Try the new BioModels platform (beta)
BioModels Database logo

BioModels Database

spacer

BIOMD0000000256 - Rehm2006_Caspase

 

 |   |   |  Send feedback
Reference Publication
Publication ID: 16932741
Rehm M, Huber HJ, Dussmann H, Prehn JH.
Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein.
EMBO J. 2006 Sep; 25(18): 4338-4349
Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.  [more]
Model
Original Model: BIOMD0000000256.origin
Submitter: G Gomez Estrada
Submission ID: MODEL5073396359
Submission Date: 12 Sep 2007 08:39:01 UTC
Last Modification Date: 08 Apr 2016 16:16:28 UTC
Creation Date: 30 Jul 2010 15:23:23 UTC
Encoders:  Lukas Endler
set #1
bqbiol:isVersionOf Gene Ontology apoptotic process
Gene Ontology activation of cysteine-type endopeptidase activity involved in apoptotic process
bqbiol:hasTaxon Taxonomy Homo sapiens
bqbiol:occursIn Brenda Tissue Ontology BTO:0000567
Notes

This is the standard model described in the article:
Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein.
Rehm M, Huber HJ, Dussmann H, Prehn JH. EMBO J. 2006 Sep 20;25(18):4338-49. Epub 2006 Aug 24. PMID:16932741, doi:10.1038/sj.emboj.7601295;
Abstract:
Activation of effector caspases is a final step during apoptosis. Single-cell imaging studies have demonstrated that this process may occur as a rapid, all-or-none response, triggering a complete substrate cleavage within 15 min. Based on biochemical data from HeLa cells, we have developed a computational model of apoptosome-dependent caspase activation that was sufficient to remodel the rapid kinetics of effector caspase activation observed in vivo. Sensitivity analyses predicted a critical role for caspase-3-dependent feedback signalling and the X-linked-inhibitor-of-apoptosis-protein (XIAP), but a less prominent role for the XIAP antagonist Smac. Single-cell experiments employing a caspase fluorescence resonance energy transfer substrate verified these model predictions qualitatively and quantitatively. XIAP was predicted to control this all-or-none response, with concentrations as high as 0.15 microM enabling, but concentrations >0.30 microM significantly blocking substrate cleavage. Overexpression of XIAP within these threshold concentrations produced cells showing slow effector caspase activation and submaximal substrate cleavage. Our study supports the hypothesis that high levels of XIAP control caspase activation and substrate cleavage, and may promote apoptosis resistance and sublethal caspase activation in vivo.

This model is slightly altered from the description in the article. Cytochrome C and SMAC release from the mitochondrion is modelled as simple first order kinetics, giving the same form as the (integrated) equations in the supplement of the article. The apoptosome formation is modelled equally - and independent of the Cytochrome C release. The speed is either limited by the Apaf1 or ProCaspase9 concentration, whichever is higher, symbolised via the parameter with the ID apolim.
Also, once the substrate concentration falls below 1 percent, the event Production_Breakdown is triggered, leading to a breakdown of XIAP and procaspase3 production and turning off of the enhanced/proteosomal degradation (degradation rate for reactions 38,39,40,43,44,46,48,50,51 changes from 0.0347 to 0.0058).

Originally created by libAntimony v1.3 (using libSBML 3.4.1)

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2012 The BioModels.net Team.
For more information see the terms of use.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 16932741 Submission Date: 12 Sep 2007 08:39:01 UTC Last Modification Date: 08 Apr 2016 16:16:28 UTC Creation Date: 30 Jul 2010 15:23:23 UTC
Mathematical expressions
Reactions
ProCaspase3 Production XIAP Production reaction3 reaction4
reaction5 reaction6 reaction7 reaction8
reaction9 reaction10 reaction11 reaction12
reaction13 reaction14 reaction15 reaction16
reaction17 reaction18 reaction19 reaction20
reaction21 reaction22 reaction23 reaction24
reaction25 reaction26 reaction27 reaction28
reaction29 reaction30 reaction31 reaction32
reaction33 reaction34 reaction35 reaction36
reaction37 reaction38 reaction39 reaction40
reaction41 reaction42 reaction43 reaction44
reaction45 reaction46 reaction47 reaction48
reaction49 reaction50 reaction51 reaction52
reaction53 SMAC_release Apo_formation CytC_release
Rules
Assignment Rule (variable: limiting factor for apoptosome formation) Assignment Rule (variable: free SMAC per XIAP) Assignment Rule (variable: XIAP2*SMAC per XIAP) Assignment Rule (variable: normalised Casp-9)
Assignment Rule (variable: normalised Casp9-P) Assignment Rule (variable: normalised Casp-3) Assignment Rule (variable: normalised Procasp-3) Assignment Rule (variable: percent SMAC release)
Assignment Rule (variable: percent Apoptosome formation) Assignment Rule (variable: XIAP_norm) Assignment Rule (variable: XIAP_C3_norm) Assignment Rule (variable: XIAP_C9_norm)
Assignment Rule (variable: XIAP_p2frag_norm) Assignment Rule (variable: BIR12_norm) Assignment Rule (variable: BIR3R_norm) Assignment Rule (variable: BIR12_C3_norm)
Assignment Rule (variable: BIR3R_C9_norm) Assignment Rule (variable: BIR3R_p2frag_norm)    
Events
Production_Breakdown      
Physical entities
Compartments Species
cell ProCasp3 XIAP Casp9(p35-p12)
ProCasp9 C3 Casp9(p35-p10)
XIAP-Casp3 XIAP-Casp9 XIAP-Casp9-Casp3
XIAP-p2 fragment XIAP-p2frag-Casp3 BIR12
BIR12-Casp3 BIR3R BIR3R-Casp9
BIR3R-p2frag XIAP-2*SMAC BIR12-SMAC
BIR3R-SMAC SMAC APAF1
XIAP-p2frag-2*SMAC Casp3 Substrate Clevage Products
cytosolic Cytochrome C    
mitochondrium SMAC in mitochondrium Cytochrome C in mitochondrium  
Global parameters
k1 k1r k2 k2r
k3 k4 k5 k6
k7 k7r k8 k8r
k9 k9r k10 k10r
k11 k12 k13 k14
k15 k16 k17 k18
k19 k20 k21 k21r
k22 k22r k23 k23r
k24 k25 k26 k26r
k27 k27r k28 k28r
k29 k29r k30 k30r
k31 k31r k32 k32r
k33 k33r k34 k34r
k35 k36 k37 k38
k39 k40 k41 k42
k43 k44 k45 k46
k47 k48 k49 k50
k51 k52 k53 t_SMAC_0.5
limiting factor for apoptosome formation t_Apop_0.5 th_CytC free SMAC per XIAP
initial XIAP conc XIAP2*SMAC per XIAP normalised Casp-9 Caspase9 tot
normalised Casp9-P normalised Casp-3 Caspase3 tot normalised Procasp-3
percent SMAC release total SMAC percent Apoptosome formation XIAP_norm
XIAP_C3_norm XIAP_C9_norm XIAP_p2frag_norm BIR12_norm
BIR3R_norm BIR12_C3_norm BIR3R_C9_norm BIR3R_p2frag_norm
S_breakdown CytC_tot APAF1_tot  
Reactions (56)
 
 ProCaspase3 Production  ↔ [ProCasp3];  
 
 XIAP Production  ↔ [XIAP];  
 
 reaction3 [Casp9(p35-p12)] + [ProCasp3] ↔ [C3] + [Casp9(p35-p12)];  
 
 reaction4 [Casp9(p35-p12)] + [C3] ↔ [Casp9(p35-p10)] + [C3];  
 
 reaction5 [Casp9(p35-p10)] + [ProCasp3] ↔ [Casp9(p35-p10)] + [C3];  
 
 reaction6 [ProCasp3] + [C3] ↔ 2.0 × [C3];  
 
 reaction7 [C3] + [XIAP] ↔ [XIAP-Casp3];  
 
 reaction8 [C3] + [XIAP-Casp9] ↔ [XIAP-Casp9-Casp3];  
 
 reaction9 [C3] + [XIAP-p2 fragment] ↔ [XIAP-p2frag-Casp3];  
 
 reaction10 [C3] + [BIR12] ↔ [BIR12-Casp3];  
 
 reaction11 [C3] + [XIAP] ↔ [BIR12] + [BIR3R] + [C3];  
 
 reaction12 [C3] + [XIAP-Casp9] ↔ [BIR12] + [BIR3R-Casp9] + [C3];  
 
 reaction13 [C3] + [XIAP-Casp3] ↔ [C3] + [BIR12-Casp3] + [BIR3R];  
 
 reaction14 [C3] + [XIAP-p2 fragment] ↔ [C3] + [BIR12] + [BIR3R-p2frag];  
 
 reaction15 [C3] + [XIAP-p2frag-Casp3] ↔ [C3] + [BIR12-Casp3] + [BIR3R-p2frag];  
 
 reaction16 [C3] + [XIAP-Casp9-Casp3] ↔ [C3] + [BIR12-Casp3] + [BIR3R-Casp9];  
 
 reaction17 [C3] + [XIAP-2*SMAC] ↔ [C3] + [BIR12-SMAC] + [BIR3R-SMAC];  
 
 reaction18 [C3] + [XIAP-Casp9-Casp3] ↔ [C3] + [Casp9(p35-p10)] + [XIAP-p2frag-Casp3];  
 
 reaction19 [C3] + [XIAP-Casp9] ↔ [C3] + [Casp9(p35-p10)] + [XIAP-p2 fragment];  
 
 reaction20 [C3] + [BIR3R-Casp9] ↔ [C3] + [BIR3R-p2frag] + [Casp9(p35-p10)];  
 
 reaction21 [Casp9(p35-p12)] + [XIAP] ↔ [XIAP-Casp9];  
 
 reaction22 [Casp9(p35-p12)] + [XIAP-Casp3] ↔ [XIAP-Casp9-Casp3];  
 
 reaction23 [Casp9(p35-p12)] + [BIR3R] ↔ [BIR3R-Casp9];  
 
 reaction24 [BIR3R-p2frag] ↔ [BIR3R];  
 
 reaction25 [XIAP-p2 fragment] ↔ [XIAP];  
 
 reaction26 [XIAP] + 2.0 × [SMAC] ↔ [XIAP-2*SMAC];  
 
 reaction27 [XIAP-Casp9] + 2.0 × [SMAC] ↔ [XIAP-2*SMAC] + [Casp9(p35-p12)];  
 
 reaction28 [XIAP-Casp3] + 2.0 × [SMAC] ↔ [XIAP-2*SMAC] + [C3];  
 
 reaction29 [XIAP-Casp9-Casp3] + 2.0 × [SMAC] ↔ [XIAP-2*SMAC] + [C3] + [Casp9(p35-p12)];  
 
 reaction30 [BIR12] + [SMAC] ↔ [BIR12-SMAC];  
 
 reaction31 [BIR3R] + [SMAC] ↔ [BIR3R-SMAC];  
 
 reaction32 [BIR12-Casp3] + [SMAC] ↔ [BIR12-SMAC] + [C3];  
 
 reaction33 [BIR3R-Casp9] + [SMAC] ↔ [BIR3R-SMAC] + [Casp9(p35-p12)];  
 
 reaction34 [XIAP-p2 fragment] + 2.0 × [SMAC] ↔ [XIAP-p2frag-2*SMAC];  
 
 reaction35 [Casp9(p35-p10)] ↔ ;  
 
 reaction36 [Casp9(p35-p12)] ↔ ;  
 
 reaction37 [C3] ↔ ;  
 
 reaction38 [XIAP-Casp3] ↔ ;  
 
 reaction39 [XIAP-Casp9-Casp3] ↔ ;  
 
 reaction40 [XIAP-Casp9] ↔ ;  
 
 reaction41 [XIAP-p2 fragment] ↔ ;  
 
 reaction42 [XIAP-p2frag-Casp3] ↔ ;  
 
 reaction43 [XIAP-p2frag-2*SMAC] ↔ ;  
 
 reaction44 [XIAP-2*SMAC] ↔ ;  
 
 reaction45 [BIR12] ↔ ;  
 
 reaction46 [BIR3R] ↔ ;  
 
 reaction47 [BIR12-SMAC] ↔ ;  
 
 reaction48 [BIR3R-SMAC] ↔ ;  
 
 reaction49 [BIR12-Casp3] ↔ ;  
 
 reaction50 [BIR3R-Casp9] ↔ ;  
 
 reaction51 [BIR3R-p2frag] ↔ ;  
 
 reaction52 [SMAC] ↔ ;  
 
 reaction53 [C3] + [Casp3 Substrate] ↔ [C3] + [Clevage Products];  
 
 SMAC_release [SMAC in mitochondrium] ↔ [SMAC];  
 
 Apo_formation [ProCasp9] + [APAF1] ↔ [Casp9(p35-p12)];  
 
 CytC_release [Cytochrome C in mitochondrium] ↔ [cytosolic Cytochrome C];  
 
Rules (18)
 
 Assignment Rule (name: apo_lim) limiting factor for apoptosome formation = piecewise(PC9, PC9 < APAF1, APAF1)
 
 Assignment Rule (name: SMAC_norm) free SMAC per XIAP = SMAC/XIAP_ini
 
 Assignment Rule (name: XIAP_2SMAC_norm) XIAP2*SMAC per XIAP = XIAP_2SMAC/XIAP_ini
 
 Assignment Rule (name: C9norm) normalised Casp-9 = C9/C9_tot
 
 Assignment Rule (name: C9Pnorm) normalised Casp9-P = C9P/C9_tot
 
 Assignment Rule (name: C3norm) normalised Casp-3 = C3/C3_tot
 
 Assignment Rule (name: PC3norm) normalised Procasp-3 = PC3/C3_tot
 
 Assignment Rule (name: SMAC_rel) percent SMAC release = 1-SMAC_mito/SMAC_tot
 
 Assignment Rule (name: Apoform) percent Apoptosome formation = 1-PC9/C9_tot
 
 Assignment Rule (name: XIAP_norm) XIAP_norm = XIAP/XIAP_ini
 
 Assignment Rule (name: XIAP_C3_norm) XIAP_C3_norm = (XIAP_C3+XIAP_C9_C3)/XIAP_ini
 
 Assignment Rule (name: XIAP_C9_norm) XIAP_C9_norm = (XIAP_C9+XIAP_C9_C3)/XIAP_ini
 
 Assignment Rule (name: XIAP_p2frag_norm) XIAP_p2frag_norm = (XIAP_p2frag+XIAP_p2frag_C3)/XIAP_ini
 
 Assignment Rule (name: BIR12_norm) BIR12_norm = BIR12/XIAP_ini
 
 Assignment Rule (name: BIR3R_norm) BIR3R_norm = BIR3R/XIAP_ini
 
 Assignment Rule (name: BIR12_C3_norm) BIR12_C3_norm = BIR12_C3/XIAP_ini
 
 Assignment Rule (name: BIR3R_C9_norm) BIR3R_C9_norm = BIR3R_C9/XIAP_ini
 
 Assignment Rule (name: BIR3R_p2frag_norm) BIR3R_p2frag_norm = BIR3R_p2frag/XIAP_ini
 
Events (1)
 
 Production_Breakdown
k51 = 0.0058
k50 = 0.0058
k48 = 0.0058
k46 = 0.0058
k44 = 0.0058
k43 = 0.0058
k40 = 0.0058
k39 = 0.0058
k38 = 0.0058
k2r = 0
k2 = 0
k1r = 0
k1 = 0
 
  Spatial dimensions: 3.0  Compartment size: 1.0
 
 ProCasp3
Compartment: cell
Initial concentration: 0.12
 
 XIAP
Compartment: cell
Initial concentration: 0.063
 
 Casp9(p35-p12)
Compartment: cell
Initial concentration: 0.0
 
 ProCasp9
Compartment: cell
Initial concentration: 0.03
 
 C3
Compartment: cell
Initial concentration: 0.0
 
 Casp9(p35-p10)
Compartment: cell
Initial concentration: 0.0
 
 XIAP-Casp3
Compartment: cell
Initial concentration: 0.0
 
 XIAP-Casp9
Compartment: cell
Initial concentration: 0.0
 
 XIAP-Casp9-Casp3
Compartment: cell
Initial concentration: 0.0
 
 XIAP-p2 fragment
Compartment: cell
Initial concentration: 0.0
 
 XIAP-p2frag-Casp3
Compartment: cell
Initial concentration: 0.0
 
 BIR12
Compartment: cell
Initial concentration: 0.0
 
 BIR12-Casp3
Compartment: cell
Initial concentration: 0.0
 
 BIR3R
Compartment: cell
Initial concentration: 0.0
 
 BIR3R-Casp9
Compartment: cell
Initial concentration: 0.0
 
 BIR3R-p2frag
Compartment: cell
Initial concentration: 0.0
 
 XIAP-2*SMAC
Compartment: cell
Initial concentration: 0.0
 
 BIR12-SMAC
Compartment: cell
Initial concentration: 0.0
 
 BIR3R-SMAC
Compartment: cell
Initial concentration: 0.0
 
 SMAC
Compartment: cell
Initial concentration: 0.0
 
 APAF1
Compartment: cell
Initial concentration: 3.372
 
 XIAP-p2frag-2*SMAC
Compartment: cell
Initial concentration: 0.0
 
 Casp3 Substrate
Compartment: cell
Initial concentration: 1.0
 
 Clevage Products
Compartment: cell
Initial concentration: 0.0
 
 cytosolic Cytochrome C
Compartment: cell
Initial concentration: 0.0
 
 mitochondrium Spatial dimensions: 3.0  Compartment size: 1.0
 
 SMAC in mitochondrium
Compartment: mitochondrium
Initial concentration: 0.126
 
 Cytochrome C in mitochondrium
Compartment: mitochondrium
Initial concentration: 10.0
 
Global Parameters (99)
 
   k1
Value: 4.68E-4   (Units: uM/min)
 
   k1r
Value: 0.0039   (Units: 1/min)
 
   k2
Value: 7.308E-4   (Units: uM/min)
 
   k2r
Value: 0.0116   (Units: 1/min)
 
   k3
Value: 6.0   (Units: 1/(uM*min))
Constant
 
   k4
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k5
Value: 48.0   (Units: 1/(uM*min))
Constant
 
   k6
Value: 2.4   (Units: 1/(uM*min))
Constant
 
   k7
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k7r
Value: 0.144   (Units: 1/min)
Constant
 
   k8
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k8r
Value: 0.144   (Units: 1/min)
Constant
 
   k9
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k9r
Value: 0.144   (Units: 1/min)
Constant
 
   k10
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k10r
Value: 0.144   (Units: 1/min)
Constant
 
   k11
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k12
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k13
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k14
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k15
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k16
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k17
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k18
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k19
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k20
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   k21
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k21r
Value: 0.144   (Units: 1/min)
Constant
 
   k22
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k22r
Value: 0.144   (Units: 1/min)
Constant
 
   k23
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k23r
Value: 0.144   (Units: 1/min)
Constant
 
   k24
Constant
 
   k25
Constant
 
   k26
Value: 420.0   (Units: 1/(uM^2*min))
Constant
 
   k26r
Value: 0.133   (Units: 1/min)
Constant
 
   k27
Value: 420.0   (Units: 1/(uM^2*min))
Constant
 
   k27r
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k28
Value: 420.0   (Units: 1/(uM^2*min))
Constant
 
   k28r
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k29
Value: 420.0   (Units: 1/(uM^2*min))
Constant
 
   k29r
Value: 156.0   (Units: 1/(uM^2*min))
Constant
 
   k30
Value: 4.45   (Units: 1/(uM*min))
Constant
 
   k30r
Value: 31.9   (Units: 1/min)
Constant
 
   k31
Value: 0.33   (Units: 1/(uM*min))
Constant
 
   k31r
Value: 14.2   (Units: 1/min)
Constant
 
   k32
Value: 4.45   (Units: 1/(uM*min))
Constant
 
   k32r
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k33
Value: 0.33   (Units: 1/(uM*min))
Constant
 
   k33r
Value: 156.0   (Units: 1/(uM*min))
Constant
 
   k34
Value: 420.0   (Units: 1/(uM^2*min))
Constant
 
   k34r
Value: 156.0   (Units: 1/min)
Constant
 
   k35
Value: 0.0058   (Units: 1/min)
Constant
 
   k36
Value: 0.0058   (Units: 1/min)
Constant
 
   k37
Value: 0.0058   (Units: 1/min)
Constant
 
   k38
Value: 0.0347   (Units: 1/min)
 
   k39
Value: 0.0347   (Units: 1/min)
 
   k40
Value: 0.0347   (Units: 1/min)
 
   k41
Value: 0.0058   (Units: 1/min)
Constant
 
   k42
Value: 0.0347   (Units: 1/min)
Constant
 
   k43
Value: 0.0347   (Units: 1/min)
 
   k44
Value: 0.0347   (Units: 1/min)
 
   k45
Value: 0.0058   (Units: 1/min)
Constant
 
   k46
Value: 0.0347   (Units: 1/min)
 
   k47
Value: 0.0058   (Units: 1/min)
Constant
 
   k48
Value: 0.0347   (Units: 1/min)
 
   k49
Value: 0.0058   (Units: 1/min)
Constant
 
   k50
Value: 0.0058   (Units: 1/min)
 
   k51
Value: 0.0347   (Units: 1/min)
 
   k52
Value: 0.0058   (Units: 1/min)
Constant
 
   k53
Value: 12.0   (Units: 1/(uM*min))
Constant
 
   t_SMAC_0.5
Value: 7.0   (Units: min)
Constant
 
   limiting factor for apoptosome formation
Value: NaN   (Units: microM)
 
   t_Apop_0.5
Value: 2.3   (Units: min)
Constant
 
   th_CytC
Value: 1.5   (Units: min)
Constant
 
   free SMAC per XIAP
Value: NaN   (Units: dimensionless)
 
   initial XIAP conc
Value: NaN   (Units: microM)
 
   XIAP2*SMAC per XIAP
Value: NaN   (Units: dimensionless)
 
   normalised Casp-9
Value: NaN   (Units: dimensionless)
 
   Caspase9 tot
Value: NaN   (Units: microM)
 
   normalised Casp9-P
Value: NaN   (Units: dimensionless)
 
   normalised Casp-3
Value: NaN   (Units: dimensionless)
 
   Caspase3 tot
Value: NaN   (Units: microM)
 
   normalised Procasp-3
Value: NaN   (Units: dimensionless)
 
   percent SMAC release
Value: NaN   (Units: dimensionless)
 
   total SMAC
Value: NaN   (Units: microM)
 
   percent Apoptosome formation
Value: NaN   (Units: dimensionless)
 
   XIAP_norm
Value: NaN   (Units: dimensionless)
 
   XIAP_C3_norm
Value: NaN   (Units: dimensionless)
 
   XIAP_C9_norm
Value: NaN   (Units: dimensionless)
 
   XIAP_p2frag_norm
Value: NaN   (Units: dimensionless)
 
   BIR12_norm
Value: NaN   (Units: dimensionless)
 
   BIR3R_norm
Value: NaN   (Units: dimensionless)
 
   BIR12_C3_norm
Value: NaN   (Units: dimensionless)
 
   BIR3R_C9_norm
Value: NaN   (Units: dimensionless)
 
   BIR3R_p2frag_norm
Value: NaN   (Units: dimensionless)
 
   S_breakdown
Value: 0.01   (Units: microM)
Constant
 
   CytC_tot
Value: NaN   (Units: microM)
 
   APAF1_tot
Value: NaN   (Units: microM)
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000256

Curator's comment: (updated: 30 Jul 2010 16:22:59 BST)

Reproduction of figure 2 d from the original publication using Copasi UI 4.6.
The concentrations are normalized using the initial XIAP concentration.

spacer
spacer