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BIOMD0000000155 - Zatorsky2006_p53_Model6

 

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Reference Publication
Publication ID: 16773083
Geva-Zatorsky N, Rosenfeld N, Itzkovitz S, Milo R, Sigal A, Dekel E, Yarnitzky T, Liron Y, Polak P, Lahav G, Alon U.
Oscillations and variability in the p53 system.
Mol. Syst. Biol. 2006; 2: 2006.0033
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.  [more]
Model
Original Model: BIOMD0000000155.xml.origin
Submitter: Harish Dharuri
Submission ID: MODEL0076407823
Submission Date: 14 Jan 2008 21:30:52 UTC
Last Modification Date: 20 Mar 2014 16:25:14 UTC
Creation Date: 10 Jan 2008 17:38:04 UTC
Encoders:  Harish Dharuri
   Vijayalakshmi Chelliah
set #1
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
set #2
bqmodel:isDerivedFrom BioModels Database Zatorsky2006_p53_Model1
BioModels Database Zatorsky2006_p53_Model3
BioModels Database Zatorsky2006_p53_Model5
BioModels Database Zatorsky2006_p53_Model4
BioModels Database Zatorsky2006_p53_Model2
set #3
bqbiol:isPartOf KEGG Pathway hsa04115
Gene Ontology DNA damage response, signal transduction by p53 class mediator
bqbiol:hasTaxon Taxonomy Homo sapiens
set #4
bqbiol:occursIn Brenda Tissue Ontology BTO:0000093
Notes

The model reproduces Fig 6B of the paper for model 6. The model was reproduced using XPP.


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 16773083 Submission Date: 14 Jan 2008 21:30:52 UTC Last Modification Date: 20 Mar 2014 16:25:14 UTC Creation Date: 10 Jan 2008 17:38:04 UTC
Mathematical expressions
Reactions
p53 production Mdm2 dependent p53 degradation p53 dependent Mdm2 production Mdm2 degradation
Rules
Rate Rule (variable: S)      
Physical entities
Compartments Species
cell p53 Mdm2  
Global parameters
beta_x psi alpha_xy beta_y
alpha_y tau S beta_S
alpha_S n    
Reactions (4)
 
 p53 production  → [p53];  
 
 Mdm2 dependent p53 degradation [p53] → ;   {Mdm2}
 
 p53 dependent Mdm2 production  → [Mdm2];   {p53}
 
 Mdm2 degradation [Mdm2] → ;  
 
Rules (1)
 
 Rate Rule (name: S) d [ S] / d t= beta_S-alpha_S*y*S
 
 cell Spatial dimensions: 3.0  Compartment size: 1.0
 
 p53
Compartment: cell
Initial concentration: 0.0
 
 Mdm2
Compartment: cell
Initial concentration: 0.9
 
Global Parameters (10)
 
   beta_x
Value: 0.9
Constant
 
   psi
Value: 1.0
Constant
 
   alpha_xy
Value: 1.4
Constant
 
   beta_y
Value: 1.0
Constant
 
   alpha_y
Value: 0.7
Constant
 
   tau
Value: 0.9
Constant
 
   S  
 
   beta_S
Value: 0.9
Constant
 
   alpha_S
Value: 2.7
Constant
 
   n
Value: 4.0
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000155

Curator's comment: (updated: 11 Jan 2008 22:27:53 GMT)

Plot corresponds to Fig 6B for model 6. Simulation result obtained using xpp.

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