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BIOMD0000000369 - Beltrami1995_ThrombinGeneration_D

 

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Reference Publication
Publication ID: 7568009
Beltrami E, Jesty J.
Mathematical analysis of activation thresholds in enzyme-catalyzed positive feedbacks: application to the feedbacks of blood coagulation.
Proc. Natl. Acad. Sci. U.S.A. 1995 Sep; 92(19): 8744-8748
Department of Applied Mathematics and Statistics, State University of New York, Stony Brook 11794, USA.  [more]
Model
Original Model: BIOMD0000000369.xml.origin
Submitter: Michael Schubert
Submission ID: MODEL1108260012
Submission Date: 26 Aug 2011 16:50:02 UTC
Last Modification Date: 20 Apr 2012 20:03:12 UTC
Creation Date: 14 Jun 2011 10:56:31 UTC
Encoders:  Michael Schubert
set #1
bqbiol:is Gene Ontology blood coagulation
set #2
bqbiol:occursIn Taxonomy Eukaryota
Notes

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
For more information see the terms of use .
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 7568009 Submission Date: 26 Aug 2011 16:50:02 UTC Last Modification Date: 20 Apr 2012 20:03:12 UTC Creation Date: 14 Jun 2011 10:56:31 UTC
Mathematical expressions
Rules
Rate Rule (variable: Z1) Rate Rule (variable: Z2) Rate Rule (variable: Z4) Rate Rule (variable: E1)
Rate Rule (variable: E2) Rate Rule (variable: E3) Rate Rule (variable: E4)  
Physical entities
Compartments Species
compartment_1 Z1 Z2 Z4
E1 E2 E3
E4    
Global parameters
mu1 mu2 mu3 mu4
k1 k2 k3 k4
mu5 C    
Reactions (0)
Rules (7)
 
 Rate Rule (name: Z1) d [ Z1] / d t= (-(mu1*E2+mu5*E4))*Z1
 
 Rate Rule (name: Z2) d [ Z2] / d t= (-mu2)*(1+C)*E1*Z2
 
 Rate Rule (name: Z4) d [ Z4] / d t= (-mu4)*E3*Z4
 
 Rate Rule (name: E1) d [ E1] / d t= (mu1*E2+mu5*E4)*Z1-k1*E1
 
 Rate Rule (name: E2) d [ E2] / d t= mu2*E1*Z2-mu3*E4*E2-k2*E2
 
 Rate Rule (name: E3) d [ E3] / d t= mu2*C*E1*Z2+mu3*E4*E2-k3*E3
 
 Rate Rule (name: E4) d [ E4] / d t= mu4*E3*Z4-k4*E4
 
   Spatial dimensions: 3.0  Compartment size: NaN
 
   Z1
Compartment: compartment_1
Initial concentration: 5.0
 
   Z2
Compartment: compartment_1
Initial concentration: 10.0
 
   Z4
Compartment: compartment_1
Initial concentration: 100.0
 
   E1
Compartment: compartment_1
Initial concentration: 0.0
 
   E2
Compartment: compartment_1
Initial concentration: 0.0
 
   E3
Compartment: compartment_1
Initial concentration: 0.0
 
   E4
Compartment: compartment_1
Initial concentration: 0.0
 
Global Parameters (10)
 
   mu1
Value: 1.0
Constant
 
   mu2
Value: 0.1
Constant
 
   mu3
Value: 1.0
Constant
 
   mu4
Value: 1.0
Constant
 
   k1
Value: 1.0
Constant
 
   k2
Value: 1.0
Constant
 
   k3
Value: 1.0
Constant
 
   k4
Value: 1.0
Constant
 
   mu5
Constant
 
   C
Value: 0.0010
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000369

Curator's comment: (updated: 15 Sep 2011 14:46:30 BST)

Reproduction of figure 4 of the article (submodel D)

Integration with Copasi and plotting with Matplotlib.

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