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BIOMD0000000340 - Wajima2009_BloodCoagulation_warfarin_heparin

 

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Reference Publication
Publication ID: 19516255
Wajima T, Isbister GK, Duffull SB.
A comprehensive model for the humoral coagulation network in humans.
Clin. Pharmacol. Ther. 2009 Sep; 86(3): 290-298
School of Pharmacy, University of Otago, Dunedin, New Zealand.  [more]
Model
Original Model: BIOMD0000000340.xml.origin
Submitter: Michael Schubert
Submission ID: MODEL1107010002
Submission Date: 01 Jul 2011 14:29:08 UTC
Last Modification Date: 28 May 2014 15:34:26 UTC
Creation Date: 05 Jul 2011 17:07:40 UTC
Encoders:  Vijayalakshmi Chelliah
   Michael Schubert
set #1
bqmodel:isDerivedFrom BioModels Database Kogan2001_aPTT_coagulation
BioModels Database Kogan2001_aPTT_preincubation
BioModels Database Qiao2004_ThrombinGeneration
BioModels Database Hockin1999_BloodCoagulation_VaInactivation
PubMed 18831981
PubMed 12524220
PubMed 2779263
PubMed 8948060
PubMed 12231555
PubMed 15804855
PubMed 16432308
PubMed 7843644
PubMed 9645916
set #2
bqbiol:hasTaxon Taxonomy Homo sapiens
set #3
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
set #4
bqbiol:hasVersion Human Disease Ontology DOID:12259
set #5
bqbiol:encodes Gene Ontology regulation of blood coagulation
Notes

This model is from the article:
A comprehensive model for the humoral coagulation network in humans.
Wajima T, Isbister GK, Duffull SB. Clinical Pharmacology and therapeuticsVolume 86, Issue 3, 10 June 2009, EPub 19516255,
Abstract:
Coagulation is an important process in hemostasis and comprises a complicated interaction of multiple enzymes and proteins. We have developed a mechanistic quantitative model of the coagulation network. The model accurately describes the time courses of coagulation factors following in vivo activation as well as in vitro blood coagulation tests of prothrombin time (PT, often reported as international normalized ratio (INR)) and activated partial thromboplastin time (aPTT). The model predicts the concentration-time and time-effect profiles of warfarin, heparins, and vitamin K in humans. The model can be applied to predict the time courses of coagulation kinetics in clinical situations (e.g., hemophilia) and for biomarker identification during drug development. The model developed in this study is the first quantitative description of the comprehensive coagulation network.

Model
Publication ID: 19516255 Submission Date: 01 Jul 2011 14:29:08 UTC Last Modification Date: 28 May 2014 15:34:26 UTC Creation Date: 05 Jul 2011 17:07:40 UTC
Mathematical expressions
Reactions
r1 r2 r3 r4
r5 r6 r7 r8
r9 r10 r11 r12
r13 r14 r15 r16
r17 r18 r19 r20
r21 r22 r23 r24
r25 r26 r27 r28
r29 r30 r31 r32
r33 r34 r35 r36
r37 r38 r39 r40
r41 r42 r43 r44
r45 r46 r47 r48
pII_VKH2 pVII_VKH2 pIX_VKH2 pX_VKH2
pPC_VKH2 pPS_VKH2 dFg dF
dXF dII dIIa dTF
dV dVa dVII dVIIa
dVIII dVIIIa dX dXa
dIX dIXa dXII dXIIa
dXIII dXIIIa dPk dK
dPg dP dPC dAPC
dPS dFDP dD dTFPI
dVIIa_TF dVII_TF dAPC_PS dVa_Xa
dIXa_VIIIa dTmod dIIa_Tmod dXa_TFPI
dVIIa_TF_Xa_TFPI dTAT dCA dXIa
dVKH2 VK_transport eHeparin eHeparinXa
eHeparinIXa eHeparinIIa dXI pXII
pVIII pXI pV pFg
pXIII pPg pTmod pTFPI
pPk pVK dVK pHeparin
Rules
Assignment Rule (variable: DP) Rate Rule (variable: C_warf) Rate Rule (variable: A_warf)  
Events
warfarin_administration heparin_administration    
Physical entities
Compartments Species
compartment_1 IIa VIII VIIIa
APC_PS IX IXa
XIa XI XIIa
VII VIIa X
Xa IXa_VIIIa V
Va II F
Fg DP P
XF XIII Pg
APC IIa_Tmod PC
Tmod TF VIIa_TF
VII_TF Xa_TFPI TFPI
PS VKH2 Va_Xa
CA XII K
ATIII_Heparin Xa_ATIII_Heparin VK
C_warf VKO Pk
FDP D TAT
VIIa_TF_Xa_TFPI XIIIa IIa_ATIII_Heparin
IXa_ATIII_Heparin A_warf VK_p
Global parameters
I_max IC50 II(0) VII(0)
IX(0) X(0) PC(0) PS(0)
VKH2(0) d_II d_VII d_IX
d_X d_PC d_PS vitaminK_Vc
d_VK2 d_VKH2 d_VKO VK(0)
VKO(0) vitaminK_k21/Vc vitaminK_k12 heparin_ke
warfarin_ka warfarin_Vd warfarin_CL warfarin_ke
d_XII d_VIII d_XI d_V
d_Fg d_XIII d_Pg d_Tmod
d_TFPI d_Pk XII(0) VIII(0)
XI(0) V(0) Fg(0) XIII(0)
Pg(0) Tmod(0) TFPI(0) Pk(0)
R1 R2 c44 c45
c46 d_VK warfarin_daily_dose heparin_infusion
heparin_bolus heparin_infusion_duration [hr]    
Reactions (116)
 
 r1 [VIII] → [VIIIa];   {IIa}
 
 r2 [VIIIa] → ;   {APC_PS}
 
 r3 [IX] → [IXa];   {XIa}
 
 r4 [XI] → [XIa];   {XIIa}
 
 r5 [XI] → [XIa];   {IIa}
 
 r6 [VII] → [VIIa];   {IIa}
 
 r7 [X] → [Xa];   {IXa}
 
 r8 [X] → [Xa];   {IXa_VIIIa}
 
 r9 [X] → [Xa];   {VIIa}
 
 r10 [V] → [Va];   {IIa}
 
 r11 [Va] → ;   {APC_PS}
 
 r12 [II] → [IIa];   {Va_Xa}
 
 r13 [II] → [IIa];   {Xa}
 
 r14 [Fg] → [F];   {IIa}
 
 r15 [Fg] → [FDP];   {P}
 
 r16 [F] → [XF];   {XIIIa}
 
 r17 [F] → [FDP];   {P}
 
 r18 [XF] → [D];   {P}
 
 r19 [XF] → [D];   {APC_PS}
 
 r20 [XIII] → [XIIIa];   {IIa}
 
 r21 [Pg] → [P];   {IIa}
 
 r22 [Pg] → [P];   {F}
 
 r23 [Pg] → [P];   {APC_PS}
 
 r24 [PC] → [APC];   {IIa_Tmod}
 
 r25 [Va_Xa] → ;   {APC_PS}
 
 r26 [IXa] + [VIIIa] → [IXa_VIIIa];  
 
 r27 [Va] + [Xa] → [Va_Xa];  
 
 r28 [IIa] + [Tmod] → [IIa_Tmod];  
 
 r29 [VIIa] + [TF] → [VIIa_TF];  
 
 r30 [VII] + [TF] → [VII_TF];  
 
 r31 [VIIa_TF] + [Xa_TFPI] → [VIIa_TF_Xa_TFPI];  
 
 r32 [Xa] + [TFPI] → [Xa_TFPI];  
 
 r33 [VII_TF] → [VIIa_TF];   {Xa}
 
 r34 [X] → [Xa];   {VIIa_TF}
 
 r35 [IX] → [IXa];   {VIIa_TF}
 
 r36 [VII_TF] → [VIIa_TF];   {TF}
 
 r37 [APC] + [PS] → [APC_PS];  
 
 r38 [VII] → [VIIa];   {Xa}
 
 r39 [VII] → [VIIa];   {VIIa_TF}
 
 r40 [VII] → [VIIa];   {IXa}
 
 r41 [XII] → [XIIa];   {CA}
 
 r42 [XII] → [XIIa];   {K}
 
 r43 [Pk] → [K];   {XIIa}
 
 r44 [IIa] + [ATIII_Heparin] → [IIa_ATIII_Heparin];  
 
 r45 [Xa] + [ATIII_Heparin] → [Xa_ATIII_Heparin];  
 
 r46 [IXa] + [ATIII_Heparin] → [IXa_ATIII_Heparin];  
 
 r47 [VK] → [VKH2];   {C_warf}
 
 r48 [VKO] → [VK];   {C_warf}
 
 pII_VKH2  → [II];   {VKH2}
 
 pVII_VKH2  → [VII];   {VKH2}
 
 pIX_VKH2  → [IX];   {VKH2}
 
 pX_VKH2  → [X];   {VKH2}
 
 pPC_VKH2  → [PC];   {VKH2}
 
 pPS_VKH2  → [PS];   {VKH2}
 
 dFg [Fg] → [FDP];  
 
 dF [F] → [FDP];  
 
 dXF [XF] → [D];  
 
 dII [II] → ;  
 
 dIIa [IIa] → [TAT];  
 
 dTF [TF] → ;  
 
 dV [V] → ;  
 
 dVa [Va] → ;  
 
 dVII [VII] → ;  
 
 dVIIa [VIIa] → ;  
 
 dVIII [VIII] → ;  
 
 dVIIIa [VIIIa] → ;  
 
 dX [X] → ;  
 
 dXa [Xa] → ;  
 
 dIX [IX] → ;  
 
 dIXa [IXa] → ;  
 
 dXII [XII] → ;  
 
 dXIIa [XIIa] → ;  
 
 dXIII [XIII] → ;  
 
 dXIIIa [XIIIa] → ;  
 
 dPk [Pk] → ;  
 
 dK [K] → ;  
 
 dPg [Pg] → ;  
 
 dP [P] → ;  
 
 dPC [PC] → ;  
 
 dAPC [APC] → ;  
 
 dPS [PS] → ;  
 
 dFDP [FDP] → ;  
 
 dD [D] → ;  
 
 dTFPI [TFPI] → ;  
 
 dVIIa_TF [VIIa_TF] → ;  
 
 dVII_TF [VII_TF] → ;  
 
 dAPC_PS [APC_PS] → ;  
 
 dVa_Xa [Va_Xa] → ;  
 
 dIXa_VIIIa [IXa_VIIIa] → ;  
 
 dTmod [Tmod] → ;  
 
 dIIa_Tmod [IIa_Tmod] → ;  
 
 dXa_TFPI [Xa_TFPI] → ;  
 
 dVIIa_TF_Xa_TFPI [VIIa_TF_Xa_TFPI] → ;  
 
 dTAT [TAT] → ;  
 
 dCA [CA] → ;  
 
 dXIa [XIa] → ;  
 
 dVKH2 [VKH2] → [VKO];  
 
 VK_transport [VK] ↔ [VK_p];  
 
 eHeparin [ATIII_Heparin] → ;  
 
 eHeparinXa [Xa_ATIII_Heparin] → ;  
 
 eHeparinIXa [IXa_ATIII_Heparin] → ;  
 
 eHeparinIIa [IIa_ATIII_Heparin] → ;  
 
 dXI [XI] → ;  
 
 pXII  → [XII];  
 
 pVIII  → [VIII];  
 
 pXI  → [XI];  
 
 pV  → [V];  
 
 pFg  → [Fg];  
 
 pXIII  → [XIII];  
 
 pPg  → [Pg];  
 
 pTmod  → [Tmod];  
 
 pTFPI  → [TFPI];  
 
 pPk  → [Pk];  
 
 pVK  → [VK];  
 
 dVK [VK] → ;  
 
 pHeparin  → [ATIII_Heparin];  
 
Rules (3)
 
 Assignment Rule (name: DP) DP = FDP+D
 
 Rate Rule (name: C_warf) d [ C_warf] / d t= warfarin_ka*A_warf/warfarin_Vd-warfarin_ke*C_warf
 
 Rate Rule (name: A_warf) d [ A_warf] / d t= (-warfarin_ka)*A_warf
 
Events (2)
 
 warfarin_administration
A_warf = A_warf+warfarin_daily_dose
 
 heparin_administration
heparin_infusion = 0
 
Functions (6)
 
 Constant flux (irreversible) lambda(v, v)
 
 Factor production lambda(initial, degradation, initial*degradation)
 
 Hyperbolic rate law lambda(v, substrate, enzyme, k, v*substrate*enzyme/(k+enzyme))
 
 VKH2-mediated factor production lambda(d_factor, factor_initial, VKH2, VKH2_initial, d_factor*factor_initial*VKH2/VKH2_initial)
 
 Irreversible association lambda(s1, s2, c, s1*s2/c)
 
 Warfarin inhibited first order kinetics lambda(Imax, Cwarf, IC50, substrate, degradation, degradation*substrate*(1-Imax*Cwarf/(IC50+Cwarf)))
 
   compartment_1 Spatial dimensions: 3.0  Compartment size: 1.0
 
 IIa
Compartment: compartment_1
Initial concentration: 0.0
 
 VIII
Compartment: compartment_1
Initial concentration: 0.7
 
 VIIIa
Compartment: compartment_1
Initial concentration: 0.0
 
 APC_PS
Compartment: compartment_1
Initial concentration: 0.0
 
 IX
Compartment: compartment_1
Initial concentration: 89.6
 
 IXa
Compartment: compartment_1
Initial concentration: 0.0
 
 XIa
Compartment: compartment_1
Initial concentration: 0.0
 
 XI
Compartment: compartment_1
Initial concentration: 30.6
 
 XIIa
Compartment: compartment_1
Initial concentration: 0.0
 
 VII
Compartment: compartment_1
Initial concentration: 10.0
 
 VIIa
Compartment: compartment_1
Initial concentration: 0.0
 
 X
Compartment: compartment_1
Initial concentration: 174.3
 
 Xa
Compartment: compartment_1
Initial concentration: 0.0
 
 IXa_VIIIa
Compartment: compartment_1
Initial concentration: 0.0
 
 V
Compartment: compartment_1
Initial concentration: 26.7
 
 Va
Compartment: compartment_1
Initial concentration: 0.0
 
 II
Compartment: compartment_1
Initial concentration: 1394.4
 
 F
Compartment: compartment_1
Initial concentration: 0.0
 
 Fg
Compartment: compartment_1
Initial concentration: 8945.5
 
   DP
Compartment: compartment_1
Initial concentration: 0.0
 
 P
Compartment: compartment_1
Initial concentration: 0.0
 
 XF
Compartment: compartment_1
Initial concentration: 0.0
 
 XIII
Compartment: compartment_1
Initial concentration: 70.3
 
 Pg
Compartment: compartment_1
Initial concentration: 2154.3
 
 APC
Compartment: compartment_1
Initial concentration: 0.0
 
 IIa_Tmod
Compartment: compartment_1
Initial concentration: 0.0
 
 PC
Compartment: compartment_1
Initial concentration: 60.0
 
 Tmod
Compartment: compartment_1
Initial concentration: 50.0
 
 TF
Compartment: compartment_1
Initial concentration: 0.0
 
 VIIa_TF
Compartment: compartment_1
Initial concentration: 0.0
 
 VII_TF
Compartment: compartment_1
Initial concentration: 0.0
 
 Xa_TFPI
Compartment: compartment_1
Initial concentration: 0.0
 
 TFPI
Compartment: compartment_1
Initial concentration: 2.5
 
 PS
Compartment: compartment_1
Initial concentration: 300.0
 
 VKH2
Compartment: compartment_1
Initial concentration: 0.1
 
 Va_Xa
Compartment: compartment_1
Initial concentration: 0.0
 
   CA
Compartment: compartment_1
Initial concentration: 0.0
 
 XII
Compartment: compartment_1
Initial concentration: 375.0
 
 K
Compartment: compartment_1
Initial concentration: 0.0
 
 ATIII_Heparin
Compartment: compartment_1
Initial concentration: 0.0
 
 Xa_ATIII_Heparin
Compartment: compartment_1
Initial concentration: 0.0
 
 VK
Compartment: compartment_1
Initial concentration: 1.0
 
 C_warf
Compartment: compartment_1
Initial concentration: 0.0
 
 VKO
Compartment: compartment_1
Initial concentration: 0.1
 
 Pk
Compartment: compartment_1
Initial concentration: 450.0
 
 FDP
Compartment: compartment_1
Initial concentration: 0.0
 
   D
Compartment: compartment_1
Initial concentration: 0.0
 
 TAT
Compartment: compartment_1
Initial concentration: 0.0
 
 VIIa_TF_Xa_TFPI
Compartment: compartment_1
Initial concentration: 0.0
 
 XIIIa
Compartment: compartment_1
Initial concentration: 0.0
 
 IIa_ATIII_Heparin
Compartment: compartment_1
Initial concentration: 0.0
 
 IXa_ATIII_Heparin
Compartment: compartment_1
Initial concentration: 0.0
 
 A_warf
Compartment: compartment_1
Initial concentration: 0.0
 
 VK_p
Compartment: compartment_1
Initial concentration: 115.4754
 
Global Parameters (58)
 
   I_max
Value: 1.0
Constant
 
   IC50
Value: 0.34
Constant
 
   II(0)
Value: 1394.4
Constant
 
   VII(0)
Value: 10.0
Constant
 
   IX(0)
Value: 89.6
Constant
 
   X(0)
Value: 174.3
Constant
 
   PC(0)
Value: 60.0
Constant
 
   PS(0)
Value: 300.0
Constant
 
   VKH2(0)
Value: 0.1
Constant
 
 d_II
Value: 0.01
Constant
 
 d_VII
Value: 0.12
Constant
 
 d_IX
Value: 0.029
Constant
 
 d_X
Value: 0.018
Constant
 
 d_PC
Value: 0.05
Constant
 
 d_PS
Value: 0.0165
Constant
 
   vitaminK_Vc
Value: 24.0
Constant
 
   d_VK2
Value: 0.0228
Constant
 
 d_VKH2
Value: 0.228
Constant
 
   d_VKO
Value: 0.228
Constant
 
   VK(0)
Value: 1.0
Constant
 
   VKO(0)
Value: 0.1
Constant
 
 vitaminK_k21/Vc
Value: 5.08333333333333E-4
Constant
 
 vitaminK_k12
Value: 0.0587
Constant
 
 heparin_ke
Value: 0.693
Constant
 
   warfarin_ka
Value: 1.0
Constant
 
   warfarin_Vd
Value: 10.0
Constant
 
   warfarin_CL
Value: 0.2
Constant
 
   warfarin_ke
Value: 0.02
Constant
 
 d_XII
Value: 0.012
Constant
 
 d_VIII
Value: 0.058
Constant
 
   d_XI
Value: 0.1
Constant
 
 d_V
Value: 0.043
Constant
 
 d_Fg
Value: 0.032
Constant
 
 d_XIII
Value: 0.0036
Constant
 
 d_Pg
Value: 0.05
Constant
 
 d_Tmod
Value: 0.05
Constant
 
 d_TFPI
Value: 20.0
Constant
 
 d_Pk
Value: 0.05
Constant
 
   XII(0)
Value: 375.0
Constant
 
   VIII(0)
Value: 0.7
Constant
 
   XI(0)
Value: 30.6
Constant
 
   V(0)
Value: 26.7
Constant
 
   Fg(0)
Value: 8945.5
Constant
 
   XIII(0)
Value: 70.3
Constant
 
   Pg(0)
Value: 2154.3
Constant
 
   Tmod(0)
Value: 50.0
Constant
 
   TFPI(0)
Value: 2.5
Constant
 
   Pk(0)
Value: 450.0
Constant
 
   R1
Value: 0.140845070422535
Constant
 
   R2
Value: 1.0
Constant
 
 c44
Value: 0.119718309859155
Constant
 
 c45
Value: 0.85
Constant
 
 c46
Value: 0.85
Constant
 
 d_VK
Value: 0.2052
Constant
 
   warfarin_daily_dose
Value: 4.0
Constant
 
 heparin_infusion  
 
   heparin_bolus
Constant
 
   heparin_infusion_duration [hr]
Value: 24.0
Constant
 
r1 (2)
 
 v
Value: 50000.0
Constant
 
 k
Value: 1.0E-6
Constant
 
r2 (2)
 
 v
Value: 50.0
Constant
 
 k
Value: 1.0
Constant
 
r3 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 10.0
Constant
 
r4 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 1.0
Constant
 
r5 (2)
 
 v
Value: 10.0
Constant
 
 k
Value: 10.0
Constant
 
r6 (2)
 
 v
Value: 0.1
Constant
 
 k
Value: 10.0
Constant
 
r7 (2)
 
 v
Value: 0.02
Constant
 
 k
Value: 10.0
Constant
 
r8 (2)
 
 v
Value: 2.0
Constant
 
 k
Value: 0.1
Constant
 
r9 (2)
 
 v
Value: 1.0E-9
Constant
 
 k
Value: 10.0
Constant
 
r10 (2)
 
 v
Value: 50000.0
Constant
 
 k
Value: 10.0
Constant
 
r11 (2)
 
 v
Value: 50.0
Constant
 
 k
Value: 1.0
Constant
 
r12 (2)
 
 v
Value: 100.0
Constant
 
 k
Value: 10.0
Constant
 
r13 (2)
 
 v
Value: 9.0
Constant
 
 k
Value: 500.0
Constant
 
r14 (2)
 
 v
Value: 20000.0
Constant
 
 k
Value: 0.5
Constant
 
r15 (2)
 
 v
Value: 500.0
Constant
 
 k
Value: 500.0
Constant
 
r16 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 10.0
Constant
 
r17 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 10.0
Constant
 
r18 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 100.0
Constant
 
r19 (2)
 
 v
Value: 1.0
Constant
 
 k
Value: 1.0
Constant
 
r20 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 1.0
Constant
 
r21 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 5000.0
Constant
 
r22 (2)
 
 v
Value: 5.0
Constant
 
 k
Value: 10000.0
Constant
 
r23 (2)
 
 v
Value: 2.0
Constant
 
 k
Value: 1.0
Constant
 
r24 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 1.0
Constant
 
r25 (2)
 
 v
Value: 2.0
Constant
 
 k
Value: 1.0
Constant
 
r26 (1)
 
 c
Value: 0.01
Constant
 
r27 (1)
 
 c
Value: 0.5
Constant
 
r28 (1)
 
 c
Value: 0.5
Constant
 
r29 (1)
 
 c
Value: 0.5
Constant
 
r30 (1)
 
 c
Value: 0.1
Constant
 
r31 (1)
 
 c
Value: 0.5
Constant
 
r32 (1)
 
 c
Value: 0.5
Constant
 
r33 (2)
 
 v
Value: 70.0
Constant
 
 k
Value: 1.0
Constant
 
r34 (2)
 
 v
Value: 900.0
Constant
 
 k
Value: 200.0
Constant
 
r35 (2)
 
 v
Value: 70.0
Constant
 
 k
Value: 1.0
Constant
 
r36 (2)
 
 v
Value: 1000.0
Constant
 
 k
Value: 1.0
Constant
 
r37 (1)
 
 c
Value: 0.5
Constant
 
r38 (2)
 
 v
Value: 1.0
Constant
 
 k
Value: 10.0
Constant
 
r39 (2)
 
 v
Value: 1.0
Constant
 
 k
Value: 10.0
Constant
 
r40 (2)
 
 v
Value: 0.2
Constant
 
 k
Value: 10.0
Constant
 
r41 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 1.0
Constant
 
r42 (2)
 
 v
Value: 70.0
Constant
 
 k
Value: 1.0
Constant
 
r43 (2)
 
 v
Value: 7.0
Constant
 
 k
Value: 1.0
Constant
 
dF (1)
 
 k1
Value: 0.05
Constant
 
dXF (1)
 
 k1
Value: 0.05
Constant
 
dIIa (1)
 
 k1
Value: 67.4
Constant
 
dTF (1)
 
 k1
Value: 0.05
Constant
 
dVa (1)
 
 k1
Value: 20.0
Constant
 
dVIIa (1)
 
 k1
Value: 20.0
Constant
 
dVIIIa (1)
 
 k1
Value: 20.0
Constant
 
dXa (1)
 
 k1
Value: 20.0
Constant
 
dIXa (1)
 
 k1
Value: 20.0
Constant
 
dXIIa (1)
 
 k1
Value: 20.0
Constant
 
dXIIIa (1)
 
 k1
Value: 0.69
Constant
 
dK (1)
 
 k1
Value: 20.0
Constant
 
dP (1)
 
 k1
Value: 20.0
Constant
 
dAPC (1)
 
 k1
Value: 20.4
Constant
 
dFDP (1)
 
 k1
Value: 3.5
Constant
 
dD (1)
 
 k1
Value: 0.1
Constant
 
dVIIa_TF (1)
 
 k1
Value: 20.0
Constant
 
dVII_TF (1)
 
 k1
Value: 0.7
Constant
 
dAPC_PS (1)
 
 k1
Value: 20.0
Constant
 
dVa_Xa (1)
 
 k1
Value: 20.0
Constant
 
dIXa_VIIIa (1)
 
 k1
Value: 20.0
Constant
 
dIIa_Tmod (1)
 
 k1
Value: 20.0
Constant
 
dXa_TFPI (1)
 
 k1
Value: 20.0
Constant
 
dVIIa_TF_Xa_TFPI (1)
 
 k1
Value: 20.0
Constant
 
dTAT (1)
 
 k1
Value: 0.2
Constant
 
dCA (1)
 
 k1
Value: 0.05
Constant
 
dXIa (1)
 
 k1
Value: 20.0
Constant
 
dXI (1)
 
 k1
Value: 0.1
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000340

Curator's comment: (updated: 05 Jul 2011 18:05:54 BST)

Simulated warfarin plasma concentration after administration of 4 mg daily over the course of 20 days (left) and its effect on the plasma concentrations of vitamin K-related compounds (middle) and factors (right). The latter two are represented as fraction of their untreated steady state concentrations.

Simulated using Copasi and plotted with Matplotlib.

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