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BIOMD0000000469 - Smallbone2013 - E.coli metabolic model with linlog rate law


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Reference Publication
Publication ID: 10.1089/ind.2013.000...
Messiha HL, Kent E, Malys N, Carroll KM, Mendes P, Smallbone K.
Large-Scale Metabolic Models: From Reconstruction to Differential Equations
Industrial Biotechnology
Manchester Centre for Integrative Systems Biology and School of Computer Science, University of Manchester, Manchester Institute of Biotechnology, Manchester, UK  [more]
Original Model: BIOMD0000000469.origin
Submitter: Kieran Smallbone
Submission ID: MODEL1302140001
Submission Date: 14 Feb 2013 10:52:55 UTC
Last Modification Date: 04 Apr 2014 15:04:41 UTC
Creation Date: 22 Nov 2011 00:00:00 UTC
Encoders:  Nick Juty
   Vijayalakshmi Chelliah
   Kieran Smallbone
set #1
bqbiol:hasTaxon Taxonomy Escherichia coli
bqbiol:isVersionOf Gene Ontology metabolic process
Gene Ontology organic substance biosynthetic process
Publication ID: 10.1089/ind.2013.000... Submission Date: 14 Feb 2013 10:52:55 UTC Last Modification Date: 04 Apr 2014 15:04:41 UTC Creation Date: 22 Nov 2011 00:00:00 UTC
Mathematical expressions
(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous) 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase 1-deoxy-D-xylulose 5-phosphate synthase 1-deoxy-D-xylulose reductoisomerase
1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1) 1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0) 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp) 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)
2-aceto-2-hydroxybutanoate synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2-dehydro-3-deoxy-phosphogluconate aldolase
2-dehydropantoate 2-reductase 2-isopropylmalate hydratase 2-isopropylmalate synthase 2-Oxo-4-methyl-3-carboxypentanoate decarboxylation
2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase 3',5'-bisphosphate nucleotidase 3,4-Dihydroxy-2-butanone-4-phosphate synthase 3-cis-2-trans-enoyl-CoA isomerase
3-dehydroquinate dehydratase, irreversible 3-dehydroquinate synthase 3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase
3-deoxy-D-manno-octulosonic acid transferase 3-deoxy-D-manno-octulosonic acid transferase 3-deoxy-manno-octulosonate cytidylyltransferase 3-deoxy-manno-octulosonate-8-phosphatase
3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) 3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA) 3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA) 3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)
3-hydroxyacyl-CoA dehydratase (3-hydroxyhexanoyl-CoA) 3-hydroxyacyl-CoA dehydratase (3-hydroxyoctanoyl-CoA) 3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA) 3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)
3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA) 3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA) 3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA) 3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)
3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA) 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) 3-isopropylmalate dehydratase 3-isopropylmalate dehydrogenase
3-methyl-2-oxobutanoate hydroxymethyltransferase 3-Oxo-glutaryl-[ACP] methyl ester dehydratase 3-Oxo-glutaryl-[ACP] methyl ester reductase 3-Oxo-glutaryl-[ACP] methyl ester synthase
3-Oxo-pimeloyl-[ACP] methyl ester dehydratase 3-Oxo-pimeloyl-[ACP] methyl ester reductase 3-Oxo-pimeloyl-[ACP] methyl ester synthase 3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:0)
3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0) 3-phosphoshikimate 1-carboxyvinyltransferase 4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous) 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
4-amino-2-methyl-5-phosphomethylpyrimidine synthetase 4-amino-4-deoxychorismate synthase 4-aminobenzoate synthase 5'-deoxyadenosine nuclosidase
5,10-methylenetetrahydrofolate reductase (NADH) 5-amino-6-(5-phosphoribosylamino)uracil reductase 6-hydroxymethyl-dihydropterin pyrophosphokinase 6-phosphogluconate dehydratase
6-phosphogluconolactonase 8-amino-7-oxononanoate synthase acetaldehyde dehydrogenase (acetylating) acetate kinase
acetolactate synthase acetyl-CoA C-acetyltransferase acetyl-CoA C-acyltransferase (butanoyl-CoA) (r) acetyl-CoA C-acyltransferase (decanoyl-CoA) (r)
acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r) acetyl-CoA C-acyltransferase (hexanoyl-CoA) (r) acetyl-CoA C-acyltransferase (octanoyl-CoA) (r) acetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)
acetyl-CoA carboxylase acetylglutamate kinase acetylornithine deacetylase acetylornithine transaminase
aconitase (half-reaction A, Citrate hydro-lyase) aconitase (half-reaction B, Isocitrate hydro-lyase) acyl-[acyl-carrier-protein] synthetase (n-C12:0) acyl-[acyl-carrier-protein] synthetase (n-C16:0)
acyl-[acyl-carrier-protein] synthetase (n-C16:1) acyl-CoA dehydrogenase (butanoyl-CoA) acyl-CoA dehydrogenase (decanoyl-CoA) acyl-CoA dehydrogenase (dodecanoyl-CoA)
acyl-CoA dehydrogenase (hexadecanoyl-CoA) acyl-CoA dehydrogenase (hexanoyl-CoA) acyl-CoA dehydrogenase (octanoyl-CoA) acyl-CoA dehydrogenase (tetradecanoyl-CoA)
adenosine kinase adenosylmethionine-8-amino-7-oxononanoate transaminase adenylate kinase adenylosuccinate lyase
adenylosuccinate synthase adenylsuccinate lyase adenylyl-sulfate kinase alanine racemase
anthranilate phosphoribosyltransferase anthranilate synthase arabinose-5-phosphate isomerase argininosuccinate lyase
argininosuccinate synthase asparagine synthetase aspartate 1-decarboxylase aspartate carbamoyltransferase
aspartate kinase aspartate transaminase aspartate-semialdehyde dehydrogenase ATP phosphoribosyltransferase
Biotin synthase bis-molybdenum cofactor synthase bis-molybdopterin guanine dinucleotide synthase bis-molybdopterin guanine dinucleotide synthase (single GDP)
Carbamate kinase CDP-diacylglycerol synthetase (n-C16:0) CDP-diacylglycerol synthetase (n-C16:1) chorismate mutase
Chorismate pyruvate lyase chorismate synthase citrate synthase coproporphyrinogen oxidase (O2 required)
CTP synthase (glutamine) cyclic pyranopterin monophosphate synthase cystathionine b-lyase cysteine synthase
cytidylate kinase (CMP) D-alanine-D-alanine ligase (reversible) dephospho-CoA kinase dethiobiotin synthase
diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp) diaminopimelate decarboxylase diaminopimelate epimerase dihydoorotic acid dehydrogenase (quinone8)
dihydrodipicolinate reductase (NADPH) dihydrodipicolinate synthase dihydrofolate reductase dihydrofolate synthase
dihydroneopterin aldolase reversible Dihydroneopterin triphosphate pyrophosphatase dihydroorotase dihydroorotic acid (menaquinone-8)
dihydropteroate synthase dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) dimethylallyltranstransferase
dTMP kinase dUTP diphosphatase enolase Enoylglutaryl-[ACP] methyl ester reductase
Enoylpimeloyl-[ACP] methyl ester reductase Erythronate 4-phosphate (4per) dehydrogenase Erythrose 4-phosphate dehydrogenase FAD reductase
fatty-acid-CoA thioesterase (dodecanoate) fatty-acid-CoA thioesterase (hexadecanoate) fatty-acid-CoA thioesterase (hexadecenoate) Ferrochelatase
FMN adenylyltransferase formate-tetrahydrofolate ligase fumarase GAR transformylase-T
geranyltranstransferase glucosamine-1-phosphate N-acetyltransferase glucose 6-phosphate dehydrogenase glucose-6-phosphate isomerase
glutamate 5-kinase glutamate dehydrogenase (NADP) glutamate racemase glutamate-1-semialdehyde aminotransferase
glutamate-5-semialdehyde dehydrogenase glutamine phosphoribosyldiphosphate amidotransferase glutamine synthetase glutamine-fructose-6-phosphate transaminase
glutamyl-tRNA reductase Glutamyl-tRNA synthetase glyceraldehyde-3-phosphate dehydrogenase glycerate kinase
glycerol-3-phosphate acyltransferase (C16:0) glycerol-3-phosphate acyltransferase (C16:1) glycerol-3-phosphate dehydrogenase (NADP) glycine C-acetyltransferase
glycine hydroxymethyltransferase, reversible Glycolaldehyde dehydrogenase Glycolate oxidase Glycolate oxidase
glyoxalate carboligase GMP synthase GTP cyclohydrolase I GTP cyclohydrolase II (25drapp)
guanylate kinase (GMP:ATP) HCO3 equilibration reaction hexokinase (D-fructose:ATP) hexokinase (D-glucose:ATP)
histidinol dehydrogenase histidinol-phosphatase histidinol-phosphate transaminase homoserine dehydrogenase (NADPH)
homoserine kinase homoserine O-succinyltransferase Hydroxybenzoate octaprenyltransferase hydroxymethylbilane synthase
Imidazole-glycerol-3-phosphate synthase imidazoleglycerol-phosphate dehydratase IMP cyclohydrolase IMP dehydrogenase
indole-3-glycerol-phosphate synthase ISC [2Fe-2S] regeneration ISC [2Fe-2S] Synthesis ISC [2Fe-2S] Synthesis II
ISC [2Fe-2S] Transfer ISC [4Fe-4S] Reduction ISC [4Fe-4S] Transfer ISC Cysteine desulfuration
isocitrate dehydrogenase (NADP) isoleucine transaminase ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate) ketol-acid reductoisomerase (2-Acetolactate)
L-alanine transaminase L-aspartate oxidase L-glutamate 5-semialdehyde dehydratase (spontaneous) L-threonine deaminase
L-threonine dehydrogenase leucine transaminase (irreversible) Lipid A disaccaride synthase malate dehydrogenase
malate oxidase Malonyl-CoA methyltransferase Malonyl-CoA-ACP transacylase methenyltetrahydrofolate cyclohydrolase
methionine adenosyltransferase methionine synthase methylenetetrahydrofolate dehydrogenase (NADP) MoaD sulfuration (nadh, assumed)
molybdenum cofactor synthase molybdopterin adenylyltransferase molybdopterin synthase molybdopterin synthase sulfurylase
murein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm) N-acetyl-g-glutamyl-phosphate reductase N-acetylglutamate synthase NAD kinase
NAD synthase (nh3) nicotinate-nucleotide adenylyltransferase nicotinate-nucleotide diphosphorylase (carboxylating) nucleoside-diphosphate kinase (ATP:CDP)
nucleoside-diphosphate kinase (ATP:dTDP) nucleoside-diphosphate kinase (ATP:GDP) nucleoside-diphosphate kinase (ATP:UDP) nucleoside-triphosphatase (ATP)
O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase O-succinylhomoserine lyase (L-cysteine) Octaprenyl pyrophosphate synthase Octaprenyl-hydroxybenzoate decarboxylase
ornithine carbamoyltransferase orotate phosphoribosyltransferase orotidine-5'-phosphate decarboxylase pantetheine-phosphate adenylyltransferase
pantothenate kinase pantothenate synthase phenylalanine transaminase Phosphatidylserine decarboxylase (n-C16:0)
Phosphatidylserine decarboxylase (n-C16:1) Phosphatidylserine syntase (n-C16:0) Phosphatidylserine syntase (n-C16:1) phospho-L-serine phosphatase (periplasmic)
phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate) phosphoadenylyl-sulfate reductase (thioredoxin) phosphoenolpyruvate carboxylase phosphoglucosamine mutase
phosphoglycerate dehydrogenase phosphoglycerate kinase phosphoglycerate mutase phosphomethylpyrimidine kinase
phosphopantothenate-cysteine ligase phosphopantothenoylcysteine decarboxylase phosphopentomutase phosphoribosyl-AMP cyclohydrolase
phosphoribosyl-ATP pyrophosphatase phosphoribosylaminoimidazole carboxylase phosphoribosylaminoimidazole carboxylase (mutase rxn) phosphoribosylaminoimidazole synthase
phosphoribosylaminoimidazolecarboxamide formyltransferase phosphoribosylaminoimidazolesuccinocarboxamide synthase phosphoribosylanthranilate isomerase (irreversible) phosphoribosylformylglycinamidine synthase
phosphoribosylglycinamide synthase phosphoribosylpyrophosphate synthetase phosphoserine transaminase phosphotransacetylase
Pimeloyl-[ACP] methyl ester esterase polyphosphate kinase porphobilinogen synthase prephenate dehydratase
prephenate dehydrogenase protoporphyrinogen oxidase (aerobic) purine-nucleoside phosphorylase (Adenosine) Pyridoxine 5'-phosphate synthase
pyrroline-5-carboxylate reductase pyruvate dehydrogenase pyruvate formate lyase pyruvate synthase
quinolinate synthase riboflavin kinase riboflavin synthase riboflavin synthase
ribonucleoside-triphosphate reductase (ATP) (flavodoxin) ribonucleoside-triphosphate reductase (CTP) (flavodoxin) ribonucleoside-triphosphate reductase (GTP) (flavodoxin) ribonucleoside-triphosphate reductase (UTP) (flavodoxin)
ribose-5-phosphate isomerase ribulose 5-phosphate 3-epimerase S-adenosylhomocysteine nucleosidase S-ribosylhomocysteine cleavage enzyme
serine O-acetyltransferase shikimate dehydrogenase shikimate kinase sirohydrochlorin dehydrogenase (NAD)
sirohydrochlorin ferrochelatase succinyl-CoA synthetase (ADP-forming) succinyl-diaminopimelate desuccinylase succinyldiaminopimelate transaminase
Sulfate adenyltransferase sulfite reductase (NADPH2) tartronate semialdehyde reductase Tetraacyldisaccharide 4'kinase
tetrahydrodipicolinate succinylase thiamine-phosphate diphosphorylase thiamine-phosphate kinase thiazole phosphate synthesis
thioredoxin reductase (NADPH) Threonine aldolase threonine synthase thymidylate synthase
transaldolase transketolase transketolase triose-phosphate isomerase
tryptophan synthase (indoleglycerol phosphate) Tryptophanase (L-tryptophan) tyrosine lyase tyrosine transaminase
UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase UDP-3-O-acetylglucosamine deacetylase UDP-N-acetylenolpyruvoylglucosamine reductase UDP-N-acetylglucosamine 1-carboxyvinyltransferase
UDP-N-acetylglucosamine acyltransferase UDP-N-acetylglucosamine diphosphorylase UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase UDP-N-acetylmuramoyl-L-alanine synthetase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase UDP-sugar hydrolase
UMP kinase Undecaprenyl diphosphate synthase undecaprenyl-diphosphatase uroporphyrinogen decarboxylase (uroporphyrinogen III)
uroporphyrinogen methyltransferase uroporphyrinogen-III synthase valine transaminase xylose isomerase
ammonia transport via diffusion (extracellular to periplasm) ATP synthase (four protons for one ATP) (periplasm) calcium (Ca+2) transport via diffusion (extracellular to periplasm) chloride (Cl-1) transport via diffusion (extracellular to periplasm)
CO2 transport via diffusion (extracellular to periplasm) cobalt (Co+2) transport via diffusion (extracellular to periplasm) copper (Cu+2) transport via diffusion (extracellular to periplasm) cytochrome oxidase bd (menaquinol-8: 2 protons) (periplasm)
cytochrome oxidase bd (ubiquinol-8: 2 protons) (periplasm) D-glucose transport via diffusion (extracellular to periplasm) irreversible D-glucose transport via PEP:Pyr PTS (periplasm) Fructose transport via PEP:Pyr PTS (f6p generating) (periplasm)
iron (II) transport via diffusion (extracellular to periplasm) iron (III) transport via diffusion (extracellular to periplasm) magnesium (Mg+2) transport via diffusion (extracellular to periplasm) Manganese (Mn+2) transport via diffusion (extracellular to periplasm)
Methanol transport via diffusion (extracellular to periplasm) molybdate transport via diffusion (extracellular to periplasm) murein polymerizing transglycosylase NAD(P) transhydrogenase (periplasm)
nickel transport via diffusion (extracellular to periplasm) oxygen transport via diffusion (extracellular to periplasm) phosphate transport via diffusion (extracellular to periplasm) potassium transport via diffusion (extracellular to periplasm)
sulfate transport via diffusion (extracellular to periplasm) zinc (Zn+2) transport via diffusion (extracellular to periplasm) 2-Octaprenylphenol hydroxylase (anaerobic) Dihydroneopterin monophosphate dephosphorylase
pyridoxine 5'-phosphate oxidase (anaerboic pyrimidine phosphatase Sink needed to allow (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran to leave system Sink needed to allow 5'-deoxyribose to leave system
Sink needed to allow p-Cresol to leave system Sink needed to allow S-Adenosyl-4-methylthio-2-oxobutanoate to leave system growth  
Physical entities
Compartments Species
cell (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one (R)-2,3-Dihydroxy-3-methylbutanoate
(R)-2,3-Dihydroxy-3-methylpentanoate (R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] (R)-Glycerate
(R)-Pantoate (R)-Pantothenate (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
(S)-2-Aceto-2-hydroxybutanoate (S)-2-Acetolactate (S)-3-Hydroxybutanoyl-CoA
(S)-3-Hydroxydecanoyl-CoA (S)-3-Hydroxydodecanoyl-CoA (S)-3-Hydroxyhexadecanoyl-CoA
(S)-3-Hydroxyhexanoyl-CoA (S)-3-Hydroxyoctanoyl-CoA (S)-3-Hydroxytetradecanoyl-CoA
(S)-3-Methyl-2-oxopentanoate (S)-Dihydroorotate 1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate
1,2-dihexadecanoyl-sn-glycerol 3-phosphate 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate 1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide
1-(5-Phosphoribosyl)-AMP 1-(5-Phosphoribosyl)-ATP 1-deoxy-D-xylulose 5-phosphate
1-hexadec-9-enoyl-sn-glycerol 3-phosphate 1-hexadecanoyl-sn-glycerol 3-phosphate 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
1-Pyrroline-5-carboxylate 10-Formyltetrahydrofolate 2,3,2'3'-Tetrakis(beta-hydroxymyristoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
2,3,4,5-Tetrahydrodipicolinate 2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate 2,3-Dihydrodipicolinate
2,5-Diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
2-C-methyl-D-erythritol 2,4-cyclodiphosphate 2-C-methyl-D-erythritol 4-phosphate 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
2-Dehydro-3-deoxy-D-gluconate 6-phosphate 2-Dehydropantoate 2-Hydroxy-3-oxopropanoate
2-Isopropylmaleate 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate 2-Octaprenyl-6-hydroxyphenol
2-Octaprenylphenol 2-Oxo-3-hydroxy-4-phosphobutanoate 2-Oxobutanoate
2-Oxoglutarate 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 3'-Phosphoadenylyl sulfate
3,4-dihydroxy-2-butanone 4-phosphate 3-(4-Hydroxyphenyl)pyruvate 3-(Imidazol-4-yl)-2-oxopropyl phosphate
3-Carboxy-2-hydroxy-4-methylpentanoate 3-Carboxy-3-hydroxy-4-methylpentanoate 3-Carboxy-4-methyl-2-oxopentanoate
3-Dehydroquinate 3-Dehydroshikimate 3-Deoxy-D-manno-2-octulosonate
3-Deoxy-D-manno-octulosonate 8-phosphate 3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester 3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester
3-Methyl-2-oxobutanoate 3-Octaprenyl-4-hydroxybenzoate 3-Oxo-glutaryl-[acyl-carrier protein] methyl ester
3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester 3-Oxodecanoyl-CoA 3-Oxododecanoyl-CoA
3-Oxohexadecanoyl-CoA 3-Oxohexanoyl-CoA 3-Oxooctanoyl-CoA
3-Oxotetradecanoyl-[acyl-carrier protein] 3-Oxotetradecanoyl-CoA 3-Phospho-D-glycerate
3-Phospho-D-glyceroyl phosphate 3-Phosphohydroxypyruvate 4,5-dihydroxy-2,3-pentanedione
4-(1-D-Ribitylamino)-5-aminouracil 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 4-Amino-2-methyl-5-phosphomethylpyrimidine
4-amino-4-deoxychorismate 4-Aminobenzoate 4-Hydroxybenzoate
4-Methyl-2-oxopentanoate 4-Methyl-5-(2-phosphoethyl)-thiazole 4-Phospho-D-erythronate
4-Phospho-L-aspartate 5'-Deoxyadenosine 5'-deoxyribose
5,10-Methenyltetrahydrofolate 5,10-Methylenetetrahydrofolate 5,6,7,8-Tetrahydrofolate
5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide 5-amino-1-(5-phospho-D-ribosyl)imidazole 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate 5-Amino-4-oxopentanoate 5-Amino-6-(5'-phosphoribitylamino)uracil
5-Amino-6-(5'-phosphoribosylamino)uracil 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 5-Methyltetrahydrofolate
5-O-(1-Carboxyvinyl)-3-phosphoshikimate 5-Phospho-alpha-D-ribose 1-diphosphate 5-Phospho-beta-D-ribosylamine
5-phosphoribosyl-5-carboxyaminoimidazole 6,7-Dimethyl-8-(1-D-ribityl)lumazine 6-hydroxymethyl dihydropterin
6-hydroxymethyl-dihydropterin pyrophosphate 6-Phospho-D-gluconate 6-phospho-D-glucono-1,5-lactone
7,8-Diaminononanoate 7,8-Dihydrofolate 8-Amino-7-oxononanoate
[2Fe-1S] desulfurated iron-sulfur cluster [2Fe-2S] iron-sulfur cluster [4Fe-4S] iron-sulfur cluster
Acetaldehyde Acetate Acetoacetyl-CoA
Acetyl phosphate Acetyl-CoA acyl carrier protein
Adenine Adenosine Adenosine 3',5'-bisphosphate
Adenosine 5'-phosphosulfate adenylated molybdopterin ADP
all-trans-Octaprenyl diphosphate alpha-D-Ribose 1-phosphate alpha-D-Ribose 5-phosphate
Ammonium AMP Anthranilate
ATP beta-Alanine Bicarbonate
Biotin bis-molybdenum cofactor bis-molybdopterin guanine dinucleotide
bis-molybdopterin mono-guanine dinucleotide Butanoyl-CoA C'-(3-Indolyl)-glycerol 3-phosphate
Calcium Carbamoyl phosphate CDP
CDP-1,2-dihexadec-9-enoylglycerol CDP-1,2-dihexadecanoylglycerol Chloride
chorismate cis-Aconitate cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)
Citrate CMP CMP-3-deoxy-D-manno-octulosonate
CO2 Co2+ Coenzyme A
Coproporphyrinogen III Crotonoyl-CoA CTP
Cu2+ cyclic pyranopterin monophosphate D-4'-Phosphopantothenate
D-Alanine D-Alanyl-D-alanine D-Arabinose 5-phosphate
D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate D-Erythrose 4-phosphate D-Fructose
D-Fructose 6-phosphate D-Glucosamine 1-phosphate D-Glucosamine 6-phosphate
D-Glucose D-Glucose 6-phosphate D-Glutamate
D-Glycerate 2-phosphate D-Ribulose 5-phosphate D-Xylulose 5-phosphate
dATP dCTP Deamino-NAD+
Decanoyl-CoA (n-C10:0CoA) dehydroglycine Dephospho-CoA
Dethiobiotin dGTP Dihydroneopterin
Dihydroneopterin monophosphate Dihydropteroate dihydrosirohydrochlorin
Dihydroxyacetone phosphate Dimethylallyl diphosphate Diphosphate
Dodecanoate (n-C12:0) Dodecanoyl-ACP (n-C12:0ACP) Dodecanoyl-CoA (n-C12:0CoA)
dUMP dUTP Enoylglutaryl-[acyl-carrier protein] methyl ester
Enoylpimeloyl-[acyl-carrier protein] methyl ester Farnesyl diphosphate Fe2+
Fe3+ Flavin adenine dinucleotide oxidized Flavin adenine dinucleotide reduced
Flavodoxin reduced flavodoxin semi oxidized FMN
Formate Fumarate GDP
Geranyl diphosphate Glutaryl-[acyl-carrier protein] methyl ester Glyceraldehyde 3-phosphate
Glycerol 3-phosphate Glycine Glycolaldehyde
Glycolate Glyoxylate GMP
GTP Hexadecanoate (n-C16:0) Hexadecenoate (n-C16:1)
Hexadecenoyl-CoA (n-C16:1CoA) Hexanoyl-CoA (n-C6:0CoA) Hydrogen peroxide
Hydrogen sulfide Hydroxymethylbilane Iminoaspartate
IMP Indole IscS sulfur acceptor protein
IscS with bound sulfur IscU scaffold protein IscU with bound [2Fe-2S] cluster
IscU with bound [4Fe-4S] cluster IscU with two bound [2Fe-2S] clusters Isocitrate
Isopentenyl diphosphate KDO(2)-lipid IV(A) KDO-lipid IV(A)
L-2-Amino-3-oxobutanoate L-Alanine L-Arginine
L-Asparagine L-Aspartate L-Aspartate 4-semialdehyde
L-Citrulline L-Cystathionine L-Cysteine
L-Glutamate L-Glutamate 1-semialdehyde L-Glutamate 5-phosphate
L-Glutamate 5-semialdehyde L-Glutamine L-Glutamyl-tRNA(Glu)
L-Histidine L-Histidinol L-Histidinol phosphate
L-Homocysteine L-Homoserine L-Isoleucine
L-Leucine L-Lysine L-Malate
L-Methionine L-Phenylalanine L-Proline
L-Serine L-Threonine L-Tryptophan
L-Tyrosine L-Valine Lipid A Disaccharide
LL-2,6-Diaminoheptanedioate magnesium Malonyl-[acyl-carrier protein]
Malonyl-CoA malonyl-CoA methyl ester Menaquinol 8
Menaquinone 8 meso-2,6-Diaminoheptanedioate Methanol
Mn2+ MoaD Protein with bound AMP MoaD Protein with carboxylate
MoaD Protein with thiocarboxylate Molybdate molybdenum cofactor
molybdopterin N(omega)-(L-Arginino)succinate N-((R)-4-Phosphopantothenoyl)-L-cysteine
N-(5-Phospho-D-ribosyl)anthranilate N-Acetyl-D-glucosamine 1-phosphate N-Acetyl-L-glutamate
N-Acetyl-L-glutamate 5-semialdehyde N-Acetyl-L-glutamyl 5-phosphate N-Carbamoyl-L-aspartate
N-Succinyl-2-L-amino-6-oxoheptanedioate N-Succinyl-LL-2,6-diaminoheptanedioate N1-(5-Phospho-D-ribosyl)glycinamide
N2-Acetyl-L-ornithine N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide N6-(1,2-Dicarboxyethyl)-AMP
nickel Nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide - reduced
Nicotinamide adenine dinucleotide phosphate Nicotinamide adenine dinucleotide phosphate - reduced Nicotinate D-ribonucleotide
O-Acetyl-L-serine O-Phospho-4-hydroxy-L-threonine O-Phospho-L-homoserine
O-Phospho-L-serine O-Succinyl-L-homoserine O2
Octanoyl-CoA (n-C8:0CoA) Ornithine Orotate
Orotidine 5'-phosphate Oxaloacetate Oxidized thioredoxin
p-Cresol Palmitoyl-ACP (n-C16:0ACP) Palmitoyl-CoA (n-C16:0CoA)
Pantetheine 4'-phosphate Phenylpyruvate Phosphate
phosphatidylethanolamine (dihexadec-9enoyl, n-C16:1) phosphatidylethanolamine (dihexadecanoyl, n-C16:0) phosphatidylserine (dihexadec-9-enoyl, n-C16:1)
phosphatidylserine (dihexadecanoyl, n-C16:0) Phosphoenolpyruvate Pimeloyl-[acyl-carrier protein]
Pimeloyl-[acyl-carrier protein] methyl ester Porphobilinogen potassium
Prephenate Protoheme Protoporphyrin
Protoporphyrinogen IX Pyridoxal 5'-phosphate Pyridoxine 5'-phosphate
Pyruvate Quinolinate Reduced thioredoxin
Riboflavin S-Adenosyl-4-methylthio-2-oxobutanoate S-Adenosyl-L-homocysteine
S-Adenosyl-L-methionine S-Ribosyl-L-homocysteine Sedoheptulose 7-phosphate
Shikimate Shikimate 5-phosphate Siroheme
sirohydrochlorin Succinate Succinyl-CoA
Sulfate Sulfite Tetradecanoyl-CoA (n-C14:0CoA)
Thiamin monophosphate Thiamine diphosphate trans-Dec-2-enoyl-CoA
trans-Dodec-2-enoyl-CoA trans-Hex-2-enoyl-CoA trans-Hexadec-2-enoyl-CoA
trans-Oct-2-enoyl-CoA trans-Tetradec-2-enoyl-CoA tRNA (Glu)
two disacharide linked murein units, pentapeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain) two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain) Ubiquinol-8
Ubiquinone-8 UDP UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine
UDP-N-acetyl-D-glucosamine UDP-N-acetylmuramate UDP-N-acetylmuramoyl-L-alanine
UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate UDP-N-acetylmuramoyl-L-alanyl-D-glutamate UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
UMP Undecaprenyl diphosphate Undecaprenyl phosphate
Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-ala-D-glu-meso-2,6-diaminopimeloyl-D-ala-D-ala Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine Uroporphyrinogen III
UTP Xanthosine 5'-phosphate Zinc
thrA thrB thrC
talB mog ribF
ispH dapB folA
pdxA leuD leuC
leuB leuA ilvI
ilvH ftsI murE
murF mraY murD
murG murC ddlB
lpxC mutT coaE
nadC aceE aceF
lpdA acnB can
panD panC panB
folK mrcB hemL
mtnN dapD pyrH
dxr uppS cdsA
lpxD fabZ lpxA
lpxB accA fadE
proB proA argF
yahI cynT mhpF
hemB ddlA proC
aroL mak ribD
ribH thiL dxs
ispA thiI panE
tesB adk hemH
gcl glxR arcC
purK purE lpxH
folD mrdA nadD
hscC fldA gltA
sucC sucD nadA
aroG gpmA pgl
bioA bioB bioF
bioC bioD1 moaA
moaC moaD moaE
moeB moeA ybjG
ltaE trxB pflA
pflB serC aroA
cmk lpxK kdsB
aspC pyrD pyrC
fabH fabD fabG
acpP fabF pabC
tmk purB icd
dadX prs ispE
hemA kdsA adhE
trpA trpB trpC
trpD trpE acnA
ribA pgpB pyrF
fabI puuA ydbK
aldA folM fumC
fumA malY ribE
ydiB aroD aroH
nadE astC gdhA
gapA pabB purT
eda edd zwf
nudB hisG hisD
hisC hisB hisH
hisA hisF hisI
thiD folE atoB
nudI yfbQ ackA
pta ubiX purF
folC accD pdxB
fabB aroC fadJ
fadI yfdZ glk
gltX cysK cysM
hemF eutD talA
tktB dapE purC
dapA purM ppk
guaA guaB ispG
ndk iscA nifU
iscS glyA purL
pdxJ nadB grcA
trxC pssA pheA
tyrA aroF ppnK
luxS gutQ ispF
ispD cysC cysN
cysD cysH cysI
cysJ eno pyrG
argA thyA aas
lysA yqeA fldB
serA rpiA pgk
epd tktA metK
glcD metC plsC
ribB uppP folB
tdcE tdcD tdcB
garK garR argG
glmM folP ispB
murA kdsD kdsC
mdh accB accC
aroE argD pabA
cysG yhfW rpe
aroB aroK mrcA
bioH asd xylA
cysE gpsA gpmI
tdh kbl waaA
coaD coaBC dut
pyrE gmk ilvN
ilvB tnaA glmS
glmU asnA ilvE
ilvD ilvA ilvC
trxA hemX hemD
hemC cyaY dapF
metE ubiD fre
fadA fadB hemG
mobB mobA glnA
tpiA fpr metB
metL metF pflD
pflC ppc argE
argC argB argH
murI murB coaA
thiH thiG thiF
thiE thiC hemE
purD purH metA
metH lysC pgi
ubiC ubiA plsB
alr tyrB aphA
rpiB fumB psd
rsgA purA cysQ
nrdG nrdD pyrI
pyrB argI sgcE
deoB deoD serB
gpmB thiS glcF
extracellular Ammonium Calcium Chloride
CO2 Co2+ Cu2+
D-Glucose Fe2+ Fe3+
magnesium Methanol Mn2+
Molybdate nickel O2
Phosphate potassium Sulfate
Zinc (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran 5'-deoxyribose
p-Cresol S-Adenosyl-4-methylthio-2-oxobutanoate  
Global parameters
zero_flux ic0003 ic0004 ic0017
ic0018 ic0028 ic0029 ic0032
ic0033 ic0040 ic0041 ic0042
ic0043 ic0044 ic0045 ic0046
ic0047 ic0049 ic0050 ic0051
ic0052 ic0073 ic0075 ic0096
ic0097 ic0098 ic0099 ic0116
ic0119 ic0121 ic0123 ic0128
ic0133 ic0147 ic0148 ic0149
ic0155 ic0160 ic0162 ic0191
ic0193 ic0194 ic0195 ic0201
ic0203 ic0214 ic0217 ic0218
ic0226 ic0229 ic0231 ic0232
ic0233 ic0237 ic0252 ic0255
ic0262 ic0263 ic0265 ic0266
ic0267 ic0269 ic0270 ic0271
ic0272 ic0276 ic0277 ic0282
ic0283 ic0289 ic0290 ic0293
ic0295 ic0297 ic0299 ic0303
ic0304 ic0305 ic0306 ic0307
ic0308 ic0310 ic0311 ic0312
ic0313 ic0316 ic0318 ic0325
ic0328 ic0330 ic0331 ic0332
ic0333 ic0334 ic0335 ic0336
ic0337 ic0341 ic0342 ic0343
ic0344 ic0345 ic0346 ic0347
ic0352 ic0354 ic0359 ic0360
ic0361 ic0362 ic0364 ic0367
ic0368 ic0369 ic0370 ic0371
ic0372 ic0376 ic0377 ic0378
ic0380 ic0381 ic0384 ic0391
ic0393 ic0395 ic0397 ic0405
ic0408 ic0411 ic0412 ic0420
ic0421 ic0435 ic0445 ic0446
ic0451 ic0453 ic0454 ic0457
ic0467 ic0470 ic0474 ic0476
ic0479 ic0480 ic0481 ic0488
ic0493 ic0497 ic0499 ic0502
ic0510 ic0512 ic0513 ic0520
ic0522 ic0526 ic0530 ic0533
ic0536 ic0539 ic0542 ic0543
ic0546 ic0548 ic0555 ic0565
ic0574 ic0575 ic0579 ic0581
ic0585 ic0599 ic0600 ic0603
ic0611 ic0620 ic0621 ic0622
ic0627 ic0653 ic0654 ic0657
ic0659 ic0663 ic0671 ic0675
ic0704 ic0721 ic0726 ic0731
ic0732 ic0737 ic0738 ic0754
ic0755 ic0760 ic0765 ic0766
ic0767 ic0768 ic0772 ic0779
ic0783 ic0785 ic0789 ic0790
ic0795 ic0802 ic0805 ic0807
ic0810 ic0812 ic0813 ic0826
ic0838 ic0840 ic0841 ic0843
ic0859 ic0860 ic0861 ic0862
ic0863 ic0867 ic0875 ic0896
ic0903 ic0910 ic0913 ic0920
ic0929 ic0936 ic0937 ic0941
ic0942 ic0945 ic0971 ic0976
ic0979 ic0984 ic0991 ic0994
ic0998 ic1005 ic1006 ic1009
ic1017 ic1018 ic1019 ic1020
ic1021 ic1022 ic1027 ic1028
ic1033 ic1038 ic1040 ic1041
ic1061 ic1068 ic1072 ic1075
ic1081 ic1082 ic1083 ic1095
ic1098 ic1099 ic1100 ic1101
ic1105 ic1106 ic1109 ic1110
ic1112 ic1113 ic1119 ic1127
ic1131 ic1138 ic1141 ic1151
ic1155 ic1170 ic1179 ic1185
ic1189 ic1193 ic1204 ic1211
ic1212 ic1214 ic1216 ic1217
ic1218 ic1239 ic1240 ic1242
ic1248 ic1255 ic1257 ic1258
ic1259 ic1260 ic1261 ic1263
ic1264 ic1265 ic1274 ic1277
ic1278 ic1287 ic1302 ic1303
ic1304 ic1312 ic1315 ic1316
ic1318 ic1321 ic1322 ic1327
ic1329 ic1331 ic1333 ic1334
ic1335 ic1336 ic1340 ic1358
ic1362 ic1363 ic1364 ic1367
ic1372 ic1374 ic1390 ic1391
ic1394 ic1397 ic1399 ic1406
ic1407 ic1411 ic1412 ic1413
ic1429 ic1430 ic1432 ic1435
ic1437 ic1476 ic1477 ic1484
ic1491 ic1492 ic1493 ic1494
ic1496 ic1497 ic1508 ic1511
ic1512 ic1522 ic1530 ic1531
ic1537 ic1544 ic1546 ic1550
ic1551 ic1552 ic1558 ic1561
ic1571 ic1574 ic1577 ic1578
ic1595 ic1599 ic1609 ic1611
ic1612 ic1632 ic1643 ic1644
ic1668 ic1670 ic1672 ic1674
ic1676 ic1680 ic1690 ic1719
ic1725 ic1731 ic1732 ic1733
ic1734 ic1735 ic1736 ic1742
ic1745 ic1750 ic1751 ic1752
ic1754 ic1755 ic1762 ic1765
ic1768 ic1776 ic1777 ic1791
ic1792 ic1799 ic1804 ic1806
Reactions (399)
 (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous) [(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one] ↔ [(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran];   {(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one} , {(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran}
 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase [1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide] ↔ [5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide];   {hisA} , {1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide} , {5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide}
 1-deoxy-D-xylulose 5-phosphate synthase [Glyceraldehyde 3-phosphate] + [Pyruvate] ↔ [CO2] + [1-deoxy-D-xylulose 5-phosphate];   {dxs} , {Glyceraldehyde 3-phosphate} , {Pyruvate} , {CO2} , {1-deoxy-D-xylulose 5-phosphate}
 1-deoxy-D-xylulose reductoisomerase [1-deoxy-D-xylulose 5-phosphate] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [2-C-methyl-D-erythritol 4-phosphate] + [Nicotinamide adenine dinucleotide phosphate];   {dxr} , {1-deoxy-D-xylulose 5-phosphate} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {2-C-methyl-D-erythritol 4-phosphate} , {Nicotinamide adenine dinucleotide phosphate}
 1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1) [1-hexadec-9-enoyl-sn-glycerol 3-phosphate] + [cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)] ↔ [acyl carrier protein] + [1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate];   {plsC} , {1-hexadec-9-enoyl-sn-glycerol 3-phosphate} , {cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)} , {acyl carrier protein} , {1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate}
 1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0) [1-hexadecanoyl-sn-glycerol 3-phosphate] + [Palmitoyl-ACP (n-C16:0ACP)] ↔ [acyl carrier protein] + [1,2-dihexadecanoyl-sn-glycerol 3-phosphate];   {plsC} , {1-hexadecanoyl-sn-glycerol 3-phosphate} , {Palmitoyl-ACP (n-C16:0ACP)} , {acyl carrier protein} , {1,2-dihexadecanoyl-sn-glycerol 3-phosphate}
 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp) [1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate] + [Nicotinamide adenine dinucleotide - reduced] ↔ [Dimethylallyl diphosphate] + [Nicotinamide adenine dinucleotide];   {ispH} , {1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate} , {Nicotinamide adenine dinucleotide - reduced} , {Dimethylallyl diphosphate} , {Nicotinamide adenine dinucleotide}
 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp) [1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate] + [Nicotinamide adenine dinucleotide - reduced] ↔ [Isopentenyl diphosphate] + [Nicotinamide adenine dinucleotide];   {ispH} , {1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate} , {Nicotinamide adenine dinucleotide - reduced} , {Isopentenyl diphosphate} , {Nicotinamide adenine dinucleotide}
 2-aceto-2-hydroxybutanoate synthase [2-Oxobutanoate] + [Pyruvate] ↔ [(S)-2-Aceto-2-hydroxybutanoate] + [CO2];   {ilvB} , {ilvI} , {ilvH} , {ilvN} , {2-Oxobutanoate} , {Pyruvate} , {(S)-2-Aceto-2-hydroxybutanoate} , {CO2}
 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol] ↔ [2-C-methyl-D-erythritol 2,4-cyclodiphosphate] + [CMP];   {ispF} , {2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol} , {2-C-methyl-D-erythritol 2,4-cyclodiphosphate} , {CMP}
 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [2-C-methyl-D-erythritol 4-phosphate] + [CTP] ↔ [4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol] + [Diphosphate];   {ispD} , {2-C-methyl-D-erythritol 4-phosphate} , {CTP} , {4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol} , {Diphosphate}
 2-dehydro-3-deoxy-phosphogluconate aldolase [2-Dehydro-3-deoxy-D-gluconate 6-phosphate] ↔ [Glyceraldehyde 3-phosphate] + [Pyruvate];   {eda} , {2-Dehydro-3-deoxy-D-gluconate 6-phosphate} , {Glyceraldehyde 3-phosphate} , {Pyruvate}
 2-dehydropantoate 2-reductase [2-Dehydropantoate] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [Nicotinamide adenine dinucleotide phosphate] + [(R)-Pantoate];   {panE} , {ilvC} , {2-Dehydropantoate} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {Nicotinamide adenine dinucleotide phosphate} , {(R)-Pantoate}
 2-isopropylmalate hydratase [3-Carboxy-3-hydroxy-4-methylpentanoate] ↔ [2-Isopropylmaleate];   {leuC} , {leuD} , {3-Carboxy-3-hydroxy-4-methylpentanoate} , {2-Isopropylmaleate}
 2-isopropylmalate synthase [3-Methyl-2-oxobutanoate] + [Acetyl-CoA] ↔ [3-Carboxy-3-hydroxy-4-methylpentanoate] + [Coenzyme A];   {leuA} , {3-Methyl-2-oxobutanoate} , {Acetyl-CoA} , {3-Carboxy-3-hydroxy-4-methylpentanoate} , {Coenzyme A}
 2-Oxo-4-methyl-3-carboxypentanoate decarboxylation [3-Carboxy-4-methyl-2-oxopentanoate] ↔ [4-Methyl-2-oxopentanoate] + [CO2];   {3-Carboxy-4-methyl-2-oxopentanoate} , {4-Methyl-2-oxopentanoate} , {CO2}
 2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase [2-C-methyl-D-erythritol 2,4-cyclodiphosphate] + 2.0 × [Flavodoxin reduced] ↔ 2.0 × [flavodoxin semi oxidized] + [1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate];   {fldA} , {ispG} , {fldB} , {2-C-methyl-D-erythritol 2,4-cyclodiphosphate} , {Flavodoxin reduced} , {flavodoxin semi oxidized} , {1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate}
 3',5'-bisphosphate nucleotidase [Adenosine 3',5'-bisphosphate] ↔ [AMP] + [Phosphate];   {cysQ} , {Adenosine 3',5'-bisphosphate} , {AMP} , {Phosphate}
 3,4-Dihydroxy-2-butanone-4-phosphate synthase [D-Ribulose 5-phosphate] ↔ [3,4-dihydroxy-2-butanone 4-phosphate] + [Formate];   {ribB} , {D-Ribulose 5-phosphate} , {3,4-dihydroxy-2-butanone 4-phosphate} , {Formate}
 3-cis-2-trans-enoyl-CoA isomerase [trans-Hexadec-2-enoyl-CoA] ↔ [Hexadecenoyl-CoA (n-C16:1CoA)];   {fadB} , {trans-Hexadec-2-enoyl-CoA} , {Hexadecenoyl-CoA (n-C16:1CoA)}
 3-dehydroquinate dehydratase, irreversible [3-Dehydroquinate] ↔ [3-Dehydroshikimate];   {aroD} , {3-Dehydroquinate} , {3-Dehydroshikimate}
 3-dehydroquinate synthase [2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate] ↔ [3-Dehydroquinate] + [Phosphate];   {aroB} , {2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate} , {3-Dehydroquinate} , {Phosphate}
 3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase [D-Arabinose 5-phosphate] + [Phosphoenolpyruvate] ↔ [3-Deoxy-D-manno-octulosonate 8-phosphate] + [Phosphate];   {kdsA} , {D-Arabinose 5-phosphate} , {Phosphoenolpyruvate} , {3-Deoxy-D-manno-octulosonate 8-phosphate} , {Phosphate}
 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase [D-Erythrose 4-phosphate] + [Phosphoenolpyruvate] ↔ [2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate] + [Phosphate];   {aroH} , {aroF} , {aroG} , {D-Erythrose 4-phosphate} , {Phosphoenolpyruvate} , {2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate} , {Phosphate}
 3-deoxy-D-manno-octulosonic acid transferase [CMP-3-deoxy-D-manno-octulosonate] + [2,3,2'3'-Tetrakis(beta-hydroxymyristoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate] ↔ [CMP] + [KDO-lipid IV(A)];   {waaA} , {CMP-3-deoxy-D-manno-octulosonate} , {2,3,2'3'-Tetrakis(beta-hydroxymyristoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate} , {CMP} , {KDO-lipid IV(A)}
 3-deoxy-D-manno-octulosonic acid transferase [CMP-3-deoxy-D-manno-octulosonate] + [KDO-lipid IV(A)] ↔ [CMP] + [KDO(2)-lipid IV(A)];   {waaA} , {CMP-3-deoxy-D-manno-octulosonate} , {KDO-lipid IV(A)} , {CMP} , {KDO(2)-lipid IV(A)}
 3-deoxy-manno-octulosonate cytidylyltransferase [CTP] + [3-Deoxy-D-manno-2-octulosonate] ↔ [CMP-3-deoxy-D-manno-octulosonate] + [Diphosphate];   {kdsB} , {CTP} , {3-Deoxy-D-manno-2-octulosonate} , {CMP-3-deoxy-D-manno-octulosonate} , {Diphosphate}
 3-deoxy-manno-octulosonate-8-phosphatase [3-Deoxy-D-manno-octulosonate 8-phosphate] ↔ [3-Deoxy-D-manno-2-octulosonate] + [Phosphate];   {kdsC} , {3-Deoxy-D-manno-octulosonate 8-phosphate} , {3-Deoxy-D-manno-2-octulosonate} , {Phosphate}
 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) [(S)-3-Hydroxybutanoyl-CoA] ↔ [Crotonoyl-CoA];   {fadB} , {fadJ} , {(S)-3-Hydroxybutanoyl-CoA} , {Crotonoyl-CoA}
 3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA) [(S)-3-Hydroxydecanoyl-CoA] ↔ [trans-Dec-2-enoyl-CoA];   {fadB} , {fadJ} , {(S)-3-Hydroxydecanoyl-CoA} , {trans-Dec-2-enoyl-CoA}
 3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA) [(S)-3-Hydroxydodecanoyl-CoA] ↔ [trans-Dodec-2-enoyl-CoA];   {fadB} , {fadJ} , {(S)-3-Hydroxydodecanoyl-CoA} , {trans-Dodec-2-enoyl-CoA}
 3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA) [(S)-3-Hydroxyhexadecanoyl-CoA] ↔ [trans-Hexadec-2-enoyl-CoA];   {fadB} , {fadJ} , {(S)-3-Hydroxyhexadecanoyl-CoA} , {trans-Hexadec-2-enoyl-CoA}
 3-hydroxyacyl-CoA dehydratase (3-hydroxyhexanoyl-CoA) [(S)-3-Hydroxyhexanoyl-CoA] ↔ [trans-Hex-2-enoyl-CoA];   {fadB} , {fadJ} , {(S)-3-Hydroxyhexanoyl-CoA} , {trans-Hex-2-enoyl-CoA}
 3-hydroxyacyl-CoA dehydratase (3-hydroxyoctanoyl-CoA) [(S)-3-Hydroxyoctanoyl-CoA] ↔ [trans-Oct-2-enoyl-CoA];   {fadB} , {fadJ} , {(S)-3-Hydroxyoctanoyl-CoA} , {trans-Oct-2-enoyl-CoA}
 3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA) [(S)-3-Hydroxytetradecanoyl-CoA] ↔ [trans-Tetradec-2-enoyl-CoA];   {fadB} , {fadJ} , {(S)-3-Hydroxytetradecanoyl-CoA} , {trans-Tetradec-2-enoyl-CoA}
 3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA) [3-Oxodecanoyl-CoA] + [Nicotinamide adenine dinucleotide - reduced] ↔ [(S)-3-Hydroxydecanoyl-CoA] + [Nicotinamide adenine dinucleotide];   {fadB} , {fadJ} , {3-Oxodecanoyl-CoA} , {Nicotinamide adenine dinucleotide - reduced} , {(S)-3-Hydroxydecanoyl-CoA} , {Nicotinamide adenine dinucleotide}
 3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA) [3-Oxododecanoyl-CoA] + [Nicotinamide adenine dinucleotide - reduced] ↔ [(S)-3-Hydroxydodecanoyl-CoA] + [Nicotinamide adenine dinucleotide];   {fadB} , {fadJ} , {3-Oxododecanoyl-CoA} , {Nicotinamide adenine dinucleotide - reduced} , {(S)-3-Hydroxydodecanoyl-CoA} , {Nicotinamide adenine dinucleotide}
 3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA) [3-Oxohexadecanoyl-CoA] + [Nicotinamide adenine dinucleotide - reduced] ↔ [(S)-3-Hydroxyhexadecanoyl-CoA] + [Nicotinamide adenine dinucleotide];   {fadB} , {fadJ} , {3-Oxohexadecanoyl-CoA} , {Nicotinamide adenine dinucleotide - reduced} , {(S)-3-Hydroxyhexadecanoyl-CoA} , {Nicotinamide adenine dinucleotide}
 3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA) [3-Oxohexanoyl-CoA] + [Nicotinamide adenine dinucleotide - reduced] ↔ [(S)-3-Hydroxyhexanoyl-CoA] + [Nicotinamide adenine dinucleotide];   {fadB} , {fadJ} , {3-Oxohexanoyl-CoA} , {Nicotinamide adenine dinucleotide - reduced} , {(S)-3-Hydroxyhexanoyl-CoA} , {Nicotinamide adenine dinucleotide}
 3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA) [3-Oxooctanoyl-CoA] + [Nicotinamide adenine dinucleotide - reduced] ↔ [(S)-3-Hydroxyoctanoyl-CoA] + [Nicotinamide adenine dinucleotide];   {fadB} , {fadJ} , {3-Oxooctanoyl-CoA} , {Nicotinamide adenine dinucleotide - reduced} , {(S)-3-Hydroxyoctanoyl-CoA} , {Nicotinamide adenine dinucleotide}
 3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA) [3-Oxotetradecanoyl-CoA] + [Nicotinamide adenine dinucleotide - reduced] ↔ [(S)-3-Hydroxytetradecanoyl-CoA] + [Nicotinamide adenine dinucleotide];   {fadB} , {fadJ} , {3-Oxotetradecanoyl-CoA} , {Nicotinamide adenine dinucleotide - reduced} , {(S)-3-Hydroxytetradecanoyl-CoA} , {Nicotinamide adenine dinucleotide}
 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) [Acetoacetyl-CoA] + [Nicotinamide adenine dinucleotide - reduced] ↔ [(S)-3-Hydroxybutanoyl-CoA] + [Nicotinamide adenine dinucleotide];   {fadB} , {fadJ} , {Acetoacetyl-CoA} , {Nicotinamide adenine dinucleotide - reduced} , {(S)-3-Hydroxybutanoyl-CoA} , {Nicotinamide adenine dinucleotide}
 3-isopropylmalate dehydratase [2-Isopropylmaleate] ↔ [3-Carboxy-2-hydroxy-4-methylpentanoate];   {leuC} , {leuD} , {2-Isopropylmaleate} , {3-Carboxy-2-hydroxy-4-methylpentanoate}
 3-isopropylmalate dehydrogenase [3-Carboxy-2-hydroxy-4-methylpentanoate] + [Nicotinamide adenine dinucleotide] ↔ [3-Carboxy-4-methyl-2-oxopentanoate] + [Nicotinamide adenine dinucleotide - reduced];   {leuB} , {3-Carboxy-2-hydroxy-4-methylpentanoate} , {Nicotinamide adenine dinucleotide} , {3-Carboxy-4-methyl-2-oxopentanoate} , {Nicotinamide adenine dinucleotide - reduced}
 3-methyl-2-oxobutanoate hydroxymethyltransferase [3-Methyl-2-oxobutanoate] + [5,10-Methylenetetrahydrofolate] ↔ [2-Dehydropantoate] + [5,6,7,8-Tetrahydrofolate];   {panB} , {3-Methyl-2-oxobutanoate} , {5,10-Methylenetetrahydrofolate} , {2-Dehydropantoate} , {5,6,7,8-Tetrahydrofolate}
 3-Oxo-glutaryl-[ACP] methyl ester dehydratase [3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester] ↔ [Enoylglutaryl-[acyl-carrier protein] methyl ester];   {fabZ} , {3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester} , {Enoylglutaryl-[acyl-carrier protein] methyl ester}
 3-Oxo-glutaryl-[ACP] methyl ester reductase [Nicotinamide adenine dinucleotide phosphate - reduced] + [3-Oxo-glutaryl-[acyl-carrier protein] methyl ester] ↔ [3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester] + [Nicotinamide adenine dinucleotide phosphate];   {fabG} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {3-Oxo-glutaryl-[acyl-carrier protein] methyl ester} , {3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester} , {Nicotinamide adenine dinucleotide phosphate}
 3-Oxo-glutaryl-[ACP] methyl ester synthase [Malonyl-[acyl-carrier protein]] + [malonyl-CoA methyl ester] ↔ [CO2] + [Coenzyme A] + [3-Oxo-glutaryl-[acyl-carrier protein] methyl ester];   {fabH} , {Malonyl-[acyl-carrier protein]} , {malonyl-CoA methyl ester} , {CO2} , {Coenzyme A} , {3-Oxo-glutaryl-[acyl-carrier protein] methyl ester}
 3-Oxo-pimeloyl-[ACP] methyl ester dehydratase [3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester] ↔ [Enoylpimeloyl-[acyl-carrier protein] methyl ester];   {fabZ} , {3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester} , {Enoylpimeloyl-[acyl-carrier protein] methyl ester}
 3-Oxo-pimeloyl-[ACP] methyl ester reductase [Nicotinamide adenine dinucleotide phosphate - reduced] + [3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester] ↔ [3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester] + [Nicotinamide adenine dinucleotide phosphate];   {fabG} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester} , {3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester} , {Nicotinamide adenine dinucleotide phosphate}
 3-Oxo-pimeloyl-[ACP] methyl ester synthase [Glutaryl-[acyl-carrier protein] methyl ester] + [Malonyl-[acyl-carrier protein]] ↔ [acyl carrier protein] + [CO2] + [3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester];   {fabB} , {Glutaryl-[acyl-carrier protein] methyl ester} , {Malonyl-[acyl-carrier protein]} , {acyl carrier protein} , {CO2} , {3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester}
 3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:0) [3-Oxotetradecanoyl-[acyl-carrier protein]] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]] + [Nicotinamide adenine dinucleotide phosphate];   {fabG} , {3-Oxotetradecanoyl-[acyl-carrier protein]} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]} , {Nicotinamide adenine dinucleotide phosphate}
 3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0) [Dodecanoyl-ACP (n-C12:0ACP)] + [Malonyl-[acyl-carrier protein]] ↔ [3-Oxotetradecanoyl-[acyl-carrier protein]] + [acyl carrier protein] + [CO2];   {fabF} , {fabB} , {Dodecanoyl-ACP (n-C12:0ACP)} , {Malonyl-[acyl-carrier protein]} , {3-Oxotetradecanoyl-[acyl-carrier protein]} , {acyl carrier protein} , {CO2}
 3-phosphoshikimate 1-carboxyvinyltransferase [Phosphoenolpyruvate] + [Shikimate 5-phosphate] ↔ [5-O-(1-Carboxyvinyl)-3-phosphoshikimate] + [Phosphate];   {aroA} , {Phosphoenolpyruvate} , {Shikimate 5-phosphate} , {5-O-(1-Carboxyvinyl)-3-phosphoshikimate} , {Phosphate}
 4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous) [4,5-dihydroxy-2,3-pentanedione] ↔ [(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one];   {4,5-dihydroxy-2,3-pentanedione} , {(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one}
 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol] + [ATP] ↔ [2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol] + [ADP];   {ispE} , {4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol} , {ATP} , {2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol} , {ADP}
 4-amino-2-methyl-5-phosphomethylpyrimidine synthetase [5-amino-1-(5-phospho-D-ribosyl)imidazole] + [Nicotinamide adenine dinucleotide] ↔ [4-Amino-2-methyl-5-phosphomethylpyrimidine] + 2.0 × [Formate] + [Nicotinamide adenine dinucleotide - reduced];   {thiC} , {5-amino-1-(5-phospho-D-ribosyl)imidazole} , {Nicotinamide adenine dinucleotide} , {4-Amino-2-methyl-5-phosphomethylpyrimidine} , {Formate} , {Nicotinamide adenine dinucleotide - reduced}
 4-amino-4-deoxychorismate synthase [chorismate] + [L-Glutamine] ↔ [4-amino-4-deoxychorismate] + [L-Glutamate];   {pabA} , {pabB} , {chorismate} , {L-Glutamine} , {4-amino-4-deoxychorismate} , {L-Glutamate}
 4-aminobenzoate synthase [4-amino-4-deoxychorismate] ↔ [4-Aminobenzoate] + [Pyruvate];   {pabC} , {4-amino-4-deoxychorismate} , {4-Aminobenzoate} , {Pyruvate}
 5'-deoxyadenosine nuclosidase [5'-Deoxyadenosine] ↔ [5'-deoxyribose] + [Adenine];   {mtnN} , {5'-Deoxyadenosine} , {5'-deoxyribose} , {Adenine}
 5,10-methylenetetrahydrofolate reductase (NADH) [5,10-Methylenetetrahydrofolate] + [Nicotinamide adenine dinucleotide - reduced] ↔ [5-Methyltetrahydrofolate] + [Nicotinamide adenine dinucleotide];   {metF} , {5,10-Methylenetetrahydrofolate} , {Nicotinamide adenine dinucleotide - reduced} , {5-Methyltetrahydrofolate} , {Nicotinamide adenine dinucleotide}
 5-amino-6-(5-phosphoribosylamino)uracil reductase [5-Amino-6-(5'-phosphoribosylamino)uracil] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [5-Amino-6-(5'-phosphoribitylamino)uracil] + [Nicotinamide adenine dinucleotide phosphate];   {ribD} , {5-Amino-6-(5'-phosphoribosylamino)uracil} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {5-Amino-6-(5'-phosphoribitylamino)uracil} , {Nicotinamide adenine dinucleotide phosphate}
 6-hydroxymethyl-dihydropterin pyrophosphokinase [6-hydroxymethyl dihydropterin] + [ATP] ↔ [6-hydroxymethyl-dihydropterin pyrophosphate] + [AMP];   {folK} , {6-hydroxymethyl dihydropterin} , {ATP} , {6-hydroxymethyl-dihydropterin pyrophosphate} , {AMP}
 6-phosphogluconate dehydratase [6-Phospho-D-gluconate] ↔ [2-Dehydro-3-deoxy-D-gluconate 6-phosphate];   {edd} , {6-Phospho-D-gluconate} , {2-Dehydro-3-deoxy-D-gluconate 6-phosphate}
 6-phosphogluconolactonase [6-phospho-D-glucono-1,5-lactone] ↔ [6-Phospho-D-gluconate];   {pgl} , {6-phospho-D-glucono-1,5-lactone} , {6-Phospho-D-gluconate}
 8-amino-7-oxononanoate synthase [L-Alanine] + [Pimeloyl-[acyl-carrier protein]] ↔ [8-Amino-7-oxononanoate] + [acyl carrier protein] + [CO2];   {bioF} , {L-Alanine} , {Pimeloyl-[acyl-carrier protein]} , {8-Amino-7-oxononanoate} , {acyl carrier protein} , {CO2}
 acetaldehyde dehydrogenase (acetylating) [Acetaldehyde] + [Coenzyme A] + [Nicotinamide adenine dinucleotide] ↔ [Acetyl-CoA] + [Nicotinamide adenine dinucleotide - reduced];   {mhpF} , {adhE} , {Acetaldehyde} , {Coenzyme A} , {Nicotinamide adenine dinucleotide} , {Acetyl-CoA} , {Nicotinamide adenine dinucleotide - reduced}
 acetate kinase [Acetate] + [ATP] ↔ [Acetyl phosphate] + [ADP];   {tdcD} , {ackA} , {purT} , {Acetate} , {ATP} , {Acetyl phosphate} , {ADP}
 acetolactate synthase 2.0 × [Pyruvate] ↔ [(S)-2-Acetolactate] + [CO2];   {ilvB} , {ilvI} , {ilvH} , {ilvN} , {Pyruvate} , {(S)-2-Acetolactate} , {CO2}
 acetyl-CoA C-acetyltransferase 2.0 × [Acetyl-CoA] ↔ [Acetoacetyl-CoA] + [Coenzyme A];   {atoB} , {fadA} , {fadI} , {Acetyl-CoA} , {Acetoacetyl-CoA} , {Coenzyme A}
 acetyl-CoA C-acyltransferase (butanoyl-CoA) (r) [Acetyl-CoA] + [Butanoyl-CoA] ↔ [3-Oxohexanoyl-CoA] + [Coenzyme A];   {fadA} , {fadI} , {Acetyl-CoA} , {Butanoyl-CoA} , {3-Oxohexanoyl-CoA} , {Coenzyme A}
 acetyl-CoA C-acyltransferase (decanoyl-CoA) (r) [Acetyl-CoA] + [Decanoyl-CoA (n-C10:0CoA)] ↔ [3-Oxododecanoyl-CoA] + [Coenzyme A];   {fadA} , {fadI} , {Acetyl-CoA} , {Decanoyl-CoA (n-C10:0CoA)} , {3-Oxododecanoyl-CoA} , {Coenzyme A}
 acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r) [Acetyl-CoA] + [Dodecanoyl-CoA (n-C12:0CoA)] ↔ [3-Oxotetradecanoyl-CoA] + [Coenzyme A];   {fadA} , {fadI} , {Acetyl-CoA} , {Dodecanoyl-CoA (n-C12:0CoA)} , {3-Oxotetradecanoyl-CoA} , {Coenzyme A}
 acetyl-CoA C-acyltransferase (hexanoyl-CoA) (r) [Acetyl-CoA] + [Hexanoyl-CoA (n-C6:0CoA)] ↔ [3-Oxooctanoyl-CoA] + [Coenzyme A];   {fadA} , {fadI} , {Acetyl-CoA} , {Hexanoyl-CoA (n-C6:0CoA)} , {3-Oxooctanoyl-CoA} , {Coenzyme A}
 acetyl-CoA C-acyltransferase (octanoyl-CoA) (r) [Acetyl-CoA] + [Octanoyl-CoA (n-C8:0CoA)] ↔ [3-Oxodecanoyl-CoA] + [Coenzyme A];   {fadA} , {fadI} , {Acetyl-CoA} , {Octanoyl-CoA (n-C8:0CoA)} , {3-Oxodecanoyl-CoA} , {Coenzyme A}
 acetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r) [Acetyl-CoA] + [Tetradecanoyl-CoA (n-C14:0CoA)] ↔ [3-Oxohexadecanoyl-CoA] + [Coenzyme A];   {fadA} , {fadI} , {Acetyl-CoA} , {Tetradecanoyl-CoA (n-C14:0CoA)} , {3-Oxohexadecanoyl-CoA} , {Coenzyme A}
 acetyl-CoA carboxylase [Acetyl-CoA] + [ATP] + [Bicarbonate] ↔ [ADP] + [Malonyl-CoA] + [Phosphate];   {accA} , {accC} , {accB} , {accD} , {Acetyl-CoA} , {ATP} , {Bicarbonate} , {ADP} , {Malonyl-CoA} , {Phosphate}
 acetylglutamate kinase [N-Acetyl-L-glutamate] + [ATP] ↔ [N-Acetyl-L-glutamyl 5-phosphate] + [ADP];   {argB} , {N-Acetyl-L-glutamate} , {ATP} , {N-Acetyl-L-glutamyl 5-phosphate} , {ADP}
 acetylornithine deacetylase [N2-Acetyl-L-ornithine] ↔ [Acetate] + [Ornithine];   {argE} , {N2-Acetyl-L-ornithine} , {Acetate} , {Ornithine}
 acetylornithine transaminase [N-Acetyl-L-glutamate 5-semialdehyde] + [L-Glutamate] ↔ [N2-Acetyl-L-ornithine] + [2-Oxoglutarate];   {astC} , {argD} , {N-Acetyl-L-glutamate 5-semialdehyde} , {L-Glutamate} , {N2-Acetyl-L-ornithine} , {2-Oxoglutarate}
 aconitase (half-reaction A, Citrate hydro-lyase) [Citrate] ↔ [cis-Aconitate];   {acnA} , {acnB} , {Citrate} , {cis-Aconitate}
 aconitase (half-reaction B, Isocitrate hydro-lyase) [cis-Aconitate] ↔ [Isocitrate];   {acnA} , {acnB} , {cis-Aconitate} , {Isocitrate}
 acyl-[acyl-carrier-protein] synthetase (n-C12:0) [acyl carrier protein] + [ATP] + [Dodecanoate (n-C12:0)] ↔ [AMP] + [Dodecanoyl-ACP (n-C12:0ACP)] + [Diphosphate];   {acpP} , {aas} , {acyl carrier protein} , {ATP} , {Dodecanoate (n-C12:0)} , {AMP} , {Dodecanoyl-ACP (n-C12:0ACP)} , {Diphosphate}
 acyl-[acyl-carrier-protein] synthetase (n-C16:0) [acyl carrier protein] + [ATP] + [Hexadecanoate (n-C16:0)] ↔ [AMP] + [Palmitoyl-ACP (n-C16:0ACP)] + [Diphosphate];   {acpP} , {aas} , {acyl carrier protein} , {ATP} , {Hexadecanoate (n-C16:0)} , {AMP} , {Palmitoyl-ACP (n-C16:0ACP)} , {Diphosphate}
 acyl-[acyl-carrier-protein] synthetase (n-C16:1) [acyl carrier protein] + [ATP] + [Hexadecenoate (n-C16:1)] ↔ [AMP] + [cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)] + [Diphosphate];   {acpP} , {aas} , {acyl carrier protein} , {ATP} , {Hexadecenoate (n-C16:1)} , {AMP} , {cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)} , {Diphosphate}
 acyl-CoA dehydrogenase (butanoyl-CoA) [Crotonoyl-CoA] + [Flavin adenine dinucleotide reduced] ↔ [Butanoyl-CoA] + [Flavin adenine dinucleotide oxidized];   {fadE} , {Crotonoyl-CoA} , {Flavin adenine dinucleotide reduced} , {Butanoyl-CoA} , {Flavin adenine dinucleotide oxidized}
 acyl-CoA dehydrogenase (decanoyl-CoA) [trans-Dec-2-enoyl-CoA] + [Flavin adenine dinucleotide reduced] ↔ [Decanoyl-CoA (n-C10:0CoA)] + [Flavin adenine dinucleotide oxidized];   {fadE} , {trans-Dec-2-enoyl-CoA} , {Flavin adenine dinucleotide reduced} , {Decanoyl-CoA (n-C10:0CoA)} , {Flavin adenine dinucleotide oxidized}
 acyl-CoA dehydrogenase (dodecanoyl-CoA) [trans-Dodec-2-enoyl-CoA] + [Flavin adenine dinucleotide reduced] ↔ [Dodecanoyl-CoA (n-C12:0CoA)] + [Flavin adenine dinucleotide oxidized];   {fadE} , {trans-Dodec-2-enoyl-CoA} , {Flavin adenine dinucleotide reduced} , {Dodecanoyl-CoA (n-C12:0CoA)} , {Flavin adenine dinucleotide oxidized}
 acyl-CoA dehydrogenase (hexadecanoyl-CoA) [Flavin adenine dinucleotide reduced] + [trans-Hexadec-2-enoyl-CoA] ↔ [Flavin adenine dinucleotide oxidized] + [Palmitoyl-CoA (n-C16:0CoA)];   {fadE} , {Flavin adenine dinucleotide reduced} , {trans-Hexadec-2-enoyl-CoA} , {Flavin adenine dinucleotide oxidized} , {Palmitoyl-CoA (n-C16:0CoA)}
 acyl-CoA dehydrogenase (hexanoyl-CoA) [Flavin adenine dinucleotide reduced] + [trans-Hex-2-enoyl-CoA] ↔ [Flavin adenine dinucleotide oxidized] + [Hexanoyl-CoA (n-C6:0CoA)];   {fadE} , {Flavin adenine dinucleotide reduced} , {trans-Hex-2-enoyl-CoA} , {Flavin adenine dinucleotide oxidized} , {Hexanoyl-CoA (n-C6:0CoA)}
 acyl-CoA dehydrogenase (octanoyl-CoA) [Flavin adenine dinucleotide reduced] + [trans-Oct-2-enoyl-CoA] ↔ [Flavin adenine dinucleotide oxidized] + [Octanoyl-CoA (n-C8:0CoA)];   {fadE} , {Flavin adenine dinucleotide reduced} , {trans-Oct-2-enoyl-CoA} , {Flavin adenine dinucleotide oxidized} , {Octanoyl-CoA (n-C8:0CoA)}
 acyl-CoA dehydrogenase (tetradecanoyl-CoA) [Flavin adenine dinucleotide reduced] + [trans-Tetradec-2-enoyl-CoA] ↔ [Flavin adenine dinucleotide oxidized] + [Tetradecanoyl-CoA (n-C14:0CoA)];   {fadE} , {Flavin adenine dinucleotide reduced} , {trans-Tetradec-2-enoyl-CoA} , {Flavin adenine dinucleotide oxidized} , {Tetradecanoyl-CoA (n-C14:0CoA)}
 adenosine kinase [Adenosine] + [ATP] ↔ [ADP] + [AMP];   {adk} , {Adenosine} , {ATP} , {ADP} , {AMP}
 adenosylmethionine-8-amino-7-oxononanoate transaminase [8-Amino-7-oxononanoate] + [S-Adenosyl-L-methionine] ↔ [S-Adenosyl-4-methylthio-2-oxobutanoate] + [7,8-Diaminononanoate];   {bioA} , {8-Amino-7-oxononanoate} , {S-Adenosyl-L-methionine} , {S-Adenosyl-4-methylthio-2-oxobutanoate} , {7,8-Diaminononanoate}
 adenylate kinase [AMP] + [ATP] ↔ 2.0 × [ADP];   {adk} , {AMP} , {ATP} , {ADP}
 adenylosuccinate lyase [(S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate] ↔ [5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide] + [Fumarate];   {purB} , {(S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate} , {5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide} , {Fumarate}
 adenylosuccinate synthase [L-Aspartate] + [GTP] + [IMP] ↔ [N6-(1,2-Dicarboxyethyl)-AMP] + [GDP] + [Phosphate];   {purA} , {L-Aspartate} , {GTP} , {IMP} , {N6-(1,2-Dicarboxyethyl)-AMP} , {GDP} , {Phosphate}
 adenylsuccinate lyase [N6-(1,2-Dicarboxyethyl)-AMP] ↔ [AMP] + [Fumarate];   {purB} , {N6-(1,2-Dicarboxyethyl)-AMP} , {AMP} , {Fumarate}
 adenylyl-sulfate kinase [Adenosine 5'-phosphosulfate] + [ATP] ↔ [ADP] + [3'-Phosphoadenylyl sulfate];   {cysC} , {Adenosine 5'-phosphosulfate} , {ATP} , {ADP} , {3'-Phosphoadenylyl sulfate}
 alanine racemase [L-Alanine] ↔ [D-Alanine];   {dadX} , {alr} , {L-Alanine} , {D-Alanine}
 anthranilate phosphoribosyltransferase [Anthranilate] + [5-Phospho-alpha-D-ribose 1-diphosphate] ↔ [Diphosphate] + [N-(5-Phospho-D-ribosyl)anthranilate];   {trpD} , {Anthranilate} , {5-Phospho-alpha-D-ribose 1-diphosphate} , {Diphosphate} , {N-(5-Phospho-D-ribosyl)anthranilate}
 anthranilate synthase [chorismate] + [L-Glutamine] ↔ [Anthranilate] + [L-Glutamate] + [Pyruvate];   {trpE} , {trpD} , {chorismate} , {L-Glutamine} , {Anthranilate} , {L-Glutamate} , {Pyruvate}
 arabinose-5-phosphate isomerase [D-Ribulose 5-phosphate] ↔ [D-Arabinose 5-phosphate];   {kdsD} , {gutQ} , {D-Ribulose 5-phosphate} , {D-Arabinose 5-phosphate}
 argininosuccinate lyase [N(omega)-(L-Arginino)succinate] ↔ [L-Arginine] + [Fumarate];   {argH} , {N(omega)-(L-Arginino)succinate} , {L-Arginine} , {Fumarate}
 argininosuccinate synthase [L-Aspartate] + [ATP] + [L-Citrulline] ↔ [AMP] + [N(omega)-(L-Arginino)succinate] + [Diphosphate];   {argG} , {L-Aspartate} , {ATP} , {L-Citrulline} , {AMP} , {N(omega)-(L-Arginino)succinate} , {Diphosphate}
 asparagine synthetase [L-Aspartate] + [ATP] + [Ammonium] ↔ [AMP] + [L-Asparagine] + [Diphosphate];   {asnA} , {L-Aspartate} , {ATP} , {Ammonium} , {AMP} , {L-Asparagine} , {Diphosphate}
 aspartate 1-decarboxylase [L-Aspartate] ↔ [beta-Alanine] + [CO2];   {panD} , {L-Aspartate} , {beta-Alanine} , {CO2}
 aspartate carbamoyltransferase [L-Aspartate] + [Carbamoyl phosphate] ↔ [N-Carbamoyl-L-aspartate] + [Phosphate];   {pyrB} , {pyrI} , {L-Aspartate} , {Carbamoyl phosphate} , {N-Carbamoyl-L-aspartate} , {Phosphate}
 aspartate kinase [L-Aspartate] + [ATP] ↔ [4-Phospho-L-aspartate] + [ADP];   {lysC} , {thrA} , {metL} , {L-Aspartate} , {ATP} , {4-Phospho-L-aspartate} , {ADP}
 aspartate transaminase [L-Glutamate] + [Oxaloacetate] ↔ [2-Oxoglutarate] + [L-Aspartate];   {aspC} , {L-Glutamate} , {Oxaloacetate} , {2-Oxoglutarate} , {L-Aspartate}
 aspartate-semialdehyde dehydrogenase [4-Phospho-L-aspartate] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [L-Aspartate 4-semialdehyde] + [Nicotinamide adenine dinucleotide phosphate] + [Phosphate];   {asd} , {4-Phospho-L-aspartate} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {L-Aspartate 4-semialdehyde} , {Nicotinamide adenine dinucleotide phosphate} , {Phosphate}
 ATP phosphoribosyltransferase [ATP] + [5-Phospho-alpha-D-ribose 1-diphosphate] ↔ [Diphosphate] + [1-(5-Phosphoribosyl)-ATP];   {hisG} , {ATP} , {5-Phospho-alpha-D-ribose 1-diphosphate} , {Diphosphate} , {1-(5-Phosphoribosyl)-ATP}
 Biotin synthase [[2Fe-2S] iron-sulfur cluster] + [S-Adenosyl-L-methionine] + [Dethiobiotin] ↔ [[2Fe-1S] desulfurated iron-sulfur cluster] + [Biotin] + [5'-Deoxyadenosine] + [L-Methionine];   {bioB} , {[2Fe-2S] iron-sulfur cluster} , {S-Adenosyl-L-methionine} , {Dethiobiotin} , {[2Fe-1S] desulfurated iron-sulfur cluster} , {Biotin} , {5'-Deoxyadenosine} , {L-Methionine}
 bis-molybdenum cofactor synthase [molybdenum cofactor] + [adenylated molybdopterin] ↔ [AMP] + [bis-molybdenum cofactor] + [Cu2+];   {moeA} , {molybdenum cofactor} , {adenylated molybdopterin} , {AMP} , {bis-molybdenum cofactor} , {Cu2+}
 bis-molybdopterin guanine dinucleotide synthase [bis-molybdopterin mono-guanine dinucleotide] + [GTP] ↔ [bis-molybdopterin guanine dinucleotide] + [Diphosphate];   {mobA} , {mobB} , {bis-molybdopterin mono-guanine dinucleotide} , {GTP} , {bis-molybdopterin guanine dinucleotide} , {Diphosphate}
 bis-molybdopterin guanine dinucleotide synthase (single GDP) [bis-molybdenum cofactor] + [GTP] ↔ [bis-molybdopterin mono-guanine dinucleotide] + [Diphosphate];   {mobA} , {mobB} , {bis-molybdenum cofactor} , {GTP} , {bis-molybdopterin mono-guanine dinucleotide} , {Diphosphate}
 Carbamate kinase [ATP] + [CO2] + [Ammonium] ↔ [ADP] + [Carbamoyl phosphate];   {yqeA} , {arcC} , {yahI} , {ATP} , {CO2} , {Ammonium} , {ADP} , {Carbamoyl phosphate}
 CDP-diacylglycerol synthetase (n-C16:0) [CTP] + [1,2-dihexadecanoyl-sn-glycerol 3-phosphate] ↔ [CDP-1,2-dihexadecanoylglycerol] + [Diphosphate];   {cdsA} , {CTP} , {1,2-dihexadecanoyl-sn-glycerol 3-phosphate} , {CDP-1,2-dihexadecanoylglycerol} , {Diphosphate}
 CDP-diacylglycerol synthetase (n-C16:1) [CTP] + [1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate] ↔ [CDP-1,2-dihexadec-9-enoylglycerol] + [Diphosphate];   {cdsA} , {CTP} , {1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate} , {CDP-1,2-dihexadec-9-enoylglycerol} , {Diphosphate}
 chorismate mutase [chorismate] ↔ [Prephenate];   {pheA} , {tyrA} , {chorismate} , {Prephenate}
 Chorismate pyruvate lyase [chorismate] ↔ [4-Hydroxybenzoate] + [Pyruvate];   {ubiC} , {chorismate} , {4-Hydroxybenzoate} , {Pyruvate}
 chorismate synthase [5-O-(1-Carboxyvinyl)-3-phosphoshikimate] ↔ [chorismate] + [Phosphate];   {aroC} , {5-O-(1-Carboxyvinyl)-3-phosphoshikimate} , {chorismate} , {Phosphate}
 citrate synthase [Acetyl-CoA] + [Oxaloacetate] ↔ [Citrate] + [Coenzyme A];   {gltA} , {Acetyl-CoA} , {Oxaloacetate} , {Citrate} , {Coenzyme A}
 coproporphyrinogen oxidase (O2 required) [Coproporphyrinogen III] + [O2] ↔ 2.0 × [CO2] + [Protoporphyrinogen IX];   {hemF} , {Coproporphyrinogen III} , {O2} , {CO2} , {Protoporphyrinogen IX}
 CTP synthase (glutamine) [ATP] + [L-Glutamine] + [UTP] ↔ [ADP] + [CTP] + [L-Glutamate] + [Phosphate];   {pyrG} , {ATP} , {L-Glutamine} , {UTP} , {ADP} , {CTP} , {L-Glutamate} , {Phosphate}
 cyclic pyranopterin monophosphate synthase [GTP] ↔ [cyclic pyranopterin monophosphate] + [Diphosphate];   {moaA} , {moaC} , {GTP} , {cyclic pyranopterin monophosphate} , {Diphosphate}
 cystathionine b-lyase [L-Cystathionine] ↔ [L-Homocysteine] + [Ammonium] + [Pyruvate];   {metC} , {malY} , {L-Cystathionine} , {L-Homocysteine} , {Ammonium} , {Pyruvate}
 cysteine synthase [O-Acetyl-L-serine] + [Hydrogen sulfide] ↔ [Acetate] + [L-Cysteine];   {cysM} , {cysK} , {O-Acetyl-L-serine} , {Hydrogen sulfide} , {Acetate} , {L-Cysteine}
 cytidylate kinase (CMP) [ATP] + [CMP] ↔ [ADP] + [CDP];   {cmk} , {ATP} , {CMP} , {ADP} , {CDP}
 D-alanine-D-alanine ligase (reversible) 2.0 × [D-Alanine] + [ATP] ↔ [ADP] + [D-Alanyl-D-alanine] + [Phosphate];   {ddlB} , {ddlA} , {D-Alanine} , {ATP} , {ADP} , {D-Alanyl-D-alanine} , {Phosphate}
 dephospho-CoA kinase [ATP] + [Dephospho-CoA] ↔ [ADP] + [Coenzyme A];   {coaE} , {ATP} , {Dephospho-CoA} , {ADP} , {Coenzyme A}
 dethiobiotin synthase [ATP] + [CO2] + [7,8-Diaminononanoate] ↔ [ADP] + [Dethiobiotin] + [Phosphate];   {bioD1} , {ATP} , {CO2} , {7,8-Diaminononanoate} , {ADP} , {Dethiobiotin} , {Phosphate}
 diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp) [2,5-Diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate] ↔ [5-Amino-6-(5'-phosphoribosylamino)uracil] + [Ammonium];   {ribD} , {2,5-Diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate} , {5-Amino-6-(5'-phosphoribosylamino)uracil} , {Ammonium}
 diaminopimelate decarboxylase [meso-2,6-Diaminoheptanedioate] ↔ [CO2] + [L-Lysine];   {lysA} , {meso-2,6-Diaminoheptanedioate} , {CO2} , {L-Lysine}
 diaminopimelate epimerase [LL-2,6-Diaminoheptanedioate] ↔ [meso-2,6-Diaminoheptanedioate];   {dapF} , {LL-2,6-Diaminoheptanedioate} , {meso-2,6-Diaminoheptanedioate}
 dihydoorotic acid dehydrogenase (quinone8) [(S)-Dihydroorotate] + [Ubiquinone-8] ↔ [Orotate] + [Ubiquinol-8];   {pyrD} , {(S)-Dihydroorotate} , {Ubiquinone-8} , {Orotate} , {Ubiquinol-8}
 dihydrodipicolinate reductase (NADPH) [2,3-Dihydrodipicolinate] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [Nicotinamide adenine dinucleotide phosphate] + [2,3,4,5-Tetrahydrodipicolinate];   {dapB} , {2,3-Dihydrodipicolinate} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {Nicotinamide adenine dinucleotide phosphate} , {2,3,4,5-Tetrahydrodipicolinate}
 dihydrodipicolinate synthase [L-Aspartate 4-semialdehyde] + [Pyruvate] ↔ [2,3-Dihydrodipicolinate];   {dapA} , {L-Aspartate 4-semialdehyde} , {Pyruvate} , {2,3-Dihydrodipicolinate}
 dihydrofolate reductase [7,8-Dihydrofolate] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [Nicotinamide adenine dinucleotide phosphate] + [5,6,7,8-Tetrahydrofolate];   {folM} , {folA} , {7,8-Dihydrofolate} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {Nicotinamide adenine dinucleotide phosphate} , {5,6,7,8-Tetrahydrofolate}
 dihydrofolate synthase [ATP] + [Dihydropteroate] + [L-Glutamate] ↔ [ADP] + [7,8-Dihydrofolate] + [Phosphate];   {folC} , {ATP} , {Dihydropteroate} , {L-Glutamate} , {ADP} , {7,8-Dihydrofolate} , {Phosphate}
 dihydroneopterin aldolase reversible [Dihydroneopterin] ↔ [6-hydroxymethyl dihydropterin] + [Glycolaldehyde];   {folB} , {Dihydroneopterin} , {6-hydroxymethyl dihydropterin} , {Glycolaldehyde}
 Dihydroneopterin triphosphate pyrophosphatase [2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate] ↔ [Dihydroneopterin monophosphate] + [Diphosphate];   {mutT} , {nudB} , {2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate} , {Dihydroneopterin monophosphate} , {Diphosphate}
 dihydroorotase [N-Carbamoyl-L-aspartate] ↔ [(S)-Dihydroorotate];   {pyrC} , {N-Carbamoyl-L-aspartate} , {(S)-Dihydroorotate}
 dihydroorotic acid (menaquinone-8) [(S)-Dihydroorotate] + [Menaquinone 8] ↔ [Menaquinol 8] + [Orotate];   {pyrD} , {(S)-Dihydroorotate} , {Menaquinone 8} , {Menaquinol 8} , {Orotate}
 dihydropteroate synthase [4-Aminobenzoate] + [6-hydroxymethyl-dihydropterin pyrophosphate] ↔ [Dihydropteroate] + [Diphosphate];   {folP} , {4-Aminobenzoate} , {6-hydroxymethyl-dihydropterin pyrophosphate} , {Dihydropteroate} , {Diphosphate}
 dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) [(R)-2,3-Dihydroxy-3-methylbutanoate] ↔ [3-Methyl-2-oxobutanoate];   {ilvD} , {(R)-2,3-Dihydroxy-3-methylbutanoate} , {3-Methyl-2-oxobutanoate}
 Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) [(R)-2,3-Dihydroxy-3-methylpentanoate] ↔ [(S)-3-Methyl-2-oxopentanoate];   {ilvD} , {(R)-2,3-Dihydroxy-3-methylpentanoate} , {(S)-3-Methyl-2-oxopentanoate}
 dimethylallyltranstransferase [Dimethylallyl diphosphate] + [Isopentenyl diphosphate] ↔ [Geranyl diphosphate] + [Diphosphate];   {ispA} , {Dimethylallyl diphosphate} , {Isopentenyl diphosphate} , {Geranyl diphosphate} , {Diphosphate}
 dTMP kinase [ATP] + [dTMP] ↔ [ADP] + [dTDP];   {tmk} , {ATP} , {dTMP} , {ADP} , {dTDP}
 dUTP diphosphatase [dUTP] ↔ [dUMP] + [Diphosphate];   {dut} , {nudI} , {dUTP} , {dUMP} , {Diphosphate}
 enolase [D-Glycerate 2-phosphate] ↔ [Phosphoenolpyruvate];   {eno} , {D-Glycerate 2-phosphate} , {Phosphoenolpyruvate}
 Enoylglutaryl-[ACP] methyl ester reductase [Enoylglutaryl-[acyl-carrier protein] methyl ester] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [Glutaryl-[acyl-carrier protein] methyl ester] + [Nicotinamide adenine dinucleotide phosphate];   {fabI} , {Enoylglutaryl-[acyl-carrier protein] methyl ester} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {Glutaryl-[acyl-carrier protein] methyl ester} , {Nicotinamide adenine dinucleotide phosphate}
 Enoylpimeloyl-[ACP] methyl ester reductase [Enoylpimeloyl-[acyl-carrier protein] methyl ester] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [Nicotinamide adenine dinucleotide phosphate] + [Pimeloyl-[acyl-carrier protein] methyl ester];   {fabI} , {Enoylpimeloyl-[acyl-carrier protein] methyl ester} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {Nicotinamide adenine dinucleotide phosphate} , {Pimeloyl-[acyl-carrier protein] methyl ester}
 Erythronate 4-phosphate (4per) dehydrogenase [4-Phospho-D-erythronate] + [Nicotinamide adenine dinucleotide] ↔ [Nicotinamide adenine dinucleotide - reduced] + [2-Oxo-3-hydroxy-4-phosphobutanoate];   {pdxB} , {4-Phospho-D-erythronate} , {Nicotinamide adenine dinucleotide} , {Nicotinamide adenine dinucleotide - reduced} , {2-Oxo-3-hydroxy-4-phosphobutanoate}
 Erythrose 4-phosphate dehydrogenase [D-Erythrose 4-phosphate] + [Nicotinamide adenine dinucleotide] ↔ [4-Phospho-D-erythronate] + [Nicotinamide adenine dinucleotide - reduced];   {epd} , {gapA} , {D-Erythrose 4-phosphate} , {Nicotinamide adenine dinucleotide} , {4-Phospho-D-erythronate} , {Nicotinamide adenine dinucleotide - reduced}
 FAD reductase [Flavin adenine dinucleotide oxidized] + [Nicotinamide adenine dinucleotide - reduced] ↔ [Flavin adenine dinucleotide reduced] + [Nicotinamide adenine dinucleotide];   {fre} , {Flavin adenine dinucleotide oxidized} , {Nicotinamide adenine dinucleotide - reduced} , {Flavin adenine dinucleotide reduced} , {Nicotinamide adenine dinucleotide}
 fatty-acid-CoA thioesterase (dodecanoate) [Dodecanoyl-CoA (n-C12:0CoA)] ↔ [Coenzyme A] + [Dodecanoate (n-C12:0)];   {tesB} , {Dodecanoyl-CoA (n-C12:0CoA)} , {Coenzyme A} , {Dodecanoate (n-C12:0)}
 fatty-acid-CoA thioesterase (hexadecanoate) [Palmitoyl-CoA (n-C16:0CoA)] ↔ [Coenzyme A] + [Hexadecanoate (n-C16:0)];   {tesB} , {Palmitoyl-CoA (n-C16:0CoA)} , {Coenzyme A} , {Hexadecanoate (n-C16:0)}
 fatty-acid-CoA thioesterase (hexadecenoate) [Hexadecenoyl-CoA (n-C16:1CoA)] ↔ [Coenzyme A] + [Hexadecenoate (n-C16:1)];   {tesB} , {Hexadecenoyl-CoA (n-C16:1CoA)} , {Coenzyme A} , {Hexadecenoate (n-C16:1)}
 Ferrochelatase [Fe2+] + [Protoporphyrin] ↔ [Protoheme];   {hemH} , {Fe2+} , {Protoporphyrin} , {Protoheme}
 FMN adenylyltransferase [ATP] + [FMN] ↔ [Flavin adenine dinucleotide oxidized] + [Diphosphate];   {ribF} , {ATP} , {FMN} , {Flavin adenine dinucleotide oxidized} , {Diphosphate}
 formate-tetrahydrofolate ligase [ATP] + [Formate] + [5,6,7,8-Tetrahydrofolate] ↔ [10-Formyltetrahydrofolate] + [ADP] + [Phosphate];   {ATP} , {Formate} , {5,6,7,8-Tetrahydrofolate} , {10-Formyltetrahydrofolate} , {ADP} , {Phosphate}
 fumarase [Fumarate] ↔ [L-Malate];   {fumB} , {fumC} , {fumA} , {Fumarate} , {L-Malate}
 GAR transformylase-T [ATP] + [Formate] + [N1-(5-Phospho-D-ribosyl)glycinamide] ↔ [ADP] + [N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide] + [Phosphate];   {purT} , {ATP} , {Formate} , {N1-(5-Phospho-D-ribosyl)glycinamide} , {ADP} , {N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide} , {Phosphate}
 geranyltranstransferase [Geranyl diphosphate] + [Isopentenyl diphosphate] ↔ [Farnesyl diphosphate] + [Diphosphate];   {ispA} , {Geranyl diphosphate} , {Isopentenyl diphosphate} , {Farnesyl diphosphate} , {Diphosphate}
 glucosamine-1-phosphate N-acetyltransferase [Acetyl-CoA] + [D-Glucosamine 1-phosphate] ↔ [N-Acetyl-D-glucosamine 1-phosphate] + [Coenzyme A];   {glmU} , {Acetyl-CoA} , {D-Glucosamine 1-phosphate} , {N-Acetyl-D-glucosamine 1-phosphate} , {Coenzyme A}
 glucose 6-phosphate dehydrogenase [D-Glucose 6-phosphate] + [Nicotinamide adenine dinucleotide phosphate] ↔ [6-phospho-D-glucono-1,5-lactone] + [Nicotinamide adenine dinucleotide phosphate - reduced];   {zwf} , {D-Glucose 6-phosphate} , {Nicotinamide adenine dinucleotide phosphate} , {6-phospho-D-glucono-1,5-lactone} , {Nicotinamide adenine dinucleotide phosphate - reduced}
 glucose-6-phosphate isomerase [D-Glucose 6-phosphate] ↔ [D-Fructose 6-phosphate];   {pgi} , {D-Glucose 6-phosphate} , {D-Fructose 6-phosphate}
 glutamate 5-kinase [ATP] + [L-Glutamate] ↔ [ADP] + [L-Glutamate 5-phosphate];   {proB} , {ATP} , {L-Glutamate} , {ADP} , {L-Glutamate 5-phosphate}
 glutamate dehydrogenase (NADP) [2-Oxoglutarate] + [Nicotinamide adenine dinucleotide phosphate - reduced] + [Ammonium] ↔ [L-Glutamate] + [Nicotinamide adenine dinucleotide phosphate];   {gdhA} , {2-Oxoglutarate} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {Ammonium} , {L-Glutamate} , {Nicotinamide adenine dinucleotide phosphate}
 glutamate racemase [L-Glutamate] ↔ [D-Glutamate];   {murI} , {L-Glutamate} , {D-Glutamate}
 glutamate-1-semialdehyde aminotransferase [L-Glutamate 1-semialdehyde] ↔ [5-Amino-4-oxopentanoate];   {hemL} , {L-Glutamate 1-semialdehyde} , {5-Amino-4-oxopentanoate}
 glutamate-5-semialdehyde dehydrogenase [L-Glutamate 5-phosphate] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [L-Glutamate 5-semialdehyde] + [Nicotinamide adenine dinucleotide phosphate] + [Phosphate];   {proA} , {L-Glutamate 5-phosphate} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {L-Glutamate 5-semialdehyde} , {Nicotinamide adenine dinucleotide phosphate} , {Phosphate}
 glutamine phosphoribosyldiphosphate amidotransferase [L-Glutamine] + [5-Phospho-alpha-D-ribose 1-diphosphate] ↔ [L-Glutamate] + [Diphosphate] + [5-Phospho-beta-D-ribosylamine];   {purF} , {L-Glutamine} , {5-Phospho-alpha-D-ribose 1-diphosphate} , {L-Glutamate} , {Diphosphate} , {5-Phospho-beta-D-ribosylamine}
 glutamine synthetase [ATP] + [L-Glutamate] + [Ammonium] ↔ [ADP] + [L-Glutamine] + [Phosphate];   {glnA} , {puuA} , {ATP} , {L-Glutamate} , {Ammonium} , {ADP} , {L-Glutamine} , {Phosphate}
 glutamine-fructose-6-phosphate transaminase [D-Fructose 6-phosphate] + [L-Glutamine] ↔ [D-Glucosamine 6-phosphate] + [L-Glutamate];   {glmS} , {D-Fructose 6-phosphate} , {L-Glutamine} , {D-Glucosamine 6-phosphate} , {L-Glutamate}
 glutamyl-tRNA reductase [L-Glutamyl-tRNA(Glu)] + [Nicotinamide adenine dinucleotide phosphate - reduced] ↔ [L-Glutamate 1-semialdehyde] + [Nicotinamide adenine dinucleotide phosphate] + [tRNA (Glu)];   {hemA} , {L-Glutamyl-tRNA(Glu)} , {Nicotinamide adenine dinucleotide phosphate - reduced} , {L-Glutamate 1-semialdehyde} , {Nicotinamide adenine dinucleotide phosphate} , {tRNA (Glu)}
 Glutamyl-tRNA synthetase [ATP] + [L-Glutamate] + [tRNA (Glu)] ↔ [AMP] + [L-Glutamyl-tRNA(Glu)] + [Diphosphate];   {gltX} , {ATP} , {L-Glutamate} , {tRNA (Glu)} , {AMP} , {L-Glutamyl-tRNA(Glu)} , {Diphosphate}
 glyceraldehyde-3-phosphate dehydrogenase [Glyceraldehyde 3-phosphate] + [Nicotinamide adenine dinucleotide] + [Phosphate] ↔ [3-Phospho-D-glyceroyl phosphate] + [Nicotinamide adenine dinucleotide - reduced];   {gapA} , {Glyceraldehyde 3-phosphate} , {Nicotinamide adenine dinucleotide} , {Phosphate} , {3-Phospho-D-glyceroyl phosphate} , {Nicotinamide adenine dinucleotide - reduced}