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BIOMD0000000367 - Mueller2008_ThrombinGeneration_minimal

 

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Reference Publication
Publication ID: 17936855
Müller J, Brandt S, Mayerhofer K, Tjardes T, Maegele M.
Tolerance and threshold in the extrinsic coagulation system.
Math Biosci 2008 Feb; 211(2): 226-254
Technical University Munich, Centre for Mathematical Sciences, Boltzmannstr. 3, D-85748 Garching/Munich, Germany. johannes.mueller@gsf.de  [more]
Model
Original Model: BIOMD0000000367.origin
Submitter: Michael Schubert
Submission ID: MODEL1108260013
Submission Date: 26 Aug 2011 16:51:38 UTC
Last Modification Date: 09 Oct 2014 17:24:16 UTC
Creation Date: 16 May 2011 09:49:45 UTC
Encoders:  Michael Schubert
set #1
bqbiol:occursIn Taxonomy Eukaryota
set #2
bqbiol:is Gene Ontology blood coagulation
set #3
bqbiol:hasProperty Human Disease Ontology coronary artery disease
Notes

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
For more information see the terms of use.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 17936855 Submission Date: 26 Aug 2011 16:51:38 UTC Last Modification Date: 09 Oct 2014 17:24:16 UTC Creation Date: 16 May 2011 09:49:45 UTC
Mathematical expressions
Rules
Rate Rule (variable: x) Rate Rule (variable: y) Rate Rule (variable: z) Rate Rule (variable: mu_z)
Physical entities
Compartments Species
compartment_1 x y z
Global parameters
r mu_x zeta b
mu_z epsilon k mu_z_star
Reactions (0)
Rules (4)
 
 Rate Rule (name: x) d [ x] / d t= (-r)*x*y+zeta*mu_x-zeta*x
 
 Rate Rule (name: y) d [ y] / d t= r*x*y-b*y*z-zeta*y
 
 Rate Rule (name: z) d [ z] / d t= (-b)*y*z+zeta*mu_z-zeta*z
 
 Rate Rule (name: mu_z) d [ mu_z] / d t= epsilon*(y-k*(mu_z-mu_z_star))
 
   compartment_1 Spatial dimensions: 3.0  Compartment size: 1.0
 
   x
Compartment: compartment_1
Initial concentration: 4.0
 
   y
Compartment: compartment_1
Initial concentration: 0.2
 
   z
Compartment: compartment_1
Initial concentration: 0.4
 
Global Parameters (8)
 
   r
Value: 0.2
Constant
 
   mu_x
Value: 4.0
Constant
 
   zeta
Value: 0.5
Constant
 
   b
Value: 1.5
Constant
 
   mu_z
Value: 0.4
 
   epsilon
Value: 0.0020
Constant
 
   k
Value: 0.4
Constant
 
   mu_z_star
Value: 0.4
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000367

Curator's comment: (updated: 15 Sep 2011 12:35:42 BST)

Reproduction of figure 5 of the article in one plot: Time course of the complete minimal model with flow and activation of anti-coagulatory substances.

Integrated with Copasi, plotted with Matplotlib.

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