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BIOMD0000000224 - Meyer1991_CalciumSpike_ICC

 

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Reference Publication
Publication ID: 1867714
Meyer T, Stryer L.
Calcium spiking.
Annu Rev Biophys Biophys Chem 1991;20:153-74.
Department of Cell Biology, Sherman Fairchild Center, Stanford University School of Medicine, California 94305.  [more]
Model
Original Model: BIOMD0000000224.xml.origin
Submitter: Philipp Bayer
Submission ID: MODEL9412103933
Submission Date: 04 Aug 2009 19:55:09 UTC
Last Modification Date: 05 Oct 2009 11:39:32 UTC
Creation Date: 05 Aug 2009 13:17:56 UTC
Encoders:  Vijayalakshmi Chelliah
   Philipp Bayer
set #1
bqbiol:occursIn Taxonomy Rattus rattus
bqbiol:isVersionOf Gene Ontology regulation of release of sequestered calcium ion into cytosol
Notes

This a model from the article:
Calcium spiking.
Meyer T, Stryer L Annu Rev Biophys Biophys Chem1991:20:153-74 1867714,
Abstract:
No Abstract Available

The IP3-Ca2+ Crosscoupling Model (ICC) is reviewed by Meyer and Stryer in 1991, originally from Meyer and Stryer, 1988. PMID - 2455890 Parameters refer to figures 5 and 6 of the article which were reproduced by using Copasi 4.5 (Build 30). Species CaI and IP3 are buffered to 1% and 50% percent, respectively.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2012 The BioModels.net Team.
For more information see the terms of use.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 1867714 Submission Date: 04 Aug 2009 19:55:09 UTC Last Modification Date: 05 Oct 2009 11:39:32 UTC Creation Date: 05 Aug 2009 13:17:56 UTC
Mathematical expressions
Reactions
JChannel JPump kPLC kPhosphatase
inhibition_parameter1 inhibition_parameter2    
Physical entities
Compartments Species
cytosol CaI IP3 g
ER_store CaS    
Global parameters
A B C D
E F k1 k2
k3 L R  
Reactions (6)
 
 JChannel [CaS] → [CaI];   {IP3} , {g}
 
 JPump [CaI] → [CaS];  
 
 kPLC  → [IP3];   {CaI}
 
 kPhosphatase [IP3] → ;  
 
 inhibition_parameter1  → [g];   {CaI}
 
 inhibition_parameter2 [g] → ;   {CaI}
 
 cytosol Spatial dimensions: 3  Compartment size: 1.0
 
 CaI
Compartment: cytosol
Initial concentration: 0.1
 
 IP3
Compartment: cytosol
Initial concentration: 0.05
 
 g
Compartment: cytosol
Initial concentration: 0.0
 
 ER_store Spatial dimensions: 3  Compartment size: 1.0
 
 CaS
Compartment: ER_store
Initial concentration: 1100.0
 
Global Parameters (11)
 
   A
Value: 20.0   (Units: psec)
Constant
 
   B
Value: 40.0   (Units: microMpsec)
Constant
 
   C
Value: 1.1   (Units: microMpsec)
Constant
 
   D
Value: 2.0   (Units: psec)
Constant
 
   E
Value: 1.0   (Units: microM4)
Constant
 
   F
Value: 0.02   (Units: psec)
Constant
 
   k1
Value: 0.5   (Units: microM)
Constant
 
   k2
Value: 0.15   (Units: microM)
Constant
 
   k3
Value: 1.0   (Units: microM)
Constant
 
   L
Value: 0.01   (Units: psec)
Constant
 
   R
Value: 0.09
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000224

Curator's comment: (updated: 05 Aug 2009 15:12:36 BST)

Figure 6 of the reference publication is reproduced. The model was integrated and simulated using Copasi v4.5 (Build 30).

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