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BIOMD0000000194 - Ibrahim2008_Cdc20_Sequestring_Template_Model

 

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Reference Publication
Publication ID: 18295960
Ibrahim B, Dittrich P, Diekmann S, Schmitt E.
Mad2 binding is not sufficient for complete Cdc20 sequestering in mitotic transition control (an in silico study).
Biophys. Chem. 2008 Apr; 134(1-2): 93-100
Bio Systems Analysis Group, Institute of Computer Science, Friedrich-Schiller-University Jena, Ernst-Abbe-Platz 1-4, D-07743 Jena, Germany.  [more]
Model
Original Model: BIOMD0000000194.xml.origin
Submitter: Bashar Ibrahim
Submission ID: MODEL1667525941
Submission Date: 19 Sep 2008 16:32:34 UTC
Last Modification Date: 23 Sep 2009 17:09:50 UTC
Creation Date: 11 Sep 2008 20:58:11 UTC
Encoders:  Lukas Endler
   Eberhard Schmitt
   Peter Dittrich
   Stephan Diekmann
   Bashar Ibrahim
set #1
bqbiol:isPartOf KEGG Pathway hsa04110
bqbiol:isVersionOf Reactome REACT_2137.2
Gene Ontology mitotic spindle assembly checkpoint
bqbiol:occursIn Taxonomy Homo sapiens
Notes
Biophysical Chemistry 134 (2008) 93-100

Mad2 binding is not sufficient for complete Cdc20 sequestering in mitotic transition control (an in silico study)


Bashar Ibrahim, Peter Dittrich, Stephan Diekmann, Eberhard Schmitt

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.
For more information see the terms of use .
To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

Model
Publication ID: 18295960 Submission Date: 19 Sep 2008 16:32:34 UTC Last Modification Date: 23 Sep 2009 17:09:50 UTC Creation Date: 11 Sep 2008 20:58:11 UTC
Mathematical expressions
Reactions
R6 R7 R8  
Events
Microtubule attachment      
Physical entities
Compartments Species
Cytoplasm Mad1:C-Mad2 O-Mad2 Mad1:C-Mad2:O-Mad2*
Cdc20 Cdc20:C-Mad2  
Global parameters
eta_T gamma_T alpha_T beta_T
u const_val_0 const_val_1  
Reactions (3)
 
 R6 [Mad1:C-Mad2] + [O-Mad2] ↔ [Mad1:C-Mad2:O-Mad2*];  
 
 R7 [Mad1:C-Mad2:O-Mad2*] + [Cdc20] → [Mad1:C-Mad2] + [Cdc20:C-Mad2];  
 
 R8 [Cdc20:C-Mad2] → [Cdc20] + [O-Mad2];  
 
Events (1)
 
 Microtubule attachment
u = const_val_0
 
 Cytoplasm Spatial dimensions: 3.0  Compartment size: 1.0
 
 Mad1:C-Mad2
Compartment: Cytoplasm
Initial concentration: 5.0E-8  (Units: mole)
 
 O-Mad2
Compartment: Cytoplasm
Initial concentration: 1.5E-7  (Units: mole)
 
 Mad1:C-Mad2:O-Mad2*
Compartment: Cytoplasm
Initial concentration: 0.0  (Units: mole)
 
 Cdc20
Compartment: Cytoplasm
Initial concentration: 2.2E-7  (Units: mole)
 
 Cdc20:C-Mad2
Compartment: Cytoplasm
Initial concentration: 0.0  (Units: mole)
 
Global Parameters (7)
 
 eta_T
Value: 0.01   (Units: per second)
Constant
 
 gamma_T
Value: 1.0E9   (Units:  liter per mole per second)
Constant
 
 alpha_T
Value: 200000.0   (Units:  liter per mole per second)
Constant
 
 beta_T
Value: 0.2   (Units: per second)
Constant
 
 u
Value: 1.0   (Units: dimensionless)
 
   const_val_0
Constant
 
   const_val_1
Value: 1.0   (Units: dimensionless)
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000194

Curator's comment: (updated: 19 Sep 2008 17:31:58 BST)

Reproduction of fig 2b using SBML ODE Solver for integration and Xmgrace for plotting

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