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BIOMD0000000471 - Smallbone2013 - Yeast metabolic model with linlog rate law

 

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Reference Publication
Publication ID: 10.1089/ind.2013.000...
Messiha HL, Kent E, Malys N, Carroll KM, Mendes P, Smallbone K.
Large-Scale Metabolic Models: From Reconstruction to Differential Equations
Industrial Biotechnology
Manchester Centre for Integrative Systems Biology and School of Computer Science, University of Manchester, Manchester Institute of Biotechnology, Manchester, UK  [more]
Model
Original Model: BIOMD0000000471.origin
Submitter: Kieran Smallbone
Submission ID: MODEL1302140003
Submission Date: 14 Feb 2013 10:57:43 UTC
Last Modification Date: 29 Apr 2014 11:42:00 UTC
Creation Date: 20 Feb 2008 10:05:10 UTC
Encoders:  Nick Juty
   Vijayalakshmi Chelliah
   Kieran Smallbone
set #1
bqbiol:isVersionOf Gene Ontology metabolic process
set #2
bqbiol:hasTaxon Taxonomy Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Notes
Model
Publication ID: 10.1089/ind.2013.000... Submission Date: 14 Feb 2013 10:57:43 UTC Last Modification Date: 29 Apr 2014 11:42:00 UTC Creation Date: 20 Feb 2008 10:05:10 UTC
Mathematical expressions
Reactions
1,3-beta-glucan synthase 1,6-beta-glucan synthase 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase 1-acyl-sn-gylcerol-3-phosphate acyltransferase
1-pyrroline-5-carboxylate dehydrogenase 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (NADPH) 2-aceto-2-hydroxybutanoate synthase
2-aminoadipate transaminase 2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase 2-isopropylmalate hydratase 2-isopropylmalate synthase
2-methylcitrate dehydratase 2-oxo-4-methyl-3-carboxypentanoate decarboxylation 3',5'-bisphosphate nucleotidase 3,4-dihydroxy-2-butanone-4-phosphate synthase
3-dehydroquinate dehydratase 3-dehydroquinate synthase 3-dehydrosphinganine reductase 3-isopropylmalate dehydratase
3-isopropylmalate dehydrogenase 3-phosphoshikimate 1-carboxyvinyltransferase 5'-phosphoribosylformyl glycinamidine synthetase 5,10-methylenetetrahydrofolate reductase (NADPH)
acetohydroxy acid isomeroreductase acetolactate synthase acetyl-CoA C-acetyltransferase acetyl-Coa carboxylase
acetyl-CoA hydrolase acetylglutamate kinase acteylornithine transaminase adenosine kinase
adenosylhomocysteinase adenylate kinase adenylosuccinate lyase (AICAR) adenylosuccinate lyase
adenylosuccinate synthase adenylyl-sulfate kinase alanyl-tRNA synthetase alpha,alpha-trehalose-phosphate synthase (UDP-forming)
anthranilate phosphoribosyltransferase anthranilate synthase argininosuccinate lyase argininosuccinate synthase
arginyl-tRNA synthetase asparagine synthase (glutamine-hydrolysing) Asparaginyl-tRNA synthetase aspartate carbamoyltransferase
aspartate kinase aspartate transaminase aspartate-semialdehyde dehydrogenase Aspartyl-tRNA synthetase
ATP phosphoribosyltransferase C-14 sterol reductase C-22 sterol desaturase (NADP) C-3 sterol dehydrogenase
C-3 sterol dehydrogenase (4-methylzymosterol) C-3 sterol keto reductase (4-methylzymosterol) C-3 sterol keto reductase (zymosterol) C-4 methyl sterol oxidase
C-4 methyl sterol oxidase C-4 methyl sterol oxidase C-4 sterol methyl oxidase (4,4-dimethylzymosterol) C-5 sterol desaturase
C-8 sterol isomerase C-s24 sterol reductase carbamoyl-phosphate synthase (glutamine-hydrolysing) CDP-diacylglycerol synthase
ceramide-1 hydroxylase (24C) ceramide-3 synthase (24C) ceramide-4 synthase (24C) chorismate mutase
chorismate synthase cis-aconitate(3-) to isocitrate citrate synthase citrate to cis-aconitate(3-)
CTP synthase (NH3) cystathionine beta-synthase cystathionine g-lyase cystathionine gamma-synthase
cysteinyl-tRNA synthetase cytochrome P450 lanosterol 14-alpha-demethylase (NADP) dCMP deaminase deoxyguanylate kinase (dGMP:ATP)
diacylglycerol acyltransferase diacylglycerol pyrophosphate phosphatase dihydoorotic acid dehydrogenase dihydroceramidase
dihydrofolate reductase dihydroorotase dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)
dimethylallyltranstransferase dolichyl-phosphate D-mannosyltransferase dolichyl-phosphate-mannose--protein mannosyltransferase dUTP diphosphatase
enolase fatty acid synthase (n-C12:0) fatty acid synthase (n-C14:0) fatty acid synthase (n-C16:0)
fatty acid synthase (n-C18:0) fatty acid synthase (n-C24:0), lumped reaction fatty acyl-CoA synthase (n-C10:0CoA) fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
fatty-acid--CoA ligase (decanoate) fatty-acid--CoA ligase (dodecanoate) fatty-acid--CoA ligase (octadecanoate) fatty-acyl-CoA synthase (n-C12:0CoA)
fatty-acyl-CoA synthase (n-C14:0CoA) fatty-acyl-CoA synthase (n-C16:0CoA) fatty-acyl-CoA synthase (n-C18:0CoA) ferrocytochrome-c:oxygen oxidoreductase
ferrocytochrome-c:oxygen oxidoreductase formate-tetrahydrofolate ligase fructose-bisphosphate aldolase fumarase
geranyltranstransferase glucose-6-phosphate isomerase glutamate dehydrogenase (NAD) glutamate dehydrogenase (NADP)
glutamine synthetase glutaminyl-tRNA synthetase glutamyl-tRNA synthetase glutathione oxidoreductase
glutathione peridoxase glyceraldehyde-3-phosphate dehydrogenase glycerol-3-phosphate dehydrogenase (NAD) glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase
glycinamide ribotide transformylase glycine cleavage system glycine hydroxymethyltransferase glycogen (starch) synthase
glycyl-tRNA synthetase GMP synthase GTP cyclohydrolase II guanylate kinase
guanylate kinase (GMP:dATP) hexokinase (D-glucose:ATP) histidinol dehydrogenase histidinol-phosphatase
histidinol-phosphate transaminase histidyl-tRNA synthetase homoacontinate hydratase homocitrate synthase
homoisocitrate dehydrogenase homoserine dehydrogenase (NADP) homoserine kinase homoserine O-trans-acetylase
hydrogen peroxide reductase (thioredoxin) hydroxymethylglutaryl CoA reductase hydroxymethylglutaryl CoA synthase Imidazole-glycerol-3-phosphate synthase
imidazoleglycerol-phosphate dehydratase IMP dehydrogenase indole-3-glycerol-phosphate synthase inorganic diphosphatase
inosine monophosphate cyclohydrolase IPC synthase isocitrate dehydrogenase (NAD+) isocitrate dehydrogenase (NADP+), peroxisomal
isoleucine transaminase isoleucyl-tRNA synthetase isopentenyl-diphosphate D-isomerase ketol-acid reductoisomerase (2-aceto-2-hydroxybutanoate)
L-alanine transaminase L-aminoadipate-semialdehyde dehydrogenase (NADPH) lanosterol synthase leucine transaminase
leucyl-tRNA synthetase lysyl-tRNA synthetase malate dehydrogenase mannose-1-phosphate guanylyltransferase
mannose-6-phosphate isomerase methenyltetrahydrifikate cyclohydrolase methionine adenosyltransferase methionine synthase
methionyl-tRNA synthetase methylenetetrahydrofolate dehydrogenase (NAD) methylenetetrahydrofolate dehydrogenase (NADP) mevalonate kinase (ctp)
mevalonate pyrophoshate decarboxylase myo-inositol 1-phosphatase myo-inositol-1-phosphate synthase N-acetyl-g-glutamyl-phosphate reductase
NADH dehydrogenase, cytosolic/mitochondrial nucleoside diphosphatase nucleoside diphosphate kinase nucleoside-diphosphate kinase (ATP:UDP)
O-acetylhomoserine (thiol)-lyase ornithine carbamoyltransferase ornithine transacetylase orotate phosphoribosyltransferase
orotidine-5'-phosphate decarboxylase phenylalanine transaminase phenylalanyl-tRNA synthetase phopshoribosylaminoimidazole synthetase
phosphatidylethanolamine methyltransferase phosphatidylinositol synthase phosphatidylserine decarboxylase phosphatidylserine synthase
phosphoadenylyl-sulfate reductase (thioredoxin) phosphofructokinase phosphoglucomutase phosphoglycerate dehydrogenase
phosphoglycerate kinase phosphoglycerate mutase phospholipid methyltransferase phospholipid methyltransferase
phosphomannomutase phosphomevalonate kinase phosphoribosyl amino imidazolesuccinocarbozamide synthetase phosphoribosyl-AMP cyclohydrolase
phosphoribosyl-ATP pyrophosphatase phosphoribosylaminoimidazole-carboxylase phosphoribosylaminoimidazolecarboxamide formyltransferase phosphoribosylanthranilate isomerase
phosphoribosylglycinamidine synthetase phosphoribosylpyrophosphate amidotransferase phosphoribosylpyrophosphate synthetase phosphoserine phosphatase (L-serine)
phosphoserine transaminase phytoceramidase phytosphingosine synthesis prephenate dehydratase
prephenate dehydrogenase (NADP) prolyl-tRNA synthetase pyrroline-5-carboxylate reductase pyruvate carboxylase
pyruvate dehydrogenase pyruvate kinase riboflavin synthase riboflavin synthase
ribonucleoside-triphosphate reductase (ATP) ribonucleoside-triphosphate reductase (UTP) ribonucleotide reductase ribonucleotide reductase
ribonucleotide reductase ribose-5-phosphate isomerase ribulose 5-phosphate 3-epimerase S-adenosyl-methionine delta-24-sterol-c-methyltransferase
saccharopine dehydrogenase (NAD, L-lysine forming) saccharopine dehydrogenase (NADP, L-glutamate forming) serine palmitotransferase seryl-tRNA synthetase
shikimate dehydrogenase shikimate kinase squalene epoxidase (NAD) squalene epoxidase (NADP)
squalene synthase steryl ester hydrolase sulfate adenylyltransferase (ADP) sulfite reductase (NADPH2)
thioredoxin reductase (NADPH) threonine synthase threonyl-tRNA synthetase thymidylate synthase
transaldolase transketolase 1 transketolase 2 trehalose-phosphatase
triacylglycerol lipase triose-phosphate isomerase tryptophan synthase (indoleglycerol phosphate) tryptophanyl-tRNA synthetase
tyrosine transaminase tyrosyl-tRNA synthetase UMP kinase UTP-glucose-1-phosphate uridylyltransferase
valine transaminase valyl-tRNA synthetase ammonia transport glucose transport
phosphate transport sulfate uniport bicarbonate formation CO2 transport
cytidylate kinase (dCMP) deoxyadenylate kinase formate transport O2 transport
pyrimidine phosphatase growth    
Physical entities
Compartments Species
cell (1->3)-beta-D-glucan (1->6)-beta-D-glucan (2R,3R)-2,3-dihydroxy-3-methylpentanoate
(2R,3S)-3-isopropylmalate (2S)-2-isopropyl-3-oxosuccinate (N(omega)-L-arginino)succinic acid
(R)-2,3-dihydroxy-3-methylbutanoate (R)-5-diphosphomevalonic acid (R)-5-phosphomevalonic acid
(R)-mevalonate (S)-2,3-epoxysqualene (S)-2-acetyl-2-hydroxybutanoate
(S)-3-methyl-2-oxopentanoate (S)-dihydroorotate (S)-malate
1,3-bisphospho-D-glycerate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
1-(5-phosphoribosyl)-5'-AMP 1-acyl-sn-glycerol 3-phosphate 1-C-(indol-3-yl)glycerol 3-phosphate
1-phosphatidyl-1D-myo-inositol 1-pyrroline-5-carboxylate 10-formyl-THF
14-demethyllanosterol 1D-myo-inositol 1-phosphate 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine
2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone 2-acetamido-5-oxopentanoate 2-acetyllactic acid
2-hydroxy-3-oxobutyl phosphate 2-isopropylmalate 2-isopropylmaleic acid
2-oxoadipic acid 2-oxobutanoate 2-oxoglutarate
2-phospho-D-glyceric acid farnesyl diphosphate 3'-phospho-5'-adenylyl sulfate
3-(4-hydroxyphenyl)pyruvate 3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate 3-dehydro-4-methylzymosterol
3-dehydroquinate 3-dehydroshikimate 3-hydroxy-3-methylglutaryl-CoA
3-ketosphinganine 3-methyl-2-oxobutanoate 3-phospho-hydroxypyruvate
3-phospho-serine 3-phosphoglycerate 3-phosphoshikimic acid
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol 4-methyl-2-oxopentanoate 4-phospho-L-aspartate
4alpha-methylzymosterol 4beta-methylzymosterol-4alpha-carboxylic acid 5'-adenylyl sulfate
5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole 5'-phosphoribosyl-5-aminoimidazole 5'-phosphoribosyl-N-formylglycineamide
5'-phosphoribosyl-N-formylglycineamidine 5,10-methenyl-THF 5,10-methylenetetrahydrofolate
5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 5-amino-6-(5-phosphoribitylamino)uracil 5-amino-6-(D-ribitylamino)uracil
5-methyltetrahydrofolate 5-O-(1-carboxyvinyl)-3-phosphoshikimic acid 5-phospho-ribosyl-glycineamide
5-phosphoribosyl-ATP 5-phosphoribosylamine 6,7-dimethyl-8-(1-D-ribityl)lumazine
7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid acetate acetoacetyl-CoA
acetyl-CoA acyl-CoA adenosine
adenosine 3',5'-bismonophosphate adenylo-succinate ADP
AICAR Ala-tRNA(Ala) alpha,alpha-trehalose 6-phosphate
ammonium AMP anthranilate
Arg-tRNA(Arg) Asn-tRNA(Asn) Asp-tRNA(Asp)
ATP bicarbonate but-1-ene-1,2,4-tricarboxylic acid
carbamoyl phosphate carbon dioxide CDP
CDP-diacylglycerol ceramide-1 (C24) ceramide-2 (C24)
ceramide-3 (C24) ceramide-4 (C24) chorismate
cis-aconitate citrate CMP
coenzyme A CTP Cys-tRNA(Cys)
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate D-erythrose 4-phosphate D-fructose 1,6-bisphosphate
D-fructose 6-phosphate D-glucose D-glucose 1-phosphate
D-glucose 6-phosphate D-mannose 1-phosphate D-mannose 6-phosphate
D-ribulose 5-phosphate D-xylulose 5-phosphate dADP
dAMP dATP dCDP
dCMP decanoate decanoyl-CoA
dGDP dGMP diglyceride
dihydrofolic acid dihydroxyacetone phosphate diphosphate
dolichyl D-mannosyl phosphate dolichyl phosphate dTMP
dUMP dUTP episterol
ergosta-5,7,22,24(28)-tetraen-3beta-ol ergosta-5,7,24(28)-trien-3beta-ol ergosterol
ergosterol ester fecosterol ferricytochrome c
ferrocytochrome c formate fumarate
GDP GDP-alpha-D-mannose geranyl diphosphate
Gln-tRNA(Gln) Glu-tRNA(Glu) glutathione
glutathione disulfide Gly-tRNA(Gly) glyceraldehyde 3-phosphate
glycerol 3-phosphate glycogen GMP
GTP His-tRNA(His) homocitrate
homoisocitrate hydrogen peroxide hydrogen sulfide
Ile-tRNA(Ile) IMP inositol-P-ceramide D (C24)
isocitrate isopentenyl diphosphate keto-phenylpyruvate
L-2-aminoadipate L-alanine L-allysine
L-arginine L-asparagine L-aspartate
L-aspartate 4-semialdehyde L-citrulline L-cystathionine
L-cysteine L-glutamate L-glutamine
L-glycine L-histidine L-histidinol
L-histidinol phosphate L-homocysteine L-homoserine
L-isoleucine L-leucine L-lysine
L-methionine L-phenylalanine L-proline
L-saccharopine L-serine L-threonine
L-tryptophan L-tyrosine L-valine
lanosterol laurate lauroyl-CoA
Leu-tRNA(Leu) lignoceric acid Lys-tRNA(Lys)
malonyl-CoA mannan Met-tRNA(Met)
myo-inositol myristate myristoyl-CoA
N(2)-acetyl-L-ornithine N-(5-phospho-beta-D-ribosyl)anthranilate N-acetyl-L-gamma-glutamyl phosphate
N-acetyl-L-glutamate N-carbamoyl-L-aspartate NAD
NADH NADP(+) NADPH
O-acetyl-L-homoserine O-phospho-L-homoserine octanoyl-CoA
ornithine orotate orotidine 5'-(dihydrogen phosphate)
oxaloacetate oxygen palmitate
palmitoyl-CoA Phe-tRNA(Phe) phosphate
phosphatidate phosphatidyl-L-serine phosphatidyl-N,N-dimethylethanolamine
phosphatidyl-N-methylethanolamine phosphatidylcholine phosphatidylethanolamine
phosphoenolpyruvate phosphoribosyl-carboxy-aminoimidazole phosphoribosyl-formamido-carboxamide
phytosphingosine prenyl diphosphate prephenate
Pro-tRNA(Pro) PRPP pyruvate
riboflavin ribose-5-phosphate S-adenosyl-L-homocysteine
S-adenosyl-L-methionine sedoheptulose 7-phosphate Ser-tRNA(Ser)
shikimate sphinganine squalene
stearate stearoyl-CoA sulphate
sulphite THF Thr-tRNA(Thr)
trehalose triglyceride Trp-tRNA(Trp)
Tyr-tRNA(Tyr) ubiquinol-6 ubiquinone-6
UDP UDP-D-glucose UMP
UTP Val-tRNA(Val) xanthosine-5-phosphate
zymosterol zymosterol intermediate 1a zymosterol intermediate 1b
zymosterol intermediate 1c zymosterol intermediate 2 tRNA(Ala)
tRNA(Arg) tRNA(Asn) tRNA(Asp)
tRNA(Cys) tRNA(Gln) tRNA(Glu)
tRNA(Gly) tRNA(His) tRNA(Ile)
tRNA(Leu) tRNA(Lys) tRNA(Met)
tRNA(Phe) tRNA(Pro) tRNA(Ser)
tRNA(Thr) tRNA(Trp) tRNA(Tyr)
tRNA(Val) TRX1 TRX1 disulphide
COX1 COB COX2
COX3 CYS3 PMT2
CDC19 GCV3 GDH3
ADE1 SCT1 ACH1
RIB1 URA7 COR1
PRX1 PRS4 ILS1
IPP1 CDS1 TSC3
MIS1 LYS2 TKL2
GRS1 TPS1 RIB7
TYR1 YPC1 PGI1
PYC2 PDB1 GPX2
HIS7 ARO4 DUT1
RIB5 SHM1 TSC10
ILV6 LEU2 HIS4
GRX1 GLK1 APA1
CIT2 PGK1 FEN1
THR4 TRX3 TSC13
GPD1 SLC1 PSA1
IDP1 COX9 MDH3
NDE2 PMT5 PMT1
LYS21 LYS20 GDH2
TRP1 GCV1 SES1
ARO3 KRS1 TPI1
TGL2 LCB2 TPS2
GRX3 ARO1 HOM2
ADK1 LYS4 DPP1
INM2 SUR2 YDR341C
TRR1 TRP4 KEI1
ADE8 TSA2 GUK1
RIB3 SAM2 GRX2
QCR7 URA3 RIP1
CYC7 PMI40 YND1
FAA2 PRO3 CHO1
SAH1 HOM3 HIS1
ARG5,6 RNR1 SER3
AIM10 TRP2 MET6
PRS2 ADK2 GRX4
PDA1 LPD1 FRS2
SEC53 GSY1 HIS2
MET10 QCR6 HXK1
ERG26 LEU1 ERG4
TRP5 PYC1 MET13
ARO2 LYS5 COX4
COX13 ARO8 ADE5,7
GUS1 HXK2 GSC2
ACB1 ERG25 ADE6
VAS1 ASN2 SKN1
CYS4 CHO2 PSD2
ERG1 RNR4 QCR9
TYS1 TDH3 PDX1
ADE3 SER2 TRX2
PFK1 ENO1 MES1
PRS3 QCR10 ERG11
DIA4 ARG4 DED81
THR1 PUT2 NCP1
INM1 COX6 ERG7
TRR2 DCD1 ENO2
ERG9 BAT1 IMD2
FAA3 DOT5 HIS6
RNR3 SER33 THS1
LYS12 COX5B HIS5
LYS1 HYR1 RNR2
TDH1 BNA3 ARG3
RPE1 URA2 GLG2
INO1 QCR8 ERG20
TDH2 ILV3 CYC1
OPI3 URA8 ADO1
CPA2 STR2 MET5
HOM6 PMT4 BAT2
MET14 AUR1 URA6
GPX1 UGP1 FBA1
YNK1 MDH1 AAT1
PGM1 TGL1 GPM1
PRS1 FAS1 TRP3
URA1 GLG1 GPT2
MTD1 TGL4 YEH1
DPS1 AAT2 ADE16
COX12 TRX1 ERG3
SHM2 FRS1 ALT1
ERG27 AHP1 SAM1
GSY2 MET17 ACO1
FKS1 TAL1 ILV5
ADE13 SUR4 COX8
URA4 IMD3 HMG2
ERG6 IMD4 HMG1
TSL1 URA5 NDI1
ERG13 ERG5 ARG7
PGM2 ILV2 ADE17
NDE1 GCV2 ERG2
PFK2 HFA1 ERG12
GUA1 ERG8 FAA4
COX7 TPS3 PPA2
URA10 SCS7 PGM3
LCB1 ADE4 TGL3
IDP3 IDH1 COX5A
LAT1 LEU4 PSD1
ADE12 YNL247W MET2
ERG24 PHA2 CIT1
ACC1 MVD1 LYS9
ARG1 GPD2 PRS5
MET22 RIB2 WRS1
MDH2 ARG8 RIB4
CYT1 CDC21 TGL5
RKI1 LEU9 ADE2
IDH2 GLN4 ALE1
SER1 HIS3 DFR1
DGA1 CPA1 FAA1
PMT3 ALA1 PYK2
GDH1 MET12 ERG10
GRX5 YDC1 GLR1
IDI1 CDC60 FAS2
FUM1 CIT3 HTS1
GLN1 ARO7 TKL1
GRS2 PIS1 ASN1
KRE6 MET16 DPM1
QCR2 YER152C  
extracellular ammonium carbon dioxide D-glucose
formate oxygen phosphate
sulphate    
Global parameters
zero_flux ic0002 ic0004 ic0008
ic0009 ic0010 ic0015 ic0016
ic0018 ic0019 ic0028 ic0037
ic0039 ic0056 ic0061 ic0066
ic0075 ic0076 ic0077 ic0078
ic0082 ic0086 ic0089 ic0118
ic0120 ic0122 ic0126 ic0141
ic0142 ic0145 ic0146 ic0158
ic0162 ic0165 ic0176 ic0178
ic0180 ic0188 ic0190 ic0201
ic0204 ic0207 ic0209 ic0210
ic0211 ic0218 ic0231 ic0232
ic0258 ic0259 ic0260 ic0261
ic0262 ic0291 ic0295 ic0296
ic0297 ic0298 ic0299 ic0300
ic0301 ic0302 ic0304 ic0306
ic0312 ic0313 ic0314 ic0322
ic0324 ic0325 ic0326 ic0327
ic0328 ic0349 ic0362 ic0367
ic0373 ic0380 ic0386 ic0390
ic0393 ic0394 ic0403 ic0404
ic0409 ic0419 ic0420 ic0423
ic0427 ic0428 ic0430 ic0432
ic0434 ic0445 ic0454 ic0455
ic0456 ic0467 ic0471 ic0475
ic0481 ic0493 ic0499 ic0515
ic0516 ic0522 ic0526 ic0529
ic0539 ic0542 ic0550 ic0551
ic0555 ic0557 ic0563 ic0565
ic0567 ic0568 ic0573 ic0574
ic0577 ic0581 ic0582 ic0584
ic0586 ic0587 ic0589 ic0595
ic0602 ic0613 ic0615 ic0619
ic0625 ic0629 ic0633 ic0644
ic0645 ic0649 ic0654 ic0656
ic0657 ic0662 ic0664 ic0666
ic0672 ic0700 ic0709 ic0710
ic0722 ic0725 ic0739 ic0743
ic0745 ic0747 ic0748 ic0750
ic0754 ic0757 ic0764 ic0767
ic0773 ic0782 ic0785 ic0832
ic0835 ic0836 ic0837 ic0841
ic0847 ic0849 ic0918 ic0940
ic0943 ic0951 ic0953 ic0955
ic0959 ic0965 ic0969 ic0973
ic0978 ic0979 ic0980 ic0981
ic0991 ic0999 ic1003 ic1006
ic1010 ic1011 ic1012 ic1014
ic1016 ic1021 ic1025 ic1029
ic1032 ic1035 ic1038 ic1039
ic1045 ic1048 ic1051 ic1056
ic1059 ic1065 ic1073 ic1077
ic1084 ic1099 ic1101 ic1107
ic1148 ic1153 ic1161 ic1176
ic1182 ic1187 ic1191 ic1192
ic1194 ic1198 ic1203 ic1207
ic1212 ic1233 ic1238 ic1255
ic1266 ic1269 ic1270 ic1271
ic1275 ic1277 ic1286 ic1302
ic1314 ic1322 ic1324 ic1331
ic1337 ic1342 ic1343 ic1346
ic1351 ic1360 ic1364 ic1365
ic1366 ic1376 ic1377 ic1379
ic1386 ic1399 ic1405 ic1408
ic1413 ic1416 ic1427 ic1428
ic1429 ic1445 ic1447 ic1449
ic1454 ic1467 ic1468 ic1469
ic1487 ic1491 ic1520 ic1524
ic1527 ic1533 ic1535 ic1537
ic1538 ic1543 ic1545 ic1559
ic1561 ic1565 ic1569 ic1576
ic1577 ic1578 ic1579 ic1582
ic1583 ic1585 ic1587 ic1589
ic1590 ic1591 ic1593 ic1594
ic1596 ic1598 ic1600 ic1602
ic1604 ic1606 ic1607 ic1608
ic1610 ic1612 ic1614 ic1616
ic1620      
Reactions (282)
 
 1,3-beta-glucan synthase [UDP-D-glucose] ↔ [(1->3)-beta-D-glucan] + [UDP];   {FKS1} , {GSC2} , {UDP-D-glucose} , {(1->3)-beta-D-glucan} , {UDP}
 
 1,6-beta-glucan synthase [UDP-D-glucose] ↔ [(1->6)-beta-D-glucan] + [UDP];   {KRE6} , {SKN1} , {UDP-D-glucose} , {(1->6)-beta-D-glucan} , {UDP}
 
 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase [1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide] ↔ [5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide];   {HIS6} , {1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide} , {5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide}
 
 1-acyl-sn-gylcerol-3-phosphate acyltransferase [1-acyl-sn-glycerol 3-phosphate] + [acyl-CoA] ↔ [coenzyme A] + [phosphatidate];   {ALE1} , {SLC1} , {FEN1} , {1-acyl-sn-glycerol 3-phosphate} , {acyl-CoA} , {coenzyme A} , {phosphatidate}
 
 1-pyrroline-5-carboxylate dehydrogenase [L-glutamate] + [NADH] ↔ [1-pyrroline-5-carboxylate] + [NAD];   {PUT2} , {L-glutamate} , {NADH} , {1-pyrroline-5-carboxylate} , {NAD}
 
 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase [2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone] ↔ [5-amino-6-(5-phosphoribitylamino)uracil] + [ammonium];   {RIB2} , {2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone} , {5-amino-6-(5-phosphoribitylamino)uracil} , {ammonium}
 
 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (NADPH) [2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine] + [NADPH] ↔ [2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone] + [NADP(+)];   {RIB7} , {2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine} , {NADPH} , {2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone} , {NADP(+)}
 
 2-aceto-2-hydroxybutanoate synthase [2-oxobutanoate] + [pyruvate] ↔ [(S)-2-acetyl-2-hydroxybutanoate] + [carbon dioxide];   {ILV2} , {ILV6} , {2-oxobutanoate} , {pyruvate} , {(S)-2-acetyl-2-hydroxybutanoate} , {carbon dioxide}
 
 2-aminoadipate transaminase [2-oxoadipic acid] + [L-glutamate] ↔ [2-oxoglutarate] + [L-2-aminoadipate];   {ARO8} , {BNA3} , {YER152C} , {2-oxoadipic acid} , {L-glutamate} , {2-oxoglutarate} , {L-2-aminoadipate}
 
 2-deoxy-D-arabino-heptulosonate 7-phosphate synthetase [D-erythrose 4-phosphate] + [phosphoenolpyruvate] ↔ [7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid] + [phosphate];   {ARO3} , {ARO4} , {D-erythrose 4-phosphate} , {phosphoenolpyruvate} , {7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid} , {phosphate}
 
 2-isopropylmalate hydratase [2-isopropylmalate] ↔ [2-isopropylmaleic acid];   {LEU1} , {2-isopropylmalate} , {2-isopropylmaleic acid}
 
 2-isopropylmalate synthase [3-methyl-2-oxobutanoate] + [acetyl-CoA] ↔ [2-isopropylmalate] + [coenzyme A];   {LEU4} , {LEU9} , {3-methyl-2-oxobutanoate} , {acetyl-CoA} , {2-isopropylmalate} , {coenzyme A}
 
 2-methylcitrate dehydratase [homocitrate] ↔ [but-1-ene-1,2,4-tricarboxylic acid];   {LYS4} , {homocitrate} , {but-1-ene-1,2,4-tricarboxylic acid}
 
 2-oxo-4-methyl-3-carboxypentanoate decarboxylation [(2S)-2-isopropyl-3-oxosuccinate] ↔ [4-methyl-2-oxopentanoate] + [carbon dioxide];   {BAT2} , {BAT1} , {(2S)-2-isopropyl-3-oxosuccinate} , {4-methyl-2-oxopentanoate} , {carbon dioxide}
 
 3',5'-bisphosphate nucleotidase [adenosine 3',5'-bismonophosphate] ↔ [AMP] + [phosphate];   {MET22} , {adenosine 3',5'-bismonophosphate} , {AMP} , {phosphate}
 
 3,4-dihydroxy-2-butanone-4-phosphate synthase [D-ribulose 5-phosphate] ↔ [2-hydroxy-3-oxobutyl phosphate] + [formate];   {RIB3} , {D-ribulose 5-phosphate} , {2-hydroxy-3-oxobutyl phosphate} , {formate}
 
 3-dehydroquinate dehydratase [3-dehydroquinate] ↔ [3-dehydroshikimate];   {ARO1} , {3-dehydroquinate} , {3-dehydroshikimate}
 
 3-dehydroquinate synthase [7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid] ↔ [3-dehydroquinate] + [phosphate];   {ARO1} , {7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid} , {3-dehydroquinate} , {phosphate}
 
 3-dehydrosphinganine reductase [3-ketosphinganine] + [NADPH] ↔ [NADP(+)] + [sphinganine];   {TSC10} , {3-ketosphinganine} , {NADPH} , {NADP(+)} , {sphinganine}
 
 3-isopropylmalate dehydratase [2-isopropylmaleic acid] ↔ [(2R,3S)-3-isopropylmalate];   {LEU1} , {2-isopropylmaleic acid} , {(2R,3S)-3-isopropylmalate}
 
 3-isopropylmalate dehydrogenase [(2R,3S)-3-isopropylmalate] + [NAD] ↔ [(2S)-2-isopropyl-3-oxosuccinate] + [NADH];   {LEU2} , {(2R,3S)-3-isopropylmalate} , {NAD} , {(2S)-2-isopropyl-3-oxosuccinate} , {NADH}
 
 3-phosphoshikimate 1-carboxyvinyltransferase [3-phosphoshikimic acid] + [phosphoenolpyruvate] ↔ [5-O-(1-carboxyvinyl)-3-phosphoshikimic acid] + [phosphate];   {ARO1} , {3-phosphoshikimic acid} , {phosphoenolpyruvate} , {5-O-(1-carboxyvinyl)-3-phosphoshikimic acid} , {phosphate}
 
 5'-phosphoribosylformyl glycinamidine synthetase [5'-phosphoribosyl-N-formylglycineamide] + [ATP] + [L-glutamine] ↔ [5'-phosphoribosyl-N-formylglycineamidine] + [ADP] + [L-glutamate] + [phosphate];   {ADE6} , {5'-phosphoribosyl-N-formylglycineamide} , {ATP} , {L-glutamine} , {5'-phosphoribosyl-N-formylglycineamidine} , {ADP} , {L-glutamate} , {phosphate}
 
 5,10-methylenetetrahydrofolate reductase (NADPH) [5,10-methylenetetrahydrofolate] + [NADPH] ↔ [5-methyltetrahydrofolate] + [NADP(+)];   {MET13} , {MET12} , {5,10-methylenetetrahydrofolate} , {NADPH} , {5-methyltetrahydrofolate} , {NADP(+)}
 
 acetohydroxy acid isomeroreductase [2-acetyllactic acid] + [NADPH] ↔ [(R)-2,3-dihydroxy-3-methylbutanoate] + [NADP(+)];   {ILV5} , {2-acetyllactic acid} , {NADPH} , {(R)-2,3-dihydroxy-3-methylbutanoate} , {NADP(+)}
 
 acetolactate synthase 2.0 × [pyruvate] ↔ [2-acetyllactic acid] + [carbon dioxide];   {ILV2} , {ILV6} , {pyruvate} , {2-acetyllactic acid} , {carbon dioxide}
 
 acetyl-CoA C-acetyltransferase 2.0 × [acetyl-CoA] ↔ [acetoacetyl-CoA] + [coenzyme A];   {ERG10} , {acetyl-CoA} , {acetoacetyl-CoA} , {coenzyme A}
 
 acetyl-Coa carboxylase [acetyl-CoA] + [ATP] + [bicarbonate] ↔ [ADP] + [malonyl-CoA] + [phosphate];   {HFA1} , {ACC1} , {acetyl-CoA} , {ATP} , {bicarbonate} , {ADP} , {malonyl-CoA} , {phosphate}
 
 acetyl-CoA hydrolase [acetate] + [coenzyme A] ↔ [acetyl-CoA];   {ACH1} , {acetate} , {coenzyme A} , {acetyl-CoA}
 
 acetylglutamate kinase [ATP] + [N-acetyl-L-glutamate] ↔ [ADP] + [N-acetyl-L-gamma-glutamyl phosphate];   {ARG5,6} , {ATP} , {N-acetyl-L-glutamate} , {ADP} , {N-acetyl-L-gamma-glutamyl phosphate}
 
 acteylornithine transaminase [2-acetamido-5-oxopentanoate] + [L-glutamate] ↔ [2-oxoglutarate] + [N(2)-acetyl-L-ornithine];   {ARG8} , {2-acetamido-5-oxopentanoate} , {L-glutamate} , {2-oxoglutarate} , {N(2)-acetyl-L-ornithine}
 
 adenosine kinase [adenosine] + [ATP] ↔ [ADP] + [AMP];   {ADO1} , {adenosine} , {ATP} , {ADP} , {AMP}
 
 adenosylhomocysteinase [S-adenosyl-L-homocysteine] ↔ [adenosine] + [L-homocysteine];   {SAH1} , {S-adenosyl-L-homocysteine} , {adenosine} , {L-homocysteine}
 
 adenylate kinase [AMP] + [ATP] ↔ 2.0 × [ADP];   {ADK1} , {ADK2} , {AMP} , {ATP} , {ADP}
 
 adenylosuccinate lyase (AICAR) [5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole] ↔ [AICAR] + [fumarate];   {ADE13} , {5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole} , {AICAR} , {fumarate}
 
 adenylosuccinate lyase [adenylo-succinate] ↔ [AMP] + [fumarate];   {ADE13} , {adenylo-succinate} , {AMP} , {fumarate}
 
 adenylosuccinate synthase [GTP] + [IMP] + [L-aspartate] ↔ [adenylo-succinate] + [GDP] + [phosphate];   {ADE12} , {GTP} , {IMP} , {L-aspartate} , {adenylo-succinate} , {GDP} , {phosphate}
 
 adenylyl-sulfate kinase [5'-adenylyl sulfate] + [ATP] ↔ [3'-phospho-5'-adenylyl sulfate] + [ADP];   {MET14} , {5'-adenylyl sulfate} , {ATP} , {3'-phospho-5'-adenylyl sulfate} , {ADP}
 
 alanyl-tRNA synthetase [ATP] + [L-alanine] + [tRNA(Ala)] ↔ [Ala-tRNA(Ala)] + [AMP] + [diphosphate];   {ALA1} , {ATP} , {L-alanine} , {tRNA(Ala)} , {Ala-tRNA(Ala)} , {AMP} , {diphosphate}
 
 alpha,alpha-trehalose-phosphate synthase (UDP-forming) [D-glucose 6-phosphate] + [UDP-D-glucose] ↔ [alpha,alpha-trehalose 6-phosphate] + [UDP];   {TSL1} , {TPS1} , {TPS2} , {TPS3} , {D-glucose 6-phosphate} , {UDP-D-glucose} , {alpha,alpha-trehalose 6-phosphate} , {UDP}
 
 anthranilate phosphoribosyltransferase [anthranilate] + [PRPP] ↔ [diphosphate] + [N-(5-phospho-beta-D-ribosyl)anthranilate];   {TRP4} , {anthranilate} , {PRPP} , {diphosphate} , {N-(5-phospho-beta-D-ribosyl)anthranilate}
 
 anthranilate synthase [chorismate] + [L-glutamine] ↔ [anthranilate] + [L-glutamate] + [pyruvate];   {TRP2} , {TRP3} , {chorismate} , {L-glutamine} , {anthranilate} , {L-glutamate} , {pyruvate}
 
 argininosuccinate lyase [(N(omega)-L-arginino)succinic acid] ↔ [fumarate] + [L-arginine];   {ARG4} , {(N(omega)-L-arginino)succinic acid} , {fumarate} , {L-arginine}
 
 argininosuccinate synthase [ATP] + [L-aspartate] + [L-citrulline] ↔ [(N(omega)-L-arginino)succinic acid] + [AMP] + [diphosphate];   {ARG1} , {ATP} , {L-aspartate} , {L-citrulline} , {(N(omega)-L-arginino)succinic acid} , {AMP} , {diphosphate}
 
 arginyl-tRNA synthetase [ATP] + [L-arginine] + [tRNA(Arg)] ↔ [AMP] + [Arg-tRNA(Arg)] + [diphosphate];   {YDR341C} , {ATP} , {L-arginine} , {tRNA(Arg)} , {AMP} , {Arg-tRNA(Arg)} , {diphosphate}
 
 asparagine synthase (glutamine-hydrolysing) [ATP] + [L-aspartate] + [L-glutamine] ↔ [AMP] + [diphosphate] + [L-asparagine] + [L-glutamate];   {ASN1} , {ASN2} , {ATP} , {L-aspartate} , {L-glutamine} , {AMP} , {diphosphate} , {L-asparagine} , {L-glutamate}
 
 Asparaginyl-tRNA synthetase [ATP] + [L-asparagine] + [tRNA(Asn)] ↔ [AMP] + [Asn-tRNA(Asn)] + [diphosphate];   {DED81} , {ATP} , {L-asparagine} , {tRNA(Asn)} , {AMP} , {Asn-tRNA(Asn)} , {diphosphate}
 
 aspartate carbamoyltransferase [carbamoyl phosphate] + [L-aspartate] ↔ [N-carbamoyl-L-aspartate] + [phosphate];   {URA2} , {carbamoyl phosphate} , {L-aspartate} , {N-carbamoyl-L-aspartate} , {phosphate}
 
 aspartate kinase [ATP] + [L-aspartate] ↔ [4-phospho-L-aspartate] + [ADP];   {HOM3} , {ATP} , {L-aspartate} , {4-phospho-L-aspartate} , {ADP}
 
 aspartate transaminase [L-glutamate] + [oxaloacetate] ↔ [2-oxoglutarate] + [L-aspartate];   {AAT2} , {AAT1} , {L-glutamate} , {oxaloacetate} , {2-oxoglutarate} , {L-aspartate}
 
 aspartate-semialdehyde dehydrogenase [4-phospho-L-aspartate] + [NADPH] ↔ [L-aspartate 4-semialdehyde] + [NADP(+)] + [phosphate];   {HOM2} , {4-phospho-L-aspartate} , {NADPH} , {L-aspartate 4-semialdehyde} , {NADP(+)} , {phosphate}
 
 Aspartyl-tRNA synthetase [ATP] + [L-aspartate] + [tRNA(Asp)] ↔ [AMP] + [Asp-tRNA(Asp)] + [diphosphate];   {DPS1} , {ATP} , {L-aspartate} , {tRNA(Asp)} , {AMP} , {Asp-tRNA(Asp)} , {diphosphate}
 
 ATP phosphoribosyltransferase [ATP] + [PRPP] ↔ [5-phosphoribosyl-ATP] + [diphosphate];   {HIS1} , {ATP} , {PRPP} , {5-phosphoribosyl-ATP} , {diphosphate}
 
 C-14 sterol reductase [4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol] + [NADPH] ↔ [14-demethyllanosterol] + [NADP(+)];   {ERG24} , {4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol} , {NADPH} , {14-demethyllanosterol} , {NADP(+)}
 
 C-22 sterol desaturase (NADP) [ergosta-5,7,24(28)-trien-3beta-ol] + [NADPH] + [oxygen] ↔ [ergosta-5,7,22,24(28)-tetraen-3beta-ol] + [NADP(+)];   {ERG5} , {ergosta-5,7,24(28)-trien-3beta-ol} , {NADPH} , {oxygen} , {ergosta-5,7,22,24(28)-tetraen-3beta-ol} , {NADP(+)}
 
 C-3 sterol dehydrogenase [NADP(+)] + [zymosterol intermediate 1c] ↔ [carbon dioxide] + [NADPH] + [zymosterol intermediate 2];   {ERG26} , {NADP(+)} , {zymosterol intermediate 1c} , {carbon dioxide} , {NADPH} , {zymosterol intermediate 2}
 
 C-3 sterol dehydrogenase (4-methylzymosterol) [4beta-methylzymosterol-4alpha-carboxylic acid] + [NAD] ↔ [3-dehydro-4-methylzymosterol] + [carbon dioxide] + [NADH];   {ERG26} , {4beta-methylzymosterol-4alpha-carboxylic acid} , {NAD} , {3-dehydro-4-methylzymosterol} , {carbon dioxide} , {NADH}
 
 C-3 sterol keto reductase (4-methylzymosterol) [3-dehydro-4-methylzymosterol] + [NADPH] ↔ [4alpha-methylzymosterol] + [NADP(+)];   {ERG27} , {3-dehydro-4-methylzymosterol} , {NADPH} , {4alpha-methylzymosterol} , {NADP(+)}
 
 C-3 sterol keto reductase (zymosterol) [NADPH] + [zymosterol intermediate 2] ↔ [NADP(+)] + [zymosterol];   {ERG27} , {NADPH} , {zymosterol intermediate 2} , {NADP(+)} , {zymosterol}
 
 C-4 methyl sterol oxidase [4alpha-methylzymosterol] + [NADPH] + [oxygen] ↔ [NADP(+)] + [zymosterol intermediate 1a];   {ERG25} , {4alpha-methylzymosterol} , {NADPH} , {oxygen} , {NADP(+)} , {zymosterol intermediate 1a}
 
 C-4 methyl sterol oxidase [NADPH] + [oxygen] + [zymosterol intermediate 1a] ↔ [NADP(+)] + [zymosterol intermediate 1b];   {ERG25} , {NADPH} , {oxygen} , {zymosterol intermediate 1a} , {NADP(+)} , {zymosterol intermediate 1b}
 
 C-4 methyl sterol oxidase [NADPH] + [oxygen] + [zymosterol intermediate 1b] ↔ [NADP(+)] + [zymosterol intermediate 1c];   {ERG25} , {NADPH} , {oxygen} , {zymosterol intermediate 1b} , {NADP(+)} , {zymosterol intermediate 1c}
 
 C-4 sterol methyl oxidase (4,4-dimethylzymosterol) [14-demethyllanosterol] + 3.0 × [NADPH] + 3.0 × [oxygen] ↔ [4beta-methylzymosterol-4alpha-carboxylic acid] + 3.0 × [NADP(+)];   {ERG25} , {14-demethyllanosterol} , {NADPH} , {oxygen} , {4beta-methylzymosterol-4alpha-carboxylic acid} , {NADP(+)}
 
 C-5 sterol desaturase [episterol] + [NADPH] + [oxygen] ↔ [ergosta-5,7,24(28)-trien-3beta-ol] + [NADP(+)];   {ERG3} , {episterol} , {NADPH} , {oxygen} , {ergosta-5,7,24(28)-trien-3beta-ol} , {NADP(+)}
 
 C-8 sterol isomerase [fecosterol] ↔ [episterol];   {ERG2} , {fecosterol} , {episterol}
 
 C-s24 sterol reductase [ergosta-5,7,22,24(28)-tetraen-3beta-ol] + [NADPH] ↔ [ergosterol] + [NADP(+)];   {ERG4} , {ergosta-5,7,22,24(28)-tetraen-3beta-ol} , {NADPH} , {ergosterol} , {NADP(+)}
 
 carbamoyl-phosphate synthase (glutamine-hydrolysing) 2.0 × [ATP] + [bicarbonate] + [L-glutamine] ↔ 2.0 × [ADP] + [carbamoyl phosphate] + [L-glutamate] + [phosphate];   {URA2} , {CPA2} , {CPA1} , {ATP} , {bicarbonate} , {L-glutamine} , {ADP} , {carbamoyl phosphate} , {L-glutamate} , {phosphate}
 
 CDP-diacylglycerol synthase [CTP] + [phosphatidate] ↔ [CDP-diacylglycerol] + [diphosphate];   {CDS1} , {CTP} , {phosphatidate} , {CDP-diacylglycerol} , {diphosphate}
 
 ceramide-1 hydroxylase (24C) [ceramide-1 (C24)] + [NADPH] + [oxygen] ↔ [ceramide-2 (C24)] + [NADP(+)];   {SUR2} , {ceramide-1 (C24)} , {NADPH} , {oxygen} , {ceramide-2 (C24)} , {NADP(+)}
 
 ceramide-3 synthase (24C) [ceramide-2 (C24)] + [NADPH] + [oxygen] ↔ [ceramide-3 (C24)] + [NADP(+)];   {SCS7} , {ceramide-2 (C24)} , {NADPH} , {oxygen} , {ceramide-3 (C24)} , {NADP(+)}
 
 ceramide-4 synthase (24C) [ceramide-3 (C24)] + [NADPH] + [oxygen] ↔ [ceramide-4 (C24)] + [NADP(+)];   {SCS7} , {ceramide-3 (C24)} , {NADPH} , {oxygen} , {ceramide-4 (C24)} , {NADP(+)}
 
 chorismate mutase [chorismate] ↔ [prephenate];   {ARO7} , {chorismate} , {prephenate}
 
 chorismate synthase [5-O-(1-carboxyvinyl)-3-phosphoshikimic acid] ↔ [chorismate] + [phosphate];   {ARO2} , {5-O-(1-carboxyvinyl)-3-phosphoshikimic acid} , {chorismate} , {phosphate}
 
 cis-aconitate(3-) to isocitrate [cis-aconitate] ↔ [isocitrate];   {ACO1} , {cis-aconitate} , {isocitrate}
 
 citrate synthase [acetyl-CoA] + [oxaloacetate] ↔ [citrate] + [coenzyme A];   {CIT3} , {CIT1} , {CIT2} , {acetyl-CoA} , {oxaloacetate} , {citrate} , {coenzyme A}
 
 citrate to cis-aconitate(3-) [citrate] ↔ [cis-aconitate];   {ACO1} , {citrate} , {cis-aconitate}
 
 CTP synthase (NH3) [ammonium] + [ATP] + [UTP] ↔ [ADP] + [CTP] + [phosphate];   {URA8} , {URA7} , {ammonium} , {ATP} , {UTP} , {ADP} , {CTP} , {phosphate}
 
 cystathionine beta-synthase [L-homocysteine] + [L-serine] ↔ [L-cystathionine];   {CYS4} , {L-homocysteine} , {L-serine} , {L-cystathionine}
 
 cystathionine g-lyase [L-cystathionine] ↔ [2-oxobutanoate] + [ammonium] + [L-cysteine];   {CYS3} , {L-cystathionine} , {2-oxobutanoate} , {ammonium} , {L-cysteine}
 
 cystathionine gamma-synthase [L-cysteine] + [O-acetyl-L-homoserine] ↔ [acetate] + [L-cystathionine];   {STR2} , {L-cysteine} , {O-acetyl-L-homoserine} , {acetate} , {L-cystathionine}
 
 cysteinyl-tRNA synthetase [ATP] + [L-cysteine] + [tRNA(Cys)] ↔ [AMP] + [Cys-tRNA(Cys)] + [diphosphate];   {YNL247W} , {ATP} , {L-cysteine} , {tRNA(Cys)} , {AMP} , {Cys-tRNA(Cys)} , {diphosphate}
 
 cytochrome P450 lanosterol 14-alpha-demethylase (NADP) [lanosterol] + 3.0 × [NADPH] + 3.0 × [oxygen] ↔ [4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol] + [formate] + 3.0 × [NADP(+)];   {NCP1} , {ERG11} , {lanosterol} , {NADPH} , {oxygen} , {4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol} , {formate} , {NADP(+)}
 
 dCMP deaminase [dCMP] ↔ [ammonium] + [dUMP];   {DCD1} , {dCMP} , {ammonium} , {dUMP}
 
 deoxyguanylate kinase (dGMP:ATP) [ADP] + [dGDP] ↔ [ATP] + [dGMP];   {GUK1} , {ADP} , {dGDP} , {ATP} , {dGMP}
 
 diacylglycerol acyltransferase [coenzyme A] + [triglyceride] ↔ [acyl-CoA] + [diglyceride];   {DGA1} , {coenzyme A} , {triglyceride} , {acyl-CoA} , {diglyceride}
 
 diacylglycerol pyrophosphate phosphatase [phosphatidate] ↔ [diglyceride] + [phosphate];   {DPP1} , {phosphatidate} , {diglyceride} , {phosphate}
 
 dihydoorotic acid dehydrogenase [(S)-dihydroorotate] + [oxygen] ↔ [hydrogen peroxide] + [orotate];   {URA1} , {(S)-dihydroorotate} , {oxygen} , {hydrogen peroxide} , {orotate}
 
 dihydroceramidase [lignoceric acid] + [sphinganine] ↔ [ceramide-1 (C24)];   {YDC1} , {lignoceric acid} , {sphinganine} , {ceramide-1 (C24)}
 
 dihydrofolate reductase [dihydrofolic acid] + [NADPH] ↔ [NADP(+)] + [THF];   {DFR1} , {dihydrofolic acid} , {NADPH} , {NADP(+)} , {THF}
 
 dihydroorotase [N-carbamoyl-L-aspartate] ↔ [(S)-dihydroorotate];   {URA4} , {N-carbamoyl-L-aspartate} , {(S)-dihydroorotate}
 
 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) [(R)-2,3-dihydroxy-3-methylbutanoate] ↔ [3-methyl-2-oxobutanoate];   {ILV3} , {(R)-2,3-dihydroxy-3-methylbutanoate} , {3-methyl-2-oxobutanoate}
 
 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) [(2R,3R)-2,3-dihydroxy-3-methylpentanoate] ↔ [(S)-3-methyl-2-oxopentanoate];   {ILV3} , {(2R,3R)-2,3-dihydroxy-3-methylpentanoate} , {(S)-3-methyl-2-oxopentanoate}
 
 dimethylallyltranstransferase [isopentenyl diphosphate] + [prenyl diphosphate] ↔ [diphosphate] + [geranyl diphosphate];   {ERG20} , {isopentenyl diphosphate} , {prenyl diphosphate} , {diphosphate} , {geranyl diphosphate}
 
 dolichyl-phosphate D-mannosyltransferase [dolichyl phosphate] + [GDP-alpha-D-mannose] ↔ [dolichyl D-mannosyl phosphate] + [GDP];   {DPM1} , {dolichyl phosphate} , {GDP-alpha-D-mannose} , {dolichyl D-mannosyl phosphate} , {GDP}
 
 dolichyl-phosphate-mannose--protein mannosyltransferase [dolichyl D-mannosyl phosphate] ↔ [dolichyl phosphate] + [mannan];   {PMT5} , {PMT4} , {PMT2} , {PMT3} , {PMT1} , {dolichyl D-mannosyl phosphate} , {dolichyl phosphate} , {mannan}
 
 dUTP diphosphatase [dUTP] ↔ [diphosphate] + [dUMP];   {DUT1} , {dUTP} , {diphosphate} , {dUMP}
 
 enolase [2-phospho-D-glyceric acid] ↔ [phosphoenolpyruvate];   {ENO1} , {ENO2} , {2-phospho-D-glyceric acid} , {phosphoenolpyruvate}
 
 fatty acid synthase (n-C12:0) [decanoate] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [laurate] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {decanoate} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {laurate} , {NADP(+)}
 
 fatty acid synthase (n-C14:0) [laurate] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [myristate] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {laurate} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {myristate} , {NADP(+)}
 
 fatty acid synthase (n-C16:0) [malonyl-CoA] + [myristate] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [palmitate];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {myristate} , {NADPH} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {palmitate}
 
 fatty acid synthase (n-C18:0) [malonyl-CoA] + 2.0 × [NADPH] + [palmitate] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [stearate];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {NADPH} , {palmitate} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {stearate}
 
 fatty acid synthase (n-C24:0), lumped reaction 3.0 × [malonyl-CoA] + 6.0 × [NADPH] + [stearate] ↔ 3.0 × [carbon dioxide] + 3.0 × [coenzyme A] + [lignoceric acid] + 6.0 × [NADP(+)];   {TSC13} , {FEN1} , {SUR4} , {malonyl-CoA} , {NADPH} , {stearate} , {carbon dioxide} , {coenzyme A} , {lignoceric acid} , {NADP(+)}
 
 fatty acyl-CoA synthase (n-C10:0CoA) [malonyl-CoA] + 2.0 × [NADPH] + [octanoyl-CoA] ↔ [carbon dioxide] + [coenzyme A] + [decanoyl-CoA] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {NADPH} , {octanoyl-CoA} , {carbon dioxide} , {coenzyme A} , {decanoyl-CoA} , {NADP(+)}
 
 fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction [acetyl-CoA] + 3.0 × [malonyl-CoA] + 6.0 × [NADPH] ↔ 3.0 × [carbon dioxide] + 3.0 × [coenzyme A] + 6.0 × [NADP(+)] + [octanoyl-CoA];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {acetyl-CoA} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {octanoyl-CoA}
 
 fatty-acid--CoA ligase (decanoate) [AMP] + [decanoyl-CoA] + [diphosphate] ↔ [ATP] + [coenzyme A] + [decanoate];   {FAA2} , {AMP} , {decanoyl-CoA} , {diphosphate} , {ATP} , {coenzyme A} , {decanoate}
 
 fatty-acid--CoA ligase (dodecanoate) [AMP] + [diphosphate] + [lauroyl-CoA] ↔ [ATP] + [coenzyme A] + [laurate];   {FAA2} , {AMP} , {diphosphate} , {lauroyl-CoA} , {ATP} , {coenzyme A} , {laurate}
 
 fatty-acid--CoA ligase (octadecanoate) [AMP] + [diphosphate] + [stearoyl-CoA] ↔ [ATP] + [coenzyme A] + [stearate];   {FAA4} , {FAA1} , {FAA3} , {AMP} , {diphosphate} , {stearoyl-CoA} , {ATP} , {coenzyme A} , {stearate}
 
 fatty-acyl-CoA synthase (n-C12:0CoA) [decanoyl-CoA] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [lauroyl-CoA] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {decanoyl-CoA} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {lauroyl-CoA} , {NADP(+)}
 
 fatty-acyl-CoA synthase (n-C14:0CoA) [lauroyl-CoA] + [malonyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + [myristoyl-CoA] + 2.0 × [NADP(+)];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {lauroyl-CoA} , {malonyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {myristoyl-CoA} , {NADP(+)}
 
 fatty-acyl-CoA synthase (n-C16:0CoA) [malonyl-CoA] + [myristoyl-CoA] + 2.0 × [NADPH] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [palmitoyl-CoA];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {myristoyl-CoA} , {NADPH} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {palmitoyl-CoA}
 
 fatty-acyl-CoA synthase (n-C18:0CoA) [malonyl-CoA] + 2.0 × [NADPH] + [palmitoyl-CoA] ↔ [carbon dioxide] + [coenzyme A] + 2.0 × [NADP(+)] + [stearoyl-CoA];   {ACC1} , {ACB1} , {FAS1} , {FAS2} , {malonyl-CoA} , {NADPH} , {palmitoyl-CoA} , {carbon dioxide} , {coenzyme A} , {NADP(+)} , {stearoyl-CoA}
 
 ferrocytochrome-c:oxygen oxidoreductase 4.0 × [ferrocytochrome c] + [oxygen] ↔ 4.0 × [ferricytochrome c];   {COX12} , {COX3} , {COX5A} , {COX6} , {COX9} , {COX1} , {COX13} , {CYC7} , {COX7} , {COX8} , {COX2} , {CYC1} , {COX4} , {COX5B} , {ferrocytochrome c} , {oxygen} , {ferricytochrome c}
 
 ferrocytochrome-c:oxygen oxidoreductase 2.0 × [ferricytochrome c] + [ubiquinol-6] ↔ 2.0 × [ferrocytochrome c] + [ubiquinone-6];   {QCR8} , {QCR2} , {QCR10} , {RIP1} , {COB} , {QCR7} , {QCR9} , {CYC7} , {CYT1} , {COR1} , {CYC1} , {QCR6} , {ferricytochrome c} , {ubiquinol-6} , {ferrocytochrome c} , {ubiquinone-6}
 
 formate-tetrahydrofolate ligase [10-formyl-THF] + [ADP] + [phosphate] ↔ [ATP] + [formate] + [THF];   {ADE3} , {MIS1} , {10-formyl-THF} , {ADP} , {phosphate} , {ATP} , {formate} , {THF}
 
 fructose-bisphosphate aldolase [D-fructose 1,6-bisphosphate] ↔ [dihydroxyacetone phosphate] + [glyceraldehyde 3-phosphate];   {FBA1} , {D-fructose 1,6-bisphosphate} , {dihydroxyacetone phosphate} , {glyceraldehyde 3-phosphate}
 
 fumarase [fumarate] ↔ [(S)-malate];   {FUM1} , {fumarate} , {(S)-malate}
 
 geranyltranstransferase [geranyl diphosphate] + [isopentenyl diphosphate] ↔ [farnesyl diphosphate] + [diphosphate];   {ERG20} , {geranyl diphosphate} , {isopentenyl diphosphate} , {farnesyl diphosphate} , {diphosphate}
 
 glucose-6-phosphate isomerase [D-glucose 6-phosphate] ↔ [D-fructose 6-phosphate];   {PGI1} , {D-glucose 6-phosphate} , {D-fructose 6-phosphate}
 
 glutamate dehydrogenase (NAD) [2-oxoglutarate] + [ammonium] + [NADH] ↔ [L-glutamate] + [NAD];   {GDH2} , {2-oxoglutarate} , {ammonium} , {NADH} , {L-glutamate} , {NAD}
 
 glutamate dehydrogenase (NADP) [2-oxoglutarate] + [ammonium] + [NADPH] ↔ [L-glutamate] + [NADP(+)];   {GDH3} , {GDH1} , {2-oxoglutarate} , {ammonium} , {NADPH} , {L-glutamate} , {NADP(+)}
 
 glutamine synthetase [ammonium] + [ATP] + [L-glutamate] ↔ [ADP] + [L-glutamine] + [phosphate];   {GLN1} , {ammonium} , {ATP} , {L-glutamate} , {ADP} , {L-glutamine} , {phosphate}
 
 glutaminyl-tRNA synthetase [ATP] + [L-glutamine] + [tRNA(Gln)] ↔ [AMP] + [diphosphate] + [Gln-tRNA(Gln)];   {GLN4} , {ATP} , {L-glutamine} , {tRNA(Gln)} , {AMP} , {diphosphate} , {Gln-tRNA(Gln)}
 
 glutamyl-tRNA synthetase [ATP] + [L-glutamate] + [tRNA(Glu)] ↔ [AMP] + [diphosphate] + [Glu-tRNA(Glu)];   {GUS1} , {ATP} , {L-glutamate} , {tRNA(Glu)} , {AMP} , {diphosphate} , {Glu-tRNA(Glu)}
 
 glutathione oxidoreductase [glutathione disulfide] + [NADPH] ↔ 2.0 × [glutathione] + [NADP(+)];   {GRX2} , {GRX1} , {GRX3} , {GRX4} , {GLR1} , {GRX5} , {glutathione disulfide} , {NADPH} , {glutathione} , {NADP(+)}
 
 glutathione peridoxase 2.0 × [glutathione] + [hydrogen peroxide] ↔ [glutathione disulfide];   {GRX2} , {GPX1} , {GPX2} , {GRX1} , {HYR1} , {GRX5} , {glutathione} , {hydrogen peroxide} , {glutathione disulfide}
 
 glyceraldehyde-3-phosphate dehydrogenase [glyceraldehyde 3-phosphate] + [NAD] + [phosphate] ↔ [1,3-bisphospho-D-glycerate] + [NADH];   {TDH3} , {TDH1} , {TDH2} , {glyceraldehyde 3-phosphate} , {NAD} , {phosphate} , {1,3-bisphospho-D-glycerate} , {NADH}
 
 glycerol-3-phosphate dehydrogenase (NAD) [dihydroxyacetone phosphate] + [NADH] ↔ [glycerol 3-phosphate] + [NAD];   {GPD1} , {GPD2} , {dihydroxyacetone phosphate} , {NADH} , {glycerol 3-phosphate} , {NAD}
 
 glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase [acyl-CoA] + [glycerol 3-phosphate] ↔ [1-acyl-sn-glycerol 3-phosphate] + [coenzyme A];   {SCT1} , {GPT2} , {acyl-CoA} , {glycerol 3-phosphate} , {1-acyl-sn-glycerol 3-phosphate} , {coenzyme A}
 
 glycinamide ribotide transformylase [10-formyl-THF] + [5-phospho-ribosyl-glycineamide] ↔ [5'-phosphoribosyl-N-formylglycineamide] + [THF];   {ADE8} , {10-formyl-THF} , {5-phospho-ribosyl-glycineamide} , {5'-phosphoribosyl-N-formylglycineamide} , {THF}
 
 glycine cleavage system [L-glycine] + [NAD] + [THF] ↔ [5,10-methylenetetrahydrofolate] + [ammonium] + [carbon dioxide] + [NADH];   {GCV2} , {GCV3} , {GCV1} , {LPD1} , {L-glycine} , {NAD} , {THF} , {5,10-methylenetetrahydrofolate} , {ammonium} , {carbon dioxide} , {NADH}
 
 glycine hydroxymethyltransferase [L-serine] + [THF] ↔ [5,10-methylenetetrahydrofolate] + [L-glycine];   {SHM2} , {SHM1} , {L-serine} , {THF} , {5,10-methylenetetrahydrofolate} , {L-glycine}
 
 glycogen (starch) synthase [UDP-D-glucose] ↔ [glycogen] + [UDP];   {GSY2} , {GLG2} , {GSY1} , {GLG1} , {UDP-D-glucose} , {glycogen} , {UDP}
 
 glycyl-tRNA synthetase [ATP] + [L-glycine] + [tRNA(Gly)] ↔ [AMP] + [diphosphate] + [Gly-tRNA(Gly)];   {GRS1} , {GRS2} , {ATP} , {L-glycine} , {tRNA(Gly)} , {AMP} , {diphosphate} , {Gly-tRNA(Gly)}
 
 GMP synthase [ATP] + [L-glutamine] + [xanthosine-5-phosphate] ↔ [AMP] + [diphosphate] + [GMP] + [L-glutamate];   {GUA1} , {ATP} , {L-glutamine} , {xanthosine-5-phosphate} , {AMP} , {diphosphate} , {GMP} , {L-glutamate}
 
 GTP cyclohydrolase II [GTP] ↔ [2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine] + [diphosphate] + [formate];   {RIB1} , {GTP} , {2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine} , {diphosphate} , {formate}
 
 guanylate kinase [ATP] + [GMP] ↔ [ADP] + [GDP];   {GUK1} , {ATP} , {GMP} , {ADP} , {GDP}
 
 guanylate kinase (GMP:dATP) [dATP] + [GMP] ↔ [dADP] + [GDP];   {GUK1} , {dATP} , {GMP} , {dADP} , {GDP}
 
 hexokinase (D-glucose:ATP) [ATP] + [D-glucose] ↔ [ADP] + [D-glucose 6-phosphate];   {GLK1} , {HXK1} , {HXK2} , {ATP} , {D-glucose} , {ADP} , {D-glucose 6-phosphate}
 
 histidinol dehydrogenase [L-histidinol] + 2.0 × [NAD] ↔ [L-histidine] + 2.0 × [NADH];   {HIS4} , {L-histidinol} , {NAD} , {L-histidine} , {NADH}
 
 histidinol-phosphatase [L-histidinol phosphate] ↔ [L-histidinol] + [phosphate];   {HIS2} , {L-histidinol phosphate} , {L-histidinol} , {phosphate}
 
 histidinol-phosphate transaminase [3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-histidinol phosphate];   {HIS5} , {3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate} , {L-glutamate} , {2-oxoglutarate} , {L-histidinol phosphate}
 
 histidyl-tRNA synthetase [ATP] + [L-histidine] + [tRNA(His)] ↔ [AMP] + [diphosphate] + [His-tRNA(His)];   {HTS1} , {ATP} , {L-histidine} , {tRNA(His)} , {AMP} , {diphosphate} , {His-tRNA(His)}
 
 homoacontinate hydratase [but-1-ene-1,2,4-tricarboxylic acid] ↔ [homoisocitrate];   {LYS4} , {but-1-ene-1,2,4-tricarboxylic acid} , {homoisocitrate}
 
 homocitrate synthase [2-oxoglutarate] + [acetyl-CoA] ↔ [coenzyme A] + [homocitrate];   {LYS20} , {LYS21} , {2-oxoglutarate} , {acetyl-CoA} , {coenzyme A} , {homocitrate}
 
 homoisocitrate dehydrogenase [homoisocitrate] + [NAD] ↔ [2-oxoadipic acid] + [NADH] + [carbon dioxide];   {LYS12} , {homoisocitrate} , {NAD} , {2-oxoadipic acid} , {NADH} , {carbon dioxide}
 
 homoserine dehydrogenase (NADP) [L-aspartate 4-semialdehyde] + [NADPH] ↔ [L-homoserine] + [NADP(+)];   {HOM6} , {L-aspartate 4-semialdehyde} , {NADPH} , {L-homoserine} , {NADP(+)}
 
 homoserine kinase [ATP] + [L-homoserine] ↔ [ADP] + [O-phospho-L-homoserine];   {THR1} , {ATP} , {L-homoserine} , {ADP} , {O-phospho-L-homoserine}
 
 homoserine O-trans-acetylase [acetyl-CoA] + [L-homoserine] ↔ [coenzyme A] + [O-acetyl-L-homoserine];   {MET2} , {acetyl-CoA} , {L-homoserine} , {coenzyme A} , {O-acetyl-L-homoserine}
 
 hydrogen peroxide reductase (thioredoxin) [hydrogen peroxide] + [TRX1] ↔ [TRX1 disulphide];   {TRX1} , {TRX2} , {TSA2} , {DOT5} , {AHP1} , {PRX1} , {TRX3} , {hydrogen peroxide} , {TRX1} , {TRX1 disulphide}
 
 hydroxymethylglutaryl CoA reductase [3-hydroxy-3-methylglutaryl-CoA] + 2.0 × [NADPH] ↔ [(R)-mevalonate] + [coenzyme A] + 2.0 × [NADP(+)];   {HMG2} , {HMG1} , {3-hydroxy-3-methylglutaryl-CoA} , {NADPH} , {(R)-mevalonate} , {coenzyme A} , {NADP(+)}
 
 hydroxymethylglutaryl CoA synthase [acetoacetyl-CoA] + [acetyl-CoA] ↔ [3-hydroxy-3-methylglutaryl-CoA] + [coenzyme A];   {ERG13} , {acetoacetyl-CoA} , {acetyl-CoA} , {3-hydroxy-3-methylglutaryl-CoA} , {coenzyme A}
 
 Imidazole-glycerol-3-phosphate synthase [5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide] + [L-glutamine] ↔ [AICAR] + [D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate] + [L-glutamate];   {HIS7} , {5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide} , {L-glutamine} , {AICAR} , {D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate} , {L-glutamate}
 
 imidazoleglycerol-phosphate dehydratase [D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate] ↔ [3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate];   {HIS3} , {D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate} , {3-(imidazol-4-yl)-2-oxopropyl dihydrogen phosphate}
 
 IMP dehydrogenase [IMP] + [NAD] ↔ [NADH] + [xanthosine-5-phosphate];   {IMD4} , {IMD2} , {IMD3} , {IMP} , {NAD} , {NADH} , {xanthosine-5-phosphate}
 
 indole-3-glycerol-phosphate synthase [1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate] ↔ [1-C-(indol-3-yl)glycerol 3-phosphate] + [carbon dioxide];   {TRP3} , {1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate} , {1-C-(indol-3-yl)glycerol 3-phosphate} , {carbon dioxide}
 
 inorganic diphosphatase [diphosphate] ↔ 2.0 × [phosphate];   {IPP1} , {PPA2} , {diphosphate} , {phosphate}
 
 inosine monophosphate cyclohydrolase [phosphoribosyl-formamido-carboxamide] ↔ [IMP];   {ADE16} , {ADE17} , {phosphoribosyl-formamido-carboxamide} , {IMP}
 
 IPC synthase [1-phosphatidyl-1D-myo-inositol] + [ceramide-4 (C24)] ↔ [diglyceride] + [inositol-P-ceramide D (C24)];   {AUR1} , {KEI1} , {1-phosphatidyl-1D-myo-inositol} , {ceramide-4 (C24)} , {diglyceride} , {inositol-P-ceramide D (C24)}
 
 isocitrate dehydrogenase (NAD+) [isocitrate] + [NAD] ↔ [2-oxoglutarate] + [carbon dioxide] + [NADH];   {IDH2} , {IDH1} , {isocitrate} , {NAD} , {2-oxoglutarate} , {carbon dioxide} , {NADH}
 
 isocitrate dehydrogenase (NADP+), peroxisomal [isocitrate] + [NADP(+)] ↔ [2-oxoglutarate] + [carbon dioxide] + [NADPH];   {IDP3} , {IDP1} , {isocitrate} , {NADP(+)} , {2-oxoglutarate} , {carbon dioxide} , {NADPH}
 
 isoleucine transaminase [(S)-3-methyl-2-oxopentanoate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-isoleucine];   {BAT2} , {BAT1} , {(S)-3-methyl-2-oxopentanoate} , {L-glutamate} , {2-oxoglutarate} , {L-isoleucine}
 
 isoleucyl-tRNA synthetase [ATP] + [L-isoleucine] + [tRNA(Ile)] ↔ [AMP] + [diphosphate] + [Ile-tRNA(Ile)];   {ILS1} , {ATP} , {L-isoleucine} , {tRNA(Ile)} , {AMP} , {diphosphate} , {Ile-tRNA(Ile)}
 
 isopentenyl-diphosphate D-isomerase [isopentenyl diphosphate] ↔ [prenyl diphosphate];   {IDI1} , {isopentenyl diphosphate} , {prenyl diphosphate}
 
 ketol-acid reductoisomerase (2-aceto-2-hydroxybutanoate) [(S)-2-acetyl-2-hydroxybutanoate] + [NADPH] ↔ [(2R,3R)-2,3-dihydroxy-3-methylpentanoate] + [NADP(+)];   {ILV5} , {(S)-2-acetyl-2-hydroxybutanoate} , {NADPH} , {(2R,3R)-2,3-dihydroxy-3-methylpentanoate} , {NADP(+)}
 
 L-alanine transaminase [L-glutamate] + [pyruvate] ↔ [2-oxoglutarate] + [L-alanine];   {ALT1} , {L-glutamate} , {pyruvate} , {2-oxoglutarate} , {L-alanine}
 
 L-aminoadipate-semialdehyde dehydrogenase (NADPH) [L-2-aminoadipate] + [NADPH] ↔ [L-allysine] + [NADP(+)];   {LYS2} , {LYS5} , {L-2-aminoadipate} , {NADPH} , {L-allysine} , {NADP(+)}
 
 lanosterol synthase [(S)-2,3-epoxysqualene] ↔ [lanosterol];   {ERG7} , {(S)-2,3-epoxysqualene} , {lanosterol}
 
 leucine transaminase [4-methyl-2-oxopentanoate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-leucine];   {BAT2} , {BAT1} , {4-methyl-2-oxopentanoate} , {L-glutamate} , {2-oxoglutarate} , {L-leucine}
 
 leucyl-tRNA synthetase [ATP] + [L-leucine] + [tRNA(Leu)] ↔ [AMP] + [diphosphate] + [Leu-tRNA(Leu)];   {CDC60} , {ATP} , {L-leucine} , {tRNA(Leu)} , {AMP} , {diphosphate} , {Leu-tRNA(Leu)}
 
 lysyl-tRNA synthetase [ATP] + [L-lysine] + [tRNA(Lys)] ↔ [AMP] + [diphosphate] + [Lys-tRNA(Lys)];   {KRS1} , {ATP} , {L-lysine} , {tRNA(Lys)} , {AMP} , {diphosphate} , {Lys-tRNA(Lys)}
 
 malate dehydrogenase [(S)-malate] + [NAD] ↔ [NADH] + [oxaloacetate];   {MDH1} , {MDH2} , {MDH3} , {(S)-malate} , {NAD} , {NADH} , {oxaloacetate}
 
 mannose-1-phosphate guanylyltransferase [D-mannose 1-phosphate] + [GTP] ↔ [diphosphate] + [GDP-alpha-D-mannose];   {PSA1} , {D-mannose 1-phosphate} , {GTP} , {diphosphate} , {GDP-alpha-D-mannose}
 
 mannose-6-phosphate isomerase [D-fructose 6-phosphate] ↔ [D-mannose 6-phosphate];   {PMI40} , {D-fructose 6-phosphate} , {D-mannose 6-phosphate}
 
 methenyltetrahydrifikate cyclohydrolase [5,10-methenyl-THF] ↔ [10-formyl-THF];   {MIS1} , {ADE3} , {5,10-methenyl-THF} , {10-formyl-THF}
 
 methionine adenosyltransferase [ATP] + [L-methionine] ↔ [diphosphate] + [phosphate] + [S-adenosyl-L-methionine];   {SAM2} , {SAM1} , {ATP} , {L-methionine} , {diphosphate} , {phosphate} , {S-adenosyl-L-methionine}
 
 methionine synthase [5-methyltetrahydrofolate] + [L-homocysteine] ↔ [L-methionine] + [THF];   {MET6} , {5-methyltetrahydrofolate} , {L-homocysteine} , {L-methionine} , {THF}
 
 methionyl-tRNA synthetase [ATP] + [L-methionine] + [tRNA(Met)] ↔ [AMP] + [diphosphate] + [Met-tRNA(Met)];   {MES1} , {ATP} , {L-methionine} , {tRNA(Met)} , {AMP} , {diphosphate} , {Met-tRNA(Met)}
 
 methylenetetrahydrofolate dehydrogenase (NAD) [5,10-methylenetetrahydrofolate] + [NAD] ↔ [5,10-methenyl-THF] + [NADH];   {MTD1} , {5,10-methylenetetrahydrofolate} , {NAD} , {5,10-methenyl-THF} , {NADH}
 
 methylenetetrahydrofolate dehydrogenase (NADP) [5,10-methylenetetrahydrofolate] + [NADP(+)] ↔ [5,10-methenyl-THF] + [NADPH];   {ADE3} , {MIS1} , {5,10-methylenetetrahydrofolate} , {NADP(+)} , {5,10-methenyl-THF} , {NADPH}
 
 mevalonate kinase (ctp) [(R)-mevalonate] + [CTP] ↔ [(R)-5-phosphomevalonic acid] + [CDP];   {ERG12} , {(R)-mevalonate} , {CTP} , {(R)-5-phosphomevalonic acid} , {CDP}
 
 mevalonate pyrophoshate decarboxylase [(R)-5-diphosphomevalonic acid] + [ATP] ↔ [ADP] + [carbon dioxide] + [isopentenyl diphosphate] + [phosphate];   {MVD1} , {(R)-5-diphosphomevalonic acid} , {ATP} , {ADP} , {carbon dioxide} , {isopentenyl diphosphate} , {phosphate}
 
 myo-inositol 1-phosphatase [1D-myo-inositol 1-phosphate] ↔ [myo-inositol] + [phosphate];   {INM2} , {INM1} , {1D-myo-inositol 1-phosphate} , {myo-inositol} , {phosphate}
 
 myo-inositol-1-phosphate synthase [D-glucose 6-phosphate] ↔ [1D-myo-inositol 1-phosphate];   {INO1} , {D-glucose 6-phosphate} , {1D-myo-inositol 1-phosphate}
 
 N-acetyl-g-glutamyl-phosphate reductase [N-acetyl-L-gamma-glutamyl phosphate] + [NADPH] ↔ [2-acetamido-5-oxopentanoate] + [NADP(+)] + [phosphate];   {ARG5,6} , {N-acetyl-L-gamma-glutamyl phosphate} , {NADPH} , {2-acetamido-5-oxopentanoate} , {NADP(+)} , {phosphate}
 
 NADH dehydrogenase, cytosolic/mitochondrial [NADH] + [ubiquinone-6] ↔ [NAD] + [ubiquinol-6];   {NDE2} , {NDE1} , {NDI1} , {NADH} , {ubiquinone-6} , {NAD} , {ubiquinol-6}
 
 nucleoside diphosphatase [CDP] ↔ [CMP] + [phosphate];   {YND1} , {CDP} , {CMP} , {phosphate}
 
 nucleoside diphosphate kinase [ATP] + [GDP] ↔ [ADP] + [GTP];   {YNK1} , {ATP} , {GDP} , {ADP} , {GTP}
 
 nucleoside-diphosphate kinase (ATP:UDP) [ATP] + [UDP] ↔ [ADP] + [UTP];   {YNK1} , {ATP} , {UDP} , {ADP} , {UTP}
 
 O-acetylhomoserine (thiol)-lyase [hydrogen sulfide] + [O-acetyl-L-homoserine] ↔ [acetate] + [L-homocysteine];   {MET17} , {hydrogen sulfide} , {O-acetyl-L-homoserine} , {acetate} , {L-homocysteine}
 
 ornithine carbamoyltransferase [carbamoyl phosphate] + [ornithine] ↔ [L-citrulline] + [phosphate];   {ARG3} , {carbamoyl phosphate} , {ornithine} , {L-citrulline} , {phosphate}
 
 ornithine transacetylase [L-glutamate] + [N(2)-acetyl-L-ornithine] ↔ [N-acetyl-L-glutamate] + [ornithine];   {ARG7} , {L-glutamate} , {N(2)-acetyl-L-ornithine} , {N-acetyl-L-glutamate} , {ornithine}
 
 orotate phosphoribosyltransferase [orotate] + [PRPP] ↔ [diphosphate] + [orotidine 5'-(dihydrogen phosphate)];   {URA10} , {URA5} , {orotate} , {PRPP} , {diphosphate} , {orotidine 5'-(dihydrogen phosphate)}
 
 orotidine-5'-phosphate decarboxylase [orotidine 5'-(dihydrogen phosphate)] ↔ [carbon dioxide] + [UMP];   {URA3} , {orotidine 5'-(dihydrogen phosphate)} , {carbon dioxide} , {UMP}
 
 phenylalanine transaminase [keto-phenylpyruvate] + [L-glutamate] ↔ [2-oxoglutarate] + [L-phenylalanine];   {ARO8} , {keto-phenylpyruvate} , {L-glutamate} , {2-oxoglutarate} , {L-phenylalanine}
 
 phenylalanyl-tRNA synthetase [ATP] + [L-phenylalanine] + [tRNA(Phe)] ↔ [AMP] + [diphosphate] + [Phe-tRNA(Phe)];   {FRS1} , {FRS2} , {ATP} , {L-phenylalanine} , {tRNA(Phe)} , {AMP} , {diphosphate} , {Phe-tRNA(Phe)}
 
 phopshoribosylaminoimidazole synthetase [5'-phosphoribosyl-N-formylglycineamidine] + [ATP] ↔ [5'-phosphoribosyl-5-aminoimidazole] + [ADP] + [phosphate];   {ADE5,7} , {5'-phosphoribosyl-N-formylglycineamidine} , {ATP} , {5'-phosphoribosyl-5-aminoimidazole} , {ADP} , {phosphate}
 
 phosphatidylethanolamine methyltransferase [phosphatidylethanolamine] + [S-adenosyl-L-methionine] ↔ [phosphatidyl-N-methylethanolamine] + [S-adenosyl-L-homocysteine];   {OPI3} , {CHO2} , {phosphatidylethanolamine} , {S-adenosyl-L-methionine} , {phosphatidyl-N-methylethanolamine} , {S-adenosyl-L-homocysteine}
 
 phosphatidylinositol synthase [CDP-diacylglycerol] + [myo-inositol] ↔ [1-phosphatidyl-1D-myo-inositol] + [CMP];   {PIS1} , {CDP-diacylglycerol} , {myo-inositol} , {1-phosphatidyl-1D-myo-inositol} , {CMP}
 
 phosphatidylserine decarboxylase [phosphatidyl-L-serine] ↔ [carbon dioxide] + [phosphatidylethanolamine];   {PSD1} , {PSD2} , {phosphatidyl-L-serine} , {carbon dioxide} , {phosphatidylethanolamine}
 
 phosphatidylserine synthase [CDP-diacylglycerol] + [L-serine] ↔ [CMP] + [phosphatidyl-L-serine];   {CHO1} , {CDP-diacylglycerol} , {L-serine} , {CMP} , {phosphatidyl-L-serine}
 
 phosphoadenylyl-sulfate reductase (thioredoxin) [3'-phospho-5'-adenylyl sulfate] + [TRX1] ↔ [adenosine 3',5'-bismonophosphate] + [sulphite] + [TRX1 disulphide];   {TRX1} , {MET16} , {TRX2} , {3'-phospho-5'-adenylyl sulfate} , {TRX1} , {adenosine 3',5'-bismonophosphate} , {sulphite} , {TRX1 disulphide}
 
 phosphofructokinase [ATP] + [D-fructose 6-phosphate] ↔ [ADP] + [D-fructose 1,6-bisphosphate];   {PFK1} , {PFK2} , {ATP} , {D-fructose 6-phosphate} , {ADP} , {D-fructose 1,6-bisphosphate}
 
 phosphoglucomutase [D-glucose 6-phosphate] ↔ [D-glucose 1-phosphate];   {PGM1} , {PGM3} , {PGM2} , {D-glucose 6-phosphate} , {D-glucose 1-phosphate}
 
 phosphoglycerate dehydrogenase [3-phosphoglycerate] + [NAD] ↔ [3-phospho-hydroxypyruvate] + [NADH];   {SER3} , {SER33} , {3-phosphoglycerate} , {NAD} , {3-phospho-hydroxypyruvate} , {NADH}
 
 phosphoglycerate kinase [1,3-bisphospho-D-glycerate] + [ADP] ↔ [3-phosphoglycerate] + [ATP];   {PGK1} , {1,3-bisphospho-D-glycerate} , {ADP} , {3-phosphoglycerate} , {ATP}
 
 phosphoglycerate mutase [3-phosphoglycerate] ↔ [2-phospho-D-glyceric acid];   {GPM1} , {3-phosphoglycerate} , {2-phospho-D-glyceric acid}
 
 phospholipid methyltransferase [phosphatidyl-N,N-dimethylethanolamine] + [S-adenosyl-L-methionine] ↔ [phosphatidylcholine] + [S-adenosyl-L-homocysteine];   {OPI3} , {phosphatidyl-N,N-dimethylethanolamine} , {S-adenosyl-L-methionine} , {phosphatidylcholine} , {S-adenosyl-L-homocysteine}
 
 phospholipid methyltransferase [phosphatidyl-N-methylethanolamine] + [S-adenosyl-L-methionine] ↔ [phosphatidyl-N,N-dimethylethanolamine] + [