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BIOMD0000000376 - Bertram2007_IsletCell_Oscillations

 

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Reference Publication
Publication ID: 17172305
Bertram R, Satin LS, Pedersen MG, Luciani DS, Sherman A.
Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets.
Biophys. J. 2007 Mar; 92(5): 1544-1555
Department of Mathematics and Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, Florida, USA. bertram@math.fsu.edu  [more]
Model
Original Model: CellML logo
Submitter: Lukas Endler
Submission ID: MODEL7889980156
Submission Date: 24 Mar 2009 11:54:20 UTC
Last Modification Date: 28 May 2014 20:39:27 UTC
Creation Date: 29 Sep 2011 22:13:00 UTC
Encoders:  Ishan Ajmera
   Catherine Lloyd
set #1
bqbiol:hasTaxon Taxonomy Homo sapiens
set #2
bqbiol:isVersionOf Gene Ontology regulation of type B pancreatic cell proliferation
Gene Ontology glycolytic process
Gene Ontology type B pancreatic cell proliferation
set #3
bqbiol:occursIn Brenda Tissue Ontology pancreatic beta cell
set #4
bqmodel:is BioModels Database Bertram2004_PancreaticBetaCell_modelB
Notes

This is the model described in the article:
Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets.
Bertram R, Satin LS, Pedersen MG, Luciani DS, Sherman A. Biophys J. 2007 Mar 1;92(5):1544-55. Pubmed ID: 17172305, doi: 10.1529/biophysj.106.097154.
Abstract:
Insulin secretion from pancreatic beta-cells is oscillatory, with a typical period of 2-7 min, reflecting oscillations in membrane potential and the cytosolic Ca(2+) concentration. Our central hypothesis is that the slow 2-7 min oscillations are due to glycolytic oscillations, whereas faster oscillations that are superimposed are due to Ca(2+) feedback onto metabolism or ion channels. We extend a previous mathematical model based on this hypothesis to include a more detailed description of mitochondrial metabolism. We demonstrate that this model can account for typical oscillatory patterns of membrane potential and Ca(2+) concentration in islets. It also accounts for temporal data on oxygen consumption in islets. A recent challenge to the notion that glycolytic oscillations drive slow Ca(2+) oscillations in islets are data showing that oscillations in Ca(2+), mitochondrial oxygen consumption, and NAD(P)H levels are all terminated by membrane hyperpolarization. We demonstrate that these data are in fact compatible with a model in which glycolytic oscillations are the key player in rhythmic islet activity. Finally, we use the model to address the recent finding that the activity of islets from some mice is uniformly fast, whereas that from islets of other mice is slow. We propose a mechanism for this dichotomy.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Bertram, Satin, Pedersen, Luciani, Sherman, 2007 version 02
The original CellML model was created and curated by:
Catherine May Lloyd
c.lloyd(at)auckland.ac.nz
The University of Auckland, Bioengineering Institute

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
For more information see the terms of use.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 17172305 Submission Date: 24 Mar 2009 11:54:20 UTC Last Modification Date: 28 May 2014 20:39:27 UTC Creation Date: 29 Sep 2011 22:13:00 UTC
Mathematical expressions
Rules
Assignment Rule (variable: Ik) Assignment Rule (variable: n_infinity) Assignment Rule (variable: m_infinity) Assignment Rule (variable: Ica)
Assignment Rule (variable: Ikca) Assignment Rule (variable: mgadp) Assignment Rule (variable: topo) Assignment Rule (variable: adp3m)
Assignment Rule (variable: JGPDH) Assignment Rule (variable: F6P) Assignment Rule (variable: topa2) Assignment Rule (variable: weight3)
Assignment Rule (variable: topa3) Assignment Rule (variable: weight5) Assignment Rule (variable: weight7) Assignment Rule (variable: weight9)
Assignment Rule (variable: weight11) Assignment Rule (variable: weight13) Assignment Rule (variable: weight15) Assignment Rule (variable: topb)
Assignment Rule (variable: JO) Assignment Rule (variable: NADm) Assignment Rule (variable: JPDH) Assignment Rule (variable: JHres)
Assignment Rule (variable: JGK_ms) Assignment Rule (variable: JHleak) Assignment Rule (variable: Juni) Assignment Rule (variable: JNaCa)
Assignment Rule (variable: Jmito) Assignment Rule (variable: ATPm) Assignment Rule (variable: JF1F0) Assignment Rule (variable: JHatp)
Assignment Rule (variable: RATm) Assignment Rule (variable: JANT) Assignment Rule (variable: atp) Assignment Rule (variable: atp4m)
Assignment Rule (variable: bottomo) Assignment Rule (variable: katpo) Assignment Rule (variable: Ikatp) Assignment Rule (variable: weight2)
Assignment Rule (variable: bottom2) Assignment Rule (variable: bottom3) Assignment Rule (variable: weight4) Assignment Rule (variable: topa4)
Assignment Rule (variable: bottom4) Assignment Rule (variable: topa5) Assignment Rule (variable: bottom5) Assignment Rule (variable: weight6)
Assignment Rule (variable: topa6) Assignment Rule (variable: bottom6) Assignment Rule (variable: topa7) Assignment Rule (variable: bottom7)
Assignment Rule (variable: weight8) Assignment Rule (variable: topa8) Assignment Rule (variable: topa9) Assignment Rule (variable: bottom8)
Assignment Rule (variable: bottom9) Assignment Rule (variable: weight10) Assignment Rule (variable: topa10) Assignment Rule (variable: bottom10)
Assignment Rule (variable: topa11) Assignment Rule (variable: bottom11) Assignment Rule (variable: weight12) Assignment Rule (variable: topa12)
Assignment Rule (variable: bottom12) Assignment Rule (variable: topa13) Assignment Rule (variable: bottom13) Assignment Rule (variable: weight14)
Assignment Rule (variable: topa14) Assignment Rule (variable: bottom14) Assignment Rule (variable: topa15) Assignment Rule (variable: bottom15)
Assignment Rule (variable: weight16) Assignment Rule (variable: topa16) Assignment Rule (variable: bottom16) Assignment Rule (variable: JPFK)
Assignment Rule (variable: JPFK_ms) Assignment Rule (variable: Jhyd) Assignment Rule (variable: Jmem) Assignment Rule (variable: Jleak)
Assignment Rule (variable: JSERCA) Assignment Rule (variable: Jer) Assignment Rule (variable: delta) Rate Rule (variable: Vm)
Rate Rule (variable: n) Rate Rule (variable: G6P) Rate Rule (variable: FBP) Rate Rule (variable: NADHm)
Rate Rule (variable: delta_psi) Rate Rule (variable: Cam) Rate Rule (variable: ADPm) Rate Rule (variable: adp)
Rate Rule (variable: c) Rate Rule (variable: Caer)    
Physical entities
Compartments Species
Compartment Vm n G6P
FBP NADHm delta_psi
Cam ADPm adp
c Caer  
Global parameters
cm Ik gK n_infinity
tau_n Ica gCa m_infinity
Ikca gkCa kd Ikatp
gkATP_ katpo topo bottomo
mgadp adp3m atp4m JGPDH
kGPDH F6P JPFK JPFK_ms
bottom1 weight1 topa1 k1
k2 k3 k4 VmaxPFK
weight2 topa2 bottom2 topa3
weight3 bottom3 f13 f43
f23 f42 f41 weight4
topa4 bottom4 weight5 topa5
bottom5 weight6 topa6 bottom6
weight7 topa7 bottom7 weight8
topa8 bottom8 weight9 topa9
bottom9 weight10 topa10 bottom10
weight11 topa11 bottom11 weight12
topa12 bottom12 weight13 topa13
bottom13 weight14 topa14 bottom14
weight15 topa15 bottom15 weight16
topa16 bottom16 topb lambda
JPDH p1 p2 p3
JGPDHbas JO p4 p5
p6 p7 NADm NADmtot
Cmito JHres p8 p9
p10 p11 JF1F0 p13
p14 p15 p16 JHatp
JGK_ms JGK JHleak p17
p18 JANT p19 p20
FRT RATm Juni p21
p22 JNaCa p23 p24
fmito Jmito ATPm Amtot
Jhyd khyd khydbas atp
atot fcyt Jmem kPMCA
alpha Cbas Jleak pleak
JSERCA kSERCA Jer fer
Vc_Ver gamma kappa delta
VK VCa AMP  
Reactions (0)
Rules (94)
 
 Assignment Rule (name: Ik) Ik = gK*n*(Vm-VK)
 
 Assignment Rule (name: n_infinity) n_infinity = 1/(1+exp((-(16+Vm))/5))
 
 Assignment Rule (name: m_infinity) m_infinity = 1/(1+exp((-(20+Vm))/12))
 
 Assignment Rule (name: Ica) Ica = gCa*m_infinity*(Vm-VCa)
 
 Assignment Rule (name: Ikca) Ikca = gkCa*c^2/(c^2+kd^2)*(Vm-VK)
 
 Assignment Rule (name: mgadp) mgadp = 0.165*adp
 
 Assignment Rule (name: topo) topo = 0.08*(1+2*mgadp/17)+0.89*(mgadp/17)^2
 
 Assignment Rule (name: adp3m) adp3m = 0.135*adp
 
 Assignment Rule (name: JGPDH) JGPDH = kGPDH*FBP^(1/2)
 
 Assignment Rule (name: F6P) F6P = 0.3*G6P
 
 Assignment Rule (name: topa2) topa2 = topa1
 
 Assignment Rule (name: weight3) weight3 = F6P^2/k3
 
 Assignment Rule (name: topa3) topa3 = topa2+weight3
 
 Assignment Rule (name: weight5) weight5 = FBP/k2
 
 Assignment Rule (name: weight7) weight7 = FBP*F6P^2/(k2*f23*k3)
 
 Assignment Rule (name: weight9) weight9 = AMP/k1
 
 Assignment Rule (name: weight11) weight11 = AMP*F6P^2/(k1*k3*f13)
 
 Assignment Rule (name: weight13) weight13 = AMP*FBP/(k1*k2)
 
 Assignment Rule (name: weight15) weight15 = AMP*FBP*F6P^2/(k1*k2*f23*f13*k3)
 
 Assignment Rule (name: topb) topb = weight15
 
 Assignment Rule (name: JO) JO = p4*NADHm/(p5+NADHm)/(1+exp((delta_psi-p6)/p7))
 
 Assignment Rule (name: NADm) NADm = NADmtot-NADHm
 
 Assignment Rule (name: JPDH) JPDH = p1/(p2+NADHm/NADm)*Cam/(p3+Cam)*(JGPDH+JGPDHbas)
 
 Assignment Rule (name: JHres) JHres = p8*NADHm/(p9+NADHm)*1/(1+exp((delta_psi-p10)/p11))
 
 Assignment Rule (name: JGK_ms) JGK_ms = kappa*JGK
 
 Assignment Rule (name: JHleak) JHleak = p17*delta_psi+p18
 
 Assignment Rule (name: Juni) Juni = (p21*delta_psi-p22)*c^2
 
 Assignment Rule (name: JNaCa) JNaCa = p23*Cam/c*exp(p24*delta_psi)
 
 Assignment Rule (name: Jmito) Jmito = JNaCa-Juni
 
 Assignment Rule (name: ATPm) ATPm = Amtot-ADPm
 
 Assignment Rule (name: JF1F0) JF1F0 = p16*p13/(p13+ATPm)*1/(1+exp((p14-delta_psi)/p15))
 
 Assignment Rule (name: JHatp) JHatp = 3*JF1F0
 
 Assignment Rule (name: RATm) RATm = ATPm/ADPm
 
 Assignment Rule (name: JANT) JANT = p19*RATm/(RATm+p20)*exp(0.5*FRT*delta_psi)
 
 Assignment Rule (name: atp) atp = atot-adp
 
 Assignment Rule (name: atp4m) atp4m = 0.05*atp
 
 Assignment Rule (name: bottomo) bottomo = (1+mgadp/17)^2*(1+adp3m/26+atp4m/1)
 
 Assignment Rule (name: katpo) katpo = topo/bottomo
 
 Assignment Rule (name: Ikatp) Ikatp = gkATP_*katpo*(Vm-VK)
 
 Assignment Rule (name: weight2) weight2 = atp^2/k4
 
 Assignment Rule (name: bottom2) bottom2 = bottom1+weight2
 
 Assignment Rule (name: bottom3) bottom3 = bottom2+weight3
 
 Assignment Rule (name: weight4) weight4 = (F6P*atp)^2/(k3*k4*f43)
 
 Assignment Rule (name: topa4) topa4 = topa3+weight4
 
 Assignment Rule (name: bottom4) bottom4 = bottom3+weight4
 
 Assignment Rule (name: topa5) topa5 = topa4
 
 Assignment Rule (name: bottom5) bottom5 = bottom4+weight5
 
 Assignment Rule (name: weight6) weight6 = FBP*atp^2/(k2*f42*k4)
 
 Assignment Rule (name: topa6) topa6 = topa5
 
 Assignment Rule (name: bottom6) bottom6 = bottom5+weight6
 
 Assignment Rule (name: topa7) topa7 = topa6+weight7
 
 Assignment Rule (name: bottom7) bottom7 = bottom6+weight7
 
 Assignment Rule (name: weight8) weight8 = FBP*F6P^2*atp^2/(k2*f23*f42*f43*k3*k4)
 
 Assignment Rule (name: topa8) topa8 = topa7+weight8
 
 Assignment Rule (name: topa9) topa9 = topa8
 
 Assignment Rule (name: bottom8) bottom8 = bottom7+weight8
 
 Assignment Rule (name: bottom9) bottom9 = bottom8+weight9
 
 Assignment Rule (name: weight10) weight10 = AMP*atp^2/(k1*k4*f41)
 
 Assignment Rule (name: topa10) topa10 = topa9
 
 Assignment Rule (name: bottom10) bottom10 = bottom9+weight10
 
 Assignment Rule (name: topa11) topa11 = topa10+weight11
 
 Assignment Rule (name: bottom11) bottom11 = bottom10+weight11
 
 Assignment Rule (name: weight12) weight12 = AMP*F6P^2*atp^2/(k1*f13*f41*f43*k3*k4)
 
 Assignment Rule (name: topa12) topa12 = topa11+weight12
 
 Assignment Rule (name: bottom12) bottom12 = bottom11+weight12
 
 Assignment Rule (name: topa13) topa13 = topa12
 
 Assignment Rule (name: bottom13) bottom13 = bottom12+weight13
 
 Assignment Rule (name: weight14) weight14 = AMP*FBP*atp^2/(k1*k2*f42*f41*k4)
 
 Assignment Rule (name: topa14) topa14 = topa13
 
 Assignment Rule (name: bottom14) bottom14 = bottom13+weight14
 
 Assignment Rule (name: topa15) topa15 = topa14
 
 Assignment Rule (name: bottom15) bottom15 = bottom14+weight15
 
 Assignment Rule (name: weight16) weight16 = AMP*FBP*F6P^2*atp^2/(k1*k2*k3*k4*f23*f13*f42*f41*f43)
 
 Assignment Rule (name: topa16) topa16 = topa15+weight16
 
 Assignment Rule (name: bottom16) bottom16 = bottom15+weight16
 
 Assignment Rule (name: JPFK) JPFK = (VmaxPFK*lambda*topa16+VmaxPFK*topb)/bottom16
 
 Assignment Rule (name: JPFK_ms) JPFK_ms = kappa*JPFK
 
 Assignment Rule (name: Jhyd) Jhyd = (khyd*c+khydbas)*atp
 
 Assignment Rule (name: Jmem) Jmem = -(alpha*Ica+kPMCA*(c-Cbas))
 
 Assignment Rule (name: Jleak) Jleak = pleak*(Caer-c)
 
 Assignment Rule (name: JSERCA) JSERCA = kSERCA*c
 
 Assignment Rule (name: Jer) Jer = Jleak-JSERCA
 
 Assignment Rule (name: delta) delta = 3.9/53.2
 
 Rate Rule (name: Vm) d [ Vm] / d t= (-(Ik+Ica+Ikca+Ikatp))/cm
 
 Rate Rule (name: n) d [ n] / d t= (n_infinity-n)/tau_n
 
 Rate Rule (name: G6P) d [ G6P] / d t= JGK_ms-JPFK_ms
 
 Rate Rule (name: FBP) d [ FBP] / d t= JPFK_ms-0.5*JGPDH
 
 Rate Rule (name: NADHm) d [ NADHm] / d t= gamma*(JPDH-JO)
 
 Rate Rule (name: delta_psi) d [ delta_psi] / d t= (JHres-(JHatp+JANT+JHleak+JNaCa+2*Juni))/Cmito
 
 Rate Rule (name: Cam) d [ Cam] / d t= (-fmito)*Jmito
 
 Rate Rule (name: ADPm) d [ ADPm] / d t= gamma*(JANT-JF1F0)
 
 Rate Rule (name: adp) d [ adp] / d t= (-delta)*JANT+Jhyd
 
 Rate Rule (name: c) d [ c] / d t= fcyt*(Jmem+Jer+delta*Jmito)
 
 Rate Rule (name: Caer) d [ Caer] / d t= (-fer)*Vc_Ver*Jer
 
   Compartment Spatial dimensions: 3.0  Compartment size: 1.0
 
 Vm
Compartment: Compartment
Initial amount: -60.0
 
 n
Compartment: Compartment
Initial amount: 0.0
 
 G6P
Compartment: Compartment
Initial amount: 301.0
 
 FBP
Compartment: Compartment
Initial amount: 2.16
 
 NADHm
Compartment: Compartment
Initial amount: 0.4
 
 delta_psi
Compartment: Compartment
Initial amount: 164.0
 
 Cam
Compartment: Compartment
Initial amount: 0.2
 
 ADPm
Compartment: Compartment
Initial amount: 11.1
 
 adp
Compartment: Compartment
Initial amount: 1137.0
 
 c
Compartment: Compartment
Initial amount: 0.17
 
 Caer
Compartment: Compartment
Initial amount: 345.0
 
Global Parameters (151)
 
 cm
Value: 5300.0
Constant
 
   Ik  
 
 gK
Value: 2700.0
Constant
 
   n_infinity
Value: 1.50710358059757E-4
 
   tau_n
Value: 20.0
Constant
 
   Ica
Value: -2927.84163162795
 
 gCa
Value: 1000.0
Constant
 
   m_infinity
Value: 0.0344451956662112
 
   Ikca
Value: 466.296163499462
 
 gkCa
Value: 300.0
Constant
 
 kd
Value: 0.5
Constant
 
   Ikatp
Value: 2433.43025793791
 
   gkATP_
Value: 16000.0
Constant
 
   katpo
Value: 0.010139292741408
 
   topo
Value: 110.233638969723
 
   bottomo
Value: 10871.9258612131
 
   mgadp
Value: 187.605
 
   adp3m
Value: 153.495
 
   atp4m
Value: 68.15
 
   JGPDH
Value: 7.34846922834953E-4
 
 kGPDH
Value: 5.0E-4
Constant
 
   F6P
Value: 90.3
 
   JPFK
Value: 0.374364085279846
 
   JPFK_ms
Value: 3.74364085279847E-4
 
 bottom1
Value: 1.0
Constant
 
 weight1
Value: 1.0
Constant
 
 topa1
Constant
 
 k1
Value: 30.0
Constant
 
 k2
Value: 1.0
Constant
 
 k3
Value: 50000.0
Constant
 
 k4
Value: 220.0
Constant
 
 VmaxPFK
Value: 5.0
Constant
 
   weight2
Value: 8444.40454545454
 
   topa2  
 
   bottom2
Value: 8445.40454545454
 
   topa3
Value: 0.1630818
 
   weight3
Value: 0.1630818
 
   bottom3
Value: 8445.56762725454
 
 f13
Value: 0.02
Constant
 
 f43
Value: 20.0
Constant
 
 f23
Value: 0.2
Constant
 
 f42
Value: 20.0
Constant
 
 f41
Value: 20.0
Constant
 
   weight4
Value: 68.8564346600455
 
   topa4
Value: 69.0195164600455
 
   bottom4
Value: 8514.42406191459
 
   weight5
Value: 2.16
 
   topa5
Value: 69.0195164600455
 
   bottom5
Value: 8516.58406191459
 
   weight6
Value: 911.995690909091
 
   topa6
Value: 69.0195164600455
 
   bottom6
Value: 9428.57975282368
 
   weight7
Value: 1.76128344
 
   topa7
Value: 70.7807999000455
 
   bottom7
Value: 9430.34103626368
 
   weight8
Value: 37.1824747164245
 
   topa8
Value: 107.96327461647
 
   bottom8
Value: 9467.52351098011
 
   weight9
Value: 16.6666666666667
 
   topa9
Value: 107.96327461647
 
   bottom9
Value: 9484.19017764677
 
   weight10
Value: 7037.00378787879
 
   topa10
Value: 107.96327461647
 
   bottom10
Value: 16521.1939655256
 
   weight11
Value: 135.9015
 
   topa11
Value: 243.86477461647
 
   bottom11
Value: 16657.0954655256
 
   weight12
Value: 2869.01811083523
 
   topa12
Value: 3112.8828854517
 
   bottom12
Value: 19526.1135763608
 
   weight13
Value: 36.0
 
   topa13
Value: 3112.8828854517
 
   bottom13
Value: 19562.1135763608
 
   weight14
Value: 759.996409090909
 
   topa14
Value: 3112.8828854517
 
   bottom14
Value: 20322.1099854517
 
   weight15
Value: 1467.7362
 
   topa15
Value: 3112.8828854517
 
   bottom15
Value: 21789.8461854517
 
   weight16
Value: 1549.26977985102
 
   topa16
Value: 4662.15266530272
 
   bottom16
Value: 23339.1159653027
 
   topb
Value: 1467.7362
 
 lambda
Value: 0.06
Constant
 
  JPDH
Value: 0.451601160351069
 
 p1
Value: 400.0
Constant
 
 p2
Value: 1.0
Constant
 
 p3
Value: 0.01
Constant
 
 JGPDHbas
Value: 5.0E-4
Constant
 
   JO
Value: 0.446813558235194
 
 p4
Value: 0.6
Constant
 
 p5
Value: 0.1
Constant
 
 p6
Value: 177.0
Constant
 
 p7
Value: 5.0
Constant
 
   NADm
Value: 9.6
 
 NADmtot
Value: 10.0
Constant
 
 Cmito
Value: 1.8
Constant
 
   JHres
Value: 5.21282484607726
 
 p8
Value: 7.0
Constant
 
   p9
Value: 0.1
Constant
 
 p10
Value: 177.0
Constant
 
 p11
Value: 5.0
Constant
 
   JF1F0
Value: 1.12901593707623
 
   p13
Value: 10.0
Constant
 
   p14
Value: 190.0
Constant
 
 p15
Value: 8.5
Constant
 
 p16
Value: 35.0
Constant
 
   JHatp
Value: 3.38704781122868
 
   JGK_ms
Value: 4.0E-4
 
 JGK
Value: 0.4
Constant
 
   JHleak
Value: 0.298
 
 p17
Value: 0.0020
Constant
 
 p18
Value: -0.03
Constant
 
   JANT
Value: 1.1239508472473
 
 p19
Value: 0.35
Constant
 
 p20
Value: 2.0
Constant
 
 FRT
Value: 0.037410133
Constant
 
   RATm
Value: 0.351351351351351
 
   Juni
Value: 0.157794
 
 p21
Value: 0.04
Constant
 
 p22
Value: 1.1
Constant
 
   JNaCa
Value: 0.162244429551387
 
 p23
Value: 0.01
Constant
 
 p24
Value: 0.016
Constant
 
 fmito
Value: 0.01
Constant
 
   Jmito
Value: 0.00445042955138744
 
   ATPm
Value: 3.9
 
 Amtot
Value: 15.0
Constant
 
   Jhyd
Value: 0.0797355
 
 khyd
Value: 5.0E-5
Constant
 
 khydbas
Value: 5.0E-5
Constant
 
   atp
Value: 1363.0
 
 atot
Value: 2500.0
Constant
 
 fcyt
Value: 0.01
Constant
 
   Jmem
Value: 0.00117528734232577
 
 kPMCA
Value: 0.1
Constant
 
 alpha
Value: 4.5E-6
Constant
 
 Cbas
Value: 0.05
Constant
 
   Jleak
Value: 0.068966
 
 pleak
Value: 2.0E-4
Constant
 
   JSERCA
Value: 0.068
 
 kSERCA
Value: 0.4
Constant
 
   Jer
Value: 9.65999999999995E-4
 
 fer
Value: 0.01
Constant
 
 Vc_Ver
Value: 31.0
Constant
 
 gamma
Value: 0.0010
Constant
 
 kappa
Value: 0.0010
Constant
 
   delta
Value: 0.0733082706766917
 
 VK
Value: -75.0
Constant
 
 VCa
Value: 25.0
Constant
 
 AMP
Value: 500.0
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000376

Curator's comment: (updated: 30 Sep 2011 12:49:15 BST)

The model reproduces fig 4 of the reference publication.
The model was integrated and simulated using Copasi v4.7 (Build 34).

Additional file(s)
  • Figure 4:
    This COPASI file reproduces fig 4 of the reference publication,but the time scale needs to be adjusted to get the curation figure
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