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BIOMD0000000235 - Kuhn2009_EndoMesodermNetwork

 

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Reference Publication
Publication ID: 19698179
Kühn C, Wierling C, Kühn A, Klipp E, Panopoulou G, Lehrach H, Poustka AJ.
Monte Carlo analysis of an ODE Model of the Sea Urchin Endomesoderm Network.
BMC Syst Biol 2009; 3: 83
Max-Planck-Institute for Molecular Genetics, Ihnestr 63-73, 14195 Berlin, Germany. clemens.kuehn@biologie.hu-berlin.de  [more]
Model
Original Model: BIOMD0000000235.origin
Submitter: Clemens Kühn
Submission ID: MODEL2133240427
Submission Date: 12 May 2009 13:00:40 UTC
Last Modification Date: 28 Apr 2014 17:30:16 UTC
Creation Date: 15 Jan 2010 16:34:00 UTC
Encoders:  Nick Juty
   Lukas Endler
   Vijayalakshmi Chelliah
   Clemens Kühn
set #1
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
set #2
bqbiol:isVersionOf Gene Ontology regulation of endodermal cell fate specification
bqbiol:hasVersion KEGG Pathway Notch signaling pathway - Strongylocentrotus purpuratus (purple sea urchin)
KEGG Pathway Wnt signaling pathway - Strongylocentrotus purpuratus (purple sea urchin)
bqbiol:hasTaxon Taxonomy Strongylocentrotus purpuratus
set #3
bqbiol:hasVersion Gene Ontology Notch signaling pathway
Gene Ontology canonical Wnt signaling pathway
Notes

This a model from the article:
Monte Carlo analysis of an ODE Model of the Sea Urchin Endomesoderm Network.
Kühn C, Wierling C, Kühn A, Klipp E, Panopoulou G, Lehrach H, Poustka AJ. BMC Syst Biol.2009 Aug 23;3:83. 19698179,
Abstract:
BACKGROUND: Gene Regulatory Networks (GRNs) control the differentiation, specification and function of cells at the genomic level. The levels of interactions within large GRNs are of enormous depth and complexity. Details about many GRNs are emerging, but in most cases it is unknown to what extent they control a given process, i.e. the grade of completeness is uncertain. This uncertainty stems from limited experimental data, which is the main bottleneck for creating detailed dynamical models of cellular processes. Parameter estimation for each node is often infeasible for very large GRNs. We propose a method, based on random parameter estimations through Monte-Carlo simulations to measure completeness grades of GRNs. RESULTS: We developed a heuristic to assess the completeness of large GRNs, using ODE simulations under different conditions and randomly sampled parameter sets to detect parameter-invariant effects of perturbations. To test this heuristic, we constructed the first ODE model of the whole sea urchin endomesoderm GRN, one of the best studied large GRNs. We find that nearly 48% of the parameter-invariant effects correspond with experimental data, which is 65% of the expected optimal agreement obtained from a submodel for which kinetic parameters were estimated and used for simulations. Randomized versions of the model reproduce only 23.5% of the experimental data. CONCLUSION: The method described in this paper enables an evaluation of network topologies of GRNs without requiring any parameter values. The benefit of this method is exemplified in the first mathematical analysis of the complete Endomesoderm Network Model. The predictions we provide deliver candidate nodes in the network that are likely to be erroneous or miss unknown connections, which may need additional experiments to improve the network topology. This mathematical model can serve as a scaffold for detailed and more realistic models. We propose that our method can be used to assess a completeness grade of any GRN. This could be especially useful for GRNs involved in human diseases, where often the amount of connectivity is unknown and/or many genes/interactions are missing.

The paper describes several models, Mi, i=1...n, where M0 correspond to the unperturbed model and all the others correspond to the perturbed model. This model is the unperturbed model. The model reproduces figure 5 of the reference publication. The figures were generated by running 1 simulation, whereas in the paper the plotted values are the means of 800 simulations using randomly samples parameter sets. Additional information from the Author: The parameter that were randomly samples are the transcription parameters c_Proteins... and k_Proteins. The parameter were sampled from a lognormal distribution with sigma = 1.5 and mu = 0.5

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team.
For more information see the terms of use.
To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

Model
Publication ID: 19698179 Submission Date: 12 May 2009 13:00:40 UTC Last Modification Date: 28 Apr 2014 17:30:16 UTC Creation Date: 15 Jan 2010 16:34:00 UTC
Mathematical expressions
Reactions
E_Gcad_Hill_Kinetic E_Notch_Hill_Kinetic E_Otx_Hill_Kinetic E_SoxB1_Hill_Kinetic
E_SuH_Hill_Kinetic E_UMR_Hill_Kinetic E_UVAOtx_Hill_Kinetic E_UbiqSoxB1_Hill_Kinetic
E_VEGF_Hill_Kinetic E_cB_Hill_Kinetic GENE_E_Alx1_transcription GENE_E_Apobec_transcription
GENE_E_Blimp1_transcription GENE_E_Bra_transcription GENE_E_Brn_transcription GENE_E_CyP_transcription
GENE_E_Delta_transcription GENE_E_Dpt_transcription GENE_E_Dri_transcription GENE_E_ES_transcription
GENE_E_Endo16_transcription GENE_E_Erg_transcription GENE_E_Ets1_transcription GENE_E_Eve_transcription
GENE_E_Ficolin_transcription GENE_E_FoxA_transcription GENE_E_FoxB_transcription GENE_E_FoxN23_transcription
GENE_E_FoxO_transcription GENE_E_FvMo_transcription GENE_E_GataC_transcription GENE_E_GataE_transcription
GENE_E_Gcad_transcription GENE_E_Gcm_transcription GENE_E_Gelsolin_transcription GENE_E_HesC_transcription
GENE_E_Hex_transcription GENE_E_Hnf6_transcription GENE_E_Hox_transcription GENE_E_Kakapo_transcription
GENE_E_Lim_transcription GENE_E_Msp130_transcription GENE_E_MspL_transcription GENE_E_Not_transcription
GENE_E_Nrl_transcription GENE_E_OrCt_transcription GENE_E_Otx_transcription GENE_E_Pks_transcription
GENE_E_Pmar1_transcription GENE_E_Sm27_transcription GENE_E_Sm30_transcription GENE_E_Sm50_transcription
GENE_E_Snail_transcription GENE_E_SoxB1_transcription GENE_E_SoxC_transcription GENE_E_SuTx_transcription
GENE_E_TBr_transcription GENE_E_Tel_transcription GENE_E_Tgif_transcription GENE_E_VEGFR_transcription
GENE_E_Wnt8_transcription GENE_E_z13_transcription GENE_M_Alx1_transcription GENE_M_Apobec_transcription
GENE_M_Blimp1_transcription GENE_M_Bra_transcription GENE_M_Brn_transcription GENE_M_CAPK_transcription
GENE_M_CyP_transcription GENE_M_Delta_transcription GENE_M_Dpt_transcription GENE_M_Dri_transcription
GENE_M_Endo16_transcription GENE_M_Erg_transcription GENE_M_Ets1_transcription GENE_M_Eve_transcription
GENE_M_Ficolin_transcription GENE_M_FoxA_transcription GENE_M_FoxB_transcription GENE_M_FoxN23_transcription
GENE_M_FoxO_transcription GENE_M_FvMo_transcription GENE_M_GataC_transcription GENE_M_GataE_transcription
GENE_M_Gcad_transcription GENE_M_Gcm_transcription GENE_M_Gelsolin_transcription GENE_M_HesC_transcription
GENE_M_Hex_transcription GENE_M_Hnf6_transcription GENE_M_Hox_transcription GENE_M_Kakapo_transcription
GENE_M_Lim_transcription GENE_M_Msp130_transcription GENE_M_MspL_transcription GENE_M_Not_transcription
GENE_M_Nrl_transcription GENE_M_OrCt_transcription GENE_M_Otx_transcription GENE_M_Pks_transcription
GENE_M_Pmar1_transcription GENE_M_Sm27_transcription GENE_M_Sm30_transcription GENE_M_Sm50_transcription
GENE_M_Snail_transcription GENE_M_SoxB1_transcription GENE_M_SoxC_transcription GENE_M_SuTx_transcription
GENE_M_TBr_transcription GENE_M_Tel_transcription GENE_M_Tgif_transcription GENE_M_VEGFR_transcription
GENE_M_Wnt8_transcription GENE_M_z13_transcription GENE_P_Alx1_transcription GENE_P_Apobec_transcription
GENE_P_Blimp1_transcription GENE_P_Bra_transcription GENE_P_Brn_transcription GENE_P_CyP_transcription
GENE_P_Delta_transcription GENE_P_Dpt_transcription GENE_P_Dri_transcription GENE_P_Endo16_transcription
GENE_P_Erg_transcription GENE_P_Ets1_transcription GENE_P_Eve_transcription GENE_P_Ficolin_transcription
GENE_P_FoxA_transcription GENE_P_FoxB_transcription GENE_P_FoxN23_transcription GENE_P_FoxO_transcription
GENE_P_FvMo_transcription GENE_P_GataC_transcription GENE_P_GataE_transcription GENE_P_Gcad_transcription
GENE_P_Gcm_transcription GENE_P_Gelsolin_transcription GENE_P_HesC_transcription GENE_P_Hex_transcription
GENE_P_Hnf6_transcription GENE_P_Hox_transcription GENE_P_Kakapo_transcription GENE_P_Lim_transcription
GENE_P_Msp130_transcription GENE_P_MspL_transcription GENE_P_Not_transcription GENE_P_Nrl_transcription
GENE_P_OrCt_transcription GENE_P_Otx_transcription GENE_P_Pks_transcription GENE_P_Pmar1_transcription
GENE_P_Sm27_transcription GENE_P_Sm30_transcription GENE_P_Sm50_transcription GENE_P_Snail_transcription
GENE_P_SoxB1_transcription GENE_P_SoxC_transcription GENE_P_SuTx_transcription GENE_P_TBr_transcription
GENE_P_Tel_transcription GENE_P_Tgif_transcription GENE_P_VEGFR_transcription GENE_P_Wnt8_transcription
GENE_P_z13_transcription M_Gcad_Hill_Kinetic M_Notch_Hill_Kinetic M_Otx_Hill_Kinetic
M_SoxB1_Hill_Kinetic M_SuH_Hill_Kinetic M_UMADelta_Hill_Kinetic M_UMANrl_Hill_Kinetic
M_UMR_Hill_Kinetic M_UbiqSoxB1_Hill_Kinetic M_cB_Hill_Kinetic PROTEIN_E_Alx1_degradation
PROTEIN_E_Apobec_degradation PROTEIN_E_Blimp1_degradation PROTEIN_E_Bra_degradation PROTEIN_E_Brn_degradation
PROTEIN_E_CAPK_degradation PROTEIN_E_CyP_degradation PROTEIN_E_Delta_activation PROTEIN_E_Delta_degradation
PROTEIN_E_Delta_inactivation PROTEIN_E_Dpt_degradation PROTEIN_E_Dri_degradation PROTEIN_E_ES_degradation
PROTEIN_E_Endo16_degradation PROTEIN_E_Erg_degradation PROTEIN_E_Ets1_degradation PROTEIN_E_Eve_degradation
PROTEIN_E_Ficolin_degradation PROTEIN_E_FoxA_degradation PROTEIN_E_FoxB_degradation PROTEIN_E_FoxN23_degradation
PROTEIN_E_FoxO_degradation PROTEIN_E_FvMo_degradation PROTEIN_E_GSK3_i_activation PROTEIN_E_GSK3_i_inactivation
PROTEIN_E_GataC_degradation PROTEIN_E_GataE_degradation PROTEIN_E_Gcad_degradation PROTEIN_E_Gcm_degradation
PROTEIN_E_Gelsolin_degradation PROTEIN_E_GroTCF_accociation PROTEIN_E_GroTCF_dissociation PROTEIN_E_HesC_degradation
PROTEIN_E_Hex_degradation PROTEIN_E_Hnf6_degradation PROTEIN_E_Hox_degradation PROTEIN_E_Kakapo_degradation
PROTEIN_E_Lim_degradation PROTEIN_E_Msp130_degradation PROTEIN_E_MspL_degradation PROTEIN_E_Not_degradation
PROTEIN_E_Notch_activation PROTEIN_E_Notch_degradation PROTEIN_E_Notch_inactivation PROTEIN_E_Nrl_degradation
PROTEIN_E_OrCt_degradation PROTEIN_E_Otx_degradation PROTEIN_E_Pks_degradation PROTEIN_E_Pmar1_degradation
PROTEIN_E_Sm27_degradation PROTEIN_E_Sm30_degradation PROTEIN_E_Sm50_degradation PROTEIN_E_Snail_degradation
PROTEIN_E_SoxB1_degradation PROTEIN_E_SoxC_degradation PROTEIN_E_SuHN_accociation PROTEIN_E_SuHN_dissociation
PROTEIN_E_SuH_degradation PROTEIN_E_SuTx_degradation PROTEIN_E_TBr_degradation PROTEIN_E_Tel_degradation
PROTEIN_E_Tgif_degradation PROTEIN_E_UMR_degradation PROTEIN_E_UVAOtx_degradation PROTEIN_E_UbiqSoxB1_degradation
PROTEIN_E_VEGFR_degradation PROTEIN_E_VEGFSignal_accociation PROTEIN_E_VEGFSignal_dissociation PROTEIN_E_VEGF_degradation
PROTEIN_E_Wnt8_degradation PROTEIN_E_cB_a_degradation PROTEIN_E_cB_degradation PROTEIN_E_frizzled_a_activation
PROTEIN_E_frizzled_a_inactivation PROTEIN_E_nBTCF_accociation PROTEIN_E_nBTCF_dissociation PROTEIN_E_z13_degradation
PROTEIN_M_Alx1_degradation PROTEIN_M_Apobec_degradation PROTEIN_M_Blimp1_degradation PROTEIN_M_Bra_degradation
PROTEIN_M_Brn_degradation PROTEIN_M_CAPK_degradation PROTEIN_M_CyP_degradation PROTEIN_M_Delta_activation
PROTEIN_M_Delta_degradation PROTEIN_M_Delta_inactivation PROTEIN_M_Dpt_degradation PROTEIN_M_Dri_degradation
PROTEIN_M_Endo16_degradation PROTEIN_M_Erg_degradation PROTEIN_M_Ets1_degradation PROTEIN_M_Eve_degradation
PROTEIN_M_Ficolin_degradation PROTEIN_M_FoxA_degradation PROTEIN_M_FoxB_degradation PROTEIN_M_FoxN23_degradation
PROTEIN_M_FoxO_degradation PROTEIN_M_FvMo_degradation PROTEIN_M_GSK3_i_activation PROTEIN_M_GSK3_i_inactivation
PROTEIN_M_GataC_degradation PROTEIN_M_GataE_degradation PROTEIN_M_Gcad_degradation PROTEIN_M_Gcm_degradation
PROTEIN_M_Gelsolin_degradation PROTEIN_M_GroTCF_accociation PROTEIN_M_GroTCF_dissociation PROTEIN_M_HesC_degradation
PROTEIN_M_Hex_degradation PROTEIN_M_Hnf6_degradation PROTEIN_M_Hox_degradation PROTEIN_M_Kakapo_degradation
PROTEIN_M_Lim_degradation PROTEIN_M_Msp130_degradation PROTEIN_M_MspL_degradation PROTEIN_M_Not_degradation
PROTEIN_M_Notch_activation PROTEIN_M_Notch_degradation PROTEIN_M_Notch_inactivation PROTEIN_M_Nrl_degradation
PROTEIN_M_OrCt_degradation PROTEIN_M_Otx_degradation PROTEIN_M_Pks_degradation PROTEIN_M_Pmar1_degradation
PROTEIN_M_Sm27_degradation PROTEIN_M_Sm30_degradation PROTEIN_M_Sm50_degradation PROTEIN_M_Snail_degradation
PROTEIN_M_SoxB1_degradation PROTEIN_M_SoxC_degradation PROTEIN_M_SuHN_accociation PROTEIN_M_SuHN_dissociation
PROTEIN_M_SuH_degradation PROTEIN_M_SuTx_degradation PROTEIN_M_TBr_degradation PROTEIN_M_Tel_degradation
PROTEIN_M_Tgif_degradation PROTEIN_M_UMADelta_degradation PROTEIN_M_UMANrl_degradation PROTEIN_M_UMR_degradation
PROTEIN_M_UbiqSoxB1_degradation PROTEIN_M_VEGFR_degradation PROTEIN_M_VEGFSignal_accociation PROTEIN_M_VEGFSignal_dissociation
PROTEIN_M_Wnt8_degradation PROTEIN_M_cB_a_degradation PROTEIN_M_cB_degradation PROTEIN_M_frizzled_a_activation
PROTEIN_M_frizzled_a_inactivation PROTEIN_M_nBTCF_accociation PROTEIN_M_nBTCF_dissociation PROTEIN_M_z13_degradation
PROTEIN_P_Alx1_degradation PROTEIN_P_Apobec_degradation PROTEIN_P_Blimp1_degradation PROTEIN_P_Bra_degradation
PROTEIN_P_Brn_degradation PROTEIN_P_CAPK_degradation PROTEIN_P_CyP_degradation PROTEIN_P_Delta_activation
PROTEIN_P_Delta_degradation PROTEIN_P_Delta_inactivation PROTEIN_P_Dpt_degradation PROTEIN_P_Dri_degradation
PROTEIN_P_Endo16_degradation PROTEIN_P_Erg_degradation PROTEIN_P_Ets1_degradation PROTEIN_P_Eve_degradation
PROTEIN_P_Ficolin_degradation PROTEIN_P_FoxA_degradation PROTEIN_P_FoxB_degradation PROTEIN_P_FoxN23_degradation
PROTEIN_P_FoxO_degradation PROTEIN_P_FvMo_degradation PROTEIN_P_GSK3_i_activation PROTEIN_P_GSK3_i_inactivation
PROTEIN_P_GataC_degradation PROTEIN_P_GataE_degradation PROTEIN_P_Gcad_degradation PROTEIN_P_Gcm_degradation
PROTEIN_P_Gelsolin_degradation PROTEIN_P_GroTCF_accociation PROTEIN_P_GroTCF_dissociation PROTEIN_P_HesC_degradation
PROTEIN_P_Hex_degradation PROTEIN_P_Hnf6_degradation PROTEIN_P_Hox_degradation PROTEIN_P_Kakapo_degradation
PROTEIN_P_L1_degradation PROTEIN_P_Lim_degradation PROTEIN_P_Msp130_degradation PROTEIN_P_MspL_degradation
PROTEIN_P_Not_degradation PROTEIN_P_Notch_activation PROTEIN_P_Notch_inactivation PROTEIN_P_Nrl_degradation
PROTEIN_P_OrCt_degradation PROTEIN_P_Otx_degradation PROTEIN_P_Pks_degradation PROTEIN_P_Pmar1_degradation
PROTEIN_P_Sm27_degradation PROTEIN_P_Sm30_degradation PROTEIN_P_Sm50_degradation PROTEIN_P_Snail_degradation
PROTEIN_P_SoxB1_degradation PROTEIN_P_SoxC_degradation PROTEIN_P_SuHN_accociation PROTEIN_P_SuHN_dissociation
PROTEIN_P_SuTx_degradation PROTEIN_P_TBr_degradation PROTEIN_P_Tel_degradation PROTEIN_P_Tgif_degradation
PROTEIN_P_UbiqAlx1_degradation PROTEIN_P_UbiqES_degradation PROTEIN_P_UbiqEts1_degradation PROTEIN_P_UbiqHesC_degradation
PROTEIN_P_UbiqHnf6_degradation PROTEIN_P_UbiqSoxC_degradation PROTEIN_P_UbiqTel_degradation PROTEIN_P_VEGFR_degradation
PROTEIN_P_VEGFSignal_accociation PROTEIN_P_VEGFSignal_dissociation PROTEIN_P_Wnt8_degradation PROTEIN_P_cB_a_degradation
PROTEIN_P_cB_degradation PROTEIN_P_frizzled_a_activation PROTEIN_P_frizzled_a_inactivation PROTEIN_P_nBTCF_accociation
PROTEIN_P_nBTCF_dissociation PROTEIN_P_z13_degradation P_Ets1_Hill_Kinetic P_Gcad_Hill_Kinetic
P_L1_Hill_Kinetic P_Otx_Hill_Kinetic P_UbiqAlx1_Hill_Kinetic P_UbiqES_Hill_Kinetic
P_UbiqEts1_Hill_Kinetic P_UbiqHesC_Hill_Kinetic P_UbiqHnf6_Hill_Kinetic P_UbiqSoxC_Hill_Kinetic
P_UbiqTel_Hill_Kinetic P_cB_Hill_Kinetic mRNA_E_Alx1_degradation mRNA_E_Alx1_translation
mRNA_E_Apobec_degradation mRNA_E_Apobec_translation mRNA_E_Blimp1_degradation mRNA_E_Blimp1_translation
mRNA_E_Bra_degradation mRNA_E_Bra_translation mRNA_E_Brn_degradation mRNA_E_Brn_translation
mRNA_E_CAPK_degradation mRNA_E_CAPK_translation mRNA_E_CyP_degradation mRNA_E_CyP_translation
mRNA_E_Delta_degradation mRNA_E_Delta_translation mRNA_E_Dpt_degradation mRNA_E_Dpt_translation
mRNA_E_Dri_degradation mRNA_E_Dri_translation mRNA_E_ES_degradation mRNA_E_ES_translation
mRNA_E_Endo16_degradation mRNA_E_Endo16_translation mRNA_E_Erg_degradation mRNA_E_Erg_translation
mRNA_E_Ets1_degradation mRNA_E_Ets1_translation mRNA_E_Eve_degradation mRNA_E_Eve_translation
mRNA_E_Ficolin_degradation mRNA_E_Ficolin_translation mRNA_E_FoxA_degradation mRNA_E_FoxA_translation
mRNA_E_FoxB_degradation mRNA_E_FoxB_translation mRNA_E_FoxN23_degradation mRNA_E_FoxN23_translation
mRNA_E_FoxO_degradation mRNA_E_FoxO_translation mRNA_E_FvMo_degradation mRNA_E_FvMo_translation
mRNA_E_GataC_degradation mRNA_E_GataC_translation mRNA_E_GataE_degradation mRNA_E_GataE_translation
mRNA_E_Gcad_degradation mRNA_E_Gcad_translation mRNA_E_Gcm_degradation mRNA_E_Gcm_translation
mRNA_E_Gelsolin_degradation mRNA_E_Gelsolin_translation mRNA_E_HesC_degradation mRNA_E_HesC_translation
mRNA_E_Hex_degradation mRNA_E_Hex_translation mRNA_E_Hnf6_degradation mRNA_E_Hnf6_translation
mRNA_E_Hox_degradation mRNA_E_Hox_translation mRNA_E_Kakapo_degradation mRNA_E_Kakapo_translation
mRNA_E_Lim_degradation mRNA_E_Lim_translation mRNA_E_Msp130_degradation mRNA_E_Msp130_translation
mRNA_E_MspL_degradation mRNA_E_MspL_translation mRNA_E_Not_degradation mRNA_E_Not_translation
mRNA_E_Notch_degradation mRNA_E_Notch_translation mRNA_E_Nrl_degradation mRNA_E_Nrl_translation
mRNA_E_OrCt_degradation mRNA_E_OrCt_translation mRNA_E_Otx_degradation mRNA_E_Otx_translation
mRNA_E_Pks_degradation mRNA_E_Pks_translation mRNA_E_Pmar1_degradation mRNA_E_Pmar1_translation
mRNA_E_Sm27_degradation mRNA_E_Sm27_translation mRNA_E_Sm30_degradation mRNA_E_Sm30_translation
mRNA_E_Sm50_degradation mRNA_E_Sm50_translation mRNA_E_Snail_degradation mRNA_E_Snail_translation
mRNA_E_SoxB1_degradation mRNA_E_SoxB1_translation mRNA_E_SoxC_degradation mRNA_E_SoxC_translation
mRNA_E_SuH_degradation mRNA_E_SuH_translation mRNA_E_SuTx_degradation mRNA_E_SuTx_translation
mRNA_E_TBr_degradation mRNA_E_TBr_translation mRNA_E_Tel_degradation mRNA_E_Tel_translation
mRNA_E_Tgif_degradation mRNA_E_Tgif_translation mRNA_E_UMR_degradation mRNA_E_UMR_translation
mRNA_E_UVAOtx_degradation mRNA_E_UVAOtx_translation mRNA_E_UbiqSoxB1_degradation mRNA_E_UbiqSoxB1_translation
mRNA_E_VEGFR_degradation mRNA_E_VEGFR_translation mRNA_E_VEGF_degradation mRNA_E_VEGF_translation
mRNA_E_Wnt8_degradation mRNA_E_Wnt8_translation mRNA_E_cB_degradation mRNA_E_cB_translation
mRNA_E_z13_degradation mRNA_E_z13_translation mRNA_M_Alx1_degradation mRNA_M_Alx1_translation
mRNA_M_Apobec_degradation mRNA_M_Apobec_translation mRNA_M_Blimp1_degradation mRNA_M_Blimp1_translation
mRNA_M_Bra_degradation mRNA_M_Bra_translation mRNA_M_Brn_degradation mRNA_M_Brn_translation
mRNA_M_CAPK_degradation mRNA_M_CAPK_translation mRNA_M_CyP_degradation mRNA_M_CyP_translation
mRNA_M_Delta_degradation mRNA_M_Delta_translation mRNA_M_Dpt_degradation mRNA_M_Dpt_translation
mRNA_M_Dri_degradation mRNA_M_Dri_translation mRNA_M_Endo16_degradation mRNA_M_Endo16_translation
mRNA_M_Erg_degradation mRNA_M_Erg_translation mRNA_M_Ets1_degradation mRNA_M_Ets1_translation
mRNA_M_Eve_degradation mRNA_M_Eve_translation mRNA_M_Ficolin_degradation mRNA_M_Ficolin_translation
mRNA_M_FoxA_degradation mRNA_M_FoxA_translation mRNA_M_FoxB_degradation mRNA_M_FoxB_translation
mRNA_M_FoxN23_degradation mRNA_M_FoxN23_translation mRNA_M_FoxO_degradation mRNA_M_FoxO_translation
mRNA_M_FvMo_degradation mRNA_M_FvMo_translation mRNA_M_GataC_degradation mRNA_M_GataC_translation
mRNA_M_GataE_degradation mRNA_M_GataE_translation mRNA_M_Gcad_degradation mRNA_M_Gcad_translation
mRNA_M_Gcm_degradation mRNA_M_Gcm_translation mRNA_M_Gelsolin_degradation mRNA_M_Gelsolin_translation
mRNA_M_HesC_degradation mRNA_M_HesC_translation mRNA_M_Hex_degradation mRNA_M_Hex_translation
mRNA_M_Hnf6_degradation mRNA_M_Hnf6_translation mRNA_M_Hox_degradation mRNA_M_Hox_translation
mRNA_M_Kakapo_degradation mRNA_M_Kakapo_translation mRNA_M_Lim_degradation mRNA_M_Lim_translation
mRNA_M_Msp130_degradation mRNA_M_Msp130_translation mRNA_M_MspL_degradation mRNA_M_MspL_translation
mRNA_M_Not_degradation mRNA_M_Not_translation mRNA_M_Notch_degradation mRNA_M_Notch_translation
mRNA_M_Nrl_degradation mRNA_M_Nrl_translation mRNA_M_OrCt_degradation mRNA_M_OrCt_translation
mRNA_M_Otx_degradation mRNA_M_Otx_translation mRNA_M_Pks_degradation mRNA_M_Pks_translation
mRNA_M_Pmar1_degradation mRNA_M_Pmar1_translation mRNA_M_Sm27_degradation mRNA_M_Sm27_translation
mRNA_M_Sm30_degradation mRNA_M_Sm30_translation mRNA_M_Sm50_degradation mRNA_M_Sm50_translation
mRNA_M_Snail_degradation mRNA_M_Snail_translation mRNA_M_SoxB1_degradation mRNA_M_SoxB1_translation
mRNA_M_SoxC_degradation mRNA_M_SoxC_translation mRNA_M_SuH_degradation mRNA_M_SuH_translation
mRNA_M_SuTx_degradation mRNA_M_SuTx_translation mRNA_M_TBr_degradation mRNA_M_TBr_translation
mRNA_M_Tel_degradation mRNA_M_Tel_translation mRNA_M_Tgif_degradation mRNA_M_Tgif_translation
mRNA_M_UMADelta_degradation mRNA_M_UMADelta_translation mRNA_M_UMANrl_degradation mRNA_M_UMANrl_translation
mRNA_M_UMR_degradation mRNA_M_UMR_translation mRNA_M_UbiqSoxB1_degradation mRNA_M_UbiqSoxB1_translation
mRNA_M_VEGFR_degradation mRNA_M_VEGFR_translation mRNA_M_Wnt8_degradation mRNA_M_Wnt8_translation
mRNA_M_cB_degradation mRNA_M_cB_translation mRNA_M_z13_degradation mRNA_M_z13_translation
mRNA_P_Alx1_degradation mRNA_P_Alx1_translation mRNA_P_Apobec_degradation mRNA_P_Apobec_translation
mRNA_P_Blimp1_degradation mRNA_P_Blimp1_translation mRNA_P_Bra_degradation mRNA_P_Bra_translation
mRNA_P_Brn_degradation mRNA_P_Brn_translation mRNA_P_CAPK_degradation mRNA_P_CAPK_translation
mRNA_P_CyP_degradation mRNA_P_CyP_translation mRNA_P_Delta_degradation mRNA_P_Delta_translation
mRNA_P_Dpt_degradation mRNA_P_Dpt_translation mRNA_P_Dri_degradation mRNA_P_Dri_translation
mRNA_P_Endo16_degradation mRNA_P_Endo16_translation mRNA_P_Erg_degradation mRNA_P_Erg_translation
mRNA_P_Ets1_degradation mRNA_P_Ets1_translation mRNA_P_Eve_degradation mRNA_P_Eve_translation
mRNA_P_Ficolin_degradation mRNA_P_Ficolin_translation mRNA_P_FoxA_degradation mRNA_P_FoxA_translation
mRNA_P_FoxB_degradation mRNA_P_FoxB_translation mRNA_P_FoxN23_degradation mRNA_P_FoxN23_translation
mRNA_P_FoxO_degradation mRNA_P_FoxO_translation mRNA_P_FvMo_degradation mRNA_P_FvMo_translation
mRNA_P_GataC_degradation mRNA_P_GataC_translation mRNA_P_GataE_degradation mRNA_P_GataE_translation
mRNA_P_Gcad_degradation mRNA_P_Gcad_translation mRNA_P_Gcm_degradation mRNA_P_Gcm_translation
mRNA_P_Gelsolin_degradation mRNA_P_Gelsolin_translation mRNA_P_HesC_degradation mRNA_P_HesC_translation
mRNA_P_Hex_degradation mRNA_P_Hex_translation mRNA_P_Hnf6_degradation mRNA_P_Hnf6_translation
mRNA_P_Hox_degradation mRNA_P_Hox_translation mRNA_P_Kakapo_degradation mRNA_P_Kakapo_translation
mRNA_P_L1_degradation mRNA_P_L1_translation mRNA_P_Lim_degradation mRNA_P_Lim_translation
mRNA_P_Msp130_degradation mRNA_P_Msp130_translation mRNA_P_MspL_degradation mRNA_P_MspL_translation
mRNA_P_Not_degradation mRNA_P_Not_translation mRNA_P_Nrl_degradation mRNA_P_Nrl_translation
mRNA_P_OrCt_degradation mRNA_P_OrCt_translation mRNA_P_Otx_degradation mRNA_P_Otx_translation
mRNA_P_Pks_degradation mRNA_P_Pks_translation mRNA_P_Pmar1_degradation mRNA_P_Pmar1_translation
mRNA_P_Sm27_degradation mRNA_P_Sm27_translation mRNA_P_Sm30_degradation mRNA_P_Sm30_translation
mRNA_P_Sm50_degradation mRNA_P_Sm50_translation mRNA_P_Snail_degradation mRNA_P_Snail_translation
mRNA_P_SoxB1_degradation mRNA_P_SoxB1_translation mRNA_P_SoxC_degradation mRNA_P_SoxC_translation
mRNA_P_SuTx_degradation mRNA_P_SuTx_translation mRNA_P_TBr_degradation mRNA_P_TBr_translation
mRNA_P_Tel_degradation mRNA_P_Tel_translation mRNA_P_Tgif_degradation mRNA_P_Tgif_translation
mRNA_P_UbiqAlx1_degradation mRNA_P_UbiqAlx1_translation mRNA_P_UbiqES_degradation mRNA_P_UbiqES_translation
mRNA_P_UbiqEts1_degradation mRNA_P_UbiqEts1_translation mRNA_P_UbiqHesC_degradation mRNA_P_UbiqHesC_translation
mRNA_P_UbiqHnf6_degradation mRNA_P_UbiqHnf6_translation mRNA_P_UbiqSoxC_degradation mRNA_P_UbiqSoxC_translation
mRNA_P_UbiqTel_degradation mRNA_P_UbiqTel_translation mRNA_P_VEGFR_degradation mRNA_P_VEGFR_translation
mRNA_P_Wnt8_degradation mRNA_P_Wnt8_translation mRNA_P_cB_degradation mRNA_P_cB_translation
mRNA_P_z13_degradation mRNA_P_z13_translation    
Events
e24 e21 e19 e18
e15 e12 e30 e23
e29 e20 e17 e14
e8 e11    
Physical entities
Compartments Species
default      
Compartment.outside none    
cell GENE_E_Alx1 GENE_E_Apobec GENE_E_Blimp1
GENE_E_Bra GENE_E_Brn GENE_E_CAPK
GENE_E_CyP GENE_E_Delta GENE_E_Dpt
GENE_E_Dri GENE_E_ES GENE_E_Endo16
GENE_E_Erg GENE_E_Ets1 GENE_E_Eve
GENE_E_Ficolin GENE_E_FoxA GENE_E_FoxB
GENE_E_FoxN23 GENE_E_FoxO GENE_E_FvMo
GENE_E_GataC GENE_E_GataE GENE_E_Gcad
GENE_E_Gcm GENE_E_Gelsolin GENE_E_HesC
GENE_E_Hex GENE_E_Hnf6 GENE_E_Hox
GENE_E_Kakapo GENE_E_Lim GENE_E_Msp130
GENE_E_MspL GENE_E_Not GENE_E_Nrl
GENE_E_OrCt GENE_E_Otx GENE_E_Pks
GENE_E_Pmar1 GENE_E_Sm27 GENE_E_Sm30
GENE_E_Sm50 GENE_E_Snail GENE_E_SoxB1
GENE_E_SoxC GENE_E_SuTx GENE_E_TBr
GENE_E_Tel GENE_E_Tgif GENE_E_VEGFR
GENE_E_Wnt8 GENE_E_z13 GENE_M_Alx1
GENE_M_Apobec GENE_M_Blimp1 GENE_M_Bra
GENE_M_Brn GENE_M_CAPK GENE_M_CyP
GENE_M_Delta GENE_M_Dpt GENE_M_Dri
GENE_M_Endo16 GENE_M_Erg GENE_M_Ets1
GENE_M_Eve GENE_M_Ficolin GENE_M_FoxA
GENE_M_FoxB GENE_M_FoxN23 GENE_M_FoxO
GENE_M_FvMo GENE_M_GataC GENE_M_GataE
GENE_M_Gcad GENE_M_Gcm GENE_M_Gelsolin
GENE_M_HesC GENE_M_Hex GENE_M_Hnf6
GENE_M_Hox GENE_M_Kakapo GENE_M_Lim
GENE_M_Msp130 GENE_M_MspL GENE_M_Not
GENE_M_Nrl GENE_M_OrCt GENE_M_Otx
GENE_M_Pks GENE_M_Pmar1 GENE_M_Sm27
GENE_M_Sm30 GENE_M_Sm50 GENE_M_Snail
GENE_M_SoxB1 GENE_M_SoxC GENE_M_SuTx
GENE_M_TBr GENE_M_Tel GENE_M_Tgif
GENE_M_VEGFR GENE_M_Wnt8 GENE_M_z13
GENE_P_Alx1 GENE_P_Apobec GENE_P_Blimp1
GENE_P_Bra GENE_P_Brn GENE_P_CAPK
GENE_P_CyP GENE_P_Delta GENE_P_Dpt
GENE_P_Dri GENE_P_Endo16 GENE_P_Erg
GENE_P_Ets1 GENE_P_Eve GENE_P_Ficolin
GENE_P_FoxA GENE_P_FoxB GENE_P_FoxN23
GENE_P_FoxO GENE_P_FvMo GENE_P_GataC
GENE_P_GataE GENE_P_Gcad GENE_P_Gcm
GENE_P_Gelsolin GENE_P_HesC GENE_P_Hex
GENE_P_Hnf6 GENE_P_Hox GENE_P_Kakapo
GENE_P_Lim GENE_P_Msp130 GENE_P_MspL
GENE_P_Not GENE_P_Nrl GENE_P_OrCt
GENE_P_Otx GENE_P_Pks GENE_P_Pmar1
GENE_P_Sm27 GENE_P_Sm30 GENE_P_Sm50
GENE_P_Snail GENE_P_SoxB1 GENE_P_SoxC
GENE_P_SuTx GENE_P_TBr GENE_P_Tel
GENE_P_Tgif GENE_P_VEGFR GENE_P_Wnt8
GENE_P_z13 PRE_E_Gcad PRE_E_Notch
PRE_E_Otx PRE_E_SoxB1 PRE_E_SuH
PRE_E_UMR PRE_E_UVAOtx PRE_E_UbiqSoxB1
PRE_E_VEGF PRE_E_cB PRE_M_Gcad
PRE_M_Notch PRE_M_Otx PRE_M_SoxB1
PRE_M_SuH PRE_M_UMADelta PRE_M_UMANrl
PRE_M_UMR PRE_M_UbiqSoxB1 PRE_M_cB
PRE_P_Ets1 PRE_P_Gcad PRE_P_L1
PRE_P_Otx PRE_P_UbiqAlx1 PRE_P_UbiqES
PRE_P_UbiqEts1 PRE_P_UbiqHesC PRE_P_UbiqHnf6
PRE_P_UbiqSoxC PRE_P_UbiqTel PRE_P_cB
PROTEIN_E_Alx1 PROTEIN_E_Apobec PROTEIN_E_Blimp1
PROTEIN_E_Bra PROTEIN_E_Brn PROTEIN_E_CAPK
PROTEIN_E_CyP PROTEIN_E_Delta PROTEIN_E_Delta2
PROTEIN_E_Dpt PROTEIN_E_Dri PROTEIN_E_ES
PROTEIN_E_Endo16 PROTEIN_E_Erg PROTEIN_E_Ets1
PROTEIN_E_Eve PROTEIN_E_Ficolin PROTEIN_E_FoxA
PROTEIN_E_FoxB PROTEIN_E_FoxN23 PROTEIN_E_FoxO
PROTEIN_E_FvMo PROTEIN_E_GSK3_a PROTEIN_E_GSK3_i
PROTEIN_E_GataC PROTEIN_E_GataE PROTEIN_E_Gcad
PROTEIN_E_Gcm PROTEIN_E_Gelsolin PROTEIN_E_Gro
PROTEIN_E_GroTCF PROTEIN_E_GroTFC PROTEIN_E_HesC
PROTEIN_E_Hex PROTEIN_E_Hnf6 PROTEIN_E_Hox
PROTEIN_E_Kakapo PROTEIN_E_L1 PROTEIN_E_Lim
PROTEIN_E_Msp130 PROTEIN_E_MspL PROTEIN_E_Not
PROTEIN_E_Notch PROTEIN_E_Notch2 PROTEIN_E_Nrl
PROTEIN_E_OrCt PROTEIN_E_Otx PROTEIN_E_Pks
PROTEIN_E_Pmar1 PROTEIN_E_Sm27 PROTEIN_E_Sm30
PROTEIN_E_Sm50 PROTEIN_E_Snail PROTEIN_E_SoxB1
PROTEIN_E_SoxC PROTEIN_E_SuH PROTEIN_E_SuHN
PROTEIN_E_SuTx PROTEIN_E_TBr PROTEIN_E_TCF
PROTEIN_E_Tel PROTEIN_E_Tgif PROTEIN_E_UMADelta
PROTEIN_E_UMANrl PROTEIN_E_UMR PROTEIN_E_UVAOtx
PROTEIN_E_UbiqAlx1 PROTEIN_E_UbiqDelta PROTEIN_E_UbiqES
PROTEIN_E_UbiqEts1 PROTEIN_E_UbiqGcad PROTEIN_E_UbiqHesC
PROTEIN_E_UbiqHnf6 PROTEIN_E_UbiqSoxB1 PROTEIN_E_UbiqSoxC
PROTEIN_E_UbiqTel PROTEIN_E_VEGF PROTEIN_E_VEGFR
PROTEIN_E_VEGFSignal PROTEIN_E_Wnt8 PROTEIN_E_cB
PROTEIN_E_frizzled_a PROTEIN_E_frizzled_i PROTEIN_E_nBTCF
PROTEIN_E_z13 PROTEIN_GCM PROTEIN_M_Alx1
PROTEIN_M_Apobec PROTEIN_M_Blimp1 PROTEIN_M_Bra
PROTEIN_M_Brn PROTEIN_M_CAPK PROTEIN_M_CyP
PROTEIN_M_Delta PROTEIN_M_Delta2 PROTEIN_M_Dpt
PROTEIN_M_Dri PROTEIN_M_Endo16 PROTEIN_M_Erg
PROTEIN_M_Ets1 PROTEIN_M_Eve PROTEIN_M_Ficolin
PROTEIN_M_FoxA PROTEIN_M_FoxB PROTEIN_M_FoxN23
PROTEIN_M_FoxO PROTEIN_M_FvMo PROTEIN_M_GSK3_a
PROTEIN_M_GSK3_i PROTEIN_M_GataC PROTEIN_M_GataE
PROTEIN_M_Gcad PROTEIN_M_Gcm PROTEIN_M_Gelsolin
PROTEIN_M_Gro PROTEIN_M_GroTCF PROTEIN_M_GroTFC
PROTEIN_M_HesC PROTEIN_M_Hex PROTEIN_M_Hnf6
PROTEIN_M_Hox PROTEIN_M_Kakapo PROTEIN_M_L1
PROTEIN_M_Lim PROTEIN_M_Msp130 PROTEIN_M_MspL
PROTEIN_M_Not PROTEIN_M_Notch PROTEIN_M_Notch2
PROTEIN_M_Nrl PROTEIN_M_OrCt PROTEIN_M_Otx
PROTEIN_M_Pks PROTEIN_M_Pmar1 PROTEIN_M_Sm27
PROTEIN_M_Sm30 PROTEIN_M_Sm50 PROTEIN_M_Snail
PROTEIN_M_SoxB1 PROTEIN_M_SoxC PROTEIN_M_SuH
PROTEIN_M_SuHN PROTEIN_M_SuTx PROTEIN_M_TBr
PROTEIN_M_TCF PROTEIN_M_Tel PROTEIN_M_Tgif
PROTEIN_M_UMADelta PROTEIN_M_UMANrl PROTEIN_M_UMR
PROTEIN_M_UVAOtx PROTEIN_M_UbiqAlx1 PROTEIN_M_UbiqDelta
PROTEIN_M_UbiqES PROTEIN_M_UbiqEts1 PROTEIN_M_UbiqGcad
PROTEIN_M_UbiqHesC PROTEIN_M_UbiqHnf6 PROTEIN_M_UbiqSoxB1
PROTEIN_M_UbiqSoxC PROTEIN_M_UbiqTel PROTEIN_M_VEGFR
PROTEIN_M_VEGFSignal PROTEIN_M_Wnt8 PROTEIN_M_cB
PROTEIN_M_frizzled_a PROTEIN_M_frizzled_i PROTEIN_M_nBTCF
PROTEIN_M_z13 PROTEIN_P_Alx1 PROTEIN_P_Apobec
PROTEIN_P_Blimp1 PROTEIN_P_Bra PROTEIN_P_Brn
PROTEIN_P_CAPK PROTEIN_P_CyP PROTEIN_P_Delta
PROTEIN_P_Delta2 PROTEIN_P_Dpt PROTEIN_P_Dri
PROTEIN_P_Endo16 PROTEIN_P_Erg PROTEIN_P_Ets1
PROTEIN_P_Eve PROTEIN_P_Ficolin PROTEIN_P_FoxA
PROTEIN_P_FoxB PROTEIN_P_FoxN23 PROTEIN_P_FoxO
PROTEIN_P_FvMo PROTEIN_P_GSK3_a PROTEIN_P_GSK3_i
PROTEIN_P_GataC PROTEIN_P_GataE PROTEIN_P_Gcad
PROTEIN_P_Gcm PROTEIN_P_Gelsolin PROTEIN_P_Gro
PROTEIN_P_GroTCF PROTEIN_P_GroTFC PROTEIN_P_HesC
PROTEIN_P_Hex PROTEIN_P_Hnf6 PROTEIN_P_Hox
PROTEIN_P_Kakapo PROTEIN_P_L1 PROTEIN_P_Lim
PROTEIN_P_Msp130 PROTEIN_P_MspL PROTEIN_P_Not
PROTEIN_P_Notch PROTEIN_P_Notch2 PROTEIN_P_Nrl
PROTEIN_P_OrCt PROTEIN_P_Otx PROTEIN_P_Pks
PROTEIN_P_Pmar1 PROTEIN_P_Sm27 PROTEIN_P_Sm30
PROTEIN_P_Sm50 PROTEIN_P_Snail PROTEIN_P_SoxB1
PROTEIN_P_SoxC PROTEIN_P_SuH PROTEIN_P_SuHN
PROTEIN_P_SuTx PROTEIN_P_TBr PROTEIN_P_TCF
PROTEIN_P_Tel PROTEIN_P_Tgif PROTEIN_P_UMADelta
PROTEIN_P_UMANrl PROTEIN_P_UVAOtx PROTEIN_P_UbiqAlx1
PROTEIN_P_UbiqDelta PROTEIN_P_UbiqES PROTEIN_P_UbiqEts1
PROTEIN_P_UbiqGcad PROTEIN_P_UbiqHesC PROTEIN_P_UbiqHnf6
PROTEIN_P_UbiqSoxB1 PROTEIN_P_UbiqSoxC PROTEIN_P_UbiqTel
PROTEIN_P_VEGFR PROTEIN_P_VEGFSignal PROTEIN_P_Wnt8
PROTEIN_P_cB PROTEIN_P_frizzled_a PROTEIN_P_frizzled_i
PROTEIN_P_nBTCF PROTEIN_P_z13 mRNA_E_Alx1
mRNA_E_Apobec mRNA_E_Blimp1 mRNA_E_Bra
mRNA_E_Brn mRNA_E_CAPK mRNA_E_CyP
mRNA_E_Delta mRNA_E_Dpt mRNA_E_Dri
mRNA_E_ES mRNA_E_Endo16 mRNA_E_Erg
mRNA_E_Ets1 mRNA_E_Eve mRNA_E_Ficolin
mRNA_E_FoxA mRNA_E_FoxB mRNA_E_FoxN23
mRNA_E_FoxO mRNA_E_FvMo mRNA_E_GataC
mRNA_E_GataE mRNA_E_Gcad mRNA_E_Gcm
mRNA_E_Gelsolin mRNA_E_HesC mRNA_E_Hex
mRNA_E_Hnf6 mRNA_E_Hox mRNA_E_Kakapo
mRNA_E_Lim mRNA_E_Msp130 mRNA_E_MspL
mRNA_E_Not mRNA_E_Notch mRNA_E_Nrl
mRNA_E_OrCt mRNA_E_Otx mRNA_E_Pks
mRNA_E_Pmar1 mRNA_E_Sm27 mRNA_E_Sm30
mRNA_E_Sm50 mRNA_E_Snail mRNA_E_SoxB1
mRNA_E_SoxC mRNA_E_SuH mRNA_E_SuTx
mRNA_E_TBr mRNA_E_Tel mRNA_E_Tgif
mRNA_E_UMR mRNA_E_UVAOtx mRNA_E_UbiqSoxB1
mRNA_E_VEGF mRNA_E_VEGFR mRNA_E_Wnt8
mRNA_E_cB mRNA_E_z13 mRNA_M_Alx1
mRNA_M_Apobec mRNA_M_Blimp1 mRNA_M_Bra
mRNA_M_Brn mRNA_M_CAPK mRNA_M_CyP
mRNA_M_Delta mRNA_M_Dpt mRNA_M_Dri
mRNA_M_Endo16 mRNA_M_Erg mRNA_M_Ets1
mRNA_M_Eve mRNA_M_Ficolin mRNA_M_FoxA
mRNA_M_FoxB mRNA_M_FoxN23 mRNA_M_FoxO
mRNA_M_FvMo mRNA_M_GataC mRNA_M_GataE
mRNA_M_Gcad mRNA_M_Gcm mRNA_M_Gelsolin
mRNA_M_HesC mRNA_M_Hex mRNA_M_Hnf6
mRNA_M_Hox mRNA_M_Kakapo mRNA_M_Lim
mRNA_M_Msp130 mRNA_M_MspL mRNA_M_Not
mRNA_M_Notch mRNA_M_Nrl mRNA_M_OrCt
mRNA_M_Otx mRNA_M_Pks mRNA_M_Pmar1
mRNA_M_Sm27 mRNA_M_Sm30 mRNA_M_Sm50
mRNA_M_Snail mRNA_M_SoxB1 mRNA_M_SoxC
mRNA_M_SuH mRNA_M_SuTx mRNA_M_TBr
mRNA_M_Tel mRNA_M_Tgif mRNA_M_UMADelta
mRNA_M_UMANrl mRNA_M_UMR mRNA_M_UbiqSoxB1
mRNA_M_VEGFR mRNA_M_Wnt8 mRNA_M_cB
mRNA_M_z13 mRNA_P_Alx1 mRNA_P_Apobec
mRNA_P_Blimp1 mRNA_P_Bra mRNA_P_Brn
mRNA_P_CAPK mRNA_P_CyP mRNA_P_Delta
mRNA_P_Dpt mRNA_P_Dri mRNA_P_Endo16
mRNA_P_Erg mRNA_P_Ets1 mRNA_P_Eve
mRNA_P_Ficolin mRNA_P_FoxA mRNA_P_FoxB
mRNA_P_FoxN23 mRNA_P_FoxO mRNA_P_FvMo
mRNA_P_GataC mRNA_P_GataE mRNA_P_Gcad
mRNA_P_Gcm mRNA_P_Gelsolin mRNA_P_HesC
mRNA_P_Hex mRNA_P_Hnf6 mRNA_P_Hox
mRNA_P_Kakapo mRNA_P_L1 mRNA_P_Lim
mRNA_P_Msp130 mRNA_P_MspL mRNA_P_Not
mRNA_P_Nrl mRNA_P_OrCt mRNA_P_Otx
mRNA_P_Pks mRNA_P_Pmar1 mRNA_P_Sm27
mRNA_P_Sm30 mRNA_P_Sm50 mRNA_P_Snail
mRNA_P_SoxB1 mRNA_P_SoxC mRNA_P_SuTx
mRNA_P_TBr mRNA_P_Tel mRNA_P_Tgif
mRNA_P_UbiqAlx1 mRNA_P_UbiqES mRNA_P_UbiqEts1
mRNA_P_UbiqHesC mRNA_P_UbiqHnf6 mRNA_P_UbiqSoxC
mRNA_P_UbiqTel mRNA_P_VEGFR mRNA_P_Wnt8
mRNA_P_cB mRNA_P_z13 ribosome
     
Global parameters
E_Notch_S2 E_Notch_S1 E_Otx_S1 E_Otx_S2
E_SoxB1_S1 E_SoxB1_S2 E_SuH_S2 E_SuH_S1
E_UMR_S2 E_UMR_S1 E_UVAOtx_S2 E_UVAOtx_S1
E_UbiqSoxB1_S1 E_UbiqSoxB1_S2 E_VEGF_S2 E_VEGF_S1
E_cB_S1 E_cB_S2 E_Gcad_S1 E_Gcad_S2
M_UMANrl_S2 M_UMANrl_S1 P_L1_S2 P_L1_S1
M_UMADelta_S2 M_UMADelta_S1 M_UMR_S2 M_UMR_S1
M_SuH_S2 M_SuH_S1 M_Notch_S1 M_Notch_S2
P_UbiqAlx1_S1 P_UbiqAlx1_S2 P_UbiqEts1_S1 P_UbiqEts1_S2
P_UbiqHnf6_S1 P_UbiqHnf6_S2 P_UbiqTel_S1 P_UbiqTel_S2
M_Gcad_S1 M_Gcad_S2 P_Gcad_S1 P_Gcad_S2
P_UbiqES_S1 P_UbiqES_S2 P_UbiqSoxC_S1 P_UbiqSoxC_S2
P_UbiqSoxC_S1 P_UbiqSoxC_S2 P_Otx_S1 P_Otx_S2
M_SoxB1_S1 M_SoxB1_S2 P_cB_S1 P_cB_S2
M_UbiqSoxB1_S1 M_UbiqSoxB1_S2 P_UbiqHesC_S1 P_UbiqHesC_S2
P_Ets1_S1 P_Ets1_S2 M_cB_S1 M_cB_S2
M_Otx_S1 M_Otx_S2    
Reactions (778)
 
 E_Gcad_Hill_Kinetic [PRE_E_Gcad] → [mRNA_E_Gcad];  
 
 E_Notch_Hill_Kinetic [PRE_E_Notch] → [mRNA_E_Notch];  
 
 E_Otx_Hill_Kinetic [PRE_E_Otx] → [mRNA_E_Otx];  
 
 E_SoxB1_Hill_Kinetic [PRE_E_SoxB1] → [mRNA_E_SoxB1];  
 
 E_SuH_Hill_Kinetic [PRE_E_SuH] → [mRNA_E_SuH];  
 
 E_UMR_Hill_Kinetic [PRE_E_UMR] → [mRNA_E_UMR];  
 
 E_UVAOtx_Hill_Kinetic [PRE_E_UVAOtx] → [mRNA_E_UVAOtx];  
 
 E_UbiqSoxB1_Hill_Kinetic [PRE_E_UbiqSoxB1] → [mRNA_E_UbiqSoxB1];  
 
 E_VEGF_Hill_Kinetic [PRE_E_VEGF] → [mRNA_E_VEGF];  
 
 E_cB_Hill_Kinetic [PRE_E_cB] → [mRNA_E_cB];  
 
 GENE_E_Alx1_transcription [GENE_E_Alx1] ↔ [mRNA_E_Alx1];   {PROTEIN_E_Ets1} , {PROTEIN_E_UbiqAlx1} , {PROTEIN_E_Tgif} , {PROTEIN_E_Gcm} , {PROTEIN_E_HesC}
 
 GENE_E_Apobec_transcription [GENE_E_Apobec] → [mRNA_E_Apobec];   {PROTEIN_E_Bra} , {PROTEIN_E_Hox}
 
 GENE_E_Blimp1_transcription [GENE_E_Blimp1] → [mRNA_E_Blimp1];   {PROTEIN_E_Otx} , {PROTEIN_E_Brn} , {PROTEIN_E_GataE} , {PROTEIN_E_nBTCF} , {PROTEIN_E_Eve} , {PROTEIN_E_Blimp1} , {PROTEIN_E_GroTCF}
 
 GENE_E_Bra_transcription [GENE_E_Bra] → [mRNA_E_Bra];   {PROTEIN_E_GataE} , {PROTEIN_E_nBTCF} , {PROTEIN_E_Otx} , {PROTEIN_E_GroTCF}
 
 GENE_E_Brn_transcription [GENE_E_Brn] ↔ [mRNA_E_Brn];   {PROTEIN_E_GataE}
 
 GENE_E_CyP_transcription [GENE_E_CyP] → [mRNA_E_CyP];   {PROTEIN_E_Dri} , {PROTEIN_E_Ets1} , {PROTEIN_E_SoxB1}
 
 GENE_E_Delta_transcription [GENE_E_Delta] → [mRNA_E_Delta];   {PROTEIN_E_UbiqDelta} , {PROTEIN_E_UMADelta} , {PROTEIN_E_Ets1} , {PROTEIN_E_HesC}
 
 GENE_E_Dpt_transcription [GENE_E_Dpt] → [mRNA_E_Dpt];   {PROTEIN_E_Gcm}
 
 GENE_E_Dri_transcription [GENE_E_Dri] → [mRNA_E_Dri];   {PROTEIN_E_Alx1} , {PROTEIN_E_Ets1}
 
 GENE_E_ES_transcription [GENE_E_ES] → [mRNA_E_ES];   {PROTEIN_E_Dri} , {PROTEIN_E_UbiqES} , {PROTEIN_E_HesC}
 
 GENE_E_Endo16_transcription [GENE_E_Endo16] → [mRNA_E_Endo16];   {PROTEIN_E_Otx} , {PROTEIN_E_Brn}
 
 GENE_E_Erg_transcription [GENE_E_Erg] → [mRNA_E_Erg];   {PROTEIN_E_TBr} , {PROTEIN_E_Ets1} , {PROTEIN_E_Hex}
 
 GENE_E_Ets1_transcription [GENE_E_Ets1] → [mRNA_E_Ets1];   {PROTEIN_E_UbiqEts1} , {PROTEIN_E_HesC}
 
 GENE_E_Eve_transcription [GENE_E_Eve] → [mRNA_E_Eve];   {PROTEIN_E_Blimp1} , {PROTEIN_E_nBTCF} , {PROTEIN_E_GroTCF} , {PROTEIN_E_Hox}
 
 GENE_E_Ficolin_transcription [GENE_E_Ficolin] → [mRNA_E_Ficolin];   {PROTEIN_E_Ets1} , {PROTEIN_E_Hnf6} , {PROTEIN_E_Hex} , {PROTEIN_E_Erg}
 
 GENE_E_FoxA_transcription [GENE_E_FoxA] → [mRNA_E_FoxA];   {PROTEIN_E_GataE} , {PROTEIN_E_nBTCF} , {PROTEIN_E_Otx} , {PROTEIN_E_Bra} , {PROTEIN_E_Tgif} , {PROTEIN_E_GroTFC} , {PROTEIN_E_FoxA}
 
 GENE_E_FoxB_transcription [GENE_E_FoxB] → [mRNA_E_FoxB];   {PROTEIN_E_Alx1} , {PROTEIN_E_Ets1} , {PROTEIN_E_TBr} , {PROTEIN_E_Dri} , {PROTEIN_E_FoxB}
 
 GENE_E_FoxN23_transcription [GENE_E_FoxN23] → [mRNA_E_FoxN23];   {PROTEIN_E_nBTCF}
 
 GENE_E_FoxO_transcription [GENE_E_FoxO] → [mRNA_E_FoxO];   {PROTEIN_E_Ets1} , {PROTEIN_E_Hex} , {PROTEIN_E_Tgif} , {PROTEIN_E_Erg}
 
 GENE_E_FvMo_transcription [GENE_E_FvMo] → [mRNA_E_FvMo];   {PROTEIN_E_Gcm} , {PROTEIN_E_GataE}
 
 GENE_E_GataC_transcription [GENE_E_GataC] → [mRNA_E_GataC];   {PROTEIN_E_GataE} , {PROTEIN_E_Hnf6} , {PROTEIN_GCM} , {PROTEIN_E_GataC}
 
 GENE_E_GataE_transcription [GENE_E_GataE] → [mRNA_E_GataE];   {PROTEIN_E_Otx} , {PROTEIN_E_SuHN} , {PROTEIN_E_Hox}
 
 GENE_E_Gcad_transcription [GENE_E_Gcad] → [mRNA_E_Gcad];   {PROTEIN_E_UbiqGcad} , {PROTEIN_E_Snail}
 
 GENE_E_Gcm_transcription [GENE_E_Gcm] → [mRNA_E_Gcm];   {PROTEIN_E_nBTCF} , {PROTEIN_E_SuHN} , {PROTEIN_E_Gcm} , {PROTEIN_E_GroTCF} , {PROTEIN_E_FoxA} , {PROTEIN_E_Alx1}
 
 GENE_E_Gelsolin_transcription [GENE_E_Gelsolin] → [mRNA_E_Gelsolin];   {PROTEIN_E_Bra}
 
 GENE_E_HesC_transcription [GENE_E_HesC] → [mRNA_E_HesC];   {PROTEIN_E_UbiqHesC} , {PROTEIN_E_Pmar1}
 
 GENE_E_Hex_transcription [GENE_E_Hex] → [mRNA_E_Hex];   {PROTEIN_E_Tgif} , {PROTEIN_E_Ets1} , {PROTEIN_E_Erg}
 
 GENE_E_Hnf6_transcription [GENE_E_Hnf6] → [mRNA_E_Hnf6];   {PROTEIN_E_UbiqHnf6}
 
 GENE_E_Hox_transcription [GENE_E_Hox] → [mRNA_E_Hox];   {PROTEIN_E_Blimp1} , {PROTEIN_E_nBTCF} , {PROTEIN_E_Eve} , {PROTEIN_E_Otx} , {PROTEIN_E_GroTCF}
 
 GENE_E_Kakapo_transcription [GENE_E_Kakapo] → [mRNA_E_Kakapo];   {PROTEIN_E_Bra}
 
 GENE_E_Lim_transcription [GENE_E_Lim] → [mRNA_E_Lim];   {PROTEIN_E_GataE} , {PROTEIN_E_Otx}
 
 GENE_E_Msp130_transcription [GENE_E_Msp130] → [mRNA_E_Msp130];   {PROTEIN_E_Hnf6} , {PROTEIN_E_FoxB} , {PROTEIN_E_Ets1} , {PROTEIN_E_Alx1} , {PROTEIN_E_Hex} , {PROTEIN_E_TBr} , {PROTEIN_E_Erg}
 
 GENE_E_MspL_transcription [GENE_E_MspL] → [mRNA_E_MspL];   {PROTEIN_E_Ets1} , {PROTEIN_E_Alx1} , {PROTEIN_E_VEGFSignal} , {PROTEIN_E_Hex} , {PROTEIN_E_Erg}
 
 GENE_E_Not_transcription [GENE_E_Not] → [mRNA_E_Not];   {PROTEIN_E_GataE}
 
 GENE_E_Nrl_transcription [GENE_E_Nrl] → [mRNA_E_Nrl];   {PROTEIN_E_TBr} , {PROTEIN_E_UMANrl} , {PROTEIN_E_FoxN23} , {PROTEIN_E_GataE} , {PROTEIN_E_HesC} , {PROTEIN_E_Tgif}
 
 GENE_E_OrCt_transcription [GENE_E_OrCt] → [mRNA_E_OrCt];   {PROTEIN_E_Bra} , {PROTEIN_E_Hox}
 
 GENE_E_Otx_transcription [GENE_E_Otx] → [mRNA_E_Otx];   {PROTEIN_E_UVAOtx} , {PROTEIN_E_Blimp1} , {PROTEIN_E_GataE} , {PROTEIN_E_Otx}
 
 GENE_E_Pks_transcription [GENE_E_Pks] → [mRNA_E_Pks];   {PROTEIN_E_Gcm} , {PROTEIN_E_GataE}
 
 GENE_E_Pmar1_transcription [GENE_E_Pmar1] → [mRNA_E_Pmar1];   {PROTEIN_E_nBTCF} , {PROTEIN_E_Otx} , {PROTEIN_E_GroTCF}
 
 GENE_E_Sm27_transcription [GENE_E_Sm27] → [mRNA_E_Sm27];   {PROTEIN_E_Dri} , {PROTEIN_E_Hnf6} , {PROTEIN_E_Ets1} , {PROTEIN_E_Alx1} , {PROTEIN_E_Tel} , {PROTEIN_E_Hex} , {PROTEIN_E_Erg}
 
 GENE_E_Sm30_transcription [GENE_E_Sm30] → [mRNA_E_Sm30];   {PROTEIN_E_VEGFSignal}
 
 GENE_E_Sm50_transcription [GENE_E_Sm50] → [mRNA_E_Sm50];   {PROTEIN_E_Dri} , {PROTEIN_E_Hnf6} , {PROTEIN_E_Ets1} , {PROTEIN_E_Alx1} , {PROTEIN_E_Tel} , {PROTEIN_E_Hex} , {PROTEIN_E_Erg} , {PROTEIN_E_VEGFSignal}
 
 GENE_E_Snail_transcription [GENE_E_Snail] → [mRNA_E_Snail];   {PROTEIN_E_Hex}
 
 GENE_E_SoxB1_transcription [GENE_E_SoxB1] → [mRNA_E_SoxB1];   {PROTEIN_E_UbiqSoxB1} , {PROTEIN_E_SoxB1}
 
 GENE_E_SoxC_transcription [GENE_E_SoxC] → [mRNA_E_SoxC];   {PROTEIN_E_UbiqSoxC} , {PROTEIN_E_HesC} , {PROTEIN_E_SoxC}
 
 GENE_E_SuTx_transcription [GENE_E_SuTx] → [mRNA_E_SuTx];   {PROTEIN_E_Gcm} , {PROTEIN_E_GataE}
 
 GENE_E_TBr_transcription [GENE_E_TBr] → [mRNA_E_TBr];   {PROTEIN_E_Ets1} , {PROTEIN_E_HesC} , {PROTEIN_E_TBr}
 
 GENE_E_Tel_transcription [GENE_E_Tel] → [mRNA_E_Tel];   {PROTEIN_E_UbiqTel} , {PROTEIN_E_Tel} , {PROTEIN_E_HesC}
 
 GENE_E_Tgif_transcription [GENE_E_Tgif] → [mRNA_E_Tgif];   {PROTEIN_E_Tgif} , {PROTEIN_E_Ets1} , {PROTEIN_E_Erg} , {PROTEIN_E_Hex}
 
 GENE_E_VEGFR_transcription [GENE_E_VEGFR] → [mRNA_E_VEGFR];   {PROTEIN_E_Alx1} , {PROTEIN_E_Dri} , {PROTEIN_E_Ets1} , {PROTEIN_E_Hex}
 
 GENE_E_Wnt8_transcription [GENE_E_Wnt8] → [mRNA_E_Wnt8];   {PROTEIN_E_nBTCF} , {PROTEIN_E_Blimp1} , {PROTEIN_E_GroTCF}
 
 GENE_E_z13_transcription [GENE_E_z13] → [mRNA_E_z13];   {PROTEIN_E_nBTCF} , {PROTEIN_E_GroTCF} , {PROTEIN_E_Hnf6}
 
 GENE_M_Alx1_transcription [GENE_M_Alx1] → [mRNA_M_Alx1];   {PROTEIN_M_Ets1} , {PROTEIN_M_UbiqAlx1} , {PROTEIN_M_Tgif} , {PROTEIN_M_Gcm} , {PROTEIN_M_HesC}
 
 GENE_M_Apobec_transcription [GENE_M_Apobec] → [mRNA_M_Apobec];   {PROTEIN_M_Bra} , {PROTEIN_E_Bra} , {PROTEIN_M_Hox}
 
 GENE_M_Blimp1_transcription [GENE_M_Blimp1] → [mRNA_M_Blimp1];   {PROTEIN_M_Otx} , {PROTEIN_M_Brn} , {PROTEIN_M_GataE} , {PROTEIN_M_nBTCF} , {PROTEIN_M_Eve} , {PROTEIN_M_Blimp1} , {PROTEIN_M_GroTCF}
 
 GENE_M_Bra_transcription [GENE_M_Bra] → [mRNA_M_Bra];   {PROTEIN_M_GataE} , {PROTEIN_M_nBTCF} , {PROTEIN_M_Otx} , {PROTEIN_M_GroTCF}
 
 GENE_M_Brn_transcription [GENE_M_Brn] → [mRNA_M_Brn];   {PROTEIN_M_GataE}
 
 GENE_M_CAPK_transcription [GENE_M_CAPK] → [mRNA_M_CAPK];   {PROTEIN_E_Bra}
 
 GENE_M_CyP_transcription [GENE_M_CyP] → [mRNA_M_CyP];   {PROTEIN_M_Dri} , {PROTEIN_M_Ets1} , {PROTEIN_M_SoxB1}
 
 GENE_M_Delta_transcription [GENE_M_Delta] → [mRNA_M_Delta];   {PROTEIN_M_UbiqDelta} , {PROTEIN_M_UMADelta} , {PROTEIN_M_Ets1} , {PROTEIN_M_HesC}
 
 GENE_M_Dpt_transcription [GENE_M_Dpt] → [mRNA_M_Dpt];   {PROTEIN_E_Bra} , {PROTEIN_M_Gcm}
 
 GENE_M_Dri_transcription [GENE_M_Dri] → [mRNA_M_Dri];   {PROTEIN_M_Alx1} , {PROTEIN_M_Ets1}
 
 GENE_M_Endo16_transcription [GENE_M_Endo16] → [mRNA_M_Endo16];   {PROTEIN_M_Otx} , {PROTEIN_M_Brn}
 
 GENE_M_Erg_transcription [GENE_M_Erg] → [mRNA_M_Erg];   {PROTEIN_M_TBr} , {PROTEIN_M_Ets1} , {PROTEIN_M_Hex}
 
 GENE_M_Ets1_transcription [GENE_M_Ets1] → [mRNA_M_Ets1];   {PROTEIN_M_UbiqEts1} , {PROTEIN_M_HesC}
 
 GENE_M_Eve_transcription [GENE_M_Eve] → [mRNA_M_Eve];   {PROTEIN_M_Blimp1} , {PROTEIN_M_nBTCF} , {PROTEIN_M_GroTCF} , {PROTEIN_M_Hox}
 
 GENE_M_Ficolin_transcription [GENE_M_Ficolin] → [mRNA_M_Ficolin];   {PROTEIN_M_Ets1} , {PROTEIN_M_Hnf6} , {PROTEIN_M_Hex} , {PROTEIN_M_Erg}
 
 GENE_M_FoxA_transcription [GENE_M_FoxA] → [mRNA_M_FoxA];   {PROTEIN_M_GataE} , {PROTEIN_M_nBTCF} , {PROTEIN_M_Otx} , {PROTEIN_M_Bra} , {PROTEIN_M_Tgif} , {PROTEIN_M_GroTFC} , {PROTEIN_M_FoxA}
 
 GENE_M_FoxB_transcription [GENE_M_FoxB] → [mRNA_M_FoxB];   {PROTEIN_M_Alx1} , {PROTEIN_M_Ets1} , {PROTEIN_M_TBr} , {PROTEIN_M_Dri} , {PROTEIN_M_FoxB}
 
 GENE_M_FoxN23_transcription [GENE_M_FoxN23] → [mRNA_M_FoxN23];   {PROTEIN_M_nBTCF}
 
 GENE_M_FoxO_transcription [GENE_M_FoxO] → [mRNA_M_FoxO];   {PROTEIN_M_Ets1} , {PROTEIN_M_Hex} , {PROTEIN_M_Tgif} , {PROTEIN_M_Erg}
 
 GENE_M_FvMo_transcription [GENE_M_FvMo] → [mRNA_M_FvMo];   {PROTEIN_M_Gcm} , {PROTEIN_M_GataE}
 
 GENE_M_GataC_transcription [GENE_M_GataC] → [mRNA_M_GataC];   {PROTEIN_M_GataE} , {PROTEIN_M_Hnf6} , {PROTEIN_GCM} , {PROTEIN_M_GataC}
 
 GENE_M_GataE_transcription [GENE_M_GataE] → [mRNA_M_GataE];   {PROTEIN_M_Otx} , {PROTEIN_M_SuHN} , {PROTEIN_M_Hox}
 
 GENE_M_Gcad_transcription [GENE_M_Gcad] → [mRNA_M_Gcad];   {PROTEIN_M_UbiqGcad} , {PROTEIN_M_Snail}
 
 GENE_M_Gcm_transcription [GENE_M_Gcm] → [mRNA_M_Gcm];   {PROTEIN_M_nBTCF} , {PROTEIN_M_SuHN} , {PROTEIN_M_Gcm} , {PROTEIN_M_GroTCF} , {PROTEIN_M_FoxA} , {PROTEIN_M_Alx1}
 
 GENE_M_Gelsolin_transcription [GENE_M_Gelsolin] → [mRNA_M_Gelsolin];   {PROTEIN_M_Bra} , {PROTEIN_E_Bra}
 
 GENE_M_HesC_transcription [GENE_M_HesC] → [mRNA_M_HesC];   {PROTEIN_M_UbiqHesC} , {PROTEIN_M_Pmar1}
 
 GENE_M_Hex_transcription [GENE_M_Hex] → [mRNA_M_Hex];   {PROTEIN_M_Tgif} , {PROTEIN_M_Ets1} , {PROTEIN_M_Erg}
 
 GENE_M_Hnf6_transcription [GENE_M_Hnf6] → [mRNA_M_Hnf6];   {PROTEIN_M_UbiqHnf6}
 
 GENE_M_Hox_transcription [GENE_M_Hox] → [mRNA_M_Hox];   {PROTEIN_M_Blimp1} , {PROTEIN_M_nBTCF} , {PROTEIN_M_Eve} , {PROTEIN_M_Otx} , {PROTEIN_M_GroTCF}
 
 GENE_M_Kakapo_transcription [GENE_M_Kakapo] → [mRNA_M_Kakapo];   {PROTEIN_M_Bra} , {PROTEIN_E_Bra}
 
 GENE_M_Lim_transcription [GENE_M_Lim] → [mRNA_M_Lim];   {PROTEIN_M_GataE} , {PROTEIN_M_Otx}
 
 GENE_M_Msp130_transcription [GENE_M_Msp130] → [mRNA_M_Msp130];   {PROTEIN_M_Hnf6} , {PROTEIN_M_FoxB} , {PROTEIN_M_Ets1} , {PROTEIN_M_Alx1} , {PROTEIN_M_Hex} , {PROTEIN_M_TBr} , {PROTEIN_M_Erg}
 
 GENE_M_MspL_transcription [GENE_M_MspL] → [mRNA_M_MspL];   {PROTEIN_M_Ets1} , {PROTEIN_M_Alx1} , {PROTEIN_M_VEGFSignal} , {PROTEIN_M_Hex} , {PROTEIN_M_Erg}
 
 GENE_M_Not_transcription [GENE_M_Not] → [mRNA_M_Not];   {PROTEIN_M_GataE}
 
 GENE_M_Nrl_transcription [GENE_M_Nrl] → [mRNA_M_Nrl];   {PROTEIN_M_TBr} , {PROTEIN_M_UMANrl} , {PROTEIN_M_FoxN23} , {PROTEIN_M_GataE} , {PROTEIN_M_HesC} , {PROTEIN_E_Bra} , {PROTEIN_M_Tgif}
 
 GENE_M_OrCt_transcription [GENE_M_OrCt] → [mRNA_M_OrCt];   {PROTEIN_M_Bra} , {PROTEIN_E_Bra} , {PROTEIN_M_Hox}
 
 GENE_M_Otx_transcription [GENE_M_Otx] → [mRNA_M_Otx];   {PROTEIN_M_UVAOtx} , {PROTEIN_M_Blimp1} , {PROTEIN_M_GataE} , {PROTEIN_M_Otx}
 
 GENE_M_Pks_transcription [GENE_M_Pks] → [mRNA_M_Pks];   {PROTEIN_E_Bra} , {PROTEIN_M_Gcm} , {PROTEIN_M_GataE}
 
 GENE_M_Pmar1_transcription [GENE_M_Pmar1] → [mRNA_M_Pmar1];   {PROTEIN_M_nBTCF} , {PROTEIN_M_Otx} , {PROTEIN_M_GroTCF}
 
 GENE_M_Sm27_transcription [GENE_M_Sm27] → [mRNA_M_Sm27];   {PROTEIN_M_Dri} , {PROTEIN_M_Hnf6} , {PROTEIN_M_Ets1} , {PROTEIN_M_Alx1} , {PROTEIN_M_Tel} , {PROTEIN_M_Hex} , {PROTEIN_M_Erg}
 
 GENE_M_Sm30_transcription [GENE_M_Sm30] → [mRNA_M_Sm30];   {PROTEIN_M_VEGFSignal}
 
 GENE_M_Sm50_transcription [GENE_M_Sm50] → [mRNA_M_Sm50];   {PROTEIN_M_Dri} , {PROTEIN_M_Hnf6} , {PROTEIN_M_Ets1} , {PROTEIN_M_Alx1} , {PROTEIN_M_Tel} , {PROTEIN_M_Hex} , {PROTEIN_M_Erg} , {PROTEIN_M_VEGFSignal}
 
 GENE_M_Snail_transcription [GENE_M_Snail] → [mRNA_M_Snail];   {PROTEIN_M_Hex}
 
 GENE_M_SoxB1_transcription [GENE_M_SoxB1] → [mRNA_M_SoxB1];   {PROTEIN_M_UbiqSoxB1} , {PROTEIN_M_SoxB1}
 
 GENE_M_SoxC_transcription [GENE_M_SoxC] → [mRNA_M_SoxC];   {PROTEIN_M_UbiqSoxC} , {PROTEIN_M_HesC} , {PROTEIN_M_SoxC}
 
 GENE_M_SuTx_transcription [GENE_M_SuTx] → [mRNA_M_SuTx];   {PROTEIN_M_Gcm} , {PROTEIN_M_GataE}
 
 GENE_M_TBr_transcription [GENE_M_TBr] → [mRNA_M_TBr];   {PROTEIN_M_Ets1} , {PROTEIN_M_HesC} , {PROTEIN_M_TBr}
 
 GENE_M_Tel_transcription [GENE_M_Tel] → [mRNA_M_Tel];   {PROTEIN_M_UbiqTel} , {PROTEIN_M_Tel} , {PROTEIN_M_HesC}
 
 GENE_M_Tgif_transcription [GENE_M_Tgif] → [mRNA_M_Tgif];   {PROTEIN_M_Tgif} , {PROTEIN_M_Ets1} , {PROTEIN_M_Erg} , {PROTEIN_M_Hex}
 
 GENE_M_VEGFR_transcription [GENE_M_VEGFR] → [mRNA_M_VEGFR];   {PROTEIN_M_Alx1} , {PROTEIN_M_Dri} , {PROTEIN_M_Ets1} , {PROTEIN_M_Hex}
 
 GENE_M_Wnt8_transcription [GENE_M_Wnt8] → [mRNA_M_Wnt8];   {PROTEIN_M_nBTCF} , {PROTEIN_M_Blimp1} , {PROTEIN_M_GroTCF}
 
 GENE_M_z13_transcription [GENE_M_z13] → [mRNA_M_z13];   {PROTEIN_M_nBTCF} , {PROTEIN_M_GroTCF} , {PROTEIN_M_Hnf6}
 
 GENE_P_Alx1_transcription [GENE_P_Alx1] → [mRNA_P_Alx1];   {PROTEIN_P_Ets1} , {PROTEIN_P_UbiqAlx1} , {PROTEIN_P_Tgif} , {PROTEIN_P_Gcm} , {PROTEIN_P_HesC}
 
 GENE_P_Apobec_transcription [GENE_P_Apobec] → [mRNA_P_Apobec];   {PROTEIN_P_Bra} , {PROTEIN_P_Hox}
 
 GENE_P_Blimp1_transcription [GENE_P_Blimp1] → [mRNA_P_Blimp1];   {PROTEIN_P_Otx} , {PROTEIN_P_Brn} , {PROTEIN_P_GataE} , {PROTEIN_P_nBTCF} , {PROTEIN_P_Eve} , {PROTEIN_P_Blimp1} , {PROTEIN_P_GroTCF}
 
 GENE_P_Bra_transcription [GENE_P_Bra] → [mRNA_P_Bra];   {PROTEIN_P_GataE} , {PROTEIN_P_nBTCF} , {PROTEIN_P_Otx} , {PROTEIN_P_GroTCF}
 
 GENE_P_Brn_transcription [GENE_P_Brn] → [mRNA_P_Brn];   {PROTEIN_P_GataE}
 
 GENE_P_CyP_transcription [GENE_P_CyP] → [mRNA_P_CyP];   {PROTEIN_P_Dri} , {PROTEIN_P_Ets1} , {PROTEIN_P_SoxB1}
 
 GENE_P_Delta_transcription [GENE_P_Delta] → [mRNA_P_Delta];   {PROTEIN_P_UbiqDelta} , {PROTEIN_P_UMADelta} , {PROTEIN_P_Ets1} , {PROTEIN_P_HesC}
 
 GENE_P_Dpt_transcription [GENE_P_Dpt] → [mRNA_P_Dpt];   {PROTEIN_P_Gcm}
 
 GENE_P_Dri_transcription [GENE_P_Dri] → [mRNA_P_Dri];   {PROTEIN_P_Alx1} , {PROTEIN_P_Ets1}
 
 GENE_P_Endo16_transcription [GENE_P_Endo16] → [mRNA_P_Endo16];   {PROTEIN_P_Otx} , {PROTEIN_P_Brn}
 
 GENE_P_Erg_transcription [GENE_P_Erg] → [mRNA_P_Erg];   {PROTEIN_P_TBr} , {PROTEIN_P_Ets1} , {PROTEIN_P_Hex}
 
 GENE_P_Ets1_transcription [GENE_P_Ets1] → [mRNA_P_Ets1];   {PROTEIN_P_UbiqEts1} , {PROTEIN_P_HesC}
 
 GENE_P_Eve_transcription [GENE_P_Eve] → [mRNA_P_Eve];   {PROTEIN_P_Blimp1} , {PROTEIN_P_nBTCF} , {PROTEIN_P_GroTCF} , {PROTEIN_P_Hox}
 
 GENE_P_Ficolin_transcription [GENE_P_Ficolin] → [mRNA_P_Ficolin];   {PROTEIN_P_Ets1} , {PROTEIN_P_Hnf6} , {PROTEIN_P_Hex} , {PROTEIN_P_Erg}
 
 GENE_P_FoxA_transcription [GENE_P_FoxA] → [mRNA_P_FoxA];   {PROTEIN_P_GataE} , {PROTEIN_P_nBTCF} , {PROTEIN_P_Otx} , {PROTEIN_P_Bra} , {PROTEIN_P_Tgif} , {PROTEIN_P_GroTFC} , {PROTEIN_P_FoxA}
 
 GENE_P_FoxB_transcription [GENE_P_FoxB] → [mRNA_P_FoxB];   {PROTEIN_P_Alx1} , {PROTEIN_P_Ets1} , {PROTEIN_P_TBr} , {PROTEIN_P_Dri} , {PROTEIN_P_FoxB}
 
 GENE_P_FoxN23_transcription [GENE_P_FoxN23] → [mRNA_P_FoxN23];   {PROTEIN_P_nBTCF}
 
 GENE_P_FoxO_transcription [GENE_P_FoxO] → [mRNA_P_FoxO];   {PROTEIN_P_Ets1} , {PROTEIN_P_Hex} , {PROTEIN_P_Tgif} , {PROTEIN_P_Erg}
 
 GENE_P_FvMo_transcription [GENE_P_FvMo] → [mRNA_P_FvMo];   {PROTEIN_P_Gcm} , {PROTEIN_P_GataE}
 
 GENE_P_GataC_transcription [GENE_P_GataC] → [mRNA_P_GataC];   {PROTEIN_P_GataE} , {PROTEIN_P_Hnf6} , {PROTEIN_GCM} , {PROTEIN_P_GataC}
 
 GENE_P_GataE_transcription [GENE_P_GataE] → [mRNA_P_GataE];   {PROTEIN_P_Otx} , {PROTEIN_P_SuHN} , {PROTEIN_P_Hox}
 
 GENE_P_Gcad_transcription [GENE_P_Gcad] → [mRNA_P_Gcad];   {PROTEIN_P_UbiqGcad} , {PROTEIN_P_Snail}
 
 GENE_P_Gcm_transcription [GENE_P_Gcm] → [mRNA_P_Gcm];   {PROTEIN_P_nBTCF} , {PROTEIN_P_SuHN} , {PROTEIN_P_Gcm} , {PROTEIN_P_GroTCF} , {PROTEIN_P_FoxA} , {PROTEIN_P_Alx1}
 
 GENE_P_Gelsolin_transcription [GENE_P_Gelsolin] → [mRNA_P_Gelsolin];   {PROTEIN_P_Bra}
 
 GENE_P_HesC_transcription [GENE_P_HesC] → [mRNA_P_HesC];   {PROTEIN_P_UbiqHesC} , {PROTEIN_P_Pmar1}
 
 GENE_P_Hex_transcription [GENE_P_Hex] → [mRNA_P_Hex];   {PROTEIN_P_Tgif} , {PROTEIN_P_Ets1} , {PROTEIN_P_Erg}
 
 GENE_P_Hnf6_transcription [GENE_P_Hnf6] → [mRNA_P_Hnf6];   {PROTEIN_P_UbiqHnf6}
 
 GENE_P_Hox_transcription [GENE_P_Hox] → [mRNA_P_Hox];   {PROTEIN_P_Blimp1} , {PROTEIN_P_nBTCF} , {PROTEIN_P_Eve} , {PROTEIN_P_Otx} , {PROTEIN_P_GroTCF}
 
 GENE_P_Kakapo_transcription [GENE_P_Kakapo] → [mRNA_P_Kakapo];   {PROTEIN_P_Bra}
 
 GENE_P_Lim_transcription [GENE_P_Lim] → [mRNA_P_Lim];   {PROTEIN_P_GataE} , {PROTEIN_P_Otx}
 
 GENE_P_Msp130_transcription [GENE_P_Msp130] → [mRNA_P_Msp130];   {PROTEIN_P_Hnf6} , {PROTEIN_P_FoxB} , {PROTEIN_P_Ets1} , {PROTEIN_P_Alx1} , {PROTEIN_P_Hex} , {PROTEIN_P_TBr} , {PROTEIN_P_Erg}
 
 GENE_P_MspL_transcription [GENE_P_MspL] → [mRNA_P_MspL];   {PROTEIN_P_Ets1} , {PROTEIN_P_Alx1} , {PROTEIN_P_VEGFSignal} , {PROTEIN_P_Hex} , {PROTEIN_P_Erg}
 
 GENE_P_Not_transcription [GENE_P_Not] → [mRNA_P_Not];   {PROTEIN_P_GataE}
 
 GENE_P_Nrl_transcription [GENE_P_Nrl] → [mRNA_P_Nrl];   {PROTEIN_P_TBr} , {PROTEIN_P_UMANrl} , {PROTEIN_P_FoxN23} , {PROTEIN_P_GataE} , {PROTEIN_P_HesC} , {PROTEIN_P_Tgif}
 
 GENE_P_OrCt_transcription [GENE_P_OrCt] → [mRNA_P_OrCt];   {PROTEIN_P_Bra} , {PROTEIN_P_Hox}
 
 GENE_P_Otx_transcription [GENE_P_Otx] → [mRNA_P_Otx];   {PROTEIN_P_UVAOtx} , {PROTEIN_P_Blimp1} , {PROTEIN_P_GataE} , {PROTEIN_P_Otx}
 
 GENE_P_Pks_transcription [GENE_P_Pks] → [mRNA_P_Pks];   {PROTEIN_P_Gcm} , {PROTEIN_P_GataE}
 
 GENE_P_Pmar1_transcription [GENE_P_Pmar1] → [mRNA_P_Pmar1];   {PROTEIN_P_nBTCF} , {PROTEIN_P_Otx} , {PROTEIN_P_GroTCF}
 
 GENE_P_Sm27_transcription [GENE_P_Sm27] → [mRNA_P_Sm27];   {PROTEIN_P_Dri} , {PROTEIN_P_Hnf6} , {PROTEIN_P_Ets1} , {PROTEIN_P_Alx1} , {PROTEIN_P_Tel} , {PROTEIN_P_Hex} , {PROTEIN_P_Erg}
 
 GENE_P_Sm30_transcription [GENE_P_Sm30] → [mRNA_P_Sm30];   {PROTEIN_P_VEGFSignal}
 
 GENE_P_Sm50_transcription [GENE_P_Sm50] → [mRNA_P_Sm50];   {PROTEIN_P_Dri} , {PROTEIN_P_Hnf6} , {PROTEIN_P_Ets1} , {PROTEIN_P_Alx1} , {PROTEIN_P_Tel} , {PROTEIN_P_Hex} , {PROTEIN_P_Erg} , {PROTEIN_P_VEGFSignal}
 
 GENE_P_Snail_transcription [GENE_P_Snail] → [mRNA_P_Snail];   {PROTEIN_P_Hex}
 
 GENE_P_SoxB1_transcription [GENE_P_SoxB1] → [mRNA_P_SoxB1];   {PROTEIN_P_UbiqSoxB1} , {PROTEIN_P_SoxB1}
 
 GENE_P_SoxC_transcription [GENE_P_SoxC] → [mRNA_P_SoxC];   {PROTEIN_P_UbiqSoxC} , {PROTEIN_P_HesC} , {PROTEIN_P_SoxC}
 
 GENE_P_SuTx_transcription [GENE_P_SuTx] → [mRNA_P_SuTx];   {PROTEIN_P_Gcm} , {PROTEIN_P_GataE}
 
 GENE_P_TBr_transcription [GENE_P_TBr] → [mRNA_P_TBr];   {PROTEIN_P_Ets1} , {PROTEIN_P_HesC} , {PROTEIN_P_TBr}
 
 GENE_P_Tel_transcription [GENE_P_Tel] → [mRNA_P_Tel];   {PROTEIN_P_UbiqTel} , {PROTEIN_P_Tel} , {PROTEIN_P_HesC}
 
 GENE_P_Tgif_transcription [GENE_P_Tgif] → [mRNA_P_Tgif];   {PROTEIN_P_Tgif} , {PROTEIN_P_Ets1} , {PROTEIN_P_Erg} , {PROTEIN_P_Hex}
 
 GENE_P_VEGFR_transcription [GENE_P_VEGFR] → [mRNA_P_VEGFR];   {PROTEIN_P_Alx1} , {PROTEIN_P_Dri} , {PROTEIN_P_Ets1} , {PROTEIN_P_Hex}
 
 GENE_P_Wnt8_transcription [GENE_P_Wnt8] → [mRNA_P_Wnt8];   {PROTEIN_P_nBTCF} , {PROTEIN_P_Blimp1} , {PROTEIN_P_GroTCF}
 
 GENE_P_z13_transcription [GENE_P_z13] → [mRNA_P_z13];   {PROTEIN_P_nBTCF} , {PROTEIN_P_GroTCF} , {PROTEIN_P_Hnf6}
 
 M_Gcad_Hill_Kinetic [PRE_M_Gcad] → [mRNA_M_Gcad];  
 
 M_Notch_Hill_Kinetic [PRE_M_Notch] → [mRNA_M_Notch];  
 
 M_Otx_Hill_Kinetic [PRE_M_Otx] → [mRNA_M_Otx];  
 
 M_SoxB1_Hill_Kinetic [PRE_M_SoxB1] → [mRNA_M_SoxB1];  
 
 M_SuH_Hill_Kinetic [PRE_M_SuH] → [mRNA_M_SuH];  
 
 M_UMADelta_Hill_Kinetic [PRE_M_UMADelta] → [mRNA_M_UMADelta];  
 
 M_UMANrl_Hill_Kinetic [PRE_M_UMANrl] → [mRNA_M_UMANrl];  
 
 M_UMR_Hill_Kinetic [PRE_M_UMR] → [mRNA_M_UMR];  
 
 M_UbiqSoxB1_Hill_Kinetic [PRE_M_UbiqSoxB1] → [mRNA_M_UbiqSoxB1];  
 
 M_cB_Hill_Kinetic [PRE_M_cB] → [mRNA_M_cB];  
 
 PROTEIN_E_Alx1_degradation [PROTEIN_E_Alx1] → [none];   {none}
 
 PROTEIN_E_Apobec_degradation [PROTEIN_E_Apobec] → [none];   {none}
 
 PROTEIN_E_Blimp1_degradation [PROTEIN_E_Blimp1] → [none];   {none}
 
 PROTEIN_E_Bra_degradation [PROTEIN_E_Bra] → [none];   {none}
 
 PROTEIN_E_Brn_degradation [PROTEIN_E_Brn] → [none];   {none}
 
 PROTEIN_E_CAPK_degradation [PROTEIN_E_CAPK] → [none];   {none}
 
 PROTEIN_E_CyP_degradation [PROTEIN_E_CyP] → [none];   {none}
 
 PROTEIN_E_Delta_activation [PROTEIN_E_Delta2] → [PROTEIN_E_Delta];   {PROTEIN_E_Nrl}
 
 PROTEIN_E_Delta_degradation [PROTEIN_E_Delta] → [none];   {none}
 
 PROTEIN_E_Delta_inactivation [PROTEIN_E_Delta] → [PROTEIN_E_Delta2];  
 
 PROTEIN_E_Dpt_degradation [PROTEIN_E_Dpt] → [none];   {none}
 
 PROTEIN_E_Dri_degradation [PROTEIN_E_Dri] → [none];   {none}
 
 PROTEIN_E_ES_degradation [PROTEIN_E_ES] → [none];   {none}
 
 PROTEIN_E_Endo16_degradation [PROTEIN_E_Endo16] → [none];   {none}
 
 PROTEIN_E_Erg_degradation [PROTEIN_E_Erg] → [none];   {none}
 
 PROTEIN_E_Ets1_degradation [PROTEIN_E_Ets1] → [none];   {none}
 
 PROTEIN_E_Eve_degradation [PROTEIN_E_Eve] → [none];   {none}
 
 PROTEIN_E_Ficolin_degradation [PROTEIN_E_Ficolin] → [none];   {none}
 
 PROTEIN_E_FoxA_degradation [PROTEIN_E_FoxA] → [none];   {none}
 
 PROTEIN_E_FoxB_degradation [PROTEIN_E_FoxB] → [none];   {none}
 
 PROTEIN_E_FoxN23_degradation [PROTEIN_E_FoxN23] → [none];   {none}
 
 PROTEIN_E_FoxO_degradation [PROTEIN_E_FoxO] → [none];   {none}
 
 PROTEIN_E_FvMo_degradation [PROTEIN_E_FvMo] → [none];   {none}
 
 PROTEIN_E_GSK3_i_activation [PROTEIN_E_GSK3_a] → [PROTEIN_E_GSK3_i];   {PROTEIN_E_frizzled_a}
 
 PROTEIN_E_GSK3_i_inactivation [PROTEIN_E_GSK3_i] → [PROTEIN_E_GSK3_a];  
 
 PROTEIN_E_GataC_degradation [PROTEIN_E_GataC] → [none];   {none}
 
 PROTEIN_E_GataE_degradation [PROTEIN_E_GataE] → [none];   {none}
 
 PROTEIN_E_Gcad_degradation [PROTEIN_E_Gcad] → [none];   {none}
 
 PROTEIN_E_Gcm_degradation [PROTEIN_E_Gcm] → [none];   {none}
 
 PROTEIN_E_Gelsolin_degradation [PROTEIN_E_Gelsolin] → [none];   {none}
 
 PROTEIN_E_GroTCF_accociation [PROTEIN_E_Gro] + [PROTEIN_E_TCF] → [PROTEIN_E_GroTCF];  
 
 PROTEIN_E_GroTCF_dissociation [PROTEIN_E_GroTCF] → [PROTEIN_E_Gro] + [PROTEIN_E_TCF];  
 
 PROTEIN_E_HesC_degradation [PROTEIN_E_HesC] → [none];   {none}
 
 PROTEIN_E_Hex_degradation [PROTEIN_E_Hex] → [none];   {none}
 
 PROTEIN_E_Hnf6_degradation [PROTEIN_E_Hnf6] → [none];   {none}
 
 PROTEIN_E_Hox_degradation [PROTEIN_E_Hox] → [none];   {none}
 
 PROTEIN_E_Kakapo_degradation [PROTEIN_E_Kakapo] → [none];   {none}
 
 PROTEIN_E_Lim_degradation [PROTEIN_E_Lim] → [none];   {none}
 
 PROTEIN_E_Msp130_degradation [PROTEIN_E_Msp130] → [none];   {none}
 
 PROTEIN_E_MspL_degradation [PROTEIN_E_MspL] → [none];   {none}
 
 PROTEIN_E_Not_degradation [PROTEIN_E_Not] → [none];   {none}
 
 PROTEIN_E_Notch_activation [PROTEIN_E_Notch2] → [PROTEIN_E_Notch];   {PROTEIN_E_Delta2}
 
 PROTEIN_E_Notch_degradation [PROTEIN_E_Notch] → [none];   {none}
 
 PROTEIN_E_Notch_inactivation [PROTEIN_E_Notch] → [PROTEIN_E_Notch2];  
 
 PROTEIN_E_Nrl_degradation [PROTEIN_E_Nrl] → [none];   {none}
 
 PROTEIN_E_OrCt_degradation [PROTEIN_E_OrCt] → [none];   {none}
 
 PROTEIN_E_Otx_degradation [PROTEIN_E_Otx] → [none];   {none}
 
 PROTEIN_E_Pks_degradation [PROTEIN_E_Pks] → [none];   {none}
 
 PROTEIN_E_Pmar1_degradation [PROTEIN_E_Pmar1] → [none];   {none}
 
 PROTEIN_E_Sm27_degradation [PROTEIN_E_Sm27] → [none];   {none}
 
 PROTEIN_E_Sm30_degradation [PROTEIN_E_Sm30] → [none];   {none}
 
 PROTEIN_E_Sm50_degradation [PROTEIN_E_Sm50] → [none];   {none}
 
 PROTEIN_E_Snail_degradation [PROTEIN_E_Snail] → [none];   {none}
 
 PROTEIN_E_SoxB1_degradation [PROTEIN_E_SoxB1] → [none];   {none}
 
 PROTEIN_E_SoxC_degradation [PROTEIN_E_SoxC] → [none];   {none}
 
 PROTEIN_E_SuHN_accociation [PROTEIN_E_Notch2] + [PROTEIN_E_SuH] → [PROTEIN_E_SuHN];  
 
 PROTEIN_E_SuHN_dissociation [PROTEIN_E_SuHN] → [PROTEIN_E_Notch2] + [PROTEIN_E_SuH];  
 
 PROTEIN_E_SuH_degradation [PROTEIN_E_SuH] → [none];   {none}
 
 PROTEIN_E_SuTx_degradation [PROTEIN_E_SuTx] → [none];   {none}
 
 PROTEIN_E_TBr_degradation [PROTEIN_E_TBr] → [none];   {none}
 
 PROTEIN_E_Tel_degradation [PROTEIN_E_Tel] → [none];   {none}
 
 PROTEIN_E_Tgif_degradation [PROTEIN_E_Tgif] → [none];   {none}
 
 PROTEIN_E_UMR_degradation [PROTEIN_E_UMR] → [none];   {none}
 
 PROTEIN_E_UVAOtx_degradation [PROTEIN_E_UVAOtx] → [none];   {none}
 
 PROTEIN_E_UbiqSoxB1_degradation [PROTEIN_E_UbiqSoxB1] → [none];   {none}
 
 PROTEIN_E_VEGFR_degradation [PROTEIN_E_VEGFR] → [none];   {none}
 
 PROTEIN_E_VEGFSignal_accociation [PROTEIN_E_L1] + [PROTEIN_E_VEGFR] + [PROTEIN_E_VEGF] → [PROTEIN_E_VEGFSignal];  
 
 PROTEIN_E_VEGFSignal_dissociation [PROTEIN_E_VEGFSignal] → [PROTEIN_E_L1] + [PROTEIN_E_VEGFR] + [PROTEIN_E_VEGF];  
 
 PROTEIN_E_VEGF_degradation [PROTEIN_E_VEGF] → [none];   {none}
 
 PROTEIN_E_Wnt8_degradation [PROTEIN_E_Wnt8] → [none];   {none}
 
 PROTEIN_E_cB_a_degradation [PROTEIN_E_cB] → ;   {PROTEIN_E_GSK3_a}
 
 PROTEIN_E_cB_degradation [PROTEIN_E_cB] → [none];   {none}
 
 PROTEIN_E_frizzled_a_activation [PROTEIN_E_frizzled_i] → [PROTEIN_E_frizzled_a];   {PROTEIN_E_Wnt8}
 
 PROTEIN_E_frizzled_a_inactivation [PROTEIN_E_frizzled_a] → [PROTEIN_E_frizzled_i];  
 
 PROTEIN_E_nBTCF_accociation [PROTEIN_E_cB] + [PROTEIN_E_TCF] → [PROTEIN_E_nBTCF];  
 
 PROTEIN_E_nBTCF_dissociation [PROTEIN_E_nBTCF] → [PROTEIN_E_cB] + [PROTEIN_E_TCF];  
 
 PROTEIN_E_z13_degradation [PROTEIN_E_z13] → [none];   {none}
 
 PROTEIN_M_Alx1_degradation [PROTEIN_M_Alx1] → [none];   {none}
 
 PROTEIN_M_Apobec_degradation [PROTEIN_M_Apobec] → [none];   {none}
 
 PROTEIN_M_Blimp1_degradation [PROTEIN_M_Blimp1] → [none];   {none}
 
 PROTEIN_M_Bra_degradation [PROTEIN_M_Bra] → [none];   {none}
 
 PROTEIN_M_Brn_degradation [PROTEIN_M_Brn] → [none];   {none}
 
 PROTEIN_M_CAPK_degradation [PROTEIN_M_CAPK] → [