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BIOMD0000000224 - Meyer1991_CalciumSpike_ICC

 

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Reference Publication
Publication ID: 1867714
Meyer T, Stryer L.
Calcium spiking.
Annu Rev Biophys Biophys Chem 1991; 20: 153-174
Department of Cell Biology, Sherman Fairchild Center, Stanford University School of Medicine, California 94305.  [more]
Model
Original Model: BIOMD0000000224.xml.origin
Submitter: Philipp Bayer
Submission ID: MODEL9412103933
Submission Date: 04 Aug 2009 19:55:09 UTC
Last Modification Date: 28 May 2014 00:43:04 UTC
Creation Date: 05 Aug 2009 13:17:56 UTC
Encoders:  Vijayalakshmi Chelliah
   Philipp Bayer
set #1
bqmodel:isDerivedFrom PubMed 2455890
set #2
bqbiol:hasTaxon Taxonomy Rattus rattus
bqbiol:isVersionOf Gene Ontology regulation of release of sequestered calcium ion into cytosol
Notes

This a model from the article:
Calcium spiking.
Meyer T, Stryer L Annu Rev Biophys Biophys Chem1991:20:153-74 1867714,
Abstract:
No Abstract Available

The IP3-Ca2+ Crosscoupling Model (ICC) is reviewed by Meyer and Stryer in 1991, originally from Meyer and Stryer, 1988. PMID - 2455890 Parameters refer to figures 5 and 6 of the article which were reproduced by using Copasi 4.5 (Build 30). Species CaI and IP3 are buffered to 1% and 50% percent, respectively.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.
For more information see the terms of use.
To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

Model
Publication ID: 1867714 Submission Date: 04 Aug 2009 19:55:09 UTC Last Modification Date: 28 May 2014 00:43:04 UTC Creation Date: 05 Aug 2009 13:17:56 UTC
Mathematical expressions
Reactions
JChannel JPump kPLC kPhosphatase
inhibition_parameter1 inhibition_parameter2    
Physical entities
Compartments Species
cytosol CaI IP3 g
ER_store CaS    
Global parameters
A B C D
E F k1 k2
k3 L R  
Reactions (6)
 
 JChannel [CaS] → [CaI];   {IP3} , {g}
 
 JPump [CaI] → [CaS];  
 
 kPLC  → [IP3];   {CaI}
 
 kPhosphatase [IP3] → ;  
 
 inhibition_parameter1  → [g];   {CaI}
 
 inhibition_parameter2 [g] → ;   {CaI}
 
  Spatial dimensions: 3.0  Compartment size: 1.0
 
 CaI
Compartment: cytosol
Initial concentration: 0.1
 
 IP3
Compartment: cytosol
Initial concentration: 0.05
 
 g
Compartment: cytosol
Initial concentration: 0.0
 
  Spatial dimensions: 3.0  Compartment size: 1.0
 
 CaS
Compartment: ER_store
Initial concentration: 1100.0
 
Global Parameters (11)
 
   A
Value: 20.0   (Units: psec)
Constant
 
   B
Value: 40.0   (Units: microMpsec)
Constant
 
   C
Value: 1.1   (Units: microMpsec)
Constant
 
   D
Value: 2.0   (Units: psec)
Constant
 
   E
Value: 1.0   (Units: microM4)
Constant
 
   F
Value: 0.02   (Units: psec)
Constant
 
   k1
Value: 0.5   (Units: microM)
Constant
 
   k2
Value: 0.15   (Units: microM)
Constant
 
   k3
Value: 1.0   (Units: microM)
Constant
 
   L
Value: 0.01   (Units: psec)
Constant
 
   R
Value: 0.09
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000224

Curator's comment: (updated: 05 Aug 2009 15:12:36 BST)

Figure 6 of the reference publication is reproduced. The model was integrated and simulated using Copasi v4.5 (Build 30).

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