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BIOMD0000000360 - Panteleev2002_TFPImechanism_schmema2

 

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Reference Publication
Publication ID: 11985578
Panteleev MA, Zarnitsina VI, Ataullakhanov FI.
Tissue factor pathway inhibitor: a possible mechanism of action.
Eur. J. Biochem. 2002 Apr; 269(8): 2016-2031
National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, Russia.  [more]
Model
Original Model: BIOMD0000000360.xml.origin
Submitter: Michael Schubert
Submission ID: MODEL1108260007
Submission Date: 26 Aug 2011 16:16:10 UTC
Last Modification Date: 28 May 2014 16:17:16 UTC
Creation Date: 26 Aug 2011 16:36:14 UTC
Encoders:  Michael Schubert
set #1
bqmodel:is Gene Ontology blood coagulation
set #2
bqbiol:occursIn Taxonomy Eukaryota
Notes
Model
Publication ID: 11985578 Submission Date: 26 Aug 2011 16:16:10 UTC Last Modification Date: 28 May 2014 16:17:16 UTC Creation Date: 26 Aug 2011 16:36:14 UTC
Mathematical expressions
Reactions
reaction_1 reaction_2 reaction_3 reaction_4
reaction_5 reaction_6 reaction_7 reaction_8
Physical entities
Compartments Species
compartment VIIa_TF X VIIa_TF_X
VIIa_TF_Xa Xa TFPI
Xa_TFPI Xa_TFPI_VIIa_TF VIIa_TF_Xa_TFPI
Reactions (8)
 
 reaction_1 [X] + [VIIa_TF] ↔ [VIIa_TF_X];  
 
 reaction_2 [VIIa_TF_X] → [VIIa_TF_Xa];  
 
 reaction_3 [VIIa_TF_Xa] ↔ [Xa] + [VIIa_TF];  
 
 reaction_4 [Xa] + [TFPI] ↔ [Xa_TFPI];  
 
 reaction_5 [VIIa_TF] + [Xa_TFPI] ↔ [Xa_TFPI_VIIa_TF];  
 
 reaction_6 [VIIa_TF_Xa] + [TFPI] ↔ [VIIa_TF_Xa_TFPI];  
 
 reaction_7 [VIIa_TF_Xa_TFPI] ↔ [VIIa_TF] + [Xa_TFPI];  
 
 reaction_8 [VIIa_TF_Xa_TFPI] ↔ [Xa_TFPI_VIIa_TF];  
 
   compartment Spatial dimensions: 3.0  Compartment size: 1.0
 
 VIIa_TF
Compartment: compartment
Initial concentration: 0.9999997
 
 X
Compartment: compartment
Initial concentration: 169.9999
 
 VIIa_TF_X
Compartment: compartment
Initial concentration: 0.0
 
 VIIa_TF_Xa
Compartment: compartment
Initial concentration: 0.0
 
 Xa
Compartment: compartment
Initial concentration: 0.0
 
 TFPI
Compartment: compartment
Initial concentration: 2.399999
 
 Xa_TFPI
Compartment: compartment
Initial concentration: 0.0
 
 Xa_TFPI_VIIa_TF
Compartment: compartment
Initial concentration: 0.0
 
 VIIa_TF_Xa_TFPI
Compartment: compartment
Initial concentration: 0.0
 
reaction_1 (2)
 
 k1
Value: 5.0
Constant
 
 k2
Value: 770.0
Constant
 
reaction_2 (1)
 
 k1
Value: 420.0
Constant
 
reaction_3 (2)
 
 k1
Value: 770.0
Constant
 
 k2
Value: 5.0
Constant
 
reaction_4 (2)
 
 k1
Value: 0.054
Constant
 
 k2
Value: 0.02
Constant
 
reaction_5 (2)
 
 k1
Value: 0.44
Constant
 
 k2
Value: 0.066
Constant
 
reaction_6 (2)
 
 k1
Value: 10.0
Constant
 
 k2
Constant
 
reaction_7 (2)
 
 k1
Constant
 
 k2
Constant
 
reaction_8 (2)
 
 k1
Constant
 
 k2
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000360

Curator's comment: (updated: 26 Aug 2011 17:25:18 BST)

Reproduction of figure 2a of the article.

Model integrated using PySCeS and plotted with Matplotlib.

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