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BIOMD0000000255 - Chen2009 - ErbB Signaling

 

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Reference Publication
Publication ID: 19156131
Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK.
Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.
Mol. Syst. Biol. 2009; 5: 239
Department of Systems Biology, Center for Cell Decision Processes, Harvard Medical School, Boston, MA 02115, USA.  [more]
Model
Original Model: http://www.cdpcenter.org/w...
Submitter: Lukas Endler
Submission ID: MODEL1007260001
Submission Date: 26 Jul 2010 17:32:01 UTC
Last Modification Date: 21 Feb 2014 10:58:33 UTC
Creation Date: 26 Jul 2010 17:39:07 UTC
Encoders:  Lukas Endler
set #1
bqmodel:is BioModels Database MODEL1007260001
bqbiol:isVersionOf Reactome REACT_9417.3
Gene Ontology epidermal growth factor receptor signaling pathway
set #2
bqmodel:is BioModels Database Chen2009_ErbB_Signaling
set #3
bqbiol:occursIn Brenda Tissue Ontology BTO:0000567
bqbiol:hasTaxon Taxonomy Homo sapiens
bqmodel:isDerivedFrom BioModels Database Schoeberl2002_EGF_MAPK
bqbiol:hasVersion Gene Ontology MAPK cascade
Gene Ontology Ras protein signal transduction
Notes

This is A431 IERMv1.0 model described in the article
Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.
William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger and Peter K Sorger. Molecular Systems Biology 2009; 5:239. PMID: 19156131 , DOI: 10.1038/msb.2008.74

Abstract:
The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood how different ligands induce different responses and how this is affected by oncogenic mutations. To quantify signal flow through ErbB-activated pathways we have constructed, trained and analyzed a mass action model of immediate-early signaling involving ErbB1-4 receptors (EGFR, HER2/Neu2, ErbB3 and ErbB4), and the MAPK and PI3K/Akt cascades. We find that parameter sensitivity is strongly dependent on the feature (e.g. ERK or Akt activation) or condition (e.g. EGF or heregulin stimulation) under examination and that this context dependence is informative with respect to mechanisms of signal propagation. Modeling predicts log-linear amplification so that significant ERK and Akt activation is observed at ligand concentrations far below the K(d) for receptor binding. However, MAPK and Akt modules isolated from the ErbB model continue to exhibit switch-like responses. Thus, key system-wide features of ErbB signaling arise from nonlinear interaction among signaling elements, the properties of which appear quite different in context and in isolation.

The sbml model is available as supplemental material to the article and at http://www.cdpcenter.org/resources/models/chen-et-al-2008/ . It was slightly changed to make it valid SBML and to incorporate the step functions, described in the readme file and needed for inhibitor preincubation. the equilibration processes end at 1800 sec, so to reproduce the dynamics shown in the publication and supplemental material, only the time points after 1800 need to be considered. The parameter set is the hand fitted one used for Sfigure 3 in the supplemental materials. All species are in molecules, apart from HRG, EGF and Inh, which are in M.

The results shown in SFigure 3 can be calculated dividing the parameters ERK_PP , AKT_PP and ERB_B1_P_tot by ERK_t , AKT_t and EGFR_t , respectively. Somehow we did not find the right scaleing factor for the phosphorylated ErbB1 receptor. Therefore the model does only qualitatively reproduces the timecourses shown in the first row of Sfigure 3.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team.
For more information see the terms of use .
To cite BioModels Database, please use Le Nov������re N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

Model
Publication ID: 19156131 Submission Date: 26 Jul 2010 17:32:01 UTC Last Modification Date: 21 Feb 2014 10:58:33 UTC Creation Date: 26 Jul 2010 17:39:07 UTC
Mathematical expressions
Reactions
v1 EGF + ErbB1:ATP -> EGF:ErbB1:ATP k1 kd1 v2 (ErbB2:ErbB3) + EGF -> (ErbB3:ErbB2)#P k1c kd1c v3 ErbB2:ErbB4 + EGF -> (ErbB4:ErbB2)#P k1d kd1d v4 EGF + ErbB1:Inh -> EGF:ErbB1:Inh k1 kd1
v5 EGF:ErbB1:ATP + EGF:ErbB1:Inh -> (EGF:ErbB1:ErbB1):Inh k2 kd2 v6 EGF:ErbB1:Inh + EGF:ErbB1:Inh -> 2(EGF:ErbB1:Inh) k2 kd2 v7 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP)) k2 kd2 v8 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP) k2 kd2
v9 EGF:ErbB1:ATP + ErbB2 -> EGF:ErbB1:ErbB2 k2b kd2b v10 EGF:ErbB1:ATP + ErbB3 -> EGF:ErbB1:ErbB3 k2b kd2b v11 ErbB4 + EGF:ErbB1:ATP -> EGF:ErbB1:ErbB4 k2b kd2b v12 EGF:ErbB1:ATP + ErbB2 -> (EGF:ErbB1:ErbB2) k2b kd2b
v13 EGF:ErbB1:ATP + ErbB3 -> (EGF:ErbB1:ErbB3) k2b kd2b v14 EGF:ErbB1:ATP + ErbB4 -> (EGF:ErbB1:ErbB4) k2b kd2b v15 EGF:ErbB1:Inh + ErbB2 -> EGF:ErbB1:Inh:ErB2 k2b kd2b v16 ErbB3 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB3 k2b kd2b
v17 ErbB4 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB4 k2b kd2b v18 EGF:ErbB1:ATP + ErbB2:Inh -> (EGF:ErbB1:ErbB2):Inh k2b kd2b v19 EGF:ErbB1:ATP + ErbB4:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b v20 EGF:ErbB1:ATP + ErbB3:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b
v21 (EGF:ErbB1:ErbB2) + ATP -> (EGF:ErbB1:ErbB2):ATP k122 kd122 v22 (EGF:ErbB1:ErbB3) + ATP -> (EGF:ErbB1:ErbB3):ATP k122 kd122 v23 (EGF:ErbB1:ErbB4) + ATP -> (EGF:ErbB1:ErbB4):ATP k122 kd122 v24 2(EGF:ErbB1:ATP) + ATP -> 2(EGF:ErbB1):ATP k122 kd122
v25 2(EGF:ErbB1:ATP)) + ATP -> k122 kd122 v26 EGF:ErbB1:ErbB2 + ATP -> EGF:ErbB1:ErbB2:ATP k122 kd122 v27 EGF:ErbB1:ErbB3 + ATP -> EGF:ErbB1:ErbB3:ATP k122 kd122 v28 EGF:ErbB1:ErbB4 + ATP -> EGF:ErbB1:ErbB4:ATP k122 kd122
v29 ErbB2:ErbB2#P + ATP -> ErbB2:ErbB2#P:ATP k122 kd122 v30 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122 v31 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k122 kd122 v32 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k122 kd122
v33 2(ErbB2)#P:GAP:Grb2:Gab1 + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122 v34 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122 v35 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122 v36 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k122 kd122
v37 (HRG:ErbB3:ErbB1) + ATP -> (HRG:ErbB3:ErbB1):ATP k122 kd122 v38 (HRG:ErbB4:ErbB1) + ATP -> (HRG:ErbB4:ErbB1):ATP k122 kd122 v39 (HRG:ErbB4):ErbB2 + ATP -> (HRG:ErbB4):ErbB2:ATP k122 kd122 v40 (HRG:ErbB3):ErbB2 + ATP -> (HRG:ErbB3):ErbB2:ATP k122 kd122
v41 (HRG:ErbB3):ErbB2) + ATP -> (HRG:ErbB3):ErbB2):ATP k122 kd122 v42 (HRG:ErbB4):ErbB2) + ATP -> (HRG:ErbB4):ErbB2):ATP k122 kd122 v43 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k4 kd4 v44 2(EGF:ErbB1)#P:GAP:Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k4 kd4
v45 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4 kd4 v46 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4 v47 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k4 kd4 v48 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k4 kd4
v49 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4 kd4 v50 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4 kd4 v52 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 v53 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v54 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 v55 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 v56 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 v57 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v58 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 v59 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 v60 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 v61 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
v62 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 v63 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 v64 (ErbB1:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k4b kd4 v65 (ErbB1:ErbB3)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k4b kd4
v66 (ErbB1:ErbB4)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k4b kd4 v67 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 v68 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 v69 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v70 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4 v71 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4 v72 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4 v75 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
v76 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k4b kd4 v77 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k4b kd4 v78 2(ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 v79 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4
v80 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 v81 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 v82 2(ErbB2)#P:GAP:Grb2 + cPP -> 2(ErbB2)#P:GAP:Grb2:cPP k4b kd4 v83 2(ErbB2)#P:GAP:Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4
v84 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 v85 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4 v87 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 v88 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4
v89 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 v90 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 v91 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 v92 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4
v93 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 v94 (ErbB3:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k4b kd4 v95 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 v96 (ErbB4:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k4b kd4
v97 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4 v98 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4 v99 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 v100 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4
v101 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4 v102 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4 v103 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b v104 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b
v105 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b v106 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b v107 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b v108 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b
v109 cPP + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k5b kd5b v110 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b v111 cPP + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k5b kd5b v112 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b
v113 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b v114 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b v115 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b v116 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b
v117 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b v118 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b v120 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b v121 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v122 cPP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b v123 cPP + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:cPP k5 kd5b v124 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b v125 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v126 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b v127 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b v128 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k5 kd5b v129 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k5 kd5b
v130 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b v133 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b v134 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b v135 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v136 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b v137 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b v138 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b v139 cPP + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k5 kd5b
v140 cPP + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k5 kd5b v141 cPP + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k5 kd5b v142 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b v143 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b
v144 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b v145 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b v146 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b v147 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b
v148 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b v149 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b v150 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b v151 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b
v152 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b v153 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b v155 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5 v156 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5
v157 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5 v158 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k5 kd5 v159 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5 v160 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5
v161 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k5 kd5 v162 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k5 kd5 v163 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k6 kd6 v164 ErbB1:ATP -> ErbB1:ATP k6 kd6
v165 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P k6 kd6 v166 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP k6 kd6 v167 2(EGF:ErbB1)#P:GAP:Shc -> 2(EGF:ErbB1)#P:GAP:Shc k6 kd6 v168 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k6 kd6
v169 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k6 kd6 v170 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k6 kd6 v171 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k6 kd6 v172 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k6 kd6
v173 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k6 kd6 v174 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k6 kd6 v175 2(EGF:ErbB1)#P:GAP:Grb2 + -> 2(EGF:ErbB1)#P:GAP:Grb2 k6 kd6 v176 ErbB3 -> ErbB3 k6b kd6b
v177 ErbB2 -> ErbB2 k6b kd6b v178 ErbB4 -> ErbB4 k6b kd6b v179 (ErbB3:ErbB2)#P:GAP:Shc ->(ErbB3:ErbB2)#P:GAP:Shc k6b kd6b v180 (ErbB4:ErbB2)#P:GAP:Shc -> (ErbB4:ErbB2)#P:GAP:Shc k6 kd6
v181 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k6b kd6b v182 ErbB2:Inh -> ErbB2:Inh k6b kd6b v183 ErbB4:Inh -> ErbB4:Inh k6b kd6b v184 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k6b kd6b
v185 (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P k7 kd7 v186 (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P k7 kd7 v187 (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P k7 kd7 v188 2(ErbB2)#P -> 2(ErbB2)#P k7 kd7
v189 (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P k7 kd7 v190 (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P k7 kd7 v191 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP k7 kd7 v192 2(ErbB2)#P:GAP:Shc -> 2(ErbB2)#P:GAP:Shc k7 kd7
v193 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k7 kd7 v194 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8b kd8b v195 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b v196 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b
v197 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8 v198 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8 v199 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8 kd8 v200 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b
v201 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b v202 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8 v203 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8 v204 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8
v205 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8 v206 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8 v207 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8 v208 ErbB1:ATP + EGF -> EGF:ErbB1:ATP k10b kd10
v209 ErbB3 + -> (HRG:ErbB3) k10b kd10 v211 cPP + -> cPP k15 kd15 v212 Grb2 + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63 v213 Grb2 + (Shc#P) -> (Shc#P):Grb2 k16 kd24
v214 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24 v215 2(EGF:ErbB1)#P:GAP + Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63 v216 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24 v217 Grb2 + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24
v218 Grb2 + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24 v219 Grb2 + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24 v220 (ErbB1:ErbB2)#P:GAP + Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24 v221 (ErbB1:ErbB3)#P:GAP + Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24
v222 (ErbB1:ErbB4)#P:GAP + Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24 v223 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 v224 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24 v225 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24
v226 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 v227 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24 v228 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24 v229 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v230 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 v231 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63 v232 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63 v233 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24
v234 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 v235 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 v236 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 v237 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd63
v238 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd24 v239 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd24 v240 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd63 v241 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17
v242 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17 v243 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17 v244 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17 v245 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17
v246 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17 v247 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17 v248 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17 v249 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17
v250 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17 v251 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17 v252 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17 v253 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17
v254 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17 v255 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 v256 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v257 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v258 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v259 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v260 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v261 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v262 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v263 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v264 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v265 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v266 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 v267 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 v268 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 v269 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v270 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 v271 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v272 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v273 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v274 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 v275 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v276 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v277 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18
v278 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 v279 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 v280 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 v281 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18
v282 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 v283 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v284 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v285 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v286 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v287 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v288 (Ras:GTP)_i + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v289 Ras:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v290 (Ras:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v291 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v292 (Ras:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v293 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v294 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v295 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v296 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v297 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v298 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v299 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v300 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v301 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v302 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v303 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v304 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v305 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19
v306 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 v307 Ras:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v308 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v309 Ras:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19
v310 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 v311 Ras_activated:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v312 (Ras_activated:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v313 Ras_activated:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v314 (Ras_activated:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v315 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v316 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v317 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v318 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v319 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v320 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v321 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v322 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v323 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v324 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v325 Ras_activated:GTP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v326 Ras_activated:GTP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v327 Ras_activated:GTP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v328 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v329 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20
v330 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v331 Ras_activated:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v332 (Ras_activated:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 v333 2(ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v334 2(ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v335 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v336 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v337 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20
v338 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 v339 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v340 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v341 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v342 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v343 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v344 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v345 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v346 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v347 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v348 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v349 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v350 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v351 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v352 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v353 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v354 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v355 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v356 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v357 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v358 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v359 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v360 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v361 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21
v362 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 v363 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v364 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v365 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21
v366 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 v367 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22 v368 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22 v369 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b
v370 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b v371 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b v372 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b v373 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b
v374 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b v375 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b v376 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b v377 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b
v378 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b v379 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22 v380 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22 v381 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23
v382 (ErbB3:ErbB2)#P:GAP:Shc + -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k23 kd23 v383 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23 v384 (ErbB4:ErbB2)#P:GAP:Shc + -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k23 kd23 v385 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23
v386 2(ErbB2)#P:GAP:Shc + -> 2(ErbB2)#P:GAP:(Shc#P) k23 kd23 v387 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23 v388 2(EGF:ErbB1)#P:GAP:Shc + -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k23 kd23 v389 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23
v390 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23 v391 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23 v392 (ErbB1:ErbB2)#P:GAP:Shc + -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k23 kd23 v393 (ErbB1:ErbB3)#P:GAP:Shc + -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k23 kd23
v394 (ErbB1:ErbB4)#P:GAP:Shc + -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k23 kd23 v395 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v396 Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v397 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v398 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v399 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v400 Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v401 Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v402 Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v403 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v404 Sos + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v405 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25
v406 Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v407 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v408 Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k25 kd25 v409 Ras:GTP + Raf -> Raf:Ras:GTP k28 kd28
v410 (Ras:GTP)_i + Raf -> (Raf:Ras:GTP)_i k28 kd28 v411 (Ras_activated:GTP)_i + (Raf#P)_i -> (Raf:Ras:GTP)_i k29 kd29 v412 Ras_activated:GTP + Raf#P -> Raf:Ras:GTP k29 kd29 v413 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v414 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v415 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v416 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v417 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v418 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v419 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v420 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v421 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v422 2(ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v423 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v424 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v425 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32
v426 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k32 kd32 v427 (Shc#P) + Grb2:Sos -> (Shc#P):Grb2:Sos k33 kd33 v428 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34 v429 2(EGF:ErbB1)#P:GAP + Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k34 kd34
v430 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34 v431 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34 v432 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34 v433 (ErbB1:ErbB2)#P:GAP + Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k34 kd34
v434 (ErbB1:ErbB3)#P:GAP + Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k34 kd34 v435 (ErbB1:ErbB4)#P:GAP + Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k34 kd34 v436 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34 v437 2(ErbB2)#P:GAP + Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos k34 kd34
v438 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34 v439 (ErbB3:ErbB2)#P:GAP + Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k34 kd34 v440 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34 v441 (ErbB4:ErbB2)#P:GAP + Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k34 kd34
v442 Sos + Grb2 -> Grb2:Sos k35 kd35 v443 (Shc#P) + -> Shc k36 kd36 v444 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37 v445 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37
v446 2(EGF:ErbB1)#P:GAP + (Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k37 kd37 v447 2(EGF:ErbB1)#P:GAP + (Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k37 kd37 v448 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37 v449 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37
v450 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37 v451 (ErbB1:ErbB2)#P:GAP + (Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P) k37 kd37 v452 (ErbB1:ErbB3)#P:GAP + (Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P) k37 kd37 v453 (ErbB1:ErbB4)#P:GAP + (Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P) k37 kd37
v454 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37 v455 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37 v456 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37 v457 (ErbB1:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v458 (ErbB1:ErbB3)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k37 kd37 v459 (ErbB1:ErbB4)#P:GAP + (Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k37 kd37 v460 2(ErbB2)#P:GAP + (Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k37 kd37 v461 2(ErbB2)#P:GAP + (Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k37 kd37
v462 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37 v463 2(ErbB2)#P:GAP + (Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37 v464 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37 v465 (ErbB3:ErbB2)#P:GAP + (Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k37 kd37
v466 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37 v467 (ErbB4:ErbB2)#P:GAP + (Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k37 kd37 v468 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37 v469 (ErbB3:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37
v470 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37 v471 (ErbB4:ErbB2)#P:GAP + (Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k37 kd37 v472 Sos + (Shc#P):Grb2 -> (Shc#P):Grb2:Sos k40 kd40 v473 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v474 Grb2:Sos + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v475 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v476 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v477 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v478 Grb2:Sos + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v479 Grb2:Sos + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v480 Grb2:Sos + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v481 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v482 Grb2:Sos + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v483 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v484 Grb2:Sos + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v485 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41
v486 Grb2:Sos + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos k41 kd41 v487 Pase1 + (Raf#P)_i -> (Raf#P:Pase1)_i k42 kd42 v488 Pase1 + Raf#P -> Raf#P:Pase1 k42 kd42 v489 Raf + Pase1 -> Raf#P:Pase1 k43 kd43
v490 Raf + Pase1 -> (Raf#P:Pase1)_i k43 kd43 v491 (Raf#P)_i + (MEK#P)_i -> (MEK#P:Raf#P)_i k44 kd52 v492 MEK + (Raf#P)_i -> (MEK:Raf#P)_i k44 kd52 v493 MEK + Raf#P -> MEK:Raf#P k44 kd52
v494 MEK#P + Raf#P -> MEK#P:Raf#P k44 kd52 v495 MEK#P + Raf#P -> MEK:Raf#P k45 kd45 v496 (MEK#P)_i + (Raf#P)_i -> (MEK:Raf#P)_i k45 kd45 v497 MEK#P#P + Raf#P -> MEK#P:Raf#P k47 kd47
v498 (Raf#P)_i + (MEK#P#P)_i -> (MEK#P:Raf#P)_i k47 kd47 v499 (MEK#P#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k48 kd48 v500 MEK#P#P + Pase2 -> MEK#P#P:Pase2 k48 kd48 v501 MEK#P + Pase2 -> MEK#P#P:Pase2 k49 kd49
v502 MEK + Pase2 -> MEK#P:Pase2 k49 kd49 v503 MEK + Pase2 -> (MEK#P:Pase2)_i k49 kd49 v504 (MEK#P)_i + Pase2 -> (MEK#P#P:Pase2)_i k49 kd49 v505 Pase2 + (MEK#P)_i -> (MEK#P:Pase2)_i k50 kd50
v506 Pase2 + MEK#P -> MEK#P:Pase2 k50 kd50 v507 ERK + MEK#P#P -> ERK:MEK#P#P k52 kd44 v508 MEK#P#P + ERK#P -> ERK#P:MEK#P#P k52 kd44 v509 ERK + (MEK#P#P)_i -> MEK#P#P:ERK k52 kd44
v510 (MEK#P#P)_i + (ERK#P)_i -> MEK#P#P:ERK#P k52 kd44 v511 (ERK#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK k53 kd53 v512 MEK#P#P + ERK#P -> ERK:MEK#P#P k53 kd53 v513 ERK#P#P + MEK#P#P -> ERK#P:MEK#P#P k55 kd55
v514 (ERK#P#P)_i + (MEK#P#P)_i -> MEK#P#P:ERK#P k55 kd55 v515 ERK#P#P + Pase3 -> ERK#P#P:Pase3 k56 kd56 v516 (ERK#P#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k56 kd56 v517 (ERK#P)_i + Pase3 -> (ERK#P#P:Pase3)_i k57 kd57
v518 ERK#P + Pase3 -> ERK#P#P:Pase3 k57 kd57 v519 ERK + Pase3 -> ERK#P:Pase3 k57 kd57 v520 ERK + Pase3 -> (ERK#P:Pase3)_i k57 kd57 v521 Pase3 + ERK#P -> ERK#P:Pase3 k58 kd58
v522 Pase3 + (ERK#P)_i -> (ERK#P:Pase3)_i k58 kd58 v523 ErbB1:ATP -> R_degraded k60 kd60 v524 2(EGF:ErbB1:ATP) -> R_degraded k60 kd60 v525 2(EGF:ErbB1)#P:GAP -> R_degraded k60 kd60
v526 2(EGF:ErbB1)#P:GAP:Grb2 -> R_degraded k60 kd60 v527 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> R_degraded k60 kd60 v528 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60 v529 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60 kd60
v530 2(EGF:ErbB1)#P:GAP:Shc -> R_degraded k60 kd60 v531 2(EGF:ErbB1)#P:GAP:(Shc#P) -> R_degraded k60 kd60 v532 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> R_degraded k60 kd60 v533 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60 kd60
v534 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60 kd60 v535 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + -> R_degraded k60 kd60 v537 ErbB3 -> R_degraded k60b kd60b v538 ErbB2 -> R_degraded k60b kd60b
v539 ErbB4 -> R_degraded k60b kd60b v540 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60 v541 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60 v542 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60
v543 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60 v544 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60 v545 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60b kd60 v546 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60
v547 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60 v548 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60 v549 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60 v550 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v551 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60 v552 (ErbB1:ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60 v553 (ErbB1:ErbB3)#P:GAP:Grb2 -> R_degraded k60b kd60 v554 (ErbB1:ErbB4)#P:GAP:Grb2 -> R_degraded k60b kd60
v555 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60 v556 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60 v557 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60 v558 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v559 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60 v560 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60 v563 (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60 v564 (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> R_degraded k60b kd60
v565 (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> R_degraded k60b kd60 v566 2(ErbB2) -> R_degraded k60b kd60 v567 2(ErbB2)#P:GAP -> R_degraded k60b kd60 v568 2(ErbB2)#P:GAP:Shc -> R_degraded k60b kd60
v569 2(ErbB2)#P:GAP:(Shc#P) -> R_degraded k60b kd60 v570 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60b kd60 v572 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60 v573 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v574 2(ErbB2)#P:GAP:Grb2 -> R_degraded k60b kd60 v575 2(ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60b kd60 v576 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60b kd60 v577 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60b kd60
v579 (ErbB3:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60 v580 (ErbB4:ErbB2)#P:GAP:Shc -> R_degraded k60c kd60 v581 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60 v582 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> R_degraded k60c kd60
v583 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60 v584 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60 v585 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> R_degraded k60c kd60 v586 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> R_degraded k60c kd60
v587 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60 v588 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60 v589 (ErbB4:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60 v590 (ErbB3:ErbB2)#P:GAP:Grb2 -> R_degraded k60c kd60
v591 (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60 v592 (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> R_degraded k60c kd60 v593 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60 v594 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60
v595 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60 v596 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> R_degraded k60c kd60 v597 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60 v598 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> R_degraded k60c kd60
v599 EGF -> EGF_degraded k61 kd61 v600 (EGF:ErbB1:ErbB2) -> R_degraded k62b kd60b v601 (EGF:ErbB1:ErbB3) -> R_degraded k62b kd60b v602 (EGF:ErbB1:ErbB4) -> R_degraded k62b kd60b
v603 (HRG:ErbB3:ErbB1) -> R_degraded k62b kd60b v604 (HRG:ErbB4:ErbB1) -> R_degraded k62b kd60b v605 (HRG:ErbB3):ErbB2) -> R_degraded k62b kd60b v606 (HRG:ErbB4):ErbB2) -> R_degraded k62b kd60b
v607 (ErbB3:ErbB2) -> R_degraded k62b kd60b v608 (ErbB4:ErbB2) -> R_degraded k62b kd60b v609 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64 v610 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k64 kd64
v611 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k64 kd64 v612 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k64 kd64 v613 ERK#P#P + Sos -> (ERK#P#P):Sos k64 kd64 v614 (ERK#P#P)_i + Sos -> ((ERK#P#P):Sos)_i k64 kd64
v615 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65 v616 ERK#P#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:ERK#P#P k65 kd65 v617 ERK#P#P + Sos#P -> (ERK#P#P):Sos k65 kd65 v618 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(ERK#P#P) k65 kd65
v619 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(ERK#P#P) k65 kd65 v620 (ERK#P#P)_i + Sos#P -> ((ERK#P#P):Sos)_i k65 kd65 v621 PI3K + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66 v622 PI3K + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66
v623 PI3K + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66 v624 PI3K + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67 v625 PI3K + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67 v626 PI3K + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k67 kd67
v627 PI3K + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K k66 kd66 v628 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68b v629 PIP3 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68 v630 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K + PIP3 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68
v631 PIP3 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68 v632 PIP3 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68 v633 PIP3 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k68 kd68 v634 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k68 kd68b
v635 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k68 kd68b v636 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k68 kd68b v637 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k68 kd68b v638 PIP3 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k68 kd68b
v639 PIP3 + AKT -> PIP3:AKT k69 kd69 v640 PIP3 + AKT#P -> PIP3:AKT#P k69 kd69 v641 PDK1 + PIP3:AKT#P -> PIP3:AKT#P:PDK1 k70 kd70 v642 PDK1 + PIP3:AKT -> PIP3:AKT:PDK1 k70 kd70
v643 PIP3:PDK1 + AKT#P -> PIP3:AKT:PDK1 k71 kd71 v644 AKT#P#P + PIP3:PDK1 -> PIP3:AKT#P:PDK1 k72 kd72 v645 AKT#P#P + Pase4 -> AKT#P#P:Pase4 k74 kd74 v646 AKT#P + Pase4 -> AKT#P:Pase4 k73 kd73
v647 AKT + Pase4 -> AKT#P:Pase4 k75 kd75 v648 AKT#P + Pase4 -> AKT#P#P:Pase4 k75 kd75 v649 PDK1 + PIP3 -> PIP3:PDK1 k76 kd76 v650 RTK_Pase + (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P:RTK_Pase k94b kd94
v651 RTK_Pase + (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P:RTK_Pase k94b kd94 v652 RTK_Pase + 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P:RTK_Pase k94 kd94 v653 RTK_Pase + 2(ErbB2)#P -> 2(ErbB2)#P:RTK_Pase k94 kd94 v654 RTK_Pase + (ErbB3:ErbB2)#P -> (ErbB2:ErbB3)#P:RTK_Pase k94 kd94
v655 RTK_Pase + (ErbB4:ErbB2)#P -> (ErbB2:ErbB4)#P:RTK_Pase k94 kd94 v656 RTK_Pase + (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P:RTK_Pase k94 kd94 v657 RTK_Pase + (EGF:ErbB1:ErbB2) -> (ErbB1:ErbB2)#P:RTK_Pase k95 kd95 v658 RTK_Pase + (EGF:ErbB1:ErbB3) -> (ErbB1:ErbB3)#P:RTK_Pase k95 kd95
v659 RTK_Pase + (EGF:ErbB1:ErbB4) -> (ErbB1:ErbB4)#P:RTK_Pase k95 kd95 v660 RTK_Pase + 2(EGF:ErbB1:ATP) -> 2(EGF:ErbB1)#P:RTK_Pase k95 kd95 v661 RTK_Pase + 2(ErbB2) -> 2(ErbB2)#P:RTK_Pase k95 kd95 v662 RTK_Pase + (ErbB3:ErbB2) -> (ErbB2:ErbB3)#P:RTK_Pase k95 kd95
v663 RTK_Pase + (ErbB4:ErbB2) -> (ErbB2:ErbB4)#P:RTK_Pase k95 kd95 v664 ErbB2#P + ErbB2#P -> 2(ErbB2)#P k96 kd96 v665 ErbB1 + Inh -> ErbB1:Inh k97 kd97 v666 ErbB2 + Inh -> ErbB2:Inh k98 kd98
v667 ErbB4 + Inh -> ErbB4:Inh k99 kd99 v668 ErbB3 + Inh -> ErbB3:Inh k100 kd100 v669 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos#P k101 kd101 v670 Sos#P + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Sos#P) k101 kd101
v671 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101 v672 Sos#P + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:(Sos#P) k101 kd101 v673 EGF:ErbB1#P + EGF:ErbB1#P -> 2(EGF:ErbB1)#P k102 kd102 v674 ErbB2#P + EGF:ErbB1#P -> (ErbB1:ErbB2)#P k102 kd102
v675 EGF:ErbB1#P + ErbB3#P -> (ErbB1:ErbB3)#P k102 kd102 v676 EGF:ErbB1#P + ErbB4#P -> (ErbB1:ErbB4)#P k102 kd102 v677 ErbB2#P + ErbB2 -> ErbB2:ErbB2#P k103 kd103 v678 ErbB2 + ErbB3 -> (ErbB2:ErbB3) k103 kd103
v679 ErbB2 + ErbB4 -> ErbB2:ErbB4 k103 kd103 v680 ErbB2#P + ErbB3#P -> (ErbB3:ErbB2)#P k103 kd103 v681 ErbB2#P + ErbB4#P -> (ErbB4:ErbB2)#P k103 kd103 v682 ErbB2#P + ErbB2:Inh -> ErbB2:ErbB2:Inh k103 kd103
v683 ErbB2:Inh + ErbB3 -> ErbB3:ErbB2:Inh k103 kd103 v684 ErbB2:Inh + ErbB4 -> ErbB4:ErbB2:Inh k103 kd103 v685 ErbB2 + ErbB4:Inh -> ErbB4:Inh:ErbB2 k103 kd103 v686 Shp + PIP2 -> PIP3:Shp k104 kd104
v687 PTEN + PIP2 -> PIP3:PTEN k104 kd104 v688 2(EGF:ErbB1)#P:GAP:Grb2 + Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 k105 kd105 v689 (ErbB1:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105 v690 (ErbB1:ErbB3)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 k105 kd105
v691 (ErbB1:ErbB4)#P:GAP:Grb2 + Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 k105 kd105 v692 2(ErbB2)#P:GAP:Grb2 + Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1 k105 kd105 v693 (ErbB3:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105 v694 (ErbB4:ErbB2)#P:GAP:Grb2 + Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 k105 kd105
v695 PIP2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b v696 PIP2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b v697 PIP2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b v698 PIP2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106b kd106b
v699 PIP2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106 v700 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 k106 kd106 v701 PIP2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> PI3K k106 kd106 v702 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:PIP2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 k106 kd106
v703 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 k106 kd106 v704 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)3 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 k106 kd106 v705 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)4 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 k106 kd106 v706 PIP2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)5 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:(PIP2)6 k106 kd106
v707 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107 v708 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107 v709 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107 v710 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107
v711 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107 v712 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k107 kd107 v713 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k107 kd107 v714 Shp2 + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v715 Shp2 + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108 v716 Shp2 + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108 v717 Shp2 + 2(ErbB2)#P:GAP:Grb2:Gab1 -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108 v718 Shp2 + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108
v719 Shp2 + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 k108 kd108 v720 Shp2 + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):Shp2 k108 kd108 v721 PIP3 + PTEN -> PIP3:PTEN k109 kd109 v722 PIP3 + Shp -> PIP3:Shp k109 kd109
v723 ERK#P#P + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k110 kd110 v724 (ERK#P#P)_i + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k110 kd110 v725 ERK#P#P + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110 v726 (ERK#P#P)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v727 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110 v728 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110 v729 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k110 kd110 v730 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v731 ERK#P#P + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110 v732 (ERK#P#P)_i + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110 v733 ERK#P#P + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110 v734 (ERK#P#P)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110
v735 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k110 kd110 v736 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k110 kd110 v737 ERK#P#P + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111 v738 (ERK#P#P)_i + ErbB3/4:ErbB2:Gab1#P## -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v739 ERK#P#P + 2(ErbB2)2:Gab1#P## -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111 v740 (ERK#P#P)_i + 2(ErbB2)2:Gab1#P## -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111 v741 ERK#P#P + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P_ERK#P#P k111 kd111 v742 (ERK#P#P)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v743 ERK#P#P + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111 v744 (ERK#P#P)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111 v745 ERK#P#P + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111 v746 (ERK#P#P)_i + ErbB1:ErbB:Gab1#P## -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v747 ERK#P#P + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P k111 kd111 v748 (ERK#P#P)_i + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):ERK#P#P_i k111 kd111 v749 ERK#P#P + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P k111 kd111 v750 (ERK#P#P)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:ERK#P#P_i k111 kd111
v751 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k112 kd112 v752 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112 v753 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112 v754 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112
v755 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112 v756 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112 v757 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k112 kd112 v758 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Gab1#P:PI3K -> 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P):PI3K:Ras:GDP k113 kd113
v759 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113 v760 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113 v761 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113 v762 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> 2(ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113
v763 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113 v764 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:Shp2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P:PI3K:Ras:GDP k113 kd113 v765 AKT#P#P + Raf#P -> AKT:P:P:Raf:P:Ser k114 kd114 v766 AKT#P#P + (Raf#P)_i -> AKT:P:P:Raf:P:Ser_i k114 kd114
v767 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser k115 kd115 v768 Raf:P:Ser + AKT#P#P -> AKT:P:P:Raf:P:Ser_i k115 kd115 v769 Pase3 + -> MKP_deg k116 kd116 v770 Pase9t + 2(EGF:ErbB1):Gab1#P## -> 2(EGF:ErbB1):Gab1#P##:Pase9t k117 kd117
v771 Pase9t + 2(ErbB2)2:Gab1#P## -> 2(ErbB2)2:Gab1#P##:Pase9t k117 kd117 v772 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117 v773 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k117 kd117 v774 Pase9t + ErbB3/4:ErbB2:Gab1#P## -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k117 kd117
v775 Pase9t + ErbB1:ErbB:Gab1#P## -> ErbB1:ErbB:Gab1#P##:Pase9t k117 kd117 v776 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k117 kd117 v777 Pase9t + 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) -> 2(EGF:ErbB1):Gab1#P##:Pase9t k118 kd118 v778 Pase9t + 2(ErbB2)#P:GAP:Grb2:Gab1#P -> 2(ErbB2)2:Gab1#P##:Pase9t k118 kd118
v779 Pase9t + (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118 v780 Pase9t + (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1##P:Pase9t k118 kd118 v781 Pase9t + (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB3/4:ErbB2:Gab1#P##:Pase9t k118 kd118 v782 Pase9t + (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P -> ErbB1:ErbB:Gab1#P##:Pase9t k118 kd118
v783 Pase9t + (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:#P#P:Pase9t k118 kd118 v784 HRG + ErbB3 -> HRG:ErbB3 k119 kd119 v785 ErbB4 + HRG -> HRG:ErbB4 k119 kd119 v786 HRG:ErbB3 + ErbB2 -> (HRG:ErbB3):ErbB2 k120 kd120
v787 (HRG:ErbB3) + ErbB2 -> (HRG:ErbB3):ErbB2) k120 kd120 v788 + HRG:ErbB4 -> k120 kd120 v789 HRG:ErbB3 + ErbB1:ATP -> (HRG:ErbB3:ErbB1) k120b kd120 v790 HRG:ErbB4 + ErbB1:ATP -> (HRG:ErbB4:ErbB1) k120b kd120
v791 + (HRG:ErbB4) -> k120 kd120 v792 ErbB1:ATP + (HRG:ErbB3) -> (HRG:ErbB3:ErbB1) k120b kd120 v793 ErbB1:ATP + (HRG:ErbB4) -> (HRG:ErbB4:ErbB1) k120b kd120 v794 ErbB1_h + Inh -> ErbB1_h:Inh k97c kd97c
v795 EGF + ErbB1_h:Inh -> EGF:ErbB1_h:Inh k1 kd1 v796 EGF:ErbB1:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1:ErbB1_h:Inh k2 kd2 v797 EGF:ErbB1_h:Inh + EGF:ErbB1_h:Inh -> 2(EGF:ErbB1_h:Inh) k2 kd2 v798 EGF + ErbB1_h:ATP -> EGF:ErbB1_h:ATP k1 kd1
v799 ErbB1_h:ATP + -> ErbB1_h:ATP k6 kd6 v801 ErbB1_h:ATP + EGF -> EGF:ErbB1:ATP k10b kd10 v802 (EGF:ErbB1:ErbB1):Inh + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k122 kd122 v803 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ErbB1):Inh:ATP k123 kd123
v804 2(EGF:ErbB1)#P + ATP -> k123 kd123 v805 EGF:ErbB1:ErbB1_h:Inh + ATP -> k122 kd122 v806 2(EGF:ErbB1)#P + ATP -> k123 kd123 v807 (ErbB1:ErbB2)#P + ATP -> EGF:ErbB1:ErbB2:ATP k123 kd123
v808 (ErbB1:ErbB2)#P + ATP -> (EGF:ErbB1:ErbB2):ATP k123 kd123 v809 (ErbB1:ErbB3)#P + ATP -> (EGF:ErbB1:ErbB3):ATP k123 kd123 v810 (ErbB1:ErbB4)#P + ATP -> (EGF:ErbB1:ErbB4):ATP k123 kd123 v811 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1):ATP k123 kd123
v812 (ErbB1:ErbB3)#P + ATP -> EGF:ErbB1:ErbB3:ATP k123 kd123 v813 (ErbB1:ErbB4)#P + ATP -> EGF:ErbB1:ErbB4:ATP k123 kd123 v814 2(ErbB2)#P + ATP -> ErbB2:ErbB2#P:ATP k123 kd123 v815 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
v816 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k123 kd123 v817 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k123 kd123 v818 2(ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123 v819 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123
v820 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1#P + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k123 kd123 v821 2(EGF:ErbB1)#P:GAP:Grb2:(Gab1#P##) + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k123 kd123 v822 (ErbB1:ErbB3)#P + ATP -> (HRG:ErbB3:ErbB1):ATP k123 kd123 v823 (ErbB1:ErbB4)#P + ATP -> (HRG:ErbB4:ErbB1):ATP k123 kd123
v824 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2:ATP k123 kd123 v825 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2:ATP k123 kd123 v826 (ErbB3:ErbB2)#P + ATP -> (HRG:ErbB3):ErbB2):ATP k123 kd123 v827 (ErbB4:ErbB2)#P + ATP -> (HRG:ErbB4):ErbB2):ATP k123 kd123
v828 ErbB1 + ATP -> ErbB1:ATP k122 kd122 v829 ErbB1_h + ATP -> ErbB1_h:ATP k122 kd122 v850 EGF:ErbB1:ATP + EGF:ErbB1_h:ATP -> EGF:ErbB1:ATP::EGF:ErbB1_h:ATP k2 kd2 v851 EGF:ErbB1:Inh + EGF:ErbB1_h:ATP -> EGF:ErbB1:Inh::EGF:ErbB1_h:ATP k2 kd2
v852 EGF:ErbB1_h:ATP + EGF:ErbB1_h:ATP -> 2(EGF:ErbB1_h:ATP) k2 kd2 v853 EGF:ErbB1_h:ATP + EGF:ErbB1_h:Inh -> EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh k2 kd2 v854 EGF:ErbB1_h:Inh + EGF:ErbB1:Inh -> EGF:ErbB1_h:Inh::EGF:ErbB1:Inh k2 kd2 v855 EGF:ErbB1:ATP::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k122 kd122
v856 EGF:ErbB1:Inh::EGF:ErbB1_h:ATP + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k122 kd122 v857 2(EGF:ErbB1_h:ATP) + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k122 kd122 v858 EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k122 kd122 v859 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive k123 kd123
v860 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive k123h kd123h v861 2(EGF:ErbB1)#P + ATP -> 2(EGF:ErbB1_h:ATP)-FullActive k123 kd123 v862 2(EGF:ErbB1)#P + ATP -> (EGF:ErbB1_h:ATP::EGF:ErbB1_h:Inh)-HalfActive k123h kd123h  
Rules
Assignment Rule (variable: total ERK_PP) Assignment Rule (variable: total AKT_PP) Assignment Rule (variable: ERB_B1_P_dimer) Assignment Rule (variable: ERB_B1_4_P)
Assignment Rule (variable: ERB_B1_3_P) Assignment Rule (variable: ERB_B1_2_P) Assignment Rule (variable: total ERB-B1_P) Assignment Rule (variable: model_time)
Assignment Rule (variable: k116) Assignment Rule (variable: k97) Assignment Rule (variable: k97c) Assignment Rule (variable: k1)
Assignment Rule (variable: kd1) Assignment Rule (variable: k1c) Assignment Rule (variable: kd1c) Assignment Rule (variable: kd1d)
Assignment Rule (variable: kd6) Assignment Rule (variable: kd122) Assignment Rule (variable: k122) Assignment Rule (variable: k119)
Physical entities
Compartments Species
plasma membrane ErbB1:ATP EGF:ErbB1:ATP (ErbB2:ErbB3)
(ErbB3:ErbB2)_P ErbB2:ErbB4 (ErbB4:ErbB2)_P
ErbB1:Inh EGF:ErbB1:Inh (EGF:ErbB1:ATP::EGF:ErbB1:Inh)
2(EGF:ErbB1:Inh) 2(EGF:ErbB1:ATP) ErbB2
EGF:ErbB1:ErbB2 ErbB3 EGF:ErbB1:ErbB3
ErbB4 EGF:ErbB1:ErbB4 EGF:ErbB1:Inh:ErB2
EGF:ErbB1:Inh:ErB3 EGF:ErbB1:Inh:ErB4 ErbB2:Inh
(EGF:ErbB1:ErbB2):Inh ErbB4:Inh (EGF:ErbB1:ErbB3)_P:Inh
ErbB3:Inh (EGF:ErbB1:ErbB3)_P:Inh (ErbB1:ErbB2)_P:GAP:Grb2:Gab1
(ErbB1:ErbB3)_P:GAP:Grb2:Gab1 (ErbB1:ErbB4)_P:GAP:Grb2:Gab1 2(ErbB2)_P:GAP:Grb2:Gab1
(ErbB3:ErbB2)_P:GAP:Grb2:Gab1 (ErbB4:ErbB2)_P:GAP:Grb2:Gab1 2(EGF:ErbB1)_P:GAP:Grb2:Gab1
(HRG:ErbB3:ErbB1) (HRG:ErbB4:ErbB1) (HRG:ErbB4):ErbB2
(HRG:ErbB3):ErbB2 (HRG:ErbB3):ErbB2:ATP ((HRG:ErbB3):ErbB2):ATP
2(EGF:ErbB1)_P:GAP:Grb2 cPP 2(EGF:ErbB1)_P:GAP:Grb2:cPP
2(EGF:ErbB1)_P:GAP:Grb2:Sos 2(EGF:ErbB1)_P:GAP:Grb2:Sos:cPP 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)
2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP):cPP 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP) 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:cPP 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos
2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:cPP 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP
2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2
(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:cPP (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2 (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:cPP
(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2 (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:cPP (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos
(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:cPP
(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:cPP (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP
(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP (ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP
(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP (ErbB1:ErbB2)_P:GAP:Grb2
(ErbB1:ErbB2)_P:GAP:Grb2:cPP (ErbB1:ErbB3)_P:GAP:Grb2 (ErbB1:ErbB3)_P:GAP:Grb2:cPP
(ErbB1:ErbB4)_P:GAP:Grb2 (ErbB1:ErbB4)_P:GAP:Grb2:cPP (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP) (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP):cPP
(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP) (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP):cPP (ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP) (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP) (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP):cPP (ErbB1:ErbB2)_P:GAP:Grb2:Sos
(ErbB1:ErbB2)_P:GAP:Grb2:Sos:cPP (ErbB1:ErbB3)_P:GAP:Grb2:Sos (ErbB1:ErbB3)_P:GAP:Grb2:Sos:cPP
(ErbB1:ErbB4)_P:GAP:Grb2:Sos (ErbB1:ErbB4)_P:GAP:Grb2:Sos:cPP 2(ErbB2)_P:GAP:(Shc_P):Grb2
2(ErbB2)_P:GAP:(Shc_P):Grb2:cPP 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP
2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP 2(ErbB2)_P:GAP:Grb2 2(ErbB2)_P:GAP:Grb2:cPP
2(ErbB2)_P:GAP:Grb2:Sos 2(ErbB2)_P:GAP:Grb2:Sos:cPP 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP) 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2 (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:cPP (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2
(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:cPP (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP
(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP
(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP (ErbB3:ErbB2)_P:GAP:Grb2
(ErbB3:ErbB2)_P:GAP:Grb2:cPP (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP
(ErbB4:ErbB2)_P:GAP:Grb2 (ErbB4:ErbB2)_P:GAP:Grb2:cPP (ErbB3:ErbB2)_P:GAP:Grb2:Sos
(ErbB3:ErbB2)_P:GAP:Grb2:Sos:cPP (ErbB4:ErbB2)_P:GAP:Grb2:Sos (ErbB4:ErbB2)_P:GAP:Grb2:Sos:cPP
(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP) (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)
(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP) (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP
(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP) (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP 2(EGF:ErbB1)_P
2(EGF:ErbB1)_P:GAP 2(EGF:ErbB1)_P:GAP:Shc 2(EGF:ErbB1)_P:GAP:(Shc_P)
(ErbB3:ErbB2)_P:GAP:Shc (ErbB4:ErbB2)_P:GAP:Shc (ErbB3:ErbB2)_P:GAP:(Shc_P)
(ErbB4:ErbB2)_P:GAP:(Shc_P) (ErbB1:ErbB2)_P (ErbB1:ErbB3)_P
(ErbB1:ErbB4)_P 2(ErbB2)_P 2(ErbB2)_P:GAP
2(ErbB2)_P:GAP:Shc 2(ErbB2)_P:GAP:(Shc_P) (ErbB1:ErbB2)_P:GAP
(ErbB1:ErbB3)_P:GAP (ErbB1:ErbB4)_P:GAP (ErbB3:ErbB2)_P:GAP
(ErbB4:ErbB2)_P:GAP (ErbB1:ErbB2)_P:GAP:(Shc_P) (ErbB1:ErbB3)_P:GAP:(Shc_P)
(ErbB1:ErbB4)_P:GAP:(Shc_P) (ErbB1:ErbB2)_P:GAP:Shc (ErbB1:ErbB3)_P:GAP:Shc
(ErbB1:ErbB4)_P:GAP:Shc 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(ERK_PP) 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:ERK_PP
2(EGF:ErbB1)_P:GAP:Grb2:Sos_P 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:(Sos_P) 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P#)
2(EGF:ErbB1)_P:GAP:Grb2:Gab1_P:PI3K (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:PI3K
(ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P
(ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:PI3K 2(ErbB2)_P:GAP:Grb2:Gab1_P 2(ErbB2)_P:GAP:Grb2:Gab1_P:PI3K
(ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P
(ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:PIP2 2(ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:PIP2
2(EGF:ErbB1)_P:GAP:Grb2:Gab1_P:PI3K:PIP2 (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:PIP2 (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:PI3K:PIP2
(ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:PI3K:PIP2 (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)2 (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)3
(ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)4 (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)5 (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:(PIP2)6
ErbB2_P ErbB1 EGF:ErbB1_P
ErbB3_P ErbB4_P ErbB2:ErbB2:Inh
ErbB3:ErbB2:Inh ErbB4:ErbB2:Inh ErbB4:Inh:ErbB2
(ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:Shp2 (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:Shp2 (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:Shp2
2(ErbB2)_P:GAP:Grb2:Gab1_P:Shp2 (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:Shp2 (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:Shp2
2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):Shp2 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):ERK_PP 2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):ERK_PP_i
(ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:ERK_PP
2(ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP 2(ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP
(ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP (ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:ERK_PP_i
ErbB3/4:ErbB2:Gab1_P# 2(ErbB2)2:Gab1_P# (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P
(ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P 2(EGF:ErbB1):Gab1_P# (ErbB4:ErbB2)_P:GAP:Grb2:Gab1:_PP
2(EGF:ErbB1)_P:GAP:Grb2:(Gab1_P):PI3K:Ras:GDP (ErbB1:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP
(ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP 2(ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP (ErbB3:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP
(ErbB4:ErbB2)_P:GAP:Grb2:Gab1_P:PI3K:Ras:GDP Raf:P:Ser 2(EGF:ErbB1):Gab1_P#:Pase9t
2(ErbB2)2:Gab1_P#:Pase9t (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:Pase9t ErbB3/4:ErbB2:Gab1_P#:Pase9t
ErbB1:ErbB:Gab1_P#:Pase9t (ErbB4:ErbB2)_P:GAP:Grb2:Gab1:_PP:Pase9t HRG:ErbB3
HRG:ErbB4 ErbB1_h ErbB1_h:Inh
EGF:ErbB1_h:Inh (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh) 2(EGF:ErbB1_h:Inh)
ErbB1_h:ATP EGF:ErbB1_h:ATP (EGF:ErbB1:ATP::EGF:ErbB1:Inh)-HalfActive
(EGF:ErbB1:ATP::EGF:ErbB1_h:ATP) (EGF:ErbB1:Inh::EGF:ErbB1_h:ATP) 2(EGF:ErbB1_h:ATP)-FullActive
(EGF:ErbB1:ATP::EGF:ErbB1_h:Inh) (EGF:ErbB1:Inh::EGF:ErbB1_h:Inh) (EGF:ErbB1:ATP::EGF:ErbB1_h:ATP)-FullActive
(EGF:ErbB1:Inh::EGF:ErbB1_h:ATP)-HalfActive 2(EGF:ErbB1_h:ATP)-FullActive (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive
endosomes EGF HRG (ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:ERK_PP_i
(ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P_ERK_PP (ErbB1:ErbB4)_P:GAP:Grb2:Gab1_P:ERK_PP_i ErbB1_h:ATP
     
lysosomes R_degraded EGF_degraded  
medium EGF Inh HRG
     
endosomal membrane EGF:ErbB1:ATP 2(EGF:ErbB1:ATP) ErbB2
(EGF:ErbB1:ErbB2) ErbB3 (EGF:ErbB1:ErbB3)
ErbB4 (EGF:ErbB1:ErbB4) ErbB2:ErbB2_P
(HRG:ErbB3):ErbB2) ((HRG:ErbB4):ErbB2) ((HRG:ErbB4):ErbB2):ATP
cPP (ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP) (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP) (ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP) (ErbB4:ErbB2)_P:GAP:Grb2:Sos
(ErbB3:ErbB2)_P:GAP:Grb2:Sos (ErbB4:ErbB2)_P:GAP:Grb2 (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos
(ErbB3:ErbB2)_P:GAP:Grb2 (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) (ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos
(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2 (ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2 2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)
2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP) 2(ErbB2)_P:GAP:Grb2:Sos 2(ErbB2)_P:GAP:Grb2
2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) 2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos
2(ErbB2)_P:GAP:(Shc_P):Grb2 (ErbB1:ErbB4)_P:GAP:Grb2:Sos (ErbB1:ErbB3)_P:GAP:Grb2:Sos
(ErbB1:ErbB2)_P:GAP:Grb2:Sos (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP) (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)
(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP) (ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP) (ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)
(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP) (ErbB1:ErbB4)_P:GAP:Grb2 (ErbB1:ErbB3)_P:GAP:Grb2
(ErbB1:ErbB2)_P:GAP:Grb2 (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)
(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP) (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos
(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos (ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2 (ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2
(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP) 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)
2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)
2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP) 2(EGF:ErbB1)_P:GAP:Grb2 2(EGF:ErbB1)_P:GAP:Grb2:Sos
ErbB1:ATP 2(EGF:ErbB1)_P 2(EGF:ErbB1)_P:GAP
2(EGF:ErbB1)_P:GAP:Shc 2(EGF:ErbB1)_P:GAP:(Shc_P) (ErbB3:ErbB2)_P:GAP:Shc
(ErbB4:ErbB2)_P:GAP:Shc (ErbB3:ErbB2)_P:GAP:(Shc_P) ErbB2:Inh
ErbB4:Inh (ErbB4:ErbB2)_P:GAP:(Shc_P) (ErbB1:ErbB2)_P
(ErbB1:ErbB3)_P (ErbB1:ErbB4)_P 2(ErbB2)_P
(ErbB3:ErbB2)_P (ErbB4:ErbB2)_P 2(ErbB2)_P:GAP
2(ErbB2)_P:GAP:Shc 2(ErbB2)_P:GAP:(Shc_P) (ErbB1:ErbB2)_P:GAP
(ErbB1:ErbB3)_P:GAP (ErbB1:ErbB4)_P:GAP (ErbB3:ErbB2)_P:GAP
(ErbB4:ErbB2)_P:GAP (HRG:ErbB3) (ErbB1:ErbB2)_P:GAP:(Shc_P)
(ErbB1:ErbB3)_P:GAP:(Shc_P) (ErbB1:ErbB4)_P:GAP:(Shc_P) (ErbB1:ErbB2)_P:GAP:Shc
(ErbB1:ErbB3)_P:GAP:Shc (ErbB1:ErbB4)_P:GAP:Shc 2(ErbB2)
(HRG:ErbB3:ErbB1) (HRG:ErbB4:ErbB1) (ErbB3:ErbB2)
(ErbB4:ErbB2) 2(EGF:ErbB1)_P:GAP:Grb2:Sos:(ERK_PP) 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(ERK_PP)
2(EGF:ErbB1)_P:GAP:Grb2:(Sos_P) 2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:(Sos_P) (ErbB1:ErbB3)_P:RTK_Pase
(ErbB1:ErbB4)_P:RTK_Pase 2(EGF:ErbB1)_P:RTK_Pase 2(ErbB2)_P:RTK_Pase
(ErbB2:ErbB3)_P:RTK_Pase (ErbB2:ErbB4)_P:RTK_Pase (ErbB1:ErbB2)_P:RTK_Pase
(ErbB1:ErbB3)_P:GAP:Grb2:Gab1_P:Pase9t (HRG:ErbB4)  
cytoplasm ATP 1.2e9 (EGF:ErbB1:ErbB2):ATP (EGF:ErbB1:ErbB3):ATP
(EGF:ErbB1:ErbB4):ATP 2(EGF:ErbB1):ATP 2(EGF:ErbB1:ATP)-FullActive
EGF:ErbB1:ErbB2:ATP EGF:ErbB1:ErbB3:ATP EGF:ErbB1:ErbB4:ATP
ErbB2:ErbB2_P:ATP (ErbB1:ErbB2)_P:GAP:Grb2:Gab1:ATP (ErbB1:ErbB3)_P:GAP:Grb2:Gab1:ATP
(ErbB1:ErbB4)_P:GAP:Grb2:Gab1:ATP 2(ErbB2)_P:GAP:Grb2:Gab1:ATP (ErbB3:ErbB2)_P:GAP:Grb2:Gab1:ATP
(ErbB4:ErbB2)_P:GAP:Grb2:Gab1:ATP 2(EGF:ErbB1)_P:GAP:Grb2:Gab1:ATP (HRG:ErbB3:ErbB1):ATP
(HRG:ErbB4:ErbB1):ATP (HRG:ErbB4):ErbB2:ATP GAP
Grb2 (Shc_P) (Shc_P):Grb2
Sos Ras:GDP Ras:GTP
(Ras:GTP)_i Ras_activated:GTP (Ras_activated:GTP)_i
Shc Raf Raf:Ras:GTP
(Raf:Ras:GTP)_i (Raf_P)_i Raf_P
(Shc_P):Grb2:Sos Grb2:Sos Pase1
(Raf_P:Pase1)_i Raf_P:Pase1 (MEK_P)_i
(MEK_P:Raf_P)_i MEK (MEK:Raf_P)_i
MEK:Raf_P MEK_P MEK_P:Raf_P
MEK_PP (MEK_PP)_i Pase2
(MEK_PP:Pase2)_i MEK_PP:Pase2 MEK_P:Pase2
(MEK_P:Pase2)_i ERK ERK:MEK_PP
ERK_P ERK_P:MEK_PP MEK_PP:ERK
(ERK_P)_i MEK_PP:ERK_P ERK_PP
(ERK_PP)_i Pase3 ERK_PP:Pase3
(ERK_PP:Pase3)_i ERK_P:Pase3 (ERK_P:Pase3)_i
(ERK_PP):Sos ((ERK_PP):Sos)_i Sos_P
PI3K PIP3 AKT
PIP3:AKT AKT_P PIP3:AKT_P
PDK1 PIP3:AKT_P:PDK1 PIP3:AKT:PDK1
PIP3:PDK1 AKT:P:P Pase4
AKT:P:P:Pase4 AKT_P:Pase4 RTK_Pase
Shp PIP2 PIP3:Shp
PTEN PIP3:PTEN Gab1
PI3K Shp2 ErbB1:ErbB:Gab1_P#
AKT:P:P:Raf:P:Ser AKT:P:P:Raf:P:Ser_i MKP_deg
Pase9t (EGF:ErbB1:ATP::EGF:ErbB1_h:Inh)-HalfActive  
Global parameters
total ERB-B1_P ERB_B1_P_dimer ERB_B1_4_P ERB_B1_3_P
ERB_B1_2_P total EGF receptor total ERK total ERK_PP
total AKT total AKT_PP model_time kd1
k1c kd1c kd1d k1d
k2 kd2 k2b kd2b
k3 kd3 k4 kd4
k4b kd4b k5 kd5
k5b kd5b kd5c k6
kd6 k8 kd8 kd8b
k8b k10 k10b kd10
k13 kd13 k14 kd14
k15 kd15 k16 k16b
k17 kd17 k18 kd18
k19 kd19 k20 kd20
k21 kd21 k22 kd22
k23 kd23 kd24 k25
kd25 k28 kd28 k28b
kd28b k29 kd29 kd32
k32 kd33 k33 kd34
k34 kd35 k35 k36
kd36 kd37 k37 k40
kd40 k41 kd41 k42
kd42 kd43 k43 kd44
kd45 k45 kd47 k47
k48 kd48 kd49 k49
k50 kd50 kd52 kd53
k53 kd55 k55 kd56
k56 kd57 k57 k58
kd58 k52 k44 k60
kd60 k61 kd61 kd63
k64 kd64 kd65 k65
k66 kd66 k67 kd67
kd68 k68 kd68b k69
kd69 k70 kd70 k71
kd71 k72 kd72 k73
kd73 k74 kd74 kd75
k75 k76 kd76 kd60d
k22b kd22b kd34b k34b
k94b k94 kd94 k95
kd95 k96 kd96 kd6b
k7 kd7 k62b kd60b
k60c k60b KD_iressa_wt k97
kd97 KD_iressa_mt k97c kd97c
Kinh2 kd98 k98 Kinh4
kd99 k99 Kinh3 kd100
k100 k101 kd101 k102
kd102 k103 kd103 k104
kd104 k105 kd105 k106
kd106 k106b kd106b k107
kd107 k108 kd108 k109
kd109 k110 kd110 kd111
k111 k112 kd112 k113
kd113 k114 kd114 k115
kd115 k116 kd116 k117
kd117 k118 kd118 kd119
k119 k120 kd120 k120b
kd120b Ks k121 kd121
kd122 k123 kd123 k6b
k1 k122 KD_ATP k123h
kd123h KD    
Reactions (827)
 
 v1 EGF + ErbB1:ATP -> EGF:ErbB1:ATP k1 kd1 [EGF] + [ErbB1:ATP] ↔ [EGF:ErbB1:ATP];  
 
 v2 (ErbB2:ErbB3) + EGF -> (ErbB3:ErbB2)#P k1c kd1c [(ErbB2:ErbB3)] + [EGF] ↔ [(ErbB3:ErbB2)_P];  
 
 v3 ErbB2:ErbB4 + EGF -> (ErbB4:ErbB2)#P k1d kd1d [ErbB2:ErbB4] + [EGF] ↔ [(ErbB4:ErbB2)_P];  
 
 v4 EGF + ErbB1:Inh -> EGF:ErbB1:Inh k1 kd1 [EGF] + [ErbB1:Inh] ↔ [EGF:ErbB1:Inh];  
 
 v5 EGF:ErbB1:ATP + EGF:ErbB1:Inh -> (EGF:ErbB1:ErbB1):Inh k2 kd2 [EGF:ErbB1:ATP] + [EGF:ErbB1:Inh] ↔ [(EGF:ErbB1:ATP::EGF:ErbB1:Inh)];  
 
 v6 EGF:ErbB1:Inh + EGF:ErbB1:Inh -> 2(EGF:ErbB1:Inh) k2 kd2 [EGF:ErbB1:Inh] + [EGF:ErbB1:Inh] ↔ [2(EGF:ErbB1:Inh)];  
 
 v7 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP)) k2 kd2 [EGF:ErbB1:ATP] + [EGF:ErbB1:ATP] ↔ [2(EGF:ErbB1:ATP)];  
 
 v8 EGF:ErbB1:ATP + EGF:ErbB1:ATP -> 2(EGF:ErbB1:ATP) k2 kd2 [EGF:ErbB1:ATP] + [EGF:ErbB1:ATP] ↔ [2(EGF:ErbB1:ATP)];  
 
 v9 EGF:ErbB1:ATP + ErbB2 -> EGF:ErbB1:ErbB2 k2b kd2b [EGF:ErbB1:ATP] + [ErbB2] ↔ [EGF:ErbB1:ErbB2];  
 
 v10 EGF:ErbB1:ATP + ErbB3 -> EGF:ErbB1:ErbB3 k2b kd2b [EGF:ErbB1:ATP] + [ErbB3] ↔ [EGF:ErbB1:ErbB3];  
 
 v11 ErbB4 + EGF:ErbB1:ATP -> EGF:ErbB1:ErbB4 k2b kd2b [ErbB4] + [EGF:ErbB1:ATP] ↔ [EGF:ErbB1:ErbB4];  
 
 v12 EGF:ErbB1:ATP + ErbB2 -> (EGF:ErbB1:ErbB2) k2b kd2b [EGF:ErbB1:ATP] + [ErbB2] ↔ [(EGF:ErbB1:ErbB2)];  
 
 v13 EGF:ErbB1:ATP + ErbB3 -> (EGF:ErbB1:ErbB3) k2b kd2b [EGF:ErbB1:ATP] + [ErbB3] ↔ [(EGF:ErbB1:ErbB3)];  
 
 v14 EGF:ErbB1:ATP + ErbB4 -> (EGF:ErbB1:ErbB4) k2b kd2b [EGF:ErbB1:ATP] + [ErbB4] ↔ [(EGF:ErbB1:ErbB4)];  
 
 v15 EGF:ErbB1:Inh + ErbB2 -> EGF:ErbB1:Inh:ErB2 k2b kd2b [EGF:ErbB1:Inh] + [ErbB2] ↔ [EGF:ErbB1:Inh:ErB2];  
 
 v16 ErbB3 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB3 k2b kd2b [ErbB3] + [EGF:ErbB1:Inh] ↔ [EGF:ErbB1:Inh:ErB3];  
 
 v17 ErbB4 + EGF:ErbB1:Inh -> EGF:ErbB1:Inh:ErB4 k2b kd2b [ErbB4] + [EGF:ErbB1:Inh] ↔ [EGF:ErbB1:Inh:ErB4];  
 
 v18 EGF:ErbB1:ATP + ErbB2:Inh -> (EGF:ErbB1:ErbB2):Inh k2b kd2b [EGF:ErbB1:ATP] + [ErbB2:Inh] ↔ [(EGF:ErbB1:ErbB2):Inh];  
 
 v19 EGF:ErbB1:ATP + ErbB4:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b [EGF:ErbB1:ATP] + [ErbB4:Inh] ↔ [(EGF:ErbB1:ErbB3)_P:Inh];  
 
 v20 EGF:ErbB1:ATP + ErbB3:Inh -> (EGF:ErbB1:ErbB3)#P:Inh k2b kd2b [EGF:ErbB1:ATP] + [ErbB3:Inh] ↔ [(EGF:ErbB1:ErbB3)_P:Inh];  
 
 v21 (EGF:ErbB1:ErbB2) + ATP -> (EGF:ErbB1:ErbB2):ATP k122 kd122 [(EGF:ErbB1:ErbB2)] + [ATP 1.2e9] ↔ [(EGF:ErbB1:ErbB2):ATP];  
 
 v22 (EGF:ErbB1:ErbB3) + ATP -> (EGF:ErbB1:ErbB3):ATP k122 kd122 [(EGF:ErbB1:ErbB3)] + [ATP 1.2e9] ↔ [(EGF:ErbB1:ErbB3):ATP];  
 
 v23 (EGF:ErbB1:ErbB4) + ATP -> (EGF:ErbB1:ErbB4):ATP k122 kd122 [(EGF:ErbB1:ErbB4)] + [ATP 1.2e9] ↔ [(EGF:ErbB1:ErbB4):ATP];  
 
 v24 2(EGF:ErbB1:ATP) + ATP -> 2(EGF:ErbB1):ATP k122 kd122 [2(EGF:ErbB1:ATP)] + [ATP 1.2e9] ↔ [2(EGF:ErbB1):ATP];  
 
 v25 2(EGF:ErbB1:ATP)) + ATP -> k122 kd122 [2(EGF:ErbB1:ATP)] + [ATP 1.2e9] ↔ [2(EGF:ErbB1:ATP)-FullActive];  
 
 v26 EGF:ErbB1:ErbB2 + ATP -> EGF:ErbB1:ErbB2:ATP k122 kd122 [EGF:ErbB1:ErbB2] + [ATP 1.2e9] ↔ [EGF:ErbB1:ErbB2:ATP];  
 
 v27 EGF:ErbB1:ErbB3 + ATP -> EGF:ErbB1:ErbB3:ATP k122 kd122 [EGF:ErbB1:ErbB3] + [ATP 1.2e9] ↔ [EGF:ErbB1:ErbB3:ATP];  
 
 v28 EGF:ErbB1:ErbB4 + ATP -> EGF:ErbB1:ErbB4:ATP k122 kd122 [EGF:ErbB1:ErbB4] + [ATP 1.2e9] ↔ [EGF:ErbB1:ErbB4:ATP];  
 
 v29 ErbB2:ErbB2#P + ATP -> ErbB2:ErbB2#P:ATP k122 kd122 [ErbB2:ErbB2_P] + [ATP 1.2e9] ↔ [ErbB2:ErbB2_P:ATP];  
 
 v30 (ErbB1:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122 [(ErbB1:ErbB2)_P:GAP:Grb2:Gab1] + [ATP 1.2e9] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Gab1:ATP];  
 
 v31 (ErbB1:ErbB3)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB3)#P:GAP:Grb2:Gab1:ATP k122 kd122 [(ErbB1:ErbB3)_P:GAP:Grb2:Gab1] + [ATP 1.2e9] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Gab1:ATP];  
 
 v32 (ErbB1:ErbB4)#P:GAP:Grb2:Gab1 + ATP -> (ErbB1:ErbB4)#P:GAP:Grb2:Gab1:ATP k122 kd122 [(ErbB1:ErbB4)_P:GAP:Grb2:Gab1] + [ATP 1.2e9] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Gab1:ATP];  
 
 v33 2(ErbB2)#P:GAP:Grb2:Gab1 + ATP -> 2(ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122 [2(ErbB2)_P:GAP:Grb2:Gab1] + [ATP 1.2e9] ↔ [2(ErbB2)_P:GAP:Grb2:Gab1:ATP];  
 
 v34 (ErbB3:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB3:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122 [(ErbB3:ErbB2)_P:GAP:Grb2:Gab1] + [ATP 1.2e9] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Gab1:ATP];  
 
 v35 (ErbB4:ErbB2)#P:GAP:Grb2:Gab1 + ATP -> (ErbB4:ErbB2)#P:GAP:Grb2:Gab1:ATP k122 kd122 [(ErbB4:ErbB2)_P:GAP:Grb2:Gab1] + [ATP 1.2e9] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Gab1:ATP];  
 
 v36 2(EGF:ErbB1)#P:GAP:Grb2:Gab1 + ATP -> 2(EGF:ErbB1)#P:GAP:Grb2:Gab1:ATP k122 kd122 [2(EGF:ErbB1)_P:GAP:Grb2:Gab1] + [ATP 1.2e9] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Gab1:ATP];  
 
 v37 (HRG:ErbB3:ErbB1) + ATP -> (HRG:ErbB3:ErbB1):ATP k122 kd122 [(HRG:ErbB3:ErbB1)] + [ATP 1.2e9] ↔ [(HRG:ErbB3:ErbB1):ATP];  
 
 v38 (HRG:ErbB4:ErbB1) + ATP -> (HRG:ErbB4:ErbB1):ATP k122 kd122 [(HRG:ErbB4:ErbB1)] + [ATP 1.2e9] ↔ [(HRG:ErbB4:ErbB1):ATP];  
 
 v39 (HRG:ErbB4):ErbB2 + ATP -> (HRG:ErbB4):ErbB2:ATP k122 kd122 [(HRG:ErbB4):ErbB2] + [ATP 1.2e9] ↔ [(HRG:ErbB4):ErbB2:ATP];  
 
 v40 (HRG:ErbB3):ErbB2 + ATP -> (HRG:ErbB3):ErbB2:ATP k122 kd122 [(HRG:ErbB3):ErbB2] + [ATP 1.2e9] ↔ [(HRG:ErbB3):ErbB2:ATP];  
 
 v41 (HRG:ErbB3):ErbB2) + ATP -> (HRG:ErbB3):ErbB2):ATP k122 kd122 [(HRG:ErbB3):ErbB2)] + [ATP 1.2e9] ↔ [((HRG:ErbB3):ErbB2):ATP];  
 
 v42 (HRG:ErbB4):ErbB2) + ATP -> (HRG:ErbB4):ErbB2):ATP k122 kd122 [((HRG:ErbB4):ErbB2)] + [ATP 1.2e9] ↔ [((HRG:ErbB4):ErbB2):ATP];  
 
 v43 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k4 kd4 [2(EGF:ErbB1)_P:GAP:Grb2] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:cPP];  
 
 v44 2(EGF:ErbB1)#P:GAP:Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k4 kd4 [2(EGF:ErbB1)_P:GAP:Grb2:Sos] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:cPP];  
 
 v45 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4 kd4 [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v46 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4 [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v47 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k4 kd4 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v48 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k4 kd4 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v49 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4 kd4 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v50 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4 kd4 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v52 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2] + [cPP] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v53 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2] + [cPP] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v54 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2] + [cPP] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v55 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [cPP] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v56 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] + [cPP] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v57 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] + [cPP] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v58 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v59 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v60 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v61 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v62 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v63 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v64 (ErbB1:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k4b kd4 [(ErbB1:ErbB2)_P:GAP:Grb2] + [cPP] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:cPP];  
 
 v65 (ErbB1:ErbB3)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k4b kd4 [(ErbB1:ErbB3)_P:GAP:Grb2] + [cPP] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:cPP];  
 
 v66 (ErbB1:ErbB4)#P:GAP:Grb2 + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k4b kd4 [(ErbB1:ErbB4)_P:GAP:Grb2] + [cPP] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:cPP];  
 
 v67 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v68 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v69 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v70 (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4 [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v71 (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4 [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v72 (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4 kd4 [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v75 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4 [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] + [cPP] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:cPP];  
 
 v76 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k4b kd4 [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] + [cPP] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:cPP];  
 
 v77 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + cPP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k4b kd4 [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] + [cPP] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:cPP];  
 
 v78 2(ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 [2(ErbB2)_P:GAP:(Shc_P):Grb2] + [cPP] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v79 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [cPP] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v80 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v81 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v82 2(ErbB2)#P:GAP:Grb2 + cPP -> 2(ErbB2)#P:GAP:Grb2:cPP k4b kd4 [2(ErbB2)_P:GAP:Grb2] + [cPP] ↔ [2(ErbB2)_P:GAP:Grb2:cPP];  
 
 v83 2(ErbB2)#P:GAP:Grb2:Sos + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4 [2(ErbB2)_P:GAP:Grb2:Sos] + [cPP] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:cPP];  
 
 v84 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v85 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4 [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v87 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2] + [cPP] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v88 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k4b kd4 [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2] + [cPP] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v89 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [cPP] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v90 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v91 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v92 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v93 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k4b kd4 [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v94 (ErbB3:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k4b kd4 [(ErbB3:ErbB2)_P:GAP:Grb2] + [cPP] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:cPP];  
 
 v95 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k4b kd4 [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [cPP] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v96 (ErbB4:ErbB2)#P:GAP:Grb2 + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k4b kd4 [(ErbB4:ErbB2)_P:GAP:Grb2] + [cPP] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:cPP];  
 
 v97 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4 [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] + [cPP] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:cPP];  
 
 v98 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k4b kd4 [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] + [cPP] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:cPP];  
 
 v99 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v100 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k4b kd4 [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)] + [cPP] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v101 (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4 [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v102 (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) + cPP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k4b kd4 [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v103 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b [cPP] + [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v104 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5b kd5b [cPP] + [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v105 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b [cPP] + [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v106 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5b kd5b [cPP] + [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v107 cPP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b [cPP] + [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:cPP];  
 
 v108 cPP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:cPP k5b kd5b [cPP] + [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:cPP];  
 
 v109 cPP + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:cPP k5b kd5b [cPP] + [(ErbB4:ErbB2)_P:GAP:Grb2] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:cPP];  
 
 v110 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b [cPP] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v111 cPP + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:cPP k5b kd5b [cPP] + [(ErbB3:ErbB2)_P:GAP:Grb2] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:cPP];  
 
 v112 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b [cPP] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v113 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5b kd5b [cPP] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v114 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b [cPP] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v115 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5b kd5b [cPP] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v116 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5b kd5b [cPP] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v117 cPP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b [cPP] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v118 cPP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5b kd5b [cPP] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v120 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b [cPP] + [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v121 cPP + 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b [cPP] + [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v122 cPP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b [cPP] + [2(ErbB2)_P:GAP:Grb2:Sos] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:cPP];  
 
 v123 cPP + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:cPP k5 kd5b [cPP] + [2(ErbB2)_P:GAP:Grb2] ↔ [2(ErbB2)_P:GAP:Grb2:cPP];  
 
 v124 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b [cPP] + [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v125 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b [cPP] + [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v126 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b [cPP] + [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v127 cPP + 2(ErbB2)#P:GAP:(Shc#P):Grb2 -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b [cPP] + [2(ErbB2)_P:GAP:(Shc_P):Grb2] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v128 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:cPP k5 kd5b [cPP] + [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:cPP];  
 
 v129 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:cPP k5 kd5b [cPP] + [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:cPP];  
 
 v130 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:cPP k5 kd5b [cPP] + [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:cPP];  
 
 v133 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v134 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v135 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v136 cPP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v137 cPP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v138 cPP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v139 cPP + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:cPP k5 kd5b [cPP] + [(ErbB1:ErbB4)_P:GAP:Grb2] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:cPP];  
 
 v140 cPP + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:cPP k5 kd5b [cPP] + [(ErbB1:ErbB3)_P:GAP:Grb2] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:cPP];  
 
 v141 cPP + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:cPP k5 kd5b [cPP] + [(ErbB1:ErbB2)_P:GAP:Grb2] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:cPP];  
 
 v142 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v143 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v144 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v145 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v146 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v147 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5b [cPP] + [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v148 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b [cPP] + [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v149 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b [cPP] + [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v150 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5b [cPP] + [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v151 cPP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b [cPP] + [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v152 cPP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b [cPP] + [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v153 cPP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:cPP k5 kd5b [cPP] + [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v155 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) + cPP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP):cPP k5 kd5 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP):cPP];  
 
 v156 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP):cPP k5 kd5 [cPP] + [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP):cPP];  
 
 v157 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:cPP k5 kd5 [cPP] + [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:cPP];  
 
 v158 cPP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:cPP k5 kd5 [cPP] + [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:cPP];  
 
 v159 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP):cPP k5 kd5 [cPP] + [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP):cPP];  
 
 v160 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP):cPP k5 kd5 [cPP] + [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP):cPP];  
 
 v161 2(EGF:ErbB1)#P:GAP:Grb2 + cPP -> 2(EGF:ErbB1)#P:GAP:Grb2:cPP k5 kd5 [2(EGF:ErbB1)_P:GAP:Grb2] + [cPP] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:cPP];  
 
 v162 cPP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:cPP k5 kd5 [cPP] + [2(EGF:ErbB1)_P:GAP:Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:cPP];  
 
 v163 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k6 kd6 [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v164 ErbB1:ATP -> ErbB1:ATP k6 kd6 [ErbB1:ATP] ↔ [ErbB1:ATP];  
 
 v165 2(EGF:ErbB1)#P -> 2(EGF:ErbB1)#P k6 kd6 [2(EGF:ErbB1)_P] ↔ [2(EGF:ErbB1)_P];  
 
 v166 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP k6 kd6 [2(EGF:ErbB1)_P:GAP] ↔ [2(EGF:ErbB1)_P:GAP];  
 
 v167 2(EGF:ErbB1)#P:GAP:Shc -> 2(EGF:ErbB1)#P:GAP:Shc k6 kd6 [2(EGF:ErbB1)_P:GAP:Shc] ↔ [2(EGF:ErbB1)_P:GAP:Shc];  
 
 v168 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P) k6 kd6 [2(EGF:ErbB1)_P:GAP:(Shc_P)] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P)];  
 
 v169 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k6 kd6 [2(EGF:ErbB1)_P:GAP:Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos];  
 
 v170 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k6 kd6 [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v171 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k6 kd6 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2];  
 
 v172 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos k6 kd6 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos];  
 
 v173 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k6 kd6 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v174 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k6 kd6 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v175 2(EGF:ErbB1)#P:GAP:Grb2 + -> 2(EGF:ErbB1)#P:GAP:Grb2 k6 kd6 [2(EGF:ErbB1)_P:GAP:Grb2] ↔ [2(EGF:ErbB1)_P:GAP:Grb2];  
 
 v176 ErbB3 -> ErbB3 k6b kd6b [ErbB3] ↔ [ErbB3];  
 
 v177 ErbB2 -> ErbB2 k6b kd6b [ErbB2] ↔ [ErbB2];  
 
 v178 ErbB4 -> ErbB4 k6b kd6b [ErbB4] ↔ [ErbB4];  
 
 v179 (ErbB3:ErbB2)#P:GAP:Shc ->(ErbB3:ErbB2)#P:GAP:Shc k6b kd6b [(ErbB3:ErbB2)_P:GAP:Shc] ↔ [(ErbB3:ErbB2)_P:GAP:Shc];  
 
 v180 (ErbB4:ErbB2)#P:GAP:Shc -> (ErbB4:ErbB2)#P:GAP:Shc k6 kd6 [(ErbB4:ErbB2)_P:GAP:Shc] ↔ [(ErbB4:ErbB2)_P:GAP:Shc];  
 
 v181 (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P) k6b kd6b [(ErbB3:ErbB2)_P:GAP:(Shc_P)] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P)];  
 
 v182 ErbB2:Inh -> ErbB2:Inh k6b kd6b [ErbB2:Inh] ↔ [ErbB2:Inh];  
 
 v183 ErbB4:Inh -> ErbB4:Inh k6b kd6b [ErbB4:Inh] ↔ [ErbB4:Inh];  
 
 v184 (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P) k6b kd6b [(ErbB4:ErbB2)_P:GAP:(Shc_P)] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P)];  
 
 v185 (ErbB1:ErbB2)#P -> (ErbB1:ErbB2)#P k7 kd7 [(ErbB1:ErbB2)_P] ↔ [(ErbB1:ErbB2)_P];  
 
 v186 (ErbB1:ErbB3)#P -> (ErbB1:ErbB3)#P k7 kd7 [(ErbB1:ErbB3)_P] ↔ [(ErbB1:ErbB3)_P];  
 
 v187 (ErbB1:ErbB4)#P -> (ErbB1:ErbB4)#P k7 kd7 [(ErbB1:ErbB4)_P] ↔ [(ErbB1:ErbB4)_P];  
 
 v188 2(ErbB2)#P -> 2(ErbB2)#P k7 kd7 [2(ErbB2)_P] ↔ [2(ErbB2)_P];  
 
 v189 (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P k7 kd7 [(ErbB3:ErbB2)_P] ↔ [(ErbB3:ErbB2)_P];  
 
 v190 (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P k7 kd7 [(ErbB4:ErbB2)_P] ↔ [(ErbB4:ErbB2)_P];  
 
 v191 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP k7 kd7 [2(ErbB2)_P:GAP] ↔ [2(ErbB2)_P:GAP];  
 
 v192 2(ErbB2)#P:GAP:Shc -> 2(ErbB2)#P:GAP:Shc k7 kd7 [2(ErbB2)_P:GAP:Shc] ↔ [2(ErbB2)_P:GAP:Shc];  
 
 v193 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P) k7 kd7 [2(ErbB2)_P:GAP:(Shc_P)] ↔ [2(ErbB2)_P:GAP:(Shc_P)];  
 
 v194 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8b kd8b [(ErbB1:ErbB2)_P] + [GAP] ↔ [(ErbB1:ErbB2)_P:GAP];  
 
 v195 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b [(ErbB1:ErbB3)_P] + [GAP] ↔ [(ErbB1:ErbB3)_P:GAP];  
 
 v196 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b [(ErbB1:ErbB4)_P] + [GAP] ↔ [(ErbB1:ErbB4)_P:GAP];  
 
 v197 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8 [2(EGF:ErbB1)_P] + [GAP] ↔ [2(EGF:ErbB1)_P:GAP];  
 
 v198 2(EGF:ErbB1)#P + GAP -> 2(EGF:ErbB1)#P:GAP k8 kd8 [2(EGF:ErbB1)_P] + [GAP] ↔ [2(EGF:ErbB1)_P:GAP];  
 
 v199 (ErbB1:ErbB2)#P + GAP -> (ErbB1:ErbB2)#P:GAP k8 kd8 [(ErbB1:ErbB2)_P] + [GAP] ↔ [(ErbB1:ErbB2)_P:GAP];  
 
 v200 (ErbB1:ErbB3)#P + GAP -> (ErbB1:ErbB3)#P:GAP k8b kd8b [(ErbB1:ErbB3)_P] + [GAP] ↔ [(ErbB1:ErbB3)_P:GAP];  
 
 v201 (ErbB1:ErbB4)#P + GAP -> (ErbB1:ErbB4)#P:GAP k8b kd8b [(ErbB1:ErbB4)_P] + [GAP] ↔ [(ErbB1:ErbB4)_P:GAP];  
 
 v202 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8 [GAP] + [(ErbB3:ErbB2)_P] ↔ [(ErbB3:ErbB2)_P:GAP];  
 
 v203 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8 [GAP] + [(ErbB4:ErbB2)_P] ↔ [(ErbB4:ErbB2)_P:GAP];  
 
 v204 GAP + (ErbB3:ErbB2)#P -> (ErbB3:ErbB2)#P:GAP k8 kd8 [GAP] + [(ErbB3:ErbB2)_P] ↔ [(ErbB3:ErbB2)_P:GAP];  
 
 v205 GAP + (ErbB4:ErbB2)#P -> (ErbB4:ErbB2)#P:GAP k8 kd8 [GAP] + [(ErbB4:ErbB2)_P] ↔ [(ErbB4:ErbB2)_P:GAP];  
 
 v206 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8 [2(ErbB2)_P] + [GAP] ↔ [2(ErbB2)_P:GAP];  
 
 v207 2(ErbB2)#P + GAP -> 2(ErbB2)#P:GAP k8 kd8 [2(ErbB2)_P] + [GAP] ↔ [2(ErbB2)_P:GAP];  
 
 v208 ErbB1:ATP + EGF -> EGF:ErbB1:ATP k10b kd10 [ErbB1:ATP] + [EGF] ↔ [EGF:ErbB1:ATP];  
 
 v209 ErbB3 + -> (HRG:ErbB3) k10b kd10 [ErbB3] + [HRG] ↔ [(HRG:ErbB3)];  
 
 v211 cPP + -> cPP k15 kd15 [cPP] ↔ [cPP];  
 
 v212 Grb2 + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63 [Grb2] + [2(EGF:ErbB1)_P:GAP] ↔ [2(EGF:ErbB1)_P:GAP:Grb2];  
 
 v213 Grb2 + (Shc#P) -> (Shc#P):Grb2 k16 kd24 [Grb2] + [(Shc_P)] ↔ [(Shc_P):Grb2];  
 
 v214 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [2(EGF:ErbB1)_P:GAP:(Shc_P)] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2];  
 
 v215 2(EGF:ErbB1)#P:GAP + Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2 k16 kd63 [2(EGF:ErbB1)_P:GAP] + [Grb2] ↔ [2(EGF:ErbB1)_P:GAP:Grb2];  
 
 v216 Grb2 + 2(EGF:ErbB1)#P:GAP:(Shc#P) -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [2(EGF:ErbB1)_P:GAP:(Shc_P)] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2];  
 
 v217 Grb2 + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24 [Grb2] + [(ErbB1:ErbB2)_P:GAP] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2];  
 
 v218 Grb2 + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24 [Grb2] + [(ErbB1:ErbB3)_P:GAP] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2];  
 
 v219 Grb2 + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24 [Grb2] + [(ErbB1:ErbB4)_P:GAP] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2];  
 
 v220 (ErbB1:ErbB2)#P:GAP + Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2 k16 kd24 [(ErbB1:ErbB2)_P:GAP] + [Grb2] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2];  
 
 v221 (ErbB1:ErbB3)#P:GAP + Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2 k16 kd24 [(ErbB1:ErbB3)_P:GAP] + [Grb2] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2];  
 
 v222 (ErbB1:ErbB4)#P:GAP + Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2 k16 kd24 [(ErbB1:ErbB4)_P:GAP] + [Grb2] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2];  
 
 v223 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB1:ErbB2)_P:GAP:(Shc_P)] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2];  
 
 v224 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB1:ErbB3)_P:GAP:(Shc_P)] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2];  
 
 v225 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB1:ErbB4)_P:GAP:(Shc_P)] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2];  
 
 v226 Grb2 + (ErbB1:ErbB2)#P:GAP:(Shc#P) -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB1:ErbB2)_P:GAP:(Shc_P)] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2];  
 
 v227 Grb2 + (ErbB1:ErbB3)#P:GAP:(Shc#P) -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB1:ErbB3)_P:GAP:(Shc_P)] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2];  
 
 v228 Grb2 + (ErbB1:ErbB4)#P:GAP:(Shc#P) -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB1:ErbB4)_P:GAP:(Shc_P)] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2];  
 
 v229 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [2(ErbB2)_P:GAP:(Shc_P)] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2];  
 
 v230 Grb2 + 2(ErbB2)#P:GAP:(Shc#P) -> 2(ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [2(ErbB2)_P:GAP:(Shc_P)] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2];  
 
 v231 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63 [2(ErbB2)_P:GAP] + [Grb2] ↔ [2(ErbB2)_P:GAP:Grb2];  
 
 v232 2(ErbB2)#P:GAP + Grb2 -> 2(ErbB2)#P:GAP:Grb2 k16 kd63 [2(ErbB2)_P:GAP] + [Grb2] ↔ [2(ErbB2)_P:GAP:Grb2];  
 
 v233 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB3:ErbB2)_P:GAP:(Shc_P)] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2];  
 
 v234 Grb2 + (ErbB3:ErbB2)#P:GAP:(Shc#P) -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB3:ErbB2)_P:GAP:(Shc_P)] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2];  
 
 v235 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB4:ErbB2)_P:GAP:(Shc_P)] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2];  
 
 v236 Grb2 + (ErbB4:ErbB2)#P:GAP:(Shc#P) -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2 k16 kd24 [Grb2] + [(ErbB4:ErbB2)_P:GAP:(Shc_P)] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2];  
 
 v237 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd63 [(ErbB3:ErbB2)_P:GAP] + [Grb2] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2];  
 
 v238 (ErbB3:ErbB2)#P:GAP + Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2 k16 kd24 [(ErbB3:ErbB2)_P:GAP] + [Grb2] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2];  
 
 v239 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd24 [(ErbB4:ErbB2)_P:GAP] + [Grb2] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2];  
 
 v240 (ErbB4:ErbB2)#P:GAP + Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2 k16 kd63 [(ErbB4:ErbB2)_P:GAP] + [Grb2] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2];  
 
 v241 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB3:ErbB2)_P:GAP:Grb2] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos];  
 
 v242 Sos + (ErbB3:ErbB2)#P:GAP:Grb2 -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB3:ErbB2)_P:GAP:Grb2] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos];  
 
 v243 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB4:ErbB2)_P:GAP:Grb2] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos];  
 
 v244 Sos + (ErbB4:ErbB2)#P:GAP:Grb2 -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB4:ErbB2)_P:GAP:Grb2] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos];  
 
 v245 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [2(ErbB2)_P:GAP:Grb2] ↔ [2(ErbB2)_P:GAP:Grb2:Sos];  
 
 v246 Sos + 2(ErbB2)#P:GAP:Grb2 -> 2(ErbB2)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [2(ErbB2)_P:GAP:Grb2] ↔ [2(ErbB2)_P:GAP:Grb2:Sos];  
 
 v247 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [2(EGF:ErbB1)_P:GAP:Grb2] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos];  
 
 v248 Sos + 2(EGF:ErbB1)#P:GAP:Grb2 -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [2(EGF:ErbB1)_P:GAP:Grb2] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos];  
 
 v249 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB1:ErbB2)_P:GAP:Grb2] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos];  
 
 v250 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB1:ErbB3)_P:GAP:Grb2] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos];  
 
 v251 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB1:ErbB4)_P:GAP:Grb2] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos];  
 
 v252 Sos + (ErbB1:ErbB2)#P:GAP:Grb2 -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB1:ErbB2)_P:GAP:Grb2] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos];  
 
 v253 Sos + (ErbB1:ErbB3)#P:GAP:Grb2 -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB1:ErbB3)_P:GAP:Grb2] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos];  
 
 v254 Sos + (ErbB1:ErbB4)#P:GAP:Grb2 -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos k17 kd17 [Sos] + [(ErbB1:ErbB4)_P:GAP:Grb2] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos];  
 
 v255 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [2(EGF:ErbB1)_P:GAP:Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v256 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v257 Ras:GDP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [2(EGF:ErbB1)_P:GAP:Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v258 Ras:GDP + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v259 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v260 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v261 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v262 Ras:GDP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v263 Ras:GDP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v264 Ras:GDP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v265 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v266 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v267 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v268 Ras:GDP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v269 Ras:GDP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v270 Ras:GDP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v271 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v272 Ras:GDP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v273 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [2(ErbB2)_P:GAP:Grb2:Sos] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v274 Ras:GDP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [2(ErbB2)_P:GAP:Grb2:Sos] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v275 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v276 Ras:GDP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v277 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v278 Ras:GDP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v279 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v280 Ras:GDP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v281 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v282 Ras:GDP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k18 kd18 [Ras:GDP] + [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v283 Ras:GTP + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v284 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [(Ras:GTP)_i] + [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v285 Ras:GTP + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v286 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [(Ras:GTP)_i] + [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v287 Ras:GTP + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [2(ErbB2)_P:GAP:Grb2:Sos] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v288 (Ras:GTP)_i + 2(ErbB2)#P:GAP:Grb2:Sos -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [(Ras:GTP)_i] + [2(ErbB2)_P:GAP:Grb2:Sos] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v289 Ras:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v290 (Ras:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [(Ras:GTP)_i] + [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v291 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] + [(Ras:GTP)_i] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v292 (Ras:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [(Ras:GTP)_i] + [2(EGF:ErbB1)_P:GAP:Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v293 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GTP] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v294 Ras:GTP + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [2(EGF:ErbB1)_P:GAP:Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v295 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GTP] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v296 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GTP] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v297 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GTP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GTP] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v298 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [(Ras:GTP)_i] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v299 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] + [(Ras:GTP)_i] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v300 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] + [(Ras:GTP)_i] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v301 Ras:GTP + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v302 Ras:GTP + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v303 Ras:GTP + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v304 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] + [(Ras:GTP)_i] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v305 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] + [(Ras:GTP)_i] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v306 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + (Ras:GTP)_i -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GDP) k19 kd19 [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] + [(Ras:GTP)_i] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GDP)];  
 
 v307 Ras:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v308 (Ras:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [(Ras:GTP)_i] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v309 Ras:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [Ras:GTP] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v310 (Ras:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GDP) k19 kd19 [(Ras:GTP)_i] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GDP)];  
 
 v311 Ras_activated:GTP + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [Ras_activated:GTP] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v312 (Ras_activated:GTP)_i + (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v313 Ras_activated:GTP + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [Ras_activated:GTP] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v314 (Ras_activated:GTP)_i + (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v315 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] + [Ras_activated:GTP] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v316 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] + [Ras_activated:GTP] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v317 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] + [Ras_activated:GTP] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v318 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v319 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v320 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v321 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [2(EGF:ErbB1)_P:GAP:Grb2:Sos] + [Ras_activated:GTP] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v322 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras_activated:GTP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] + [Ras_activated:GTP] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v323 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [2(EGF:ErbB1)_P:GAP:Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v324 (Ras_activated:GTP)_i + 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v325 Ras_activated:GTP + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [Ras_activated:GTP] + [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v326 Ras_activated:GTP + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [Ras_activated:GTP] + [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v327 Ras_activated:GTP + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [Ras_activated:GTP] + [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v328 (Ras_activated:GTP)_i + (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v329 (Ras_activated:GTP)_i + (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v330 (Ras_activated:GTP)_i + (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v331 Ras_activated:GTP + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [Ras_activated:GTP] + [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v332 (Ras_activated:GTP)_i + 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k20 kd20 [(Ras_activated:GTP)_i] + [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v333 2(ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [2(ErbB2)_P:GAP:Grb2:Sos] + [Ras_activated:GTP] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v334 2(ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [2(ErbB2)_P:GAP:Grb2:Sos] + [(Ras_activated:GTP)_i] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v335 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] + [Ras_activated:GTP] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v336 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] + [(Ras_activated:GTP)_i] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v337 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras_activated:GTP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] + [Ras_activated:GTP] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v338 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + (Ras_activated:GTP)_i -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k20 kd20 [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] + [(Ras_activated:GTP)_i] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v339 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [2(ErbB2)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v340 2(ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [2(ErbB2)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [2(ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v341 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v342 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [2(ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v343 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v344 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [2(EGF:ErbB1)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v345 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [2(EGF:ErbB1)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v346 2(EGF:ErbB1)#P:GAP:Grb2:Sos + Ras:GDP -> 2(EGF:ErbB1)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [2(EGF:ErbB1)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [2(EGF:ErbB1)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v347 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v348 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v349 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v350 (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v351 (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB3)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v352 (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB4)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v353 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v354 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v355 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v356 (ErbB1:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB2)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v357 (ErbB1:ErbB3)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB3)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB3)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB3)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v358 (ErbB1:ErbB4)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB1:ErbB4)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB1:ErbB4)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB1:ErbB4)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v359 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v360 (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB3:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v361 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v362 (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:(Shc#P):Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos] + [Ras:GDP] ↔ [(ErbB4:ErbB2)_P:GAP:(Shc_P):Grb2:Sos:(Ras:GTP)];  
 
 v363 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v364 (ErbB3:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB3:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB3:ErbB2)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB3:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v365 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v366 (ErbB4:ErbB2)#P:GAP:Grb2:Sos + Ras:GDP -> (ErbB4:ErbB2)#P:GAP:Grb2:Sos:(Ras:GTP) k21 kd21 [(ErbB4:ErbB2)_P:GAP:Grb2:Sos] + [Ras:GDP] ↔ [(ErbB4:ErbB2)_P:GAP:Grb2:Sos:(Ras:GTP)];  
 
 v367 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22 [Shc] + [2(EGF:ErbB1)_P:GAP] ↔ [2(EGF:ErbB1)_P:GAP:Shc];  
 
 v368 Shc + 2(EGF:ErbB1)#P:GAP -> 2(EGF:ErbB1)#P:GAP:Shc k22 kd22 [Shc] + [2(EGF:ErbB1)_P:GAP] ↔ [2(EGF:ErbB1)_P:GAP:Shc];  
 
 v369 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b [Shc] + [(ErbB1:ErbB2)_P:GAP] ↔ [(ErbB1:ErbB2)_P:GAP:Shc];  
 
 v370 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b [Shc] + [(ErbB1:ErbB3)_P:GAP] ↔ [(ErbB1:ErbB3)_P:GAP:Shc];  
 
 v371 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b [Shc] + [(ErbB1:ErbB4)_P:GAP] ↔ [(ErbB1:ErbB4)_P:GAP:Shc];  
 
 v372 Shc + (ErbB1:ErbB2)#P:GAP -> (ErbB1:ErbB2)#P:GAP:Shc k22 kd22b [Shc] + [(ErbB1:ErbB2)_P:GAP] ↔ [(ErbB1:ErbB2)_P:GAP:Shc];  
 
 v373 Shc + (ErbB1:ErbB3)#P:GAP -> (ErbB1:ErbB3)#P:GAP:Shc k22 kd22b [Shc] + [(ErbB1:ErbB3)_P:GAP] ↔ [(ErbB1:ErbB3)_P:GAP:Shc];  
 
 v374 Shc + (ErbB1:ErbB4)#P:GAP -> (ErbB1:ErbB4)#P:GAP:Shc k22 kd22b [Shc] + [(ErbB1:ErbB4)_P:GAP] ↔ [(ErbB1:ErbB4)_P:GAP:Shc];  
 
 v375 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b [Shc] + [2(ErbB2)_P:GAP] ↔ [2(ErbB2)_P:GAP:Shc];  
 
 v376 Shc + 2(ErbB2)#P:GAP -> 2(ErbB2)#P:GAP:Shc k22 kd22b [Shc] + [2(ErbB2)_P:GAP] ↔ [2(ErbB2)_P:GAP:Shc];  
 
 v377 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b [Shc] + [(ErbB3:ErbB2)_P:GAP] ↔ [(ErbB3:ErbB2)_P:GAP:Shc];  
 
 v378 Shc + (ErbB3:ErbB2)#P:GAP -> (ErbB3:ErbB2)#P:GAP:Shc k22 kd22b [Shc] + [(ErbB3:ErbB2)_P:GAP] ↔ [(ErbB3:ErbB2)_P:GAP:Shc];  
 
 v379 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22 [Shc] + [(ErbB4:ErbB2)_P:GAP] ↔ [(ErbB4:ErbB2)_P:GAP:Shc];  
 
 v380 Shc + (ErbB4:ErbB2)#P:GAP -> (ErbB4:ErbB2)#P:GAP:Shc k22 kd22 [Shc] + [(ErbB4:ErbB2)_P:GAP] ↔ [(ErbB4:ErbB2)_P:GAP:Shc];