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BIOMD0000000357 - Lee2010_ThrombinActivation_OneForm_reduced

 

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Reference Publication
Publication ID: 20435402
Lee CJ, Wu S, Eun C, Pedersen LG.
A revisit to the one form kinetic model of prothrombinase.
Biophys. Chem. 2010 Jun; 149(1-2): 28-33
Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599-3290, USA.  [more]
Model
Original Model: BIOMD0000000357.origin
Submitter: Michael Schubert
Submission ID: MODEL1108260003
Submission Date: 26 Aug 2011 16:13:48 UTC
Last Modification Date: 09 Oct 2014 16:58:21 UTC
Creation Date: 26 Aug 2011 16:35:05 UTC
Encoders:  Michael Schubert
set #1
bqmodel:isDerivedFrom PubMed 17726029
set #2
bqbiol:isVersionOf Gene Ontology obsolete coagulation factor Xa activity
Gene Ontology blood coagulation
bqbiol:hasTaxon Taxonomy Eukaryota
Notes
Model
Publication ID: 20435402 Submission Date: 26 Aug 2011 16:13:48 UTC Last Modification Date: 09 Oct 2014 16:58:21 UTC Creation Date: 26 Aug 2011 16:35:05 UTC
Mathematical expressions
Reactions
r1 r2 r5 r7
r8 r9 r12 r14
Physical entities
Compartments Species
compartment E E_P_1 P
M E_M T
E_P_2 P2 E_P2
Global parameters
k1 k2 k3a k4a
k5 k6 k7a k8a
j1 j3a j5 j7a
Reactions (8)
 
 r1 [E] + [P] ↔ [E_P_1];  
 
 r2 [E_P_1] → [E] + [M];  
 
 r5 [E] + [M] ↔ [E_M];  
 
 r7 [E_M] → [E] + [T];  
 
 r8 [E] + [P] ↔ [E_P_2];  
 
 r9 [E_P_2] → [E] + [P2];  
 
 r12 [E] + [P2] ↔ [E_P2];  
 
 r14 [E_P2] → [E] + [T];  
 
   compartment Spatial dimensions: 3.0  Compartment size: 1.0
 
 E
Compartment: compartment
Initial concentration: 1.5E-4
 
 E_P_1
Compartment: compartment
Initial concentration: 0.0
 
 P
Compartment: compartment
Initial concentration: 1.0
 
 M
Compartment: compartment
Initial concentration: 0.0
 
 E_M
Compartment: compartment
Initial concentration: 0.0
 
 T
Compartment: compartment
Initial concentration: 0.0
 
 E_P_2
Compartment: compartment
Initial concentration: 0.0
 
 P2
Compartment: compartment
Initial concentration: 0.0
 
 E_P2
Compartment: compartment
Initial concentration: 0.0
 
Global Parameters (12)
 
 k1
Value: 91.8
Constant
 
 k2
Value: 82.4
Constant
 
 k3a
Value: 151.5
Constant
 
 k4a
Value: 209.9
Constant
 
 k5
Value: 5.16
Constant
 
 k6
Value: 32.3
Constant
 
 k7a
Value: 4.7
Constant
 
 k8a
Value: 42.6
Constant
 
 j1
Value: 33.4
Constant
 
 j3a
Value: 0.185
Constant
 
 j5
Value: 21.8
Constant
 
 j7a
Value: 2.66E-5
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000357

Curator's comment: (updated: 26 Aug 2011 17:31:24 BST)

Reproduction of figure S6 of the supplementary material.

Model integrated using PySCeS and plotted with Matplotlib.

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