S-adenosyl-L-homocysteine}
 
 phosphatidylinositol synthase [CDP-diacylglycerol] + [myo-inositol] ↔ [1-phosphatidyl-1D-myo-inositol] + [CMP];   {PIS1} , {CDP-diacylglycerol} , {myo-inositol} , {1-phosphatidyl-1D-myo-inositol} , {CMP}
 
 phosphatidylserine decarboxylase [phosphatidyl-L-serine] ↔ [carbon dioxide] + [phosphatidylethanolamine];   {PSD1} , {PSD2} , {phosphatidyl-L-serine} , {carbon dioxide} , {phosphatidylethanolamine}
 
 phosphatidylserine synthase [CDP-diacylglycerol] + [L-serine] ↔ [CMP] + [phosphatidyl-L-serine];   {CHO1} , {CDP-diacylglycerol} , {L-serine} , {CMP} , {phosphatidyl-L-serine}
 
 phosphoadenylyl-sulfate reductase (thioredoxin) [3'-phospho-5'-adenylyl sulfate] + [TRX1] ↔ [adenosine 3',5'-bismonophosphate] + [sulphite] + [TRX1 disulphide];   {TRX1} , {MET16} , {TRX2} , {3'-phospho-5'-adenylyl sulfate} , {TRX1} , {adenosine 3',5'-bismonophosphate} , {sulphite} , {TRX1 disulphide}
 
 phosphofructokinase [ATP] + [D-fructose 6-phosphate] ↔ [ADP] + [D-fructose 1,6-bisphosphate];   {PFK1} , {PFK2} , {ATP} , {D-fructose 6-phosphate} , {ADP} , {D-fructose 1,6-bisphosphate}
 
 phosphoglucomutase [D-glucose 6-phosphate] ↔ [D-glucose 1-phosphate];   {PGM1} , {PGM3} , {PGM2} , {D-glucose 6-phosphate} , {D-glucose 1-phosphate}
 
 phosphoglycerate dehydrogenase [3-phosphoglycerate] + [NAD] ↔ [3-phospho-hydroxypyruvate] + [NADH];   {SER3} , {SER33} , {3-phosphoglycerate} , {NAD} , {3-phospho-hydroxypyruvate} , {NADH}
 
 phosphoglycerate kinase [1,3-bisphospho-D-glycerate] + [ADP] ↔ [3-phosphoglycerate] + [ATP];   {PGK1} , {1,3-bisphospho-D-glycerate} , {ADP} , {3-phosphoglycerate} , {ATP}
 
 phosphoglycerate mutase [3-phosphoglycerate] ↔ [2-phospho-D-glyceric acid];   {GPM1} , {3-phosphoglycerate} , {2-phospho-D-glyceric acid}
 
 phospholipid methyltransferase [phosphatidyl-N,N-dimethylethanolamine] + [S-adenosyl-L-methionine] ↔ [phosphatidylcholine] + [S-adenosyl-L-homocysteine];   {OPI3} , {phosphatidyl-N,N-dimethylethanolamine} , {S-adenosyl-L-methionine} , {phosphatidylcholine} , {S-adenosyl-L-homocysteine}
 
 phospholipid methyltransferase [phosphatidyl-N-methylethanolamine] + [S-adenosyl-L-methionine] ↔ [phosphatidyl-N,N-dimethylethanolamine] + [S-adenosyl-L-homocysteine];   {OPI3} , {phosphatidyl-N-methylethanolamine} , {S-adenosyl-L-methionine} , {phosphatidyl-N,N-dimethylethanolamine} , {S-adenosyl-L-homocysteine}
 
 phosphomannomutase [D-mannose 6-phosphate] ↔ [D-mannose 1-phosphate];   {SEC53} , {D-mannose 6-phosphate} , {D-mannose 1-phosphate}
 
 phosphomevalonate kinase [(R)-5-phosphomevalonic acid] + [ATP] ↔ [(R)-5-diphosphomevalonic acid] + [ADP];   {ERG8} , {(R)-5-phosphomevalonic acid} , {ATP} , {(R)-5-diphosphomevalonic acid} , {ADP}
 
 phosphoribosyl amino imidazolesuccinocarbozamide synthetase [ATP] + [L-aspartate] + [phosphoribosyl-carboxy-aminoimidazole] ↔ [5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole] + [ADP] + [phosphate];   {ADE1} , {ATP} , {L-aspartate} , {phosphoribosyl-carboxy-aminoimidazole} , {5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole} , {ADP} , {phosphate}
 
 phosphoribosyl-AMP cyclohydrolase [1-(5-phosphoribosyl)-5'-AMP] ↔ [1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide];   {HIS4} , {1-(5-phosphoribosyl)-5'-AMP} , {1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide}
 
 phosphoribosyl-ATP pyrophosphatase [5-phosphoribosyl-ATP] ↔ [1-(5-phosphoribosyl)-5'-AMP] + [diphosphate];   {HIS4} , {5-phosphoribosyl-ATP} , {1-(5-phosphoribosyl)-5'-AMP} , {diphosphate}
 
 phosphoribosylaminoimidazole-carboxylase [5'-phosphoribosyl-5-aminoimidazole] + [carbon dioxide] + [ATP] ↔ [phosphoribosyl-carboxy-aminoimidazole] + [ADP] + [phosphate];   {ADE2} , {5'-phosphoribosyl-5-aminoimidazole} , {carbon dioxide} , {ATP} , {phosphoribosyl-carboxy-aminoimidazole} , {ADP} , {phosphate}
 
 phosphoribosylaminoimidazolecarboxamide formyltransferase [10-formyl-THF] + [AICAR] ↔ [phosphoribosyl-formamido-carboxamide] + [THF];   {ADE16} , {ADE17} , {10-formyl-THF} , {AICAR} , {phosphoribosyl-formamido-carboxamide} , {THF}
 
 phosphoribosylanthranilate isomerase [N-(5-phospho-beta-D-ribosyl)anthranilate] ↔ [1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate];   {TRP1} , {N-(5-phospho-beta-D-ribosyl)anthranilate} , {1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate}
 
 phosphoribosylglycinamidine synthetase [5-phosphoribosylamine] + [ATP] + [L-glycine] ↔ [5-phospho-ribosyl-glycineamide] + [ADP] + [phosphate];   {ADE5,7} , {5-phosphoribosylamine} , {ATP} , {L-glycine} , {5-phospho-ribosyl-glycineamide} , {ADP} , {phosphate}
 
 phosphoribosylpyrophosphate amidotransferase [L-glutamine] + [PRPP] ↔ [5-phosphoribosylamine] + [diphosphate] + [L-glutamate];   {ADE4} , {L-glutamine} , {PRPP} , {5-phosphoribosylamine} , {diphosphate} , {L-glutamate}
 
 phosphoribosylpyrophosphate synthetase [ATP] + [ribose-5-phosphate] ↔ [AMP] + [PRPP];   {PRS4} , {PRS2} , {PRS3} , {PRS1} , {PRS5} , {ATP} , {ribose-5-phosphate} , {AMP} , {PRPP}
 
 phosphoserine phosphatase (L-serine) [3-phospho-serine] ↔ [L-serine] + [phosphate];   {SER2} , {3-phospho-serine} , {L-serine} , {phosphate}
 
 phosphoserine transaminase [3-phospho-hydroxypyruvate] + [L-glutamate] ↔ [2-oxoglutarate] + [3-phospho-serine];   {SER1} , {3-phospho-hydroxypyruvate} , {L-glutamate} , {2-oxoglutarate} , {3-phospho-serine}
 
 phytoceramidase [lignoceric acid] + [phytosphingosine] ↔ [ceramide-2 (C24)];   {YPC1} , {lignoceric acid} , {phytosphingosine} , {ceramide-2 (C24)}
 
 phytosphingosine synthesis [NADPH] + [oxygen] + [sphinganine] ↔ [NADP(+)] + [phytosphingosine];   {SUR2} , {NADPH} , {oxygen} , {sphinganine} , {NADP(+)} , {phytosphingosine}
 
 prephenate dehydratase [prephenate] ↔ [carbon dioxide] + [keto-phenylpyruvate];   {PHA2} , {prephenate} , {carbon dioxide} , {keto-phenylpyruvate}
 
 prephenate dehydrogenase (NADP) [NADP(+)] + [prephenate] ↔ [3-(4-hydroxyphenyl)pyruvate] + [carbon dioxide] + [NADPH];   {TYR1} , {NADP(+)} , {prephenate} , {3-(4-hydroxyphenyl)pyruvate} , {carbon dioxide} , {NADPH}
 
 prolyl-tRNA synthetase [ATP] + [L-proline] + [tRNA(Pro)] ↔ [AMP] + [diphosphate] + [Pro-tRNA(Pro)];   {AIM10} , {ATP} , {L-proline} , {tRNA(Pro)} , {AMP} , {diphosphate} , {Pro-tRNA(Pro)}
 
 pyrroline-5-carboxylate reductase [1-pyrroline-5-carboxylate] + [NADPH] ↔ [L-proline] + [NADP(+)];   {PRO3} , {1-pyrroline-5-carboxylate} , {NADPH} , {L-proline} , {NADP(+)}
 
 pyruvate carboxylase [ATP] + [bicarbonate] + [pyruvate] ↔ [