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BIOMD0000000205 - Ung2008_EGFR_Endocytosis

 

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Reference Publication
Publication ID: 18505685
Ung CY, Li H, Ma XH, Jia J, Li BW, Low BC, Chen YZ.
Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk.
FEBS Lett. 2008 Jun; 582(15): 2283-2290
Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, 3 Science Drive 2, Singapore 117543, Singapore.  [more]
Model
Original Model: BIOMD0000000205.xml.origin
Submitter: Harish Dharuri
Submission ID: MODEL7802538336
Submission Date: 27 Nov 2008 16:27:06 UTC
Last Modification Date: 31 May 2014 19:12:38 UTC
Creation Date: 27 Nov 2008 14:41:34 UTC
Encoders:  Harish Dharuri
   Chen Yu Zong
set #1
bqmodel:isDerivedFrom BioModels Database Sasagawa2005_MAPK
BioModels Database Kholodenko1999 - EGFR signaling
BioModels Database Schoeberl2002_EGF_MAPK
PubMed 14751248
PubMed 16687399
PubMed 11024454
set #2
bqbiol:hasTaxon Taxonomy Eukaryota
set #3
bqbiol:isPartOf KEGG Pathway hsa04070
KEGG Pathway hsa04010
set #4
bqbiol:isVersionOf Gene Ontology epidermal growth factor receptor signaling pathway
Gene Ontology endocytosis
Notes

Model reproduces the various plots in the publication for "Control" concentrations. Model successfully tested on MathSBML.

Model
Publication ID: 18505685 Submission Date: 27 Nov 2008 16:27:06 UTC Last Modification Date: 31 May 2014 19:12:38 UTC Creation Date: 27 Nov 2008 14:41:34 UTC
Mathematical expressions
Reactions
R1 R2 R3 R4
R5 R6 R7 R8
R9 R10 R11 R12
R13 R14 R15 R16
R17 R18 R19 R20
R21 R22 R23 R24
R25 R26 R27 R28
R29 R30 R31 R32
R33 R34 R35 R36
R37 R38 R39 R40
R41 R42 R43 R44
R45 R46 R47 R48
R49 R50 R51 R52
R53 R54 R55 R56
R57 R58 R59 R60
R61 R62 R63 R64
R65 R66 R67 R68
R69 R70 R71 R72
R73 R74 R75 R76
R77 R78 R79 R80
R81 R82 R83 R84
R85 R86 R87 R88
R89 R90 R91 R92
R93 R94 R95 R96
R97 R98 R99 R100
R101 R102 R103 R104
R105 R106 R107 R108
R109 R110 R111 R112
R113 R114 R115 R116
R117 R118 R119 R120
R121 R122 R123 R124
R125 R126 R127 R128
R129 R130 R131 R132
R133 R134 R135 R136
R137 R138 R139 R140
R141 R142 R143 R144
R145 R146 R147 R148
R149 R150 R151 R152
R153 R154 R155 R156
R157 R158 R159 R160
R161 R162 R163 R164
R165 R166 R167 R168
R169 R170 R171 R172
R173 R174 R175 R176
R177 R178 R179 R180
R181 R182 R183 R184
R185 R186 R187 R188
R189 R190 R191 R192
R193 R194 R195 R196
R197 R198 R199 R200
R201 R202 R203 R204
R205      
Physical entities
Compartments Species
Cell EGF EGFR EGF-EGFR
EGF-EGFR-2 EGF-pEGFR-2 SHP
EGF-pEGFR-2-SHP Shc EGF-pEGFR-2-Shc
EGF-pEGFR-2-pShc pShc pShc-SHP
Grb2 EGF-pEGFR-2-pShc-Grb2 SOS
EGF-pEGFR-2-pShc-Grb2-SOS Grb2-SOS RasGDP
EGF-pEGFR-2-pShc-Grb2-SOS-RasGDP RasGTP EGF-pEGFR-2-Grb2
EGF-pEGFR-2-Grb2-SOS EGF-pEGFR-2-Grb2-SOS-RasGDP Raf
Raf-RasGTP pRaf MEK
pRaf-MEK pMEK pRaf-pMEK
ppMEK ERK ppMEK-ERK
pERK ppMEK-pERK ppERK
Pase pRaf-Pase PP2A
ppMEK-PP2A pMEK-PP2A MKP3
ppERK-MKP3 pERK-MKP3 RasGAP
RasGTP-RasGAP ppERK-EGF-pEGFR-2-pShc-Grb2-SOS pSOS
ppERK-EGF-pEGFR-2-Grb2-SOS PI3K EGF-pEGFR-2-PI3K
EGF-pEGFF-2 pPI3K TP4
pPI3K-TP4 PIP2 pPI3K-PIP2
PIP3 Akt Akt-PIP3
PDK1 Akt-PIP3-PDK1 pAkt-PIP3
pAkt Takt pAkt-PIP3-Takt
pRaf-pAkt-PIP3 ppRaf pROK
PTEN pROK-PTEN pPTEN
pPTEN-PIP3 RacGEF PIP3-RacGEF
RacGDP PIP3-RacGEF-RacGDP RacGTP
RhoGDI RhoGDI-RacGDP RacGAP
RacGTP-RacGAP RhoGDP RhoGDP-RhoGDI
pRhoGEF RhoGDP-pRhoGEF RhoGTP
EGF-pEGFR-2-RasGAP EGF-pEGFR-2-RasGAP-RasGTP EGF-pEGFR2-RasGAP
SHP2 EGF-pEGFR-2-pShc-Grb2-SHP2 EGF-pEGFR-2-Grb2-SHP2
EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGEF RhoGEF pRhoGAP
EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGAP RhoGAP EGF-pEGFR-2-Grb2-SHP2-pRhoGEF
EGF-pEGFR-2-Grb2-SHP2-pRhoGAP EGF-pEGFR-2-RasGAP-SHP2 pSrc
pSrc-RhoGEF pSrc-RhoGAP pRhoGAP-RhoGTP
ROK RhoGTP-ROK Src
EGF-pEGFR-2-Src EGF-pEGFR-2-pSrc EGF-pEGRF-2
TP7 pSrc-TP7 Src-TP7
Cbl-CIN85 EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85 EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85
EPn EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85-EPn EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85-EPn
EGF-pEGFR-2-degrade pShc-Grb2-SOS Pro-EGFR
pROK-EPn pEPn MPase
pEPn-MPase pEPn-Mpase Ras-GTP-RhoGEF
ppERK-pROK MEKK1abcdef Grb2-MEKK1abcdef
EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef EGF-pEGFR-2-Grb2-MEKK1abcdef EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdef
EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdef EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef EGF-pEGFR-2-Grb2-MEKK1abMEKcdef
EGF-pEGFR-2-Grb2-MEKK1abpMEKcdef EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef
EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdef EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbpMEKcdef EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdef
EGF-pEGFR-2-Grb2-MEKK1aRafbcdef EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdef EGF-pEGFR-2-Grb2-MEKK1aRafbpMEKcdef
EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef EGF-pEGFR-2-pShc-Grb2-MEKK1abcdefRasGTP EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdefRasGTP
EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdefRasGTP EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdefRasGTP EGF-pEGFR-2-Grb2-MEKK1abcdefRasGTP
EGF-pEGFR-2-Grb2-MEKK1abMEKcdefRasGTP EGF-pEGFR-2-Grb2-MEKK1abpMEKcdefRasGTP EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP
EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcERKdefRasGTP EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcpERKdefRasGTP EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcppERKdefRasGTP
EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdefRasGTP EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdefRasGTP EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdefRasGTP
EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbcdef EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbMEKcdef EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbpMEKcdef
EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbppMEKcdef EGF-pEGFR-2-Grb2-MEKK1apRafbcdef EGF-pEGFR-2-Grb2-MEKK1apRafbMEKcdef
EGF-pEGFR-2-Grb2-MEKK1apRafbpMEKcdef EGF-pEGFR-2-Grb2-MEKK1apRafbppMEKcdef EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdRhoGTPef
EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdRhoGTPef EGF-pEGFR-2-Grb2-MEKK1abMEKcdRhoGTPef EGF-pEGFR-2-Grb2-MEKK1abppMEKcdRhoGTPef
EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdRhoGTPef EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdRhoGTPef EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdRhoGTPef
EGF-pEGFR-2-Grb2-MEKK1aRafbcdRhoGTPef EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcERKdef EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcpERKdef
EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcppERKdef EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdef EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdef
EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdef EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcERKdef EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcpERKdef
EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcppERKdef EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcERKdef EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcpERKdef
EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcppERKdef EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdRhoGTPepRhoGAPf EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdRhoGTPepRhoGAPf
EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdRhoGTPepRhoGAPf EGF-pEGFR-2-Grb2-MEKK1aRafbcdRhoGTPepRhoGAPf  
Reactions (205)
 
 R1 [EGF] + [EGFR] ↔ [EGF-EGFR];  
 
 R2 2.0 × [EGF-EGFR] ↔ [EGF-EGFR-2];  
 
 R3 [EGF-EGFR-2] → [EGF-pEGFR-2];  
 
 R4 [EGF-pEGFR-2] + [SHP] ↔ [EGF-pEGFR-2-SHP];  
 
 R5 [EGF-pEGFR-2-SHP] → [EGF-EGFR-2] + [SHP];  
 
 R6 [EGF-pEGFR-2] + [Shc] ↔ [EGF-pEGFR-2-Shc];  
 
 R7 [EGF-pEGFR-2-Shc] → [EGF-pEGFR-2-pShc];  
 
 R8 [EGF-pEGFR-2-pShc] ↔ [EGF-pEGFR-2] + [pShc];  
 
 R9 [pShc] + [SHP] ↔ [pShc-SHP];  
 
 R10 [pShc-SHP] → [Shc] + [SHP];  
 
 R11 [EGF-pEGFR-2-pShc] + [Grb2] ↔ [EGF-pEGFR-2-pShc-Grb2];  
 
 R12 [EGF-pEGFR-2-pShc-Grb2] + [SOS] ↔ [EGF-pEGFR-2-pShc-Grb2-SOS];  
 
 R13 [Grb2] + [SOS] ↔ [Grb2-SOS];  
 
 R14 [EGF-pEGFR-2-pShc] + [Grb2-SOS] ↔ [EGF-pEGFR-2-pShc-Grb2-SOS];  
 
 R15 [EGF-pEGFR-2-pShc-Grb2-SOS] + [RasGDP] ↔ [EGF-pEGFR-2-pShc-Grb2-SOS-RasGDP];  
 
 R16 [EGF-pEGFR-2-pShc-Grb2-SOS-RasGDP] → [EGF-pEGFR-2-pShc-Grb2-SOS] + [RasGTP];  
 
 R17 [EGF-pEGFR-2] + [Grb2] ↔ [EGF-pEGFR-2-Grb2];  
 
 R18 [EGF-pEGFR-2-Grb2] + [SOS] ↔ [EGF-pEGFR-2-Grb2-SOS];  
 
 R19 [EGF-pEGFR-2] + [Grb2-SOS] ↔ [EGF-pEGFR-2-Grb2-SOS];  
 
 R20 [EGF-pEGFR-2-Grb2-SOS] + [RasGDP] ↔ [EGF-pEGFR-2-Grb2-SOS-RasGDP];  
 
 R21 [EGF-pEGFR-2-Grb2-SOS-RasGDP] → [EGF-pEGFR-2-Grb2-SOS] + [RasGTP];  
 
 R22 [Raf] + [RasGTP] ↔ [Raf-RasGTP];  
 
 R23 [Raf-RasGTP] → [pRaf] + [RasGTP];  
 
 R24 [pRaf] + [MEK] ↔ [pRaf-MEK];  
 
 R25 [pRaf-MEK] → [pRaf] + [pMEK];  
 
 R26 [pRaf] + [pMEK] ↔ [pRaf-pMEK];  
 
 R27 [pRaf-pMEK] → [pRaf] + [ppMEK];  
 
 R28 [ppMEK] + [ERK] ↔ [ppMEK-ERK];  
 
 R29 [ppMEK-ERK] → [ppMEK] + [pERK];  
 
 R30 [ppMEK] + [pERK] ↔ [ppMEK-pERK];  
 
 R31 [ppMEK-pERK] → [ppMEK] + [ppERK];  
 
 R32 [pRaf] + [Pase] ↔ [pRaf-Pase];  
 
 R33 [pRaf-Pase] → [Raf] + [Pase];  
 
 R34 [ppMEK] + [PP2A] ↔ [ppMEK-PP2A];  
 
 R35 [ppMEK-PP2A] → [pMEK] + [PP2A];  
 
 R36 [pMEK] + [PP2A] ↔ [pMEK-PP2A];  
 
 R37 [pMEK-PP2A] → [MEK] + [PP2A];  
 
 R38 [ppERK] + [MKP3] ↔ [ppERK-MKP3];  
 
 R39 [ppERK-MKP3] → [pERK] + [MKP3];  
 
 R40 [pERK] + [MKP3] ↔ [pERK-MKP3];  
 
 R41 [pERK-MKP3] → [ERK] + [MKP3];  
 
 R42 [RasGTP] → [RasGDP];  
 
 R43 [RasGTP] + [RasGAP] ↔ [RasGTP-RasGAP];  
 
 R44 [RasGTP-RasGAP] → [RasGDP] + [RasGAP];  
 
 R45 [ppERK] + [EGF-pEGFR-2-pShc-Grb2-SOS] ↔ [ppERK-EGF-pEGFR-2-pShc-Grb2-SOS];  
 
 R46 [ppERK-EGF-pEGFR-2-pShc-Grb2-SOS] → [ppERK] + [EGF-pEGFR-2] + [pShc] + [Grb2] + [pSOS];  
 
 R47 [ppERK] + [EGF-pEGFR-2-Grb2-SOS] ↔ [ppERK-EGF-pEGFR-2-Grb2-SOS];  
 
 R48 [ppERK-EGF-pEGFR-2-Grb2-SOS] → [ppERK] + [EGF-pEGFR-2] + [Grb2] + [pSOS];  
 
 R49 [pSOS] → [SOS];  
 
 R50 [EGF-pEGFR-2] + [PI3K] ↔ [EGF-pEGFR-2-PI3K];  
 
 R51 [EGF-pEGFR-2-PI3K] → [EGF-pEGFF-2] + [pPI3K];  
 
 R52 [pPI3K] + [TP4] ↔ [pPI3K-TP4];  
 
 R53 [pPI3K-TP4] → [PI3K] + [TP4];  
 
 R54 [pPI3K] + [PIP2] ↔ [pPI3K-PIP2];  
 
 R55 [pPI3K-PIP2] → [pPI3K] + [PIP3];  
 
 R56 [Akt] + [PIP3] ↔ [Akt-PIP3];  
 
 R57 [Akt-PIP3] + [PDK1] ↔ [Akt-PIP3-PDK1];  
 
 R58 [Akt-PIP3-PDK1] → [pAkt-PIP3] + [PDK1];  
 
 R59 [pAkt-PIP3] ↔ [pAkt] + [PIP3];  
 
 R60 [pAkt-PIP3] + [Takt] ↔ [pAkt-PIP3-Takt];  
 
 R61 [pAkt-PIP3-Takt] → [Akt-PIP3] + [Takt];  
 
 R62 [pRaf] + [pAkt-PIP3] ↔ [pRaf-pAkt-PIP3];  
 
 R63 [pRaf-pAkt-PIP3] → [ppRaf] + [pAkt-PIP3];  
 
 R64 [ppRaf] → [pRaf];  
 
 R65 [pROK] + [PTEN] ↔ [pROK-PTEN];  
 
 R66 [pROK-PTEN] → [pROK] + [pPTEN];  
 
 R67 [pPTEN] + [PIP3] ↔ [pPTEN-PIP3];  
 
 R68 [pPTEN-PIP3] → [pPTEN] + [PIP2];  
 
 R69 [pPTEN] → [PTEN];  
 
 R70 [PIP3] → [PIP2];  
 
 R71 [PIP3] + [RacGEF] ↔ [PIP3-RacGEF];  
 
 R72 [PIP3-RacGEF] + [RacGDP] ↔ [PIP3-RacGEF-RacGDP];  
 
 R73 [PIP3-RacGEF-RacGDP] → [PIP3-RacGEF] + [RacGTP];  
 
 R74 [RhoGDI] + [RacGDP] ↔ [RhoGDI-RacGDP];  
 
 R75 [RacGTP] → [RacGDP];  
 
 R76 [RacGTP] + [RacGAP] ↔ [RacGTP-RacGAP];  
 
 R77 [RacGTP-RacGAP] → [RacGDP] + [RacGAP];  
 
 R78 [RhoGDP] + [RhoGDI] ↔ [RhoGDP-RhoGDI];  
 
 R79 [RhoGDP] + [pRhoGEF] ↔ [RhoGDP-pRhoGEF];  
 
 R80 [RhoGDP-pRhoGEF] → [RhoGTP] + [pRhoGEF];  
 
 R81 [RhoGTP] → [RhoGDP];  
 
 R82 [EGF-pEGFR-2] + [RasGAP] ↔ [EGF-pEGFR-2-RasGAP];  
 
 R83 [EGF-pEGFR-2-RasGAP] + [RasGTP] ↔ [EGF-pEGFR-2-RasGAP-RasGTP];  
 
 R84 [EGF-pEGFR-2-RasGAP-RasGTP] → [EGF-pEGFR2-RasGAP] + [RasGDP];  
 
 R85 [EGF-pEGFR-2-pShc-Grb2] + [SHP2] ↔ [EGF-pEGFR-2-pShc-Grb2-SHP2];  
 
 R86 [EGF-pEGFR-2-Grb2] + [SHP2] ↔ [EGF-pEGFR-2-Grb2-SHP2];  
 
 R87 [EGF-pEGFR-2-pShc-Grb2-SHP2] → [EGF-EGFR-2] + [pShc] + [Grb2] + [SHP2];  
 
 R88 [EGF-pEGFR-2-Grb2-SHP2] → [EGF-EGFR-2] + [Grb2] + [SHP2];  
 
 R89 [EGF-pEGFR-2-pShc-Grb2-SHP2] + [pRhoGEF] ↔ [EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGEF];  
 
 R90 [EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGEF] → [EGF-pEGFR-2-pShc-Grb2-SHP2] + [RhoGEF];  
 
 R91 [EGF-pEGFR-2-pShc-Grb2-SHP2] + [pRhoGAP] ↔ [EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGAP];  
 
 R92 [EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGAP] → [EGF-pEGFR-2-pShc-Grb2-SHP2] + [RhoGAP];  
 
 R93 [EGF-pEGFR-2-Grb2-SHP2] + [pRhoGEF] ↔ [EGF-pEGFR-2-Grb2-SHP2-pRhoGEF];  
 
 R94 [EGF-pEGFR-2-Grb2-SHP2-pRhoGEF] → [EGF-pEGFR-2-Grb2-SHP2] + [RhoGEF];  
 
 R95 [EGF-pEGFR-2-Grb2-SHP2] + [pRhoGAP] ↔ [EGF-pEGFR-2-Grb2-SHP2-pRhoGAP];  
 
 R96 [EGF-pEGFR-2-Grb2-SHP2-pRhoGAP] → [EGF-pEGFR-2-Grb2-SHP2] + [RhoGAP];  
 
 R97 [EGF-pEGFR-2-RasGAP] + [SHP2] ↔ [EGF-pEGFR-2-RasGAP-SHP2];  
 
 R98 [EGF-pEGFR-2-RasGAP-SHP2] → [EGF-EGFR-2] + [RasGAP] + [SHP2];  
 
 R99 [pSrc] + [RhoGEF] ↔ [pSrc-RhoGEF];  
 
 R100 [pSrc-RhoGEF] → [pSrc] + [pRhoGEF];  
 
 R101 [pRhoGEF] → [RhoGEF];  
 
 R102 [pSrc] + [RhoGAP] ↔ [pSrc-RhoGAP];  
 
 R103 [pSrc-RhoGAP] → [pSrc] + [pRhoGAP];  
 
 R104 [pRhoGAP] + [RhoGTP] ↔ [pRhoGAP-RhoGTP];  
 
 R105 [pRhoGAP-RhoGTP] → [pRhoGAP] + [RhoGDP];  
 
 R106 [RhoGTP] + [ROK] ↔ [RhoGTP-ROK];  
 
 R107 [RhoGTP-ROK] → [RhoGTP] + [pROK];  
 
 R108 [EGF-pEGFR-2] + [Src] ↔ [EGF-pEGFR-2-Src];  
 
 R109 [EGF-pEGFR-2-Src] → [EGF-pEGFR-2-pSrc];  
 
 R110 [EGF-pEGFR-2] ↔ [EGF-pEGRF-2] + [pSrc];  
 
 R111 [pSrc] + [TP7] ↔ [pSrc-TP7];  
 
 R112 [pSrc-TP7] → [Src-TP7];  
 
 R113 [Src-TP7] ↔ [Src] + [TP7];  
 
 R114 [EGF-pEGFR-2-pShc-Grb2-SOS] + [Cbl-CIN85] ↔ [EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85];  
 
 R115 [EGF-pEGFR-2-Grb2-SOS] + [Cbl-CIN85] ↔ [EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85];  
 
 R116 [EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85] + [EPn] ↔ [EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85-EPn];  
 
 R117 [EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85] + [EPn] ↔ [EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85-EPn];  
 
 R118 [EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85-EPn] → [EGF-pEGFR-2-degrade] + [Cbl-CIN85] + [EPn] + [pShc-Grb2-SOS];  
 
 R119 [EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85-EPn] → [EGF-pEGFR-2-degrade] + [Cbl-CIN85] + [EPn] + [Grb2-SOS];  
 
 R120 [Pro-EGFR] → [EGFR];  
 
 R121 [pROK] + [EPn] ↔ [pROK-EPn];  
 
 R122 [pROK-EPn] → [pROK] + [pEPn];  
 
 R123 [pEPn] + [MPase] ↔ [pEPn-MPase];  
 
 R124 [pEPn-Mpase] → [EPn] + [MPase];  
 
 R125 [RasGTP] + [RhoGEF] ↔ [Ras-GTP-RhoGEF];  
 
 R126 [Ras-GTP-RhoGEF] → [RasGTP] + [pRhoGEF];  
 
 R127 [ppERK] + [pROK] ↔ [ppERK-pROK];  
 
 R128 [ppERK-pROK] → [ppERK] + [ROK];  
 
 R129 [Grb2] + [MEKK1abcdef] ↔ [Grb2-MEKK1abcdef];  
 
 R130 [EGF-pEGFR-2-pShc] + [Grb2-MEKK1abcdef] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef];  
 
 R131 [EGF-pEGFR-2] + [Grb2-MEKK1abcdef] ↔ [EGF-pEGFR-2-Grb2-MEKK1abcdef];  
 
 R132 [EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef] + [MEK] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdef];  
 
 R133 [EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdef];  
 
 R134 [EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef];  
 
 R135 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef] + [ppMEK];  
 
 R136 [EGF-pEGFR-2-Grb2-MEKK1abcdef] + [MEK] ↔ [EGF-pEGFR-2-Grb2-MEKK1abMEKcdef];  
 
 R137 [EGF-pEGFR-2-Grb2-MEKK1abMEKcdef] → [EGF-pEGFR-2-Grb2-MEKK1abpMEKcdef];  
 
 R138 [EGF-pEGFR-2-Grb2-MEKK1abpMEKcdef] → [EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef];  
 
 R139 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef] ↔ [EGF-pEGFR-2-Grb2-MEKK1abcdef] + [ppMEK];  
 
 R140 [EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef] + [Raf] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef];  
 
 R141 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef] + [MEK] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdef];  
 
 R142 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbpMEKcdef];  
 
 R143 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbpMEKcdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdef];  
 
 R144 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdef] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef] + [ppMEK];  
 
 R145 [EGF-pEGFR-2-Grb2-MEKK1abcdef] + [Raf] ↔ [EGF-pEGFR-2-Grb2-MEKK1aRafbcdef];  
 
 R146 [EGF-pEGFR-2-Grb2-MEKK1aRafbcdef] + [MEK] ↔ [EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdef];  
 
 R147 [EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdef] → [EGF-pEGFR-2-Grb2-MEKK1aRafbpMEKcdef];  
 
 R148 [EGF-pEGFR-2-Grb2-MEKK1aRafbpMEKcdef] → [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef];  
 
 R149 [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef] ↔ [EGF-pEGFR-2-Grb2-MEKK1aRafbcdef] + [ppMEK];  
 
 R150 [EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef] + [RasGTP] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1abcdefRasGTP];  
 
 R151 [EGF-pEGFR-2-pShc-Grb2-MEKK1abcdefRasGTP] + [MEK] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdefRasGTP];  
 
 R152 [EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdefRasGTP] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdefRasGTP];  
 
 R153 [EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdefRasGTP] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdefRasGTP];  
 
 R154 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdefRasGTP] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1abcdefRasGTP] + [ppMEK];  
 
 R155 [EGF-pEGFR-2-Grb2-MEKK1abcdef] + [RasGTP] ↔ [EGF-pEGFR-2-Grb2-MEKK1abcdefRasGTP];  
 
 R156 [EGF-pEGFR-2-Grb2-MEKK1abcdefRasGTP] + [MEK] ↔ [EGF-pEGFR-2-Grb2-MEKK1abMEKcdefRasGTP];  
 
 R157 [EGF-pEGFR-2-Grb2-MEKK1abMEKcdefRasGTP] → [EGF-pEGFR-2-Grb2-MEKK1abpMEKcdefRasGTP];  
 
 R158 [EGF-pEGFR-2-Grb2-MEKK1abpMEKcdefRasGTP] → [EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP];  
 
 R159 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP] ↔ [EGF-pEGFR-2-Grb2-MEKK1abcdefRasGTP] + [ppMEK];  
 
 R160 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdefRasGTP] + [ERK] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcERKdefRasGTP];  
 
 R161 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcERKdefRasGTP] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcpERKdefRasGTP];  
 
 R162 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcpERKdefRasGTP] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcppERKdefRasGTP];  
 
 R163 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcppERKdefRasGTP] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdefRasGTP] + [ppERK];  
 
 R164 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP] + [ERK] ↔ [EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdefRasGTP];  
 
 R165 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdefRasGTP] → [EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdefRasGTP];  
 
 R166 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdefRasGTP] → [EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdefRasGTP];  
 
 R167 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdefRasGTP] → [EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP] + [ppERK];  
 
 R168 [EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef] + [pRaf] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbcdef];  
 
 R169 [EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbcdef] + [MEK] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbMEKcdef];  
 
 R170 [EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbMEKcdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbpMEKcdef];  
 
 R171 [EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbpMEKcdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbppMEKcdef];  
 
 R172 [EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbppMEKcdef] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbcdef] + [ppMEK];  
 
 R173 [EGF-pEGFR-2-Grb2-MEKK1abcdef] + [pRaf] ↔ [EGF-pEGFR-2-Grb2-MEKK1apRafbcdef];  
 
 R174 [EGF-pEGFR-2-Grb2-MEKK1apRafbcdef] + [MEK] ↔ [EGF-pEGFR-2-Grb2-MEKK1apRafbMEKcdef];  
 
 R175 [EGF-pEGFR-2-Grb2-MEKK1apRafbMEKcdef] → [EGF-pEGFR-2-Grb2-MEKK1apRafbpMEKcdef];  
 
 R176 [EGF-pEGFR-2-Grb2-MEKK1apRafbpMEKcdef] → [EGF-pEGFR-2-Grb2-MEKK1apRafbppMEKcdef];  
 
 R177 [EGF-pEGFR-2-Grb2-MEKK1apRafbppMEKcdef] ↔ [EGF-pEGFR-2-Grb2-MEKK1apRafbcdef] + [ppMEK];  
 
 R178 [EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdef] + [RhoGTP] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdRhoGTPef];  
 
 R179 [EGF-pEGFR-2-Grb2-MEKK1abMEKcdef] + [RhoGTP] ↔ [EGF-pEGFR-2-Grb2-MEKK1abMEKcdRhoGTPef];  
 
 R180 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdef] + [RhoGTP] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdRhoGTPef];  
 
 R181 [EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdef] + [RhoGTP] ↔ [EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdRhoGTPef];  
 
 R182 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef] + [ERK] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcERKdef];  
 
 R183 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcERKdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcpERKdef];  
 
 R184 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcpERKdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcppERKdef];  
 
 R185 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcppERKdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef] + [ppERK];  
 
 R186 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef] + [ERK] ↔ [EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdef];  
 
 R187 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdef] → [EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdef];  
 
 R188 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdef] → [EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdef];  
 
 R189 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdef] → [EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef] + [ppERK];  
 
 R190 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdef] + [ERK] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcERKdef];  
 
 R191 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcERKdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcpERKdef];  
 
 R192 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcpERKdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcppERKdef];  
 
 R193 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcppERKdef] → [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdef] + [ppERK];  
 
 R194 [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef] + [ERK] ↔ [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcERKdef];  
 
 R195 [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcERKdef] → [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcpERKdef];  
 
 R196 [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcpERKdef] → [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcppERKdef];  
 
 R197 [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcppERKdef] → [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef] + [ppERK];  
 
 R198 [EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdRhoGTPef] + [pRhoGAP] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdRhoGTPepRhoGAPf];  
 
 R199 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdRhoGTPepRhoGAPf] → [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdef] + [RhoGDP] + [pRhoGAP];  
 
 R200 [EGF-pEGFR-2-Grb2-MEKK1abppMEKcdRhoGTPef] + [pRhoGAP] ↔ [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdRhoGTPepRhoGAPf];  
 
 R201 [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdRhoGTPepRhoGAPf] → [EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef] + [RhoGDP] + [pRhoGAP];  
 
 R202 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdRhoGTPef] + [pRhoGAP] ↔ [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdRhoGTPepRhoGAPf];  
 
 R203 [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdRhoGTPepRhoGAPf] → [EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef] + [RhoGDP] + [pRhoGAP];  
 
 R204 [EGF-pEGFR-2-Grb2-MEKK1aRafbcdRhoGTPef] + [pRhoGAP] ↔ [EGF-pEGFR-2-Grb2-MEKK1aRafbcdRhoGTPepRhoGAPf];  
 
 R205 [EGF-pEGFR-2-Grb2-MEKK1aRafbcdRhoGTPepRhoGAPf] → [EGF-pEGFR-2-Grb2-MEKK1aRafbcdef] + [RhoGDP] + [pRhoGAP];  
 
 Cell Spatial dimensions: 3.0  Compartment size: 1.0
 
 EGF
Compartment: Cell
Initial concentration: 0.0081967
 
 EGFR
Compartment: Cell
Initial concentration: 0.3
 
 EGF-EGFR
Compartment: Cell
Initial concentration: 0.0
 
 EGF-EGFR-2
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2
Compartment: Cell
Initial concentration: 0.0
 
 SHP
Compartment: Cell
Initial concentration: 0.1
 
 EGF-pEGFR-2-SHP
Compartment: Cell
Initial concentration: 0.0
 
 Shc
Compartment: Cell
Initial concentration: 1.0
 
 EGF-pEGFR-2-Shc
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc
Compartment: Cell
Initial concentration: 0.0
 
 pShc
Compartment: Cell
Initial concentration: 0.0
 
 pShc-SHP
Compartment: Cell
Initial concentration: 0.0
 
 Grb2
Compartment: Cell
Initial concentration: 1.0
 
 EGF-pEGFR-2-pShc-Grb2
Compartment: Cell
Initial concentration: 0.0
 
 SOS
Compartment: Cell
Initial concentration: 0.3
 
 EGF-pEGFR-2-pShc-Grb2-SOS
Compartment: Cell
Initial concentration: 0.0
 
 Grb2-SOS
Compartment: Cell
Initial concentration: 0.0
 
 RasGDP
Compartment: Cell
Initial concentration: 0.15
 
 EGF-pEGFR-2-pShc-Grb2-SOS-RasGDP
Compartment: Cell
Initial concentration: 0.0
 
 RasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-SOS
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-SOS-RasGDP
Compartment: Cell
Initial concentration: 0.0
 
 Raf
Compartment: Cell
Initial concentration: 0.5
 
 Raf-RasGTP
Compartment: Cell
Initial concentration: 0.0
 
 pRaf
Compartment: Cell
Initial concentration: 0.0
 
 MEK
Compartment: Cell
Initial concentration: 0.68
 
 pRaf-MEK
Compartment: Cell
Initial concentration: 0.0
 
 pMEK
Compartment: Cell
Initial concentration: 0.0
 
 pRaf-pMEK
Compartment: Cell
Initial concentration: 0.0
 
 ppMEK
Compartment: Cell
Initial concentration: 0.0
 
 ERK
Compartment: Cell
Initial concentration: 0.4
 
 ppMEK-ERK
Compartment: Cell
Initial concentration: 0.0
 
 pERK
Compartment: Cell
Initial concentration: 0.0
 
 ppMEK-pERK
Compartment: Cell
Initial concentration: 0.0
 
 ppERK
Compartment: Cell
Initial concentration: 0.0
 
   Pase
Compartment: Cell
Initial concentration: 0.5
 
 pRaf-Pase
Compartment: Cell
Initial concentration: 0.0
 
 PP2A
Compartment: Cell
Initial concentration: 0.02
 
 ppMEK-PP2A
Compartment: Cell
Initial concentration: 0.0
 
 pMEK-PP2A
Compartment: Cell
Initial concentration: 0.0
 
 MKP3
Compartment: Cell
Initial concentration: 0.0020
 
 ppERK-MKP3
Compartment: Cell
Initial concentration: 0.0
 
 pERK-MKP3
Compartment: Cell
Initial concentration: 0.0
 
 RasGAP
Compartment: Cell
Initial concentration: 0.1
 
 RasGTP-RasGAP
Compartment: Cell
Initial concentration: 0.0
 
 ppERK-EGF-pEGFR-2-pShc-Grb2-SOS
Compartment: Cell
Initial concentration: 0.0
 
 pSOS
Compartment: Cell
Initial concentration: 0.0
 
 ppERK-EGF-pEGFR-2-Grb2-SOS
Compartment: Cell
Initial concentration: 0.0
 
 PI3K
Compartment: Cell
Initial concentration: 0.01
 
 EGF-pEGFR-2-PI3K
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFF-2
Compartment: Cell
Initial concentration: 0.0
 
 pPI3K
Compartment: Cell
Initial concentration: 0.0
 
   TP4
Compartment: Cell
Initial concentration: 0.2
 
 pPI3K-TP4
Compartment: Cell
Initial concentration: 0.0
 
 PIP2
Compartment: Cell
Initial concentration: 0.5
 
 pPI3K-PIP2
Compartment: Cell
Initial concentration: 0.0
 
 PIP3
Compartment: Cell
Initial concentration: 0.5
 
 Akt
Compartment: Cell
Initial concentration: 0.1
 
 Akt-PIP3
Compartment: Cell
Initial concentration: 0.0
 
 PDK1
Compartment: Cell
Initial concentration: 0.1
 
 Akt-PIP3-PDK1
Compartment: Cell
Initial concentration: 0.0
 
 pAkt-PIP3
Compartment: Cell
Initial concentration: 0.0
 
 pAkt
Compartment: Cell
Initial concentration: 0.0
 
   Takt
Compartment: Cell
Initial concentration: 0.1
 
 pAkt-PIP3-Takt
Compartment: Cell
Initial concentration: 0.0
 
 pRaf-pAkt-PIP3
Compartment: Cell
Initial concentration: 0.0
 
 ppRaf
Compartment: Cell
Initial concentration: 0.0
 
 pROK
Compartment: Cell
Initial concentration: 0.0
 
 PTEN
Compartment: Cell
Initial concentration: 0.1
 
 pROK-PTEN
Compartment: Cell
Initial concentration: 0.0
 
 pPTEN
Compartment: Cell
Initial concentration: 0.0
 
 pPTEN-PIP3
Compartment: Cell
Initial concentration: 0.0
 
 RacGEF
Compartment: Cell
Initial concentration: 0.1
 
 PIP3-RacGEF
Compartment: Cell
Initial concentration: 0.0
 
 RacGDP
Compartment: Cell
Initial concentration: 0.2
 
 PIP3-RacGEF-RacGDP
Compartment: Cell
Initial concentration: 0.0
 
 RacGTP
Compartment: Cell
Initial concentration: 0.0
 
 RhoGDI
Compartment: Cell
Initial concentration: 0.1
 
 RhoGDI-RacGDP
Compartment: Cell
Initial concentration: 0.0
 
   RacGAP
Compartment: Cell
Initial concentration: 0.1
 
 RacGTP-RacGAP
Compartment: Cell
Initial concentration: 0.0
 
 RhoGDP
Compartment: Cell
Initial concentration: 0.15
 
 RhoGDP-RhoGDI
Compartment: Cell
Initial concentration: 0.0
 
 pRhoGEF
Compartment: Cell
Initial concentration: 0.0
 
 RhoGDP-pRhoGEF
Compartment: Cell
Initial concentration: 0.0
 
 RhoGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-RasGAP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-RasGAP-RasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR2-RasGAP
Compartment: Cell
Initial concentration: 0.0
 
 SHP2
Compartment: Cell
Initial concentration: 0.1
 
 EGF-pEGFR-2-pShc-Grb2-SHP2
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-SHP2
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGEF
Compartment: Cell
Initial concentration: 0.0
 
 RhoGEF
Compartment: Cell
Initial concentration: 0.1
 
   pRhoGAP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGAP
Compartment: Cell
Initial concentration: 0.0
 
   RhoGAP
Compartment: Cell
Initial concentration: 0.5
 
 EGF-pEGFR-2-Grb2-SHP2-pRhoGEF
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-SHP2-pRhoGAP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-RasGAP-SHP2
Compartment: Cell
Initial concentration: 0.0
 
 pSrc
Compartment: Cell
Initial concentration: 0.0
 
 pSrc-RhoGEF
Compartment: Cell
Initial concentration: 0.0
 
 pSrc-RhoGAP
Compartment: Cell
Initial concentration: 0.0
 
 pRhoGAP-RhoGTP
Compartment: Cell
Initial concentration: 0.0
 
 ROK
Compartment: Cell
Initial concentration: 0.68
 
 RhoGTP-ROK
Compartment: Cell
Initial concentration: 0.0
 
 Src
Compartment: Cell
Initial concentration: 0.518
 
 EGF-pEGFR-2-Src
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pSrc
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGRF-2
Compartment: Cell
Initial concentration: 0.0
 
   TP7
Compartment: Cell
Initial concentration: 0.518
 
 pSrc-TP7
Compartment: Cell
Initial concentration: 0.0
 
 Src-TP7
Compartment: Cell
Initial concentration: 0.0
 
 Cbl-CIN85
Compartment: Cell
Initial concentration: 0.8
 
 EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85
Compartment: Cell
Initial concentration: 0.0
 
 EPn
Compartment: Cell
Initial concentration: 0.5
 
 EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85-EPn
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85-EPn
Compartment: Cell
Initial concentration: 0.0
 
   EGF-pEGFR-2-degrade
Compartment: Cell
Initial concentration: 0.0
 
 pShc-Grb2-SOS
Compartment: Cell
Initial concentration: 0.0
 
 Pro-EGFR
Compartment: Cell
Initial concentration: 3000.0
 
 pROK-EPn
Compartment: Cell
Initial concentration: 0.0
 
 pEPn
Compartment: Cell
Initial concentration: 0.0
 
   MPase
Compartment: Cell
Initial concentration: 1.0
 
 pEPn-MPase
Compartment: Cell
Initial concentration: 0.0
 
 pEPn-Mpase
Compartment: Cell
Initial concentration: 0.0
 
   Ras-GTP-RhoGEF
Compartment: Cell
Initial concentration: 0.0
 
 ppERK-pROK
Compartment: Cell
Initial concentration: 0.0
 
 MEKK1abcdef
Compartment: Cell
Initial concentration: 0.5
 
 Grb2-MEKK1abcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abpMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbpMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbpMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abcdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abcdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abMEKcdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abpMEKcdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcERKdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcpERKdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcppERKdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdefRasGTP
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbpMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbppMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1apRafbcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1apRafbMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1apRafbpMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1apRafbppMEKcdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdRhoGTPef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdRhoGTPef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abMEKcdRhoGTPef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abppMEKcdRhoGTPef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdRhoGTPef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdRhoGTPef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdRhoGTPef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbcdRhoGTPef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcpERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcppERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcpERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcppERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcpERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcppERKdef
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbppMEKcdRhoGTPepRhoGAPf
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdRhoGTPepRhoGAPf
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdRhoGTPepRhoGAPf
Compartment: Cell
Initial concentration: 0.0
 
 EGF-pEGFR-2-Grb2-MEKK1aRafbcdRhoGTPepRhoGAPf
Compartment: Cell
Initial concentration: 0.0
 
R1 (2)
 
   k1
Value: 100.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.0038   (Units: sec_1)
Constant
 
R2 (2)
 
   k1
Value: 10.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.02   (Units: sec_1)
Constant
 
R3 (1)
 
   k1
Value: 2.014   (Units: sec_1)
Constant
 
R4 (2)
 
   k1
Value: 3.14   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.2   (Units: sec_1)
Constant
 
R5 (1)
 
   k1
Value: 0.2661   (Units: sec_1)
Constant
 
R6 (2)
 
   k1
Value: 90.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.6   (Units: sec_1)
Constant
 
R7 (1)
 
   k1
Value: 0.5838   (Units: sec_1)
Constant
 
R8 (2)
 
   k1
Value: 4.481   (Units: sec_1)
Constant
 
   k2
Value: 0.3   (Units: uM_1_s_1)
Constant
 
R9 (2)
 
   k1
Value: 3.114   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.2   (Units: sec_1)
Constant
 
R10 (1)
 
   k1
Value: 0.2661   (Units: sec_1)
Constant
 
R11 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.1   (Units: sec_1)
Constant
 
R12 (2)
 
   k1
Value: 10.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.0214   (Units: sec_1)
Constant
 
R13 (2)
 
   k1
Value: 0.1   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.0015   (Units: sec_1)
Constant
 
R14 (2)
 
   k1
Value: 10.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.045   (Units: sec_1)
Constant
 
R15 (2)
 
   k1
Value: 202.9   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.18   (Units: sec_1)
Constant
 
R16 (1)
 
   k1
Value: 0.1434   (Units: sec_1)
Constant
 
R17 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.05   (Units: sec_1)
Constant
 
R18 (2)
 
   k1
Value: 10.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.06   (Units: sec_1)
Constant
 
R19 (2)
 
   k1
Value: 2.734   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.025   (Units: sec_1)
Constant
 
R20 (2)
 
   k1
Value: 202.9   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.18   (Units: sec_1)
Constant
 
R21 (1)
 
   k1
Value: 0.1434   (Units: sec_1)
Constant
 
R22 (2)
 
   k1
Value: 1.754   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.05   (Units: sec_1)
Constant
 
R23 (1)
 
   k1
Value: 0.7624   (Units: sec_1)
Constant
 
R24 (2)
 
   k1
Value: 4.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.01833   (Units: sec_1)
Constant
 
R25 (1)
 
   k1
Value: 3.5   (Units: sec_1)
Constant
 
R26 (2)
 
   k1
Value: 4.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.01833   (Units: sec_1)
Constant
 
R27 (1)
 
   k1
Value: 2.9   (Units: sec_1)
Constant
 
R28 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.033   (Units: sec_1)
Constant
 
R29 (1)
 
   k1
Value: 16.0   (Units: sec_1)
Constant
 
R30 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.033   (Units: sec_1)
Constant
 
R31 (1)
 
   k1
Value: 5.7   (Units: sec_1)
Constant
 
R32 (2)
 
   k1
Value: 71.7   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.2   (Units: sec_1)
Constant
 
R33 (1)
 
   k1
Value: 1.0   (Units: sec_1)
Constant
 
R34 (2)
 
   k1
Value: 14.3   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.8   (Units: sec_1)
Constant
 
R35 (1)
 
   k1
Value: 0.058   (Units: sec_1)
Constant
 
R36 (2)
 
   k1
Value: 0.25   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R37 (1)
 
   k1
Value: 0.058   (Units: sec_1)
Constant
 
R38 (2)
 
   k1
Value: 7.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.6   (Units: sec_1)
Constant
 
R39 (1)
 
   k1
Value: 0.27   (Units: sec_1)
Constant
 
R40 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R41 (1)
 
   k1
Value: 0.3   (Units: sec_1)
Constant
 
R42 (1)
 
   k1
Value: 1.667E-5   (Units: sec_1)
Constant
 
R43 (2)
 
   k1
Value: 2.854   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.96   (Units: sec_1)
Constant
 
R44 (1)
 
   k1
Value: 7.6   (Units: sec_1)
Constant
 
R45 (2)
 
   k1
Value: 8.898   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.1   (Units: sec_1)
Constant
 
R46 (1)
 
   k1
Value: 0.426   (Units: sec_1)
Constant
 
R47 (2)
 
   k1
Value: 8.898   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.1   (Units: sec_1)
Constant
 
R48 (1)
 
   k1
Value: 0.426   (Units: sec_1)
Constant
 
R49 (1)
 
   k1
Value: 0.0020   (Units: sec_1)
Constant
 
R50 (2)
 
   k1
Value: 14.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.1743   (Units: sec_1)
Constant
 
R51 (1)
 
   k1
Value: 33.72   (Units: sec_1)
Constant
 
R52 (2)
 
   k1
Value: 1.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.038   (Units: sec_1)
Constant
 
R53 (1)
 
   k1
Value: 0.595   (Units: sec_1)
Constant
 
R54 (2)
 
   k1
Value: 25.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 3.5   (Units: sec_1)
Constant
 
R55 (1)
 
   k1
Value: 25.0   (Units: sec_1)
Constant
 
R56 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.0   (Units: sec_1)
Constant
 
R57 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.0   (Units: sec_1)
Constant
 
R58 (1)
 
   k1
Value: 3.0   (Units: sec_1)
Constant
 
R59 (2)
 
   k1
Value: 0.0010   (Units: sec_1)
Constant
 
   k2
Value: 10.0   (Units: uM_1_s_1)
Constant
 
R60 (2)
 
   k1
Value: 1.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.9   (Units: sec_1)
Constant
 
R61 (1)
 
   k1
Value: 0.0010   (Units: sec_1)
Constant
 
R62 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R63 (1)
 
   k1
Value: 3.0   (Units: sec_1)
Constant
 
R64 (1)
 
   k1
Value: 0.0010   (Units: sec_1)
Constant
 
R65 (2)
 
   k1
Value: 1.1   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.033   (Units: sec_1)
Constant
 
R66 (1)
 
   k1
Value: 16.0   (Units: sec_1)
Constant
 
R67 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R68 (1)
 
   k1
Value: 5.0   (Units: sec_1)
Constant
 
R69 (1)
 
   k1
Value: 0.1298   (Units: sec_1)
Constant
 
R70 (1)
 
   k1
Value: 17.0   (Units: sec_1)
Constant
 
R71 (2)
 
   k1
Value: 10.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.0214   (Units: sec_1)
Constant
 
R72 (2)
 
   k1
Value: 2.029   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.18   (Units: sec_1)
Constant
 
R73 (1)
 
   k1
Value: 0.1434   (Units: sec_1)
Constant
 
R74 (2)
 
   k1
Value: 2.845   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.96   (Units: sec_1)
Constant
 
R75 (1)
 
   k1
Value: 0.262   (Units: sec_1)
Constant
 
R76 (2)
 
   k1
Value: 2.845   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.96   (Units: sec_1)
Constant
 
R77 (1)
 
   k1
Value: 1.205   (Units: sec_1)
Constant
 
R78 (2)
 
   k1
Value: 20.29   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.18   (Units: sec_1)
Constant
 
R79 (2)
 
   k1
Value: 20.29   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.18   (Units: sec_1)
Constant
 
R80 (1)
 
   k1
Value: 4.98   (Units: sec_1)
Constant
 
R81 (1)
 
   k1
Value: 0.262   (Units: sec_1)
Constant
 
R82 (2)
 
   k1
Value: 0.1   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.01   (Units: sec_1)
Constant
 
R83 (2)
 
   k1
Value: 2.854   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.96   (Units: sec_1)
Constant
 
R84 (1)
 
   k1
Value: 7.76   (Units: sec_1)
Constant
 
R85 (2)
 
   k1
Value: 10.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.0   (Units: sec_1)
Constant
 
R86 (2)
 
   k1
Value: 10.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.0   (Units: sec_1)
Constant
 
R87 (1)
 
   k1
Value: 2.661   (Units: sec_1)
Constant
 
R88 (1)
 
   k1
Value: 2.661   (Units: sec_1)
Constant
 
R89 (2)
 
   k1
Value: 3.114   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.2   (Units: sec_1)
Constant
 
R90 (1)
 
   k1
Value: 2.661   (Units: sec_1)
Constant
 
R91 (2)
 
   k1
Value: 3.114   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.2   (Units: sec_1)
Constant
 
R92 (1)
 
   k1
Value: 2.661   (Units: sec_1)
Constant
 
R93 (2)
 
   k1
Value: 3.114   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.2   (Units: sec_1)
Constant
 
R94 (1)
 
   k1
Value: 2.661   (Units: sec_1)
Constant
 
R95 (2)
 
   k1
Value: 3.114   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.2   (Units: sec_1)
Constant
 
R96 (1)
 
   k1
Value: 2.661   (Units: sec_1)
Constant
 
R97 (2)
 
   k1
Value: 3.114   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.2   (Units: sec_1)
Constant
 
R98 (1)
 
   k1
Value: 2.661   (Units: sec_1)
Constant
 
R99 (2)
 
   k1
Value: 40.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.9356   (Units: sec_1)
Constant
 
R100 (1)
 
   k1
Value: 10.0   (Units: sec_1)
Constant
 
R101 (1)
 
   k1
Value: 0.1298   (Units: sec_1)
Constant
 
R102 (2)
 
   k1
Value: 40.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.9356   (Units: sec_1)
Constant
 
R103 (1)
 
   k1
Value: 10.0   (Units: sec_1)
Constant
 
R104 (2)
 
   k1
Value: 2.845   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.96   (Units: sec_1)
Constant
 
R105 (1)
 
   k1
Value: 1.205   (Units: sec_1)
Constant
 
R106 (2)
 
   k1
Value: 1.754   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R107 (1)
 
   k1
Value: 7.624   (Units: sec_1)
Constant
 
R108 (2)
 
   k1
Value: 40.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.9356   (Units: sec_1)
Constant
 
R109 (1)
 
   k1
Value: 40.0   (Units: sec_1)
Constant
 
R110 (2)
 
   k1
Value: 0.0010   (Units: sec_1)
Constant
 
   k2
Value: 3.302E-4   (Units: uM_1_s_1)
Constant
 
R111 (2)
 
   k1
Value: 1.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.0   (Units: sec_1)
Constant
 
R112 (1)
 
   k1
Value: 0.01   (Units: sec_1)
Constant
 
R113 (2)
 
   k1
Value: 0.1   (Units: sec_1)
Constant
 
   k2
Value: 1.2987   (Units: uM_1_s_1)
Constant
 
R114 (2)
 
   k1
Value: 0.5   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.0050   (Units: sec_1)
Constant
 
R115 (2)
 
   k1
Value: 0.5   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.0050   (Units: sec_1)
Constant
 
R116 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.01   (Units: sec_1)
Constant
 
R117 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.01   (Units: sec_1)
Constant
 
R118 (1)
 
   k1
Value: 0.0010   (Units: sec_1)
Constant
 
R119 (1)
 
   k1
Value: 0.0010   (Units: sec_1)
Constant
 
R120 (1)
 
   k1
Value: 0.0050   (Units: sec_1)
Constant
 
R121 (2)
 
   k1
Value: 1.1   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.033   (Units: sec_1)
Constant
 
R122 (1)
 
   k1
Value: 16.0   (Units: sec_1)
Constant
 
R123 (2)
 
   k1
Value: 10.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.0050   (Units: sec_1)
Constant
 
R124 (1)
 
   k1
Value: 129.8   (Units: sec_1)
Constant
 
R125 (2)
 
   k1
Value: 1.754   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.05   (Units: sec_1)
Constant
 
R126 (1)
 
   k1
Value: 0.07624   (Units: sec_1)
Constant
 
R127 (2)
 
   k1
Value: 8.898   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.0   (Units: sec_1)
Constant
 
R128 (1)
 
   k1
Value: 0.426   (Units: sec_1)
Constant
 
R129 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.05   (Units: sec_1)
Constant
 
R130 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.1   (Units: sec_1)
Constant
 
R131 (2)
 
   k1
Value: 3.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R132 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.67   (Units: sec_1)
Constant
 
R133 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R134 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R135 (2)
 
   k1
Value: 1.67   (Units: sec_1)
Constant
 
   k2
Value: 5.0   (Units: uM_1_s_1)
Constant
 
R136 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.67   (Units: sec_1)
Constant
 
R137 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R138 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R139 (2)
 
   k1
Value: 1.67   (Units: sec_1)
Constant
 
   k2
Value: 5.0   (Units: uM_1_s_1)
Constant
 
R140 (2)
 
   k1
Value: 1.667   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R141 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.67   (Units: sec_1)
Constant
 
R142 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R143 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R144 (2)
 
   k1
Value: 1.67   (Units: sec_1)
Constant
 
   k2
Value: 5.0   (Units: uM_1_s_1)
Constant
 
R145 (2)
 
   k1
Value: 1.667   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R146 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.67   (Units: sec_1)
Constant
 
R147 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R148 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R149 (2)
 
   k1
Value: 1.67   (Units: sec_1)
Constant
 
   k2
Value: 5.0   (Units: uM_1_s_1)
Constant
 
R150 (2)
 
   k1
Value: 1.667   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R151 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.67   (Units: sec_1)
Constant
 
R152 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R153 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R154 (2)
 
   k1
Value: 1.67   (Units: sec_1)
Constant
 
   k2
Value: 5.0   (Units: uM_1_s_1)
Constant
 
R155 (2)
 
   k1
Value: 1.667   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R156 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.67   (Units: sec_1)
Constant
 
R157 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R158 (1)
 
   k1
Value: 1.693   (Units: sec_1)
Constant
 
R159 (2)
 
   k1
Value: 1.67   (Units: sec_1)
Constant
 
   k2
Value: 5.0   (Units: uM_1_s_1)
Constant
 
R160 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.67   (Units: sec_1)
Constant
 
R161 (1)
 
   k1
Value: 0.1002   (Units: sec_1)
Constant
 
R162 (1)
 
   k1
Value: 0.1002   (Units: sec_1)
Constant
 
R163 (1)
 
   k1
Value: 1.67   (Units: sec_1)
Constant
 
R164 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant
 
   k2
Value: 1.67   (Units: sec_1)
Constant
 
R165 (1)
 
   k1
Value: 0.1002   (Units: sec_1)
Constant
 
R166 (1)
 
   k1
Value: 0.1002   (Units: sec_1)
Constant
 
R167 (1)
 
   k1
Value: 1.67   (Units: sec_1)
Constant
 
R168 (2)
 
   k1
Value: 1.667   (Units: uM_1_s_1)
Constant
 
   k2
Value: 0.5   (Units: sec_1)
Constant
 
R169 (2)
 
   k1
Value: 5.0   (Units: uM_1_s_1)
Constant