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BIOMD0000000397 - Sivakumar2011_WntSignalingPathway

 

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Reference Publication
Publication ID: 21978399
Sivakumar KC, Dhanesh SB, Shobana S, James J, Mundayoor S.
A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways.
OMICS 2011 Oct; 15(10): 729-737
Bioinformatics Facility, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.  [more]
Model
Original Model: BIOMD0000000397.origin
Submitter: KC Sivakumar
Submission ID: MODEL1101270002
Submission Date: 27 Jan 2011 04:41:28 UTC
Last Modification Date: 02 Jun 2014 13:13:31 UTC
Creation Date: 02 Nov 2011 14:46:25 UTC
Encoders:  Vijayalakshmi Chelliah
   KC Sivakumar
set #1
bqmodel:isDerivedFrom PANTHER Pathway P00057
set #2
bqbiol:occursIn Cell Type Ontology neuronal stem cell
set #3
bqbiol:occursIn Taxonomy Mammalia
set #4
bqbiol:isVersionOf Gene Ontology canonical Wnt signaling pathway
Notes
Sivakumar2011_WntSignalingPathway
The secreted protein Wnt activates the heptahelical receptor Frizzled on nieghboring cells. Activation of Frizzled causes the recruitment of additional membrane proteins which in turn result in 1) the activation of the protein Dishevelled via phosphorylation and 2) the activation of a heterotrimeric G protein of unknown type. Activation of Dishevelled results in the down-regulation of the Beta-Catenin destruction complex which causes ubiquitination of Beta-Catenin and its ultimate degradation via the proteasome. Inhibition of the Beta-Catenin destruction complex yields a higher cytosolic concentration of Beta-Catenin, which enters the nucleus, binds various transcriptional regulatory molecules including the TCF/LEF class of proteins, and results in the transcription of TCF/LEF target genes. Activation of the heterotrimeric G-protein pathway in turn activates Phospholipase C which in turn catalyzes the catalysis of PI(4,5)P2 into DAG and IP3.

Reference:

This model is described in the article:

Sivakumar KC, Dhanesh SB, Shobana S, James J, Mundayoor S.
OMICS 2011 Oct; 15(10): 729-737

Abstract:

The Notch, Sonic Hedgehog (Shh), Wnt, and EGF pathways have long been known to influence cell fate specification in the developing nervous system. Here we attempted to evaluate the contemporary knowledge about neural stem cell differentiation promoted by various drug-based regulations through a systems biology approach. Our model showed the phenomenon of DAPT-mediated antagonism of Enhancer of split [E(spl)] genes and enhancement of Shh target genes by a SAG agonist that were effectively demonstrated computationally and were consistent with experimental studies. However, in the case of model simulation of Wnt and EGF pathways, the model network did not supply any concurrent results with experimental data despite the fact that drugs were added at the appropriate positions. This paves insight into the potential of crosstalks between pathways considered in our study. Therefore, we manually developed a map of signaling crosstalk, which included the species connected by representatives from Notch, Shh, Wnt, and EGF pathways and highlighted the regulation of a single target gene, Hes-1, based on drug-induced simulations. These simulations provided results that matched with experimental studies. Therefore, these signaling crosstalk models complement as a tool toward the discovery of novel regulatory processes involved in neural stem cell maintenance, proliferation, and differentiation during mammalian central nervous system development. To our knowledge, this is the first report of a simple crosstalk map that highlights the differential regulation of neural stem cell differentiation and underscores the flow of positive and negative regulatory signals modulated by drugs.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Model
Publication ID: 21978399 Submission Date: 27 Jan 2011 04:41:28 UTC Last Modification Date: 02 Jun 2014 13:13:31 UTC Creation Date: 02 Nov 2011 14:46:25 UTC
Mathematical expressions
Reactions
r68 r1 r5 r47
r48 r54 r58 r63
r66 r88 r90 r91
r92 r96 r98 r99
r102 r103 r105 r106
r107 r104 r85 r65
r64 re65 re64 r67
r86      
Physical entities
Compartments Species
default Wnt    
Plasma Membrane Complex_br_(Wnt/Frizzled) Frizzled Complex_br_(Frizzled/Wnt/_br_LRP5/6)
LRP5/6 Casein Kinase 1 Casein Kinase 2
ATP ADP Glycogen Synthase Kinase-3_Beta_
Diversin Complex_br_(Ebi/Siah-1) Complex_br_(Siah-1/Ebi)
FRAT Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo) Complex_br_(Axin/PP2A/_br_Adenomatous Polyposis Coli)
Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/Casein Kinase 1/_br_Glycogen Synthase Kinase-3_Beta_/PP2A) Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A) _Beta_-Catenin
Complex_br_(Adenomatous Polyposis Coli/Axin/_br__Beta_-Catenin/PP2A) Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/_Beta_-Catenin/_br_PP2A) Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/_Beta_-Catenin/_br_Siah-1/Ebi)
Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A/_br_Diversin/Casein Kinase 1) Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Glycogen Synthase Kinase-3_Beta_/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1) Ubiquitin
_Beta_-Catenin _Beta_-Catenin Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Siah-1/Ebi/_br_Axin/PP2A)
Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A) Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo) Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo/Casein Kinase 2)
Complex_br_(Dishevelled/Casein Kinase 2/_br_Beta-Arrestin/Frodo/_br_FRAT) _beta_TrCP Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)
Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_) Complex_br_(_beta_TrCP/_Beta_-Catenin) 6 bromoindirubin 3'oxime
     
Nucleus Pygo CBP SWI/SNF
Bcl9 Wnt Target Genes Complex_br_(TCF/Smad4)
_Beta_-Catenin Complex_br_(TCF/Smad4/_br__Beta_-Catenin) Complex_br_(TCF/_Beta_-Catenin/_br_Smad4/Bcl9)
Complex_br_(Bcl9/_Beta_-Catenin/_br_TCF/Smad4/_br_Pygo) Complex_br_(_Beta_-Catenin/TCF/_br_Smad4/Bcl9/_br_Pygo/SWI/_br_SNF) Complex_br_(Bcl9/Pygo/../Smad4)
Cell Membrane Wnt    
Global parameters
kass_r1 kdiss_r1 kass_r5 kdiss_r5
kass_r47 kdiss_r47 kass_r48 kdiss_r48
kass_r54 kdiss_r54 kass_r58 kdiss_r58
kass_r63 kdiss_r63 kass_r64 kdiss_r64
kass_r65 kdiss_r65 kass_r66 kdiss_r66
kass_r68 kass_r88 kdiss_r88 kass_r90
kdiss_r90 kass_r91 kdiss_r91 kass_r92
kdiss_r92 kass_r96 kdiss_r96 kass_r98
kdiss_r98 kass_r99 kdiss_r99 kass_r102
kdiss_r102 kass_r103 kdiss_r103 kass_r105
kdiss_r105 kass_r106 kdiss_r106 kass_r107
kdiss_r107 kass_r104_s30 kdiss_r104_s30 kass_r85_s30
kdiss_r85_s30 kass_re65 kass_re64 kass_r86_s37
kdiss_r86_s37 kass_r67 kdiss_r67 kI_r86_s304
Reactions (29)
 
 r68 [Complex_br_(Bcl9/Pygo/../Smad4)] → [Wnt Target Genes];  
 
 r1 [Wnt] + [Frizzled] ↔ [Complex_br_(Wnt/Frizzled)];  
 
 r5 [LRP5/6] + [Complex_br_(Wnt/Frizzled)] ↔ [Complex_br_(Frizzled/Wnt/_br_LRP5/6)];  
 
 r47 [Complex_br_(Axin/PP2A/_br_Adenomatous Polyposis Coli)] + [_Beta_-Catenin] ↔ [Complex_br_(Adenomatous Polyposis Coli/Axin/_br__Beta_-Catenin/PP2A)];  
 
 r48 [Complex_br_(Adenomatous Polyposis Coli/Axin/_br__Beta_-Catenin/PP2A)] + [Diversin] ↔ [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/_Beta_-Catenin/_br_PP2A)];  
 
 r54 [Complex_br_(Adenomatous Polyposis Coli/Axin/_br__Beta_-Catenin/PP2A)] + [Complex_br_(Ebi/Siah-1)] ↔ [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/_Beta_-Catenin/_br_Siah-1/Ebi)];  
 
 r58 [_Beta_-Catenin] ↔ [_Beta_-Catenin];  
 
 r63 [Complex_br_(TCF/Smad4)] + [_Beta_-Catenin] ↔ [Complex_br_(TCF/Smad4/_br__Beta_-Catenin)];  
 
 r66 [Complex_br_(Bcl9/_Beta_-Catenin/_br_TCF/Smad4/_br_Pygo)] + [SWI/SNF] ↔ [Complex_br_(_Beta_-Catenin/TCF/_br_Smad4/Bcl9/_br_Pygo/SWI/_br_SNF)];  
 
 r88 [Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Glycogen Synthase Kinase-3_Beta_/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1)] + [_beta_TrCP] ↔ [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)];  
 
 r90 [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)] + [Ubiquitin] ↔ [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)];  
 
 r91 [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)] ↔ [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/Casein Kinase 1/_br_Glycogen Synthase Kinase-3_Beta_/PP2A)] + [Complex_br_(_beta_TrCP/_Beta_-Catenin)];  
 
 r92 [Complex_br_(_beta_TrCP/_Beta_-Catenin)] ↔ [_beta_TrCP] + [_Beta_-Catenin];  
 
 r96 [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/_Beta_-Catenin/_br_Siah-1/Ebi)] + [Ubiquitin] ↔ [Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Siah-1/Ebi/_br_Axin/PP2A)];  
 
 r98 [Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Siah-1/Ebi/_br_Axin/PP2A)] ↔ [Complex_br_(Siah-1/Ebi)] + [Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A)];  
 
 r99 [Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A)] ↔ [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A)] + [_Beta_-Catenin];  
 
 r102 [Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)] + [Casein Kinase 2] ↔ [Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo/Casein Kinase 2)];  
 
 r103 [Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo/Casein Kinase 2)] + [FRAT] ↔ [Complex_br_(Dishevelled/Casein Kinase 2/_br_Beta-Arrestin/Frodo/_br_FRAT)];  
 
 r105 [Complex_br_(Dishevelled/Casein Kinase 2/_br_Beta-Arrestin/Frodo/_br_FRAT)] ↔ [Glycogen Synthase Kinase-3_Beta_];  
 
 r106 [Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)] ↔ [Casein Kinase 1];  
 
 r107 [Wnt] ↔ [Wnt];  
 
 r104 [Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)] + [ATP] ↔ [Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)] + [ADP];   {Complex_br_(Frizzled/Wnt/_br_LRP5/6)} , {Casein Kinase 1}
 
 r85 [Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/_Beta_-Catenin/_br_PP2A)] + [ATP] ↔ [Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A/_br_Diversin/Casein Kinase 1)] + [ADP];   {Casein Kinase 1}
 
 r65 [Complex_br_(TCF/_Beta_-Catenin/_br_Smad4/Bcl9)] + [Pygo] ↔ [Complex_br_(Bcl9/_Beta_-Catenin/_br_TCF/Smad4/_br_Pygo)];  
 
 r64 [Complex_br_(TCF/Smad4/_br__Beta_-Catenin)] + [Bcl9] ↔ [Complex_br_(TCF/_Beta_-Catenin/_br_Smad4/Bcl9)];  
 
 re65 [_Beta_-Catenin] → [_Beta_-Catenin];  
 
 re64 [_Beta_-Catenin] → [_Beta_-Catenin];  
 
 r67 [Complex_br_(_Beta_-Catenin/TCF/_br_Smad4/Bcl9/_br_Pygo/SWI/_br_SNF)] + [CBP] ↔ [Complex_br_(Bcl9/Pygo/../Smad4)];  
 
 r86 [Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A/_br_Diversin/Casein Kinase 1)] + [ATP] + [ATP] + [ATP] ↔ [Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Glycogen Synthase Kinase-3_Beta_/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1)] + [ADP] + [ADP] + [ADP];   {Glycogen Synthase Kinase-3_Beta_} , {6 bromoindirubin 3'oxime}
 
   Spatial dimensions: 3.0  Compartment size: 1.0
 
 Wnt
Compartment: default
Initial amount: 0.0
 
 Plasma Membrane Spatial dimensions: 3.0  Compartment size: 1.0
 
 Complex_br_(Wnt/Frizzled)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Frizzled
Compartment: Plasma Membrane
Initial amount: 3.0
 
 Complex_br_(Frizzled/Wnt/_br_LRP5/6)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 LRP5/6
Compartment: Plasma Membrane
Initial amount: 3.0
 
 Casein Kinase 1
Compartment: Plasma Membrane
Initial amount: 1.0
 
 Casein Kinase 2
Compartment: Plasma Membrane
Initial amount: 3.0
 
 ATP
Compartment: Plasma Membrane
Initial amount: 1.0
 
 ADP
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Glycogen Synthase Kinase-3_Beta_
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Diversin
Compartment: Plasma Membrane
Initial amount: 1.0
 
 Complex_br_(Ebi/Siah-1)
Compartment: Plasma Membrane
Initial amount: 3.0
 
 Complex_br_(Siah-1/Ebi)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 FRAT
Compartment: Plasma Membrane
Initial amount: 3.0
 
 Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)
Compartment: Plasma Membrane
Initial amount: 3.0
 
 Complex_br_(Axin/PP2A/_br_Adenomatous Polyposis Coli)
Compartment: Plasma Membrane
Initial amount: 4.0
 
 Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/Casein Kinase 1/_br_Glycogen Synthase Kinase-3_Beta_/PP2A)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 _Beta_-Catenin
Compartment: Plasma Membrane
Initial amount: 5.0
 
 Complex_br_(Adenomatous Polyposis Coli/Axin/_br__Beta_-Catenin/PP2A)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/_Beta_-Catenin/_br_PP2A)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/_Beta_-Catenin/_br_Siah-1/Ebi)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A/_br_Diversin/Casein Kinase 1)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Glycogen Synthase Kinase-3_Beta_/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1)
Compartment: Plasma Membrane
Initial amount: 5.0
 
 Ubiquitin
Compartment: Plasma Membrane
Initial amount: 1.0
 
 _Beta_-Catenin
Compartment: Plasma Membrane
Initial amount: 0.0
 
 _Beta_-Catenin
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Siah-1/Ebi/_br_Axin/PP2A)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo/Casein Kinase 2)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Dishevelled/Casein Kinase 2/_br_Beta-Arrestin/Frodo/_br_FRAT)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 _beta_TrCP
Compartment: Plasma Membrane
Initial amount: 2.0
 
 Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 Complex_br_(_beta_TrCP/_Beta_-Catenin)
Compartment: Plasma Membrane
Initial amount: 0.0
 
 6 bromoindirubin 3'oxime
Compartment: Plasma Membrane
Initial amount: 0.5
 
 Nucleus Spatial dimensions: 3.0  Compartment size: 1.0
 
 Pygo
Compartment: Nucleus
Initial amount: 2.0
 
 CBP
Compartment: Nucleus
Initial amount: 2.0
 
 SWI/SNF
Compartment: Nucleus
Initial amount: 2.0
 
 Bcl9
Compartment: Nucleus
Initial amount: 2.0
 
 Wnt Target Genes
Compartment: Nucleus
Initial amount: 0.0
 
 Complex_br_(TCF/Smad4)
Compartment: Nucleus
Initial amount: 4.0
 
 _Beta_-Catenin
Compartment: Nucleus
Initial amount: 0.0
 
 Complex_br_(TCF/Smad4/_br__Beta_-Catenin)
Compartment: Nucleus
Initial amount: 0.0
 
 Complex_br_(TCF/_Beta_-Catenin/_br_Smad4/Bcl9)
Compartment: Nucleus
Initial amount: 0.0
 
 Complex_br_(Bcl9/_Beta_-Catenin/_br_TCF/Smad4/_br_Pygo)
Compartment: Nucleus
Initial amount: 0.0
 
 Complex_br_(_Beta_-Catenin/TCF/_br_Smad4/Bcl9/_br_Pygo/SWI/_br_SNF)
Compartment: Nucleus
Initial amount: 0.0
 
 Complex_br_(Bcl9/Pygo/../Smad4)
Compartment: Nucleus
Initial amount: 0.0
 
 Cell Membrane Spatial dimensions: 3.0  Compartment size: 1.0
 
 Wnt
Compartment: Cell Membrane
Initial amount: 5.0
 
Global Parameters (56)
 
   kass_r1
Value: 0.784
Constant
 
   kdiss_r1
Value: 0.82
Constant
 
   kass_r5
Value: 1.15
Constant
 
   kdiss_r5
Value: 0.92
Constant
 
   kass_r47
Value: 1.31
Constant
 
   kdiss_r47
Value: 0.81
Constant
 
   kass_r48
Value: 0.85
Constant
 
   kdiss_r48
Value: 1.36
Constant
 
   kass_r54
Value: 0.8
Constant
 
   kdiss_r54
Value: 1.7
Constant
 
   kass_r58
Value: 1.74
Constant
 
   kdiss_r58
Value: 0.25
Constant
 
   kass_r63
Value: 1.77
Constant
 
   kdiss_r63
Value: 0.61
Constant
 
   kass_r64
Value: 1.29
Constant
 
   kdiss_r64
Value: 0.72
Constant
 
   kass_r65
Value: 1.8
Constant
 
   kdiss_r65
Value: 0.004
Constant
 
   kass_r66
Value: 1.99
Constant
 
   kdiss_r66
Value: 0.036
Constant
 
   kass_r68
Value: 2.0
Constant
 
   kass_r88
Value: 0.2
Constant
 
   kdiss_r88
Value: 1.09
Constant
 
   kass_r90
Value: 0.27
Constant
 
   kdiss_r90
Value: 1.028
Constant
 
   kass_r91
Value: 0.36
Constant
 
   kdiss_r91
Value: 1.16
Constant
 
   kass_r92
Value: 0.58
Constant
 
   kdiss_r92
Value: 0.92
Constant
 
   kass_r96
Value: 1.45
Constant
 
   kdiss_r96
Value: 0.183
Constant
 
   kass_r98
Value: 1.97
Constant
 
   kdiss_r98
Value: 1.09
Constant
 
   kass_r99
Value: 0.51
Constant
 
   kdiss_r99
Value: 0.854
Constant
 
   kass_r102
Value: 0.163
Constant
 
   kdiss_r102
Value: 1.65
Constant
 
   kass_r103
Value: 0.45
Constant
 
   kdiss_r103
Value: 1.277
Constant
 
   kass_r105
Value: 0.48
Constant
 
   kdiss_r105
Value: 1.62
Constant
 
   kass_r106
Value: 0.05
Constant
 
   kdiss_r106
Value: 1.13
Constant
 
   kass_r107
Value: 0.91
Constant
 
   kdiss_r107
Value: 1.056
Constant
 
   kass_r104_s30
Value: 0.39
Constant
 
   kdiss_r104_s30
Value: 1.278
Constant
 
   kass_r85_s30
Value: 0.7
Constant
 
   kdiss_r85_s30
Value: 0.649
Constant
 
   kass_re65
Value: 1.68
Constant
 
   kass_re64
Value: 0.83
Constant
 
   kass_r86_s37
Value: 0.87
Constant
 
   kdiss_r86_s37
Value: 1.32
Constant
 
   kass_r67
Value: 0.86
Constant
 
   kdiss_r67
Value: 0.7
Constant
 
   kI_r86_s304
Value: 1.43
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000397

Curator's comment: (updated: 02 Nov 2011 14:43:11 GMT)

Figure 1C of the reference publication has been reproduced here. The inconsistency between this figure and that is presented in the paper has been discussed with the author. The model was simulated using Copasi v4.7 (Build 34).

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